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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:clorgyline
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Accession:CHEBI:3763 term browser browse the term
Definition:An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.
Synonyms:exact_synonym: N-[3-(2,4-dichlorophenoxy)propyl]-N-methylprop-2-yn-1-amine
 related_synonym: Formula=C13H15Cl2NO;   InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3;   InChIKey=BTFHLQRNAMSNLC-UHFFFAOYSA-N;   M and B 9302;   M&B 9302;   N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-2-propynylamine;   N-methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine;   SMILES=CN(CCCOc1ccc(Cl)cc1Cl)CC#C;   clorgilina;   clorgiline;   clorgilinum
 xref: CAS:17780-72-2;   DrugBank:DB04017;   KEGG:C11685;   KEGG:D03248;   LINCS:LSM-5808
 xref_mesh: MESH:D003010
 xref: MetaCyc:CPD-7656;   PDBeChem:MLG;   PMID:21079379;   PMID:22203607;   PMID:23546802;   PMID:5119769;   Reaxys:1976758;   Wikipedia:Clorgiline


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clorgyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAOA monoamine oxidase A decreases activity EXP Clorgyline analog results in decreased activity of MAOA protein CTD PMID:33359020 NCBI chr  X:38,930,452...39,006,220 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      application 863
        NMR chemical shift reference compound 419
          ammonia 391
            organic amino compound 284
              tertiary amino compound 69
                clorgyline 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 5052
    subatomic particle 5043
      composite particle 5043
        hadron 5071
          baryon 5043
            nucleon 5043
              atomic nucleus 5043
                atom 5043
                  main group element atom 5013
                    p-block element atom 5010
                      carbon group element atom 4927
                        carbon atom 4954
                          organic molecular entity 4926
                            organic molecule 4874
                              organic cyclic compound 4812
                                carbocyclic compound 245
                                  benzenoid aromatic compound 218
                                    benzenes 211
                                      chlorobenzenes 71
                                        dichlorobenzene 17
                                          clorgyline 1
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