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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:metal hydride
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Accession:CHEBI:37761 term browser browse the term


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beryllium dihydride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP [Beryllium results in increased methylation of CDKN2A promoter] which results in decreased expression of CDKN2A mRNA CTD PMID:11872642 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Esr1 estrogen receptor 1 increases methylation EXP Beryllium results in increased methylation of ESR1 gene CTD PMID:11872642 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Hras HRas proto-oncogene, GTPase increases mutagenesis EXP Beryllium results in increased mutagenesis of HRAS gene CTD PMID:7545909 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Il1b interleukin 1 beta increases expression
affects expression
ISO Beryllium results in increased expression of IL1B mRNA
Beryllium affects the expression of IL1B mRNA
CTD PMID:8473757 PMID:8629860 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Tnf tumor necrosis factor increases expression
increases response to substance
increases secretion
ISO Beryllium results in increased expression of TNF mRNA
TNF promoter polymorphism results in increased susceptibility to Beryllium
Beryllium results in increased secretion of TNF protein
CTD PMID:8629860 PMID:12449171 PMID:15127972 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
lithium hydride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aanat aralkylamine N-acetyltransferase multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in decreased expression of AANAT mRNA] CTD PMID:19149911 NCBI chr10:101,827,072...101,831,805
Ensembl chr10:101,827,301...101,831,801
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP Lithium results in increased expression of ABCB1B mRNA; Lithium results in increased expression of ABCB1B protein CTD PMID:19570321 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in increased expression of ACSL5 mRNA] CTD PMID:19149911 NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
JBrowse link
G Actb actin, beta increases expression EXP Lithium results in increased expression of ACTB protein CTD PMID:18296634 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Actr3 actin related protein 3 increases expression EXP Lithium results in increased expression of ACTR3 protein CTD PMID:18296634 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124
JBrowse link
G Adk adenosine kinase increases expression EXP Lithium results in increased expression of ADK protein CTD PMID:18296634 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
JBrowse link
G Adnp2 ADNP homeobox 2 increases expression ISO Lithium results in increased expression of ADNP2 mRNA CTD PMID:19949822 NCBI chr18:73,571,870...73,597,088
Ensembl chr18:73,571,936...73,628,484
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
increases expression
ISO Lithium results in increased phosphorylation of AKT1 protein
Lithium results in increased expression of AKT1 mRNA; Lithium results in increased expression of AKT1 protein
CTD PMID:19440698 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 decreases expression EXP Lithium results in decreased expression of ALDH1A3 protein CTD PMID:18296634 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
JBrowse link
G Antxr2 ANTXR cell adhesion molecule 2 increases expression ISO Lithium results in increased expression of ANTXR2 mRNA CTD PMID:21092101 NCBI chr14:11,542,266...11,682,112
Ensembl chr14:11,541,772...11,682,094
JBrowse link
G Anxa2 annexin A2 decreases expression EXP Lithium results in decreased expression of ANXA2 protein CTD PMID:18296634 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Anxa4 annexin A4 increases expression EXP Lithium results in increased expression of ANXA4 protein CTD PMID:18296634 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
JBrowse link
G Anxa5 annexin A5 increases expression EXP Lithium results in increased expression of ANXA5 protein CTD PMID:18296634 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO
EXP
Lithium inhibits the reaction [APP protein binds to APP protein]
Lithium inhibits the reaction [APP protein alternative form results in decreased expression of BCL2 protein]
CTD PMID:10762662 PMID:19621015 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aprt adenine phosphoribosyl transferase increases expression EXP Lithium results in increased expression of APRT protein CTD PMID:18296634 NCBI chr19:50,626,436...50,628,404
Ensembl chr19:50,626,202...50,628,431
JBrowse link
G Aqp2 aquaporin 2 multiple interactions
decreases expression
increases expression
ISO
EXP
Lithium inhibits the reaction [Deamino Arginine Vasopressin results in increased expression of AQP2 mRNA]; Lithium inhibits the reaction [Deamino Arginine Vasopressin results in increased expression of AQP2 protein]; PRKCA gene mutant form inhibits the reaction [Lithium results in decreased expression of AQP2 protein]
Lithium results in increased expression of AQP2 protein
Lithium results in decreased expression of AQP2 mRNA; Lithium results in decreased expression of AQP2 protein
[Aldosterone co-treated with Lithium] affects the expression of AQP2 protein; [Spironolactone co-treated with Lithium] affects the expression of AQP2 protein; Hydrochlorothiazide inhibits the reaction [Lithium results in decreased expression of AQP2 protein]
CTD PMID:7535800 PMID:10966935 PMID:12472779 PMID:14613889 PMID:15153756 More... NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) decreases expression EXP Lithium results in decreased expression of AQP3 protein CTD PMID:10966935 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Aqp6 aquaporin 6 increases expression EXP Lithium results in increased expression of AQP6 mRNA; Lithium results in increased expression of AQP6 protein CTD PMID:11097619 NCBI chr 7:130,732,216...130,735,149
Ensembl chr 7:130,633,579...130,735,194
Ensembl chr 7:130,633,579...130,735,194
JBrowse link
G Arg2 arginase 2 multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in increased expression of ARG2 mRNA] CTD PMID:19149911 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions EXP [Lithium co-treated with Pilocarpine] results in decreased expression of ATF2 protein CTD PMID:19430551 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atm ATM serine/threonine kinase decreases expression ISO Lithium results in decreased expression of ATM mRNA CTD PMID:19949822 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 decreases expression
increases expression
multiple interactions
EXP
ISO
Lithium results in decreased expression of ATP1A1 mRNA
Lithium results in increased expression of ATP1A1 protein
Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA]; Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein]
CTD PMID:15153756 PMID:18296634 PMID:19995221 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 multiple interactions ISO Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA] CTD PMID:19995221 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in decreased expression of ATP2A2 mRNA] CTD PMID:19149911 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression EXP Lithium results in increased expression of ATP5F1B protein CTD PMID:18296634 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta increases expression EXP Lithium results in increased expression of ATP5F1D protein CTD PMID:18296634 NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929
JBrowse link
G Avp arginine vasopressin affects expression
increases expression
multiple interactions
EXP Lithium affects the expression of AVP protein
Lithium results in increased expression of AVP protein
Chlorpromazine inhibits the reaction [Lithium results in increased expression of AVP protein]
CTD PMID:2454589 PMID:3976404 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bag1 BAG cochaperone 1 increases expression EXP Lithium results in increased expression of BAG1 mRNA; Lithium results in increased expression of BAG1 protein CTD PMID:15872096 NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
ISO
EXP
[Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; [Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Paraquat results in increased expression of BAX protein]; [Lithium Chloride results in increased abundance of Lithium] which results in decreased expression of BAX mRNA; [Lithium Chloride results in increased abundance of Lithium] which results in decreased expression of BAX protein; Lithium inhibits the reaction [sodium arsenite affects the localization of BAX protein]; Lithium inhibits the reaction [sodium arsenite promotes the reaction [BAX protein binds to BAX protein]]
Lithium inhibits the reaction [Cadmium results in increased expression of BAX protein]; Lithium inhibits the reaction [Methamphetamine results in increased expression of BAX protein]; Lithium inhibits the reaction [Morphine results in increased expression of BAX mRNA]
Lithium results in decreased expression of BAX mRNA
CTD PMID:17849503 PMID:18976035 PMID:19149911 PMID:19949822 PMID:20455018 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
[Lithium Chloride results in increased abundance of Lithium] promotes the reaction [Paraquat results in increased expression of BCL2 mRNA]; [Lithium Chloride results in increased abundance of Lithium] which results in increased expression of BCL2 mRNA; [Lithium Chloride results in increased abundance of Lithium] which results in increased expression of BCL2 protein; [Paraquat co-treated with [Lithium Chloride results in increased abundance of Lithium]] results in increased expression of BCL2 protein; Lithium inhibits the reaction [Ethanol results in decreased expression of BCL2 mRNA]
