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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nitrogen mustard
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Accession:CHEBI:37598 term browser browse the term
Definition:Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Synonyms:related_synonym: nitrogen mustard compound;   nitrogen mustard compounds;   nitrogen mustards
 alt_id: MESH:D009588
 xref_mesh: MESH:D009588
 xref: Wikipedia:Nitrogen_mustard


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nitrogen mustard term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
decreases expression		 ISO caffeic acid phenethyl ester promotes the reaction [Nitrogen Mustard Compounds results in decreased expression of AHR protein] CTD PMID:17204746 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Alb albumin increases alkylation ISO Nitrogen Mustard Compounds results in increased alkylation of ALB protein CTD PMID:18269793 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
multiple interactions		 ISO Nitrogen Mustard Compounds results in decreased expression of BRCA1 mRNA
Cycloheximide inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of BRCA1 mRNA]		 CTD PMID:10344722 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions
increases expression
decreases expression		 ISO Cycloheximide inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of BRCA2 mRNA]
Nitrogen Mustard Compounds results in increased expression of BRCA2 mRNA		 CTD PMID:10344722 PMID:27342729 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Cdh2 cadherin 2 decreases expression
multiple interactions		 ISO Nitrogen Mustard Compounds results in decreased expression of CDH2 mRNA; Nitrogen Mustard Compounds results in decreased expression of CDH2 protein
Plant Extracts inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of CDH2 mRNA]; Plant Extracts inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of CDH2 protein]		 CTD PMID:18572855 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Dhfr dihydrofolate reductase decreases response to substance ISO DHFR protein polymorphism results in decreased susceptibility to Nitrogen Mustard Compounds CTD PMID:12872145 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO Nitrogen Mustard Compounds results in decreased expression of ERBB2 mRNA CTD PMID:16417271 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Fancd2 FA complementation group D2 increases expression ISO Nitrogen Mustard Compounds results in increased expression of FANCD2 mRNA; Nitrogen Mustard Compounds results in increased expression of FANCD2 protein CTD PMID:27342729 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases response to substance EXP GSTA3 protein results in decreased susceptibility to Nitrogen Mustard Compounds CTD PMID:9414483 PMID:12872145 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression		 ISO MGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of H2AX protein]; Nitrogen Mustard Compounds results in decreased expression of and results in increased phosphorylation of H2AX protein
Nitrogen Mustard Compounds results in increased expression of H2AX mRNA; Nitrogen Mustard Compounds results in increased expression of H2AX protein		 CTD PMID:27342729 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects response to substance ISO IGF1R protein affects the susceptibility to Nitrogen Mustard Compounds CTD PMID:15499378 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions
decreases expression		 ISO MGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of H2AX protein]; MGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of SPRTN protein]
Nitrogen Mustard Compounds results in decreased expression of MGMT mRNA		 CTD PMID:27342729 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions		 ISO Nitrogen Mustard Compounds results in increased expression of NFE2L2 protein
caffeic acid phenethyl ester promotes the reaction [Nitrogen Mustard Compounds results in increased expression of NFE2L2 protein]		 CTD PMID:17204746 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases degradation ISO Nitrogen Mustard Compounds results in increased degradation of NFKBIA protein CTD PMID:17204746 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 multiple interactions
increases phosphorylation		 ISO caffeic acid phenethyl ester inhibits the reaction [Nitrogen Mustard Compounds results in increased phosphorylation of RPS6KA2 protein] CTD PMID:17204746 NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739 		JBrowse link
G Sprtn SprT-like N-terminal domain multiple interactions
increases expression		 ISO MGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of SPRTN protein]
Nitrogen Mustard Compounds results in increased expression of SPRTN mRNA; Nitrogen Mustard Compounds results in increased expression of SPRTN protein		 CTD PMID:27342729 NCBI chr19:52,857,599...52,864,864
Ensembl chr19:52,857,866...52,864,864 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation		 ISO caffeic acid phenethyl ester inhibits the reaction [Nitrogen Mustard Compounds results in increased phosphorylation of TP53 protein] CTD PMID:17204746 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vim vimentin decreases expression ISO Nitrogen Mustard Compounds results in decreased expression of VIM mRNA; Nitrogen Mustard Compounds results in decreased expression of VIM protein CTD PMID:17192600 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 affects response to substance ISO XRCC5 protein affects the susceptibility to Nitrogen Mustard Compounds CTD PMID:10717383 NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018 		JBrowse link
