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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:clozapine
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Accession:CHEBI:3766 term browser browse the term
Definition:A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Synonyms:exact_synonym: 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
 related_synonym: Clozapin;   Formula=C18H19ClN4;   InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3;   InChIKey=QZUDBNBUXVUHMW-UHFFFAOYSA-N;   SMILES=N1=C(C2=CC=CC=C2NC3=CC=C(C=C13)Cl)N4CCN(CC4)C;   clozapina;   clozapinum
 xref: Beilstein:0764984;   CAS:5786-21-0;   DrugBank:DB00363;   Drug_Central:722;   HMDB:HMDB0014507;   KEGG:C06924;   KEGG:D00283
 xref_mesh: MESH:D003024
 xref: PMID:18690109;   PMID:18766167;   PMID:20825390;   PMID:24219174;   Patent:FR1334944;   Patent:NL293201;   Patent:US3539573;   Reaxys:764984;   Wikipedia:Clozapine



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clozapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 increases expression ISO Clozapine results in increased expression of AARS protein CTD PMID:34122009 NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Clozapine results in decreased activity of ABCB11 protein CTD PMID:22646477 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
EXP
ISO
Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]
Clozapine results in decreased activity of ABCB1 protein
CTD PMID:9111066 PMID:16810505 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions EXP Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter] CTD PMID:9111066 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abce1 ATP binding cassette subfamily E member 1 increases expression ISO Clozapine results in increased expression of ABCE1 protein CTD PMID:34122009 NCBI chr19:28,205,566...28,230,489
Ensembl chr19:28,205,555...28,230,489
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Clozapine results in increased expression of ABCG1 mRNA CTD PMID:17346280 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Ablim2 actin binding LIM protein family, member 2 increases expression ISO Clozapine results in increased expression of ABLIM2 mRNA CTD PMID:17346280 NCBI chr14:74,865,409...74,990,334
Ensembl chr14:74,866,281...74,990,334
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression ISO Clozapine results in increased expression of ACAT2 mRNA CTD PMID:17052361 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression ISO Clozapine results in increased expression of ACOT2 protein CTD PMID:34122009 NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Acot7 acyl-CoA thioesterase 7 decreases expression ISO Clozapine results in decreased expression of ACOT7 protein CTD PMID:34122009 NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA CTD PMID:23226405 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Actb actin, beta decreases expression ISO Clozapine results in decreased expression of ACTB protein CTD PMID:34122009 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Actbl2 actin, beta-like 2 increases expression ISO Clozapine results in increased expression of ACTBL2 protein CTD PMID:34122009 NCBI chr 2:42,858,020...42,860,767
Ensembl chr 2:42,858,020...42,860,767
JBrowse link
G Actr3 actin related protein 3 decreases expression ISO Clozapine results in decreased expression of ACTR3 protein CTD PMID:34122009 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124
JBrowse link
G Actr5 actin related protein 5 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of ACTR5 protein CTD PMID:34122009 NCBI chr 3:147,282,461...147,296,110
Ensembl chr 3:147,282,624...147,296,110
JBrowse link
G Adam1a ADAM metallopeptidase domain 1a decreases expression EXP Clozapine results in decreased expression of ADAM1A mRNA CTD PMID:16715494 NCBI chr12:35,017,433...35,020,300
Ensembl chr12:35,017,315...35,020,311
JBrowse link
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of ADAMTS12 protein CTD PMID:34122009 NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629
JBrowse link
G Adcy5 adenylate cyclase 5 affects response to substance
multiple interactions
ISO ADCY5 protein affects the susceptibility to Clozapine
SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]
CTD PMID:12223546 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
increases expression
multiple interactions
ISO
EXP
Clozapine results in decreased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]
CTD PMID:17933447 PMID:18162013 PMID:20564506 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Clozapine results in decreased expression of ADORA2A mRNA CTD PMID:17266109 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions EXP Clozapine binds to and results in decreased activity of ADRA1A protein CTD PMID:16545797 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 decreases expression ISO Clozapine results in decreased expression of AGPAT1 mRNA CTD PMID:14647396 NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278
JBrowse link
G Agt angiotensinogen multiple interactions ISO Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]] CTD PMID:11549694 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 increases expression ISO Clozapine results in increased expression of AIMP1 protein CTD PMID:34122009 NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728
JBrowse link
G Ak1 adenylate kinase 1 decreases expression ISO Clozapine results in decreased expression of AK1 protein CTD PMID:34122009 NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
JBrowse link
G Akap2 A-kinase anchoring protein 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of AKAP2 protein CTD PMID:34122009 NCBI chr 5:72,536,986...72,648,524
Ensembl chr 5:72,181,718...72,648,524
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
decreases expression
increases phosphorylation
ISO
EXP
Clozapine results in increased expression of AKT1 mRNA; Clozapine results in increased expression of AKT1 protein
Clozapine results in decreased expression of AKT1 mRNA
Clozapine results in increased phosphorylation of AKT1 protein
CTD PMID:15860345 PMID:19440698 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 increases expression EXP Clozapine results in increased expression of AKT2 mRNA CTD PMID:15860345 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Alb albumin multiple interactions
affects binding
EXP
ISO
Clozapine results in decreased expression of and results in decreased reduction of ALB protein
Clozapine binds to ALB protein
[[[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine] which affects the activity of ALB protein; [[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine; [stearic acid binds to ALB protein] which affects the susceptibility to Clozapine; stearic acid inhibits the reaction [Clozapine binds to ALB protein]
CTD PMID:31400341 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Clozapine results in increased expression of ALDH1A1 mRNA CTD PMID:17266109 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Clozapine results in increased expression of ALDOA mRNA CTD PMID:15860345 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Aldob aldolase, fructose-bisphosphate B increases expression ISO Clozapine results in increased expression of ALDOB protein CTD PMID:34122009 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of ALDOC mRNA
Clozapine results in increased expression of ALDOC mRNA
CTD PMID:15860345 PMID:16465460 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
JBrowse link
G Alpp alkaline phosphatase, placental multiple interactions ISO Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA] CTD PMID:16036225 NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606
JBrowse link
G Alyref Aly/REF export factor decreases expression ISO Clozapine results in decreased expression of ALYREF protein CTD PMID:34122009 NCBI chr10:105,871,306...105,875,076
Ensembl chr10:105,871,306...105,875,069
JBrowse link
G Anxa1 annexin A1 decreases expression ISO Clozapine results in decreased expression of ANXA1 protein CTD PMID:34122009 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Anxa5 annexin A5 decreases expression ISO Clozapine results in decreased expression of ANXA5 protein CTD PMID:34122009 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Anxa6 annexin A6 decreases expression ISO Clozapine results in decreased expression of ANXA6 protein CTD PMID:34122009 NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Clozapine results in decreased expression of AP1S1 mRNA CTD PMID:17175557 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 increases expression EXP Clozapine results in increased expression of AP2B1 mRNA CTD PMID:15860345 NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013
JBrowse link
G Ap3b1 adaptor related protein complex 3 subunit beta 1 increases expression ISO Clozapine results in increased expression of AP3B1 protein CTD PMID:34122009 NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935
JBrowse link
G Apoa5 apolipoprotein A5 affects response to substance EXP APOA5 gene polymorphism affects the susceptibility to Clozapine CTD PMID:17726453 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
JBrowse link
G Apod apolipoprotein D increases expression ISO Clozapine results in increased expression of APOD mRNA; Clozapine results in increased expression of APOD protein CTD PMID:11158250 PMID:14647396 PMID:17266109 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression EXP Clozapine results in decreased expression of ARC mRNA CTD PMID:18208916 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Arhgef9 Cdc42 guanine nucleotide exchange factor 9 decreases expression ISO Clozapine results in decreased expression of ARHGEF9 mRNA CTD PMID:17266109 NCBI chr  X:59,919,560...60,077,538
Ensembl chr  X:59,920,870...60,077,513
JBrowse link
G Arl8a ADP-ribosylation factor like GTPase 8A decreases expression ISO Clozapine results in decreased expression of ARL8A protein CTD PMID:34122009 NCBI chr13:46,585,845...46,594,851
Ensembl chr13:46,585,845...46,594,851
JBrowse link
G Armt1 acidic residue methyltransferase 1 increases expression ISO Clozapine results in increased expression of ARMT1 protein CTD PMID:34122009 NCBI chr 1:40,894,558...40,918,302
Ensembl chr 1:40,894,550...40,918,302
JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 affects expression ISO Clozapine affects the expression of ARPC4 mRNA CTD PMID:14647396 NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Clozapine results in increased expression of ASAH1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Clozapine results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Asph aspartate-beta-hydroxylase increases expression ISO Clozapine results in increased expression of ASPH protein CTD PMID:34122009 NCBI chr 5:22,603,879...22,814,107
Ensembl chr 5:22,603,486...22,813,876
JBrowse link
G Ass1 argininosuccinate synthase 1 increases expression ISO Clozapine results in increased expression of ASS1 protein CTD PMID:34122009 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Atad3a ATPase family, AAA domain containing 3A decreases expression ISO Clozapine results in decreased expression of ATAD3A protein CTD PMID:34122009 NCBI chr 5:166,350,302...166,370,492
Ensembl chr 5:166,350,304...166,370,482
JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 increases expression ISO Clozapine results in increased expression of ATP2A3 protein CTD PMID:34122009 NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression EXP Clozapine results in decreased expression of ATP5F1B protein CTD PMID:19441803 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b increases expression ISO Clozapine results in increased expression of ATP5F1 protein CTD PMID:34122009 NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418
JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A decreases expression ISO Clozapine results in decreased expression of ATP6V1A protein CTD PMID:34122009 NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694
JBrowse link
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 decreases expression ISO Clozapine results in decreased expression of ATP6V1B1 protein CTD PMID:34122009 NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475
JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 decreases expression EXP
ISO
Clozapine results in decreased expression of ATP6V1B2 protein CTD PMID:19441803 PMID:34122009 NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745
JBrowse link
G Atxn10 ataxin 10 increases expression ISO Clozapine results in increased expression of ATXN10 protein CTD PMID:34122009 NCBI chr 7:116,441,768...116,565,093
Ensembl chr 7:116,441,613...116,565,087
JBrowse link
G Axin2 axin 2 decreases expression EXP Clozapine results in decreased expression of AXIN2 mRNA CTD PMID:16715494 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
decreases expression
ISO
EXP
Clozapine results in increased expression of BAX mRNA; Clozapine results in increased expression of BAX protein
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]
Clozapine results in decreased expression of BAX protein
CTD PMID:16160616 PMID:17069804 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Baz1b bromodomain adjacent to zinc finger domain, 1B multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of BAZ1B protein CTD PMID:34122009 NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases expression ISO Clozapine results in decreased expression of BCAR1 protein CTD PMID:34122009 NCBI chr19:39,679,218...39,713,952
Ensembl chr19:39,679,204...39,713,907
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Clozapine results in increased expression of BCL2 mRNA; Clozapine results in increased expression of BCL2 protein CTD PMID:15126120 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l14 Bcl2-like 14 decreases expression ISO Clozapine results in decreased expression of BCL2L14 protein CTD PMID:34122009 NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
increases expression
EXP Clozapine results in decreased expression of BDNF mRNA
Clozapine results in increased expression of BDNF mRNA; Clozapine results in increased expression of BDNF protein
CTD PMID:11488957 PMID:12478621 PMID:17442489 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bet1l Bet1 golgi vesicular membrane trafficking protein-like decreases expression EXP Clozapine results in decreased expression of BET1L mRNA CTD PMID:15860345 NCBI chr 1:195,930,165...195,935,072
Ensembl chr 1:195,931,411...195,935,040
JBrowse link
G Bik BCL2-interacting killer multiple interactions
increases expression
ISO CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA] CTD PMID:16160616 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
JBrowse link
G Bptf bromodomain PHD finger transcription factor decreases expression ISO Clozapine results in decreased expression of BPTF mRNA CTD PMID:14647396 NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769
JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 increases expression ISO Clozapine results in increased expression of BZW1 protein CTD PMID:34122009 NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A decreases expression ISO
EXP
Clozapine results in decreased expression of CACNA1A mRNA CTD PMID:14647396 PMID:16715494 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
JBrowse link
G Calm2 calmodulin 2 increases expression EXP Clozapine results in increased expression of CALM2 mRNA CTD PMID:19289156 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
JBrowse link
G Calr calreticulin decreases expression ISO Clozapine results in decreased expression of CALR protein CTD PMID:34122009 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Calu calumenin decreases expression ISO Clozapine results in decreased expression of CALU protein CTD PMID:34122009 NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of CAMK2A mRNA
Clozapine results in increased expression of CAMK2A mRNA
Clozapine results in decreased expression of CAMK2A protein
CTD PMID:15860345 PMID:17266109 PMID:19289156 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression EXP Clozapine results in decreased expression of CAMK2B mRNA CTD PMID:15860345 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta decreases expression EXP Clozapine results in decreased expression of CAMK2D mRNA CTD PMID:15860345 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV increases expression
decreases expression
EXP Clozapine results in increased expression of CAMK4 mRNA
Clozapine results in decreased expression of CAMK4 protein
CTD PMID:15860345 PMID:19289156 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 decreases expression EXP Clozapine results in decreased expression of CAMKK1 protein CTD PMID:19289156 NCBI chr10:57,637,335...57,660,498
Ensembl chr10:57,637,391...57,660,498
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 decreases expression EXP Clozapine results in decreased expression of CAMKK2 protein CTD PMID:19289156 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
JBrowse link
G Canx calnexin decreases expression ISO Clozapine results in decreased expression of CANX protein CTD PMID:34122009 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
JBrowse link
G Cars cysteinyl-tRNA synthetase increases expression ISO Clozapine results in increased expression of CARS protein CTD PMID:34122009 NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
JBrowse link
G Cartpt CART prepropeptide decreases expression EXP Clozapine results in decreased expression of CARTPT mRNA CTD PMID:14696011 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
JBrowse link
G Casp1 caspase 1 increases activity ISO Clozapine results in increased activity of CASP1 protein CTD PMID:34935985 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
Clozapine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein]
CTD PMID:22700542 PMID:24709159 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Clozapine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Cat catalase multiple interactions ISO Clozapine inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Clozapine inhibits the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]] CTD PMID:14730115 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 increases expression ISO Clozapine results in increased expression of CCAR1 protein CTD PMID:34122009 NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
