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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oleanolic acid
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Accession:CHEBI:37659 term browser browse the term
Definition:A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.
Synonyms:related_synonym: 3beta-Hydroxyolean-12-en-28-oic acid;   Astrantiagenin C;   Caryophyllin;   Formula=C30H48O3;   Giganteumgenin C;   InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1;   InChIKey=MIJYXULNPSFWEK-GTOFXWBISA-N;   Oleanic acid;   SMILES=[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O;   Virgaureagenin B
 xref: CAS:508-02-1;   KEGG:C17148
 xref_mesh: MESH:D009828
 xref: PMID:15541359;   PMID:24393202;   Wikipedia:Oleanolic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:82828



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oleanolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO Oleanolic Acid results in decreased expression of ABCB11 mRNA; Oleanolic Acid results in decreased expression of ABCB11 protein CTD PMID:23948738 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Oleanolic Acid results in increased expression of ABCG2 mRNA CTD PMID:23948738 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO
Oleanolic Acid analog inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA] CTD PMID:17922224 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) multiple interactions EXP Oleanolic Acid inhibits the reaction [Ethanol results in increased expression of and results in increased activity of ADH1 protein] CTD PMID:25111957 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of AGER protein] CTD PMID:22386814 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased expression of MMP2 mRNA]; Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased secretion of MMP2 protein]; Oleanolic Acid inhibits the reaction [AKR1B10 protein results in decreased susceptibility to Doxorubicin]; Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-hydroxy-2-nonenal]; Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-oxo-2-nonenal] CTD PMID:25686905 PMID:27417252 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
[Fructose co-treated with Oleanolic Acid] results in increased expression of AKT1 mRNA
Oleanolic Acid analog results in increased phosphorylation of AKT1 protein
CTD PMID:24704288 PMID:26612655 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions
ISO Oleanolic Acid analog results in increased expression of ATG5 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of ATG5 protein]
CTD PMID:26612655 PMID:31306688 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Oleanolic Acid analog results in increased expression of BAX protein
[Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX protein; Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein]]
CTD PMID:26612655 PMID:31401087 PMID:33465424 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Oleanolic Acid analog results in decreased expression of BCL2 protein; Oleanolic Acid results in decreased expression of BCL2 protein
Cisplatin promotes the reaction [Oleanolic Acid results in decreased expression of BCL2 protein]; Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of BCL2 protein]; Oleanolic Acid promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of BCL2 protein]]
CTD PMID:22678527 PMID:26612655 PMID:31306688 PMID:33465424 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 protein CTD PMID:31401087 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Becn1 beclin 1 affects expression ISO Oleanolic Acid analog affects the expression of BECN1 protein CTD PMID:26612655 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Oleanolic Acid results in decreased expression of BIRC5 protein CTD PMID:22678527 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
decreases expression
increases expression
ISO Oleanolic Acid results in increased activity of CASP3 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
Ascorbic Acid inhibits the reaction [Oleanolic Acid results in increased cleavage of CASP3 protein]; Cisplatin inhibits the reaction [Oleanolic Acid results in increased cleavage of CASP3 protein]; Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Oleanolic Acid inhibits the reaction [ochratoxin A results in increased cleavage of CASP3 protein]
Oleanolic Acid analog results in decreased expression of CASP3 protein
Oleanolic Acid results in increased expression of CASP3 protein
CTD PMID:20005942 PMID:20726234 PMID:22678527 PMID:26612655 PMID:31306688 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO Oleanolic Acid results in increased activity of CASP8 protein CTD PMID:20005942 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 decreases expression
multiple interactions
increases cleavage
ISO Oleanolic Acid analog results in decreased expression of CASP9 protein
Oleanolic Acid inhibits the reaction [ochratoxin A results in increased cleavage of CASP9 protein]
Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]
Oleanolic Acid results in increased cleavage of CASP9 protein
CTD PMID:22678527 PMID:26612655 PMID:31306688 PMID:33465424 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases expression
multiple interactions
EXP
ISO
Oleanolic Acid results in increased expression of CAT mRNA
Oleanolic Acid inhibits the reaction [Paraquat results in increased activity of CAT protein]
Oleanolic Acid inhibits the reaction [Ethanol results in increased activity of CAT protein]
Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of CAT protein]
