Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:oleanolic acid
go back to main search page
Accession:CHEBI:37659 term browser browse the term
Definition:A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.
Synonyms:related_synonym: 3beta-Hydroxyolean-12-en-28-oic acid;   Astrantiagenin C;   Caryophyllin;   Formula=C30H48O3;   Giganteumgenin C;   InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1;   InChIKey=MIJYXULNPSFWEK-GTOFXWBISA-N;   Oleanic acid;   SMILES=[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O;   Virgaureagenin B
 xref: CAS:508-02-1;   KEGG:C17148
 xref_mesh: MESH:D009828
 xref: PMID:15541359;   PMID:24393202;   Wikipedia:Oleanolic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:82828


show annotations for term's descendants       view all columns           Sort by:
 
oleanolic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB11 ATP binding cassette subfamily B member 11 JBrowse link 2 168,915,468 169,031,396 RGD:6480464
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) JBrowse link 4 88,090,264 88,231,626 RGD:6480464
G ACTA2 actin alpha 2, smooth muscle JBrowse link 10 88,935,074 88,991,397 RGD:6480464
G ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide JBrowse link 4 99,336,497 99,352,746 RGD:6480464
G AGER advanced glycosylation end-product specific receptor JBrowse link 6 32,180,968 32,184,380 RGD:6480464
G AKR1B10 aldo-keto reductase family 1 member B10 JBrowse link 7 134,527,567 134,541,412 RGD:6480464
G AKT1 AKT serine/threonine kinase 1 JBrowse link 14 104,769,349 104,795,748 RGD:6480464
G ATG5 autophagy related 5 JBrowse link 6 106,184,476 106,325,820 RGD:6480464
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 48,954,825 48,961,798 RGD:6480464
G BCL2 BCL2 apoptosis regulator JBrowse link 18 63,123,346 63,320,280 RGD:6480464
G BCL2L1 BCL2 like 1 JBrowse link 20 31,664,452 31,723,963 RGD:6480464
G BECN1 beclin 1 JBrowse link 17 42,810,132 42,824,316 RGD:6480464
G BIRC5 baculoviral IAP repeat containing 5 JBrowse link 17 78,214,253 78,225,635 RGD:6480464
G CASP3 caspase 3 JBrowse link 4 184,627,696 184,649,475 RGD:6480464
G CASP8 caspase 8 JBrowse link 2 201,233,443 201,287,711 RGD:6480464
G CASP9 caspase 9 JBrowse link 1 15,491,401 15,524,912 RGD:6480464
G CAT catalase JBrowse link 11 34,438,934 34,472,060 RGD:6480464
G CCND1 cyclin D1 JBrowse link 11 69,641,156 69,654,474 RGD:6480464
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 36,676,463 36,687,332 RGD:6480464
G COL1A1 collagen type I alpha 1 chain JBrowse link 17 50,184,096 50,201,649 RGD:6480464
G CXCL1 C-X-C motif chemokine ligand 1 JBrowse link 4 73,869,393 73,871,308 RGD:6480464
G CXCL2 C-X-C motif chemokine ligand 2 JBrowse link 4 74,097,040 74,099,195 RGD:6480464
G CXCL6 C-X-C motif chemokine ligand 6 JBrowse link 4 73,836,678 73,838,760 RGD:6480464
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 JBrowse link 15 74,748,845 74,756,607 RGD:6480464
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 JBrowse link 2 218,781,733 218,815,293 RGD:6480464
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 JBrowse link 19 40,991,282 41,018,398 RGD:6480464
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 JBrowse link 10 133,527,363 133,539,123 RGD:6480464
G CYP2F1 cytochrome P450 family 2 subfamily F member 1 JBrowse link 19 41,114,292 41,128,381 RGD:6480464
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 JBrowse link 7 99,756,967 99,784,184 RGD:6480464
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 JBrowse link 8 58,490,178 58,500,163 RGD:6480464
G CYP7B1 cytochrome P450 family 7 subfamily B member 1 JBrowse link 8 64,586,575 64,798,737 RGD:6480464
G CYP8B1 cytochrome P450 family 8 subfamily B member 1 JBrowse link 3 42,872,192 42,875,879 RGD:6480464
G DDIT3 DNA damage inducible transcript 3 JBrowse link 12 57,516,588 57,520,517 RGD:6480464
G GADD45A growth arrest and DNA damage inducible alpha JBrowse link 1 67,685,201 67,688,334 RGD:6480464
G GCLC glutamate-cysteine ligase catalytic subunit JBrowse link 6 53,497,341 53,545,101 RGD:6480464
G GCLM glutamate-cysteine ligase modifier subunit JBrowse link 1 93,885,199 93,910,370 RGD:6480464
G GHRL ghrelin and obestatin prepropeptide JBrowse link 3 10,285,666 10,292,947 RGD:6480464