Lithium results in increased expression of BCL2; Lithium results in increased expression of BCL2 mRNA; Lithium results in increased expression of BCL2 protein
Lithium inhibits the reaction [APP protein alternative form results in decreased expression of BCL2 protein]; Lithium inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; Lithium inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]; Lithium inhibits the reaction [Morphine results in decreased expression of BCL2 mRNA]
CTD PMID:10762662 PMID:15581403 PMID:16288908 PMID:18976035 PMID:19149911 More... NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor affects response to substance
multiple interactions
increases expression
decreases expression
increases response to substance
ISO
EXP
BDNF gene polymorphism affects the susceptibility to Lithium
[Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Paraquat results in decreased expression of BDNF mRNA]; [Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Paraquat results in decreased secretion of BDNF protein]; [Lithium Chloride results in increased abundance of Lithium] which results in increased expression of BDNF mRNA; [Lithium Chloride results in increased abundance of Lithium] which results in increased secretion of BDNF protein
Lithium results in increased expression of BDNF mRNA; Lithium results in increased expression of BDNF protein
Lithium results in decreased expression of BDNF mRNA
Diazepam inhibits the reaction [Lithium results in increased expression of BDNF mRNA]; Lithium inhibits the reaction [Dextroamphetamine results in decreased expression of BDNF protein]; Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein]
BDNF protein results in increased susceptibility to Lithium
CTD PMID:9073163 PMID:16460767 PMID:17442489 PMID:19018715 PMID:19954800 More... NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression EXP Lithium results in increased expression of BIRC5 mRNA CTD PMID:16288908 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B increases expression EXP Lithium results in increased expression of BUB1B mRNA CTD PMID:21711903 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
JBrowse link
G Calr calreticulin increases expression EXP Lithium results in increased expression of CALR mRNA; Lithium results in increased expression of CALR protein CTD PMID:16236328 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV increases expression EXP Lithium results in increased expression of CAMK4 mRNA; Lithium results in increased expression of CAMK4 protein CTD PMID:19711354 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 increases expression EXP Lithium results in increased expression of CAMKK2 protein CTD PMID:19289156 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
JBrowse link
G Car2 carbonic anhydrase 2 increases expression EXP Lithium results in increased expression of CA2 protein CTD PMID:18296634 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp12 caspase 12 multiple interactions EXP [Pilocarpine co-treated with Lithium] results in increased expression of CASP12 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein] CTD PMID:21429313 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
EXP
ISO
[Pilocarpine co-treated with Lithium] results in increased activity of CASP3 protein; Lithium inhibits the reaction [Cadmium results in increased expression of CASP3 protein]; Lithium inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased activity of CASP3 protein]
Lithium results in decreased activity of CASP3 protein
[Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; Lithium inhibits the reaction [Monensin results in increased activity of CASP3 protein]; Lithium inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]
CTD PMID:15005753 PMID:15581403 PMID:17849503 PMID:20149694 PMID:20455018 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in increased expression of CASP4 mRNA] CTD PMID:19149911 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Lithium inhibits the reaction [Monensin results in increased activity of CASP7 protein] CTD PMID:20799912 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Lithium inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; Lithium inhibits the reaction [Etoposide results in increased activity of CASP8 protein] CTD PMID:15475000 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase increases activity
multiple interactions
ISO
EXP
Lithium results in increased activity of CAT protein
Lithium inhibits the reaction [Ouabain results in decreased activity of CAT protein]
CTD PMID:18187119 PMID:20627318 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccna1 cyclin A1 multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in decreased expression of CCNA1 mRNA] CTD PMID:19149911 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Ccnb2 cyclin B2 increases expression EXP Lithium results in increased expression of CCNB2 mRNA CTD PMID:21711903 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in decreased expression of CCND1 mRNA] CTD PMID:19149911 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 multiple interactions ISO Lithium inhibits the reaction [Ethanol results in decreased expression of CCND2 mRNA] CTD PMID:21878650 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Cd151 CD151 molecule (Raph blood group) decreases expression EXP Lithium results in decreased expression of CD151 mRNA CTD PMID:11682256 NCBI chr 1:196,564,744...196,568,753
Ensembl chr 1:196,565,181...196,568,753
JBrowse link
G Cdca3 cell division cycle associated 3 increases expression EXP Lithium results in increased expression of CDCA3 mRNA CTD PMID:21711903 NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799
JBrowse link
G Cdh1 cadherin 1 increases expression EXP Lithium results in increased expression of CDH1 protein CTD PMID:18296634 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO TP53 affects the reaction [Lithium results in increased expression of CDKN1A protein] CTD PMID:11337498 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression EXP Lithium results in decreased expression of CDKN1B mRNA; Lithium results in decreased expression of CDKN1B protein CTD PMID:15687245 PMID:18296634 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cfl1 cofilin 1 increases expression EXP Lithium results in increased expression of CFL1 protein CTD PMID:18296634 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
JBrowse link
G Ckb creatine kinase B increases expression EXP Lithium results in increased expression of CKB protein CTD PMID:18296634 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression EXP Lithium results in increased expression of COX5A protein CTD PMID:18296634 NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B increases expression EXP Lithium results in increased expression of COX5B protein CTD PMID:18296634 NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
JBrowse link
G Crip1 cysteine rich protein 1 increases expression ISO Lithium results in increased expression of CRIP1 mRNA CTD PMID:21092101 NCBI chr 6:132,226,746...132,234,620
Ensembl chr 6:132,226,746...132,234,620
JBrowse link
G Cryab crystallin, alpha B decreases expression EXP Lithium results in decreased expression of CRYAB protein CTD PMID:18296634 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
decreases expression
multiple interactions
affects localization
ISO
EXP
Lithium results in increased expression of CTNNB1 protein
Lithium results in decreased expression of CTNNB1 mRNA
Lithium inhibits the reaction [Methamphetamine results in increased expression of CTNNB1 mRNA]; Lithium results in increased expression of and affects the localization of CTNNB1 protein
Lithium affects the localization of CTNNB1 protein
CTD PMID:12942141 PMID:16288908 PMID:18296634 PMID:19149911 PMID:19621015 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsd cathepsin D increases expression EXP Lithium results in increased expression of CTSD protein CTD PMID:18296634 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 decreases expression ISO Lithium results in decreased expression of DDR2 mRNA CTD PMID:21092101 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363
JBrowse link
G Ddx21 DExD-box helicase 21 multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in decreased expression of DDX21 mRNA] CTD PMID:19149911 NCBI chr20:30,534,319...30,554,513
Ensembl chr20:30,534,319...30,554,543
JBrowse link
G Drd1 dopamine receptor D1 affects response to substance
increases response to substance
ISO DRD1 gene polymorphism affects the susceptibility to Lithium
DRD1 protein results in increased susceptibility to Lithium
CTD PMID:19153942 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP Lithium results in decreased expression of DRD2 protein CTD PMID:16478526 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Lithium results in increased expression of DUSP1 mRNA CTD PMID:21092101 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dynlrb1 dynein light chain roadblock-type 1 increases expression EXP Lithium results in increased expression of DYNLRB1 protein CTD PMID:18296634 NCBI chr 3:143,742,427...143,764,227
Ensembl chr 3:143,742,586...143,764,227
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP Lithium results in increased expression of ECH1 protein CTD PMID:18296634 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Ect2 epithelial cell transforming 2 increases expression EXP Lithium results in increased expression of ECT2 mRNA CTD PMID:21711903 NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases expression EXP Lithium results in increased expression of EEF1A1 protein CTD PMID:18296634 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
JBrowse link
G Eif3k eukaryotic translation initiation factor 3, subunit K increases expression EXP Lithium results in increased expression of EIF3K protein CTD PMID:18296634 NCBI chr 1:84,260,125...84,270,051
