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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:27-hydroxy steroid
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Accession:CHEBI:37914 term browser browse the term
Synonyms:related_synonym: 27-hydroxy steroids


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withaferin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP withaferin A inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]] CTD PMID:20438634 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 multiple interactions EXP withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of ADAM17 protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 2:9,488,486...9,555,830
Ensembl chr 2:9,488,486...9,556,732
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein] CTD PMID:21266191 NCBI chr22:39,514,494...39,522,686
Ensembl chr22:39,519,672...39,522,683
Ensembl chr22:39,519,672...39,522,683
Ensembl chr22:39,519,672...39,522,683
JBrowse link
G BAD BCL2 associated agonist of cell death multiple interactions EXP withaferin A results in decreased expression of and results in decreased phosphorylation of BAD protein CTD PMID:20438634 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP withaferin A results in decreased expression of BCL2 protein CTD PMID:20438634 PMID:21256832 PMID:21964475 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2A1 BCL2 related protein A1 multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] CTD PMID:20438634 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196
JBrowse link
G BCL2L11 BCL2 like 11 decreases expression EXP withaferin A results in decreased expression of BCL2L11 protein CTD PMID:20438634 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,445
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] CTD PMID:20438634 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCND1 cyclin D1 multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] CTD PMID:20438634 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
affects binding
EXP withaferin A results in increased expression of and affects the localization of CDKN1A protein
withaferin A results in increased expression of CDKN1A mRNA
withaferin A binds to CDKN1A protein
CTD PMID:22973447 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDKN2AIP CDKN2A interacting protein decreases expression EXP withaferin A results in decreased expression of CDKN2AIP protein CTD PMID:22973447 NCBI chr 4:183,444,636...183,449,064
Ensembl chr 4:183,444,635...183,449,064
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL8 mRNA] CTD PMID:20438634 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G DDIT3 DNA damage inducible transcript 3 affects response to substance
multiple interactions
increases expression
EXP DDIT3 mRNA affects the susceptibility to withaferin A
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein]
CTD PMID:21266191 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DDIT4 DNA damage inducible transcript 4 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein] CTD PMID:21266191 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,924...72,276,036
Ensembl chr10:72,273,924...72,276,036
JBrowse link
G DNMT1 DNA methyltransferase 1 decreases expression EXP withaferin A results in decreased expression of DNMT1 mRNA; withaferin A results in decreased expression of DNMT1 protein CTD PMID:23593078 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,345...10,231,286
Ensembl chr19:10,133,345...10,231,286
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha decreases expression EXP withaferin A results in decreased expression of DNMT3A mRNA CTD PMID:23593078 NCBI chr 2:25,227,874...25,342,590
Ensembl chr 2:25,227,855...25,342,590
JBrowse link
G DNMT3B DNA methyltransferase 3 beta decreases expression EXP withaferin A results in decreased expression of DNMT3B mRNA CTD PMID:23593078 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,356
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation EXP withaferin A results in increased phosphorylation of EIF2A protein CTD PMID:21266191 NCBI chr 3:150,546,726...150,586,016
Ensembl chr 3:150,546,678...150,586,016
JBrowse link
G EZR ezrin multiple interactions EXP [withanone co-treated with withaferin A] results in decreased expression of EZR protein CTD PMID:25236891 NCBI chr 6:158,765,744...158,819,368
Ensembl chr 6:158,765,741...158,819,368
JBrowse link
G HDAC1 histone deacetylase 1 decreases expression EXP withaferin A results in decreased expression of HDAC1 protein CTD PMID:23593078 NCBI chr 1:32,292,083...32,333,628
Ensembl chr 1:32,292,083...32,333,635
JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K multiple interactions EXP [withanone co-treated with withaferin A] results in decreased expression of HNRNPK protein; withaferin A binds to and results in decreased activity of HNRNPK protein CTD PMID:25236891 NCBI chr 9:83,968,083...83,980,630
Ensembl chr 9:83,968,083...83,980,616
JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 affects binding
multiple interactions
EXP withaferin A binds to HSPA9 protein
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; [withanone co-treated with withaferin A] results in decreased expression of HSPA9 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]
CTD PMID:22973447 PMID:25236891 NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,416
Ensembl chr 5:138,553,756...138,575,416
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein] CTD PMID:20438634 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK1 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] CTD PMID:24019090 PMID:24632454 PMID:25236891 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK3 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] CTD PMID:24019090 PMID:24632454 PMID:25236891 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP withaferin A results in increased phosphorylation of MAPK8 protein CTD PMID:21964475 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases expression
EXP MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein]
withaferin A results in increased expression of MCL1 protein
