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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alpha-adrenergic antagonist
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Accession:CHEBI:37890 term browser browse the term
Definition:An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Synonyms:related_synonym: alpha-adrenergic antagonists;   alpha-adrenergic blocker;   alpha-adrenergic blockers;   alpha-adrenergic receptor blockaders;   alpha-adrenoceptor antagonists


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2-methoxyidazoxan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A affects binding
multiple interactions
ISO ADRA2A protein binds to 2-methoxyidazoxan
Epinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]; Norepinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]; Oxymetazoline inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]; xylometazoline inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]
CTD PMID:20030735 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2b adrenoceptor alpha 2B affects binding
multiple interactions
ISO ADRA2B protein binds to 2-methoxyidazoxan
Epinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]; Norepinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]; Oxymetazoline inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]; xylometazoline inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]
CTD PMID:20030735 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987
JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions
affects response to substance
affects binding
ISO Epinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]; Norepinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]; Oxymetazoline inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]; xylometazoline inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]
ADRA2C affects the susceptibility to 2-methoxyidazoxan
CTD PMID:10336518 PMID:20030735 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP 2-methoxyidazoxan inhibits the reaction [Epinephrine results in increased expression of CCND1 protein] CTD PMID:17680988 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
ajmalicine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions
ISO raubasine results in decreased activity of CYP2D6 protein
raubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]
CTD PMID:15930738 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
alfuzosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A affects binding
multiple interactions
EXP
ISO
alfuzosin binds to ADRA1A protein
alfuzosin inhibits the reaction [Prazosin binds to ADRA1A protein]
CTD PMID:7536677 PMID:8183249 PMID:8196478 PMID:21544540 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B affects binding ISO alfuzosin binds to ADRA1B protein CTD PMID:8183249 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding ISO
EXP
alfuzosin binds to ADRA1D protein CTD PMID:8183249 PMID:9294627 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP alfuzosin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein] CTD PMID:17240043 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP alfuzosin inhibits the reaction [Phenylephrine results in decreased secretion of GNRH1 protein]; alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of GNRH1 protein] CTD PMID:1975657 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of TAC1 protein] CTD PMID:17240043 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
decreases activity
ISO
EXP
ABCB1 protein results in increased transport of carvedilol
[Cyclosporine results in decreased activity of ABCB1 protein] which results in increased uptake of carvedilol
[carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]] which results in decreased susceptibility to Daunorubicin; [carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Doxorubicin]] which results in decreased susceptibility to Doxorubicin; [carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel]] which results in decreased susceptibility to Paclitaxel; [carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]] which results in decreased susceptibility to Vinblastine; [carvedilol results in decreased activity of ABCB1 protein] which results in increased susceptibility to Doxorubicin; [carvedilol results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Doxorubicin]; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel]; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of carvedilol]
CTD PMID:10571255 PMID:11895100 PMID:12708479 PMID:16671962 PMID:17609666 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP
ISO
carvedilol inhibits the reaction [Colchicine results in decreased activity of ACE protein]
carvedilol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ACE mRNA]
CTD PMID:15071347 PMID:18992766 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Carvedilol inhibits the reaction [Ethanol results in increased expression of ACTA2 mRNA]; Carvedilol inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]
carvedilol results in decreased expression of ACTA2 protein
CTD PMID:20403466 PMID:22413959 PMID:30254303 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actn4 actinin alpha 4 decreases expression EXP carvedilol results in decreased expression of ACTN4 protein CTD PMID:20403466 NCBI chr 1:87,078,012...87,147,347
Ensembl chr 1:87,078,020...87,147,333
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO carvedilol results in decreased expression of ADIPOQ protein CTD PMID:19367012 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions
decreases expression
ISO
EXP
Carvedilol binds to and results in decreased activity of ADRA1A protein; Carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]
carvedilol results in decreased expression of ADRA1A mRNA
CTD PMID:15306222 PMID:20668454 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions ISO carvedilol binds to and results in decreased activity of ADRA1B protein; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium] CTD PMID:15306222 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions ISO carvedilol binds to and results in decreased activity of ADRA1D protein; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium] CTD PMID:15306222 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions
affects binding
increases expression
increases phosphorylation
increases activity
affects response to substance
ISO
EXP
[ADRB1 gene co-treated with ADRB2 gene] affects the susceptibility to Carvedilol; [Carvedilol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; [Carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP; ADRB1 protein polymorphism affects the reaction [[Carvedilol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP]; ADRB1 protein polymorphism affects the susceptibility to [Carvedilol co-treated with Angiotensin Receptor Antagonists]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Carvedilol binds to and results in decreased activity of ADRB1 protein; Carvedilol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Carvedilol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Carvedilol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; Carvedilol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; CGP 20712A inhibits the reaction [[Carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP]; CGP 20712A inhibits the reaction [Carvedilol results in increased activity of ADRB1 protein]; Guanine Nucleotides affects the reaction [Carvedilol binds to ADRB1 protein]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
carvedilol binds to ADRB1 protein
carvedilol results in increased expression of ADRB1 mRNA
carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; carvedilol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]
[carvedilol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein; carvedilol results in increased phosphorylation of ADRB1 protein
carvedilol results in increased activity of ADRB1 protein
ADRB1 gene polymorphism affects the susceptibility to carvedilol; ADRB1 protein polymorphism affects the susceptibility to carvedilol
CTD PMID:1378154 PMID:2462161 PMID:7908256 PMID:10372227 PMID:12535855 PMID:12761341 PMID:14502278 PMID:14730417 PMID:15060759 PMID:15306222 PMID:16475467 PMID:17200720 PMID:18075464 PMID:18787115 PMID:20643254 PMID:20668454 PMID:21216836 PMID:21395649 PMID:21516734 PMID:21599570 PMID:22192668 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases phosphorylation
affects binding
increases expression
increases uptake
affects response to substance
ISO
EXP
[ADRB1 gene co-treated with ADRB2 gene] affects the susceptibility to carvedilol; [carvedilol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; [carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [carvedilol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; [carvedilol co-treated with ADRB2 protein] results in increased expression of GNAS protein; [carvedilol co-treated with ADRB2 protein] results in increased expression of GRK2 protein; carvedilol binds to and results in decreased activity of ADRB2 protein; carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; carvedilol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; carvedilol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]; Guanine Nucleotides affects the reaction [carvedilol binds to ADRB2 protein]; ICI 118551 inhibits the reaction [[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein]; ICI 118551 inhibits the reaction [[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein]; ICI 118551 inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]; Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]; Propranolol inhibits the reaction [carvedilol results in increased phosphorylation of ADRB2 protein]
carvedilol results in increased expression of ADRB2 mRNA
carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; carvedilol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]
carvedilol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]; carvedilol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein]
carvedilol results in increased uptake of ADRB2 protein
ADRB2 gene SNP affects the susceptibility to carvedilol; ADRB2 protein polymorphism affects the susceptibility to carvedilol
CTD PMID:1378154 PMID:2462161 PMID:10372227 PMID:10455254 PMID:12198331 PMID:12535855 PMID:12835612 PMID:14730417 PMID:15306222 PMID:16225854 PMID:17925438 PMID:19034036 PMID:19175363 PMID:19422106 PMID:20352314 PMID:20668454 PMID:21216836 PMID:21395649 PMID:21599570 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
decreases expression
affects response to substance
ISO
EXP
carvedilol inhibits the reaction [cyanopindolol binds to ADRB3 protein]
carvedilol results in decreased expression of ADRB3 mRNA
ADRB3 affects the susceptibility to carvedilol
CTD PMID:11159692 PMID:14730417 PMID:17440824 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Agt angiotensinogen multiple interactions
decreases response to substance
decreases expression
EXP
ISO
[Losartan co-treated with Carvedilol] results in decreased susceptibility to AGT protein modified form; Carvedilol inhibits the reaction [AGT protein affects the localization of RAC1 protein]; Carvedilol inhibits the reaction [AGT protein results in increased abundance of Glycerol]; Carvedilol inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]; Carvedilol inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; Carvedilol inhibits the reaction [Losartan results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [Carvedilol results in decreased susceptibility to AGT protein modified form]
carvedilol results in decreased susceptibility to AGT protein modified form
carvedilol inhibits the reaction [AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]]; carvedilol inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]
carvedilol results in decreased expression of AGT protein
CTD PMID:12004934 PMID:12538430 PMID:15741261 PMID:16794485 PMID:16940222 PMID:19183357 PMID:21047287 PMID:21166975 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP
ISO
carvedilol results in increased phosphorylation of AKT1 protein CTD PMID:27288437 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein decreases expression ISO carvedilol results in decreased expression of APP protein modified form CTD PMID:20579773 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA; [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA; [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA; [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA; [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR214 mRNA; ARRB1 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; carvedilol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; carvedilol promotes the reaction [ARRB1 protein binds to DROSHA protein]; carvedilol promotes the reaction [ARRB1 protein binds to HNRNPA1 protein]; Colforsin inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; GRK5 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; GRK6 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; Metoprolol inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]
ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125A mRNA]; ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]; ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR150 mRNA]; ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR214 mRNA]; carvedilol promotes the reaction [ARRB1 protein binds to DROSHA protein]; carvedilol promotes the reaction [ARRB1 protein binds to HNRNPA1 protein]
CTD PMID:18787115 PMID:24334028 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions
affects localization
ISO
EXP
ARRB2 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [carvedilol results in increased phosphorylation of MAPK1 protein]; ARRB2 protein promotes the reaction [carvedilol results in increased phosphorylation of MAPK3 protein]; carvedilol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]; ICI 118551 inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]; Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]
ARRB2 promotes the reaction [carvedilol results in increased uptake of Calcium]
carvedilol affects the localization of ARRB2 protein
CTD PMID:17925438 PMID:18787115 PMID:21078978 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions
increases expression
EXP carvedilol inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 mRNA]; carvedilol inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 protein]
carvedilol results in increased expression of ATP2A2 mRNA
CTD PMID:15670758 PMID:16026515 PMID:16162791 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Avp arginine vasopressin decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased expression of AVP protein
carvedilol inhibits the reaction [AVP protein results in increased import of and results in increased abundance of Calcium]
CTD PMID:12523682 PMID:14711191 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP [[Oxygen deficiency co-treated with Glucose deficiency] results in increased susceptibility to Carvedilol] which results in decreased expression of BAK1 mRNA CTD PMID:29122578 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
EXP
ISO
carvedilol inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; carvedilol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; carvedilol inhibits the reaction [Potassium Dichromate results in increased expression of BAX protein]
carvedilol inhibits the reaction [Cisplatin results in increased expression of BAX protein]
carvedilol results in increased expression of BAX protein
carvedilol results in decreased expression of BAX
CTD PMID:12973927 PMID:15380674 PMID:20079142 PMID:24012798 PMID:25245570 PMID:26036690 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
affects expression
EXP carvedilol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; carvedilol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; carvedilol inhibits the reaction [Potassium Dichromate results in decreased expression of BCL2 protein]
carvedilol results in increased expression of BCL2 mRNA
carvedilol affects the expression of BCL2 protein
CTD PMID:15380674 PMID:16780994 PMID:16909474 PMID:22000973 PMID:25245570 PMID:26036690 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP carvedilol results in increased expression of BCL2L1 protein CTD PMID:20079142 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Becn1 beclin 1 increases expression EXP carvedilol results in increased expression of BECN1 protein CTD PMID:20079142 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP capsazepine inhibits the reaction [carvedilol results in increased secretion of [CALCA protein co-treated with CALCB protein]]; carvedilol results in increased secretion of [CALCA protein co-treated with CALCB protein] CTD PMID:14764656 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Calcb calcitonin-related polypeptide, beta multiple interactions EXP capsazepine inhibits the reaction [carvedilol results in increased secretion of [CALCA protein co-treated with CALCB protein]]; carvedilol results in increased secretion of [CALCA protein co-treated with CALCB protein] CTD PMID:14764656 NCBI chr 1:184,271,116...184,276,480
Ensembl chr 1:184,271,590...184,276,475
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Carvedilol inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Carvedilol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Carvedilol inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Carvedilol inhibits the reaction [Potassium Dichromate results in increased cleavage of CASP3 protein]
carvedilol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]
carvedilol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]
CTD PMID:10728402 PMID:15380674 PMID:21044617 PMID:24012798 PMID:25245570 PMID:26036690 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
increases activity
EXP Carvedilol inhibits the reaction [Arginine results in decreased activity of CAT protein]; Carvedilol inhibits the reaction [Chlorpromazine results in decreased expression of CAT protein]; Carvedilol inhibits the reaction [Haloperidol results in decreased expression of CAT protein]; Carvedilol inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]
carvedilol results in increased activity of CAT protein
CTD PMID:12010767 PMID:16909474 PMID:25245570 PMID:32569593 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in decreased expression of CDH1 protein] CTD PMID:30254303 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cfl1 cofilin 1 decreases expression EXP carvedilol results in decreased expression of CFL1 protein CTD PMID:20403466 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of COL1A1 mRNA]; carvedilol inhibits the reaction [Ethanol results in increased expression of COL1A1 mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]
carvedilol decreases expression of collagen I mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats
Carvedilol results in decreased expression of COL1A1 mRNA; Carvedilol results in decreased expression of COL1A1 protein