Ensembl chr 1:84,259,673...84,270,302
JBrowse link
G Etfb electron transfer flavoprotein subunit beta increases expression EXP Lithium results in increased expression of ETFB protein CTD PMID:18296634 NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068
JBrowse link
G Ezr ezrin increases expression EXP Lithium results in increased expression of EZR mRNA; Lithium results in increased expression of EZR protein CTD PMID:15687245 PMID:18296634 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Lithium inhibits the reaction [Camptothecin results in increased expression of and affects the localization of FAS protein]; Lithium inhibits the reaction [Etoposide results in increased expression of and affects the localization of FAS protein] CTD PMID:15475000 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO
EXP
Lithium results in increased expression of FOS mRNA
Lithium results in increased expression of FOS protein
[Pilocarpine co-treated with Lithium] results in increased expression of FOS protein; Lithium promotes the reaction [Pilocarpine results in increased expression of FOS mRNA]
CTD PMID:7984056 PMID:8511714 PMID:9630518 PMID:11739594 PMID:17962567 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Lithium results in increased expression of FOSB mRNA CTD PMID:21092101 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Lithium inhibits the reaction [Cadmium results in decreased expression of FSHB protein] CTD PMID:20455018 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Ftl1 ferritin light chain 1 increases expression EXP Lithium results in increased expression of FTL protein CTD PMID:18296634 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G Gabpa GA binding protein transcription factor subunit alpha multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in increased expression of GABPA mRNA] CTD PMID:19149911 NCBI chr11:23,888,586...23,917,612
Ensembl chr11:23,888,815...23,917,605
JBrowse link
G Galm galactose mutarotase decreases expression EXP Lithium results in decreased expression of GALM protein CTD PMID:18296634 NCBI chr 6:14,837,540...14,889,484
Ensembl chr 6:14,837,548...14,889,310
JBrowse link
G Ganab glucosidase II alpha subunit increases expression EXP Lithium results in increased expression of GANAB protein CTD PMID:18296634 NCBI chr 1:205,793,810...205,813,701
Ensembl chr 1:205,793,895...205,813,695
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased expression of GDNF protein CTD PMID:12914250 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression EXP Lithium results in decreased expression of GJA1 protein CTD PMID:18585900 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gls glutaminase multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in decreased expression of GLS mRNA] CTD PMID:19149911 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 decreases expression
multiple interactions
EXP Lithium results in decreased expression of GOT2 protein
Lithium inhibits the reaction [Methamphetamine results in decreased expression of GOT2 mRNA]
CTD PMID:18296634 PMID:19149911 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 increases activity EXP Lithium results in increased activity of GPD1 protein CTD PMID:3224025 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in decreased expression of GPT mRNA] CTD PMID:19149911 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 decreases expression EXP Lithium results in decreased expression of GRIA1 protein CTD PMID:18171924 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions
decreases expression
EXP [Lithium co-treated with Pilocarpine] results in increased expression of GRIA2 mRNA
Lithium results in decreased expression of GRIA2 protein
CTD PMID:16819974 PMID:18171924 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 multiple interactions EXP [Lithium co-treated with Pilocarpine] results in decreased expression of GRIA3 mRNA CTD PMID:16819974 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 decreases expression
multiple interactions
ISO
EXP
Lithium results in decreased expression of GRIK2 mRNA; Lithium results in decreased expression of GRIK2 protein
[Lithium co-treated with Pilocarpine] results in increased expression of GRIK2 mRNA
CTD PMID:16819974 PMID:19596362 NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375
JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 multiple interactions EXP [Lithium co-treated with Pilocarpine] results in decreased expression of GRIK5 mRNA CTD PMID:16819974 NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2A protein CTD PMID:16600505 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2B protein CTD PMID:16600505 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression
multiple interactions
EXP
ISO
Lithium results in increased expression of GSK3A protein
Lithium promotes the reaction [sodium arsenite results in increased phosphorylation of GSK3A protein]
CTD PMID:17849503 PMID:18296634 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
decreases activity
decreases phosphorylation
increases expression
ISO
EXP
Lithium results in increased phosphorylation of GSK3B protein
Lithium inhibits the reaction [GSK3B protein binds to TP53 protein]; Lithium promotes the reaction [sodium arsenite results in increased phosphorylation of GSK3B protein]; Magnesium affects the reaction [Lithium results in decreased activity of GSK3B protein]
Lithium results in decreased phosphorylation of GSK3B protein
Lithium results in increased phosphorylation of and results in decreased activity of GSK3B protein
Lithium results in increased expression of GSK3B mRNA; Lithium results in increased expression of GSK3B protein
[Lithium results in decreased activity of GSK3B protein] which results in increased activity of MTOR protein; [Lithium results in decreased activity of GSK3B protein] which results in increased activity of NFE2L2 protein; Lithium results in increased phosphorylation of and results in decreased activity of GSK3B protein
CTD PMID:10998351 PMID:15475000 PMID:15950778 PMID:16288908 PMID:17849503 More... NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in decreased expression of GSTA3 mRNA] CTD PMID:19149911 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression EXP Lithium results in increased expression of GSTA4 mRNA CTD PMID:18082333 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP Lithium results in increased expression of GSTM1 mRNA; Lithium results in increased expression of GSTM1 protein CTD PMID:18082333 PMID:18296634 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm3l glutathione S-transferase mu 3-like increases expression EXP Lithium results in increased expression of GSTM5 mRNA CTD PMID:18082333 NCBI chr 2:195,590,450...195,612,578
Ensembl chr 2:195,607,289...195,612,475
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression EXP Lithium results in increased expression of GSTM3 mRNA CTD PMID:18082333 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Lithium results in increased expression of GSTP1 protein CTD PMID:18296634 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hhex hematopoietically expressed homeobox multiple interactions
affects expression
ISO Folic Acid inhibits the reaction [Lithium affects the expression of HHEX mRNA]; Inositol promotes the reaction [Folic Acid inhibits the reaction [Lithium affects the expression of HHEX mRNA]] CTD PMID:19638421 NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO Lithium results in decreased expression of HILPDA mRNA CTD PMID:21092101 NCBI chr 4:57,871,076...57,875,206 JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO Lithium results in increased expression of HMOX1 protein
[Lithium Chloride results in increased abundance of Lithium] which results in increased expression of HMOX1 mRNA
CTD PMID:18619545 PMID:26074776 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Homer3 homer scaffold protein 3 decreases expression ISO Lithium results in decreased expression of HOMER3 mRNA CTD PMID:19949822 NCBI chr16:19,132,177...19,142,739
Ensembl chr16:19,132,162...19,142,680
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression EXP Lithium results in increased expression of HPRT1 protein CTD PMID:18296634 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases expression EXP Lithium results in increased expression of HSD11B2 mRNA; Lithium results in increased expression of HSD11B2 protein CTD PMID:15687245 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 increases expression EXP Lithium results in increased expression of HSD17B10 protein CTD PMID:18296634 NCBI chr  X:21,089,152...21,091,597
Ensembl chr  X:21,089,122...21,109,488
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression EXP Lithium results in increased expression of HSP90B1 mRNA; Lithium results in increased expression of HSP90B1 protein CTD PMID:16236328 PMID:18296634 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression EXP Lithium results in increased expression of HSPA1B protein CTD PMID:18296634 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like decreases expression EXP Lithium results in decreased expression of HSPA1L protein CTD PMID:18296634 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
EXP [Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein; Edaravone promotes the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein]
Lithium results in increased expression of HSPA5 mRNA; Lithium results in increased expression of HSPA5 protein
CTD PMID:16236328 PMID:18296634 PMID:21429313 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression
multiple interactions
EXP Lithium results in increased expression of HSPA9 protein
Lithium inhibits the reaction [Methamphetamine results in increased expression of HSPA9 mRNA]
