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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:indolocarbazole alkaloid
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Accession:CHEBI:37697 term browser browse the term
Synonyms:related_synonym: indolocarbazole alkaloids;   indolocarbazoles


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midostaurin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO midostaurin results in decreased activity of ABCB1 protein CTD PMID:11836167 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Agt angiotensinogen multiple interactions EXP midostaurin inhibits the reaction [AGT protein results in increased abundance of Epoprostenol] CTD PMID:14613874 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
decreases activity		 ISO midostaurin inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; midostaurin inhibits the reaction [AKR1C3 protein results in increased metabolism of Daunorubicin]
midostaurin results in decreased activity of AKR1C3 protein		 CTD PMID:33025066 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO midostaurin promotes the reaction [Loratadine results in increased activity of CASP3 protein]; midostaurin promotes the reaction [Terfenadine results in increased activity of CASP3 protein] CTD PMID:20570632 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO midostaurin inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]] CTD PMID:15542774 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases activity ISO midostaurin results in decreased activity of FGFR3 protein CTD PMID:16091734 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases response to substance
decreases activity		 ISO FLT3 protein results in decreased susceptibility to midostaurin
midostaurin results in decreased activity of FLT3 protein		 CTD PMID:21980431 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Gypa glycophorin A decreases expression ISO midostaurin results in decreased expression of GYPA protein CTD PMID:19573588 NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO midostaurin inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein] CTD PMID:17420286 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO midostaurin results in increased expression of and results in increased localization of ITGB3 protein CTD PMID:19573588 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO midostaurin inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein] CTD PMID:17420286 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO midostaurin affects the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein] CTD PMID:15542774 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO midostaurin affects the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein] CTD PMID:15542774 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor increases expression ISO midostaurin results in increased expression of MPL protein CTD PMID:19573588 NCBI chr 5:131,973,895...131,987,472
Ensembl chr 5:131,973,895...131,986,797 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP midostaurin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:14613874 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO midostaurin affects the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]; midostaurin inhibits the reaction [EGF protein inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]] CTD PMID:15542774 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
staurosporine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Staurosporine results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Ache acetylcholinesterase multiple interactions
increases expression
increases activity		 ISO ACHE protein affects the susceptibility to [Staurosporine results in increased activity of CASP9 protein]
Staurosporine results in increased expression of ACHE protein alternative form
Staurosporine results in increased activity of ACHE protein		 CTD PMID:20338155 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Adm adrenomedullin decreases expression ISO Staurosporine results in decreased expression of ADM mRNA CTD PMID:19253104 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
Staurosporine results in increased phosphorylation of AKT1 protein
Staurosporine promotes the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]		 CTD PMID:11306697 PMID:15177934 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Staurosporine inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; Staurosporine promotes the reaction [PSEN2 protein mutant form results in increased expression of APP protein] CTD PMID:12556443 PMID:18001288 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ar androgen receptor multiple interactions ISO Staurosporine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atg12 autophagy related 12 affects response to substance ISO ATG12 protein affects the susceptibility to Staurosporine CTD PMID:16497721 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Atg7 autophagy related 7 affects response to substance ISO ATG7 protein affects the susceptibility to Staurosporine CTD PMID:16497721 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression EXP Staurosporine results in decreased expression of ATP2A2 mRNA CTD PMID:10625299 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Bag3 BAG cochaperone 3 decreases response to substance
decreases expression
multiple interactions		 ISO BAG3 protein results in decreased susceptibility to Staurosporine
Staurosporine results in decreased expression of BAG3 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Staurosporine results in increased degradation of BAG3 protein]; Staurosporine results in increased degradation of and results in increased ubiquitination of BAG3 protein		 CTD PMID:19352495 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858 		JBrowse link