CTD PMID:10722803 PMID:11181017 PMID:11682445 PMID:19575289 PMID:21216836 PMID:22413959, PMID:11682445 RGD:30296650 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of COL3A1 mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]
carvedilol decreases expression of collagen III mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats
carvedilol results in decreased expression of COL3A1 protein
CTD PMID:10722803 PMID:11181017 PMID:11682445, PMID:11682445 RGD:30296650 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Crp C-reactive protein decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased expression of CRP protein
Carvedilol inhibits the reaction [Arginine results in increased expression of CRP protein]
CTD PMID:15047035 PMID:32569593 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO carvedilol inhibits the reaction [CSF2 results in increased expression of IL10 mRNA]; carvedilol inhibits the reaction [CSF2 results in increased expression of IL10 protein] CTD PMID:12722941 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cycs cytochrome c, somatic increases expression EXP carvedilol results in increased expression of CYCS protein CTD PMID:18971572 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing EXP CYP2C11 protein results in increased metabolism of carvedilol CTD PMID:29415952 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 increases metabolic processing EXP CYP2D2 protein results in increased metabolism of carvedilol CTD PMID:29415952 NCBI chr 7:123,651,827...123,655,896
Ensembl chr 7:123,651,827...123,655,896
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects glucuronidation
affects metabolic processing
affects response to substance
ISO CYP2D6 gene polymorphism affects the glucuronidation of carvedilol
CYP2D6 gene polymorphism affects the metabolism of carvedilol; CYP2D6 protein polymorphism affects the metabolism of carvedilol
CYP2D6 gene polymorphism affects the susceptibility to carvedilol
CTD PMID:15001973 PMID:16595916 PMID:16849011 PMID:17329852 PMID:20643254 PMID:20686235 PMID:21599570 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing EXP CYP3A2 protein results in increased metabolism of carvedilol CTD PMID:29415952 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases metabolic processing EXP CYP3A23-3A1 protein results in increased metabolism of Carvedilol CTD PMID:29415952 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 decreases expression ISO carvedilol results in decreased expression of DDIT4 mRNA CTD PMID:27288437 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Drosha drosha ribonuclease III multiple interactions ISO carvedilol promotes the reaction [ARRB1 protein binds to DROSHA protein] CTD PMID:24334028 NCBI chr 2:62,887,267...63,000,307
Ensembl chr 2:62,887,267...62,999,572
JBrowse link
G Edn1 endothelin 1 decreases secretion
decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased secretion of EDN1 protein
carvedilol results in decreased expression of EDN1 mRNA
carvedilol inhibits the reaction [EDN1 protein results in increased import of and results in increased abundance of Calcium]
carvedilol results in decreased expression of EDN1 mRNA; carvedilol results in decreased expression of EDN1 protein
carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]; carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 protein]
CTD PMID:9500873 PMID:11078433 PMID:14711191 PMID:16428915 PMID:18971572 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
[carvedilol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein
CTD PMID:18787115 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP [irbesartan co-treated with carvedilol] results in decreased expression of F3 mRNA; [irbesartan co-treated with carvedilol] results in decreased expression of F3 protein CTD PMID:21229253 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO carvedilol inhibits the reaction [Epinephrine results in increased expression of FAS protein] CTD PMID:10728402 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO carvedilol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] CTD PMID:10728402 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP carvedilol inhibits the reaction [Ethanol results in increased expression of FASN mRNA] CTD PMID:22413959 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B multiple interactions ISO carvedilol promotes the reaction [FKBP1B protein binds to RYR2 protein] CTD PMID:12743001 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451
JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of FN1 mRNA]; carvedilol inhibits the reaction [Streptozocin results in increased expression of FN1 protein]
carvedilol decreases expression of fibronectin mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats
carvedilol results in decreased expression of FN1 protein
CTD PMID:11181017 PMID:11682445 PMID:12140129, PMID:11682445 RGD:30296650 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gap43 growth associated protein 43 decreases expression EXP carvedilol results in decreased expression of GAP43 mRNA; carvedilol results in decreased expression of GAP43 protein CTD PMID:20359859 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gata4 GATA binding protein 4 decreases phosphorylation EXP carvedilol results in decreased phosphorylation of GATA4 protein CTD PMID:21472269 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
affects localization
decreases phosphorylation
increases phosphorylation
decreases degradation
ISO
EXP
carvedilol results in increased expression of GJA1 mRNA; carvedilol results in increased expression of GJA1 protein
carvedilol affects the localization of GJA1 protein
carvedilol results in decreased phosphorylation of GJA1 protein
carvedilol results in increased phosphorylation of GJA1 protein
carvedilol results in decreased degradation of GJA1 protein
CTD PMID:16448880 PMID:16563290 PMID:17445419 PMID:18971572 PMID:19478468 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gja4 gap junction protein, alpha 4 increases expression EXP carvedilol results in increased expression of GJA4 protein CTD PMID:16448880 NCBI chr 5:145,374,688...145,377,221
Ensembl chr 5:145,374,690...145,377,221
JBrowse link
G Gnas GNAS complex locus multiple interactions
increases expression
ISO
EXP
[carvedilol co-treated with ADRB2 protein] results in increased expression of GNAS protein
carvedilol results in increased expression of GNAS mRNA
CTD PMID:10455254 PMID:20668454 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gpnmb glycoprotein nmb decreases expression EXP carvedilol results in decreased expression of GPNMB protein CTD PMID:20403466 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:30254303 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions
decreases expression
increases expression
ISO [carvedilol co-treated with ADRB2 protein] results in increased expression of GRK2 protein
carvedilol results in decreased expression of GRK2 protein
carvedilol results in increased expression of GRK2 protein
carvedilol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein]
CTD PMID:9788834 PMID:10455254 PMID:12198331 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 multiple interactions ISO GRK5 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]
GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125A mRNA]; GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]; GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR150 mRNA]; GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR214 mRNA]
CTD PMID:24334028 NCBI chr 1:282,265,371...282,467,842
Ensembl chr 1:282,265,370...282,462,605
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 multiple interactions ISO GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125A mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125B-1 mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR150 mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR214 mRNA]
GRK6 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]
CTD PMID:24334028 NCBI chr17:9,705,917...9,721,921
Ensembl chr17:9,703,453...9,721,574
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO HBEGF protein inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]] CTD PMID:18787115 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO carvedilol results in increased expression of HMOX1 mRNA CTD PMID:11688356 PMID:12227681 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 multiple interactions ISO carvedilol promotes the reaction [ARRB1 protein binds to HNRNPA1 protein] CTD PMID:24334028 NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585
JBrowse link
G Hpca hippocalcin affects localization EXP carvedilol affects the localization of HPCA protein CTD PMID:21078978 NCBI chr 5:147,295,124...147,305,757
Ensembl chr 5:147,294,820...147,303,346
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression EXP carvedilol results in increased expression of HSPH1 protein CTD PMID:20403466 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ifng interferon gamma multiple interactions ISO carvedilol inhibits the reaction [Hemagglutinins results in increased expression of IFNG protein] CTD PMID:15229385 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in increased expression of IKBKB protein] CTD PMID:26036690 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO
EXP
carvedilol inhibits the reaction [CSF2 results in increased expression of IL10 mRNA]; carvedilol inhibits the reaction [CSF2 results in increased expression of IL10 protein]
carvedilol results in increased expression of IL10 mRNA; carvedilol results in increased expression of IL10 protein
CTD PMID:12722941 PMID:16310260 PMID:18971572 PMID:20017808 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12a interleukin 12A multiple interactions ISO carvedilol promotes the reaction [Hemagglutinins results in increased expression of [IL12A protein binds to IL12B protein]]; carvedilol promotes the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:15229385 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO carvedilol promotes the reaction [Hemagglutinins results in increased expression of [IL12A protein binds to IL12B protein]]; carvedilol promotes the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:15229385 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased expression of IL1B mRNA
carvedilol results in decreased expression of IL1B mRNA; carvedilol results in decreased expression of IL1B protein
Carvedilol inhibits the reaction [Arginine results in increased expression of IL1B protein]; Carvedilol inhibits the reaction [Norepinephrine results in increased expression of IL1B mRNA]
carvedilol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD PMID:10722803 PMID:14684360 PMID:15921778 PMID:16310260 PMID:20017808 PMID:32569593 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression EXP carvedilol results in increased expression of IL1RN protein CTD PMID:20017808 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
EXP carvedilol results in decreased expression of IL6 mRNA; carvedilol results in decreased expression of IL6 protein
carvedilol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]
CTD PMID:10722803 PMID:11406463 PMID:16310260 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 decreases expression ISO carvedilol results in decreased expression of INS protein alternative form CTD PMID:16598518 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Jph2 junctophilin 2 increases expression ISO carvedilol results in increased expression of JPH2 protein CTD PMID:22375019 NCBI chr 3:159,709,998...159,776,536
Ensembl chr 3:159,712,325...159,775,643
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 multiple interactions EXP carvedilol binds to and results in decreased activity of KCNA5 protein CTD PMID:22146582 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
affects activity
ISO carvedilol results in decreased activity of KCNH2 protein
carvedilol affects the activity of KCNH2 protein
CTD PMID:11164846 PMID:16314852 PMID:22020101 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 decreases activity ISO carvedilol results in decreased activity of KCNJ11 protein CTD PMID:16325804 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 multiple interactions ISO carvedilol binds to and results in decreased activity of KCNJ4 protein; Phosphatidylinositol Phosphates inhibits the reaction [carvedilol binds to and results in decreased activity of KCNJ4 protein] CTD PMID:21663737 NCBI chr 7:120,717,378...120,744,602
Ensembl chr 7:120,717,375...120,744,602
JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 decreases activity ISO carvedilol results in decreased activity of KCNK3 protein CTD PMID:21410455 NCBI chr 6:27,154,274...27,190,209
Ensembl chr 6:27,151,612...27,190,132
JBrowse link
G Klf13 Kruppel-like factor 13 multiple interactions EXP [[Oxygen deficiency co-treated with Glucose deficiency] results in increased susceptibility to Carvedilol] which results in decreased expression of KLF13 mRNA CTD PMID:29122578 NCBI chr 1:124,772,596...124,803,363
Ensembl chr 1:124,772,596...124,803,363
JBrowse link
G Lox lysyl oxidase decreases expression EXP carvedilol results in decreased expression of LOX mRNA CTD PMID:21216836 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
[Doxorubicin co-treated with carvedilol] results in increased phosphorylation of MAPK1 protein; carvedilol inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK1 protein]
Erlotinib Hydrochloride inhibits the reaction [carvedilol results in increased phosphorylation of MAPK1 protein]
[Carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Carvedilol results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ICI 118551 inhibits the reaction [[Carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]
CTD PMID:11054474 PMID:15306222 PMID:16213474 PMID:17925438 PMID:18787115 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK14 protein] CTD PMID:16213474 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
[Doxorubicin co-treated with carvedilol] results in increased phosphorylation of MAPK3 protein; carvedilol inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK3 protein]
carvedilol results in increased phosphorylation of MAPK3 protein
Erlotinib Hydrochloride inhibits the reaction [carvedilol results in increased phosphorylation of MAPK3 protein]
[Carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Carvedilol results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ICI 118551 inhibits the reaction [[Carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]
CTD PMID:11054474 PMID:15306222 PMID:16213474 PMID:17925438 PMID:18787115 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mfge8 milk fat globule EGF and factor V/VIII domain containing decreases expression EXP carvedilol results in decreased expression of MFGE8 protein CTD PMID:20403466 NCBI chr 1:140,845,478...140,860,882
Ensembl chr 1:140,845,465...140,860,894
JBrowse link
G Mir125a microRNA 125a multiple interactions
increases expression
ISO [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA
ARRB1 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125A mRNA]; GRK5 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125A mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125A mRNA]
carvedilol results in increased expression of MIR125A mRNA
CTD PMID:24334028 NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911
JBrowse link
G Mir125b1 microRNA 125b-1 multiple interactions
increases expression
ISO ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]; GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]; GRK6 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]
[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA
CTD PMID:24334028 NCBI chr 8:45,798,260...45,798,346
Ensembl chr 8:45,798,260...45,798,346
JBrowse link
G Mir125b2 microRNA 125b-2 increases expression ISO Carvedilol results in increased expression of MIR125B2 mRNA CTD PMID:29122578 NCBI chr11:16,097,346...16,097,433 JBrowse link
G Mir150 microRNA 150 multiple interactions
increases expression
ISO [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA
ARRB1 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR150 mRNA]; GRK5 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR150 mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR150 mRNA]
CTD PMID:24334028 NCBI chr 1:101,115,974...101,116,058
Ensembl chr 1:101,115,974...101,116,058
JBrowse link
G Mir190 microRNA 190 multiple interactions ISO [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA; Colforsin inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; GRK5 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; GRK6 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; Metoprolol inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA] CTD PMID:24334028 NCBI chr 8:73,030,047...73,030,131
Ensembl chr 8:73,030,047...73,030,131
JBrowse link
G Mir200a microRNA 200a multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in decreased expression of MIR200A mRNA] CTD PMID:30254303 NCBI chr 5:173,489,366...173,489,454 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression
EXP
ISO
carvedilol inhibits the reaction [Doxorubicin results in increased expression of MMP2 mRNA]
carvedilol results in decreased activity of MMP2 protein
carvedilol inhibits the reaction [TNF protein results in increased expression of MMP2 protein]
carvedilol results in decreased expression of MMP2
CTD PMID:16213474 PMID:16310260 PMID:17964422 PMID:20452391 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases expression ISO carvedilol results in decreased expression of MMP8 mRNA CTD PMID:15921778 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Mmp9 matrix metallopeptidase 9 affects activity
decreases expression
decreases activity
multiple interactions
ISO
EXP
carvedilol affects the activity of MMP9 protein
carvedilol results in decreased expression of MMP9 mRNA
carvedilol results in decreased activity of MMP9 protein
carvedilol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
carvedilol inhibits the reaction [Doxorubicin results in increased expression of MMP9 mRNA]
CTD PMID:16213474 PMID:16310260 PMID:16574429 PMID:17964422 PMID:18971572 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
carvedilol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of MPO protein]
Carvedilol inhibits the reaction [Arginine results in increased expression of MPO protein]
carvedilol inhibits the reaction [Calcimycin results in increased secretion of MPO protein]; carvedilol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein]; carvedilol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MPO protein]
CTD PMID:16601795 PMID:17159805 PMID:18987595 PMID:32569593 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Msn moesin decreases expression EXP carvedilol results in decreased expression of MSN protein CTD PMID:20403466 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810
JBrowse link
G Mstn myostatin decreases expression EXP carvedilol results in decreased expression of MSTN mRNA; carvedilol results in decreased expression of MSTN protein CTD PMID:16968467 NCBI chr 9:53,310,977...53,315,804
Ensembl chr 9:53,309,598...53,315,915
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
affects expression