CTD PMID:18706400 PMID:20100471 PMID:21801858 PMID:25111957 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 increases expression
decreases expression
ISO
EXP
Oleanolic Acid results in increased expression of CCND1 mRNA
Oleanolic Acid results in decreased expression of CCND1 protein
CTD PMID:18706400 PMID:20726234 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd274 CD274 molecule multiple interactions ISO [Oleanolic Acid co-treated with gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; [Oleanolic Acid co-treated with gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]] CTD PMID:32894642 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
decreases expression
EXP
ISO
Oleanolic Acid results in increased expression of CDKN1A mRNA
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein]
Oleanolic Acid results in decreased expression of CDKN1A protein
CTD PMID:18706400 PMID:22678527 PMID:31306688 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Oleanolic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein] CTD PMID:32894642 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Oleanolic Acid analog results in decreased expression of COL1A1 mRNA CTD PMID:17922224 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions
ISO Oleanolic Acid results in increased expression of CXCL2 protein
Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of CXCL2 mRNA]; Oleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA]
CTD PMID:25280775 PMID:26513295 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of CXCL1 mRNA] CTD PMID:25280775 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression EXP Oleanolic Acid results in increased expression of CXCL5 mRNA CTD PMID:18706400 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of CYCS protein] CTD PMID:33465424 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases expression
decreases activity
ISO
EXP
Oleanolic Acid inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
Oleanolic Acid results in decreased expression of CYP1A2 mRNA
Oleanolic Acid results in decreased activity of CYP1A2 protein
CTD PMID:15043991 PMID:18706400 PMID:23948738 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO Oleanolic Acid results in decreased expression of CYP27A1 mRNA CTD PMID:23948738 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression ISO Oleanolic Acid results in decreased expression of CYP2B10 mRNA CTD PMID:23948738 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression
ISO
EXP
Oleanolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein]
Oleanolic Acid inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]
Oleanolic Acid results in decreased expression of CYP2E1 mRNA
CTD PMID:10355542 PMID:18706400 PMID:25111957 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 decreases expression ISO Oleanolic Acid results in decreased expression of CYP2F2 mRNA CTD PMID:18706400 NCBI chr 1:82,416,108...82,429,897
Ensembl chr 1:82,416,130...82,429,896
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO Oleanolic Acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]
Oleanolic Acid results in decreased activity of CYP3A4 protein
CTD PMID:15043991 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Oleanolic Acid results in decreased expression of CYP7A1 mRNA; Oleanolic Acid results in decreased expression of CYP7A1 protein CTD PMID:23948738 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Oleanolic Acid results in decreased expression of CYP7B1 mRNA CTD PMID:23948738 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO Oleanolic Acid results in decreased expression of CYP8B1 mRNA; Oleanolic Acid results in decreased expression of CYP8B1 protein CTD PMID:23948738 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of DDIT3 mRNA]
Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of DDIT3 protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of DDIT3 protein]]
CTD PMID:25280775 PMID:33465424 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of GADD45A mRNA] CTD PMID:25280775 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP
ISO
Oleanolic Acid results in increased expression of GCLC mRNA
Oleanolic Acid results in increased expression of GCLC mRNA; Oleanolic Acid results in increased expression of GCLC protein
CTD PMID:18706400 PMID:19283895 PMID:25280775 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Oleanolic Acid results in increased expression of GCLM mRNA CTD PMID:18706400 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide decreases expression ISO Oleanolic Acid results in decreased expression of GHRL protein CTD PMID:20188082 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
JBrowse link
G Gnas GNAS complex locus multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; 4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Calcium; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Cyclic AMP; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols; [Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein CTD PMID:23022524 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 multiple interactions
increases response to substance
ISO [Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased abundance of Calcium; Oleanolic Acid binds to and results in increased activity of GPBAR1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; 4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Calcium; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Cyclic AMP; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols; [Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein; Oleanolic Acid binds to and results in increased activity of GPBAR1 protein