4-hydroperoxycyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase increases expression ISO perfosfamide results in increased expression of ABL1 mRNA CTD PMID:19429390 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Actb actin, beta decreases expression ISO perfosfamide results in decreased expression of ACTB mRNA CTD PMID:19429390 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Agt angiotensinogen decreases response to substance ISO AGT protein results in decreased susceptibility to perfosfamide CTD PMID:11034089 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
increases response to substance		 ISO Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of AIFM1 protein]; perfosfamide results in increased expression of and results in increased localization of AIFM1 protein
AIFM1 results in increased susceptibility to perfosfamide		 CTD PMID:18034189 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 affects response to substance ISO AKR1B10 protein affects the susceptibility to perfosfamide CTD PMID:18473730 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases response to substance ISO ALDH1A1 protein results in decreased susceptibility to perfosfamide CTD PMID:8662658 PMID:16614850 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases response to substance ISO ALDH1A2 protein results in decreased susceptibility to perfosfamide CTD PMID:22079344 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 affects response to substance ISO ALDH1B1 protein affects the susceptibility to perfosfamide CTD PMID:18473730 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases response to substance ISO ALDH2 protein results in decreased susceptibility to perfosfamide CTD PMID:22079344 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 decreases response to substance ISO ALDH3A1 protein results in decreased susceptibility to perfosfamide CTD PMID:16614850 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression EXP perfosfamide results in decreased expression of APEX1 mRNA CTD PMID:11754170 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects folding
increases expression		 ISO Acetylcysteine inhibits the reaction [perfosfamide affects the folding of BAX protein]; Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of BAX]; perfosfamide results in increased expression of and results in increased localization of BAX
perfosfamide results in increased expression of BAX protein		 CTD PMID:16488414 PMID:18034189 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO perfosfamide results in increased expression of BBC3 mRNA CTD PMID:17068108 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B decreases expression ISO perfosfamide results in decreased expression of BMPR1B mRNA CTD PMID:19429390 NCBI chr 2:230,538,252...230,871,077
Ensembl chr 2:230,541,558...230,871,368 		JBrowse link
G C1d C1D nuclear receptor corepressor increases expression ISO perfosfamide results in increased expression of C1D mRNA CTD PMID:19429390 NCBI chr14:91,660,951...91,673,177
Ensembl chr14:91,660,989...91,672,852 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO perfosfamide results in increased activity of CASP3
perfosfamide promotes the reaction [TNF results in increased activity of CASP3 protein]		 CTD PMID:16488414 PMID:17434952 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO perfosfamide results in increased activity of CASP9 protein CTD PMID:16488414 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO perfosfamide results in increased expression of CDKN1A
perfosfamide results in increased expression of CDKN1A mRNA; perfosfamide results in increased expression of CDKN1A protein		 CTD PMID:17068108 PMID:18034189 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression ISO perfosfamide results in decreased expression of CXCL9 mRNA CTD PMID:19429390 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO perfosfamide results in increased expression of E2F1 mRNA CTD PMID:19429390 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Egr1 early growth response 1 decreases expression ISO perfosfamide results in decreased expression of EGR1 mRNA CTD PMID:19429390 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Endog endonuclease G increases response to substance
multiple interactions		 ISO ENDOG results in increased susceptibility to perfosfamide
Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of ENDOG protein]; perfosfamide results in increased expression of and results in increased localization of ENDOG protein		 CTD PMID:18034189 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Epas1 endothelial PAS domain protein 1 increases expression ISO perfosfamide results in increased expression of EPAS1 protein CTD PMID:23251655 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Epha6 Eph receptor A6 decreases expression ISO perfosfamide results in decreased expression of EPHA6 mRNA CTD PMID:19429390 NCBI chr11:39,757,870...40,708,901 JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO perfosfamide results in decreased expression of EYA1 mRNA CTD PMID:19429390 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483 		JBrowse link
G Faslg Fas ligand increases expression ISO perfosfamide results in increased expression of FASLG mRNA; perfosfamide results in increased expression of FASLG protein CTD PMID:14760101 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Foxf1 forkhead box F1 affects expression ISO perfosfamide affects the expression of FOXF1 mRNA CTD PMID:19429390 NCBI chr19:49,153,729...49,157,741
Ensembl chr19:49,153,699...49,157,738 		JBrowse link