CTD PMID:18296634 PMID:19149911 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 multiple interactions ISO [Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Dextroamphetamine results in increased expression of IDO1 protein] CTD PMID:31760073 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO Lithium inhibits the reaction [Olanzapine results in decreased expression of IL10 protein]
Lithium results in increased expression of IL10 mRNA
CTD PMID:30695037 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Lithium inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:19159680 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
decreases expression
ISO [Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA]; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein]
Lithium results in increased expression of IL1B protein
Lithium inhibits the reaction [Olanzapine results in increased expression of IL1B mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL1B protein]
Lithium results in decreased expression of IL1B mRNA
CTD PMID:19951488 PMID:30695037 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 increases expression ISO Lithium results in increased expression of IL2 protein CTD PMID:10880530 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions
EXP Lithium results in increased expression of IL4 protein
Lithium inhibits the reaction [Cadmium results in decreased expression of IL4 protein]
CTD PMID:20455018 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO Lithium inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL6 mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL6 protein]
Lithium results in increased expression of IL6 mRNA
CTD PMID:19159680 PMID:30695037 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Impa1 inositol monophosphatase 1 decreases response to substance ISO IMPA1 protein results in decreased susceptibility to Lithium CTD PMID:17460611 NCBI chr 2:91,462,781...91,484,057
Ensembl chr 2:91,462,799...91,484,313
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased expression of JUN protein; Lithium promotes the reaction [Pilocarpine results in increased expression of JUN mRNA] CTD PMID:7984056 PMID:19430551 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Lithium promotes the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7984056 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Kif20a kinesin family member 20A increases expression EXP Lithium results in increased expression of KIF20A mRNA CTD PMID:21711903 NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
JBrowse link
G Kif23 kinesin family member 23 increases expression EXP Lithium results in increased expression of KIF23 mRNA CTD PMID:21711903 NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
JBrowse link
G Kifc1 kinesin family member C1 increases expression EXP Lithium results in increased expression of KIFC1 mRNA CTD PMID:21711903 NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105
JBrowse link
G Klf6 Kruppel-like factor 6 affects expression ISO Lithium affects the expression of KLF6 mRNA CTD PMID:21092101 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Lithium inhibits the reaction [Cadmium results in decreased expression of LHB protein] CTD PMID:20455018 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lmna lamin A/C increases expression EXP Lithium results in increased expression of LMNA protein CTD PMID:18296634 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO [Lithium results in increased phosphorylation of and results in increased activity of MAP3K8 protein] which results in increased phosphorylation of MAP2K1 protein CTD PMID:19159680 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 increases degradation
multiple interactions
ISO Lithium results in increased degradation of MAP3K8 protein alternative form
[Lithium results in increased degradation of NFKB1 protein] inhibits the reaction [NFKB1 protein binds to MAP3K8 protein]; [Lithium results in increased phosphorylation of and results in increased activity of MAP3K8 protein] which results in increased phosphorylation of MAP2K1 protein; Lithium promotes the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP3K8 protein]; Lithium results in increased phosphorylation of and results in increased activity of MAP3K8 protein
CTD PMID:19159680 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression
increases activity
increases phosphorylation
ISO
EXP
Lithium promotes the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Lithium results in increased phosphorylation of and results in increased activity of MAPK1 protein
Lithium results in increased expression of MAPK1 protein
Lithium results in increased activity of MAPK1 protein
Lithium results in increased phosphorylation of MAPK1 protein
CTD PMID:11756416 PMID:18296634 PMID:19159680 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases activity
ISO Lithium promotes the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Lithium results in increased phosphorylation of and results in increased activity of MAPK3 protein
Lithium results in increased activity of MAPK3 protein
CTD PMID:11756416 PMID:19159680 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression
increases phosphorylation
EXP Lithium results in increased expression of MAPK8 protein
Lithium results in increased phosphorylation of MAPK8 protein
CTD PMID:18296634 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression EXP Lithium results in increased expression of MAPK9 protein CTD PMID:18296634 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Lithium inhibits the reaction [Acrolein results in increased phosphorylation of MAPT protein] CTD PMID:12605413 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mir34a microRNA 34a multiple interactions ISO [Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Paraquat results in increased expression of MIR34A mRNA]; [Lithium Chloride results in increased abundance of Lithium] which results in decreased expression of MIR34A mRNA CTD PMID:26074776 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
JBrowse link
G Mir497 microRNA 497 multiple interactions ISO Lithium inhibits the reaction [Ethanol results in increased expression of MIR497] CTD PMID:21878650 NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP Lithium results in increased expression of MKI67 mRNA CTD PMID:21711903 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in increased expression of MRPL18 mRNA] CTD PMID:19149911 NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987
JBrowse link
G Mrpl53 mitochondrial ribosomal protein L53 multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in increased expression of MRPL53 mRNA] CTD PMID:19149911 NCBI chr 4:115,615,329...115,616,219 JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [Lithium results in decreased activity of GSK3B protein] which results in increased activity of MTOR protein CTD PMID:17921520 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myl6 myosin light chain 6 decreases expression EXP Lithium results in decreased expression of MYL6 protein CTD PMID:18296634 NCBI chr 7:910,764...914,062
Ensembl chr 7:910,774...933,791
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity
multiple interactions
ISO Lithium results in increased activity of NFE2L2 protein
[Lithium Chloride results in increased abundance of Lithium] which affects the localization of NFE2L2 protein; [Lithium Chloride results in increased abundance of Lithium] which results in increased expression of NFE2L2 mRNA
[Lithium results in decreased activity of GSK3B protein] which results in increased activity of NFE2L2 protein
CTD PMID:18619545 PMID:26074776 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases degradation
multiple interactions
ISO Lithium results in increased degradation of NFKB1 protein
[Lithium results in increased degradation of NFKB1 protein] inhibits the reaction [NFKB1 protein binds to MAP3K8 protein]; Lithium inhibits the reaction [Lipopolysaccharides results in increased activity of and results in increased localization of NFKB1 protein]
CTD PMID:19159680 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 increases expression EXP Lithium results in increased expression of NME2 protein CTD PMID:18296634 NCBI chr10:78,898,097...78,903,600
Ensembl chr10:78,897,770...78,903,538
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases expression
EXP [Pilocarpine co-treated with Lithium] results in increased expression of NOS1 protein; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS1 protein]
Lithium results in increased expression of NOS1 mRNA
CTD PMID:11087959 PMID:20149694 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP [Pilocarpine co-treated with Lithium] results in increased expression of NOS2 protein; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS2 protein] CTD PMID:20149694 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npy neuropeptide Y increases expression EXP Lithium results in increased expression of NPY mRNA; Lithium results in increased expression of NPY protein CTD PMID:17572454 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Lithium Chloride results in increased abundance of Lithium] which results in increased expression of NQO1 mRNA CTD PMID:26074776 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 affects response to substance ISO NR1D1 gene polymorphism affects the susceptibility to Lithium CTD PMID:20348464 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Lithium inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]]; Lithium inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]
Lithium inhibits the reaction [Dexamethasone affects the localization of and results in increased activity of NR3C1 protein]