EXP carvedilol results in decreased expression of MYC protein
carvedilol affects the expression of MYC protein
CTD PMID:21472269 PMID:22000973 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myl12a myosin light chain 12A decreases expression EXP carvedilol results in decreased expression of MYL12A protein CTD PMID:20403466 NCBI chr 9:119,325,282...119,333,012
Ensembl chr 9:119,325,283...119,332,967
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 increases phosphorylation EXP carvedilol results in increased phosphorylation of NFATC4 protein CTD PMID:21472269 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Atenolol inhibits the reaction [carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; carvedilol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; carvedilol inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; carvedilol promotes the reaction [wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Prazosin inhibits the reaction [carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
carvedilol inhibits the reaction [Potassium Dichromate results in increased expression of NOS2 protein]
CTD PMID:17159805 PMID:19439816 PMID:25245570 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
increases phosphorylation
decreases expression
EXP carvedilol results in increased expression of NOS3 mRNA; carvedilol results in increased expression of NOS3 protein
carvedilol results in increased phosphorylation of NOS3 protein
carvedilol results in decreased expression of NOS3 mRNA
CTD PMID:16741616 PMID:17559835 PMID:18971572 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] CTD PMID:16213474 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nppa natriuretic peptide A decreases expression
increases expression
decreases degradation
multiple interactions
ISO
EXP
carvedilol results in decreased expression of NPPA protein
carvedilol results in increased expression of NPPA mRNA; carvedilol results in increased expression of NPPA protein
carvedilol results in decreased expression of NPPA mRNA
carvedilol results in decreased degradation of NPPA protein
carvedilol inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; carvedilol promotes the reaction [NPPA protein results in increased abundance of Cyclic GMP]
CTD PMID:1378157 PMID:9421401 PMID:10722803 PMID:11206715 PMID:21216836 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression
increases expression
ISO
EXP
[carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein
carvedilol inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]
carvedilol results in decreased expression of NPPB protein
carvedilol results in decreased expression of NPPB mRNA; carvedilol results in decreased expression of NPPB protein
carvedilol results in increased expression of NPPB mRNA
CTD PMID:11206715 PMID:19367012 PMID:19650993 PMID:19692266 PMID:20413026 PMID:21055277 PMID:21378469 PMID:26036690 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Npr3 natriuretic peptide receptor 3 decreases expression EXP carvedilol results in decreased expression of NPR3 mRNA CTD PMID:9421401 PMID:11206715 NCBI chr 2:61,883,946...61,950,291
Ensembl chr 2:61,888,950...61,949,926
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in increased expression of OLR1 mRNA]; carvedilol inhibits the reaction [Doxorubicin results in increased expression of OLR1 protein]; carvedilol inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 mRNA]; carvedilol inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 protein] CTD PMID:16055083 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO carvedilol results in decreased susceptibility to [PDGFB protein binds to PDGFB protein] CTD PMID:11904532 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pgd phosphogluconate dehydrogenase multiple interactions EXP carvedilol inhibits the reaction [Norepinephrine results in increased activity of PGD mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased activity of PGD protein] CTD PMID:1378361 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP carvedilol inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:22413959 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP carvedilol results in increased expression of PPARGC1A mRNA CTD PMID:18971572 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prkca protein kinase C, alpha decreases expression EXP carvedilol results in decreased expression of PRKCA protein CTD PMID:20668454 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcd protein kinase C, delta decreases expression EXP carvedilol results in decreased expression of PRKCD protein CTD PMID:20668454 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkce protein kinase C, epsilon increases activity EXP carvedilol results in increased activity of PRKCE protein CTD PMID:16782078 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions EXP Carvedilol inhibits the reaction [Arginine results in increased expression of PTAFR mRNA] CTD PMID:32569593 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression EXP carvedilol results in decreased expression of PTGS1 mRNA CTD PMID:16741616 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP carvedilol inhibits the reaction [AGT protein affects the localization of RAC1 protein] CTD PMID:16940222 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Reg3b regenerating family member 3 beta multiple interactions EXP Carvedilol inhibits the reaction [Arginine results in increased expression of REG3B mRNA] CTD PMID:32569593 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Carvedilol inhibits the reaction [Arginine results in increased expression of RELA protein]; Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of RELA protein]; Carvedilol inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Carvedilol inhibits the reaction [Potassium Dichromate affects the localization of RELA protein] CTD PMID:25245570 PMID:26036690 PMID:30254303 PMID:32569593 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin decreases expression ISO carvedilol results in decreased expression of REN protein CTD PMID:2454358 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Ryr2 ryanodine receptor 2 affects activity
increases expression
multiple interactions
increases activity
ISO
EXP
carvedilol affects the activity of RYR2 protein; carvedilol analog affects the activity of RYR2 protein
carvedilol results in increased expression of RYR2 protein
[Huang Qi co-treated with carvedilol] results in increased expression of RYR2 mRNA
carvedilol promotes the reaction [Perindopril results in increased expression of RYR2 protein]; Perindopril promotes the reaction [carvedilol results in increased expression of RYR2 protein]
carvedilol results in increased expression of RYR2 mRNA
carvedilol results in increased activity of RYR2 protein
carvedilol inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein]; carvedilol promotes the reaction [FKBP1B protein binds to RYR2 protein]
CTD PMID:12743001 PMID:19620082 PMID:21743453 PMID:21924056 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G S100a10 S100 calcium binding protein A10 decreases expression EXP carvedilol results in decreased expression of S100A10 protein CTD PMID:20403466 NCBI chr 2:193,892,589...193,901,236
Ensembl chr 2:193,892,589...193,901,236
JBrowse link
G S100a11 S100 calcium binding protein A11 decreases expression EXP carvedilol results in decreased expression of S100A11 protein CTD PMID:20403466 NCBI chr 2:193,863,185...193,868,646
Ensembl chr 2:193,866,951...193,868,502
JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression EXP carvedilol results in decreased expression of S100A6 protein CTD PMID:20403466 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions EXP carvedilol inhibits the reaction [Norepinephrine results in increased expression of SERPINH1 mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased expression of SERPINH1 protein] CTD PMID:10722803 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO carvedilol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Carvedilol inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Carvedilol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Carvedilol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin] CTD PMID:19740083 PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO carvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; carvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] CTD PMID:21641380 PMID:21697722 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO carvedilol inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Smad7 SMAD family member 7 multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein] CTD PMID:30254303 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein] CTD PMID:26036690 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression EXP
ISO
carvedilol results in increased expression of SOX2 mRNA CTD PMID:27288437 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP carvedilol inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] CTD PMID:22413959 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions EXP Carvedilol inhibits the reaction [Arginine results in increased expression of STAT1 protein] CTD PMID:32569593 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Terf2 telomeric repeat binding factor 2 affects expression EXP carvedilol affects the expression of TERF2 protein CTD PMID:22000973 NCBI chr19:39,271,992...39,301,506
Ensembl chr19:39,272,499...39,300,893
JBrowse link
G Tfpi tissue factor pathway inhibitor multiple interactions EXP [irbesartan co-treated with carvedilol] results in decreased expression of TFPI mRNA; [irbesartan co-treated with carvedilol] results in decreased expression of TFPI protein CTD PMID:21229253 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased expression of TGFB1 mRNA
carvedilol decreases expression of TGFbeta mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats
carvedilol results in decreased expression of TGFB1 mRNA; carvedilol results in decreased expression of TGFB1 protein
Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TGFB1 mRNA]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]; Carvedilol inhibits the reaction [Sodium, Dietary results in increased expression of TGFB1 mRNA]
CTD PMID:11682445 PMID:11688356 PMID:12227681 PMID:15921778 PMID:16310260 PMID:19692266 PMID:22413959 PMID:30254303, PMID:11682445 RGD:30296650 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [Ethanol results in increased expression of TH protein]
carvedilol results in decreased expression of TH mRNA; carvedilol results in decreased expression of TH protein
CTD PMID:20359859 PMID:22413959 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [Ethanol results in increased expression of TIMP1 mRNA]; carvedilol inhibits the reaction [Ethanol results in increased expression of TIMP1 protein]
carvedilol results in decreased expression of TIMP1 mRNA
CTD PMID:21216836 PMID:22413959 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; carvedilol inhibits the reaction [TNF protein results in increased expression of MMP2 protein]; carvedilol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
carvedilol results in decreased expression of TNF mRNA; carvedilol results in decreased expression of TNF protein
Carvedilol inhibits the reaction [Arginine results in increased expression of TNF protein]; Carvedilol inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TNF protein]; Carvedilol inhibits the reaction [Potassium Dichromate results in increased expression of TNF protein]
CTD PMID:15229385 PMID:16310260 PMID:17964422 PMID:20017808 PMID:22413959 PMID:25245570 PMID:26036690 PMID:32569593 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 affects expression
multiple interactions
EXP carvedilol affects the expression of TP53 protein
carvedilol inhibits the reaction [Potassium Dichromate results in increased expression of TP53 protein]
CTD PMID:22000973 PMID:25245570 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txn1 thioredoxin 1 increases expression EXP carvedilol results in increased expression of TXN1 protein CTD PMID:20403466 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
affects metabolic processing
affects glucuronidation
ISO UGT1A1 protein results in increased glucuronidation of carvedilol
UGT1A1 gene polymorphism affects the metabolism of carvedilol
UGT1A1 gene polymorphism affects the glucuronidation of carvedilol
CTD PMID:14744946 PMID:16849011 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation
affects glucuronidation
affects metabolic processing
ISO UGT2B7 protein results in increased glucuronidation of carvedilol
UGT2B7 gene polymorphism affects the glucuronidation of carvedilol
UGT2B7 gene polymorphism affects the metabolism of carvedilol
CTD PMID:14744946 PMID:16849011 PMID:17329852 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Vim vimentin multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased expression of VIM protein]; Carvedilol inhibits the reaction [Streptozocin results in increased expression of VIM protein] CTD PMID:12140129 PMID:30254303 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
clopenthixol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Clopenthixol results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
desipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases activity ISO Desipramine results in increased activity of ACHE protein CTD PMID:29614332 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alpp alkaline phosphatase, placental multiple interactions ISO Desipramine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Desipramine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA] CTD PMID:16036225 NCBI chr 9:94,189,961...94,193,054
Ensembl chr 9:94,190,067...94,192,813
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP Desipramine results in increased expression of ARC mRNA CTD PMID:14580947 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Desipramine results in increased expression of BCL2 mRNA; Desipramine results in increased expression of BCL2 protein CTD PMID:17510525 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO Desipramine results in increased expression of BDNF mRNA CTD PMID:15555640 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 decreases expression ISO Desipramine results in decreased expression of CAMKK1 mRNA CTD PMID:15555640 NCBI chr10:59,585,023...59,608,180
Ensembl chr10:59,585,072...59,608,165
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 decreases expression ISO Desipramine results in decreased expression of CAMKK2 mRNA CTD PMID:15555640 NCBI chr12:39,253,409...39,302,601
Ensembl chr12:39,253,409...39,302,601
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester promotes the reaction [Desipramine results in increased cleavage of and results in increased activity of CASP3 protein]; Desipramine results in increased cleavage of and results in increased activity of CASP3 protein
Desipramine results in increased activity of CASP3 protein
CTD PMID:18606486 PMID:18986328 PMID:20549303 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity EXP Desipramine results in increased activity of CASP9 protein CTD PMID:20549303 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Desipramine inhibits the reaction [TNF protein results in increased expression of CCL5 protein] CTD PMID:17477857 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression EXP Desipramine results in increased expression of CREB1 mRNA CTD PMID:8601816 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Desipramine results in decreased activity of CYP2C19 protein CTD PMID:15135088 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Desipramine CTD PMID:15286053 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Desipramine results in decreased activity of CYP2E1 protein CTD PMID:15135088 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH protein results in increased susceptibility to Desipramine CTD PMID:15148402 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects response to substance
increases expression
EXP DDIT3 affects the susceptibility to Desipramine
Desipramine results in increased expression of DDIT3 protein
CTD PMID:20549303 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Egr1 early growth response 1 decreases expression EXP Desipramine results in decreased expression of EGR1 mRNA CTD PMID:7612155 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Desipramine results in decreased expression of FOS mRNA CTD PMID:7612155 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions EXP Desipramine inhibits the reaction [Reserpine results in increased expression of GAL mRNA] CTD PMID:1717808 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 affects localization EXP Desipramine affects the localization of GRK2 protein CTD PMID:12527474 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 affects localization EXP Desipramine affects the localization of GRK3 protein CTD PMID:12527474 NCBI chr12:49,626,871...49,750,389
Ensembl chr12:49,626,871...49,746,272
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
increases expression
ISO
EXP
Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A mRNA]; Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A protein]
Desipramine results in increased expression of HTR1A protein
CTD PMID:1589591 PMID:15885359 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases expression EXP Desipramine results in decreased expression of HTR2A; Desipramine results in decreased expression of HTR2A protein CTD PMID:1664741 PMID:2553044 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Il1b interleukin 1 beta increases secretion EXP Desipramine results in increased secretion of IL1B protein CTD PMID:16386803 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Desipramine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; Desipramine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 protein]; Desipramine inhibits the reaction [TNF protein results in increased expression of IL6 protein] CTD PMID:24951586 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Desipramine results in decreased activity of KCNH2 protein CTD PMID:20211602 PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity ISO Desipramine results in increased activity of MAPK1 protein CTD PMID:18986328 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases activity ISO Desipramine results in increased activity of MAPK14 protein CTD PMID:18986328 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity ISO Desipramine results in increased activity of MAPK3 protein CTD PMID:18986328 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester promotes the reaction [Desipramine results in increased phosphorylation of MAPK8 protein] CTD PMID:18606486 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Nes nestin increases expression EXP Desipramine results in increased expression of NES mRNA CTD PMID:17510525 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to Desipramine CTD PMID:21540358 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 mRNA]; Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 protein] CTD PMID:15885359 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Plcb1 phospholipase C beta 1 decreases expression EXP Desipramine results in decreased expression of PLCB1 mRNA; Desipramine results in decreased expression of PLCB1 protein CTD PMID:12527476 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression EXP Desipramine results in increased expression of PPP1R15A protein CTD PMID:20549303 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO Desipramine inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:74,578,600...74,706,068