JBrowse link
G Ccdc47 coiled-coil domain containing 47 increases expression
multiple interactions
ISO Clozapine results in increased expression of CCDC47 protein
[Cuprizone co-treated with Clozapine] results in increased expression of CCDC47 protein
CTD PMID:34122009 NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881
JBrowse link
G Cck cholecystokinin multiple interactions
increases expression
EXP Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]
Clozapine results in increased expression of CCK mRNA
CTD PMID:10974607 PMID:16567023 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Cckbr cholecystokinin B receptor increases expression ISO Clozapine results in increased expression of CCKBR mRNA CTD PMID:17266109 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 decreases expression ISO Clozapine results in decreased expression of CCL1 mRNA CTD PMID:17346280 NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Clozapine results in decreased expression of CCND1 mRNA CTD PMID:15860345 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 increases expression EXP Clozapine results in increased expression of CCND3 mRNA CTD PMID:15860345 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccnl1 cyclin L1 increases expression EXP Clozapine results in increased expression of CCNL1 mRNA CTD PMID:15860345 NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 decreases expression ISO Clozapine results in decreased expression of CCT7 protein CTD PMID:34122009 NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580
JBrowse link
G Cd276 Cd276 molecule decreases expression ISO Clozapine results in decreased expression of CD276 protein CTD PMID:34122009 NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380
JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase increases expression ISO Clozapine results in increased expression of CDIPT protein CTD PMID:34122009 NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Clozapine results in increased expression of CDK4 mRNA CTD PMID:15860345 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk5 cyclin-dependent kinase 5 increases expression EXP Clozapine results in increased expression of CDK5 mRNA CTD PMID:15860345 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression ISO Clozapine results in increased expression of CDK5R1 mRNA CTD PMID:17266109 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression
ISO Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]
Clozapine results in increased expression of CEBPA mRNA; Clozapine results in increased expression of CEBPA protein
CTD PMID:20564506 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cenpv centromere protein V increases expression ISO Clozapine results in increased expression of CENPV protein CTD PMID:34122009 NCBI chr10:47,214,479...47,228,552
Ensembl chr10:47,214,490...47,228,761
JBrowse link
G Cfap210 cilia and flagella associated protein 210 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of CCDC173 protein CTD PMID:34122009 NCBI chr 3:54,520,455...54,554,677
Ensembl chr 3:54,520,458...54,554,607
JBrowse link
G Chchd2l3 coiled-coil-helix-coiled-coil-helix domain containing protein 2-like 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of CHCHD2 protein CTD PMID:34122009 NCBI chr 9:94,500,439...94,501,110
NCBI chr 9:94,500,629...94,501,122
Ensembl chr 9:94,500,432...94,501,128
JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 decreases expression ISO Clozapine results in decreased expression of CHD4 protein CTD PMID:34122009 NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541
JBrowse link
G Chga chromogranin A decreases expression
increases expression
EXP Clozapine results in decreased expression of CHGA mRNA
Clozapine results in increased expression of CHGA mRNA
CTD PMID:12437575 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
JBrowse link
G Chl1 cell adhesion molecule L1-like decreases expression ISO Clozapine results in decreased expression of CHL1 mRNA CTD PMID:14647396 NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265
JBrowse link
G Chn1 chimerin 1 decreases expression ISO Clozapine results in decreased expression of CHN1 mRNA CTD PMID:14647396 NCBI chr 3:58,509,822...58,676,774
Ensembl chr 3:58,510,536...58,676,490
JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression ISO Clozapine results in increased expression of CHORDC1 protein CTD PMID:34122009 NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects binding
increases expression
multiple interactions
ISO
EXP
Clozapine analog binds to CHRM1 protein; Clozapine binds to CHRM1 protein
Clozapine results in increased expression of CHRM1 protein
Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein]
CTD PMID:11997696 PMID:16983399 PMID:18806925 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Ckap4 cytoskeleton-associated protein 4 increases expression ISO Clozapine results in increased expression of CKAP4 protein CTD PMID:34122009 NCBI chr 7:19,230,814...19,238,914
Ensembl chr 7:19,230,203...19,238,914
JBrowse link
G Clic1 chloride intracellular channel 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of CLIC1 protein CTD PMID:34122009 NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712
JBrowse link
G Clic4 chloride intracellular channel 4 increases expression ISO Clozapine results in increased expression of CLIC4 protein CTD PMID:34122009 NCBI chr 5:147,456,819...147,513,278
Ensembl chr 5:147,453,712...147,513,452
JBrowse link
G Clock clock circadian regulator affects response to substance ISO CLOCK gene SNP affects the susceptibility to Clozapine CTD PMID:15331141 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400
JBrowse link
G Clta clathrin, light chain A decreases expression EXP Clozapine results in decreased expression of CLTA mRNA CTD PMID:15860345 NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472
JBrowse link
G Cltb clathrin, light chain B decreases expression EXP Clozapine results in decreased expression of CLTB mRNA CTD PMID:15860345 NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression
increases expression
ISO Clozapine results in decreased expression of CNP mRNA
Clozapine results in decreased expression of CNP protein
Clozapine results in increased expression of CNP mRNA
CTD PMID:17266109 PMID:34122009 NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
JBrowse link
G Coil coilin increases expression EXP Clozapine results in increased expression of COIL mRNA CTD PMID:16715494 NCBI chr10:73,789,077...73,810,378
Ensembl chr10:73,789,488...73,810,393
JBrowse link
G Col5a2 collagen type V alpha 2 chain multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of COL5A2 protein CTD PMID:34122009 NCBI chr 9:47,448,736...47,598,396
Ensembl chr 9:47,448,736...47,598,154
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions
affects response to substance
increases response to substance
EXP
ISO
[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]
COMT protein affects the susceptibility to Clozapine
COMT gene polymorphism results in increased susceptibility to Clozapine
CTD PMID:15190105 PMID:17123785 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cops3 COP9 signalosome subunit 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of COPS3 protein CTD PMID:34122009 NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597
JBrowse link
G Coro1b coronin 1B decreases expression ISO Clozapine results in decreased expression of CORO1B protein CTD PMID:34122009 NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416
JBrowse link
G Cplx2 complexin 2 decreases expression ISO Clozapine results in decreased expression of CPLX2 mRNA CTD PMID:17266109 NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855
JBrowse link
G Cpn1 carboxypeptidase N subunit 1 increases expression EXP Clozapine results in increased expression of CPN1 mRNA CTD PMID:16715494 NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465
JBrowse link
G Cpne1 copine 1 decreases expression ISO Clozapine results in decreased expression of CPNE1 protein CTD PMID:34122009 NCBI chr 3:144,587,548...144,629,603
Ensembl chr 3:144,588,995...144,598,636
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions EXP [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA CTD PMID:23226405 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation
ISO Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein]
Clozapine results in decreased phosphorylation of CREB1 protein
CTD PMID:12871586 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Clozapine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crhbp corticotropin releasing hormone binding protein decreases expression EXP Clozapine results in decreased expression of CRHBP mRNA CTD PMID:16715494 NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710
JBrowse link
G Crp C-reactive protein increases expression ISO Clozapine results in increased expression of CRP protein CTD PMID:17685758 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA] CTD PMID:16160616 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 decreases expression EXP Clozapine results in decreased expression of CSNK2A1 mRNA CTD PMID:16715494 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
JBrowse link
G Cst3 cystatin C increases expression ISO Clozapine results in increased expression of CST3 mRNA CTD PMID:14647396 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
JBrowse link
G Cstf1 cleavage stimulation factor subunit 1 decreases expression ISO Clozapine results in decreased expression of CSTF1 protein CTD PMID:34122009 NCBI chr 3:161,144,533...161,156,294
Ensembl chr 3:161,144,548...161,156,300
JBrowse link
G Cstf2 cleavage stimulation factor subunit 2 decreases expression ISO Clozapine results in decreased expression of CSTF2 protein CTD PMID:34122009 NCBI chr  X:97,253,559...97,279,476
Ensembl chr  X:97,253,586...97,279,476
JBrowse link
G Ctbp1 C-terminal binding protein 1 increases expression ISO Clozapine results in increased expression of CTBP1 protein CTD PMID:34122009 NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions
EXP Clozapine results in increased expression of CTNNB1 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]
CTD PMID:16144542 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctrl chymotrypsin-like increases expression EXP Clozapine results in increased expression of CTRL mRNA CTD PMID:16715494 NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626
JBrowse link
G Ctsk cathepsin K increases expression EXP Clozapine results in increased expression of CTSK mRNA CTD PMID:16715494 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Cttn cortactin increases expression ISO Clozapine results in increased expression of CTTN protein CTD PMID:34122009 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
JBrowse link
G Cul2 cullin 2 increases expression ISO Clozapine results in increased expression of CUL2 protein CTD PMID:34122009 NCBI chr17:54,169,086...54,210,197
Ensembl chr17:54,169,086...54,209,968
JBrowse link
G Cul3 cullin 3 increases expression ISO Clozapine results in increased expression of CUL3 protein CTD PMID:34122009 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions
increases secretion
ISO
EXP
Clozapine results in decreased expression of CXCL1 mRNA
belnacasan inhibits the reaction [Clozapine results in increased secretion of CXCL1 protein]
CTD PMID:17346280 PMID:34935985 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Clozapine results in decreased expression of CXCL1 mRNA CTD PMID:17346280 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyb5b cytochrome b5 type B increases expression EXP Clozapine results in increased expression of CYB5B mRNA CTD PMID:19441803 NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249
JBrowse link
G Cyb5r1 cytochrome b5 reductase 1 increases expression ISO Clozapine results in increased expression of CYB5R1 protein CTD PMID:34122009 NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases metabolic processing
EXP
ISO
Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Clozapine results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of Clozapine
CTD PMID:18493746 PMID:18809730 PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases response to substance
multiple interactions
increases metabolic processing
increases expression
affects metabolic processing
affects response to substance
decreases metabolic processing
ISO
EXP
CYP1A2 gene SNP results in decreased susceptibility to Clozapine
Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CYP1A2 protein results in increased metabolism of Clozapine
Clozapine results in increased expression of CYP1A2 mRNA
CYP1A2 gene polymorphism affects the metabolism of Clozapine; CYP1A2 protein affects the metabolism of Clozapine; CYP1A2 protein polymorphism affects the metabolism of Clozapine
[Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Smoke affects the reaction [CYP1A2 gene polymorphism affects the metabolism of Clozapine]; Smoke promotes the reaction [CYP1A2 protein results in increased metabolism of Clozapine]
CYP1A2 gene SNP affects the susceptibility to Clozapine; CYP1A2 protein affects the susceptibility to Clozapine
CYP1A2 gene SNP results in increased metabolism of Clozapine; CYP1A2 protein results in increased metabolism of Clozapine
CYP1A2 gene SNP results in decreased metabolism of Clozapine
CTD PMID:11151749 PMID:11763009 PMID:12919186 PMID:12969762 PMID:15206669 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
decreases activity
ISO CYP1B1 protein results in increased metabolism of Clozapine
Clozapine results in decreased activity of CYP1B1 protein
CTD PMID:18809730 PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
increases metabolic processing
ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CYP2C19 protein results in increased metabolism of Clozapine
CTD PMID:18809730 PMID:23397584 PMID:27320963 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of Clozapine CTD PMID:18809730 PMID:27320963
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
increases metabolic processing
multiple interactions
ISO CYP2D6 protein affects the metabolism of Clozapine
CYP2D6 protein results in increased metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CTD PMID:15286053 PMID:18809730 PMID:23397584 PMID:27320963 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases metabolic processing ISO CYP2J2 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
affects metabolic processing
multiple interactions
ISO CYP3A4 protein results in increased metabolism of Clozapine
CYP3A4 protein affects the metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]
CTD PMID:15286053 PMID:18809730 PMID:21402137 PMID:23397584 PMID:27320963 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Dab1 DAB adaptor protein 1 increases expression EXP Clozapine results in increased expression of DAB1 mRNA CTD PMID:19359144 NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552
JBrowse link
G Dcaf6 DDB1 and CUL4 associated factor 6 decreases expression ISO Clozapine results in decreased expression of DCAF6 mRNA CTD PMID:14647396 NCBI chr13:77,626,257...77,727,645
Ensembl chr13:77,626,307...77,727,512
JBrowse link
G Dclk1 doublecortin-like kinase 1 increases expression ISO
EXP
Clozapine results in increased expression of DCLK1 mRNA CTD PMID:15860345 PMID:18797397 NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956
JBrowse link
G Ddc dopa decarboxylase multiple interactions
increases expression
ISO Clozapine results in increased expression of and results in increased activity of DDC protein
Clozapine results in increased expression of DDC mRNA
CTD PMID:16415089 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Ddx46 DEAD-box helicase 46 increases expression ISO Clozapine results in increased expression of DDX46 protein CTD PMID:34122009 NCBI chr17:8,944,197...8,988,476
Ensembl chr17:8,944,454...8,988,439
JBrowse link
G Dennd10 DENN domain containing 10 increases expression EXP Clozapine results in increased expression of DENND10 mRNA CTD PMID:16715494 NCBI chr 1:259,950,928...259,974,456
Ensembl chr 1:259,950,866...259,974,455
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Clozapine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
JBrowse link
G Dgcr6 DiGeorge syndrome critical region gene 6 decreases expression ISO Clozapine results in decreased expression of DGCR6 protein CTD PMID:34122009 NCBI chr11:82,927,725...82,932,823
Ensembl chr11:82,927,725...82,932,823
JBrowse link
G Dgka diacylglycerol kinase, alpha decreases expression EXP Clozapine results in decreased expression of DGKA mRNA CTD PMID:15860345 NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO Clozapine results in increased expression of DHCR24 protein CTD PMID:34122009 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression ISO Clozapine results in increased expression of DHCR7 mRNA CTD PMID:17052361 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
JBrowse link
G Dhx30 DExH-box helicase 30 increases expression ISO Clozapine results in increased expression of DHX30 protein CTD PMID:34122009 NCBI chr 8:110,064,751...110,096,954
Ensembl chr 8:110,064,752...110,097,381
JBrowse link
G Dhx38 DEAH-box helicase 38 decreases expression ISO Clozapine results in decreased expression of DHX38 protein CTD PMID:34122009 NCBI chr19:37,512,891...37,530,140
Ensembl chr19:37,512,891...37,530,140
JBrowse link
G Disc1 DISC1 scaffold protein decreases response to substance
affects response to substance
ISO DISC1 gene mutant form results in decreased susceptibility to Clozapine
DISC1 protein affects the susceptibility to Clozapine
CTD PMID:20531374 NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase decreases expression
increases expression
EXP
ISO
Clozapine results in decreased expression of DLAT mRNA
Clozapine results in increased expression of DLAT protein
CTD PMID:15860345 PMID:34122009 NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 increases expression ISO Clozapine results in increased expression of DLG2 protein CTD PMID:34122009 NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase decreases expression ISO Clozapine results in decreased expression of DLST protein CTD PMID:34122009 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
JBrowse link
G Dnah11 dynein, axonemal, heavy chain 11 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of DNAH11 protein CTD PMID:34122009 NCBI chr 6:138,839,175...139,155,554