CTD PMID:15249158 PMID:15872096 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Lithium results in increased expression of NR4A2 mRNA CTD PMID:21092101 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Nsfl1c NSFL1 cofactor increases expression EXP Lithium results in increased expression of NSFL1C protein CTD PMID:18296634 NCBI chr 3:139,978,306...140,002,876
Ensembl chr 3:139,978,301...140,002,870
JBrowse link
G Ntf3 neurotrophin 3 increases expression
multiple interactions
EXP Lithium results in increased expression of NTF3 protein
Lithium inhibits the reaction [Amphetamine affects the expression of NTF3 protein]
CTD PMID:17512948 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Nudt4 nudix hydrolase 4 increases expression EXP Lithium results in increased expression of NUDT4 mRNA CTD PMID:11331144 NCBI chr 7:30,188,100...30,204,620
Ensembl chr 7:30,188,100...30,204,615
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression ISO Lithium results in decreased expression of OGG1 mRNA CTD PMID:22641096 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide increases secretion
increases expression
EXP Lithium results in increased secretion of OXT protein
Lithium results in increased expression of OXT mRNA
CTD PMID:11739594 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G P2ry4 pyrimidinergic receptor P2Y4 increases expression EXP Lithium results in increased expression of P2RY4 mRNA CTD PMID:19244398 NCBI chr  X:65,681,680...65,717,404
Ensembl chr  X:65,683,232...65,721,748
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Lithium inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] CTD PMID:17849503 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 increases expression ISO Lithium results in increased expression of PARP4 mRNA CTD PMID:19949822 NCBI chr15:30,690,503...30,792,868 JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 increases expression ISO Lithium results in increased expression of PCMT1 mRNA CTD PMID:19949822 NCBI chr 1:2,111,756...2,160,354
Ensembl chr 1:2,111,763...2,159,201
JBrowse link
G Pdcd6 programmed cell death 6 increases expression EXP Lithium results in increased expression of PDCD6 protein CTD PMID:18296634 NCBI chr 1:28,966,518...28,982,188
Ensembl chr 1:28,966,518...28,982,189
JBrowse link
G Pde4a phosphodiesterase 4A decreases expression EXP Lithium results in decreased expression of PDE4A protein CTD PMID:20222156 NCBI chr 8:19,706,649...19,751,937
Ensembl chr 8:19,703,290...19,751,961
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression EXP Lithium results in decreased expression of PDE4B protein CTD PMID:20222156 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pde8b phosphodiesterase 8B decreases expression EXP Lithium results in decreased expression of PDE8B mRNA CTD PMID:20222156 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression EXP Lithium results in increased expression of PDIA3 protein CTD PMID:18296634 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 increases expression EXP Lithium results in increased expression of PEBP1 protein CTD PMID:18296634 NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
JBrowse link
G Pex1 peroxisomal biogenesis factor 1 increases expression ISO Lithium results in increased expression of PEX1 mRNA CTD PMID:19949822 NCBI chr 4:30,519,950...30,558,953
Ensembl chr 4:30,519,955...30,558,921
JBrowse link
G Pgam1 phosphoglycerate mutase 1 increases expression EXP Lithium results in increased expression of PGAM1 protein CTD PMID:18296634 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452
JBrowse link
G Phb prohibitin increases expression EXP Lithium results in increased expression of PHB protein CTD PMID:18296634 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
JBrowse link
G Pla2g4a phospholipase A2 group IVA increases expression ISO Lithium results in increased expression of PLA2G4A mRNA; Lithium results in increased expression of PLA2G4A protein CTD PMID:17594078 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Pls3 plastin 3 increases expression EXP Lithium results in increased expression of PLS3 protein CTD PMID:18296634 NCBI chr  X:111,589,193...111,683,908
Ensembl chr  X:111,589,254...111,683,891
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO [Guanosine Triphosphate co-treated with Lithium] results in decreased activity of POMC protein modified form CTD PMID:2550106 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppia peptidylprolyl isomerase A increases expression EXP Lithium results in increased expression of PPIA protein CTD PMID:18296634 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
JBrowse link
G Prdx5 peroxiredoxin 5 increases expression EXP Lithium results in increased expression of PRDX5 protein CTD PMID:18296634 NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
decreases response to substance
increases response to substance
ISO PRKCA gene mutant form inhibits the reaction [Lithium results in decreased expression of AQP2 protein]; PRKCA gene mutant form inhibits the reaction [Lithium results in decreased expression of SLC14A2 protein]
PRKCA gene mutant form results in decreased susceptibility to Lithium
PRKCA gene results in increased susceptibility to Lithium
CTD PMID:25006961 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in increased expression of PRKCE mRNA] CTD PMID:19149911 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions ISO Lithium inhibits the reaction [PRKCG protein mutant form binds to PRKCG protein mutant form] CTD PMID:20398063 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
G Prl prolactin multiple interactions EXP Lithium inhibits the reaction [Cadmium results in increased expression of PRL protein] CTD PMID:20455018 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Psmb1 proteasome 20S subunit beta 1 increases expression EXP Lithium results in increased expression of PSMB1 protein CTD PMID:18296634 NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 increases expression EXP Lithium results in increased expression of PSMB9 protein CTD PMID:18296634 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
JBrowse link
G Psmd1 proteasome 26S subunit, non-ATPase 1 decreases expression ISO Lithium results in decreased expression of PSMD1 mRNA CTD PMID:19949822 NCBI chr 9:86,709,714...86,785,213
Ensembl chr 9:86,709,947...86,785,211
JBrowse link
G Psmd13 proteasome 26S subunit, non-ATPase 13 increases expression EXP Lithium results in increased expression of PSMD13 protein CTD PMID:18296634 NCBI chr 1:195,964,617...195,976,895
Ensembl chr 1:195,964,138...195,976,905
JBrowse link
G Psmd8 proteasome 26S subunit, non-ATPase 8 increases expression EXP Lithium results in increased expression of PSMD8 protein CTD PMID:18296634 NCBI chr 1:84,474,377...84,481,209
Ensembl chr 1:84,474,378...84,481,209
JBrowse link
G Psme2 proteasome activator subunit 2 increases expression EXP Lithium results in increased expression of PSME2 protein CTD PMID:18296634 NCBI chr15:29,078,495...29,082,794
Ensembl chr15:29,078,500...29,082,946
JBrowse link
G Pth parathyroid hormone increases expression EXP
ISO
Lithium results in increased expression of PTH protein CTD PMID:581022 PMID:7212107 PMID:8840263 PMID:10423626 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased activity of PTK2B protein CTD PMID:16600505 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in decreased expression of QARS1 mRNA] CTD PMID:19149911 NCBI chr 8:109,207,705...109,215,738
Ensembl chr 8:109,207,705...109,215,739
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 increases expression EXP Lithium results in increased expression of RACGAP1 mRNA CTD PMID:21711903 NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831
JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase decreases expression ISO Lithium results in decreased expression of RAD18 mRNA CTD PMID:22641096 NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069
JBrowse link
G Ran RAN, member RAS oncogene family increases expression EXP Lithium results in increased expression of RAN protein CTD PMID:18296634 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO Lithium promotes the reaction [Lipopolysaccharides results in increased localization of REL protein] CTD PMID:19159680 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
ISO Lithium inhibits the reaction [Lipopolysaccharides results in increased activity of and results in increased localization of RELA protein]
Lithium results in increased activity of RELA protein
CTD PMID:11756416 PMID:19159680 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Reln reelin decreases expression EXP Lithium results in decreased expression of RELN mRNA; Lithium results in decreased expression of RELN protein CTD PMID:19359144 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Ret ret proto-oncogene multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased expression of RET protein CTD PMID:12914250 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
JBrowse link
G Rgcc regulator of cell cycle increases expression ISO Lithium results in increased expression of RGCC mRNA CTD PMID:21092101 NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO Lithium results in increased expression of RGS2 mRNA CTD PMID:21092101 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Rnmt RNA (guanine-7-) methyltransferase increases expression ISO Lithium results in increased expression of RNMT mRNA CTD PMID:19949822 NCBI chr18:61,886,230...61,909,775
Ensembl chr18:61,886,292...61,909,775
JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression EXP Lithium results in decreased expression of S100A4 protein CTD PMID:18296634 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression EXP Lithium results in decreased expression of S100A6 protein CTD PMID:18296634 NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha multiple interactions ISO [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Lithium CTD PMID:18665318 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta multiple interactions ISO [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Lithium CTD PMID:18665318 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma affects expression