G Gjc1 gap junction protein, gamma 1 increases expression ISO perfosfamide results in increased expression of GJC1 mRNA CTD PMID:19429390 NCBI chr10:87,758,192...87,785,443
Ensembl chr10:87,760,528...87,785,867 		JBrowse link
G Gli2 GLI family zinc finger 2 decreases expression ISO perfosfamide results in decreased expression of GLI2 mRNA CTD PMID:19429390 NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression ISO perfosfamide results in increased expression of HES1 mRNA CTD PMID:19429390 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO perfosfamide results in increased expression of HIF1A mRNA; perfosfamide results in increased expression of HIF1A protein CTD PMID:19429390 PMID:23251655 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hoxa11 homeobox A11 decreases expression ISO perfosfamide results in decreased expression of HOXA11 mRNA CTD PMID:19429390 NCBI chr 4:81,342,527...81,346,189
Ensembl chr 4:81,342,528...81,346,232 		JBrowse link
G Hoxa13 homeo box A13 increases expression ISO perfosfamide results in increased expression of HOXA13 mRNA CTD PMID:19429390 NCBI chr 4:81,358,956...81,361,091
Ensembl chr 4:81,358,956...81,361,091 		JBrowse link
G Hoxd10 homeo box D10 increases expression ISO perfosfamide results in increased expression of HOXD10 mRNA CTD PMID:19429390 NCBI chr 3:59,594,516...59,597,725
Ensembl chr 3:59,594,516...59,597,725 		JBrowse link
G Hras HRas proto-oncogene, GTPase decreases expression ISO perfosfamide results in decreased expression of HRAS mRNA CTD PMID:19429390 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Kl Klotho decreases expression ISO perfosfamide results in decreased expression of KL mRNA CTD PMID:19429390 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Lig3 DNA ligase 3 decreases expression EXP perfosfamide results in decreased expression of LIG3 mRNA CTD PMID:11754170 NCBI chr10:67,717,796...67,741,141
Ensembl chr10:67,717,812...67,798,414 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO perfosfamide results in increased expression of MDM2 CTD PMID:18034189 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression EXP perfosfamide results in decreased expression of MGMT mRNA CTD PMID:11754170 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mlh1 mutL homolog 1 decreases expression EXP perfosfamide results in decreased expression of MLH1 mRNA CTD PMID:11754170 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase decreases expression EXP perfosfamide results in decreased expression of MPG mRNA CTD PMID:11754170 NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression EXP perfosfamide results in decreased expression of MRE11A mRNA CTD PMID:11754170 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Myo1b myosin Ib increases expression ISO perfosfamide results in increased expression of MYO1B mRNA CTD PMID:19429390 NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798 		JBrowse link
G Myog myogenin increases expression ISO perfosfamide results in increased expression of MYOG mRNA CTD PMID:19429390 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039 		JBrowse link
G Ndn necdin, MAGE family member increases expression ISO perfosfamide results in increased expression of NDN mRNA CTD PMID:19429390 NCBI chr 1:115,849,168...115,850,767
Ensembl chr 1:115,849,105...115,850,767 		JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression ISO perfosfamide results in decreased expression of ODC1 mRNA CTD PMID:19429390 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 decreases expression ISO perfosfamide results in decreased expression of PEA15 mRNA CTD PMID:19429390 NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO perfosfamide results in increased expression of PMAIP1 mRNA CTD PMID:17068108 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component decreases expression EXP perfosfamide results in decreased expression of PMS1 mRNA CTD PMID:11754170 NCBI chr 9:48,229,403...48,340,237
Ensembl chr 9:48,253,410...48,340,237 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component decreases expression EXP perfosfamide results in decreased expression of PMS2 mRNA CTD PMID:11754170 NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Polb DNA polymerase beta decreases expression EXP perfosfamide results in decreased expression of POLB mRNA CTD PMID:11754170 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Pold1 DNA polymerase delta 1, catalytic subunit decreases expression ISO perfosfamide results in decreased expression of POLD1 mRNA CTD PMID:19429390 NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465 		JBrowse link
G Rad21 RAD21 cohesin complex component decreases expression ISO perfosfamide results in decreased expression of RAD21 mRNA CTD PMID:19429390 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817 		JBrowse link
G Rad50 RAD50 double strand break repair protein decreases expression EXP perfosfamide results in decreased expression of RAD50 mRNA CTD PMID:11754170 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Rad51 RAD51 recombinase decreases expression EXP perfosfamide results in decreased expression of RAD51 mRNA CTD PMID:11754170 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Sdf4 stromal cell derived factor 4 decreases expression ISO perfosfamide results in decreased expression of SDF4 mRNA CTD PMID:19429390 NCBI chr 5:166,586,581...166,606,661
Ensembl chr 5:166,586,390...166,604,521 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 decreases expression ISO perfosfamide results in decreased expression of SFRP2 mRNA CTD PMID:19429390 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
G Slc30a4 solute carrier family 30 member 4 decreases expression ISO perfosfamide results in decreased expression of SLC30A4 mRNA CTD PMID:19429390 NCBI chr 3:109,753,270...109,775,306