GPBAR1 protein results in increased susceptibility to Oleanolic Acid
CTD PMID:23022524 PMID:23041323 NCBI chr 9:75,862,151...75,863,140
Ensembl chr 9:75,860,677...75,863,168
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Oleanolic Acid inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:10355542 PMID:15720792 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Oleanolic Acid results in increased expression of GPX1 mRNA CTD PMID:18706400 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of and results in decreased activity of GSR protein] CTD PMID:25111957 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO Oleanolic Acid results in decreased expression of HDAC1 protein CTD PMID:20726234 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
decreases response to substance
decreases expression
ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of AGER protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of TNF protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein]; Oleanolic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]
Oleanolic Acid results in decreased susceptibility to HMGB1 protein
Oleanolic Acid results in decreased expression of HMGB1 protein
CTD PMID:22386814 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Oleanolic Acid results in increased expression of HMOX1 mRNA
Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of HMOX1 mRNA]
Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein]
CTD PMID:18706400 PMID:19283895 PMID:25111957 PMID:25280775 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Oleanolic Acid results in increased expression of HSPA1B mRNA CTD PMID:18706400 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein]] CTD PMID:33465424 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
ISO Oleanolic Acid results in decreased expression of ICAM1 protein
Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]
CTD PMID:20005942 PMID:22386814 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of IFNG mRNA] CTD PMID:21801858 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Oleanolic Acid co-treated with gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; [Oleanolic Acid co-treated with gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of RELA protein]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of TET3 mRNA]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of TET3 protein]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]] CTD PMID:32894642 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of IL6 mRNA] CTD PMID:21801858 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Oleanolic Acid co-treated with Glucose] results in increased secretion of INS protein CTD PMID:23022524 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insr insulin receptor multiple interactions EXP [Fructose co-treated with Oleanolic Acid] results in increased expression of INSR mRNA CTD PMID:24704288 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA; [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 protein; Oleanolic Acid inhibits the reaction [Fructose results in increased phosphorylation of IRS1 protein] CTD PMID:24704288 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Lep leptin increases expression ISO Oleanolic Acid results in increased expression of LEP protein CTD PMID:20188082 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO Cisplatin promotes the reaction [Oleanolic Acid results in increased expression of MAP1LC3B protein]; Oleanolic Acid promotes the reaction [Cisplatin results in increased expression of MAP1LC3B protein]
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of MAP1LC3B protein]
CTD PMID:31306688 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MAPK1 protein modified form]
Oleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]
Oleanolic Acid analog results in decreased phosphorylation of MAPK1 protein
CTD PMID:20100471 PMID:26612655 PMID:31306688 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases phosphorylation ISO Oleanolic Acid analog results in decreased phosphorylation of MAPK14 protein CTD PMID:26612655 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MAPK3 protein modified form]
Oleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]
Oleanolic Acid analog results in decreased phosphorylation of MAPK3 protein
CTD PMID:20100471 PMID:26612655 PMID:31306688 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation ISO Oleanolic Acid analog results in decreased phosphorylation of MAPK8 protein CTD PMID:26612655 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Oleanolic Acid results in decreased expression of MET protein CTD PMID:20726234 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions ISO Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of MIF mRNA] CTD PMID:21801858 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased expression of MMP2 mRNA]; Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased secretion of MMP2 protein] CTD PMID:25686905 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions
EXP
ISO
Oleanolic Acid results in increased expression of MT1 mRNA; Oleanolic Acid results in increased expression of MT1A mRNA; Oleanolic Acid results in increased expression of MT1A protein
Oleanolic Acid promotes the reaction [Phalloidine results in increased expression of MT1 mRNA]
CTD PMID:17637929 PMID:18706400 PMID:25280775 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A increases expression EXP
ISO