multiple interactions
EXP
ISO
Lithium affects the expression of SCNN1G protein
[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Lithium
CTD PMID:12928314 PMID:18665318 NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816
JBrowse link
G Slc12a1 solute carrier family 12 member 1 increases expression EXP Lithium results in increased expression of SLC12A1 mRNA; Lithium results in increased expression of SLC12A1 protein CTD PMID:10966935 PMID:12472779 NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899
JBrowse link
G Slc13a2 solute carrier family 13 member 2 multiple interactions ISO
EXP
Lithium inhibits the reaction [SLC13A2 protein results in increased uptake of Citric Acid]
Lithium promotes the reaction [SLC13A2 protein results in increased uptake of Citric Acid]
CTD PMID:12826022 NCBI chr10:63,291,813...63,319,127
Ensembl chr10:63,291,815...63,319,127
JBrowse link
G Slc14a2 solute carrier family 14 member 2 decreases expression
multiple interactions
ISO Lithium results in decreased expression of SLC14A2 protein
PRKCA gene mutant form inhibits the reaction [Lithium results in decreased expression of SLC14A2 protein]
CTD PMID:25006961 NCBI chr18:71,612,460...72,039,462
Ensembl chr18:71,612,460...71,792,968
JBrowse link
G Slc17a6 solute carrier family 17 member 6 increases expression ISO Lithium results in increased expression of SLC17A6 mRNA; Lithium results in increased expression of SLC17A6 protein CTD PMID:18155072 NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542
JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression ISO Lithium results in increased expression of SLC17A7 mRNA; Lithium results in increased expression of SLC17A7 protein CTD PMID:16111724 NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
JBrowse link
G Slc20a1 solute carrier family 20 member 1 multiple interactions ISO Lithium promotes the reaction [SLC20A1 protein results in increased uptake of Phosphates] CTD PMID:17494632 NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051
JBrowse link
G Slc20a2 solute carrier family 20 member 2 multiple interactions ISO Lithium promotes the reaction [SLC20A2 protein results in increased uptake of Phosphates] CTD PMID:17494632 NCBI chr16:69,460,850...69,551,418
Ensembl chr16:69,460,462...69,521,711
JBrowse link
G Slc9a1 solute carrier family 9 member A1 decreases expression
increases activity
multiple interactions
ISO Lithium results in decreased expression of SLC9A1 mRNA
Lithium results in increased activity of SLC9A1 protein
Phloretin inhibits the reaction [SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]]; SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]
CTD PMID:12765964 PMID:18506424 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
JBrowse link
G Slc9a3 solute carrier family 9 member A3 increases expression EXP Lithium results in increased expression of SLC9A3 protein CTD PMID:10966935 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417
JBrowse link
G Slc9b2 solute carrier family 9 member B2 multiple interactions ISO SLC9B2 protein affects the transport of [Sodium co-treated with Lithium] CTD PMID:18000046 NCBI chr 2:223,726,982...223,761,234
Ensembl chr 2:223,736,354...223,761,225
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression EXP Lithium results in decreased expression of SLCO1A4 mRNA CTD PMID:19570321 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slit2 slit guidance ligand 2 increases expression
decreases expression
EXP Lithium results in increased expression of SLIT2 protein
Lithium results in decreased expression of SLIT2 protein
CTD PMID:20153733 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948
JBrowse link
G Snca synuclein alpha multiple interactions EXP Lithium inhibits the reaction [Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein] CTD PMID:25433145 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
EXP Lithium inhibits the reaction [Cadmium results in decreased expression of SOD1 protein]
Lithium results in increased expression of SOD1 protein
CTD PMID:18296634 PMID:20455018 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Dextroamphetamine results in decreased activity of SOD2 protein] CTD PMID:31760073 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sparcl1 SPARC like 1 affects localization EXP Lithium affects the localization of SPARCL1 protein CTD PMID:18488994 NCBI chr14:5,632,816...5,663,866
Ensembl chr14:5,632,569...5,663,865
JBrowse link
G Spc25 SPC25 component of NDC80 kinetochore complex increases expression EXP Lithium results in increased expression of SPC25 mRNA CTD PMID:21711903 NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased activity of SRC protein CTD PMID:16600505 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 increases expression EXP Lithium results in increased expression of SRCIN1 protein CTD PMID:18296634 NCBI chr10:82,511,101...82,568,706
Ensembl chr10:82,504,393...82,571,040
JBrowse link
G Stc2 stanniocalcin 2 decreases expression ISO Lithium results in decreased expression of STC2 mRNA CTD PMID:21092101 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Stip1 stress-induced phosphoprotein 1 increases expression EXP Lithium results in increased expression of STIP1 protein CTD PMID:18296634 NCBI chr 1:204,209,434...204,228,452
Ensembl chr 1:204,178,932...204,228,476
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression ISO Lithium results in decreased expression of SULT1A1 mRNA CTD PMID:19949822 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP [Pilocarpine co-treated with Lithium] results in increased expression of TAC1 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of TAC1 protein modified form; Dizocilpine Maleate inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of TAC1 protein modified form] CTD PMID:11074153 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Lithium inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:19149911 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP Lithium results in decreased expression of TJP1 protein CTD PMID:17533168 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tkt transketolase increases expression EXP Lithium results in increased expression of TKT protein CTD PMID:18296634 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
G Tmx4 thioredoxin-related transmembrane protein 4 increases expression EXP Lithium results in increased expression of TMX4 protein CTD PMID:18296634 NCBI chr 3:121,856,237...121,899,680
Ensembl chr 3:121,856,261...121,899,641
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
Lithium inhibits the reaction [Cadmium results in increased expression of TNF protein]
Lithium inhibits the reaction [Olanzapine results in increased expression of TNF mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of TNF protein]
Lithium results in decreased expression of TNF mRNA
CTD PMID:20455018 PMID:30695037 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top2a DNA topoisomerase II alpha increases expression EXP Lithium results in increased expression of TOP2A mRNA CTD PMID:21711903 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO TP53 affects the reaction [Lithium results in increased expression of CDKN1A protein]
Lithium inhibits the reaction [GSK3B protein binds to TP53 protein]; Lithium inhibits the reaction [sodium arsenite results in increased expression of and affects the localization of TP53 protein]
CTD PMID:11337498 PMID:15475000 PMID:17849503 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP Lithium results in increased expression of TPI1 protein CTD PMID:18296634 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
JBrowse link
G Tpm1 tropomyosin 1 decreases expression EXP Lithium results in decreased expression of TPM1 protein CTD PMID:18296634 NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases transport ISO TRPC6 protein results in increased transport of Lithium CTD PMID:11179201 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions ISO Lithium inhibits the reaction [Monensin results in increased expression of TRPM2 protein alternative form] CTD PMID:20799912 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions ISO [Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA] CTD PMID:29957541 NCBI chr  X:104,217,898...104,277,935
Ensembl chr  X:104,217,925...104,276,861
JBrowse link
G Ttk Ttk protein kinase increases expression EXP Lithium results in increased expression of TTK mRNA CTD PMID:21711903 NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C increases expression EXP Lithium results in increased expression of UBE2C mRNA CTD PMID:21711903 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Uck1 uridine-cytidine kinase 1 increases expression EXP Lithium results in increased expression of UCK1 protein CTD PMID:18296634 NCBI chr 3:15,538,580...15,544,465
Ensembl chr 3:15,538,591...15,544,465
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase multiple interactions ISO [Lithium Chloride results in increased abundance of Lithium] which results in increased expression of UGCG mRNA CTD PMID:26074776 NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 increases expression EXP Lithium results in increased expression of UHRF1 mRNA CTD PMID:21711903 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 increases expression EXP Lithium results in increased expression of UQCRFS1 protein CTD PMID:18296634 NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
decreases expression
EXP
ISO
Lithium results in increased expression of VEGFA mRNA; Lithium results in increased expression of VEGFA protein
Lithium results in decreased expression of VEGFA mRNA