G Bag4 BAG cochaperone 4 decreases expression ISO Staurosporine results in decreased expression of BAG4 protein CTD PMID:19352495 NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663 		JBrowse link
G Bag6 BAG cochaperone 6 decreases expression ISO Staurosporine results in decreased expression of BAG6 protein CTD PMID:19352495 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects localization
affects expression
increases expression		 ISO
EXP		 Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in increased expression of BAX protein]]; Staurosporine affects the folding of and results in increased activity of BAX protein; Staurosporine promotes the reaction [Acetaldehyde results in increased expression of BAX protein]; Staurosporine promotes the reaction [BID protein binds to BAX protein]; Staurosporine results in increased activity of and results in increased expression of BAX protein
Staurosporine affects the localization of BAX protein
Staurosporine affects the expression of BAX mRNA
Tacrine inhibits the reaction [Staurosporine results in increased expression of BAX protein]		 CTD PMID:11296547 PMID:12579951 PMID:15961378 PMID:16007140 PMID:19552762 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in decreased expression of BCL2 protein]]; Staurosporine inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Staurosporine promotes the reaction [Acetaldehyde results in decreased expression of BCL2 protein] CTD PMID:15907805 PMID:35158046 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance
increases expression
affects expression		 ISO
EXP		 BCL2L1 protein results in decreased susceptibility to Staurosporine
Staurosporine results in increased expression of BCL2L1 protein alternative form
Staurosporine affects the expression of BCL2L1 mRNA
BCL2L1 gene mutant form results in decreased susceptibility to Staurosporine		 CTD PMID:10679475 PMID:10970895 PMID:11296547 PMID:11468182 PMID:21256112 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 multiple interactions
decreases response to substance		 ISO 3-methyladenine inhibits the reaction [BECN1 protein results in decreased susceptibility to Staurosporine] CTD PMID:16497721 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression
multiple interactions		 ISO Staurosporine results in increased expression of BID protein
Staurosporine promotes the reaction [BID protein binds to BAX protein]		 CTD PMID:19552762 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases response to substance ISO BIRC3 protein results in decreased susceptibility to Staurosporine CTD PMID:16144937 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Staurosporine results in decreased expression of BIRC5 protein CTD PMID:16225760 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B affects expression ISO Staurosporine affects the expression of BUB1B mRNA CTD PMID:15721199 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547 		JBrowse link
G Casp1 caspase 1 multiple interactions
increases activity
affects localization		 ISO Nicotine affects the reaction [Staurosporine affects the localization of CASP1 protein]; Nicotine inhibits the reaction [Staurosporine results in increased activity of CASP1 protein] CTD PMID:16927020 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp2 caspase 2 increases cleavage ISO Staurosporine results in increased cleavage of CASP2 protein CTD PMID:10663630 PMID:26124276 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
increases secretion
increases activity		 ISO
EXP		 Acetaminophen promotes the reaction [Staurosporine results in increased activity of CASP3 protein]; DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP3 protein modified form]; ginkgolide B inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Memantine inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]; PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Rifampin inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Staurosporine results in increased cleavage of and results in increased activity of CASP3 protein; Thiopental inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Valproic Acid inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]
Staurosporine results in increased secretion of CASP3 protein
3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP3 protein]; EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; HR protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Ibuprofen inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; nimesulide inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]
HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]; Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]; TRP53 protein affects the reaction [HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]]; VASP mutant form promotes the reaction [Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]]		 CTD PMID:10663630 PMID:11296547 PMID:12556443 PMID:12871656 PMID:15909127 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 increases cleavage ISO Staurosporine results in increased cleavage of CASP6 protein CTD PMID:26124276 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases expression
increases cleavage
increases activity		 EXP
ISO		 EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]; IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]
Staurosporine results in increased expression of CASP7 protein modified form
Staurosporine results in increased cleavage of CASP7 protein
DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]; ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP7 protein modified form]		 CTD PMID:16402917 PMID:18832097 PMID:19352495 PMID:19406941 PMID:21864672 More... NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
increases activity		 ISO benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Staurosporine results in increased cleavage of CASP8 protein]; Staurosporine results in increased cleavage of and results in increased activity of CASP8 protein