Oleanolic Acid results in increased expression of MT2 mRNA; Oleanolic Acid results in increased expression of MT2A mRNA; Oleanolic Acid results in increased expression of MT2A protein CTD PMID:17637929 PMID:18706400 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Oleanolic Acid analog results in decreased phosphorylation of MTOR protein CTD PMID:26612655 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
EXP
ISO
Oleanolic Acid results in increased expression of MYC mRNA
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC protein
CTD PMID:18706400 PMID:31401087 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
increases activity
affects localization
ISO
EXP
NFE2L2 protein affects the reaction [Oleanolic Acid results in increased activity of NQO1 protein]; NFE2L2 protein affects the reaction [Oleanolic Acid results in increased expression of NQO1 protein]; Oleanolic Acid promotes the reaction [Phalloidine results in increased expression of NFE2L2 mRNA]; Phalloidine promotes the reaction [Oleanolic Acid results in increased expression of NFE2L2 mRNA]
Oleanolic Acid results in increased expression of NFE2L2 mRNA; Oleanolic Acid results in increased expression of NFE2L2 protein
Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of NFE2L2 protein]; Oleanolic Acid promotes the reaction [Ethanol affects the localization of NFE2L2 protein]
Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NFE2L2 protein]; Oleanolic Acid promotes the reaction [NFE2L2 protein results in increased expression of SREBF1 mRNA]
Oleanolic Acid results in increased activity of NFE2L2 protein
Oleanolic Acid affects the localization of NFE2L2 protein
CTD PMID:18706400 PMID:19283895 PMID:20100471 PMID:23948738 PMID:25111957 More... NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of NFKB1 mRNA CTD PMID:31401087 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions
ISO Oleanolic Acid analog results in decreased phosphorylation of NFKBIA protein
Oleanolic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]
CTD PMID:26612655 PMID:32894642 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
increases activity
ISO
EXP
NFE2L2 protein affects the reaction [Oleanolic Acid results in increased activity of NQO1 protein]; NFE2L2 protein affects the reaction [Oleanolic Acid results in increased expression of NQO1 protein]; Phalloidine promotes the reaction [Oleanolic Acid results in increased expression of NQO1 mRNA]
Oleanolic Acid results in increased expression of NQO1 mRNA; Oleanolic Acid results in increased expression of NQO1 protein
CTD PMID:18706400 PMID:19283895 PMID:23948738 PMID:25280775 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Oleanolic Acid results in decreased expression of NR1H4 mRNA CTD PMID:23948738 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression ISO Oleanolic Acid results in decreased expression of NR1I3 mRNA CTD PMID:23948738 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Oleanolic Acid results in increased expression of ORM1 mRNA CTD PMID:18706400 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Oleanolic Acid analog results in increased cleavage of PARP1 protein; Oleanolic Acid results in increased cleavage of PARP1 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]
Ascorbic Acid inhibits the reaction [Oleanolic Acid results in increased cleavage of PARP1 protein]; Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]
CTD PMID:22678527 PMID:26612655 PMID:31306688 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO
EXP
Oleanolic Acid results in increased expression of PCNA mRNA CTD PMID:18706400 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma multiple interactions EXP [Fructose co-treated with Oleanolic Acid] results in increased expression of PIK3C2G mRNA CTD PMID:24704288 NCBI chr 4:172,483,752...172,851,623
Ensembl chr 4:172,484,345...172,850,544
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases expression ISO Oleanolic Acid analog results in decreased expression of PIK3CA protein CTD PMID:26612655 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Oleanolic Acid results in decreased expression of PPARA mRNA CTD PMID:23948738 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppif peptidylprolyl isomerase F multiple interactions ISO Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of PPIF protein] CTD PMID:33465424 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PRDX1 protein] CTD PMID:20100471 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Oleanolic Acid results in increased expression of PTEN protein CTD PMID:20726234 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Oleanolic Acid results in increased expression of PTGS2 mRNA
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 protein
Oleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; Oleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
CTD PMID:18706400 PMID:26513295 PMID:31401087 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of RELA mRNA; Oleanolic Acid analog results in decreased expression of and affects the localization of RELA protein; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of RELA protein]
Oleanolic Acid analog results in decreased expression of RELA protein
CTD PMID:26362502 PMID:26612655 PMID:31401087 PMID:32894642 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sele selectin E multiple interactions ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of SELE protein] CTD PMID:22386814 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO Oleanolic Acid results in decreased expression of SLC10A1 mRNA; Oleanolic Acid results in decreased expression of SLC10A1 protein CTD PMID:23948738 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc51a solute carrier family 51 subunit alpha decreases expression ISO Oleanolic Acid results in decreased expression of SLC51A mRNA CTD PMID:23948738 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