CTD PMID:16288908 PMID:17533168 PMID:19949822 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vps29 VPS29 retromer complex component increases expression EXP Lithium results in increased expression of VPS29 protein CTD PMID:18296634 NCBI chr12:34,208,911...34,217,977
Ensembl chr12:34,207,263...34,217,964
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon increases expression EXP Lithium results in increased expression of YWHAE protein CTD PMID:18296634 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta decreases expression EXP Lithium results in decreased expression of YWHAQ protein CTD PMID:18296634 NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273
JBrowse link
tetraethyllead term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP Tetraethyl Lead results in decreased activity of ACHE protein CTD PMID:14631503 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Plat plasminogen activator, tissue type affects activity EXP Tetraethyl Lead affects the activity of PLAT protein CTD PMID:2143947 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plg plasminogen affects activity EXP Tetraethyl Lead affects the activity of PLG protein modified form CTD PMID:2143947 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
trimethyltin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 increases expression
multiple interactions
ISO trimethyltin results in increased expression of AIF1 mRNA; trimethyltin results in increased expression of AIF1 protein
magnolol inhibits the reaction [trimethyltin results in increased expression of AIF1 protein]
CTD PMID:24002884 PMID:26756313 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Arg1 arginase 1 multiple interactions EXP [trimethyltin chloride results in increased abundance of trimethyltin] which results in decreased expression of ARG1 mRNA CTD PMID:30993381 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO trimethyltin results in increased expression of ATF3 mRNA CTD PMID:24002884 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form]]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form] CTD PMID:25895139 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]]; magnolol inhibits the reaction [trimethyltin results in increased expression of BAX protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein] CTD PMID:25895139 PMID:26756313 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]]; magnolol inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein] CTD PMID:25895139 PMID:26756313 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein] CTD PMID:25895139 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G C1qa complement C1q A chain increases expression ISO trimethyltin results in increased expression of C1QA mRNA CTD PMID:21435392 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C1qb complement C1q B chain increases expression ISO trimethyltin results in increased expression of C1QB mRNA CTD PMID:21435392 PMID:24002884 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]]; HR protein affects the reaction [trimethyltin results in increased activity of CASP3 protein]; magnolol inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]; rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]
trimethyltin results in increased expression of CASP3 mRNA; trimethyltin results in increased expression of CASP3 protein modified form
CTD PMID:20886113 PMID:21435392 PMID:22634143 PMID:24002884 PMID:25895139 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO trimethyltin results in increased expression of CCL2 mRNA CTD PMID:21435392 PMID:24002884 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO trimethyltin results in increased expression of CCL3 mRNA CTD PMID:21435392 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO trimethyltin results in increased expression of CCL4 mRNA CTD PMID:24002884 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO trimethyltin results in increased expression of CD44 mRNA CTD PMID:24002884 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cd86 CD86 molecule multiple interactions EXP [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of CD86 mRNA CTD PMID:30993381 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO trimethyltin results in increased expression of CFLAR mRNA CTD PMID:21435392 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex increases expression ISO trimethyltin results in increased expression of CHUK mRNA CTD PMID:21435392 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of CXCL1 mRNA CTD PMID:30993381 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cycs cytochrome c, somatic decreases expression ISO trimethyltin results in decreased expression of CYCS mRNA CTD PMID:21435392 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
multiple interactions
EXP trimethyltin results in decreased expression of CYP11A1 mRNA
trimethyltin results in decreased expression of and results in decreased activity of CYP11A1 protein
CTD PMID:32898603 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO trimethyltin results in increased expression of FAS mRNA CTD PMID:24002884 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression ISO trimethyltin results in increased expression of FASL mRNA CTD PMID:24002884 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression ISO trimethyltin results in increased expression of FGF21 mRNA CTD PMID:24002884 NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO trimethyltin results in increased expression of GCLC mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]
CTD PMID:25895139 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA] CTD PMID:25895139 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gfap glial fibrillary acidic protein increases expression
multiple interactions
ISO trimethyltin results in increased expression of GFAP mRNA; trimethyltin results in increased expression of GFAP protein
magnolol inhibits the reaction [trimethyltin results in increased expression of GFAP protein]
CTD PMID:24002884 PMID:26756313 PMID:27729293 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Grb2 growth factor receptor bound protein 2 increases expression ISO trimethyltin results in increased expression of GRB2 mRNA CTD PMID:20833246 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression ISO trimethyltin results in decreased expression of GRIN2B mRNA CTD PMID:24002884 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grm3 glutamate metabotropic receptor 3 decreases expression ISO trimethyltin results in decreased expression of GRM3 mRNA CTD PMID:24002884 NCBI chr 4:24,364,854...24,643,972
Ensembl chr 4:24,365,115...24,609,804
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO trimethyltin results in increased expression of HIF1A mRNA CTD PMID:24002884 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO trimethyltin results in increased expression of HMOX1 protein
trimethyltin results in increased expression of HMOX1 mRNA
magnolol inhibits the reaction [trimethyltin results in increased expression of HMOX1 protein]
CTD PMID:26756313 PMID:27729293 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor affects response to substance
multiple interactions
ISO HR protein affects the susceptibility to trimethyltin
HR protein affects the reaction [trimethyltin results in increased activity of CASP3 protein]
CTD PMID:20886113 NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313
JBrowse link
G Hras HRas proto-oncogene, GTPase increases expression ISO trimethyltin results in increased expression of HRAS mRNA CTD PMID:21435392 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions ISO
EXP
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; [[trimethyltin chloride results in increased abundance of trimethyltin] which co-treated with Corticosterone] results in increased expression of HSD11B1 mRNA; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased activity of HSD11B1 protein; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA; Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; LY 290042 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; Mifepristone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]
[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA; Cortisone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; INS protein affects the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]
CTD PMID:30993381 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression
EXP trimethyltin results in decreased expression of and results in decreased activity of HSD17B3 protein
trimethyltin results in decreased expression of HSD17B3 mRNA
CTD PMID:32898603 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
JBrowse link
G Ifng interferon gamma increases expression ISO trimethyltin results in increased expression of IFNG mRNA CTD PMID:24002884 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO trimethyltin results in increased expression of IGF1 mRNA CTD PMID:21435392 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il10 interleukin 10 increases expression ISO trimethyltin results in increased expression of IL10 mRNA CTD PMID:24002884 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO trimethyltin results in increased expression of IL1A mRNA CTD PMID:20833246 PMID:21435392 PMID:24002884 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1r1 interleukin 1 receptor type 1 increases expression ISO trimethyltin results in increased expression of IL1R1 mRNA CTD PMID:20833246 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO trimethyltin results in increased expression of IL1RN mRNA CTD PMID:21435392 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
decreases expression
decreases response to substance
ISO
EXP
trimethyltin results in increased expression of IL6 mRNA; trimethyltin results in increased expression of IL6 protein