G GNAS GNAS complex locus JBrowse link 20 58,839,681 58,911,196 RGD:6480464
G GPBAR1 G protein-coupled bile acid receptor 1 JBrowse link 2 218,259,496 218,263,861 RGD:6480464
G GPT glutamic--pyruvic transaminase JBrowse link 8 144,503,068 144,507,172 RGD:6480464
G GPX1 glutathione peroxidase 1 JBrowse link 3 49,357,171 49,358,600 RGD:6480464
G GSR glutathione-disulfide reductase JBrowse link 8 30,678,061 30,727,999 RGD:6480464
G HDAC1 histone deacetylase 1 JBrowse link 1 32,292,083 32,333,628 RGD:6480464
G HMGB1 high mobility group box 1 JBrowse link 13 30,456,704 30,617,597 RGD:6480464
G HMOX1 heme oxygenase 1 JBrowse link 22 35,381,096 35,394,207 RGD:6480464
G HSPA1B heat shock protein family A (Hsp70) member 1B JBrowse link 6 31,827,738 31,830,254 RGD:6480464
G ICAM1 intercellular adhesion molecule 1 JBrowse link 19 10,271,120 10,286,615 RGD:6480464
G IL22 interleukin 22 JBrowse link 12 68,248,242 68,253,604 RGD:6480464
G INS insulin JBrowse link 11 2,159,779 2,161,209 RGD:6480464
G INSR insulin receptor JBrowse link 19 7,112,257 7,294,414 RGD:6480464
G IRS1 insulin receptor substrate 1 JBrowse link 2 226,731,317 226,798,790 RGD:6480464
G LEP leptin JBrowse link 7 128,241,201 128,257,629 RGD:6480464
G MAP1LC3B microtubule associated protein 1 light chain 3 beta JBrowse link 16 87,392,336 87,404,774 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 22 21,759,657 21,867,680 RGD:6480464
G MAPK14 mitogen-activated protein kinase 14 JBrowse link 6 36,027,677 36,122,964 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,114,105 30,123,309 RGD:6480464
G MAPK8 mitogen-activated protein kinase 8 JBrowse link 10 48,306,639 48,439,360 RGD:6480464
G MET MET proto-oncogene, receptor tyrosine kinase JBrowse link 7 116,672,196 116,798,386 RGD:6480464
G MMP2 matrix metallopeptidase 2 JBrowse link 16 55,478,830 55,506,691 RGD:6480464
G MT1A metallothionein 1A JBrowse link 16 56,638,666 56,640,087 RGD:6480464
G MT1X metallothionein 1X JBrowse link 16 56,682,470 56,684,196 RGD:6480464
G MT2A metallothionein 2A JBrowse link 16 56,608,584 56,609,497 RGD:6480464
G MTOR mechanistic target of rapamycin kinase JBrowse link 1 11,106,535 11,273,497 RGD:6480464
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 8 127,735,434 127,742,951 RGD:6480464
G NFE2L2 nuclear factor, erythroid 2 like 2 JBrowse link 2 177,230,303 177,265,131 RGD:6480464
G NFKB1 nuclear factor kappa B subunit 1 JBrowse link 4 102,501,266 102,617,302 RGD:6480464
G NFKBIA NFKB inhibitor alpha JBrowse link 14 35,401,513 35,404,749 RGD:6480464
G NQO1 NAD(P)H quinone dehydrogenase 1 JBrowse link 16 69,709,401 69,726,560 RGD:6480464
G NR1H4 nuclear receptor subfamily 1 group H member 4 JBrowse link 12 100,473,866 100,564,414 RGD:6480464
G NR1I3 nuclear receptor subfamily 1 group I member 3 JBrowse link 1 161,229,666 161,238,623 RGD:6480464
G ORM1 orosomucoid 1 JBrowse link 9 114,323,098 114,326,479 RGD:6480464
G PARP1 poly(ADP-ribose) polymerase 1 JBrowse link 1 226,360,691 226,408,093 RGD:6480464
G PCNA proliferating cell nuclear antigen JBrowse link 20 5,114,953 5,126,622 RGD:6480464
G PIK3C2G phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma JBrowse link 12 18,242,946 18,716,861 RGD:6480464
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 3 179,148,114 179,240,093 RGD:6480464
G PPARA peroxisome proliferator activated receptor alpha JBrowse link 22 46,150,526 46,243,756 RGD:6480464
G PRDX1 peroxiredoxin 1 JBrowse link 1 45,511,035 45,522,890 RGD:6480464
G PTEN phosphatase and tensin homolog JBrowse link 10 87,863,625 87,971,930 RGD:6480464
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 186,671,791 186,680,423 RGD:6480464
G RELA RELA proto-oncogene, NF-kB subunit JBrowse link 11 65,653,596 65,662,972 RGD:6480464
G SELE selectin E JBrowse link 1 169,722,640 169,734,079 RGD:6480464
G SLC10A1 solute carrier family 10 member 1 JBrowse link 14 69,775,416 69,797,241 RGD:6480464
G SLC51A solute carrier family 51 subunit alpha JBrowse link 3 196,216,534 196,233,427 RGD:6480464
G SLC51B solute carrier family 51 subunit beta JBrowse link 15 65,045,387 65,053,397 RGD:6480464
G SLCO1A2 solute carrier organic anion transporter family member 1A2 JBrowse link 12 21,264,600 21,403,663 RGD:6480464
G SLCO1B3 solute carrier organic anion transporter family member 1B3 JBrowse link 12 20,810,705 20,916,911 RGD:6480464