Staurosporine results in increased activity of CASP8 protein		 CTD PMID:16007152 PMID:19352495 PMID:24658017 PMID:29458164 PMID:31926150 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases activity		 ISO
EXP		 ACHE protein affects the susceptibility to [Staurosporine results in increased activity of CASP9 protein]; Staurosporine results in increased cleavage of and results in increased activity of CASP9 protein
Staurosporine results in increased cleavage of CASP9 protein
3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP9 protein]; Sirolimus inhibits the reaction [Staurosporine results in increased cleavage of CASP9 protein]		 CTD PMID:16007152 PMID:16497721 PMID:19352495 PMID:20338155 PMID:26124276 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions EXP Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of and affects the localization of CCR5 protein] CTD PMID:12594210 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd28 Cd28 molecule multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD28 protein] CTD PMID:11465111 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cdc42 cell division cycle 42 multiple interactions EXP Staurosporine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]] CTD PMID:2153673 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDKN1A protein] CTD PMID:15978937 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Staurosporine inhibits the reaction [Tretinoin results in increased phosphorylation of CDKN1B protein] CTD PMID:16618747 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions
affects binding		 ISO Staurosporine affects the reaction [KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]]; Staurosporine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]; Staurosporine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]
Staurosporine binds to CHRM1 protein		 CTD PMID:10860942 PMID:16439611 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO Staurosporine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:10860942 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding EXP Staurosporine binds to CHRM3 protein CTD PMID:12435818 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Staurosporine inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP Staurosporine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]] CTD PMID:2153673 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO CSF2 protein affects the susceptibility to [Nitroblue Tetrazolium co-treated with Staurosporine] CTD PMID:8471626 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csn2 casein beta multiple interactions ISO Staurosporine inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA] CTD PMID:7648427 NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 multiple interactions ISO Staurosporine affects the reaction [Formaldehyde affects the phosphorylation of CSNK2A1 protein] CTD PMID:36534342 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 affects expression ISO Staurosporine affects the expression of CSNK2A2 mRNA CTD PMID:15721199 NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080 		JBrowse link
G Ctnnb1 catenin beta 1 increases phosphorylation EXP Staurosporine results in increased phosphorylation of CTNNB1 protein CTD PMID:19741129 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions EXP Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of and affects the localization of CCR5 protein]; Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of CXCR4 protein] CTD PMID:12594210 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions EXP Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of CXCR4 protein] CTD PMID:12594210 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of CYBB protein] CTD PMID:29183754 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP		 Staurosporine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Staurosporine inhibits the reaction [benz(a)anthracene results in increased activity of CYP1A1 protein]; Staurosporine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Staurosporine inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]		 CTD PMID:1312672 PMID:7587946 PMID:9395520 PMID:10696073 PMID:15947024 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression		 EXP Staurosporine inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]
Staurosporine results in increased expression of CYP2E1 mRNA		 CTD PMID:11306697 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Staurosporine inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] CTD PMID:17965521 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Staurosporine results in increased expression of DDIT3 mRNA CTD PMID:32870474 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dedd death effector domain-containing affects expression ISO Staurosporine affects the expression of DEDD mRNA CTD PMID:15721199 NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332 		JBrowse link
G Dock1 dedicator of cyto-kinesis 1 multiple interactions ISO DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein] CTD PMID:25586182 NCBI chr 1:189,467,143...189,983,777
Ensembl chr 1:189,467,143...189,983,768 		JBrowse link
G Edf1 endothelial differentiation-related factor 1 multiple interactions
decreases expression		 EXP Staurosporine inhibits the reaction [MBF1 protein results in increased secretion of NPPA protein]
Staurosporine results in decreased expression of MBF1 protein		 CTD PMID:12729799 NCBI chr 3:8,377,058...8,381,363
Ensembl chr 3:8,366,613...8,381,363 		JBrowse link
G Edn1 endothelin 1 decreases activity EXP Staurosporine results in decreased activity of EDN1 protein CTD PMID:15464066 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP Staurosporine inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]; Staurosporine inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein] CTD PMID:20561571 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO
EXP		 Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]
EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]		 CTD PMID:15542774 PMID:19406941 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:15177934 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases activity ISO Staurosporine results in decreased activity of EIF2AK2 protein CTD PMID:12890478 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Staurosporine results in increased phosphorylation of EIF2S1 protein CTD PMID:21090173 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Elmo1 engulfment and cell motility 1 multiple interactions ISO ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein] CTD PMID:25586182 NCBI chr17:44,286,495...44,822,668
Ensembl chr17:44,286,485...44,822,788 		JBrowse link
G Eomes eomesodermin multiple interactions ISO EOMES protein inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP3 protein modified form]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP7 protein modified form] CTD PMID:27539959 NCBI chr 8:118,181,340...118,189,186
Ensembl chr 8:118,181,777...118,188,316 		JBrowse link
G Epo erythropoietin decreases response to substance
multiple interactions		 EXP EPO protein results in decreased susceptibility to Staurosporine
tin mesoporphyrin inhibits the reaction [EPO protein results in decreased susceptibility to Staurosporine]		 CTD PMID:15816862 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease affects expression ISO Staurosporine affects the expression of ERCC5 mRNA CTD PMID:15721199 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Staurosporine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Staurosporine binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Staurosporine inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA] CTD PMID:15371228 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fermt2 FERM domain containing kindlin 2 affects expression ISO Staurosporine affects the expression of FERMT2 mRNA CTD PMID:15721199 NCBI chr15:18,682,927...18,751,959
Ensembl chr15:18,682,927...18,751,811 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Staurosporine inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] CTD PMID:7945571 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Staurosporine inhibits the reaction [Acetaldehyde results in increased expression of FOS mRNA]; Staurosporine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA] CTD PMID:7945571 PMID:9417049 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Staurosporine promotes the reaction [MYC protein binds to GCLC promoter] CTD PMID:17628013 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO Staurosporine promotes the reaction [MYC protein binds to GCLM promoter] CTD PMID:17628013 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] CTD PMID:21879721 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO Staurosporine promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates] CTD PMID:18313772 NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions EXP Staurosporine inhibits the reaction [benz(a)anthracene results in increased activity of GSTA2 protein] CTD PMID:7587946 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Staurosporine inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Staurosporine inhibits the reaction [Smoke analog results in increased expression of HMOX1 protein]; Staurosporine inhibits the reaction [VEGFA protein results in increased expression of HMOX1 protein]
Staurosporine results in increased expression of HMOX1 protein
SOD2 mutant form inhibits the reaction [Staurosporine results in increased expression of HMOX1 protein]; Staurosporine inhibits the reaction [hydroquinone results in increased expression of HMOX1 mRNA]; Staurosporine inhibits the reaction [hydroquinone results in increased expression of HMOX1 protein]		 CTD PMID:12788823 PMID:18048804 PMID:23290930 PMID:24740755 PMID:28108387 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor multiple interactions
affects response to substance		 ISO
EXP		 HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]; TRP53 protein affects the reaction [HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]]
HR protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; HR protein inhibits the reaction [Staurosporine results in increased expression of TP53 protein]
HR protein affects the susceptibility to Staurosporine		 CTD PMID:20886113 NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
affects activity		 EXP IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]
Staurosporine affects the activity of IGF1 protein		 CTD PMID:11548882 PMID:19406941 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il33 interleukin 33 multiple interactions
increases expression		 ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Staurosporine results in increased expression of IL33 protein] CTD PMID:25747661 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP Staurosporine inhibits the reaction [IL4 protein promotes the reaction [Ionomycin results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [IL4 protein results in increased expression of TNFRSF4 protein]] CTD PMID:9766631 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 decreases activity ISO Staurosporine results in decreased activity of IL5 protein CTD PMID:12562334 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO
EXP		 Staurosporine inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA]
