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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
Mefloquine inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] |
CTD |
PMID:16004972 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
increases export multiple interactions |
ISO |
ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein daidzein inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Quercetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; resveratrol inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Silymarin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] |
CTD |
PMID:16156793 |
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NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
affects transport multiple interactions increases export increases transport |
EXP ISO |
ABCC2 protein affects the transport of 5(6)-carboxy-2',7'-dichlorofluorescein 4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]]; Ascorbic Acid promotes the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Benzbromarone inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Calcium deficiency inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; cyanoginosin LR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin RR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin-LF inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Probenecid inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Tobacco Smoke Pollution inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog] ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog [ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 gene mutant form inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein] |
CTD |
PMID:19326901 PMID:21240898 PMID:21341280 PMID:23562342 PMID:24907646 PMID:24909372 PMID:24973091 PMID:25862123 PMID:27450509 PMID:31348918 More...
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions increases transport |
EXP ISO |
[ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein Benzbromarone inhibits the reaction [ABCC3 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein] |
CTD |
PMID:24907646 PMID:31348918 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
multiple interactions increases uptake increases transport |
ISO |
Benzbromarone inhibits the reaction [ABCC5 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein] ABCC5 protein results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein |
CTD |
PMID:31348918 PMID:35066093 |
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NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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G |
Slc22a8 |
solute carrier family 22 member 8 |
multiple interactions increases transport |
ISO |
quercetin 3'-sulfate inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein] |
CTD |
PMID:21244849 |
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NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione] |
CTD |
PMID:16049127 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
increases export |
ISO |
ABCC1 protein results in increased export of 6-carboxyfluorescein |
CTD |
PMID:17940500 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
affects export multiple interactions |
ISO |
ABCC2 protein affects the export of 6-carboxyfluorescein Probenecid inhibits the reaction [ABCC2 protein affects the export of 6-carboxyfluorescein] |
CTD |
PMID:11477083 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Slc22a6 |
solute carrier family 22 member 6 |
multiple interactions increases import |
ISO |
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein] |
CTD |
PMID:28629854 |
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NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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G |
Slc22a8 |
solute carrier family 22 member 8 |
increases import multiple interactions |
ISO |
SLC22A8 protein results in increased import of 6-carboxyfluorescein 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Cadmium Chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; lead chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; sodium arsenate promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein] |
CTD |
PMID:28629854 |
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NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases export multiple interactions increases secretion |
ISO |
ABCB1 protein results in increased export of fluorexon Amiodarone inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Clotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Reserpine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon] [carvedilol results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; [Verapamil results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; Beclomethasone inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; desisobutyrylciclesonide inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of fluorexon] |
CTD |
PMID:10571255 PMID:12235267 PMID:16442095 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
affects export increases export increases import affects transport multiple interactions |
ISO |
ABCC1 protein affects the export of fluorexon ABCC1 protein results in increased export of fluorexon ABCC1 protein results in increased import of fluorexon ABCC1 protein affects the transport of fluorexon Mefloquine inhibits the reaction [ABCC1 protein affects the export of fluorexon]; nobiletin promotes the reaction [ABCC1 protein results in increased import of fluorexon]; Quercetin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; robinetin inhibits the reaction [ABCC1 protein affects the export of fluorexon]; Silymarin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein affects the export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; Vincristine inhibits the reaction [ABCC1 protein affects the transport of fluorexon] |
CTD |
PMID:10685512 PMID:15670588 PMID:16004972 PMID:16156793 PMID:18955043 PMID:26454883 More...