G SOD1 superoxide dismutase 1 JBrowse link 21 31,659,693 31,668,931 RGD:6480464
G SREBF1 sterol regulatory element binding transcription factor 1 JBrowse link 17 17,811,334 17,837,017 RGD:6480464
G STAT3 signal transducer and activator of transcription 3 JBrowse link 17 42,313,324 42,388,502 RGD:6480464
G TIMP1 TIMP metallopeptidase inhibitor 1 JBrowse link X 47,582,408 47,586,789 RGD:6480464
G TNF tumor necrosis factor JBrowse link 6 31,575,565 31,578,336 RGD:6480464
G TNFRSF1B TNF receptor superfamily member 1B JBrowse link 1 12,166,948 12,209,222 RGD:6480464
G TOP1 DNA topoisomerase I JBrowse link 20 41,028,822 41,124,487 RGD:6480464
G TOP2A DNA topoisomerase II alpha JBrowse link 17 40,388,525 40,417,902 RGD:6480464
G TRPV1 transient receptor potential cation channel subfamily V member 1 JBrowse link 17 3,565,446 3,609,411 RGD:6480464
G VCAM1 vascular cell adhesion molecule 1 JBrowse link 1 100,719,640 100,739,045 RGD:6480464
kalopanaxsaponin A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AHR aryl hydrocarbon receptor JBrowse link 7 17,298,652 17,346,147 RGD:6480464
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 JBrowse link 15 74,719,542 74,725,528 RGD:6480464
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 JBrowse link 15 74,748,845 74,756,607 RGD:6480464
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 JBrowse link 19 40,991,282 41,018,398 RGD:6480464
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 JBrowse link 10 133,527,363 133,539,123 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23949
    role 23837
      biological role 23800
        biochemical role 23132
          metabolite 23028
            eukaryotic metabolite 22684
              plant metabolite 19624
                oleanolic acid 98
                  3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 0
                  4-epihederagenin 0
                  acutoside A 0
                  gypsogenin + 0
                  hederagenin + 5
                  oleanolic acid 3-O-[O-beta-D-glucopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->3)-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside] 0
                  oleanolic acid 3-O-beta-D-glucosiduronic acid 0
                  protobassic acid + 0
                  spathodic acid 0
                  spinosic acid A 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 23949
    subatomic particle 23900
      composite particle 23900
        hadron 23900
          baryon 23900
            nucleon 23900
              atomic nucleus 23900
                atom 23900
                  main group element atom 23720
                    p-block element atom 23720
                      carbon group element atom 23436
                        carbon atom 23391
                          organic molecular entity 23391
                            organic group 22055
                              organic divalent group 22029
                                organodiyl group 22029
                                  carbonyl group 22004
                                    carbonyl compound 22004
                                      carboxylic acid 21056
                                        hydroxy carboxylic acid 4251
                                          hydroxy monocarboxylic acid 4251
                                            oleanolic acid 98
                                              3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 0
                                              4-epihederagenin 0
                                              acutoside A 0
                                              gypsogenin + 0
                                              hederagenin + 5
                                              oleanolic acid 3-O-[O-beta-D-glucopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->3)-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside] 0
                                              oleanolic acid 3-O-beta-D-glucosiduronic acid 0
                                              protobassic acid + 0
                                              spathodic acid 0
                                              spinosic acid A 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.