Ensembl chr 6:138,839,177...139,155,536
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of DNAJA3 protein CTD PMID:34122009 NCBI chr10:10,855,510...10,880,175
Ensembl chr10:10,854,732...10,880,161
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 increases expression ISO Clozapine results in increased expression of DNAJB11 protein CTD PMID:34122009 NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
JBrowse link
G Dpf1 double PHD fingers 1 affects expression ISO Clozapine affects the expression of DPF1 mRNA CTD PMID:14647396 NCBI chr 1:84,602,212...84,615,954
Ensembl chr 1:84,602,336...84,615,950
JBrowse link
G Dpp3 dipeptidylpeptidase 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of DPP3 protein CTD PMID:34122009 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 decreases expression ISO Clozapine results in decreased expression of DPYSL3 protein CTD PMID:34122009 NCBI chr18:35,374,429...35,480,462
Ensembl chr18:35,377,181...35,480,157
JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 decreases expression ISO Clozapine results in decreased expression of DPYSL4 protein CTD PMID:34122009 NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914
JBrowse link
G Dr1 down-regulator of transcription 1 decreases expression ISO Clozapine results in decreased expression of DR1 protein CTD PMID:34122009 NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638
JBrowse link
G Drd1 dopamine receptor D1 affects binding
decreases expression
affects response to substance
ISO
EXP
Clozapine binds to DRD1 protein
Clozapine results in decreased expression of DRD1 mRNA
Clozapine analog binds to DRD1 protein
DRD1 gene polymorphism affects the susceptibility to Clozapine; DRD1 protein affects the susceptibility to Clozapine
CTD PMID:1352677 PMID:9723970 PMID:11997696 PMID:17092969 PMID:17266109 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding
affects response to substance
decreases expression
increases response to substance
ISO
EXP
[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein
Clozapine binds to DRD2 protein
DRD2 protein affects the susceptibility to Clozapine
Clozapine results in decreased expression of DRD2 mRNA
Clozapine analog binds to DRD2 protein; Clozapine binds to DRD2 protein
[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Clozapine binds to DRD2 protein alternative form
DRD2 gene SNP results in increased susceptibility to Clozapine
DRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to Clozapine
CTD PMID:1352677 PMID:9723970 PMID:11997696 PMID:12476322 PMID:15286066 More... NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 affects response to substance
multiple interactions
decreases response to substance
ISO DRD3 protein affects the susceptibility to Clozapine
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
DRD3 gene polymorphism results in decreased susceptibility to Clozapine
CTD PMID:15579174 PMID:20029384 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Drd4 dopamine receptor D4 affects binding
multiple interactions
affects response to substance
ISO
EXP
Clozapine binds to DRD4 protein
Clozapine binds to Drd4 protein
Clozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein]
Clozapine analog binds to DRD4 protein
DRD4 gene polymorphism affects the susceptibility to Clozapine
CTD
RGD
PMID:11997696 PMID:16223700 PMID:31323226 PMID:8078498 RGD:7248459 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Drp2 dystrophin related protein 2 increases expression EXP Clozapine results in increased expression of DRP2 mRNA alternative form CTD PMID:16715494 NCBI chr  X:97,607,577...97,658,115
Ensembl chr  X:97,607,719...97,655,684
JBrowse link
G Dtnbp1 dystrobrevin binding protein 1 increases response to substance
affects response to substance
ISO DTNBP1 gene polymorphism results in increased susceptibility to Clozapine
DTNBP1 protein affects the susceptibility to Clozapine
CTD PMID:19369910 NCBI chr17:19,685,218...19,776,668
Ensembl chr17:19,685,215...19,776,661
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Clozapine results in decreased expression of DUSP1 mRNA CTD PMID:15860345 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression EXP Clozapine results in decreased expression of DUSP6 mRNA CTD PMID:15860345 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Dvl3 dishevelled segment polarity protein 3 increases expression
multiple interactions
EXP Clozapine results in increased expression of DVL3 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]
CTD PMID:16144542 NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462
JBrowse link
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 decreases expression ISO Clozapine results in decreased expression of DYNC1LI1 protein CTD PMID:34122009 NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934
JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 decreases expression ISO Clozapine results in decreased expression of DYNC1LI2 protein CTD PMID:34122009 NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670
JBrowse link
G Edc4 enhancer of mRNA decapping 4 increases expression ISO Clozapine results in increased expression of EDC4 protein CTD PMID:34122009 NCBI chr19:33,774,062...33,786,054
Ensembl chr19:33,774,055...33,787,758
JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 increases expression ISO Clozapine results in increased expression of EEF1A2 protein CTD PMID:34122009 NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071
JBrowse link
G Eef1d eukaryotic translation elongation factor 1 delta decreases expression ISO Clozapine results in decreased expression of EEF1D protein CTD PMID:34122009 NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799
JBrowse link
G Egr1 early growth response 1 decreases expression EXP Clozapine results in decreased expression of EGR1 mRNA; Clozapine results in decreased expression of EGR1 protein CTD PMID:17028028 PMID:18208916 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr2 early growth response 2 affects expression
decreases expression
ISO
EXP
Clozapine affects the expression of EGR2 mRNA
Clozapine results in decreased expression of EGR2 protein
CTD PMID:17028028 PMID:19401217 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
JBrowse link
G Egr3 early growth response 3 affects response to substance ISO EGR3 protein affects the susceptibility to Clozapine CTD PMID:17637609 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
JBrowse link
G Eif2s3 eukaryotic translation initiation factor 2 subunit gamma increases expression ISO Clozapine results in increased expression of EIF2S3 protein CTD PMID:34122009 NCBI chr  X:58,916,513...58,939,923
Ensembl chr  X:58,917,490...58,940,686
JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of EIF3C protein CTD PMID:34122009 NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
JBrowse link
G Eif3j eukaryotic translation initiation factor 3, subunit J increases expression ISO Clozapine results in increased expression of EIF3J protein CTD PMID:34122009 NCBI chr 3:108,985,103...109,007,341
Ensembl chr 3:108,985,118...109,007,953
JBrowse link
G Eif3m eukaryotic translation initiation factor 3, subunit M multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of EIF3M protein CTD PMID:34122009 NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392
JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of EIF4A3 protein CTD PMID:34122009 NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of EIF4E protein CTD PMID:34122009 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif5b eukaryotic translation initiation factor 5B increases expression ISO Clozapine results in increased expression of EIF5B protein CTD PMID:34122009 NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482
JBrowse link
G Eif6 eukaryotic translation initiation factor 6 decreases expression ISO Clozapine results in decreased expression of EIF6 protein CTD PMID:34122009 NCBI chr 3:144,325,038...144,331,396
Ensembl chr 3:144,325,036...144,331,401
JBrowse link
G Elk1 ETS transcription factor ELK1 decreases phosphorylation ISO Clozapine results in decreased phosphorylation of ELK1 protein CTD PMID:12871586 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Eno1 enolase 1 increases expression EXP Clozapine results in increased expression of ENO1 mRNA CTD PMID:15860345 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Eno3 enolase 3 increases expression ISO Clozapine results in increased expression of ENO3 protein CTD PMID:34122009 NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
JBrowse link
G Epha7 Eph receptor A7 increases expression ISO Clozapine results in increased expression of EPHA7 mRNA CTD PMID:17266109 NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112
JBrowse link
G Ephb3 Eph receptor B3 increases expression ISO Clozapine results in increased expression of EPHB3 protein CTD PMID:34122009 NCBI chr11:79,840,668...79,859,467
Ensembl chr11:79,840,668...79,859,370
JBrowse link
G Erap1 endoplasmic reticulum aminopeptidase 1 decreases expression ISO Clozapine results in decreased expression of ERAP1 protein CTD PMID:34122009 NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects phosphorylation EXP Clozapine affects the phosphorylation of ERBB2 protein CTD PMID:26961615 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions EXP Clozapine results in increased expression of and results in increased phosphorylation of ERBB4 protein CTD PMID:26961615 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
JBrowse link
G Erh ERH, mRNA splicing and mitosis factor increases expression ISO Clozapine results in increased expression of ERH protein CTD PMID:34122009 NCBI chr 6:100,280,930...100,291,449
Ensembl chr 6:100,280,930...100,291,210
JBrowse link
G Erp44 endoplasmic reticulum protein 44 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of ERP44 protein CTD PMID:34122009 NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761
JBrowse link
G Ewsr1 EWS RNA-binding protein 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of EWSR1 protein CTD PMID:34122009 NCBI chr14:79,965,365...79,994,108
Ensembl chr14:79,965,368...79,994,544
JBrowse link
G Exosc4 exosome component 4 increases expression ISO Clozapine results in increased expression of EXOSC4 protein CTD PMID:34122009 NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573
JBrowse link
G Ezr ezrin decreases expression ISO Clozapine results in decreased expression of EZR protein CTD PMID:34122009 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Clozapine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fan1 FANCD2 and FANCI associated nuclease 1 increases expression ISO Clozapine results in increased expression of FAN1 protein CTD PMID:34122009 NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977
JBrowse link
G Farsa phenylalanyl-tRNA synthetase subunit alpha increases expression ISO Clozapine results in increased expression of FARSA protein CTD PMID:34122009 NCBI chr19:23,291,409...23,300,985
Ensembl chr19:23,268,869...23,300,980
JBrowse link
G Farsb phenylalanyl-tRNA synthetase subunit beta increases expression ISO Clozapine results in increased expression of FARSB protein CTD PMID:34122009 NCBI chr 9:79,887,852...79,947,082
Ensembl chr 9:79,887,842...79,947,045
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA CTD PMID:20564506 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions ISO [Clozapine analog co-treated with Hydrogen Peroxide] results in increased expression of FASLG mRNA; [Clozapine co-treated with Hydrogen Peroxide co-treated with Tretinoin] results in increased expression of FASLG mRNA CTD PMID:16510162 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase increases expression ISO Clozapine results in increased expression of FASN mRNA CTD PMID:16027736 PMID:17052361 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression ISO Clozapine results in increased expression of FDPS mRNA CTD PMID:17052361 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Fen1 flap structure-specific endonuclease 1 increases expression ISO Clozapine results in increased expression of FEN1 protein CTD PMID:34122009 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression EXP Clozapine results in increased expression of FGF2 mRNA CTD PMID:11264663 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fhod1 formin homology 2 domain containing 1 decreases expression ISO Clozapine results in decreased expression of FHOD1 protein CTD PMID:34122009 NCBI chr19:33,206,492...33,225,448
Ensembl chr19:33,206,492...33,225,356
JBrowse link
G Fkbp8 FKBP prolyl isomerase 8 decreases expression ISO Clozapine results in decreased expression of FKBP8 protein CTD PMID:34122009 NCBI chr16:18,895,608...18,902,648
Ensembl chr16:18,893,576...18,902,612
JBrowse link
G Flot2 flotillin 2 increases expression ISO Clozapine results in increased expression of FLOT2 protein CTD PMID:34122009 NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases metabolic processing ISO FMO1 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Clozapine CTD PMID:18809730 PMID:27320963 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Clozapine results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases expression
EXP
ISO
Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA]
Clozapine results in increased expression of FOS protein
Clozapine analog results in increased expression of FOS protein; Clozapine results in increased expression of FOS mRNA; Clozapine results in increased expression of FOS protein
Clozapine results in decreased expression of FOS protein
CTD PMID:10435392 PMID:11166331 PMID:11440804 PMID:11997696 PMID:12093589 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
decreases expression
ISO
EXP
Clozapine results in increased expression of FOSB protein alternative form
Clozapine results in increased expression of FOSB mRNA; Clozapine results in increased expression of FOSB protein
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
Clozapine results in decreased expression of FOSB mRNA
CTD PMID:11259127 PMID:12093589 PMID:12243769 PMID:15579174 PMID:19695244 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression EXP Clozapine results in increased expression of FOSL1 mRNA CTD PMID:18208916 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression EXP Clozapine results in increased expression of FOSL2 mRNA CTD PMID:12093589 PMID:12243769 NCBI chr 6:24,297,898...24,319,157
Ensembl chr 6:24,300,956...24,320,034
JBrowse link
G Foxp2 forkhead box P2 increases expression ISO Clozapine results in increased expression of FOXP2 mRNA CTD PMID:17266109 NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683
JBrowse link
G Fstl1 follistatin-like 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of FSTL1 protein CTD PMID:34122009 NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
JBrowse link
G Fubp1 far upstream element binding protein 1 increases expression ISO Clozapine results in increased expression of FUBP1 protein CTD PMID:34122009 NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases expression ISO Clozapine results in decreased expression of G6PD protein CTD PMID:34122009 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 decreases expression ISO Clozapine results in decreased expression of GABBR1 mRNA CTD PMID:17266109 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases expression ISO Clozapine results in increased expression of GABRA1 mRNA CTD PMID:17266109 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases expression EXP Clozapine results in increased expression of GABRB3 mRNA CTD PMID:18923069 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression
decreases methylation
multiple interactions
ISO
EXP
Clozapine results in increased expression of GAD1 mRNA
Clozapine results in decreased methylation of GAD1 promoter
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]; Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter]
CTD PMID:12887421 PMID:15061247 PMID:17942719 PMID:18757738 PMID:18923069 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression ISO
EXP
Clozapine results in increased expression of GAD2 mRNA CTD PMID:17266109 PMID:18923069 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression EXP
ISO
Clozapine results in increased expression of GAPDH mRNA
Clozapine results in increased expression of GAPDH protein
CTD PMID:15860345 PMID:34122009 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase increases expression ISO Clozapine results in increased expression of GART protein CTD PMID:34122009 NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125
JBrowse link
G Gatm glycine amidinotransferase increases expression ISO Clozapine results in increased expression of GATM protein CTD PMID:34122009 NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129
JBrowse link
G Gcc2 GRIP and coiled-coil domain containing 2 decreases expression ISO Clozapine results in decreased expression of GCC2 protein CTD PMID:34122009 NCBI chr20:26,247,394...26,293,613
Ensembl chr20:26,247,404...26,293,613
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Clozapine results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression
EXP Clozapine results in decreased expression of GFAP protein
Clozapine results in increased expression of GFAP mRNA
CTD PMID:18585900 PMID:19441803 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ghitm growth hormone inducible transmembrane protein increases expression ISO Clozapine results in increased expression of GHITM protein CTD PMID:34122009 NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879
JBrowse link
G Gimap5 GTPase, IMAP family member 5 decreases expression EXP Clozapine results in decreased expression of GIMAP5 mRNA CTD PMID:16715494 NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086
JBrowse link
G Gip gastric inhibitory polypeptide increases expression EXP Clozapine results in increased expression of GIP mRNA; Clozapine results in increased expression of GIP protein CTD PMID:16402076 NCBI chr10:80,968,410...80,976,506
Ensembl chr10:80,968,352...80,976,503
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Clozapine results in increased expression of GJA1 protein CTD PMID:18585900 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Glrx3 glutaredoxin 3 increases expression ISO Clozapine results in increased expression of GLRX3 protein CTD PMID:34122009 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