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
affects export affects transport multiple interactions increases abundance |
ISO |
ABCC2 protein affects the export of fluorexon ABCC2 protein affects the transport of fluorexon robinetin inhibits the reaction [ABCC2 protein affects the export of fluorexon] ABCC2 protein alternative form results in increased abundance of fluorexon |
CTD |
PMID:15670588 PMID:15848949 PMID:22027652 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc6 |
ATP binding cassette subfamily C member 6 |
affects transport |
ISO |
ABCC6 affects the transport of fluorexon |
CTD |
PMID:14667841 |
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NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
affects export multiple interactions |
ISO |
ABCB11 protein affects the export of calcein AM ditekiren inhibits the reaction [ABCB11 protein affects the export of calcein AM] |
CTD |
PMID:10617675 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
affects export increases export multiple interactions increases activity increases transport increases secretion |
ISO EXP |
ABCB1 protein affects the export of calcein AM ABCB1 protein results in increased export of calcein AM ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM] 2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Endosulfan co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [phosalone co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Verapamil binds to and results in decreased activity of ABCB1 protein] inhibits the reaction [sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]]; ABCB1 protein affects the reaction [Mifepristone results in decreased transport of calcein AM]; ABCB1 protein affects the reaction [zosuquidar trihydrochloride results in decreased transport of calcein AM]; Atorvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; chlorpyrifos-methyl affects the reaction [ABCB1 protein results in increased transport of calcein AM]; Cyclosporine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; deoxynivalenol inhibits the reaction [valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]]; Diazinon inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Diazinon promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Endosulfan inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; fenoxycarb inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; fenvalerate inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; phosalone inhibits the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; propiconazole inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Reserpine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Simvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Verapamil promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]] calcein AM results in increased activity of ABCB1 protein mutant form |
CTD |
PMID:10617675 PMID:12711602 PMID:15616150 PMID:16121039 PMID:19223659 PMID:19549930 PMID:21321059 PMID:21783720 PMID:29174985 PMID:30217652 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
increases transport multiple interactions |
ISO |
ABCC1 protein results in increased transport of calcein AM [ABCC1 protein results in increased susceptibility to Silver Nitrate] which results in decreased export of calcein AM; [ABCC1 protein results in increased susceptibility to Silver] which results in decreased export of calcein AM; [MLN 8237 results in decreased activity of ABCC1 protein] which results in decreased export of calcein AM; [MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; [verlukast results in decreased activity of ABCC1 protein] which results in decreased export of calcein AM; verlukast inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; zearalenol metabolite inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC1 protein results in increased transport of calcein AM] |
CTD |
PMID:19239227 PMID:19647055 PMID:27376922 PMID:34896433 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
affects transport multiple interactions increases transport increases export |
ISO EXP |
ABCC2 protein affects the transport of calcein AM Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM] [MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM; Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; montelukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC2 protein results in increased transport of calcein AM] |
CTD |
PMID:15210835 PMID:15616150 PMID:19239227 PMID:19647055 PMID:19952419 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
affects transport multiple interactions increases transport |
ISO |
ABCC3 protein affects the transport of calcein AM Dexamethasone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Glutathione promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Hydrocortisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Prednisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; verlukast inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC3 protein results in increased transport of calcein AM] |
CTD |
PMID:15210835 PMID:15979871 PMID:19647055 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
Glutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM] |
CTD |
PMID:15210835 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcc6 |
ATP binding cassette subfamily C member 6 |
multiple interactions |
ISO |
Glutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM] |
CTD |
PMID:15210835 |
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NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
[MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; [MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM |
CTD |
PMID:19239227 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
affects export |
ISO |
ABCC1 protein affects the export of Fluo-3 |
CTD |
PMID:15948026 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions increases secretion |
EXP |
Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased secretion of Fluo-3]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased secretion of Fluo-3] |
CTD |
PMID:9794919 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
multiple interactions |
ISO |
[CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein; Tranylcypromine inhibits the reaction [[CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein] |
CTD |
PMID:23850985 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Fluorescein results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Slc22a6 |
solute carrier family 22 member 6 |
multiple interactions |
ISO |
Fluorescein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] |
CTD |
PMID:11602689 |
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NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
increases uptake multiple interactions |
ISO |
SLCO1B3 protein results in increased uptake of Fluorescein bisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; bisphenol F promotes the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; Probenecid inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; tetrabromobisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein] |