JBrowse link
G Slc51b solute carrier family 51 subunit beta increases expression ISO Oleanolic Acid results in increased expression of SLC51B mRNA; Oleanolic Acid results in increased expression of SLC51B protein CTD PMID:23948738 NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression ISO Oleanolic Acid results in decreased expression of SLCO1A4 mRNA CTD PMID:23948738 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
multiple interactions
ISO Oleanolic Acid results in decreased expression of SLCO1B2 protein
Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of SLCO1B2 mRNA]
CTD PMID:23948738 PMID:25280775 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions
ISO
EXP
Oleanolic Acid results in increased expression of SOD1 mRNA
Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of SOD1 protein]
CTD PMID:18706400 PMID:25111957 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Oleanolic Acid promotes the reaction [NFE2L2 protein results in increased expression of SREBF1 mRNA] CTD PMID:28796629 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression
multiple interactions
ISO Oleanolic Acid results in increased expression of STAT3 mRNA
Oleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of STAT3 mRNA
CTD PMID:18706400 PMID:31306688 PMID:31401087 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tet3 tet methylcytosine dioxygenase 3 multiple interactions ISO Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of TET3 mRNA]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of TET3 protein]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]] CTD PMID:32894642 NCBI chr 4:115,867,412...115,964,433
Ensembl chr 4:115,871,265...115,964,193
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:21801858 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Oleanolic Acid analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] CTD PMID:17922224 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Oleanolic Acid results in increased expression of TNF mRNA
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of TNF mRNA]
Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of TNF protein]
CTD PMID:18706400 PMID:21801858 PMID:22386814 PMID:31306688 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO Oleanolic Acid results in increased expression of TNFRSF1B mRNA CTD PMID:18706400 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Top1 DNA topoisomerase I decreases activity
decreases expression
ISO Oleanolic Acid results in decreased activity of TOP1 protein
Oleanolic Acid analog results in decreased expression of TOP1 protein
CTD PMID:10860928 PMID:26612655 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity
decreases expression
ISO Oleanolic Acid results in decreased activity of TOP2A protein
Oleanolic Acid analog results in decreased expression of TOP2A protein
CTD PMID:10860928 PMID:26612655 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Trap1 TNF receptor-associated protein 1 multiple interactions ISO Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of TRAP1 protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of BCL2 protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of TRAP1 protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of DDIT3 protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein]] CTD PMID:33465424 NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects binding EXP Oleanolic Acid binds to TRPV1 protein CTD PMID:30496739 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein] CTD PMID:22386814 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        biochemical role 19368
          metabolite 19344
            eukaryotic metabolite 19033
              plant metabolite 17450
                oleanolic acid 106
                  3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 0
                  4-epihederagenin 0
                  acutoside A 0
                  gypsogenin + 0
                  hederagenin + 0
                  oleanolic acid 3-O-[O-beta-D-glucopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->3)-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside] 0
                  oleanolic acid 3-O-beta-D-glucosiduronic acid 0
                  protobassic acid + 0
                  spathodic acid 0
                  spinosic acid A 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        hydroxy carboxylic acid 3656
                                          hydroxy monocarboxylic acid 3656
                                            oleanolic acid 106
                                              3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 0
                                              4-epihederagenin 0
                                              acutoside A 0
                                              gypsogenin + 0
                                              hederagenin + 0
                                              oleanolic acid 3-O-[O-beta-D-glucopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->3)-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside] 0
                                              oleanolic acid 3-O-beta-D-glucosiduronic acid 0
                                              protobassic acid + 0
                                              spathodic acid 0
                                              spinosic acid A 0
paths to the root