JBrowse link
G Gna12 G protein subunit alpha 12 decreases expression
increases expression
EXP
ISO
Clozapine results in decreased expression of GNA12 mRNA
Clozapine results in increased expression of GNA12 protein
CTD PMID:15860345 PMID:34122009 NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255
JBrowse link
G Gnai1 G protein subunit alpha i1 decreases expression EXP Clozapine results in decreased expression of GNAI1 mRNA CTD PMID:15860345 NCBI chr 4:16,813,941...16,898,111
Ensembl chr 4:16,814,001...16,896,417
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP Clozapine results in decreased expression of GNAI2 mRNA CTD PMID:15860345 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gnai3 G protein subunit alpha i3 decreases expression EXP Clozapine results in decreased expression of GNAI3 mRNA CTD PMID:15860345 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
JBrowse link
G Gnas GNAS complex locus decreases expression
multiple interactions
increases expression
EXP
ISO
Clozapine results in decreased expression of GNAS mRNA
[Cuprizone co-treated with Clozapine] results in decreased expression of GNAS protein
Clozapine results in increased expression of GNAS protein
CTD PMID:15860345 PMID:34122009 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gnb3 G protein subunit beta 3 decreases response to substance
increases expression
affects response to substance
increases response to substance
ISO
EXP
GNB3 gene polymorphism results in decreased susceptibility to Clozapine
Clozapine results in increased expression of GNB3 protein
GNB3 protein affects the susceptibility to Clozapine
GNB3 gene polymorphism results in increased susceptibility to Clozapine
CTD PMID:16139171 PMID:16141801 PMID:18855531 NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173
JBrowse link
G Golga3 golgin A3 increases expression ISO Clozapine results in increased expression of GOLGA3 protein CTD PMID:34122009 NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509
JBrowse link
G Golgb1 golgin B1 increases expression ISO Clozapine results in increased expression of GOLGB1 protein CTD PMID:34122009 NCBI chr11:63,843,179...63,900,665
Ensembl chr11:63,843,986...63,900,770
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression
multiple interactions
EXP
ISO
Clozapine results in increased expression of GOT2 mRNA
[Cuprizone co-treated with Clozapine] results in increased expression of GOT2 protein
CTD PMID:15860345 PMID:34122009 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 decreases expression ISO Clozapine results in decreased expression of GPD2 protein CTD PMID:34122009 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
JBrowse link
G Gpi glucose-6-phosphate isomerase increases expression ISO Clozapine results in increased expression of GPI protein CTD PMID:34122009 NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Clozapine results in increased expression of GPX1 mRNA CTD PMID:14647396 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 increases expression EXP Clozapine results in increased expression of GRIK2 mRNA CTD PMID:18923069 NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375
JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 affects expression
decreases expression
ISO
EXP
Clozapine affects the expression of GRIK5 mRNA
Clozapine results in decreased expression of GRIK5 mRNA
CTD PMID:14647396 PMID:18923069 NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of GRIN1 mRNA
Clozapine results in increased expression of GRIN1 mRNA
CTD PMID:12020038 PMID:12608697 PMID:17266109 PMID:18923069 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression EXP Clozapine results in decreased expression of GRIN2A mRNA CTD PMID:12608697 PMID:18923069 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression EXP Clozapine results in decreased expression of GRIN2B mRNA CTD PMID:18923069 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C decreases expression EXP Clozapine results in decreased expression of GRIN2C mRNA CTD PMID:18923069 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 decreases expression EXP Clozapine results in decreased expression of GRK6 mRNA CTD PMID:16715494 NCBI chr17:9,177,018...9,192,644
Ensembl chr17:9,177,019...9,192,644
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression
multiple interactions
EXP Clozapine results in increased expression of GSK3A protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]
CTD PMID:16144542 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
increases expression
multiple interactions
ISO
EXP
Clozapine results in increased phosphorylation of GSK3B protein
Clozapine results in increased expression of GSK3B protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]
CTD PMID:16144542 PMID:19359144 PMID:19440698 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity
increases glutathionylation
ISO GSTA1 protein results in decreased activity of Clozapine
GSTA1 protein results in increased glutathionylation of Clozapine
CTD PMID:20849150 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity
increases expression
increases glutathionylation
ISO
EXP
GSTM1 protein results in decreased activity of Clozapine
Clozapine results in increased expression of GSTM1 mRNA
GSTM1 protein results in increased glutathionylation of Clozapine
CTD PMID:15860345 PMID:20849150 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Clozapine results in decreased expression of GSTM2 mRNA CTD PMID:15860345 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity
affects metabolic processing
increases glutathionylation
affects binding
ISO Clozapine metabolite results in decreased activity of GSTP1 protein; GSTP1 protein results in decreased activity of Clozapine
GSTP1 protein affects the metabolism of Clozapine metabolite
GSTP1 protein results in increased glutathionylation of Clozapine
Clozapine metabolite binds to GSTP1 protein
CTD PMID:20849150 PMID:21639118 PMID:24185126 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G H1f2 H1.2 linker histone, cluster member increases expression ISO Clozapine results in increased expression of H1-2 protein CTD PMID:34122009 NCBI chr17:41,391,106...41,392,611
Ensembl chr17:41,388,477...41,392,635
JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 increases expression ISO Clozapine results in increased expression of HACD3 protein CTD PMID:34122009 NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression ISO Clozapine results in increased expression of HADHB protein CTD PMID:34122009 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
JBrowse link
G Hars1 histidyl-tRNA synthetase 1 increases expression ISO Clozapine results in increased expression of HARS protein CTD PMID:34122009 NCBI chr18:28,381,649...28,398,699
Ensembl chr18:28,381,655...28,398,740
JBrowse link
G Hat1 histone acetyltransferase 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of HAT1 protein CTD PMID:34122009 NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517
JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of HCLS1 protein CTD PMID:34122009 NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014
JBrowse link
G Hdgfl2 HDGF like 2 increases expression ISO Clozapine results in increased expression of HDGFRP2 protein CTD PMID:34122009 NCBI chr 9:909,581...929,195
Ensembl chr 9:909,614...929,186
JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A increases expression ISO Clozapine results in increased expression of HIGD1A mRNA CTD PMID:14647396 NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443
JBrowse link
G Hist2h2aa2 histone cluster 2 H2A family member A2 increases expression ISO Clozapine results in increased expression of H2AC18 mRNA CTD PMID:14647396 NCBI chr 2:183,801,369...183,801,987 JBrowse link
G Hmgb2 high mobility group box 2 increases expression ISO Clozapine results in increased expression of HMGB2 protein CTD PMID:34122009 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
increases activity
ISO [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides
Clozapine results in increased expression of HMGCR mRNA
CTD PMID:16027736 PMID:17052361 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Clozapine results in increased expression of HMGCS1 mRNA CTD PMID:16027736 PMID:17052361 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Clozapine results in increased expression of HMOX1 mRNA CTD PMID:18227147 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D decreases expression ISO Clozapine results in decreased expression of HNRNPD protein CTD PMID:34122009 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
JBrowse link
G Homer1 homer scaffold protein 1 increases expression
multiple interactions
EXP Clozapine results in increased expression of HOMER1 mRNA
Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]
CTD PMID:12464447 PMID:15860345 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Hpcal1 hippocalcin-like 1 decreases expression EXP Clozapine results in decreased expression of HPCAL1 mRNA CTD PMID:12437575 NCBI chr 6:40,478,182...40,584,721
Ensembl chr 6:40,478,208...40,584,687
JBrowse link
G Hpcal4 hippocalcin-like 4 affects expression EXP Clozapine affects the expression of HPCAL4 mRNA CTD PMID:12437575 NCBI chr 5:135,454,477...135,466,417
Ensembl chr 5:135,454,540...135,466,416
JBrowse link
G Hpn hepsin increases expression ISO Clozapine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
JBrowse link
G Hrh1 histamine receptor H 1 affects binding ISO Clozapine binds to HRH1 protein CTD PMID:16983399 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Hrh3 histamine receptor H3 multiple interactions EXP Clozapine binds to Hrh3 protein; Clozapine inhibits the reaction [N-methylhistamine binds to Hrh3 protein] RGD PMID:10869375 RGD:632981 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression ISO Clozapine results in decreased expression of HSD17B10 protein CTD PMID:34122009 NCBI chr  X:21,089,152...21,091,597
Ensembl chr  X:21,089,122...21,109,488
JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 increases expression ISO Clozapine results in increased expression of HSD17B12 protein CTD PMID:34122009 NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 decreases expression ISO Clozapine results in decreased expression of HSPA9 protein CTD PMID:34122009 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
affects binding
ISO
EXP
Clozapine binds to and affects the activity of HTR1A protein
Clozapine binds to HTR1A protein
CTD PMID:9723970 PMID:15482641 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D decreases expression EXP Clozapine results in decreased expression of HTR1D mRNA CTD PMID:16715494 NCBI chr 5:148,655,979...148,676,534
Ensembl chr 5:148,674,495...148,675,619
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases response to substance
affects binding
multiple interactions
decreases expression
decreases activity
affects response to substance
increases expression
ISO
EXP
HTR2A gene SNP results in increased susceptibility to Clozapine
Clozapine analog binds to HTR2A protein; Clozapine binds to HTR2A protein
Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]
Clozapine results in decreased expression of HTR2A mRNA; Clozapine results in decreased expression of HTR2A protein
Clozapine results in decreased activity of HTR2A protein
[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]; Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein]
HTR2A protein affects the susceptibility to Clozapine
Clozapine results in increased expression of HTR2A mRNA
CTD PMID:7520908 PMID:9723970 PMID:11997696 PMID:14751426 PMID:15380371 More... NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding
decreases expression
affects response to substance
ISO
EXP
Clozapine binds to HTR2C protein
Clozapine results in decreased expression of HTR2C mRNA
HTR2C gene polymorphism affects the susceptibility to Clozapine; HTR2C gene SNP affects the susceptibility to Clozapine; HTR2C promoter SNP affects the susceptibility to Clozapine; HTR2C protein affects the susceptibility to Clozapine
CTD PMID:9723970 PMID:12668355 PMID:15635667 PMID:16983399 PMID:17868938 More... NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
affects response to substance
ISO Clozapine binds to and results in decreased activity of HTR3A protein
HTR3A protein affects the susceptibility to Clozapine
CTD PMID:19696922 PMID:20168265 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 multiple interactions
affects binding
ISO Clozapine binds to and results in decreased activity of HTR6 protein
[Cuprizone co-treated with Clozapine] results in increased expression of HTR6 protein
Clozapine binds to HTR6 protein
CTD PMID:11406289 PMID:16983399 PMID:34122009 NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects binding
multiple interactions
ISO Clozapine binds to HTR7 protein
[Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD PMID:14578406 PMID:20827463 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression EXP Clozapine results in increased expression of ID2 mRNA CTD PMID:12437575 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of IDH2 protein CTD PMID:34122009 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO Clozapine results in decreased expression of IDI1 protein CTD PMID:34122009 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Ifng interferon gamma affects expression
decreases expression
ISO Clozapine affects the expression of IFNG protein
Clozapine results in decreased expression of IFNG mRNA
CTD PMID:17346280 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO Clozapine results in decreased expression of IGF1 protein CTD PMID:11769361 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il10 interleukin 10 decreases expression EXP Clozapine results in decreased expression of IL10 protein CTD PMID:24709159 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
EXP Clozapine results in increased secretion of IL1B protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of IL1B protein]
CTD PMID:34935985 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases secretion ISO Clozapine results in increased secretion of IL2RA protein CTD PMID:8067274 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
G Il5 interleukin 5 affects expression ISO Clozapine affects the expression of IL5 protein CTD PMID:17346280 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Ilkap ILK associated serine/threonine phosphatase decreases expression EXP Clozapine results in decreased expression of ILKAP mRNA CTD PMID:15860345 NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892
JBrowse link
G Inha inhibin subunit alpha decreases expression EXP Clozapine results in decreased expression of INHA mRNA CTD PMID:16715494 NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Clozapine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:63,177,558...63,178,983
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Ins2 insulin 2 affects secretion
increases expression
ISO Clozapine affects the secretion of INS protein
Clozapine results in increased expression of INS protein
CTD PMID:11769361 PMID:16601995 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Itga6 integrin subunit alpha 6 increases expression ISO Clozapine results in increased expression of ITGA6 protein CTD PMID:34122009 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein] CTD PMID:18976543 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression
EXP Clozapine results in decreased expression of JUN mRNA
Clozapine results in increased expression of JUN mRNA
CTD PMID:12093589 PMID:15860345 PMID:18208916 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Clozapine results in increased expression of JUNB mRNA CTD PMID:12093589 PMID:19695244 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Clozapine results in decreased expression of JUND mRNA CTD PMID:12093589 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Kcna1 potassium voltage-gated channel subfamily A member 1 increases expression ISO Clozapine results in increased expression of KCNA1 mRNA CTD PMID:18797397 NCBI chr 4:159,464,223...159,472,905
Ensembl chr 4:159,464,188...159,472,682
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Clozapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 decreases expression
increases expression
ISO Clozapine results in decreased expression of KCNIP3 mRNA
Clozapine results in increased expression of KCNIP3 mRNA
CTD PMID:17266109 PMID:18797397 NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 decreases expression ISO Clozapine results in decreased expression of KCNK2 mRNA CTD PMID:15542763 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435
JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression ISO Clozapine results in decreased expression of KCTD12 protein CTD PMID:34122009 NCBI chr15:79,800,077...79,806,064
Ensembl chr15:79,801,191...79,806,282
JBrowse link
G Kdr kinase insert domain receptor increases expression ISO Clozapine results in increased expression of KDR protein CTD PMID:34122009 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Khdrbs1 KH RNA binding domain containing, signal transduction associated 1 decreases expression ISO Clozapine results in decreased expression of KHDRBS1 protein CTD PMID:34122009 NCBI chr 5:142,051,844...142,089,175
Ensembl chr 5:142,063,570...142,089,180
JBrowse link
G Kif13b kinesin family member 13B increases expression ISO Clozapine results in increased expression of KIF13B protein CTD PMID:34122009 NCBI chr15:38,908,318...39,062,849
Ensembl chr15:38,924,624...39,084,879
JBrowse link
G Kif5c kinesin family member 5C decreases expression ISO Clozapine results in decreased expression of KIF5C protein CTD PMID:34122009 NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413
JBrowse link
G Kiz kizuna centrosomal protein multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of KIZ protein CTD PMID:34122009 NCBI chr 3:134,277,631...134,385,260
Ensembl chr 3:134,277,687...134,385,190
JBrowse link
G Klhdc2 kelch domain containing 2 decreases expression ISO Clozapine results in decreased expression of KLHDC2 protein CTD PMID:34122009 NCBI chr 6:87,777,183...87,791,609
Ensembl chr 6:87,777,183...87,804,187
JBrowse link
G Kmt2a lysine methyltransferase 2A increases expression
decreases expression
multiple interactions
ISO Clozapine results in increased expression of KMT2A mRNA