CTD |
PMID:27989701 |
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NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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G |
Slco3a1 |
solute carrier organic anion transporter family, member 3a1 |
increases uptake multiple interactions |
ISO |
SLCO3A1 protein results in increased uptake of Fluorescein Cyclosporine promotes the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]; simvastatin acid affects the reaction [SLCO3A1 protein results in increased uptake of Fluorescein] |
CTD |
PMID:28887287 |
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NCBI chr 1:128,115,184...128,387,887
Ensembl chr 1:128,106,228...128,387,925
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G |
Abcb7 |
ATP binding cassette subfamily B member 7 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to ABCB7 protein |
CTD |
PMID:27129696 |
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NCBI chr X:69,295,598...69,436,775
Ensembl chr X:69,295,552...69,436,858
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G |
Akr1c2 |
aldo-keto reductase family 1, member C2 |
increases expression |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of AKR1C2 mRNA |
CTD |
PMID:20491607 |
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NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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G |
Anxa4 |
annexin A4 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to ANXA4 protein |
CTD |
PMID:27129696 |
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NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
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G |
Arhgap6 |
Rho GTPase activating protein 6 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to ARHGAP6 protein |
CTD |
PMID:27129696 |
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NCBI chr X:24,953,464...25,490,003
Ensembl chr X:24,953,464...25,488,663
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G |
Azi2 |
5-azacytidine induced 2 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to AZI2 protein |
CTD |
PMID:27129696 |
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NCBI chr 8:117,773,248...117,797,844
Ensembl chr 8:117,773,279...117,797,847
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G |
Capzb |
capping actin protein of muscle Z-line subunit beta |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to CAPZB protein |
CTD |
PMID:27129696 |
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NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409
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G |
Cd109 |
CD109 molecule |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to CD109 protein |
CTD |
PMID:27129696 |
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NCBI chr 8:79,454,480...79,569,195
Ensembl chr 8:79,454,480...79,569,194
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G |
Cd180 |
CD180 molecule |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to CD180 protein |
CTD |
PMID:27129696 |
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NCBI chr 2:33,855,940...33,870,046
Ensembl chr 2:33,855,991...33,899,936
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G |
Cd86 |
CD86 molecule |
increases expression |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of CD86 protein |
CTD |
PMID:19665512 |
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NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Cd93 |
CD93 molecule |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to CD93 protein |
CTD |
PMID:27129696 |
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NCBI chr 3:135,891,859...135,898,378
Ensembl chr 3:135,891,859...135,898,378
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G |
Cdc20 |
cell division cycle 20 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to CDC20 protein |
CTD |
PMID:27129696 |
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NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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G |
Copa |
COPI coat complex subunit alpha |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to COPA protein |
CTD |
PMID:27129696 |
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NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of CYP1A1 mRNA |
CTD |
PMID:20491607 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Dcaf4 |
DDB1 and CUL4 associated factor 4 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to DCAF4 protein |
CTD |
PMID:27129696 |
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NCBI chr 6:103,154,847...103,180,992
Ensembl chr 6:103,154,867...103,180,982
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G |
Dot1l |
DOT1 like histone lysine methyltransferase |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to DOT1L protein |
CTD |
PMID:27129696 |
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NCBI chr 7:8,917,786...8,959,474
Ensembl chr 7:8,917,786...8,956,475
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G |
Elac1 |
elaC ribonuclease Z 1 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to ELAC1 protein |
CTD |
PMID:27129696 |
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NCBI chr18:67,321,231...67,341,358
Ensembl chr18:67,323,583...67,340,936
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G |
Enpp7 |
ectonucleotide pyrophosphatase/phosphodiesterase 7 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to ENPP7 protein |
CTD |
PMID:27129696 |
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NCBI chr10:104,242,223...104,246,589
Ensembl chr10:104,242,223...104,246,589
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G |
Flrt3 |
fibronectin leucine rich transmembrane protein 3 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to FLRT3 protein |
CTD |
PMID:27129696 |
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NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841
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G |
Fn1 |
fibronectin 1 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to FN1 protein |
CTD |
PMID:27129696 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of HMOX1 protein [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein |
CTD |
PMID:27871981 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to HSPA5 protein |
CTD |
PMID:27129696 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to HSPA9 protein |
CTD |
PMID:27129696 |
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NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein |
CTD |
PMID:29198882 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to IKBKB protein |
CTD |
PMID:27129696 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Ikzf4 |
IKAROS family zinc finger 4 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to IKZF4 protein |
CTD |
PMID:27129696 |
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NCBI chr 7:1,063,283...1,102,940
Ensembl chr 7:1,056,890...1,084,341