Ensembl chr  X:74,577,131...74,706,214
JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression ISO Desipramine results in increased expression of SLC17A7 mRNA; Desipramine results in increased expression of SLC17A7 protein CTD PMID:16111724 NCBI chr 1:101,161,265...101,172,292
Ensembl chr 1:101,161,252...101,173,174
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Desipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions EXP
ISO
Desipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Desipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]
CTD PMID:9830022 PMID:10966924 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions
decreases activity
decreases expression
ISO
EXP
Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]
Desipramine results in decreased activity of SLC6A2 protein
[Desipramine binds to and results in decreased activity of SLC6A2 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium; [Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine; Bupivacaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]; Lidocaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]; tricaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]
Desipramine results in decreased expression of SLC6A2 protein
CTD PMID:16725121 PMID:17234900 PMID:18561912 PMID:18923402 PMID:19616025 PMID:20079841 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 decreases activity ISO Desipramine results in decreased activity of SMPD1 protein CTD PMID:15781658 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions ISO Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] CTD PMID:17234900 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Desipramine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Desipramine inhibits the reaction [Reserpine results in increased expression of TH mRNA] CTD PMID:1717808 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor decreases activity
multiple interactions
ISO Desipramine results in decreased activity of TNF protein
Desipramine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Desipramine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Desipramine inhibits the reaction [TNF protein results in increased expression of IL6 protein]
CTD PMID:17477857 PMID:24951586 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
doxazosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Doxazosin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Adra1a adrenoceptor alpha 1A affects binding EXP
ISO
Doxazosin binds to ADRA1A protein CTD PMID:7536677 PMID:8183249 PMID:21544540 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B affects binding ISO Doxazosin binds to ADRA1B protein CTD PMID:8183249 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding ISO
EXP
Doxazosin binds to ADRA1D protein CTD PMID:8183249 PMID:9294627 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions
decreases expression
increases activity
ISO Doxazosin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]
Doxazosin results in decreased expression of ADRA2A protein
Doxazosin results in increased activity of ADRA2A protein
CTD PMID:10694191 PMID:10742289 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adrb1 adrenoceptor beta 1 increases expression EXP Doxazosin results in increased expression of ADRB1 protein CTD PMID:18084315 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression EXP Doxazosin results in increased expression of ADRB2 protein CTD PMID:18084315 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation EXP Doxazosin affects the phosphorylation of AKT1 protein CTD PMID:18084315 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Doxazosin results in increased expression of BAX protein
SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of BAX protein]
CTD PMID:16007219 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO BCL2 inhibits the reaction [Doxazosin results in decreased expression of VEGFA] CTD PMID:12576871 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Doxazosin results in increased activity of CASP3 protein
Doxazosin results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:12771931 PMID:15221243 PMID:22845314 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Doxazosin results in decreased expression of CCNA2 protein CTD PMID:15371785 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Doxazosin results in increased expression of CDKN1A mRNA CTD PMID:12771931 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Doxazosin inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA] CTD PMID:19575289 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Crp C-reactive protein decreases expression ISO Doxazosin results in decreased expression of CRP protein CTD PMID:16680063 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Doxazosin results in increased expression of DDIT3 protein CTD PMID:22845314 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Epha2 Eph receptor A2 multiple interactions ISO [Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein] which results in increased phosphorylation of and results in increased activity of PTPN11 protein; Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein; Lithocholic Acid inhibits the reaction [Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein] CTD PMID:22845314 NCBI chr 5:159,845,773...159,874,203
Ensembl chr 5:159,845,774...159,874,206
JBrowse link
G Faslg Fas ligand increases expression ISO Doxazosin results in increased expression of FASLG mRNA CTD PMID:12771931 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Klf10 Kruppel-like factor 10 increases expression ISO Doxazosin results in increased expression of KLF10 mRNA; Doxazosin results in increased expression of KLF10 protein CTD PMID:12771931 NCBI chr 7:77,156,010...77,162,096
Ensembl chr 7:77,156,006...77,162,148
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation EXP Doxazosin affects the phosphorylation of MAPK1 protein CTD PMID:18084315 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation EXP Doxazosin affects the phosphorylation of MAPK3 protein CTD PMID:18084315 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mstn myostatin decreases expression EXP Doxazosin results in decreased expression of MSTN mRNA; Doxazosin results in decreased expression of MSTN protein CTD PMID:16968467 NCBI chr 9:53,310,977...53,315,804
Ensembl chr 9:53,309,598...53,315,915
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Doxazosin results in increased expression of NFKBIA mRNA; Doxazosin results in increased expression of NFKBIA protein CTD PMID:12771931 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nppb natriuretic peptide B increases expression
multiple interactions
ISO
EXP
Doxazosin results in increased expression of NPPB protein
[Atenolol co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA
CTD PMID:15969258 PMID:18551024 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression
increases cleavage
ISO Doxazosin results in decreased expression of PTK2 protein
Doxazosin results in increased cleavage of PTK2 protein
CTD PMID:15221243 PMID:22845314 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions ISO [Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein] which results in increased phosphorylation of and results in increased activity of PTPN11 protein CTD PMID:22845314 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation
decreases phosphorylation
EXP
ISO
Doxazosin affects the phosphorylation of RB1 protein
Doxazosin results in decreased phosphorylation of RB1 protein
CTD PMID:15371785 PMID:18084315 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Ren renin increases expression ISO Doxazosin results in increased expression of REN protein CTD PMID:7818152 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Serpinb5 serpin family B member 5 multiple interactions
increases response to substance
ISO SERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA mRNA alternative form]; SERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA protein]; SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of BAX protein]; SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 mRNA]; SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 protein]
SERPINB5 protein results in increased susceptibility to Doxazosin
CTD PMID:16007219 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Doxazosin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Smad4 SMAD family member 4 increases expression
multiple interactions
ISO Doxazosin results in increased expression of SMAD4 mRNA; Doxazosin results in increased expression of SMAD4 protein
SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 mRNA]; SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 protein]
CTD PMID:12771931 PMID:16007219 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO BCL2 inhibits the reaction [Doxazosin results in decreased expression of VEGFA]; SERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA mRNA alternative form]; SERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA protein]
Doxazosin results in decreased expression of VEGFA mRNA; Doxazosin results in decreased expression of VEGFA mRNA alternative form; Doxazosin results in decreased expression of VEGFA protein
CTD PMID:12576871 PMID:16007219 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
flupenthixol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
ISO Flupenthixol analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Flupenthixol analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]
Flupenthixol analog results in decreased activity of ABCB1 protein; Flupenthixol analog results in decreased activity of ABCB1 protein mutant form
CTD PMID:7905786 PMID:12711602 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Drd1 dopamine receptor D1 affects binding ISO Flupenthixol binds to DRD1 protein CTD PMID:1352677 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Flupenthixol results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Flupenthixol results in decreased expression of PTGS1 protein CTD PMID:8897462 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Flupenthixol results in decreased expression of PTGS2 protein CTD PMID:8897462 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
idazoxan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A multiple interactions EXP [Idazoxan binds to and results in decreased activity of ADRA2A protein] which results in decreased susceptibility to amitraz CTD PMID:10582558 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions EXP [Imipramine co-treated with Idazoxan] results in decreased activity of ADRB1 protein CTD PMID:2868116 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Crh corticotropin releasing hormone decreases expression EXP Idazoxan results in decreased expression of CRH mRNA CTD PMID:1351783 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Idazoxan inhibits the reaction [Bee Venoms promotes the reaction [Methamphetamine results in increased expression of FOS protein]] CTD PMID:20950675 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gad2 glutamate decarboxylase 2 multiple interactions EXP [methylhistaprodifen co-treated with Idazoxan] inhibits the reaction [amitraz affects the expression of GAD2 mRNA]; Idazoxan inhibits the reaction [amitraz affects the expression of GAD2 mRNA] CTD PMID:26141220 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Gh1 growth hormone 1 decreases expression EXP Idazoxan results in decreased expression of GH1 protein CTD PMID:6150737 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gls glutaminase multiple interactions EXP [methylhistaprodifen co-treated with Idazoxan] inhibits the reaction [amitraz results in increased expression of GLS mRNA] CTD PMID:26141220 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression EXP Idazoxan results in increased expression of NR3C1 mRNA CTD PMID:1351783 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Prl prolactin decreases secretion EXP Idazoxan results in decreased secretion of PRL protein CTD PMID:1678730 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions
increases activity
ISO [Idazoxan results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP CTD PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link
G Th tyrosine hydroxylase increases expression EXP Idazoxan results in increased expression of TH mRNA CTD PMID:1351783 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
ketanserin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions ISO
EXP
Ketanserin inhibits the reaction [Prazosin binds to ADRA1A protein]
Ketanserin binds to and results in decreased activity of ADRA1A protein
CTD PMID:11937776 PMID:16545797 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions ISO Ketanserin inhibits the reaction [Prazosin binds to ADRA1B protein] CTD PMID:11937776 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions ISO Ketanserin inhibits the reaction [Prazosin binds to ADRA1D protein] CTD PMID:11937776 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein] CTD PMID:22975078 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP [Fluoxetine co-treated with Ketanserin] results in increased expression of BDNF mRNA CTD PMID:21627639 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Fluoxetine co-treated with Ketanserin] results in increased expression of CTNNB1 mRNA CTD PMID:21627639 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ddc dopa decarboxylase increases activity ISO Ketanserin results in increased activity of DDC protein CTD PMID:16415089 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
decreases activity
affects binding
ISO
EXP
Aripiprazole inhibits the reaction [Ketanserin binds to HTR2A protein]; Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]; Ketanserin binds to and results in decreased activity of HTR2A protein; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Ketanserin binds to HTR2A protein]; Quetiapine Fumarate inhibits the reaction [Ketanserin binds to HTR2A protein]; Spiperone inhibits the reaction [Ketanserin binds to HTR2A protein]; ziprasidone inhibits the reaction [Ketanserin binds to HTR2A protein]
Ketanserin results in decreased activity of HTR2A protein
8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Ketanserin binds to HTR2A protein]; [Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in decreased abundance of Serotonin]; [Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in increased secretion of Corticosterone]; [Ketanserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Serotonin; Diazinon promotes the reaction [Ketanserin binds to HTR2A protein]; Ketanserin binds to and results in decreased activity of HTR2A protein; Ketanserin inhibits the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]; Ketanserin inhibits the reaction [Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]]; Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]; Risperidone inhibits the reaction [Ketanserin binds to HTR2A protein]
cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Ketanserin binds to HTR2A protein]; HU 211 inhibits the reaction [Ketanserin binds to HTR2A protein]; Ketanserin binds to and results in decreased activity of HTR2A protein
CTD PMID:2891550 PMID:10773215 PMID:10978843 PMID:11927170 PMID:16314884 PMID:16528294 PMID:17031071 PMID:17035140 PMID:18417104 PMID:18784348 PMID:19879056 PMID:20600638 PMID:22048642 PMID:29458138 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO [Ketanserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP] CTD PMID:14578406 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Ketanserin inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:11076827 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]] CTD PMID:22975078 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Ketanserin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein] CTD PMID:22048642 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Ketanserin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein] CTD PMID:22048642 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Ketanserin inhibits the reaction [Tobacco Smoke Pollution affects the localization of NFE2L2 protein] CTD PMID:22048642 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO Ketanserin inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] CTD PMID:11880652 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects binding
multiple interactions
ISO Ketanserin binds to SLC6A4 protein
methamidophos inhibits the reaction [Ketanserin binds to SLC6A4 protein]
CTD PMID:21871486 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta multiple interactions ISO [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]] CTD PMID:22975078 NCBI chr 3:160,391,108...160,399,931
Ensembl chr 3:160,391,106...160,399,931
JBrowse link
labetalol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Labetalol results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases activity ISO Labetalol results in increased activity of ACE2 protein CTD PMID:21859683 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Adrb1 adrenoceptor beta 1 decreases activity
affects binding
increases activity
multiple interactions
ISO
EXP
Labetalol results in decreased activity of ADRB1 protein
Labetalol binds to ADRB1 protein
Labetalol results in increased activity of ADRB1 protein
[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP; CGP 20712A inhibits the reaction [[Labetalol co-treated with ADRB1] results in increased abundance of Cyclic AMP]; CGP 20712A inhibits the reaction [Labetalol results in increased activity of ADRB1 protein]
Labetalol binds to and results in decreased activity of ADRB1 protein; Labetalol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]
CTD PMID:2462161 PMID:2567112 PMID:11425575 PMID:11483288 PMID:12761341 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 decreases activity
affects binding
multiple interactions
ISO
EXP
Labetalol results in decreased activity of ADRB2 protein
Labetalol binds to ADRB2 protein
[Labetalol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Labetalol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Labetalol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein
Labetalol binds to and results in decreased activity of ADRB2 protein; Labetalol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]