Clozapine results in decreased expression of KMT2A mRNA
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]
CTD PMID:14647396 PMID:17942719 NCBI chr 8:45,116,771...45,193,320
Ensembl chr 8:45,118,814...45,193,181
JBrowse link
G Kpna4 karyopherin subunit alpha 4 multiple interactions
increases expression
ISO [Cuprizone co-treated with Clozapine] results in increased expression of KPNA4 protein
Clozapine results in increased expression of KPNA4 protein
CTD PMID:34122009 NCBI chr 2:153,319,380...153,381,085
Ensembl chr 2:153,324,273...153,381,081
JBrowse link
G Kremen1 kringle containing transmembrane protein 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of KREMEN1 protein CTD PMID:34122009 NCBI chr14:80,081,870...80,147,489
Ensembl chr14:80,084,403...80,147,516
JBrowse link
G Lactb2 lactamase, beta 2 increases expression ISO Clozapine results in increased expression of LACTB2 protein CTD PMID:34122009 NCBI chr 5:5,569,080...5,591,843
Ensembl chr 5:5,569,067...5,596,429
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 increases expression ISO Clozapine results in increased expression of LAMP1 protein CTD PMID:34122009 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 increases expression ISO Clozapine results in increased expression of LAMTOR3 mRNA CTD PMID:14647396 NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607
JBrowse link
G Larp7 La ribonucleoprotein 7, transcriptional regulator increases expression ISO Clozapine results in increased expression of LARP7 protein CTD PMID:34122009 NCBI chr 2:215,997,641...216,012,833
Ensembl chr 2:215,997,649...216,012,865
JBrowse link
G Lcn1 lipocalin 1 decreases expression ISO Clozapine results in decreased expression of LCN1 protein CTD PMID:34122009 NCBI chr 3:9,532,860...9,537,859
Ensembl chr 3:9,532,915...9,536,577
JBrowse link
G Ldhb lactate dehydrogenase B increases expression EXP Clozapine results in increased expression of LDHB mRNA CTD PMID:15860345 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
JBrowse link
G Ldlr low density lipoprotein receptor increases expression
multiple interactions
ISO Clozapine results in increased expression of LDLR mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]
CTD PMID:17052361 PMID:20564506 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Leap2 liver enriched antimicrobial peptide 2 increases expression ISO Clozapine results in increased expression of LEAP2 mRNA CTD PMID:17346280 NCBI chr10:37,577,855...37,581,245
Ensembl chr10:37,577,855...37,581,244
JBrowse link
G Lemd2 LEM domain nuclear envelope protein 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of LEMD2 protein CTD PMID:34122009 NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626
JBrowse link
G Lep leptin affects response to substance
increases expression
ISO
EXP
LEP protein affects the susceptibility to Clozapine
Clozapine results in increased expression of LEP protein
CTD PMID:16402076 PMID:17502770 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lipa lipase A, lysosomal acid type increases expression ISO Clozapine results in increased expression of LIPA protein CTD PMID:34122009 NCBI chr 1:232,024,351...232,167,329
Ensembl chr 1:232,024,356...232,057,633
JBrowse link
G Lmod2 leiomodin 2 increases expression ISO Clozapine results in increased expression of LMOD2 protein CTD PMID:34122009 NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120
JBrowse link
G LOC100361265 rCG64283-like increases expression ISO Clozapine results in increased expression of CXORF49 protein CTD PMID:34122009 NCBI chr  X:66,911,430...66,915,407
Ensembl chr  X:66,911,431...66,915,293
JBrowse link
G Lpl lipoprotein lipase decreases expression
increases expression
ISO Clozapine results in decreased expression of LPL mRNA; Clozapine results in decreased expression of LPL protein
Clozapine results in increased expression of LPL mRNA
CTD PMID:17266109 PMID:19682446 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing increases expression ISO Clozapine results in increased expression of LRPPRC protein CTD PMID:34122009 NCBI chr 6:9,859,867...9,942,294
Ensembl chr 6:9,859,867...9,942,293
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 increases expression ISO Clozapine results in increased expression of LRRK2 protein CTD PMID:34122009 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Lss lanosterol synthase increases expression
multiple interactions
ISO Clozapine results in increased expression of LSS mRNA
[Cuprizone co-treated with Clozapine] results in decreased expression of LSS protein
CTD PMID:15342952 PMID:17175557 PMID:34122009 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Lta4h leukotriene A4 hydrolase decreases expression ISO Clozapine results in decreased expression of LTA4H protein CTD PMID:34122009 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
JBrowse link
G Magt1 magnesium transporter 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MAGT1 protein CTD PMID:34122009 NCBI chr  X:71,038,489...71,079,704
Ensembl chr  X:71,038,489...71,079,699
JBrowse link
G Mal mal, T-cell differentiation protein decreases expression ISO Clozapine results in decreased expression of MAL mRNA CTD PMID:17266109 PMID:18797397 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
JBrowse link
G Maob monoamine oxidase B increases expression ISO Clozapine results in increased expression of MAOB mRNA CTD PMID:17266109 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Map1a microtubule-associated protein 1A increases expression
decreases expression
EXP
ISO
Clozapine results in increased expression of MAP1A mRNA
Clozapine results in decreased expression of MAP1A protein
CTD PMID:15860345 PMID:34122009 NCBI chr 3:108,263,217...108,283,936
Ensembl chr 3:108,263,151...108,282,899
JBrowse link
G Map1b microtubule-associated protein 1B decreases expression ISO Clozapine results in decreased expression of MAP1B protein CTD PMID:34122009 NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
JBrowse link
G Map1s microtubule-associated protein 1S increases expression ISO Clozapine results in increased expression of MAP1S protein CTD PMID:34122009 NCBI chr16:18,516,759...18,527,777
Ensembl chr16:18,517,574...18,527,988
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases expression EXP Clozapine results in decreased expression of MAP2K1 mRNA CTD PMID:15860345 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases expression
decreases expression
ISO
EXP
Clozapine results in increased expression of MAP2K2 mRNA
Clozapine results in decreased expression of MAP2K2 mRNA
CTD PMID:14647396 PMID:15860345 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 decreases expression EXP Clozapine results in decreased expression of MAP2K5 mRNA CTD PMID:15860345 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression EXP Clozapine results in increased expression of MAP3K1 mRNA CTD PMID:15860345 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 increases expression EXP Clozapine results in increased expression of MAP3K12 mRNA CTD PMID:15860345 NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation
ISO
EXP
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]
Clozapine results in decreased expression of MAPK1 mRNA
Clozapine results in decreased phosphorylation of MAPK1 protein
CTD PMID:12871586 PMID:15860345 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects expression EXP Clozapine affects the expression of MAPK14 mRNA CTD PMID:15860345 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO Clozapine results in decreased phosphorylation of MAPK3 protein
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]
CTD PMID:12871586 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 affects expression EXP Clozapine affects the expression of MAPK6 mRNA CTD PMID:15860345 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 increases expression ISO Clozapine results in increased expression of MAPK8IP1 mRNA CTD PMID:17266109 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 affects expression EXP Clozapine affects the expression of MAPK9 mRNA CTD PMID:15860345 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapre1 microtubule-associated protein, RP/EB family, member 1 decreases expression
multiple interactions
ISO Clozapine results in decreased expression of MAPRE1 protein
[Cuprizone co-treated with Clozapine] results in decreased expression of MAPRE1 protein
CTD PMID:34122009 NCBI chr 3:142,218,846...142,246,990
Ensembl chr 3:142,212,955...142,246,983
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor decreases expression EXP Clozapine results in decreased expression of MAS1 mRNA CTD PMID:16715494 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
JBrowse link
G Mat2a methionine adenosyltransferase 2A decreases expression ISO Clozapine results in decreased expression of MAT2A protein CTD PMID:34122009 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493
JBrowse link
G Mat2b methionine adenosyltransferase 2B decreases expression ISO Clozapine results in decreased expression of MAT2B protein CTD PMID:34122009 NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777
JBrowse link
G Mbp myelin basic protein increases expression ISO Clozapine results in increased expression of MBP mRNA CTD PMID:17266109 PMID:17346280 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mc1r melanocortin 1 receptor increases expression ISO Clozapine results in increased expression of MC1R mRNA CTD PMID:17346280 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MDC1 protein CTD PMID:34122009 NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
JBrowse link
G Mdh1 malate dehydrogenase 1 decreases expression ISO Clozapine results in decreased expression of MDH1 protein CTD PMID:34122009 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase increases expression ISO Clozapine results in increased expression of MLKL protein CTD PMID:31220554 NCBI chr19:39,278,123...39,304,555
Ensembl chr19:39,276,785...39,304,502
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Clozapine results in decreased expression of MMP10 mRNA CTD PMID:17346280 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO Clozapine results in decreased expression of MMP7 mRNA CTD PMID:17346280 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mobp myelin-associated oligodendrocyte basic protein increases expression ISO Clozapine results in increased expression of MOBP mRNA CTD PMID:15542763 PMID:17266109 NCBI chr 8:119,869,504...119,899,605
Ensembl chr 8:119,869,626...119,899,563
JBrowse link
G Mpo myeloperoxidase affects response to substance ISO MPO protein affects the susceptibility to Clozapine CTD PMID:24588327 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mpp3 MAGUK p55 scaffold protein 3 decreases expression ISO Clozapine results in decreased expression of MPP3 mRNA CTD PMID:17266109 NCBI chr10:86,945,705...86,975,261
Ensembl chr10:86,945,714...86,974,737
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Clozapine affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
JBrowse link
G Mta2 metastasis associated 1 family, member 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MTA2 protein CTD PMID:34122009 NCBI chr 1:205,838,181...205,846,903
Ensembl chr 1:205,837,964...205,846,946
JBrowse link
G Mtdh metadherin multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MTDH protein CTD PMID:34122009 NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413
JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR gene polymorphism affects the susceptibility to Clozapine; MTHFR protein affects the susceptibility to Clozapine CTD PMID:20547447 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Myadm myeloid-associated differentiation marker multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MYADM protein CTD PMID:34122009 NCBI chr 1:65,864,180...65,874,701
Ensembl chr 1:65,864,173...65,874,035
JBrowse link
G Mybbp1a MYB binding protein 1a increases expression ISO Clozapine results in increased expression of MYBBP1A protein CTD PMID:34122009 NCBI chr10:57,056,913...57,067,263
Ensembl chr10:57,056,874...57,067,255
JBrowse link
G Myh10 myosin heavy chain 10 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MYH10 protein CTD PMID:34122009 NCBI chr10:53,393,901...53,525,174
Ensembl chr10:53,394,389...53,525,165
JBrowse link
G Myh3 myosin heavy chain 3 increases expression ISO Clozapine results in increased expression of MYH3 protein CTD PMID:34122009 NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992
JBrowse link
G Myl1 myosin, light chain 1 increases expression ISO Clozapine results in increased expression of MYL1 protein CTD PMID:34122009 NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261
JBrowse link
G Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit decreases expression ISO Clozapine results in decreased expression of NAA10 protein CTD PMID:34122009 NCBI chr  X:151,656,056...151,661,304
Ensembl chr  X:151,656,056...151,661,252
JBrowse link
G Nap1l4 nucleosome assembly protein 1-like 4 increases expression ISO Clozapine results in increased expression of NAP1L4 protein CTD PMID:34122009 NCBI chr 1:198,709,697...198,746,093
Ensembl chr 1:198,709,701...198,746,020
JBrowse link
G Nat10 N-acetyltransferase 10 decreases expression ISO Clozapine results in decreased expression of NAT10 protein CTD PMID:34122009 NCBI chr 3:90,111,643...90,151,644
Ensembl chr 3:90,111,645...90,149,927
JBrowse link
G Ncan neurocan decreases expression ISO Clozapine results in decreased expression of NCAN mRNA CTD PMID:18797397 NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436
JBrowse link
G Ncapg non-SMC condensin I complex, subunit G increases expression ISO Clozapine results in increased expression of NCAPG protein CTD PMID:34122009 NCBI chr14:65,404,235...65,432,902
Ensembl chr14:65,404,163...65,432,902
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H decreases expression ISO Clozapine results in decreased expression of NCAPH protein CTD PMID:34122009 NCBI chr 3:114,371,937...114,399,223
Ensembl chr 3:114,371,941...114,399,180
JBrowse link
G Ncbp1 nuclear cap binding protein subunit 1 decreases expression ISO Clozapine results in decreased expression of NCBP1 protein CTD PMID:34122009 NCBI chr 5:60,416,023...60,449,004
Ensembl chr 5:60,415,982...60,449,089
JBrowse link
G Ncl nucleolin increases expression ISO Clozapine results in increased expression of NCL mRNA CTD PMID:14647396 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression EXP Clozapine results in increased expression of NDUFV2 mRNA CTD PMID:19441803 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 decreases expression ISO Clozapine results in decreased expression of NECTIN2 protein CTD PMID:34122009 NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase decreases expression ISO Clozapine results in decreased expression of NEDD4 mRNA CTD PMID:18797397 NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951
JBrowse link
G Nes nestin decreases expression ISO Clozapine results in decreased expression of NES protein CTD PMID:34122009 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to Clozapine CTD PMID:21540358 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression EXP Clozapine results in decreased expression of NFKB1 protein CTD PMID:16500086 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Ngfr nerve growth factor receptor decreases expression ISO
EXP
Clozapine results in decreased expression of NGFR protein; Clozapine results in decreased expression of NGFR protein alternative form
Clozapine results in decreased expression of NGFR mRNA
CTD PMID:12111809 PMID:14598305 PMID:16513140 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nifk nucleolar protein interacting with the FHA domain of MKI67 decreases expression ISO Clozapine results in decreased expression of NIFK protein CTD PMID:34122009 NCBI chr13:29,393,303...29,403,387
Ensembl chr13:29,393,286...29,405,896
JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression ISO Clozapine results in increased expression of NNMT protein CTD PMID:34122009 NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655
JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression ISO Clozapine results in decreased expression of NNT protein CTD PMID:34122009 NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
JBrowse link
G Noc2l NOC2-like nucleolar associated transcriptional repressor increases expression ISO Clozapine results in increased expression of NOC2L protein CTD PMID:34122009 NCBI chr 5:166,820,075...166,831,951
Ensembl chr 5:166,820,161...166,831,949
JBrowse link
G Nop53 NOP53 ribosome biogenesis factor affects expression ISO Clozapine affects the expression of NOP53 mRNA CTD PMID:14647396 NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor decreases expression ISO Clozapine results in decreased expression of NPLOC4 protein CTD PMID:34122009 NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913
JBrowse link
G Nptn neuroplastin increases expression ISO Clozapine results in increased expression of NPTN mRNA CTD PMID:18797397 NCBI chr 8:58,996,876...59,063,402
Ensembl chr 8:58,996,887...59,063,401
JBrowse link
G Nptx2 neuronal pentraxin 2 decreases expression EXP Clozapine results in decreased expression of NPTX2 mRNA CTD PMID:18208916 NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345
JBrowse link
G Npy neuropeptide Y decreases expression EXP Clozapine results in decreased expression of NPY mRNA CTD PMID:16516965 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 affects response to substance
increases reduction
multiple interactions
ISO NQO2 gene SNP affects the susceptibility to Clozapine
NQO2 protein results in increased reduction of Clozapine metabolite
Clozapine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3]
CTD PMID:14617031 PMID:29281794 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Clozapine results in increased expression of NR0B2 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] CTD PMID:21402137 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Clozapine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein] CTD PMID:16581232 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
decreases expression
EXP Clozapine results in increased expression of NR4A1 mRNA
Clozapine results in decreased expression of NR4A1 mRNA