Staurosporine inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]; Staurosporine promotes the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]		 CTD PMID:7648427 PMID:11306697 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 multiple interactions EXP Staurosporine inhibits the reaction [INS protein results in increased uptake of cobaltous chloride] CTD PMID:14622148 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO Staurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL mRNA]; Staurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL protein]; Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]; Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL protein] CTD PMID:10198263 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Staurosporine inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGAM protein] CTD PMID:18500357 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein] CTD PMID:16393473 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation		 EXP Staurosporine inhibits the reaction [Acetaldehyde results in increased expression of JUN mRNA]
Staurosporine results in increased phosphorylation of JUN protein		 CTD PMID:7945571 PMID:9751194 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kng1 kininogen 1 decreases activity EXP Staurosporine results in decreased activity of KNG1 CTD PMID:1334751 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Lmna lamin A/C increases cleavage ISO Staurosporine results in increased cleavage of LMNA protein CTD PMID:26124276 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP		 Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Staurosporine promotes the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]
Staurosporine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]
Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11035063 PMID:15177934 PMID:15542774 PMID:16251475 PMID:17003101 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Staurosporine promotes the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]
Staurosporine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]
Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11035063 PMID:15177934 PMID:15542774 PMID:16251475 PMID:17003101 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO
EXP		 Staurosporine inhibits the reaction [oxophenylarsine results in increased phosphorylation of MAPT protein] CTD PMID:10737602 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mark1 microtubule affinity regulating kinase 1 multiple interactions ISO Staurosporine inhibits the reaction [oxophenylarsine results in increased activity of MARK1 protein] CTD PMID:10737602 NCBI chr13:96,450,189...96,555,304
Ensembl chr13:96,451,487...96,555,173 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases cleavage
decreases response to substance		 ISO Staurosporine results in increased cleavage of MCL1 protein
MCL1 results in decreased susceptibility to Staurosporine		 CTD PMID:15217956 PMID:16007152 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]] CTD PMID:15542774 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Staurosporine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein] CTD PMID:16251475 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases response to substance		 ISO MYC protein inhibits the reaction [Staurosporine results in increased abundance of Reactive Oxygen Species]; Staurosporine promotes the reaction [MYC protein binds to GCLC promoter]; Staurosporine promotes the reaction [MYC protein binds to GCLM promoter]
MYC protein results in decreased susceptibility to Staurosporine		 CTD PMID:17628013 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nefl neurofilament light chain multiple interactions EXP Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21879721 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nefm neurofilament medium chain multiple interactions EXP Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21879721 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression		 ISO Staurosporine inhibits the reaction [Ethanol affects the localization of NFE2L2 protein]; Staurosporine inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]
Staurosporine results in decreased expression of NFE2L2 protein modified form		 CTD PMID:22530035 PMID:30703377 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Staurosporine inhibits the reaction [bisphenol A results in increased expression of NFKB1 protein] CTD PMID:20499049 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO
EXP		 Staurosporine inhibits the reaction [NGF results in increased susceptibility to Capsaicin]
Staurosporine inhibits the reaction [NGF protein results in increased uptake of Calcium]		 CTD PMID:1374475 PMID:12815188 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Staurosporine inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein] CTD PMID:14534150 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Staurosporine inhibits the reaction [MBF1 protein results in increased secretion of NPPA protein] CTD PMID:12729799 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP
ISO		 Staurosporine inhibits the reaction [benz(a)anthracene results in increased activity of NQO1 protein]
Staurosporine inhibits the reaction [Smoke analog results in increased expression of NQO1 protein]		 CTD PMID:7587946 PMID:28108387 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP Staurosporine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [imetit results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [methylhistaprodifen results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [Neurotransmitter Agents results in increased expression of NTF3 protein] CTD PMID:19854260 PMID:21276809 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Nts neurotensin multiple interactions
increases activity		 ISO Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]; Staurosporine promotes the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; Tetradecanoylphorbol Acetate inhibits the reaction [Staurosporine results in increased activity of NTS protein] CTD PMID:15177934 PMID:18313772 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
increases expression		 ISO