CTD PMID:2462161 PMID:2567112 PMID:11425575 PMID:11483288 PMID:17925438 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Agt angiotensinogen decreases expression ISO Labetalol results in decreased expression of AGT protein CTD PMID:14627 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Avp arginine vasopressin multiple interactions ISO [Labetalol co-treated with Isoflurane] results in increased expression of AVP protein CTD PMID:1897344 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Labetalol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein CTD PMID:17925438 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Labetalol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nppa natriuretic peptide A decreases activity ISO Labetalol results in decreased activity of NPPA protein CTD PMID:2524958 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Prl prolactin multiple interactions
increases expression
ISO carbidopa, levodopa drug combination inhibits the reaction [Labetalol results in increased expression of PRL protein] CTD PMID:7105431 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ren renin multiple interactions
decreases activity
ISO [Labetalol co-treated with Isoflurane] results in increased expression of REN protein
Labetalol results in decreased activity of REN protein
CTD PMID:1897344 PMID:2524958 PMID:7013770 PMID:7988622 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with UGT1A1 protein] results in increased glucuronidation of Labetalol CTD PMID:18098064 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol; Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol] CTD PMID:18098064 NCBI chr14:22,597,103...22,619,968 JBrowse link
mianserin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of ADORA1 mRNA CTD PMID:29882086 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of COMT mRNA CTD PMID:29882086 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Fgf4 fibroblast growth factor 4 decreases expression ISO Mianserin results in decreased expression of FGF4 mRNA CTD PMID:24154490 NCBI chr 1:218,024,537...218,029,539
Ensembl chr 1:218,025,810...218,027,220
JBrowse link
G Gsc goosecoid homeobox decreases expression ISO Mianserin results in decreased expression of GSC mRNA CTD PMID:24154490 NCBI chr 6:128,147,181...128,149,220
Ensembl chr 6:128,147,181...128,149,220
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO [Mianserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine; Mianserin binds to and results in decreased activity of HTR2A protein CTD PMID:10764922 PMID:10978843 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases expression
multiple interactions
ISO Mianserin results in increased expression of HTR2C protein
6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [Mianserin results in increased expression of HTR2C protein]; Mianserin binds to and affects the activity of HTR2C protein
[Mianserin binds to and results in decreased activity of HTR2C protein] which results in decreased susceptibility to Methamphetamine; Mianserin binds to and results in decreased activity of HTR2C protein
CTD PMID:10978843 PMID:15213358 PMID:18083778 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects binding
multiple interactions
ISO Mianserin binds to HTR7 protein
[Mianserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Mianserin inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD PMID:14578406 PMID:20827463 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Mianserin results in decreased expression of ID2 mRNA CTD PMID:24154490 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO Mianserin results in decreased expression of PRKCA mRNA CTD PMID:24154490 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Mianserin inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Mianserin inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of SLC6A15 mRNA CTD PMID:29882086 NCBI chr 7:45,328,207...45,381,920
Ensembl chr 7:45,328,105...45,382,229
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO Mianserin results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Mianserin results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
mirtazapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of mirtazapine CTD PMID:14550684 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO mirtazapine inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] CTD PMID:28623179 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Cat catalase multiple interactions EXP mirtazapine inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:19034656 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Drd1 dopamine receptor D1 increases expression EXP mirtazapine results in increased expression of DRD1 mRNA CTD PMID:16499906 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP mirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein] CTD PMID:12523492 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions EXP mirtazapine inhibits the reaction [Quinpirole binds to DRD3 protein] CTD PMID:12523492 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO mirtazapine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions
increases expression
ISO 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [mirtazapine results in increased expression of HTR2C protein]; mirtazapine binds to and affects the activity of HTR2C protein CTD PMID:18083778 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP mirtazapine inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:19034656 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO mirtazapine inhibits the reaction [Thioacetamide results in increased expression of NOX1 protein] CTD PMID:28623179 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Prl prolactin increases expression ISO mirtazapine results in increased expression of PRL protein CTD PMID:15105766 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO mirtazapine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO mirtazapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO mirtazapine results in increased expression of SLC2A4 mRNA CTD PMID:16002093 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc2a5 solute carrier family 2 member 5 increases expression ISO mirtazapine results in increased expression of SLC2A5 mRNA CTD PMID:16002093 NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO mirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form] CTD PMID:28623179 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO mirtazapine results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO mirtazapine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein] CTD PMID:28623179 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
nefazodone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1cf APOBEC1 complementation factor increases expression EXP nefazodone results in increased expression of A1CF mRNA CTD PMID:24136188 NCBI chr 1:250,426,027...250,514,245
Ensembl chr 1:250,426,158...250,514,866
JBrowse link
G Aadac arylacetamide deacetylase decreases expression EXP nefazodone results in decreased expression of AADAC mRNA CTD PMID:24136188 NCBI chr 2:150,146,234...150,157,480
Ensembl chr 2:150,146,234...150,157,480
JBrowse link
G Aadat aminoadipate aminotransferase decreases expression EXP nefazodone results in decreased expression of AADAT mRNA CTD PMID:24136188 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Aamp angio-associated, migratory cell protein increases expression EXP nefazodone results in increased expression of AAMP mRNA CTD PMID:24136188 NCBI chr 9:81,560,836...81,566,642
Ensembl chr 9:81,560,842...81,566,642
JBrowse link
G Aasdhppt aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase increases expression EXP nefazodone results in increased expression of AASDHPPT mRNA CTD PMID:24136188 NCBI chr 8:1,432,757...1,450,175
Ensembl chr 8:1,439,340...1,450,138
JBrowse link
G Abat 4-aminobutyrate aminotransferase decreases expression EXP nefazodone results in decreased expression of ABAT mRNA CTD PMID:24136188 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499
JBrowse link
G Abca3 ATP binding cassette subfamily A member 3 decreases expression EXP nefazodone results in decreased expression of ABCA3 mRNA CTD PMID:24136188 NCBI chr10:13,723,365...13,780,558
Ensembl chr10:13,723,405...13,779,963
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases expression
decreases activity
ISO
EXP
nefazodone inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
nefazodone results in decreased expression of ABCB11 mRNA
nefazodone results in decreased activity of ABCB11 protein
CTD PMID:16410371 PMID:20829430 PMID:22646477 PMID:23956101 PMID:24014644 PMID:24136188 PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression
decreases activity
EXP
ISO
nefazodone results in increased expression of ABCB4 mRNA
nefazodone results in decreased activity of ABCB4 protein
CTD PMID:24136188 PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 increases expression EXP nefazodone results in increased expression of ABCB6 mRNA CTD PMID:24136188 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
decreases expression
multiple interactions
EXP
ISO
nefazodone results in increased expression of ABCC3 mRNA
nefazodone results in decreased expression of ABCC3 mRNA
[nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of ABCC3 mRNA
CTD PMID:24136188 PMID:32152650 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
increases expression
ISO [nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of ABCC4 mRNA
nefazodone results in increased expression of ABCC4 mRNA
CTD PMID:32152650 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 decreases expression EXP nefazodone results in decreased expression of ABCC6 mRNA CTD PMID:24136188 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Abce1 ATP binding cassette subfamily E member 1 increases expression EXP nefazodone results in increased expression of ABCE1 mRNA CTD PMID:24136188 NCBI chr19:31,867,960...31,892,863
Ensembl chr19:31,867,981...31,892,863
JBrowse link
G Abcf3 ATP binding cassette subfamily F member 3 increases expression EXP nefazodone results in increased expression of ABCF3 mRNA CTD PMID:24136188 NCBI chr11:84,026,206...84,037,938
Ensembl chr11:84,026,207...84,037,938
JBrowse link
G Abcg3l2 ATP-binding cassette, subfamily G (WHITE), member 3-like 2 decreases expression EXP nefazodone results in decreased expression of ABCG3L2 mRNA CTD PMID:24136188 NCBI chr14:5,568,023...5,609,333 JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP nefazodone results in increased expression of ABCG5 mRNA CTD PMID:24136188 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP nefazodone results in increased expression of ABCG8 mRNA CTD PMID:24136188 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Abhd1 abhydrolase domain containing 1 decreases expression EXP nefazodone results in decreased expression of ABHD1 mRNA CTD PMID:24136188 NCBI chr 6:26,787,807...26,792,795
Ensembl chr 6:26,784,058...26,792,808
JBrowse link
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase decreases expression EXP nefazodone results in decreased expression of ABHD2 mRNA CTD PMID:24136188 NCBI chr 1:140,998,240...141,087,405
Ensembl chr 1:140,998,240...141,087,405
JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression EXP nefazodone results in increased expression of ABHD4 mRNA CTD PMID:24136188 NCBI chr15:32,888,233...32,906,861
Ensembl chr15:32,894,938...32,906,850
JBrowse link
G Ablim3 actin binding LIM protein family, member 3 increases expression EXP nefazodone results in increased expression of ABLIM3 mRNA CTD PMID:24136188 NCBI chr18:57,126,534...57,245,965
Ensembl chr18:57,128,399...57,245,666
JBrowse link
G Abtb1 ankyrin repeat and BTB domain containing 1 increases expression EXP nefazodone results in increased expression of ABTB1 mRNA CTD PMID:24136188 NCBI chr 4:120,778,580...120,784,807
Ensembl chr 4:120,778,580...120,784,807
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases expression EXP nefazodone results in increased expression of ACAA1 mRNA CTD PMID:24136188 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 increases expression EXP nefazodone results in increased expression of ACAA2 mRNA CTD PMID:24136188 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression EXP nefazodone results in decreased expression of ACACA mRNA CTD PMID:24136188 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acad11 acyl-CoA dehydrogenase family, member 11 increases expression EXP nefazodone results in increased expression of ACAD11 mRNA CTD PMID:24136188 NCBI chr 8:112,594,758...112,676,275
Ensembl chr 8:112,594,691...112,676,280
JBrowse link
G Acly ATP citrate lyase decreases expression EXP nefazodone results in decreased expression of ACLY mRNA CTD PMID:24136188 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Aco1 aconitase 1 increases expression EXP nefazodone results in increased expression of ACO1 mRNA CTD PMID:24136188 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Aco2 aconitase 2 increases expression EXP nefazodone results in increased expression of ACO2 mRNA CTD PMID:24136188 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Acot12 acyl-CoA thioesterase 12 increases expression EXP nefazodone results in increased expression of ACOT12 mRNA CTD PMID:24136188 NCBI chr 2:20,857,056...20,901,656
Ensembl chr 2:20,857,202...20,901,659
JBrowse link
G Acot13 acyl-CoA thioesterase 13 decreases expression EXP nefazodone results in decreased expression of ACOT13 mRNA CTD PMID:24136188 NCBI chr17:42,241,141...42,253,611
Ensembl chr17:42,241,159...42,253,649
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP nefazodone results in increased expression of ACOT2 mRNA CTD PMID:24136188 NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487
JBrowse link
G Acot7 acyl-CoA thioesterase 7 increases expression EXP nefazodone results in increased expression of ACOT7 mRNA CTD PMID:24136188 NCBI chr 5:169,357,582...169,450,215
Ensembl chr 5:169,357,517...169,450,219
JBrowse link
G Acot8 acyl-CoA thioesterase 8 increases expression EXP nefazodone results in increased expression of ACOT8 mRNA CTD PMID:24136188 NCBI chr 3:161,260,837...161,272,495
Ensembl chr 3:161,259,735...161,272,460
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP nefazodone results in increased expression of ACOX1 mRNA CTD PMID:24136188 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acox3 acyl-CoA oxidase 3, pristanoyl decreases expression EXP nefazodone results in decreased expression of ACOX3 mRNA CTD PMID:24136188 NCBI chr14:80,313,202...80,358,115
Ensembl chr14:80,314,431...80,355,420
JBrowse link
G Acp1 acid phosphatase 1 increases expression EXP nefazodone results in increased expression of ACP1 mRNA CTD PMID:24136188 NCBI chr 6:49,836,064...49,851,714
Ensembl chr 6:49,836,075...49,851,714
JBrowse link
G Acp2 acid phosphatase 2, lysosomal decreases expression EXP nefazodone results in decreased expression of ACP2 mRNA CTD PMID:24136188 NCBI chr 3:80,020,346...80,030,365
Ensembl chr 3:80,021,440...80,030,363
JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 decreases expression EXP nefazodone results in decreased expression of ACSF2 mRNA CTD PMID:24136188 NCBI chr10:82,284,719...82,326,771
Ensembl chr10:82,284,720...82,326,771
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression EXP nefazodone results in decreased expression of ACSL1 mRNA CTD PMID:24136188 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 increases expression EXP nefazodone results in increased expression of ACSL4 mRNA CTD PMID:24136188 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 decreases expression EXP nefazodone results in decreased expression of ACSL5 mRNA CTD PMID:24136188 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008
JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 increases expression EXP nefazodone results in increased expression of ACSM2A mRNA CTD PMID:24136188 NCBI chr 1:189,289,957...189,329,007
Ensembl chr 1:189,289,957...189,395,276
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 decreases expression EXP nefazodone results in decreased expression of ACSS2 mRNA CTD PMID:24136188 NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856
JBrowse link
G Actr3 actin related protein 3 increases expression EXP nefazodone results in increased expression of ACTR3 mRNA CTD PMID:24136188 NCBI chr13:41,695,520...41,738,622
Ensembl chr13:41,695,183...41,738,658
JBrowse link
G Adamts7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 decreases expression EXP nefazodone results in decreased expression of ADAMTS7 mRNA CTD PMID:24136188 NCBI chr 8:97,535,777...97,575,661
Ensembl chr 8:97,535,777...97,575,655
JBrowse link
G Adap2 ArfGAP with dual PH domains 2 decreases expression EXP nefazodone results in decreased expression of ADAP2 mRNA CTD PMID:24136188 NCBI chr10:67,494,851...67,527,582
Ensembl chr10:67,494,984...67,526,426
JBrowse link
G Adck5 aarF domain containing kinase 5 increases expression EXP nefazodone results in increased expression of ADCK5 mRNA CTD PMID:24136188 NCBI chr 7:117,643,976...117,661,789
Ensembl chr 7:117,643,206...117,661,845
JBrowse link
G Add1 adducin 1 increases expression EXP nefazodone results in increased expression of ADD1 mRNA CTD PMID:24136188 NCBI chr14:81,367,466...81,426,610
Ensembl chr14:81,367,468...81,426,496
JBrowse link
G Adgrl2 adhesion G protein-coupled receptor L2 decreases expression EXP nefazodone results in decreased expression of ADGRL2 mRNA CTD PMID:24136188 NCBI chr 2:258,792,838...258,997,145
Ensembl chr 2:258,792,839...258,997,145
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide increases expression EXP nefazodone results in increased expression of ADH4 mRNA CTD PMID:24136188 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 decreases expression EXP nefazodone results in decreased expression of ADHFE1 mRNA CTD PMID:24136188 NCBI chr 5:9,403,194...9,429,783
Ensembl chr 5:9,403,196...9,429,859
JBrowse link
G Adprm ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent increases expression EXP nefazodone results in increased expression of ADPRM mRNA CTD PMID:24136188 NCBI chr10:53,583,275...53,595,821
Ensembl chr10:53,583,276...53,595,827
JBrowse link
G Adprs ADP-ribosylserine hydrolase increases expression EXP nefazodone results in increased expression of ADPRS mRNA CTD PMID:24136188 NCBI chr 5:144,336,312...144,341,586
Ensembl chr 5:144,336,312...144,341,586
JBrowse link
G Adra1b adrenoceptor alpha 1B decreases expression EXP nefazodone results in decreased expression of ADRA1B mRNA CTD PMID:24136188 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adrm1 adhesion regulating molecule 1 increases expression EXP nefazodone results in increased expression of ADRM1 mRNA CTD PMID:24136188 NCBI chr 3:175,548,181...175,552,943
Ensembl chr 3:175,548,174...175,552,947
JBrowse link
G Adsl adenylosuccinate lyase increases expression EXP nefazodone results in increased expression of ADSL mRNA CTD PMID:24136188 NCBI chr 7:122,157,201...122,192,328
Ensembl chr 7:122,157,201...122,192,328
JBrowse link
G Afg3l2 AFG3 like matrix AAA peptidase subunit 2 increases expression EXP nefazodone results in increased expression of AFG3L2 mRNA CTD PMID:24136188 NCBI chr18:63,141,418...63,185,510
Ensembl chr18:63,141,418...63,185,510
JBrowse link
G Afm afamin decreases expression EXP nefazodone results in decreased expression of AFM mRNA CTD PMID:24136188 NCBI chr14:19,078,678...19,132,212
Ensembl chr14:19,078,680...19,132,208
JBrowse link