CTD PMID:10987852 PMID:11564422 PMID:19695244 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Clozapine results in increased expression of NR4A2 mRNA CTD PMID:17266109 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Nrg1 neuregulin 1 increases expression
affects expression
affects response to substance
ISO
EXP
Clozapine results in increased expression of NRG1 mRNA
Clozapine affects the expression of NRG1 protein
NRG1 protein affects the susceptibility to Clozapine
CTD PMID:15706234 PMID:18184445 PMID:19502011 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase decreases expression ISO Clozapine results in decreased expression of NSF protein CTD PMID:34122009 NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
JBrowse link
G Ntng2 netrin G2 increases expression EXP Clozapine results in increased expression of NTNG2 mRNA CTD PMID:17507910 NCBI chr 3:12,492,574...12,551,104
Ensembl chr 3:12,492,639...12,545,890
JBrowse link
G Nts neurotensin increases expression EXP Clozapine results in increased expression of NTS mRNA CTD PMID:12887421 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
JBrowse link
G Nudt10 nudix hydrolase 10 increases expression ISO Clozapine results in increased expression of NUDT10 protein CTD PMID:34122009
G Numa1 nuclear mitotic apparatus protein 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of NUMA1 protein CTD PMID:34122009 NCBI chr 1:156,297,907...156,372,855
Ensembl chr 1:156,326,259...156,372,855
JBrowse link
G Numbl NUMB-like, endocytic adaptor protein decreases expression ISO Clozapine results in decreased expression of NUMBL mRNA CTD PMID:18797397 NCBI chr 1:82,549,814...82,573,788
Ensembl chr 1:82,550,054...82,573,776
JBrowse link
G Nup160 nucleoporin 160 increases expression ISO Clozapine results in increased expression of NUP160 protein CTD PMID:34122009 NCBI chr 3:76,665,786...76,729,296
Ensembl chr 3:76,665,786...76,724,565
JBrowse link
G Nup50 nucleoporin 50 increases expression ISO Clozapine results in increased expression of NUP50 protein CTD PMID:34122009 NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905
JBrowse link
G Nup54 nucleoporin 54 decreases expression ISO Clozapine results in decreased expression of NUP54 protein CTD PMID:34122009 NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Clozapine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Osbpl8 oxysterol binding protein-like 8 increases expression ISO Clozapine results in increased expression of OSBPL8 mRNA CTD PMID:14647396 NCBI chr 7:46,596,944...46,749,888
Ensembl chr 7:46,596,983...46,749,888
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide affects response to substance ISO OXT protein affects the susceptibility to Clozapine CTD PMID:20196918 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G Pank3 pantothenate kinase 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of PANK3 protein CTD PMID:34122009 NCBI chr10:20,229,129...20,252,955
Ensembl chr10:20,229,129...20,252,955
JBrowse link
G Park7 Parkinsonism associated deglycase increases expression ISO Clozapine results in increased expression of PARK7 mRNA CTD PMID:14647396 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Pcbp1 poly(rC) binding protein 1 increases expression ISO Clozapine results in increased expression of PCBP1 protein CTD PMID:34122009 NCBI chr 4:118,972,698...118,974,722
Ensembl chr 4:118,972,661...118,976,500
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) decreases expression ISO Clozapine results in decreased expression of PCK2 protein CTD PMID:34122009 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
JBrowse link
G Pclo piccolo (presynaptic cytomatrix protein) multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of PCLO protein CTD PMID:34122009 NCBI chr 4:19,691,439...20,050,015
Ensembl chr 4:19,695,315...20,049,885
JBrowse link
G Pcm1 pericentriolar material 1 decreases expression ISO Clozapine results in decreased expression of PCM1 mRNA CTD PMID:19048012 NCBI chr16:51,008,315...51,105,261
Ensembl chr16:51,008,315...51,105,091
JBrowse link
G Pcnp PEST proteolytic signal containing nuclear protein increases expression ISO Clozapine results in increased expression of PCNP protein CTD PMID:34122009 NCBI chr11:44,592,766...44,607,372
Ensembl chr11:44,592,742...44,607,348
JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor affects expression ISO Clozapine affects the expression of PCSK1N mRNA CTD PMID:14647396 NCBI chr  X:14,580,036...14,583,478
Ensembl chr  X:14,580,038...14,583,566
JBrowse link
G Pdcd11 programmed cell death 11 increases expression ISO Clozapine results in increased expression of PDCD11 protein CTD PMID:34122009 NCBI chr 1:245,980,840...246,021,999
Ensembl chr 1:245,980,880...246,021,999
JBrowse link
G Pde10a phosphodiesterase 10A increases expression ISO
EXP
Clozapine results in increased expression of PDE10A mRNA
Clozapine results in increased expression of PDE10A mRNA; Clozapine results in increased expression of PDE10A protein
CTD PMID:17266109 PMID:18222493 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563
JBrowse link
G Pde1b phosphodiesterase 1B increases expression ISO Clozapine results in increased expression of PDE1B mRNA CTD PMID:14647396 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580
JBrowse link
G Pde4a phosphodiesterase 4A decreases expression EXP Clozapine results in decreased expression of PDE4A protein CTD PMID:20222156 NCBI chr 8:19,706,649...19,751,937
Ensembl chr 8:19,703,290...19,751,961
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression
increases expression
EXP Clozapine results in decreased expression of PDE4B protein
Clozapine results in increased expression of PDE4B mRNA; Clozapine results in increased expression of PDE4B protein
CTD PMID:18222493 PMID:20222156 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression ISO Clozapine results in decreased expression of PDIA3 protein CTD PMID:34122009 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of PDIA4 protein CTD PMID:34122009 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107
JBrowse link
G Pdlim5 PDZ and LIM domain 5 decreases expression ISO Clozapine results in decreased expression of PDLIM5 protein CTD PMID:34122009 NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275
JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 decreases expression ISO Clozapine results in decreased expression of PEBP1 protein CTD PMID:34122009 NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
JBrowse link
G Penk proenkephalin decreases expression
increases expression
EXP Clozapine results in decreased expression of PENK mRNA
Clozapine results in increased expression of PENK mRNA
CTD PMID:1635659 PMID:12887421 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Pfdn5 prefoldin subunit 5 increases expression ISO Clozapine results in increased expression of PFDN5 mRNA CTD PMID:14647396 NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516
JBrowse link
G Pfkp phosphofructokinase, platelet increases expression EXP Clozapine results in increased expression of PFKP mRNA CTD PMID:15860345 NCBI chr17:63,729,743...63,794,021
Ensembl chr17:63,729,780...63,794,018
JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase decreases expression ISO Clozapine results in decreased expression of PGAM5 protein CTD PMID:34122009 NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression EXP Clozapine results in increased expression of PGK1 mRNA CTD PMID:15860345 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Phactr1 phosphatase and actin regulator 1 increases expression ISO Clozapine results in increased expression of PHACTR1 mRNA CTD PMID:14647396 NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831
JBrowse link
G Phf14 PHD finger protein 14 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of PHF14 protein CTD PMID:34122009 NCBI chr 4:40,009,691...40,195,870
Ensembl chr 4:40,009,264...40,195,885
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 decreases expression EXP Clozapine results in decreased expression of PIK3R3 mRNA CTD PMID:16715494 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
JBrowse link
G Pitpnb phosphatidylinositol transfer protein, beta increases expression ISO Clozapine results in increased expression of PITPNB protein CTD PMID:34122009 NCBI chr12:45,249,308...45,298,388
Ensembl chr12:45,249,333...45,298,314
JBrowse link
G Pkib cAMP-dependent protein kinase inhibitor beta decreases expression EXP Clozapine results in decreased expression of PKIB mRNA CTD PMID:15860345 NCBI chr20:36,965,172...37,062,190
Ensembl chr20:36,905,340...37,062,187
JBrowse link
G Pkm pyruvate kinase M1/2 increases expression EXP Clozapine results in increased expression of PKM mRNA CTD PMID:15860345 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Plcb1 phospholipase C beta 1 increases expression ISO Clozapine results in increased expression of PLCB1 mRNA CTD PMID:16465460 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Plp1 proteolipid protein 1 decreases expression
increases expression
ISO Clozapine results in decreased expression of PLP1 mRNA
Clozapine results in increased expression of PLP1 mRNA
CTD PMID:17266109 PMID:18797397 NCBI chr  X:100,184,039...100,201,035
Ensembl chr  X:100,185,767...100,201,032
JBrowse link
G Pls3 plastin 3 decreases expression ISO Clozapine results in decreased expression of PLS3 protein CTD PMID:34122009 NCBI chr  X:111,589,193...111,683,908
Ensembl chr  X:111,589,254...111,683,891
JBrowse link
G Pnma1 PNMA family member 1 increases expression ISO Clozapine results in increased expression of PNMA1 protein CTD PMID:34122009 NCBI chr 6:103,782,244...103,784,029
Ensembl chr 6:103,773,889...103,784,567
JBrowse link
G Pon3 paraoxonase 3 increases expression ISO Clozapine results in increased expression of PON3 protein CTD PMID:34122009 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
JBrowse link
G Ppa1 inorganic pyrophosphatase 1 increases expression ISO Clozapine results in increased expression of PPA1 protein CTD PMID:34122009 NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]
Clozapine results in increased expression of PPARG mRNA; Clozapine results in increased expression of PPARG protein
CTD PMID:20564506 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A decreases expression EXP Clozapine results in decreased expression of PPM1A mRNA CTD PMID:15860345 NCBI chr 6:91,439,094...91,486,139
Ensembl chr 6:91,438,834...91,480,697
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B decreases expression EXP Clozapine results in decreased expression of PPM1B mRNA CTD PMID:15860345 NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974
JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta decreases expression EXP Clozapine results in decreased expression of PPP1CB mRNA CTD PMID:15860345 NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824
JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma decreases expression EXP Clozapine results in decreased expression of PPP1CC mRNA CTD PMID:15860345 NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553
JBrowse link
G Ppp1r14b protein phosphatase 1, regulatory (inhibitor) subunit 14B decreases expression ISO Clozapine results in decreased expression of PPP1R14B protein CTD PMID:34122009 NCBI chr 1:204,165,210...204,167,320
Ensembl chr 1:204,163,299...204,167,319
JBrowse link
G Ppp1r1a protein phosphatase 1, regulatory (inhibitor) subunit 1A decreases expression EXP Clozapine results in decreased expression of PPP1R1A mRNA CTD PMID:15860345 NCBI chr 7:134,654,578...134,662,236
Ensembl chr 7:134,654,579...134,662,230
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions
increases phosphorylation
ISO Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]
Clozapine results in increased phosphorylation of PPP1R1B protein
CTD PMID:11880652 PMID:12871586 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
JBrowse link
G Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 decreases expression EXP Clozapine results in decreased expression of PPP1R2 mRNA CTD PMID:15860345 NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463
JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B increases expression EXP Clozapine results in increased expression of PPP1R9B protein CTD PMID:16844384 NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha decreases expression EXP Clozapine results in decreased expression of PPP2CA mRNA CTD PMID:15860345 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression EXP Clozapine results in decreased expression of PPP2CB mRNA CTD PMID:15860345 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression EXP Clozapine results in increased expression of PPP2R1A mRNA CTD PMID:15860345 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha decreases expression EXP Clozapine results in decreased expression of PPP2R2A mRNA CTD PMID:15860345 NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions
increases expression
decreases expression
EXP [Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein
Clozapine results in increased expression of PPP3CA mRNA
Clozapine results in decreased expression of PPP3CA mRNA; Clozapine results in decreased expression of PPP3CA protein
CTD PMID:12437575 PMID:16033416 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Ppp4r2 protein phosphatase 4, regulatory subunit 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of PPP4R2 protein CTD PMID:34122009 NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:133,454,555...133,495,486
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit affects expression ISO Clozapine affects the expression of PPP5C mRNA CTD PMID:14647396 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of PRDX1 protein CTD PMID:34122009 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases expression EXP Clozapine results in increased expression of PRKACA mRNA CTD PMID:15860345 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta decreases expression
increases expression
EXP Clozapine results in decreased expression of PRKACB mRNA; Clozapine results in decreased expression of PRKACB protein
Clozapine results in increased expression of PRKACB mRNA
CTD PMID:11907174 PMID:15860345 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha multiple interactions
decreases expression
EXP
ISO
Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2A protein]
[Cuprizone co-treated with Clozapine] results in decreased expression of PRKAR2A protein
Clozapine results in decreased expression of PRKAR2A mRNA; Clozapine results in decreased expression of PRKAR2A protein
CTD PMID:11907174 PMID:34122009 NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628
JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta decreases expression
multiple interactions
EXP Clozapine results in decreased expression of PRKAR2B mRNA; Clozapine results in decreased expression of PRKAR2B protein
Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2B protein]
CTD PMID:11907174 PMID:15860345 NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933
JBrowse link
G Prkcb protein kinase C, beta affects expression
increases expression
EXP Clozapine affects the expression of PRKCB protein
Clozapine results in increased expression of PRKCB mRNA
CTD PMID:15860345 PMID:15967061 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkce protein kinase C, epsilon increases expression EXP Clozapine results in increased expression of PRKCE mRNA CTD PMID:15860345 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prkcz protein kinase C, zeta increases expression EXP Clozapine results in increased expression of PRKCZ mRNA CTD PMID:15860345 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Prl prolactin increases secretion
increases expression
multiple interactions
ISO
EXP
Clozapine results in increased secretion of PRL protein
Clozapine analog results in increased expression of PRL protein
[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein; [Risperidone co-treated with Clozapine] results in increased expression of PRL protein
CTD PMID:11155212 PMID:11997696 PMID:15286066 PMID:18562423 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prmt1 protein arginine methyltransferase 1 decreases expression ISO Clozapine results in decreased expression of PRMT1 protein CTD PMID:34122009 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa increases expression ISO Clozapine results in increased expression of PROC protein CTD PMID:20126316 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Prpf38b pre-mRNA processing factor 38B decreases expression ISO Clozapine results in decreased expression of PRPF38B mRNA CTD PMID:14647396 NCBI chr 2:196,553,224...196,562,271
Ensembl chr 2:196,553,225...196,562,250
JBrowse link
G Prpf6 pre-mRNA processing factor 6 decreases expression
multiple interactions
ISO Clozapine results in decreased expression of PRPF6 protein
[Cuprizone co-treated with Clozapine] results in decreased expression of PRPF6 protein
CTD PMID:34122009 NCBI chr 3:168,706,952...168,771,191
Ensembl chr 3:168,704,299...168,774,991
JBrowse link
G Prrc2a proline-rich coiled-coil 2A decreases expression ISO Clozapine results in decreased expression of PRRC2A mRNA CTD PMID:18797397 NCBI chr20:3,658,391...3,674,143
Ensembl chr20:3,658,695...3,674,130
JBrowse link
G Psmb5 proteasome 20S subunit beta 5 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of PSMB5 protein CTD PMID:34122009 NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
JBrowse link
G Psmb7 proteasome 20S subunit beta 7 decreases expression ISO Clozapine results in decreased expression of PSMB7 protein CTD PMID:34122009 NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937
JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 increases expression ISO Clozapine results in increased expression of PSMC3 protein CTD PMID:34122009 NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358
JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 increases expression ISO Clozapine results in increased expression of PSMC5 protein CTD PMID:34122009 NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135
JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 increases expression ISO Clozapine results in increased expression of PSMD14 protein CTD PMID:34122009 NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076
JBrowse link
G Psmd7 proteasome 26S subunit, non-ATPase 7 increases expression ISO Clozapine results in increased expression of PSMD7 protein CTD PMID:34122009 NCBI chr19:35,494,317...35,501,605