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; 11-dehydrocorticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased secretion of IL6 protein; Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Dexamethasone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; INS1 protein inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; LY 290042 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Resveratrol analog inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]]
trimethyltin results in decreased expression of IL6 mRNA
IL6 results in decreased susceptibility to trimethyltin
CTD PMID:20833246 PMID:21435392 PMID:24002884 PMID:30993381 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor increases expression ISO trimethyltin results in increased expression of IL6RA protein CTD PMID:21435392 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer increases expression ISO trimethyltin results in increased expression of IL6ST mRNA CTD PMID:20833246 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
JBrowse link
G Ins2 insulin 2 multiple interactions EXP [trimethyltin chloride results in increased abundance of trimethyltin] promotes the reaction [INS protein affects the expression of NEFH mRNA]; INS protein affects the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA] CTD PMID:30993381 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions
ISO
EXP
trimethyltin results in increased expression of ITGAM mRNA
[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of ITGAM mRNA
CTD PMID:24002884 PMID:30993381 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Jak1 Janus kinase 1 increases expression ISO trimethyltin results in increased expression of JAK1 mRNA CTD PMID:20833246 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO trimethyltin results in increased expression of JUN mRNA CTD PMID:21435392 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO trimethyltin results in increased expression of LCN2 mRNA CTD PMID:24002884 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lynx1 Ly6/neurotoxin 1 decreases expression ISO trimethyltin results in decreased expression of LYNX1 mRNA CTD PMID:24002884 NCBI chr 7:106,632,800...106,638,003
Ensembl chr 7:106,632,797...106,638,023
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases degradation EXP trimethyltin results in decreased degradation of MAP1LC3B protein modified form CTD PMID:26459185 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression ISO trimethyltin results in increased expression of MAP2K1 mRNA CTD PMID:20833246 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 decreases expression ISO trimethyltin results in decreased expression of MAP2K6 mRNA CTD PMID:21435392 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression ISO trimethyltin results in increased expression of MAPK1 mRNA CTD PMID:20833246 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO trimethyltin results in increased expression of MAPK3 mRNA CTD PMID:20833246 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO trimethyltin results in increased phosphorylation of MAPK8 protein
magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of MAPK8 protein]
CTD PMID:26756313 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
ISO magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of MAPK9 protein] CTD PMID:26756313 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression ISO trimethyltin results in increased expression of MKI67 mRNA CTD PMID:24002884 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions EXP [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of MRC1 mRNA CTD PMID:30993381 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression ISO trimethyltin results in increased expression of MYD88 mRNA CTD PMID:21435392 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nefh neurofilament heavy chain multiple interactions EXP [trimethyltin chloride results in increased abundance of trimethyltin] promotes the reaction [INS protein affects the expression of NEFH mRNA] CTD PMID:30993381 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]]; rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]; trimethyltin affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:25895139 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation
ISO magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of NFKBIA protein] CTD PMID:26756313 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA]; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA; magnolol inhibits the reaction [trimethyltin results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA] CTD PMID:26756313 PMID:30993381 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression EXP trimethyltin results in decreased expression of NR5A1 mRNA; trimethyltin results in decreased expression of NR5A1 protein CTD PMID:32898603 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328
JBrowse link
G Ntf3 neurotrophin 3 decreases expression ISO trimethyltin results in decreased expression of NTF3 mRNA CTD PMID:24002884 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 decreases expression ISO trimethyltin results in decreased expression of NTRK3 mRNA CTD PMID:24002884 NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO rottlerin inhibits the reaction [trimethyltin results in increased expression of and results in increased cleavage of PRKCD protein]; trimethyltin results in increased expression of and results in increased cleavage of PRKCD protein CTD PMID:25895139 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 increases expression ISO trimethyltin results in increased expression of PTPN11 mRNA CTD PMID:21435392 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 increases expression ISO trimethyltin results in increased expression of PTPN6 mRNA CTD PMID:20833246 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
JBrowse link
G Rac1 Rac family small GTPase 1 increases expression ISO trimethyltin results in increased expression of RAC1 mRNA CTD PMID:20833246 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression ISO trimethyltin results in increased expression of RAF1 mRNA CTD PMID:20833246 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [trimethyltin chloride results in increased abundance of trimethyltin] which affects the localization of RELA protein; Resveratrol analog inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which affects the localization of RELA protein] CTD PMID:30993381 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rras2 RAS related 2 increases expression ISO trimethyltin results in increased expression of RRAS2 mRNA CTD PMID:20833246 NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111
JBrowse link
G Shc1 SHC adaptor protein 1 increases expression ISO trimethyltin results in increased expression of SHC1 mRNA CTD PMID:20833246 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 increases expression ISO trimethyltin results in increased expression of SOS1 mRNA CTD PMID:20833246 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO trimethyltin results in increased expression of SPP1 mRNA CTD PMID:24002884 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sqstm1 sequestosome 1 decreases degradation EXP trimethyltin results in decreased degradation of SQSTM1 protein CTD PMID:26459185 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srf serum response factor decreases expression ISO trimethyltin results in decreased expression of SRF mRNA CTD PMID:21435392 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP trimethyltin results in decreased expression of STAR mRNA; trimethyltin results in decreased expression of STAR protein CTD PMID:32898603 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO trimethyltin results in increased expression of STAT3 mRNA; trimethyltin results in increased expression of STAT3 protein CTD PMID:21435392 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO trimethyltin results in increased expression of TGFB1 mRNA CTD PMID:21435392 PMID:24002884 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion
ISO
EXP
trimethyltin results in increased expression of TNF mRNA
[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of TNF mRNA
magnolol inhibits the reaction [trimethyltin results in increased secretion of TNF protein]
CTD PMID:21435392 PMID:24002884 PMID:26756313 PMID:30993381 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO trimethyltin results in increased expression of TNFAIP3 mRNA CTD PMID:24002884 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO trimethyltin results in increased expression of TNFRSF1A mRNA CTD PMID:21435392 PMID:24002884 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO trimethyltin results in increased expression of TNFRSF25 mRNA CTD PMID:21435392 NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
JBrowse link
G Tollip toll interacting protein increases expression ISO trimethyltin results in increased expression of TOLLIP mRNA CTD PMID:21435392 NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:196,950,771...196,983,625
JBrowse link
G Tp53 tumor protein p53 increases activity ISO trimethyltin results in increased activity of TRP53 protein CTD PMID:22634143 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      molecular entity 19819
        inorganic molecular entity 19521
          inorganic hydride 17691
            metal hydride 321
              alkali metal hydride + 249
              alkaline earth hydride + 5
              aluminium hydride + 0
              lead hydride + 3
              tin hydride + 88
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              metal hydride 321
                                alkali metal hydride + 249
                                alkaline earth hydride + 5
                                aluminium hydride + 0
                                lead hydride + 3
                                tin hydride + 88
paths to the root