CTD PMID:24019090 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,574,551...150,579,738
Ensembl chr 1:150,574,551...150,579,738
JBrowse link
G MECP2 methyl-CpG binding protein 2 decreases expression EXP withaferin A results in decreased expression of MECP2 protein CTD PMID:23593078 NCBI chr  X:154,021,573...154,097,717
Ensembl chr  X:154,021,573...154,137,103
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions EXP [withanone co-treated with withaferin A] results in decreased expression of MMP2 protein CTD PMID:25236891 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 affects binding EXP withaferin A binds to NFE2L2 protein CTD PMID:22973447 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] CTD PMID:20438634 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein] CTD PMID:20438634 PMID:24019090 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PROCR protein C receptor multiple interactions EXP withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr20:35,172,072...35,215,989
Ensembl chr20:35,172,072...35,216,240
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO withaferin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21396905 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] CTD PMID:20438634 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein] CTD PMID:24019090 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions ISO withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of and results in increased activity of STAT1 protein] CTD PMID:21396905 NCBI chr 2:190,968,989...191,014,197
Ensembl chr 2:190,908,460...191,020,960
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT3 protein] CTD PMID:21396905 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases activity
EXP
ISO
withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]
withaferin A results in decreased activity of TNF protein
CTD PMID:20438634 PMID:24632454 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] CTD PMID:20438634 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
affects binding
EXP withaferin A results in increased expression of TP53 mRNA
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]
withaferin A binds to TP53 protein
CTD PMID:22973447 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TUBA1A tubulin alpha 1a decreases expression EXP withaferin A results in decreased expression of TUBA1A mRNA CTD PMID:24297176 NCBI chr12:49,184,795...49,189,080
Ensembl chr12:49,184,795...49,189,080
Ensembl chr12:49,184,795...49,189,080
JBrowse link
G TUBB tubulin beta class I decreases expression EXP withaferin A results in decreased expression of TUBB mRNA CTD PMID:24297176 NCBI chr 6:30,720,352...30,725,422
Ensembl chr 6:30,720,352...30,725,426
Ensembl chr 6:30,720,352...30,725,426
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
decreases expression
EXP [withanone co-treated with withaferin A] results in decreased secretion of VEGFA protein; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]
withaferin A results in decreased expression of VEGFA protein
CTD PMID:20438634 PMID:25236891 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G XBP1 X-box binding protein 1 increases expression
increases splicing
EXP withaferin A results in increased expression of XBP1 protein
withaferin A results in increased splicing of XBP1 mRNA
CTD PMID:21266191 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24481
    chemical entity 24449
      molecular entity 24412
        polyatomic entity 24340
          heteroatomic molecular entity 23943
            hydroxides 22467
              organic hydroxy compound 20748
                hydroxy steroid 13242
                  27-hydroxy steroid 46
                    2,3-dihydro-3beta-O-sulfate withaferin A 0
                    2,3-dihydro-3beta-methoxy withaferin A 0
                    2,3-dihydrowithaferin A 0
                    3alpha,6alpha-epoxy-4beta,5beta,27-trihydroxy-1-oxowitha-24-enolide 0
                    5beta-cyprinol + 0
                    5beta-scymnol + 0
                    viscosalactone B 0
                    withaferin A + 46
                    withalongolide A 0
                    withalongolide C 0
                    withalongolide D 0
                    withalongolide E 0
                    withalongolide G 0
                    withalongolide I 0
                    yuccalan 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24481
    subatomic particle 24438
      composite particle 24438
        hadron 24438
          baryon 24438
            nucleon 24438
              atomic nucleus 24438
                atom 24438
                  main group element atom 24295
                    p-block element atom 24295
                      carbon group element atom 24079
                        carbon atom 24040
                          organic molecular entity 24040
                            organic molecule 23922
                              organic cyclic compound 23116
                                organic polycyclic compound 17737
                                  steroid 13721
                                    hydroxy steroid 13242
                                      27-hydroxy steroid 46
                                        2,3-dihydro-3beta-O-sulfate withaferin A 0
                                        2,3-dihydro-3beta-methoxy withaferin A 0
                                        2,3-dihydrowithaferin A 0
                                        3alpha,6alpha-epoxy-4beta,5beta,27-trihydroxy-1-oxowitha-24-enolide 0
                                        5beta-cyprinol + 0
                                        5beta-scymnol + 0
                                        viscosalactone B 0
                                        withaferin A + 46
                                        withalongolide A 0
                                        withalongolide C 0
                                        withalongolide D 0
                                        withalongolide E 0
                                        withalongolide G 0
                                        withalongolide I 0
                                        yuccalan 0
paths to the root