Ensembl chr19:35,494,316...35,501,588
JBrowse link
G Ptcd3 Pentatricopeptide repeat domain 3 increases expression ISO Clozapine results in increased expression of PTCD3 protein CTD PMID:34122009 NCBI chr 4:103,922,440...103,957,445
Ensembl chr 4:103,920,566...103,957,538
JBrowse link
G Ptgds prostaglandin D2 synthase decreases expression
increases expression
ISO Clozapine results in decreased expression of PTGDS mRNA
Clozapine results in increased expression of PTGDS mRNA
CTD PMID:15542763 PMID:17266109 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
JBrowse link
G Ptk2 protein tyrosine kinase 2 increases expression ISO Clozapine results in increased expression of PTK2 protein CTD PMID:34122009 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptma prothymosin alpha increases expression ISO Clozapine results in increased expression of PTMA protein CTD PMID:34122009 NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
JBrowse link
G Ptms parathymosin increases expression ISO Clozapine results in increased expression of PTMS mRNA CTD PMID:14647396 NCBI chr 4:157,722,384...157,726,575
Ensembl chr 4:157,722,386...157,727,009
JBrowse link
G Pvalb parvalbumin multiple interactions EXP Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA] CTD PMID:12589379 NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
JBrowse link
G Pwp2 PWP2, small subunit processome component increases expression ISO Clozapine results in increased expression of PWP2 protein CTD PMID:34122009 NCBI chr20:10,499,332...10,512,965
Ensembl chr20:10,499,363...10,513,640
JBrowse link
G Pycr1 pyrroline-5-carboxylate reductase 1 increases expression ISO Clozapine results in increased expression of PYCR1 protein CTD PMID:34122009 NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549
JBrowse link
G Qdpr quinoid dihydropteridine reductase decreases expression ISO Clozapine results in decreased expression of QDPR protein CTD PMID:34122009 NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854
JBrowse link
G Rab12 RAB12, member RAS oncogene family decreases expression EXP Clozapine results in decreased expression of RAB12 mRNA CTD PMID:12437575 NCBI chr 9:106,480,301...106,506,895
Ensembl chr 9:106,480,301...106,506,910
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of RAC1 protein CTD PMID:34122009 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rack1 receptor for activated C kinase 1 decreases expression ISO Clozapine results in decreased expression of RACK1 protein CTD PMID:34122009 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975
JBrowse link
G Ralyl RALY RNA binding protein-like increases expression ISO Clozapine results in increased expression of RALYL protein CTD PMID:34122009 NCBI chr 2:87,482,747...88,274,329
Ensembl chr 2:87,482,755...88,274,452
JBrowse link
G Ran RAN, member RAS oncogene family decreases expression ISO Clozapine results in decreased expression of RAN protein CTD PMID:34122009 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
JBrowse link
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 increases expression ISO Clozapine results in increased expression of RAP1GDS1 protein CTD PMID:34122009 NCBI chr 2:227,500,366...227,645,243
Ensembl chr 2:227,500,367...227,645,169
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO Clozapine results in decreased expression of RAPGEF4 mRNA CTD PMID:18797397 NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 affects expression EXP Clozapine affects the expression of RASGRF1 mRNA CTD PMID:12437575 NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269
JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor decreases expression ISO Clozapine results in decreased expression of RBBP4 protein CTD PMID:34122009 NCBI chr 5:141,655,863...141,675,157
Ensembl chr 5:141,638,421...141,675,284
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression EXP Clozapine results in decreased expression of RELA protein CTD PMID:16500086 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Reln reelin decreases expression
multiple interactions
decreases methylation
ISO
EXP
Clozapine results in decreased expression of RELN mRNA
Clozapine results in decreased expression of RELN protein
Valproic Acid promotes the reaction [Clozapine results in decreased methylation of RELN promoter]
CTD PMID:17266109 PMID:18757738 PMID:19359144 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Rfc5 replication factor C subunit 5 increases expression ISO Clozapine results in increased expression of RFC5 protein CTD PMID:34122009 NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312
JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression EXP
ISO
Clozapine results in increased expression of RGS4 mRNA CTD PMID:15860345 PMID:17266109 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Rgs7 regulator of G-protein signaling 7 multiple interactions
increases expression
EXP [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]
Clozapine results in increased expression of RGS7 mRNA
CTD PMID:18976543 NCBI chr13:86,979,269...87,408,834
Ensembl chr13:86,979,279...87,408,888
JBrowse link
G Rgs8 regulator of G-protein signaling 8 increases expression EXP Clozapine results in increased expression of RGS8 mRNA CTD PMID:15860345 NCBI chr13:65,804,703...65,848,953
Ensembl chr13:65,804,797...65,846,807
JBrowse link
G Ric8a RIC8 guanine nucleotide exchange factor A decreases expression ISO Clozapine results in decreased expression of RIC8A protein CTD PMID:34122009 NCBI chr 1:195,935,162...195,941,469
Ensembl chr 1:195,935,349...195,941,467
JBrowse link
G Rnf20 ring finger protein 20 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of RNF20 protein CTD PMID:34122009 NCBI chr 5:63,976,063...64,001,754
Ensembl chr 5:63,976,045...64,001,754
JBrowse link
G Rorb RAR-related orphan receptor B decreases expression EXP Clozapine results in decreased expression of RORB mRNA CTD PMID:11564422 NCBI chr 1:216,363,629...216,544,390
Ensembl chr 1:216,363,629...216,544,390
JBrowse link
G Rpa1 replication protein A1 decreases expression ISO Clozapine results in decreased expression of RPA1 protein CTD PMID:34122009 NCBI chr10:60,148,869...60,199,999
Ensembl chr10:60,148,793...60,199,949
JBrowse link
G Rpl11 ribosomal protein L11 increases expression ISO Clozapine results in increased expression of RPL11 protein CTD PMID:34122009 NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599
JBrowse link
G Rpl19 ribosomal protein L19 increases expression ISO Clozapine results in increased expression of RPL19 protein CTD PMID:34122009 NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112
JBrowse link
G Rpl30 ribosomal protein L30 increases expression ISO Clozapine results in increased expression of RPL30 protein CTD PMID:34122009 NCBI chr 7:65,648,470...65,651,363
Ensembl chr 7:65,645,991...65,651,363
Ensembl chr10:65,645,991...65,651,363
JBrowse link
G Rpl5 ribosomal protein L5 increases expression ISO Clozapine results in increased expression of RPL5 protein CTD PMID:34122009 NCBI chr14:1,843,856...1,850,301
Ensembl chr14:1,843,770...1,850,290
JBrowse link
G Rplp0l1 ribosomal protein lateral stalk subunit P0 like 1 decreases expression ISO Clozapine results in decreased expression of RPLP0P6 protein CTD PMID:34122009 NCBI chr 2:191,921,503...191,922,661
Ensembl chr 2:191,921,574...191,922,646
JBrowse link
G Rplp2 ribosomal protein lateral stalk subunit P2 increases expression ISO Clozapine results in increased expression of RPLP2 mRNA CTD PMID:14647396 NCBI chr 1:196,546,086...196,548,636
Ensembl chr 1:196,546,352...196,548,645
JBrowse link
G Rpn2 ribophorin II decreases expression ISO Clozapine results in decreased expression of RPN2 protein CTD PMID:34122009 NCBI chr 3:145,941,787...145,989,271
Ensembl chr 3:145,941,839...145,989,543
JBrowse link
G Rps10 ribosomal protein S10 increases expression ISO Clozapine results in increased expression of RPS10 mRNA CTD PMID:14647396 NCBI chr20:5,694,313...5,698,922
Ensembl chr20:5,694,313...5,699,044
JBrowse link
G Rps11 ribosomal protein S11 decreases expression ISO Clozapine results in decreased expression of RPS11 protein CTD PMID:34122009 NCBI chr 1:95,605,690...95,607,798
Ensembl chr 1:95,605,692...95,607,874
JBrowse link
G Rps3 ribosomal protein S3 decreases expression ISO Clozapine results in decreased expression of RPS3 protein CTD PMID:34122009 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680
JBrowse link
G Rrbp1 ribosome binding protein 1 decreases expression ISO Clozapine results in decreased expression of RRBP1 protein CTD PMID:34122009 NCBI chr 3:131,314,996...131,376,930
Ensembl chr 3:131,314,998...131,376,981
JBrowse link
G Rsf1 remodeling and spacing factor 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of RSF1 protein CTD PMID:34122009 NCBI chr 1:151,892,055...152,015,089
Ensembl chr 1:151,892,434...152,009,051
JBrowse link
G Rspry1 ring finger and SPRY domain containing 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of RSPRY1 protein CTD PMID:34122009 NCBI chr19:10,352,449...10,403,015
Ensembl chr19:10,353,821...10,401,102
JBrowse link
G Rtcb RNA 2',3'-cyclic phosphate and 5'-OH ligase increases expression ISO Clozapine results in increased expression of RTCB protein CTD PMID:34122009 NCBI chr 7:17,907,786...17,927,134
Ensembl chr 7:17,907,705...17,927,132
JBrowse link
G Rtn4 reticulon 4 increases expression ISO Clozapine results in increased expression of RTN4 mRNA CTD PMID:17266109 NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686
JBrowse link
G Rxrg retinoid X receptor gamma decreases expression EXP Clozapine results in decreased expression of RXRG mRNA alternative form CTD PMID:11564422 NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167
JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression ISO Clozapine results in decreased expression of S100A9 mRNA CTD PMID:18797397 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Safb scaffold attachment factor B increases expression ISO Clozapine results in increased expression of SAFB protein CTD PMID:34122009 NCBI chr 9:1,417,449...1,438,408
Ensembl chr 9:1,417,525...1,438,644
JBrowse link
G Sars1 seryl-tRNA synthetase 1 decreases expression ISO Clozapine results in decreased expression of SARS protein CTD PMID:34122009 NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277
JBrowse link
G Satb2 SATB homeobox 2 increases expression ISO Clozapine results in increased expression of SATB2 protein CTD PMID:34122009 NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Clozapine results in increased expression of SC5D mRNA CTD PMID:17052361 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Clozapine results in increased expression of SCD mRNA CTD PMID:16027736 PMID:17052361 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sdcbp syndecan binding protein decreases expression ISO Clozapine results in decreased expression of SDCBP protein CTD PMID:34122009 NCBI chr 5:19,473,499...19,517,188
Ensembl chr 5:19,489,961...19,527,572
JBrowse link
G Sec31a SEC31 homolog A, COPII coat complex component increases expression ISO Clozapine results in increased expression of SEC31A protein CTD PMID:34122009 NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273
JBrowse link
G Sec61b SEC61 translocon subunit beta increases expression ISO Clozapine results in increased expression of SEC61B protein CTD PMID:34122009 NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804
JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator increases expression ISO Clozapine results in increased expression of SEC63 protein CTD PMID:34122009 NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055
JBrowse link
G Septin14 septin 14 decreases expression ISO Clozapine results in decreased expression of SEPTIN14 protein CTD PMID:34122009 NCBI chr12:26,975,283...27,005,588
Ensembl chr12:26,975,344...26,998,299
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression ISO Clozapine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:123,323,632...123,331,166
Ensembl chr 6:123,323,629...123,332,433
JBrowse link
G Serpine2 serpin family E member 2 increases expression EXP Clozapine results in increased expression of SERPINE2 mRNA; Clozapine results in increased expression of SERPINE2 protein CTD PMID:15354176 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
JBrowse link
G SET SET nuclear proto-oncogene multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of SET protein CTD PMID:34122009 NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567
JBrowse link
G Setx senataxin increases expression ISO Clozapine results in increased expression of SETX protein CTD PMID:34122009 NCBI chr 3:12,428,091...12,480,801
Ensembl chr 3:12,427,635...12,480,803
JBrowse link
G Sf3b3 splicing factor 3b, subunit 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SF3B3 protein CTD PMID:34122009 NCBI chr19:38,782,749...38,820,271
Ensembl chr19:38,783,040...38,820,245
JBrowse link
G Sfpq splicing factor proline and glutamine rich decreases expression ISO Clozapine results in decreased expression of SFPQ protein CTD PMID:34122009 NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472
JBrowse link
G Sfxn1 sideroflexin 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SFXN1 protein CTD PMID:34122009 NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO
EXP
Clozapine results in increased expression of SGK1 mRNA CTD PMID:17266109 PMID:18208916 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 increases expression ISO Clozapine results in increased expression of SH3GL1 protein CTD PMID:34122009 NCBI chr 9:842,285...869,753
Ensembl chr 9:842,288...869,716
JBrowse link
G Sh3kbp1 SH3 domain-containing kinase-binding protein 1 increases expression ISO Clozapine results in increased expression of SH3KBP1 protein CTD PMID:34122009 NCBI chr  X:34,877,862...35,223,013
Ensembl chr  X:34,877,866...35,222,747
JBrowse link
G Sh3pxd2b SH3 and PX domains 2B multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SH3PXD2B protein CTD PMID:34122009 NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170
JBrowse link
G Sim2 SIM bHLH transcription factor 2 decreases expression ISO Clozapine results in decreased expression of SIM2 protein CTD PMID:34122009 NCBI chr11:33,414,218...33,453,663
Ensembl chr11:33,414,218...33,453,663
JBrowse link
G Skp1 S-phase kinase-associated protein 1 decreases expression ISO Clozapine results in decreased expression of SKP1 protein CTD PMID:34122009 NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388
JBrowse link
G Slc17a6 solute carrier family 17 member 6 increases expression ISO Clozapine results in increased expression of SLC17A6 mRNA; Clozapine results in increased expression of SLC17A6 protein CTD PMID:17266109 PMID:18155072 NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542
JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression ISO Clozapine results in increased expression of SLC17A7 mRNA; Clozapine results in increased expression of SLC17A7 protein CTD PMID:16111724 NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
JBrowse link
G Slc18a2 solute carrier family 18 member A2 increases expression EXP Clozapine results in increased expression of SLC18A2 mRNA; Clozapine results in increased expression of SLC18A2 protein CTD PMID:12007678 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases expression EXP Clozapine results in decreased expression of SLC1A1 mRNA CTD PMID:12873733 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Slc1a2 solute carrier family 1 member 2 decreases activity
decreases expression
EXP Clozapine results in decreased activity of SLC1A2 protein
Clozapine results in decreased expression of SLC1A2 mRNA; Clozapine results in decreased expression of SLC1A2 protein
CTD PMID:11443521 PMID:12873733 NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Clozapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:30465787 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc25a13 solute carrier family 25 member 13 increases expression ISO Clozapine results in increased expression of SLC25A13 protein CTD PMID:34122009 NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902
JBrowse link
G Slc25a24 solute carrier family 25 member 24 increases expression ISO Clozapine results in increased expression of SLC25A24 protein CTD PMID:34122009 NCBI chr 2:196,761,076...196,799,236
Ensembl chr 2:196,761,274...196,799,231
JBrowse link
G Slc25a6 solute carrier family 25 member 6 increases expression ISO Clozapine results in increased expression of SLC25A6 protein CTD PMID:34122009 NCBI chr18:68,571,229...68,572,474
Ensembl chr18:68,571,300...68,572,199
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Clozapine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc39a7 solute carrier family 39 member 7 increases expression ISO Clozapine results in increased expression of SLC39A7 mRNA CTD PMID:14647396 NCBI chr20:4,823,166...4,826,538
Ensembl chr20:4,822,012...4,826,537
JBrowse link
G Slc6a2 solute carrier family 6 member 2 decreases expression EXP Clozapine results in decreased expression of SLC6A2 mRNA CTD PMID:18923069 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc6a3 solute carrier family 6 member 3 affects response to substance ISO SLC6A3 5' UTR affects the susceptibility to Clozapine CTD PMID:20580759 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions
increases expression
affects response to substance
ISO
EXP
[SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine
Clozapine results in increased expression of SLC6A4
SLC6A4 protein affects the susceptibility to Clozapine
CTD PMID:12007678 PMID:20452607 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 decreases expression ISO Clozapine results in decreased expression of SMARCB1 protein CTD PMID:34122009 NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620
JBrowse link
G Smarcc2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SMARCC2 protein CTD PMID:34122009 NCBI chr 7:881,844...910,090
Ensembl chr 7:881,421...909,978
JBrowse link
G Smc2 structural maintenance of chromosomes 2 decreases expression ISO Clozapine results in decreased expression of SMC2 protein CTD PMID:34122009 NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242
JBrowse link
G Smc3 structural maintenance of chromosomes 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SMC3 protein CTD PMID:34122009 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