EXP		 SOD2 mutant form inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; Staurosporine affects the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
EOMES protein inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in increased cleavage of PARP1 protein]]; Staurosporine promotes the reaction [Acetaldehyde results in increased cleavage of PARP1 protein]
Staurosporine results in increased expression of PARP1 protein modified form		 CTD PMID:10704466 PMID:11035063 PMID:18451153 PMID:21447800 PMID:22639866 More... NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Staurosporine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Hydrogen Peroxide co-treated with Staurosporine] results in increased acetylation of PPARGC1A protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in increased acetylation of PPARGC1A protein] CTD PMID:23293585 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta affects localization EXP Staurosporine affects the localization of PPP2R2B protein CTD PMID:18940801 NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha decreases response to substance
increases cleavage		 ISO PPP3CA protein results in decreased susceptibility to Staurosporine
Staurosporine results in increased cleavage of PPP3CA protein		 CTD PMID:10679475 PMID:10898953 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO Staurosporine inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein] CTD PMID:11796722 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO
EXP		 Staurosporine affects the localization of and affects the activity of PRKCA protein
[linsidomine co-treated with Staurosporine] results in decreased expression of PRKCA protein; Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; Staurosporine inhibits the reaction [linsidomine results in increased phosphorylation of PRKCA protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]		 CTD PMID:11994256 PMID:14678745 PMID:16225760 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO
EXP		 Staurosporine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]
Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]		 CTD PMID:14678745 PMID:17171638 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prl prolactin multiple interactions ISO Staurosporine inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA] CTD PMID:7648427 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Psen2 presenilin 2 multiple interactions ISO pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]; PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]; Staurosporine promotes the reaction [PSEN2 protein mutant form results in increased expression of APP protein] CTD PMID:12556443 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions
decreases phosphorylation		 EXP Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PTGER3 protein alternative form]
Staurosporine results in decreased phosphorylation of PTGER3 protein alternative form		 CTD PMID:15937517 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Ptges3 prostaglandin E synthase 3 increases cleavage ISO Staurosporine results in increased cleavage of PTGES3 protein CTD PMID:26124276 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Staurosporine inhibits the reaction [Nicotine results in increased expression of PTGS2] CTD PMID:17003101 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Staurosporine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; Staurosporine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
Staurosporine inhibits the reaction [bisphenol A results in increased expression of RELA protein]		 CTD PMID:20499049 PMID:24021941 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ret ret proto-oncogene decreases expression EXP Staurosporine results in decreased expression of RET protein CTD PMID:17555550 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B multiple interactions ISO [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SDHB protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SDHB protein] CTD PMID:23293585 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293 		JBrowse link
G Set Set nuclear proto-oncogene multiple interactions ISO Staurosporine affects the reaction [Formaldehyde affects the localization of SET protein alternative form] CTD PMID:36534342 NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein] CTD PMID:23293585 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions
decreases phosphorylation		 ISO [Staurosporine results in decreased phosphorylation of SLC11A2 protein] which results in decreased uptake of Iron CTD PMID:27681840 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc12a5 solute carrier family 12 member 5 increases activity
multiple interactions		 ISO Staurosporine results in increased activity of SLC12A5 protein
Staurosporine inhibits the reaction [SLC12A5 protein results in increased import of Thallium]		 CTD PMID:20086212 NCBI chr 3:153,696,517...153,735,801
Ensembl chr 3:153,696,517...153,735,765 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions
decreases activity		 EXP Staurosporine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; Staurosporine inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]