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G |
Il17re |
interleukin 17 receptor E |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to IL17RE protein |
CTD |
PMID:27129696 |
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NCBI chr 4:146,604,547...146,618,206
Ensembl chr 4:146,605,526...146,618,206
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G |
Il31ra |
interleukin 31 receptor A |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to IL31RA protein |
CTD |
PMID:27129696 |
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NCBI chr 2:44,118,748...44,189,943
Ensembl chr 2:44,122,624...44,183,767
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G |
Il4 |
interleukin 4 |
multiple interactions increases expression |
ISO |
[Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; [dibutyrylglycerol analog co-treated with Fluorescein-5-isothiocyanate] affects the secretion of IL4 protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]] |
CTD |
PMID:27871981 PMID:29198882 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Lypd3 |
Ly6/Plaur domain containing 3 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to LYPD3 protein |
CTD |
PMID:27129696 |
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NCBI chr 1:80,226,449...80,230,901
Ensembl chr 1:80,226,449...80,230,901
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G |
Maff |
MAF bZIP transcription factor F |
increases expression |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of MAFF mRNA |
CTD |
PMID:20491607 |
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NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
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G |
Map3k20 |
mitogen-activated protein kinase kinase kinase 20 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to MAP3K20 protein |
CTD |
PMID:27129696 |
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NCBI chr 3:57,128,561...57,289,943
Ensembl chr 3:57,130,551...57,289,626
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO |
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK1 protein Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK1 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:27129696 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK3 protein Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK3 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:27129696 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation |
ISO |
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK8 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:27129696 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions increases phosphorylation |
ISO |
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK9 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:27129696 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mt2A |
metallothionein 2A |
increases expression |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of MT2A mRNA |
CTD |
PMID:20491607 |
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NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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G |
Mybpc1 |
myosin binding protein C1 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to MYBPC1 protein |
CTD |
PMID:27129696 |
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NCBI chr 7:22,930,350...23,015,981
Ensembl chr 7:22,930,350...23,015,957
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein |
CTD |
PMID:27871981 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of NQO1 mRNA Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]] |
CTD |
PMID:20491607 PMID:27871981 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Plce1 |
phospholipase C, epsilon 1 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to PLCE1 protein |
CTD |
PMID:27129696 |
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NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438
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G |
Postn |
periostin |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to POSTN protein |
CTD |
PMID:27129696 |
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NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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G |
Pprc1 |
PPARG related coactivator 1 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to PPRC1 protein |
CTD |
PMID:27129696 |
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NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587
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G |
Prkcb |
protein kinase C, beta |
increases expression |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of PRKCB protein |
CTD |
PMID:31958493 |
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NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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G |
Psd4 |
pleckstrin and Sec7 domain containing 4 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to PSD4 protein |
CTD |
PMID:27129696 |
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NCBI chr 3:7,137,069...7,173,571
Ensembl chr 3:7,137,155...7,173,571
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G |
Psmd14 |
proteasome 26S subunit, non-ATPase 14 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to PSMD14 protein |
CTD |
PMID:27129696 |
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NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein; Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein] |
CTD |
PMID:27871981 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Scn5a |
sodium voltage-gated channel alpha subunit 5 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to SCN5A protein |
CTD |
PMID:27129696 |
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NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
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G |
Skor1 |
SKI family transcriptional corepressor 1 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to SKOR1 protein |
CTD |
PMID:27129696 |
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NCBI chr 8:63,599,153...63,609,727
Ensembl chr 8:63,599,165...63,607,756
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G |
Slc38a10 |
solute carrier family 38, member 10 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to SLC38A10 protein |
CTD |
PMID:27129696 |
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NCBI chr10:105,386,836...105,436,636
Ensembl chr10:105,386,836...105,436,636
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions increases phosphorylation |
ISO |
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]] |
CTD |
PMID:27871981 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Stat5a |
signal transducer and activator of transcription 5A |
multiple interactions increases phosphorylation |
ISO |
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]] |
CTD |
PMID:27871981 |
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NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
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G |