G Agxt2 alanine-glyoxylate aminotransferase 2 decreases expression EXP nefazodone results in decreased expression of AGXT2 mRNA CTD PMID:24136188 NCBI chr 2:60,337,667...60,379,144
Ensembl chr 2:60,337,667...60,379,420
JBrowse link
G Ahcyl1 adenosylhomocysteinase-like 1 increases expression EXP nefazodone results in increased expression of AHCYL1 mRNA CTD PMID:24136188 NCBI chr 2:210,438,884...210,474,350
Ensembl chr 2:210,438,893...210,473,761
JBrowse link
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression EXP nefazodone results in increased expression of AHSA1 mRNA CTD PMID:24136188 NCBI chr 6:111,296,168...111,304,224
Ensembl chr 6:111,296,417...111,304,224
JBrowse link
G Aig1 androgen-induced 1 increases expression EXP nefazodone results in increased expression of AIG1 mRNA CTD PMID:24136188 NCBI chr 1:7,816,841...8,038,805
Ensembl chr 1:7,816,838...8,038,665
JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 increases expression EXP nefazodone results in increased expression of AIMP1 mRNA CTD PMID:24136188 NCBI chr 2:237,727,782...237,751,327
Ensembl chr 2:237,727,764...237,751,378
JBrowse link
G Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 increases expression EXP nefazodone results in increased expression of AIMP2 mRNA CTD PMID:24136188 NCBI chr12:12,738,784...12,748,345
Ensembl chr12:12,738,812...12,748,345
JBrowse link
G Aip aryl-hydrocarbon receptor-interacting protein increases expression EXP nefazodone results in increased expression of AIP mRNA CTD PMID:24136188 NCBI chr 1:219,361,859...219,373,924
Ensembl chr 1:219,361,860...219,374,014
JBrowse link
G Ak3 adenylate kinase 3 increases expression EXP nefazodone results in increased expression of AK3 mRNA CTD PMID:24136188 NCBI chr 1:247,144,486...247,169,690
Ensembl chr 1:247,144,491...247,169,693
JBrowse link
G Ak4 adenylate kinase 4 decreases expression EXP nefazodone results in decreased expression of AK4 mRNA CTD PMID:24136188 NCBI chr 5:120,250,318...120,309,153
Ensembl chr 5:120,250,616...120,305,897
JBrowse link
G Akap8l A-kinase anchoring protein 8 like decreases expression EXP nefazodone results in decreased expression of AKAP8L mRNA CTD PMID:24136188 NCBI chr 7:14,340,168...14,369,835
Ensembl chr 7:14,340,170...14,369,821
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases expression EXP nefazodone results in increased expression of AKR1A1 mRNA CTD PMID:24136188 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases expression EXP nefazodone results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 increases expression EXP nefazodone results in increased expression of AKR1D1 mRNA CTD PMID:24136188 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 increases expression EXP nefazodone results in increased expression of AKR7A2 mRNA CTD PMID:24136188 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression
multiple interactions
decreases expression
EXP
ISO
nefazodone results in increased expression of AKR7A3 mRNA
[nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of AKR7A3 mRNA
nefazodone results in decreased expression of AKR7A3 mRNA
CTD PMID:24136188 PMID:32152650 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Akt1s1 AKT1 substrate 1 increases expression EXP nefazodone results in increased expression of AKT1S1 mRNA CTD PMID:24136188 NCBI chr 1:100,845,443...100,851,961
Ensembl chr 1:100,845,563...100,851,960
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression EXP nefazodone results in increased expression of ALAS1 mRNA CTD PMID:24136188 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP nefazodone results in increased expression of ALDH1A1 mRNA CTD PMID:24136188 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression EXP nefazodone results in decreased expression of ALDH1B1 mRNA CTD PMID:24136188 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358
JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 increases expression EXP nefazodone results in increased expression of ALDH1L1 mRNA CTD PMID:24136188 NCBI chr 4:123,516,553...123,564,067
Ensembl chr 4:123,516,788...123,557,501
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression EXP nefazodone results in increased expression of ALDH3A2 mRNA CTD PMID:24136188 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP nefazodone results in increased expression of ALDOA mRNA CTD PMID:24136188 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Alg12 ALG12, alpha-1,6-mannosyltransferase increases expression EXP nefazodone results in increased expression of ALG12 mRNA CTD PMID:24136188 NCBI chr 7:129,798,663...129,812,677
Ensembl chr 7:129,798,663...129,812,388
JBrowse link
G Alg3 ALG3, alpha-1,3- mannosyltransferase increases expression EXP nefazodone results in increased expression of ALG3 mRNA CTD PMID:24136188 NCBI chr11:83,985,484...83,991,706
Ensembl chr11:83,986,230...83,991,706
JBrowse link
G Alkbh7 alkB homolog 7 increases expression EXP nefazodone results in increased expression of ALKBH7 mRNA CTD PMID:24136188 NCBI chr 9:10,045,375...10,047,507
Ensembl chr 9:10,045,375...10,047,507
JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 increases expression EXP nefazodone results in increased expression of AMD1 mRNA CTD PMID:24136188 NCBI chr20:45,384,000...45,399,694
Ensembl chr20:45,384,000...45,399,694
JBrowse link
G Ammecr1l AMMECR1 like decreases expression EXP nefazodone results in decreased expression of AMMECR1L mRNA CTD PMID:24136188 NCBI chr18:24,539,530...24,563,576
Ensembl chr18:24,540,659...24,563,576
JBrowse link
G Amt aminomethyltransferase increases expression EXP nefazodone results in increased expression of AMT mRNA CTD PMID:24136188 NCBI chr 8:117,068,388...117,078,633
Ensembl chr 8:117,068,582...117,077,913
JBrowse link
G Amy1a amylase, alpha 1A decreases expression EXP nefazodone results in decreased expression of AMY1A mRNA CTD PMID:24136188 NCBI chr 2:216,428,709...216,443,518
Ensembl chr 2:216,428,709...216,443,518
JBrowse link
G Ang angiogenin decreases expression EXP nefazodone results in decreased expression of ANG mRNA CTD PMID:24136188 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression EXP nefazodone results in decreased expression of ANGPTL3 mRNA CTD PMID:24136188 NCBI chr 5:117,698,590...117,706,729
Ensembl chr 5:117,698,764...117,705,808
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP nefazodone results in decreased expression of ANGPTL4 mRNA CTD PMID:24136188 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Ankh ANKH inorganic pyrophosphate transport regulator decreases expression EXP nefazodone results in decreased expression of ANKH mRNA CTD PMID:24136188 NCBI chr 2:80,131,563...80,256,948
Ensembl chr 2:80,131,563...80,256,954
JBrowse link
G Ankrd13c ankyrin repeat domain 13C decreases expression EXP nefazodone results in decreased expression of ANKRD13C mRNA CTD PMID:24136188 NCBI chr 2:264,785,379...264,833,283
Ensembl chr 2:264,786,242...264,833,283
JBrowse link
G Anks4b ankyrin repeat and sterile alpha motif domain containing 4B decreases expression EXP nefazodone results in decreased expression of ANKS4B mRNA CTD PMID:24136188 NCBI chr 1:189,940,305...189,942,113
Ensembl chr 1:189,940,291...189,942,112
JBrowse link
G Ano10 anoctamin 10 increases expression EXP nefazodone results in increased expression of ANO10 mRNA CTD PMID:24136188 NCBI chr 8:130,812,941...130,931,021
Ensembl chr 8:130,813,214...130,930,990
JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A decreases expression EXP nefazodone results in decreased expression of ANP32A mRNA CTD PMID:24136188 NCBI chr 8:67,295,578...67,333,075
Ensembl chr 8:67,295,727...67,333,247
JBrowse link
G Anp32b acidic nuclear phosphoprotein 32 family member B increases expression EXP nefazodone results in increased expression of ANP32B mRNA CTD PMID:24136188 NCBI chr 5:62,070,709...62,094,633
Ensembl chr 5:62,071,346...62,094,633
JBrowse link
G Anp32e acidic nuclear phosphoprotein 32 family member E increases expression EXP nefazodone results in increased expression of ANP32E mRNA CTD PMID:24136188 NCBI chr 2:198,040,573...198,057,005
Ensembl chr 2:198,040,536...198,057,003
JBrowse link
G Anpep alanyl aminopeptidase, membrane decreases expression EXP nefazodone results in decreased expression of ANPEP mRNA CTD PMID:24136188 NCBI chr 1:141,561,364...141,604,249
Ensembl chr 1:141,561,334...141,604,273
JBrowse link
G Antxr2 ANTXR cell adhesion molecule 2 decreases expression EXP nefazodone results in decreased expression of ANTXR2 mRNA CTD PMID:24136188 NCBI chr14:13,191,716...13,331,286
Ensembl chr14:13,192,347...13,274,978
JBrowse link
G Anxa3 annexin A3 decreases expression EXP nefazodone results in decreased expression of ANXA3 mRNA CTD PMID:24136188 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Anxa5 annexin A5 decreases expression EXP nefazodone results in decreased expression of ANXA5 mRNA CTD PMID:24136188 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Anxa7 annexin A7 increases expression EXP nefazodone results in increased expression of ANXA7 mRNA CTD PMID:24136188 NCBI chr15:4,254,470...4,281,296
Ensembl chr15:4,254,499...4,281,287
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression
multiple interactions
decreases expression
EXP
ISO
nefazodone results in increased expression of AOX1 mRNA
[nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of AOX1 mRNA
nefazodone results in decreased expression of AOX1 mRNA
CTD PMID:24136188 PMID:32152650 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Ap1m1 adaptor related protein complex 1 subunit mu 1 increases expression EXP nefazodone results in increased expression of AP1M1 mRNA CTD PMID:24136188 NCBI chr16:19,288,354...19,303,818
Ensembl chr16:19,288,355...19,303,824
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 increases expression EXP nefazodone results in increased expression of AP2M1 mRNA CTD PMID:24136188 NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP nefazodone results in increased expression of APEX1 mRNA CTD PMID:24136188 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Api5 apoptosis inhibitor 5 increases expression EXP nefazodone results in increased expression of API5 mRNA CTD PMID:24136188 NCBI chr 3:83,310,878...83,336,053
Ensembl chr 3:83,310,884...83,335,960
JBrowse link
G Aplp2 amyloid beta precursor like protein 2 decreases expression EXP nefazodone results in decreased expression of APLP2 mRNA CTD PMID:24136188 NCBI chr 8:32,298,526...32,328,821
Ensembl chr 8:32,298,532...32,328,839
JBrowse link
G Apmap adipocyte plasma membrane associated protein decreases expression EXP nefazodone results in decreased expression of APMAP mRNA CTD PMID:24136188 NCBI chr 3:146,376,828...146,407,259
Ensembl chr 3:146,376,828...146,407,252
JBrowse link
G Apoa4 apolipoprotein A4 decreases expression EXP nefazodone results in decreased expression of APOA4 mRNA CTD PMID:24136188 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Apoa5 apolipoprotein A5 decreases expression EXP nefazodone results in decreased expression of APOA5 mRNA CTD PMID:24136188 NCBI chr 8:50,559,079...50,561,720
Ensembl chr 8:50,559,126...50,561,736
JBrowse link
G Apol3 apolipoprotein L, 3 decreases expression EXP nefazodone results in decreased expression of APOL3 mRNA CTD PMID:24136188 NCBI chr 7:118,685,022...118,694,016
Ensembl chr 7:118,685,022...118,694,015
JBrowse link
G Apom apolipoprotein M decreases expression EXP nefazodone results in decreased expression of APOM mRNA CTD PMID:24136188 NCBI chr20:5,120,473...5,123,073
Ensembl chr20:5,120,474...5,123,073
JBrowse link
G Aqp8 aquaporin 8 increases expression EXP nefazodone results in increased expression of AQP8 mRNA CTD PMID:24136188 NCBI chr 1:193,424,818...193,430,665
Ensembl chr 1:193,424,812...193,430,676
JBrowse link
G Arcn1 archain 1 increases expression EXP nefazodone results in increased expression of ARCN1 mRNA CTD PMID:24136188 NCBI chr 8:49,051,257...49,075,861
Ensembl chr 8:49,051,246...49,075,892
JBrowse link
G Arf1 ADP-ribosylation factor 1 increases expression EXP nefazodone results in increased expression of ARF1 mRNA CTD PMID:24136188 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Arf6 ADP-ribosylation factor 6 increases expression EXP nefazodone results in increased expression of ARF6 mRNA CTD PMID:24136188 NCBI chr 6:91,697,109...91,698,257
Ensembl chr 6:91,697,109...91,698,255
JBrowse link
G Arfip2 ADP-ribosylation factor interacting protein 2 decreases expression EXP nefazodone results in decreased expression of ARFIP2 mRNA CTD PMID:24136188 NCBI chr 1:170,464,995...170,471,138
Ensembl chr 1:170,466,395...170,471,076
JBrowse link
G Arg1 arginase 1 increases expression EXP nefazodone results in increased expression of ARG1 mRNA CTD PMID:24136188 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arhgef19 Rho guanine nucleotide exchange factor 19 decreases expression EXP nefazodone results in decreased expression of ARHGEF19 mRNA CTD PMID:24136188 NCBI chr 5:159,754,954...159,773,699
Ensembl chr 5:159,755,535...159,773,699
JBrowse link
G Arid1a AT-rich interaction domain 1A decreases expression EXP nefazodone results in decreased expression of ARID1A mRNA CTD PMID:24136188 NCBI chr 5:151,904,687...151,977,973
Ensembl chr 5:151,904,684...151,977,636
JBrowse link
G Arl4a ADP-ribosylation factor like GTPase 4A increases expression EXP nefazodone results in increased expression of ARL4A mRNA CTD PMID:24136188 NCBI chr 6:59,945,926...59,950,586
Ensembl chr 6:59,948,577...59,950,586
JBrowse link
G Arl5a ADP-ribosylation factor like GTPase 5A increases expression EXP nefazodone results in increased expression of ARL5A mRNA CTD PMID:24136188 NCBI chr 3:37,922,544...37,947,434
Ensembl chr 3:37,924,793...37,947,283
JBrowse link
G Arl6ip1 ADP-ribosylation factor like GTPase 6 interacting protein 1 decreases expression EXP nefazodone results in decreased expression of ARL6IP1 mRNA CTD PMID:24136188 NCBI chr 1:187,770,160...187,779,675
Ensembl chr 1:187,770,160...187,779,675
JBrowse link
G Arl6ip4 ADP-ribosylation factor like GTPase 6 interacting protein 4 increases expression EXP nefazodone results in increased expression of ARL6IP4 mRNA CTD PMID:24136188 NCBI chr12:37,904,376...37,906,521
Ensembl chr12:37,904,379...37,906,521
JBrowse link
G Arpc5l actin related protein 2/3 complex, subunit 5-like increases expression EXP nefazodone results in increased expression of ARPC5L mRNA CTD PMID:24136188 NCBI chr 3:23,301,455...23,309,077
Ensembl chr 3:23,301,455...23,309,072
JBrowse link
G Arpin actin-related protein 2/3 complex inhibitor increases expression EXP nefazodone results in increased expression of ARPIN mRNA CTD PMID:24136188 NCBI chr 1:141,664,790...141,672,789
Ensembl chr 1:141,662,850...141,672,810
JBrowse link
G Arpp19 cAMP-regulated phosphoprotein 19 increases expression EXP nefazodone results in increased expression of ARPP19 mRNA CTD PMID:24136188 NCBI chr 8:81,949,577...81,972,054
Ensembl chr 8:81,949,877...81,968,589
JBrowse link
G Arsa arylsulfatase A decreases expression EXP nefazodone results in decreased expression of ARSA mRNA CTD PMID:24136188 NCBI chr 7:130,446,644...130,452,632
Ensembl chr 7:130,446,668...130,451,283
JBrowse link
G Asap2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 decreases expression EXP nefazodone results in decreased expression of ASAP2 mRNA CTD PMID:24136188 NCBI chr 6:43,231,178...43,348,606
Ensembl chr 6:43,234,526...43,343,551
JBrowse link
G Asf1a anti-silencing function 1A histone chaperone increases expression EXP nefazodone results in increased expression of ASF1A mRNA CTD PMID:24136188 NCBI chr20:34,894,419...34,909,265
Ensembl chr20:34,894,419...34,909,265
JBrowse link
G Ash1l ASH1 like histone lysine methyltransferase decreases expression EXP nefazodone results in decreased expression of ASH1L mRNA CTD PMID:24136188 NCBI chr 2:188,252,592...188,389,251
Ensembl chr 2:188,253,220...188,389,250
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression EXP nefazodone results in increased expression of ASNS mRNA CTD PMID:24136188 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Asnsd1 asparagine synthetase domain containing 1 increases expression EXP nefazodone results in increased expression of ASNSD1 mRNA CTD PMID:24136188 NCBI chr 9:52,988,042...53,009,054
Ensembl chr 9:53,004,499...53,009,054
JBrowse link
G Aspg asparaginase decreases expression EXP nefazodone results in decreased expression of ASPG mRNA CTD PMID:24136188 NCBI chr 6:136,682,279...136,701,673
Ensembl chr 6:136,682,126...136,701,628
JBrowse link
G Atf1 activating transcription factor 1 increases expression EXP nefazodone results in increased expression of ATF1 mRNA CTD PMID:24136188 NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [nefazodone results in increased expression of ATF4 protein]; [nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of ATF4 mRNA
nefazodone results in increased expression of ATF4 mRNA; nefazodone results in increased expression of ATF4 protein
CTD PMID:27613715 PMID:32152650 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf5 activating transcription factor 5 increases expression EXP nefazodone results in increased expression of ATF5 mRNA CTD PMID:24136188 NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522
JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions
ISO nefazodone results in increased expression of ATF6 mRNA
[nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of ATF6 mRNA
CTD PMID:32152650 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression
ISO [nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of ATG7 mRNA
nefazodone results in increased expression of ATG7 mRNA
CTD PMID:32152650 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atg9a autophagy related 9A decreases expression EXP nefazodone results in decreased expression of ATG9A mRNA CTD PMID:24136188 NCBI chr 9:82,382,800...82,393,429
Ensembl chr 9:82,382,800...82,393,382
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase increases expression EXP nefazodone results in increased expression of ATIC mRNA CTD PMID:24136188 NCBI chr 9:78,862,013...78,882,061
Ensembl chr 9:78,862,013...78,882,060
JBrowse link
G Atl2 atlastin GTPase 2 increases expression EXP nefazodone results in increased expression of ATL2 mRNA CTD PMID:24136188 NCBI chr 6:2,568,975...2,610,432
Ensembl chr 6:2,568,990...2,610,437
JBrowse link
G Atl3 atlastin GTPase 3 increases expression EXP nefazodone results in increased expression of ATL3 mRNA CTD PMID:24136188 NCBI chr 1:222,746,023...222,788,439
Ensembl chr 1:222,746,023...222,786,942
JBrowse link
G Atoh8 atonal bHLH transcription factor 8 decreases expression EXP nefazodone results in decreased expression of ATOH8 mRNA CTD PMID:24136188 NCBI chr 4:100,067,341...100,099,517
Ensembl chr 4:100,067,341...100,099,517
JBrowse link
G Atp11a ATPase phospholipid transporting 11A decreases expression EXP nefazodone results in decreased expression of ATP11A mRNA CTD PMID:24136188 NCBI chr16:81,990,340...82,100,222
Ensembl chr16:81,990,340...82,100,222
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta increases expression EXP nefazodone results in increased expression of ATP5F1D mRNA CTD PMID:24136188 NCBI chr 7:12,426,807...12,432,120
Ensembl chr 7:12,426,809...12,432,130
JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 increases expression EXP nefazodone results in increased expression of ATPIF1 mRNA CTD PMID:24136188 NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321
JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 increases expression EXP nefazodone results in increased expression of ATP5MC1 mRNA CTD PMID:24136188 NCBI chr10:83,895,941...83,898,640
Ensembl chr10:83,895,947...83,898,527
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d increases expression EXP nefazodone results in increased expression of ATP5H mRNA CTD PMID:24136188 NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668
JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 increases expression EXP nefazodone results in increased expression of ATP6AP2 mRNA CTD PMID:24136188 NCBI chr  X:11,137,889...11,164,854
Ensembl chr  X:11,136,939...11,164,915
JBrowse link
G Atp6v0b ATPase H+ transporting V0 subunit B increases expression EXP nefazodone results in increased expression of ATP6V0B mRNA CTD PMID:24136188 NCBI chr 5:136,718,352...136,719,868
Ensembl chr 5:136,718,352...136,721,379
JBrowse link
G Atp6v0e1 ATPase H+ transporting V0 subunit e1 increases expression EXP nefazodone results in increased expression of ATP6V0E1 mRNA CTD PMID:24136188 NCBI chr10:16,769,857...16,792,930
Ensembl chr10:16,769,666...16,792,909
JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A increases expression EXP nefazodone results in increased expression of ATP6V1A mRNA CTD PMID:24136188 NCBI chr11:61,531,386...61,584,634
Ensembl chr11:61,531,416...61,584,634
JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 increases expression EXP nefazodone results in increased expression of ATP6V1B2 mRNA CTD PMID:24136188 NCBI chr16:22,326,537...22,350,143
Ensembl chr16:22,326,529...22,350,155
JBrowse link
G Atp6v1c1 ATPase H+ transporting V1 subunit C1 increases expression EXP nefazodone results in increased expression of ATP6V1C1 mRNA CTD PMID:24136188 NCBI chr 7:77,678,853...77,716,658
Ensembl chr 7:77,678,968...77,716,408
JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D increases expression EXP nefazodone results in increased expression of ATP6V1D mRNA CTD PMID:24136188 NCBI chr 6:102,032,271...102,047,754
Ensembl chr 6:102,032,276...102,047,758
JBrowse link
G Atp6v1e1 ATPase H+ transporting V1 subunit E1 increases expression EXP nefazodone results in increased expression of ATP6V1E1 mRNA CTD PMID:24136188 NCBI chr 4:153,351,434...153,373,558
Ensembl chr 4:153,351,421...153,373,649
JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F increases expression EXP nefazodone results in increased expression of ATP6V1F mRNA CTD PMID:24136188 NCBI chr 4:56,744,563...56,747,657
Ensembl chr 4:56,744,561...56,747,656
JBrowse link
G Atp6v1g1 ATPase H+ transporting V1 subunit G1 increases expression EXP nefazodone results in increased expression of ATP6V1G1 mRNA CTD PMID:24136188 NCBI chr 5:79,367,663...79,373,843
Ensembl chr 5:79,367,663...79,373,843
JBrowse link
G Atp6v1h ATPase H+ transporting V1 subunit H increases expression EXP nefazodone results in increased expression of ATP6V1H mRNA CTD PMID:24136188 NCBI chr 5:14,262,352...14,367,898
Ensembl chr 5:14,262,349...14,367,898
JBrowse link
G Atpsckmt ATP synthase c subunit lysine N-methyltransferase increases expression EXP nefazodone results in increased expression of ATPSCKMT mRNA CTD PMID:24136188 NCBI chr 2:84,678,892...84,694,152
Ensembl chr 2:84,678,948...84,693,988
JBrowse link
G Atr ATR serine/threonine kinase decreases expression ISO nefazodone results in decreased expression of ATR mRNA CTD PMID:27288927 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Atrn attractin decreases expression EXP nefazodone results in decreased expression of ATRN mRNA CTD PMID:24136188 NCBI chr 3:123,434,409...123,567,922
Ensembl chr 3:123,434,409...123,567,918
JBrowse link
G Auh AU RNA binding methylglutaconyl-CoA hydratase increases expression EXP nefazodone results in increased expression of AUH mRNA CTD PMID:24136188 NCBI chr17:12,310,178...12,405,224
Ensembl chr17:12,310,214...12,405,205
JBrowse link
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor increases expression EXP nefazodone results in increased expression of AUP1 mRNA CTD PMID:24136188 NCBI chr 4:113,887,030...113,890,103
Ensembl chr 4:113,887,115...113,890,101
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression EXP nefazodone results in decreased expression of AVPR1A mRNA CTD PMID:24136188 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
JBrowse link
G Azi2 5-azacytidine induced 2 increases expression EXP nefazodone results in increased expression of AZI2 mRNA CTD PMID:24136188 NCBI chr 8:126,411,030...126,435,581
Ensembl chr 8:126,411,829...126,434,579
JBrowse link
G Azin1 antizyme inhibitor 1 increases expression EXP nefazodone results in increased expression of AZIN1 mRNA CTD PMID:24136188 NCBI chr 7:77,345,646...77,372,398
Ensembl chr 7:77,345,646...77,372,398
JBrowse link
G B2m beta-2 microglobulin decreases expression EXP nefazodone results in decreased expression of B2M mRNA CTD PMID:24136188 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Bag3 BAG cochaperone 3 increases expression EXP nefazodone results in increased expression of BAG3 mRNA CTD PMID:24136188 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Baiap2l1 BAR/IMD domain containing adaptor protein 2 like 1 increases expression EXP nefazodone results in increased expression of BAIAP2L1 mRNA CTD PMID:24136188 NCBI chr12:12,226,967...12,321,172
Ensembl chr12:12,227,010...12,321,172
JBrowse link
G Banf1 BAF nuclear assembly factor 1 increases expression EXP nefazodone results in increased expression of BANF1 mRNA CTD PMID:24136188 NCBI chr 1:220,744,195...220,746,224
Ensembl chr 1:220,744,195...220,746,224
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO nefazodone results in increased expression of BBC3 mRNA CTD PMID:27288927 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 decreases expression EXP nefazodone results in decreased expression of BBOX1 mRNA CTD PMID:24136188 NCBI chr 3:101,425,684...101,474,848
Ensembl chr 3:101,427,055...101,474,890
JBrowse link
G Bcap29 B-cell receptor-associated protein 29 increases expression EXP nefazodone results in increased expression of BCAP29 mRNA CTD PMID:24136188 NCBI chr 6:50,883,758...50,923,743
Ensembl chr 6:50,883,787...50,923,510
JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase decreases expression EXP nefazodone results in decreased expression of BCKDK mRNA CTD PMID:24136188 NCBI chr 1:199,351,628...199,356,299
Ensembl chr 1:199,351,628...199,356,881
JBrowse link
G Bcl6 BCL6, transcription repressor increases expression EXP nefazodone results in increased expression of BCL6 mRNA CTD PMID:24136188 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bcs1l BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone increases expression EXP nefazodone results in increased expression of BCS1L mRNA CTD PMID:24136188 NCBI chr 9:81,868,158...81,872,201
Ensembl chr 9:81,868,265...81,872,197
JBrowse link
G Bet1 Bet1 golgi vesicular membrane trafficking protein increases expression EXP nefazodone results in increased expression of BET1 mRNA CTD PMID:24136188 NCBI chr 4:29,082,368...29,092,638
Ensembl chr 4:29,082,365...29,092,753
JBrowse link
G Bgn biglycan decreases expression EXP nefazodone results in decreased expression of BGN mRNA CTD PMID:24136188 NCBI chr  X:157,319,042...157,331,204
Ensembl chr  X:157,319,046...157,331,204
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase decreases expression EXP nefazodone results in decreased expression of BHMT mRNA CTD PMID:24136188 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G Blvrb biliverdin reductase B increases expression EXP nefazodone results in increased expression of BLVRB mRNA CTD PMID:24136188 NCBI chr 1:84,256,063...84,273,726
Ensembl chr 1:84,256,159...84,274,075
JBrowse link
G Bmp1 bone morphogenetic protein 1 decreases expression EXP nefazodone results in decreased expression of BMP1 mRNA CTD PMID:24136188 NCBI chr15:52,166,401...52,210,786
Ensembl chr15:52,166,401...52,210,746
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP nefazodone results in increased expression of BNIP3 mRNA CTD PMID:24136188 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression EXP nefazodone results in increased expression of BNIP3L mRNA CTD PMID:24136188 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Bola3 bolA family member 3 increases expression EXP nefazodone results in increased expression of BOLA3 mRNA CTD PMID:24136188 NCBI chr 4:115,046,693...115,056,140
Ensembl chr 4:115,046,693...115,056,140
JBrowse link
G Bop1 BOP1 ribosomal biogenesis factor increases expression EXP nefazodone results in increased expression of BOP1 mRNA CTD PMID:24136188 NCBI chr 7:117,514,529...117,538,342
Ensembl chr 7:117,514,533...117,538,342
JBrowse link
G Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 increases expression EXP nefazodone results in increased expression of BPNT1 mRNA CTD PMID:24136188 NCBI chr13:103,268,045...103,292,848
Ensembl chr13:103,268,068...103,292,854
JBrowse link
G Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 increases expression EXP nefazodone results in increased expression of BPNT2 mRNA CTD PMID:24136188 NCBI chr17:90,191,119...90,218,013
Ensembl chr17:90,188,043...90,218,013
Ensembl chr 5:90,188,043...90,218,013
JBrowse link
G Brd3 bromodomain containing 3 decreases expression EXP nefazodone results in decreased expression of BRD3 mRNA CTD PMID:24136188 NCBI chr 3:5,995,204...6,054,467
Ensembl chr 3:5,997,315...6,054,483
JBrowse link
G Brix1 biogenesis of ribosomes BRX1 increases expression EXP nefazodone results in increased expression of BRIX1 mRNA CTD PMID:24136188 NCBI chr 2:60,450,547...60,461,425
Ensembl chr 2:60,450,374...60,461,458
JBrowse link
G Brk1 BRICK1 subunit of SCAR/WAVE actin nucleating complex increases expression EXP nefazodone results in increased expression of BRK1 mRNA CTD PMID:24136188 NCBI chr 4:145,559,206...145,574,438
Ensembl chr 4:145,559,206...145,574,438
JBrowse link
G Btbd1 BTB domain containing 1 decreases expression EXP nefazodone results in decreased expression of BTBD1 mRNA CTD PMID:24136188 NCBI chr 1:143,609,729...143,647,124
Ensembl chr 1:143,609,731...143,647,124
JBrowse link
G Btf3 basic transcription factor 3 increases expression EXP nefazodone results in increased expression of BTF3 mRNA CTD PMID:24136188 NCBI chr 2:28,417,316...28,424,436
Ensembl chr 2:28,417,579...28,423,762
JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression EXP nefazodone results in decreased expression of BTG1 mRNA CTD PMID:24136188 NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088
JBrowse link
G Bub3 BUB3 mitotic checkpoint protein increases expression EXP nefazodone results in increased expression of BUB3 mRNA CTD PMID:24136188 NCBI chr 1:203,526,853...203,537,459
Ensembl chr 1:203,524,426...203,557,337
JBrowse link
G Bysl bystin-like increases expression EXP nefazodone results in increased expression of BYSL mRNA CTD PMID:24136188 NCBI chr 9:15,393,461...15,403,212
Ensembl chr 9:15,393,330...15,403,117
JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 increases expression EXP nefazodone results in increased expression of BZW1 mRNA CTD PMID:24136188 NCBI chr 9:65,279,675...65,293,471
Ensembl chr 9:65,279,675...65,291,651
JBrowse link
G C1galt1c1 C1GALT1-specific chaperone 1 increases expression EXP nefazodone results in increased expression of C1GALT1C1 mRNA CTD PMID:24136188 NCBI chr  X:124,921,686...124,926,171
Ensembl chr  X:124,921,728...124,926,171
JBrowse link
G C1qbp complement C1q binding protein increases expression EXP nefazodone results in increased expression of C1QBP mRNA CTD PMID:24136188 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G C1r complement C1r decreases expression EXP nefazodone results in decreased expression of C1R mRNA CTD PMID:24136188 NCBI chr 4:157,126,060...157,136,825
Ensembl chr 4:157,125,998...157,136,829
JBrowse link
G C1s complement C1s decreases expression EXP nefazodone results in decreased expression of C1S mRNA CTD PMID:24136188 NCBI chr 4:157,143,592...157,155,592
Ensembl chr 4:157,143,592...157,155,609
JBrowse link
G C2 complement C2 decreases expression EXP nefazodone results in decreased expression of C2 mRNA CTD PMID:24136188 NCBI chr20:4,542,340...4,561,152
Ensembl chr20:4,542,340...4,561,152
JBrowse link
G C4b complement C4B (Chido blood group) decreases expression EXP nefazodone results in decreased expression of C4B mRNA CTD PMID:24136188 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
JBrowse link
G C5 complement C5 decreases expression EXP nefazodone results in decreased expression of C5 mRNA CTD PMID:24136188 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G C6 complement C6 decreases expression EXP nefazodone results in decreased expression of C6 mRNA CTD PMID:24136188 NCBI chr 2:54,460,333...54,533,801
Ensembl chr 2:54,466,280...54,533,797
JBrowse link
G C8a complement C8 alpha chain decreases expression EXP nefazodone results in decreased expression of C8A mRNA CTD PMID:24136188 NCBI chr 5:124,348,536...124,403,117
Ensembl chr 5:124,348,461...124,403,195
JBrowse link
G C8b complement C8 beta chain decreases expression EXP nefazodone results in decreased expression of C8B mRNA CTD PMID:24136188 NCBI chr 5:124,298,269...124,338,055
Ensembl chr 5:124,300,477...124,338,053
JBrowse link
G C9 complement C9 decreases expression EXP nefazodone results in decreased expression of C9 mRNA CTD PMID:24136188 NCBI chr 2:55,775,562...55,823,807
Ensembl chr 2:55,775,274...55,823,826
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP nefazodone results in decreased expression of CAR3 mRNA CTD PMID:24136188 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Ca8 carbonic anhydrase 8 decreases expression EXP nefazodone results in decreased expression of CAR8 mRNA CTD PMID:24136188 NCBI chr 5:21,249,018...21,345,810
Ensembl chr 5:21,249,020...21,345,810
JBrowse link
G Cab39 calcium binding protein 39 increases expression EXP nefazodone results in increased expression of CAB39 mRNA CTD PMID:24136188 NCBI chr 9:92,834,327...92,895,778
Ensembl chr 9:92,834,357...92,895,778
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C affects activity ISO nefazodone affects the activity of CACNA1C protein CTD PMID:26821276 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Cacul1 CDK2-associated, cullin domain 1 increases expression EXP nefazodone results in increased expression of CACUL1 mRNA CTD PMID:24136188 NCBI chr 1:281,814,226...281,874,675
Ensembl chr 1:281,816,407...281,874,511
JBrowse link
G Cacybp calcyclin binding protein increases expression EXP nefazodone results in increased expression of CACYBP mRNA CTD PMID:24136188 NCBI chr13:77,948,771...77,959,089
Ensembl chr13:77,948,771...77,959,110
JBrowse link
G Cald1 caldesmon 1 decreases expression EXP nefazodone results in decreased expression of CALD1 mRNA CTD PMID:24136188 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
JBrowse link
G Calm2 calmodulin 2 decreases expression EXP nefazodone results in decreased expression of CALM2 mRNA CTD PMID:24136188 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Caprin1 cell cycle associated protein 1 increases expression EXP nefazodone results in increased expression of CAPRIN1 mRNA CTD PMID:24136188 NCBI chr 3:93,701,830...93,789,580
Ensembl chr 3:93,702,487...93,789,617
JBrowse link
G Carhsp1 calcium regulated heat stable protein 1 decreases expression EXP nefazodone results in decreased expression of CARHSP1 mRNA CTD PMID:24136188 NCBI chr10:7,041,510...7,055,107
Ensembl chr10:7,041,510...7,055,101
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
ISO
EXP
Palmitic Acid promotes the reaction [nefazodone results in increased activity of CASP3 protein]
nefazodone results in increased expression of CASP3 mRNA
CTD PMID:22700542 PMID:24136188 PMID:27288927 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO nefazodone results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [nefazodone results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 increases activity ISO nefazodone results in increased activity of CASP9 protein CTD PMID:27288927 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases expression
multiple interactions
ISO nefazodone results in decreased expression of CAT mRNA
[nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CAT mRNA
CTD PMID:32152650 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cavin3 caveolae associated protein 3 increases expression EXP nefazodone results in increased expression of CAVIN3 mRNA CTD PMID:24136188 NCBI chr 1:170,317,099...170,318,688
Ensembl chr 1:170,317,113...170,318,935
JBrowse link
G Cbr1 carbonyl reductase 1 increases expression
multiple interactions
EXP
ISO
nefazodone results in increased expression of CBR1 mRNA
[nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CBR1 mRNA
CTD PMID:24136188 PMID:32152650 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Cbr4 carbonyl reductase 4 increases expression EXP nefazodone results in increased expression of CBR4 mRNA CTD PMID:24136188 NCBI chr16:31,944,328...31,972,553
Ensembl chr16:31,956,753...31,972,507
JBrowse link
G Cbx3 chromobox 3 increases expression EXP nefazodone results in increased expression of CBX3 mRNA CTD PMID:24136188 NCBI chr 4:81,243,809...81,257,898
Ensembl chr 4:81,244,469...81,257,897
JBrowse link
G Ccdc107 coiled-coil domain containing 107 decreases expression EXP nefazodone results in decreased expression of CCDC107 mRNA CTD PMID:24136188 NCBI chr 5:58,995,211...58,998,620
Ensembl chr 5:58,995,249...58,997,953
JBrowse link
G Ccdc47 coiled-coil domain containing 47 increases expression EXP nefazodone results in increased expression of CCDC47 mRNA CTD PMID:24136188 NCBI chr10:94,388,425...94,406,949
Ensembl chr10:94,388,430...94,406,949
JBrowse link
G Ccdc6 coiled-coil domain containing 6 increases expression EXP nefazodone results in increased expression of CCDC6 mRNA CTD PMID:24136188 NCBI chr20:19,729,005...19,825,219
Ensembl chr20:19,732,894...19,825,150
JBrowse link
G Ccdc80 coiled-coil domain containing 80 decreases expression EXP nefazodone results in decreased expression of CCDC80 mRNA CTD PMID:24136188 NCBI chr11:60,645,660...60,679,249
Ensembl chr11:60,645,086...60,679,555
JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 decreases expression EXP nefazodone results in decreased expression of CCL6 mRNA CTD PMID:24136188 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782
JBrowse link
G Ccnl1 cyclin L1 decreases expression EXP nefazodone results in decreased expression of CCNL1 mRNA CTD PMID:24136188 NCBI chr 2:157,747,295...157,759,838
Ensembl chr 2:157,747,542...157,759,838
JBrowse link
G Ccnl2 cyclin L2 decreases expression EXP nefazodone results in decreased expression of CCNL2 mRNA CTD PMID:24136188 NCBI chr 5:173,256,301...173,268,279
Ensembl chr 5:173,256,637...173,276,169
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression
multiple interactions
ISO nefazodone results in increased expression of CCR2 mRNA
[nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of CCR2 mRNA