JBrowse link
G Snap25 synaptosome associated protein 25 increases expression
affects response to substance
EXP
ISO
Clozapine results in increased expression of SNAP25 mRNA
SNAP25 gene SNP affects the susceptibility to Clozapine
CTD PMID:15823421 PMID:15860345 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
JBrowse link
G Snrnp200 small nuclear ribonucleoprotein U5 subunit 200 increases expression ISO Clozapine results in increased expression of SNRNP200 protein CTD PMID:34122009 NCBI chr 3:114,428,854...114,458,194
Ensembl chr 3:114,428,854...114,458,182
JBrowse link
G Snrpb small nuclear ribonucleoprotein polypeptides B and B1 increases expression ISO Clozapine results in increased expression of SNRPB protein CTD PMID:34122009 NCBI chr 3:117,369,816...117,379,344
Ensembl chr 3:117,370,100...117,379,339
JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide increases expression ISO Clozapine results in increased expression of SNRPD2 mRNA CTD PMID:14647396 NCBI chr 1:78,798,377...78,801,227
Ensembl chr 1:78,798,377...78,803,351
JBrowse link
G Snx1 sorting nexin 1 decreases expression ISO Clozapine results in decreased expression of SNX1 protein CTD PMID:34122009 NCBI chr 8:66,630,086...66,670,418
Ensembl chr 8:66,630,086...66,670,360
JBrowse link
G Snx6 sorting nexin 6 increases expression ISO Clozapine results in increased expression of SNX6 protein CTD PMID:34122009 NCBI chr 6:72,230,950...72,274,157
Ensembl chr 6:72,229,870...72,315,911
JBrowse link
G Sod1 superoxide dismutase 1 increases expression
decreases expression
multiple interactions
EXP
ISO
Clozapine results in increased expression of SOD1 mRNA
Clozapine results in decreased expression of SOD1 protein
Clozapine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; Clozapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]
CTD PMID:12111809 PMID:12752374 PMID:16564057 PMID:34122009 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP Clozapine results in decreased expression of SOD2 mRNA CTD PMID:15860345 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sod3 superoxide dismutase 3 increases expression EXP Clozapine results in increased expression of SOD3 mRNA CTD PMID:15860345 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression
increases expression
EXP Clozapine results in decreased expression of SOS1 mRNA
Clozapine results in increased expression of SOS1 mRNA
CTD PMID:12437575 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO Clozapine results in decreased expression of SPP1 mRNA CTD PMID:17346280 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 decreases expression ISO Clozapine results in decreased expression of SPTLC1 protein CTD PMID:34122009 NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions
ISO Clozapine results in increased expression of SREBF1 mRNA
Clozapine results in increased expression of SREBF1 mRNA; Clozapine results in increased expression of SREBF1 protein
Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]
CTD PMID:17052361 PMID:19682446 PMID:20564506 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions
increases expression
ISO Clozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]; Clozapine results in increased cleavage of and results in increased activity of SREBF2 protein
Clozapine results in increased expression of SREBF2 mRNA
CTD PMID:17052361 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 decreases expression ISO Clozapine results in decreased expression of SRRM2 protein CTD PMID:34122009 NCBI chr10:12,815,471...12,848,750
Ensembl chr10:12,815,471...12,848,751
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of SRSF2 protein CTD PMID:34122009 NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 multiple interactions
increases expression
ISO [Cuprizone co-treated with Clozapine] results in increased expression of SRSF5 protein
Clozapine results in increased expression of SRSF5 protein
CTD PMID:34122009 NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 decreases expression ISO Clozapine results in decreased expression of SRSF7 protein CTD PMID:34122009 NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965
JBrowse link
G Ssr3 signal sequence receptor subunit 3 decreases expression ISO Clozapine results in decreased expression of SSR3 protein CTD PMID:34122009 NCBI chr 2:149,605,005...149,625,069
Ensembl chr 2:149,605,005...149,625,132
JBrowse link
G Sst somatostatin multiple interactions EXP Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein] CTD PMID:16567023 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
JBrowse link
G Stim1 stromal interaction molecule 1 decreases expression ISO Clozapine results in decreased expression of STIM1 protein CTD PMID:34122009 NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Clozapine results in decreased expression of STIP1 protein CTD PMID:34122009 NCBI chr 1:204,209,434...204,228,452
Ensembl chr 1:204,178,932...204,228,476
JBrowse link
G Strap serine/threonine kinase receptor associated protein decreases expression ISO Clozapine results in decreased expression of STRAP protein CTD PMID:34122009 NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828
JBrowse link
G Strn4 striatin 4 increases expression ISO Clozapine results in increased expression of STRN4 mRNA CTD PMID:14647396 NCBI chr 1:77,482,267...77,511,862
Ensembl chr 1:77,482,094...77,511,858
JBrowse link
G Stx1a syntaxin 1A increases expression EXP Clozapine results in increased expression of STX1A mRNA CTD PMID:15860345 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
JBrowse link
G Stx1b syntaxin 1B increases expression EXP Clozapine results in increased expression of STX1B mRNA CTD PMID:15860345 NCBI chr 1:182,415,544...182,434,385
Ensembl chr 1:182,415,546...182,441,280
JBrowse link
G Stx4 syntaxin 4 increases expression EXP Clozapine results in increased expression of STX4 mRNA CTD PMID:15860345 NCBI chr 1:182,451,108...182,459,701
Ensembl chr 1:182,451,117...182,459,979
JBrowse link
G Stx8 syntaxin 8 affects expression EXP Clozapine affects the expression of STX8 mRNA CTD PMID:15860345 NCBI chr10:52,655,643...52,900,048
Ensembl chr10:52,654,990...52,894,993
JBrowse link
G Stxbp1 syntaxin binding protein 1 affects expression EXP Clozapine affects the expression of STXBP1 mRNA CTD PMID:12437575 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SUCLA2 protein CTD PMID:34122009 NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138
JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha decreases expression ISO Clozapine results in decreased expression of SUCLG1 protein CTD PMID:34122009 NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600
JBrowse link
G Supt3h SPT3 homolog, SAGA and STAGA complex component increases expression EXP Clozapine results in increased expression of SUPT3H mRNA CTD PMID:16715494 NCBI chr 9:15,878,296...16,206,768
Ensembl chr 9:15,868,287...16,206,706
JBrowse link
G Syn2 synapsin II decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of SYN2 mRNA
Clozapine results in increased expression of SYN2 mRNA
CTD PMID:15860345 PMID:17266109 NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192
JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein decreases expression ISO Clozapine results in decreased expression of SYNCRIP protein CTD PMID:34122009 NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515
JBrowse link
G Syt11 synaptotagmin 11 increases expression EXP Clozapine results in increased expression of SYT11 mRNA CTD PMID:15860345 NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964
JBrowse link
G Syt2 synaptotagmin 2 increases expression ISO Clozapine results in increased expression of SYT2 mRNA CTD PMID:17266109 NCBI chr13:46,088,046...46,197,976
Ensembl chr13:46,185,282...46,193,859
JBrowse link
G Syt4 synaptotagmin 4 increases expression EXP Clozapine results in increased expression of SYT4 mRNA CTD PMID:15860345 NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332
JBrowse link
G Syt5 synaptotagmin 5 decreases expression EXP Clozapine results in decreased expression of SYT5 mRNA CTD PMID:12437575 NCBI chr 1:69,277,351...69,285,071
Ensembl chr 1:69,277,351...69,285,067
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression ISO
EXP
Clozapine results in decreased expression of TAC1 mRNA CTD PMID:10974607 PMID:17266109 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tagln transgelin decreases expression ISO Clozapine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tagln2 transgelin 2 decreases expression ISO Clozapine results in decreased expression of TAGLN2 protein CTD PMID:34122009 NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972
JBrowse link
G Taok2 TAO kinase 2 increases expression ISO Clozapine results in increased expression of TAOK2 protein CTD PMID:34122009 NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613
JBrowse link
G Tatdn1 TatD DNase domain containing 1 increases expression ISO Clozapine results in increased expression of TATDN1 mRNA CTD PMID:14647396 NCBI chr 7:90,451,025...90,481,000
Ensembl chr 7:90,441,079...90,481,133
JBrowse link
G Tbc1d8b TBC1 domain family member 8B increases expression ISO Clozapine results in increased expression of TBC1D8B protein CTD PMID:34122009 NCBI chr  X:103,319,181...103,407,137
Ensembl chr  X:103,319,340...103,407,133
JBrowse link
G Tbcb tubulin folding cofactor B multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TBCB protein CTD PMID:34122009 NCBI chr 1:85,477,639...85,483,488
Ensembl chr 1:85,477,640...85,483,488
JBrowse link
G Tbl3 transducin (beta)-like 3 increases expression ISO Clozapine results in increased expression of TBL3 protein CTD PMID:34122009 NCBI chr10:13,726,127...13,731,340
Ensembl chr10:13,726,129...13,731,372
JBrowse link
G Tcaf1 TRPM8 channel-associated factor 1 decreases expression ISO Clozapine results in decreased expression of TCAF1 protein CTD PMID:34122009 NCBI chr 4:71,589,674...71,639,309
Ensembl chr 4:71,591,200...71,613,309
JBrowse link
G Tes testin LIM domain protein decreases expression ISO Clozapine results in decreased expression of TES protein CTD PMID:34122009 NCBI chr 4:45,365,304...45,403,829
Ensembl chr 4:45,365,285...45,403,829
JBrowse link
G Tgoln2 trans-golgi network protein 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TGOLN2 protein CTD PMID:34122009 NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164
JBrowse link
G Th tyrosine hydroxylase decreases activity
multiple interactions
increases expression
decreases expression
increases activity
EXP
ISO
Clozapine results in decreased activity of TH protein
Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]
Clozapine results in increased expression of TH protein
Clozapine results in decreased expression of TH mRNA; Clozapine results in decreased expression of TH protein
Clozapine results in increased activity of TH protein
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]; [Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine
CTD PMID:12645084 PMID:15983997 PMID:16402076 PMID:16415089 PMID:17028028 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thra thyroid hormone receptor alpha decreases expression
increases expression
EXP Clozapine results in decreased expression of THRA mRNA alternative form
Clozapine results in increased expression of THRA mRNA alternative form
CTD PMID:11564422 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrap3 thyroid hormone receptor associated protein 3 decreases expression ISO Clozapine results in decreased expression of THRAP3 protein CTD PMID:34122009 NCBI chr 5:138,445,284...138,487,544
Ensembl chr 5:138,445,295...138,487,477
JBrowse link
G Thrb thyroid hormone receptor beta decreases expression EXP Clozapine results in decreased expression of THRB mRNA alternative form CTD PMID:11564422 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Tln2 talin 2 decreases expression ISO Clozapine results in decreased expression of TLN2 protein CTD PMID:34122009 NCBI chr 8:67,830,920...68,252,223
Ensembl chr 8:67,834,326...68,252,219
JBrowse link
G Tm9sf2 transmembrane 9 superfamily member 2 decreases expression ISO Clozapine results in decreased expression of TM9SF2 protein CTD PMID:34122009 NCBI chr15:99,201,556...99,254,054
Ensembl chr15:99,201,489...99,254,049
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 decreases expression ISO Clozapine results in decreased expression of TMED10 protein CTD PMID:34122009 NCBI chr 6:104,991,843...105,026,705
Ensembl chr 6:104,991,838...105,026,753
JBrowse link
G Tmem109 transmembrane protein 109 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of TMEM109 protein CTD PMID:34122009 NCBI chr 1:207,519,628...207,530,245
Ensembl chr 1:207,519,624...207,530,215
JBrowse link
G Tmpo thymopoietin decreases expression ISO Clozapine results in decreased expression of TMPO protein CTD PMID:34122009 NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727
JBrowse link
G Tnf tumor necrosis factor affects response to substance
increases secretion
multiple interactions
increases expression
ISO
EXP
TNF protein affects the susceptibility to Clozapine
Clozapine results in increased secretion of TNF protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of TNF protein]
Clozapine results in increased expression of TNF protein
CTD PMID:20521320 PMID:24709159 PMID:34935985 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf15 TNF superfamily member 15 decreases expression ISO Clozapine results in decreased expression of TNFSF15 mRNA CTD PMID:17346280 NCBI chr 5:77,140,099...77,156,142
Ensembl chr 5:77,139,878...77,156,228
JBrowse link
G Tnik TRAF2 and NCK interacting kinase decreases expression ISO Clozapine results in decreased expression of TNIK mRNA CTD PMID:14647396 NCBI chr 2:111,184,352...111,587,993
Ensembl chr 2:111,184,387...111,580,750
JBrowse link
G Top1mt DNA topoisomerase I mitochondrial increases expression ISO Clozapine results in increased expression of TOP1MT protein CTD PMID:34122009 NCBI chr 7:107,338,092...107,368,125
Ensembl chr 7:107,342,527...107,366,049
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Clozapine results in increased expression of TP53 mRNA
CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA]
CTD PMID:16160616 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP Clozapine results in increased expression of TPI1 mRNA CTD PMID:15860345 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
JBrowse link
G Tpm2 tropomyosin 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TPM2 protein CTD PMID:34122009 NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992
JBrowse link
G Tpm3 tropomyosin 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TPM3 protein CTD PMID:34122009 NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013
JBrowse link
G Tpm4 tropomyosin 4 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TPM4 protein CTD PMID:34122009 NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984
JBrowse link
G Tpr translocated promoter region, nuclear basket protein decreases expression ISO Clozapine results in decreased expression of TPR protein CTD PMID:34122009 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
JBrowse link
G Tra2b transformer 2 beta homolog decreases expression ISO Clozapine results in decreased expression of TRA2B protein CTD PMID:34122009 NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249
JBrowse link
G Trim2 tripartite motif-containing 2 decreases expression ISO Clozapine results in decreased expression of TRIM2 mRNA CTD PMID:14647396 NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927
JBrowse link
G Trim28 tripartite motif-containing 28 decreases expression ISO Clozapine results in decreased expression of TRIM28 protein CTD PMID:34122009 NCBI chr 1:73,652,441...73,659,388
Ensembl chr 1:73,652,709...73,659,380
JBrowse link
G Tspan3 tetraspanin 3 decreases expression ISO Clozapine results in decreased expression of TSPAN3 protein CTD PMID:34122009 NCBI chr 8:56,546,067...56,569,815
Ensembl chr 8:56,546,069...56,569,880
JBrowse link
G Ttbk1 tau tubulin kinase 1 increases expression ISO Clozapine results in increased expression of TTBK1 protein CTD PMID:34122009 NCBI chr 9:14,493,166...14,538,372
Ensembl chr 9:14,493,389...14,535,774
JBrowse link
G Ttr transthyretin decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of TTR mRNA
Clozapine results in increased expression of TTR mRNA; Clozapine results in increased expression of TTR protein
CTD PMID:15927202 PMID:17266109 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
G Ttyh2 tweety family member 2 increases expression ISO Clozapine results in increased expression of TTYH2 protein CTD PMID:34122009 NCBI chr10:99,708,998...99,753,451
Ensembl chr10:99,709,007...99,753,444
JBrowse link
G Tubal3 tubulin, alpha-like 3 increases expression ISO Clozapine results in increased expression of TUBAL3 protein CTD PMID:34122009 NCBI chr17:66,323,733...66,332,423
Ensembl chr17:66,323,733...66,335,355
JBrowse link
G Tubb4b tubulin, beta 4B class IVb multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TUBB4B protein CTD PMID:34122009 NCBI chr 3:8,037,844...8,040,294
Ensembl chr 3:8,037,799...8,040,296
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression ISO Clozapine results in increased expression of TUBB protein CTD PMID:34122009 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Tubb6 tubulin, beta 6 class V decreases expression ISO Clozapine results in decreased expression of TUBB6 protein CTD PMID:34122009 NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418
JBrowse link
G Uap1l1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 increases expression ISO Clozapine results in increased expression of UAP1L1 protein CTD PMID:34122009 NCBI chr 3:8,172,335...8,180,505
Ensembl chr 3:8,173,216...8,180,443
JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of UBA2 protein CTD PMID:34122009 NCBI chr 1:86,775,239...86,802,685
Ensembl chr 1:86,775,244...86,802,682
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 increases expression ISO Clozapine results in increased expression of UBA52 mRNA CTD PMID:14647396 NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807
JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 affects expression ISO Clozapine affects the expression of UBE2R2 mRNA CTD PMID:14647396 NCBI chr 5:56,286,604...56,345,160
Ensembl chr 5:56,286,725...56,345,513