Stat6 |
signal transducer and activator of transcription 6 |
increases phosphorylation multiple interactions |
ISO |
Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]] |
CTD |
PMID:27871981 |
|
NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
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G |
Trpa1 |
transient receptor potential cation channel, subfamily A, member 1 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to TRPA1 protein |
CTD |
PMID:27129696 |
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NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
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G |
Tslp |
thymic stromal lymphopoietin |
increases expression multiple interactions |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of TSLP protein diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]] |
CTD |
PMID:27871981 |
|
NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
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G |
Txn1 |
thioredoxin 1 |
increases expression |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of TXN mRNA |
CTD |
PMID:20491607 |
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NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Usp3 |
ubiquitin specific peptidase 3 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to USP3 protein |
CTD |
PMID:27129696 |
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NCBI chr 8:67,078,249...67,154,109
Ensembl chr 8:67,079,927...67,154,111
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
EXP |
gallein inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein] |
CTD |
PMID:27160165 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Tslp |
thymic stromal lymphopoietin |
multiple interactions |
ISO |
Phloxine O inhibits the reaction [calcipotriol increases expression of Tslp mRNA and protein in skin of external ear and phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytes] |
RGD |
PMID:29310423 |
RGD:38549374 |
NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions decreases uptake increases export |
ISO EXP |
3-methylquercetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 3-methylquercetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; 5,7-dimethoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5,7-dimethoxyflavone inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; 5-hydroxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5-methoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5-oxo-hexahydroquinoline analog inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; [zosuquidar trihydrochloride results in decreased activity of ABCB1 protein] which results in decreased export of Rhodamine 123; abemaciclib inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; baicalein inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; baicalein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; betulin inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; biochanin A inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; biochanin A promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; CEP 33779 inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; daidzein inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; flavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; formononetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Genistein promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; glycitein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; isovitexin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; kaempferol inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; myricetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; naringenin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; naringin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Quercetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; Quercetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; quercitrin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Rutin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; tangeretin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; tangeretin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; taxifolin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123] [P-glycoprotein inducer and activator TX5 results in increased activity of ABCB1 protein] which results in increased export of Rhodamine 123; [Verapamil results in decreased activity of ABCB1 protein] inhibits the reaction [P-glycoprotein inducer and activator TX5 results in increased export of Rhodamine 123] |
CTD |
PMID:25058526 PMID:27816545 PMID:30391378 PMID:31756430 PMID:33321149 PMID:34217736 PMID:34896433 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions increases export |
ISO |
abemaciclib inhibits the reaction [ABCG2 protein results in increased export of Rhodamine 123] |
CTD |
PMID:27816545 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Ache |
acetylcholinesterase |
decreases activity |
ISO |
rhodamine 6G results in decreased activity of ACHE protein |
CTD |
PMID:33844597 |
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NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases activity |
ISO |
Rose Bengal results in decreased activity of ABCB1 protein |
CTD |
PMID:20041016 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
decreases activity |
EXP |
Rose Bengal results in decreased activity of CYP19A1 protein |
CTD |
PMID:18310892 |
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NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
Rose Bengal results in decreased activity of CYP3A4 protein |
CTD |
PMID:20041016 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Gsta3 |
glutathione S-transferase alpha 3 |
decreases response to substance |
EXP |
GSTA3 protein results in decreased susceptibility to Rose Bengal |
CTD |
PMID:1740415 |
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NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
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G |
Iyd |
iodotyrosine deiodinase |
decreases activity |
ISO |
Rose Bengal results in decreased activity of IYD protein |
CTD |
PMID:24012475 |
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NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Rose Bengal results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Klkb1 |
kallikrein B1 |
multiple interactions decreases response to substance |
ISO |
7-Ala-angiotensin (1-7) inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; nimesulide inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; splitomicin inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal] |
CTD |
PMID:25339356 |
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NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
decreases activity |
ISO |
Rose Bengal results in decreased activity of UGT1A6 protein |
CTD |
PMID:20041016 |
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NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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