CTD PMID:32152650
G Ccs copper chaperone for superoxide dismutase increases expression EXP nefazodone results in increased expression of CCS mRNA CTD PMID:24136188 NCBI chr 1:220,075,251...220,096,319
Ensembl chr 1:220,075,247...220,096,404
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 increases expression EXP nefazodone results in increased expression of CCT2 mRNA CTD PMID:24136188 NCBI chr 7:60,106,532...60,122,779
Ensembl chr 7:60,109,974...60,122,805
JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 increases expression EXP nefazodone results in increased expression of CCT3 mRNA CTD PMID:24136188 NCBI chr 2:187,669,051...187,693,610
Ensembl chr 2:187,668,796...187,693,610
JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 increases expression EXP nefazodone results in increased expression of CCT4 mRNA CTD PMID:24136188 NCBI chr14:107,767,392...107,780,270
Ensembl chr14:107,767,392...107,780,270
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 increases expression EXP nefazodone results in increased expression of CCT5 mRNA CTD PMID:24136188 NCBI chr 2:84,667,578...84,678,730
Ensembl chr 2:84,667,633...84,678,790
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A increases expression EXP nefazodone results in increased expression of CCT6A mRNA CTD PMID:24136188 NCBI chr12:30,491,584...30,501,813
Ensembl chr12:30,491,416...30,501,860
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 increases expression EXP nefazodone results in increased expression of CCT7 mRNA CTD PMID:24136188 NCBI chr 4:117,235,023...117,252,265
Ensembl chr 4:117,235,023...117,252,265
JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 increases expression EXP nefazodone results in increased expression of CCT8 mRNA CTD PMID:24136188 NCBI chr11:27,130,172...27,141,881
Ensembl chr11:27,130,172...27,141,881
JBrowse link
G Cd14 CD14 molecule increases expression EXP nefazodone results in increased expression of CD14 mRNA CTD PMID:24136188 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd164 CD164 molecule decreases expression EXP nefazodone results in decreased expression of CD164 mRNA CTD PMID:24136188 NCBI chr20:46,250,418...46,261,994
Ensembl chr20:46,250,363...46,261,994
JBrowse link
G Cd302 CD302 molecule decreases expression EXP nefazodone results in decreased expression of CD302 mRNA CTD PMID:24136188 NCBI chr 3:46,327,382...46,361,092
Ensembl chr 3:46,327,383...46,361,092
JBrowse link
G Cd5l Cd5 molecule-like decreases expression EXP nefazodone results in decreased expression of CD5L mRNA CTD PMID:24136188 NCBI chr 2:186,685,104...186,696,117
Ensembl chr 2:186,685,104...186,696,117
JBrowse link
G Cd74 CD74 molecule decreases expression EXP nefazodone results in decreased expression of CD74 mRNA CTD PMID:24136188 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cd81 Cd81 molecule decreases expression EXP nefazodone results in decreased expression of CD81 mRNA CTD PMID:24136188 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311
JBrowse link
G Cd82 Cd82 molecule decreases expression EXP nefazodone results in decreased expression of CD82 mRNA CTD PMID:24136188 NCBI chr 3:82,324,344...82,368,846
Ensembl chr 3:82,324,354...82,368,357
JBrowse link
G Cdc40 cell division cycle 40 increases expression EXP nefazodone results in increased expression of CDC40 mRNA CTD PMID:24136188 NCBI chr20:48,503,973...48,574,546
Ensembl chr20:48,503,973...48,574,546
JBrowse link
G Cdc73 cell division cycle 73 increases expression EXP nefazodone results in increased expression of CDC73 mRNA CTD PMID:24136188 NCBI chr13:60,403,771...60,496,511
Ensembl chr13:60,403,771...60,496,511
JBrowse link
G Cdh2 cadherin 2 decreases expression EXP nefazodone results in decreased expression of CDH2 mRNA CTD PMID:24136188 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP nefazodone results in increased expression of CDK4 mRNA CTD PMID:24136188 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk7 cyclin-dependent kinase 7 increases expression EXP nefazodone results in increased expression of CDK7 mRNA CTD PMID:24136188 NCBI chr 2:30,710,642...30,735,522
Ensembl chr 2:30,710,643...30,735,514
JBrowse link
G Cdo1 cysteine dioxygenase type 1 decreases expression EXP nefazodone results in decreased expression of CDO1 mRNA CTD PMID:24136188 NCBI chr18:40,702,027...40,716,901
Ensembl chr18:40,701,984...40,716,686
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 decreases expression EXP nefazodone results in decreased expression of CEACAM1 mRNA CTD PMID:24136188 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Cela1 chymotrypsin like elastase 1 decreases expression EXP nefazodone results in decreased expression of CELA1 mRNA CTD PMID:24136188 NCBI chr 7:142,305,337...142,318,621
Ensembl chr 7:142,305,338...142,318,620
JBrowse link
G Cenpv centromere protein V increases expression EXP nefazodone results in increased expression of CENPV mRNA CTD PMID:24136188 NCBI chr10:48,846,513...48,861,893
Ensembl chr10:48,846,728...48,860,902
JBrowse link
G Cep170 centrosomal protein 170 decreases expression EXP nefazodone results in decreased expression of CEP170 mRNA CTD PMID:24136188 NCBI chr13:94,807,090...94,887,448
Ensembl chr13:94,807,756...94,859,436
JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP nefazodone results in increased expression of CES2 mRNA CTD PMID:24136188 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Cfap20 cilia and flagella associated protein 20 increases expression EXP nefazodone results in increased expression of CFAP20 mRNA CTD PMID:24136188 NCBI chr19:10,024,938...10,038,838
Ensembl chr19:10,024,947...10,038,784
JBrowse link
G Cfap298 cilia and flagella associated protein 298 increases expression EXP nefazodone results in increased expression of CFAP298 mRNA CTD PMID:24136188 NCBI chr11:31,094,103...31,103,487
Ensembl chr11:31,094,084...31,103,520
JBrowse link
G Cfb complement factor B decreases expression EXP nefazodone results in decreased expression of CFB mRNA CTD PMID:24136188 NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066
Ensembl chr20:4,536,203...4,561,066
JBrowse link
G Cfh complement factor H decreases expression EXP nefazodone results in decreased expression of CFH mRNA CTD PMID:24136188 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Cfhr1 complement factor H-related 1 decreases expression EXP nefazodone results in decreased expression of CFHR1 mRNA CTD PMID:24136188 NCBI chr13:56,862,666...56,877,650
Ensembl chr13:56,836,994...56,877,650
JBrowse link
G Cgn cingulin decreases expression EXP nefazodone results in decreased expression of CGN mRNA CTD PMID:24136188 NCBI chr 2:195,909,691...195,937,130
Ensembl chr 2:195,909,626...195,935,878
JBrowse link
G Cgnl1 cingulin-like 1 decreases expression EXP nefazodone results in decreased expression of CGNL1 mRNA CTD PMID:24136188 NCBI chr 8:78,126,670...78,278,490
Ensembl chr 8:78,126,675...78,233,430
JBrowse link
G Cgrrf1 cell growth regulator with ring finger domain 1 increases expression EXP nefazodone results in increased expression of CGRRF1 mRNA CTD PMID:24136188 NCBI chr15:23,619,176...23,639,622
Ensembl chr15:23,619,123...23,639,628
JBrowse link
G Chac2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 decreases expression EXP nefazodone results in decreased expression of CHAC2 mRNA CTD PMID:24136188 NCBI chr14:115,383,906...115,391,757
Ensembl chr14:115,383,910...115,391,652
JBrowse link
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 increases expression EXP nefazodone results in increased expression of CHCHD10 mRNA CTD PMID:24136188 NCBI chr20:13,665,046...13,666,845
Ensembl chr20:13,665,031...13,667,333
JBrowse link
G Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 increases expression EXP nefazodone results in increased expression of CHCHD2 mRNA CTD PMID:24136188 NCBI chr 9:101,388,148...101,388,819
Ensembl chr 9:101,388,151...101,388,833
JBrowse link
G Chchd5 coiled-coil-helix-coiled-coil-helix domain containing 5 increases expression EXP nefazodone results in increased expression of CHCHD5 mRNA CTD PMID:24136188 NCBI chr 3:121,659,962...121,664,286
Ensembl chr 3:121,660,110...121,664,496
JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 increases expression EXP nefazodone results in increased expression of CHCHD6 mRNA CTD PMID:24136188 NCBI chr 4:121,340,952...121,565,222
Ensembl chr 4:121,340,952...121,565,212
JBrowse link
G Chka choline kinase alpha decreases expression EXP nefazodone results in decreased expression of CHKA mRNA CTD PMID:24136188 NCBI chr 1:219,076,618...219,126,221
Ensembl chr 1:219,077,771...219,126,220
JBrowse link
G Chmp4c charged multivesicular body protein 4C increases expression EXP nefazodone results in increased expression of CHMP4C mRNA CTD PMID:24136188 NCBI chr 2:93,574,554...93,641,497
Ensembl chr 2:93,574,559...93,641,497
JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression EXP nefazodone results in increased expression of CHORDC1 mRNA CTD PMID:24136188 NCBI chr 8:17,421,552...17,445,513
Ensembl chr 8:17,421,557...17,446,165
JBrowse link
G Chpf2 chondroitin polymerizing factor 2 increases expression EXP nefazodone results in increased expression of CHPF2 mRNA CTD PMID:24136188 NCBI chr 4:7,108,461...7,113,940
Ensembl chr 4:7,108,462...7,113,919
JBrowse link
G Chpt1 choline phosphotransferase 1 increases expression EXP nefazodone results in increased expression of CHPT1 mRNA CTD PMID:24136188 NCBI chr 7:29,019,518...29,070,928
Ensembl chr 7:29,043,916...29,070,928
JBrowse link
G Chrac1 chromatin accessibility complex subunit 1 increases expression EXP nefazodone results in increased expression of CHRAC1 mRNA CTD PMID:24136188 NCBI chr 7:114,323,542...114,326,930
Ensembl chr 7:114,323,542...114,326,930
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex increases expression EXP nefazodone results in increased expression of CHUK mRNA CTD PMID:24136188 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Churc1 churchill domain containing 1 increases expression EXP nefazodone results in increased expression of CHURC1 mRNA CTD PMID:24136188 NCBI chr 6:99,817,439...99,831,574
Ensembl chr 6:99,817,431...99,831,576
JBrowse link
G Ciao2a cytosolic iron-sulfur assembly component 2A increases expression EXP nefazodone results in increased expression of CIAO2A mRNA CTD PMID:24136188 NCBI chr 8:71,786,336...71,798,258
Ensembl chr 8:71,786,310...71,798,266
JBrowse link
G Ciapin1 cytokine induced apoptosis inhibitor 1 increases expression EXP nefazodone results in increased expression of CIAPIN1 mRNA CTD PMID:24136188 NCBI chr19:10,596,923...10,612,414
Ensembl chr19:10,596,960...10,610,049
JBrowse link
G Cidea cell death-inducing DFFA-like effector a increases expression EXP nefazodone results in increased expression of CIDEA mRNA CTD PMID:24136188 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
JBrowse link
G Cidec cell death-inducing DFFA-like effector c decreases expression EXP nefazodone results in decreased expression of CIDEC mRNA CTD PMID:24136188 NCBI chr 4:145,377,482...145,390,497
Ensembl chr 4:145,377,431...145,390,497
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP nefazodone results in decreased expression of CITED2 mRNA CTD PMID:24136188 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B increases expression EXP nefazodone results in increased expression of CKS1B mRNA CTD PMID:24136188 NCBI chr 2:188,740,564...188,745,144
Ensembl chr 2:188,740,573...188,745,144
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression EXP nefazodone results in decreased expression of CKS2 mRNA CTD PMID:24136188 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
JBrowse link
G Clcn3 chloride voltage-gated channel 3 increases expression EXP nefazodone results in increased expression of CLCN3 mRNA CTD PMID:24136188 NCBI chr16:32,448,821...32,520,649
Ensembl chr16:32,449,116...32,519,148
JBrowse link
G Clcn4 chloride voltage-gated channel 4 decreases expression EXP nefazodone results in decreased expression of CLCN4 mRNA CTD PMID:24136188 NCBI chr  X:25,016,177...25,082,563
Ensembl chr  X:25,016,401...25,080,410
JBrowse link
G Cldnd1 claudin domain containing 1 increases expression EXP nefazodone results in increased expression of CLDND1 mRNA CTD PMID:24136188 NCBI chr11:43,986,352...43,992,703
Ensembl chr11:43,986,386...43,992,598
JBrowse link
G Clec4f C-type lectin domain family 4, member F decreases expression EXP nefazodone results in decreased expression of CLEC4F mRNA CTD PMID:24136188 NCBI chr 4:115,322,300...115,332,021
Ensembl chr 4:115,322,291...115,332,052
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 increases expression EXP nefazodone results in increased expression of CLIP1 mRNA CTD PMID:24136188 NCBI chr12:38,345,203...38,452,650
Ensembl chr12:38,345,456...38,452,652
JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit increases expression EXP nefazodone results in increased expression of CLPP mRNA CTD PMID:24136188 NCBI chr 9:10,048,715...10,056,068
Ensembl chr 9:10,048,886...10,054,359
JBrowse link
G Cltb clathrin, light chain B increases expression EXP nefazodone results in increased expression of CLTB mRNA CTD PMID:24136188 NCBI chr17:10,537,348...10,554,999
Ensembl chr17:10,537,365...10,554,989
JBrowse link
G Cltc clathrin heavy chain increases expression EXP nefazodone results in increased expression of CLTC mRNA CTD PMID:24136188 NCBI chr10:74,014,560...74,070,578
Ensembl chr10:74,014,562...74,070,266
JBrowse link
G Cmas cytidine monophosphate N-acetylneuraminic acid synthetase increases expression EXP nefazodone results in increased expression of CMAS mRNA CTD PMID:24136188 NCBI chr 4:176,994,129...177,012,445
Ensembl chr 4:176,994,129...177,012,444
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog increases expression EXP nefazodone results in increased expression of CMBL mRNA CTD PMID:24136188 NCBI chr 2:84,645,084...84,666,836
Ensembl chr 2:84,645,084...84,666,835
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 decreases expression EXP nefazodone results in decreased expression of CMTM6 mRNA CTD PMID:24136188 NCBI chr 8:122,789,208...122,807,560
Ensembl chr 8:122,789,453...122,807,560
JBrowse link
G Cmtm8 CKLF-like MARVEL transmembrane domain containing 8 increases expression EXP nefazodone results in increased expression of CMTM8 mRNA CTD PMID:24136188 NCBI chr 8:122,848,249...122,913,597
Ensembl chr 8:122,848,501...122,904,913
JBrowse link
G Cnot11 CCR4-NOT transcription complex, subunit 11 increases expression EXP nefazodone results in increased expression of CNOT11 mRNA CTD PMID:24136188 NCBI chr 9:46,270,229...46,279,928
Ensembl chr 9:46,270,122...46,279,995
JBrowse link
G Coa3 cytochrome C oxidase assembly factor 3 increases expression EXP nefazodone results in increased expression of COA3 mRNA CTD PMID:24136188 NCBI chr10:89,198,750...89,199,731
Ensembl chr10:89,198,749...89,199,736
JBrowse link
G Coa5 cytochrome C oxidase assembly factor 5 increases expression EXP nefazodone results in increased expression of COA5 mRNA CTD PMID:24136188 NCBI chr 9:44,011,471...44,024,876
Ensembl chr 9:44,011,471...44,024,876
JBrowse link
G Coasy Coenzyme A synthase increases expression EXP nefazodone results in increased expression of COASY mRNA CTD PMID:24136188 NCBI chr10:88,992,413...88,996,677
Ensembl chr10:88,992,487...88,996,676
JBrowse link
G Cog6 component of oligomeric golgi complex 6 increases expression EXP nefazodone results in increased expression of COG6 mRNA CTD PMID:24136188 NCBI chr 2:142,197,566...142,235,054
Ensembl chr 2:142,196,754...142,235,066
JBrowse link
G Col14a1 collagen type XIV alpha 1 chain decreases expression EXP nefazodone results in decreased expression of COL14A1 mRNA CTD PMID:24136188 NCBI chr 7:95,054,877...95,274,073
Ensembl chr 7:95,074,236...95,273,298
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression EXP nefazodone results in decreased expression of COL18A1 mRNA CTD PMID:24136188 NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858
JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression EXP nefazodone results in decreased expression of COL1A2 mRNA CTD PMID:24136188 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression EXP nefazodone results in decreased expression of COL3A1 mRNA CTD PMID:24136188 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Col6a1 collagen type VI alpha 1 chain decreases expression EXP nefazodone results in decreased expression of COL6A1 mRNA CTD PMID:24136188 NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561
JBrowse link
G Commd5 COMM domain containing 5 increases expression EXP nefazodone results in increased expression of COMMD5 mRNA CTD PMID:24136188 NCBI chr 7:117,963,213...117,965,010
Ensembl chr 7:118,502,676...118,504,097
Ensembl chr 7:118,502,676...118,504,097
JBrowse link
G Comtd1 catechol-O-methyltransferase domain containing 1 increases expression EXP nefazodone results in increased expression of COMTD1 mRNA CTD PMID:24136188 NCBI chr15:2,631,529...2,634,640
Ensembl chr15:2,631,529...2,634,640
JBrowse link
G Cope COPI coat complex subunit epsilon increases expression EXP nefazodone results in increased expression of COPE mRNA CTD PMID:24136188 NCBI chr16:20,863,141...20,873,516
Ensembl chr16:20,863,141...20,873,521
JBrowse link
G Cops4 COP9 signalosome subunit 4 increases expression EXP nefazodone results in increased expression of COPS4 mRNA CTD PMID:24136188 NCBI chr14:10,718,863...10,749,134
Ensembl chr14:10,718,844...10,749,120
JBrowse link
G Cops5 COP9 signalosome subunit 5 increases expression EXP nefazodone results in increased expression of COPS5 mRNA CTD PMID:24136188 NCBI chr 5:8,876,090...8,894,345
Ensembl chr 5:8,876,044...8,894,339
JBrowse link
G Cops7a COP9 signalosome subunit 7A increases expression EXP nefazodone results in increased expression of COPS7A mRNA CTD PMID:24136188 NCBI chr 4:157,479,549...157,486,944
Ensembl chr 4:157,479,549...157,486,914
JBrowse link
G Coq10a coenzyme Q10A decreases expression EXP nefazodone results in decreased expression of COQ10A mRNA CTD PMID:24136188 NCBI chr 7:2,780,930...2,788,189
Ensembl chr 7:2,780,930...2,786,949
JBrowse link
G Coq6 coenzyme Q6 monooxygenase increases expression EXP nefazodone results in increased expression of COQ6 mRNA CTD PMID:24136188 NCBI chr 6:108,076,393...108,087,782
Ensembl chr 6:108,076,306...108,087,696
JBrowse link
G Coq8a coenzyme Q8A decreases expression EXP nefazodone results in decreased expression of COQ8A mRNA CTD PMID:24136188 NCBI chr13:98,451,629...98,480,438
Ensembl chr13:98,451,637...98,480,419
JBrowse link
G Coro1c coronin 1C decreases expression EXP nefazodone results in decreased expression of CORO1C mRNA CTD PMID:24136188 NCBI chr12:48,481,741...48,554,054
Ensembl chr12:48,481,750...48,554,052
JBrowse link
G Cox14 cytochrome c oxidase assembly factor COX14 increases expression EXP nefazodone results in increased expression of COX14 mRNA CTD PMID:24136188 NCBI chr 7:141,378,537...141,380,960
Ensembl chr 7:141,380,322...141,380,495
JBrowse link
G Cox19 cytochrome c oxidase assembly factor COX19 increases expression EXP nefazodone results in increased expression of COX19 mRNA CTD PMID:24136188 NCBI chr12:17,395,624...17,405,103
Ensembl chr12:17,395,624...17,405,103