Staurosporine results in decreased activity of SLC1A1 protein		 CTD PMID:17382927 PMID:22511482 PMID:23262392 PMID:23602688 PMID:24355585 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP Staurosporine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein] CTD PMID:26988466 NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate affects the localization of SLC22A9 protein]; Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate results in decreased activity of SLC22A9 protein] CTD PMID:17341544 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions ISO Staurosporine inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA] CTD PMID:15142038 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910 		JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO Staurosporine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases activity		 ISO SNCA protein affects the reaction [Staurosporine results in increased activity of SLC6A3 protein] CTD PMID:19032594 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 increases activity ISO staurosporine increases activity of SLC6A4 protein in placental choriocarcinoma cells RGD PMID:7615516 RGD:38500207 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Snca synuclein alpha multiple interactions ISO [Staurosporine co-treated with Rotenone] promotes the reaction [SNCA protein binds to SNCA protein]; SNCA protein affects the reaction [Staurosporine results in increased activity of SLC6A3 protein] CTD PMID:19032594 PMID:19114014 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SOD2 protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SOD2 protein]; SOD2 mutant form inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; SOD2 mutant form inhibits the reaction [Staurosporine results in increased expression of HMOX1 protein] CTD PMID:23293585 PMID:24740755 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 multiple interactions
increases cleavage		 ISO Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]; VASP mutant form promotes the reaction [Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]]
Staurosporine results in increased cleavage of SPTAN1 protein		 CTD PMID:18182247 PMID:21683092 PMID:26124276 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] CTD PMID:18448488 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of SYNCRIP protein] CTD PMID:19331829 NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515 		JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO Staurosporine results in decreased activity of TERT protein CTD PMID:9434777 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Staurosporine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Staurosporine binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Staurosporine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein] CTD PMID:16716901 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]; Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL protein] CTD PMID:10198263 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 multiple interactions
increases expression		 EXP Staurosporine inhibits the reaction [IL4 protein promotes the reaction [Ionomycin results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Ionomycin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [IL4 protein results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF4 protein]; Staurosporine promotes the reaction [Mercuric Chloride results in increased expression of TNFRSF4 protein]
Staurosporine results in increased expression of TNFRSF4 protein		 CTD PMID:9766631 NCBI chr 5:166,606,909...166,609,599
Ensembl chr 5:166,606,909...166,609,599 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO
EXP		 Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]; Staurosporine promotes the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]
TRP53 protein affects the reaction [HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]]
HR protein inhibits the reaction [Staurosporine results in increased expression of TP53 protein]		 CTD PMID:15542774 PMID:20886113 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions ISO VASP mutant form promotes the reaction [Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]] CTD PMID:18182247 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions EXP 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Staurosporine promotes the reaction [VDAC1 protein binds to VDAC1 protein]]; Staurosporine promotes the reaction [VDAC1 protein binds to VDAC1 protein] CTD PMID:20937774 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Vdr vitamin D receptor increases cleavage ISO Staurosporine results in increased cleavage of VDR protein CTD PMID:18832097 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Staurosporine inhibits the reaction [VEGFA protein results in increased abundance of phosphatidylbutanol]; Staurosporine inhibits the reaction [VEGFA protein results in increased expression of HMOX1 protein] CTD PMID:12788823 PMID:14704231 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin multiple interactions EXP Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21879721 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Wt1 WT1 transcription factor increases expression ISO Staurosporine results in increased expression of WT1 protein CTD PMID:12914969 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        biochemical role 19496
          metabolite 19484
            alkaloid 7817
              indole alkaloid 1944
                indolocarbazole alkaloid 158
                  3'-demethylstaurosporine 0
                  7-oxo-3,8,9-trihydroxy staurosporine 0
                  7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine 0
                  erdasporine A 0
                  erdasporine B + 0
                  erdasporine C 0
                  staurosporine + 159
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                organic heterocyclic compound 18862
                                  organic heteropolycyclic compound 18301
                                    indolocarbazole 242
                                      indolocarbazole alkaloid 158
                                        3'-demethylstaurosporine 0
                                        7-oxo-3,8,9-trihydroxy staurosporine 0
                                        7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine 0
                                        erdasporine A 0
                                        erdasporine B + 0
                                        erdasporine C 0
                                        staurosporine + 159
paths to the root