Ensembl chr 3:109,753,273...109,775,306 		JBrowse link
G Smad1 SMAD family member 1 decreases expression ISO perfosfamide results in decreased expression of SMAD1 mRNA CTD PMID:19429390 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member affects response to substance ISO TAP1 protein affects the susceptibility to perfosfamide CTD PMID:18473730 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901 		JBrowse link
G Tcf12 transcription factor 12 increases expression ISO perfosfamide results in increased expression of TCF12 mRNA CTD PMID:19429390 NCBI chr 8:72,490,447...72,799,265
Ensembl chr 8:72,492,567...72,799,201 		JBrowse link
G Terc telomerase RNA component decreases expression ISO perfosfamide results in decreased expression of TERC mRNA CTD PMID:24571982 NCBI chr 2:112,815,654...112,816,041 JBrowse link
G Tert telomerase reverse transcriptase decreases expression ISO perfosfamide results in decreased expression of TERT mRNA CTD PMID:24571982 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO perfosfamide promotes the reaction [TNF results in increased activity of CASP3 protein] CTD PMID:16488414 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [perfosfamide results in increased expression of TP53]
perfosfamide results in increased expression of and results in increased phosphorylation of and results in increased activity of TRP53 protein		 CTD PMID:17068108 PMID:18034189 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trim27 tripartite motif-containing 27 decreases expression ISO perfosfamide results in decreased expression of TRIM27 mRNA CTD PMID:19429390 NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643 		JBrowse link
G Ttf1 transcription termination factor 1 decreases expression ISO perfosfamide results in decreased expression of TTF1 mRNA CTD PMID:19429390 NCBI chr 3:12,384,626...12,409,257
Ensembl chr 3:12,384,655...12,409,257 		JBrowse link
G Ubb ubiquitin B decreases expression ISO perfosfamide results in decreased expression of UBB mRNA CTD PMID:19429390 NCBI chr10:47,247,629...47,249,335
Ensembl chr10:47,245,637...47,249,333 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO perfosfamide results in increased expression of VEGFA mRNA CTD PMID:19429390 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin decreases expression ISO perfosfamide results in decreased expression of VIM mRNA CTD PMID:19429390 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Wnt11 Wnt family member 11 increases expression ISO perfosfamide results in increased expression of WNT11 mRNA CTD PMID:19429390 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases expression EXP perfosfamide results in decreased expression of XRCC1 mRNA CTD PMID:11754170 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression EXP perfosfamide results in decreased expression of XRCC5 mRNA CTD PMID:11754170 NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta decreases expression ISO perfosfamide results in decreased expression of YWHAZ mRNA CTD PMID:19429390 NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668 		JBrowse link
4-hydroxycyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of ALOX5 mRNA CTD PMID:25833159 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of BDKRB2 mRNA CTD PMID:25833159 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Cd40 CD40 molecule multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of CD40 mRNA CTD PMID:25833159 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases chemical synthesis ISO CYP2B6 protein results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:24819615 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases chemical synthesis ISO CYP2C9 protein results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:24819615 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP2C19 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:30500380 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:30500380 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL1R1 mRNA CTD PMID:25833159 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL2RG mRNA CTD PMID:25833159 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Klk15 kallikrein-related peptidase 15 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of KLK15 mRNA CTD PMID:25833159 NCBI chr 1:94,699,422...94,706,626
Ensembl chr 1:94,703,158...94,706,329
Ensembl chr 1:94,703,158...94,706,329 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of MAPK14 mRNA CTD PMID:25833159 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
Aldophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
increases oxidation		 ISO [ALDH1A1 protein co-treated with NAD] results in increased oxidation of aldophosphamide
ALDH1A1 results in increased oxidation of aldophosphamide		 CTD PMID:8662658 PMID:10856427 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions ISO [ALDH3A1 protein co-treated with NAD] results in increased oxidation of aldophosphamide; [ALDH3A1 protein co-treated with NADP] results in increased oxidation of aldophosphamide CTD PMID:10856427 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
chlorambucil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Chlorambucil results in increased expression of ABCB1 protein CTD PMID:15239124 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects export
decreases response to substance
increases response to substance
multiple interactions		 ISO ABCC1 protein affects the export of Chlorambucil analog
ABCC1 protein results in decreased susceptibility to Chlorambucil
ABCC1 protein results in increased susceptibility to Chlorambucil
buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased susceptibility to Chlorambucil]; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Chlorambucil]		 CTD PMID:10900222 PMID:11115505 PMID:12504668 PMID:14569069 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
multiple interactions		 ISO ABCC2 protein affects the export of Chlorambucil analog
ABCC2 protein promotes the reaction [GSTA1 protein results in decreased susceptibility to Chlorambucil]		 CTD PMID:14569069 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases expression ISO Chlorambucil results in decreased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases expression ISO Chlorambucil results in decreased expression of AKR1C2 mRNA CTD PMID:26198647 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Asf1a anti-silencing function 1A histone chaperone decreases expression ISO Chlorambucil results in decreased expression of ASF1A mRNA CTD PMID:26198647 NCBI chr20:32,893,962...32,908,808
Ensembl chr20:32,893,573...32,908,808 		JBrowse link
G Aurka aurora kinase A increases expression ISO Chlorambucil results in increased expression of AURKA protein CTD PMID:22025197 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Aurkb aurora kinase B decreases expression ISO Chlorambucil results in decreased expression of AURKB protein CTD PMID:22025197 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Chlorambucil results in increased expression of BAX protein CTD PMID:11699414 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Chlorambucil results in increased expression of BBC3 mRNA CTD PMID:17476690 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Chlorambucil results in decreased expression of BCL2 mRNA; Chlorambucil results in decreased expression of BCL2 protein
IL4 protein inhibits the reaction [Chlorambucil results in decreased expression of BCL2 protein]		 CTD PMID:8822937 PMID:11699414 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bik BCL2-interacting killer increases expression ISO Chlorambucil results in increased expression of BIK mRNA CTD PMID:26198647 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases response to substance ISO BIRC2 protein results in decreased susceptibility to Chlorambucil CTD PMID:10815900 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects expression
decreases expression		 ISO Chlorambucil affects the expression of BIRC5 mRNA
Chlorambucil results in decreased expression of BIRC5 protein		 CTD PMID:17476690 PMID:22025197 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp5 bone morphogenetic protein 5 increases mutagenesis ISO Chlorambucil results in increased mutagenesis of BMP5 gene CTD PMID:10517996 NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925 		JBrowse link
G Casp3 caspase 3 increases activity ISO Chlorambucil results in increased activity of CASP3 protein CTD PMID:11675354 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO Chlorambucil results in increased activity of CASP8 protein CTD PMID:11675354 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cd59 CD59 molecule decreases lipidation EXP Chlorambucil results in decreased lipidation of CD59 protein CTD PMID:27931811 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cda cytidine deaminase decreases response to substance ISO CDA protein results in decreased susceptibility to Chlorambucil CTD PMID:10830723 NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO Chlorambucil analog results in increased phosphorylation of and results in decreased activity of CDK1 protein CTD PMID:16861886 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Chlorambucil results in increased expression of CDKN1A protein CTD PMID:16039525 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Dhfr dihydrofolate reductase decreases response to substance ISO DHFR protein polymorphism results in decreased susceptibility to Chlorambucil CTD PMID:12872145 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Ednrb endothelin receptor type B increases mutagenesis ISO Chlorambucil results in increased mutagenesis of EDNRB gene CTD PMID:10517996 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Fancc FA complementation group C increases response to substance ISO FANCC protein results in increased susceptibility to Chlorambucil CTD PMID:16243825 NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376 		JBrowse link
G Fancg FA complementation group G increases response to substance ISO FANCG protein results in increased susceptibility to Chlorambucil CTD PMID:16243825 NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Chlorambucil results in increased expression of FAS mRNA CTD PMID:11675354 PMID:17476690 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fbxo30 F-box protein 30 decreases expression ISO Chlorambucil results in decreased expression of FBXO30 mRNA CTD PMID:26198647 NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Chlorambucil CTD PMID:10900222 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Chlorambucil CTD PMID:10900222 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity
decreases response to substance
multiple interactions		 ISO Chlorambucil analog results in decreased activity of GSTA1 protein
GSTA1 protein results in decreased susceptibility to Chlorambucil
ABCC2 protein promotes the reaction [GSTA1 protein results in decreased susceptibility to Chlorambucil]; GSTA1 protein affects the metabolism of [Chlorambucil co-treated with Glutathione]		 CTD PMID:11115505 PMID:14569069 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases response to substance EXP GSTA3 protein results in decreased susceptibility to Chlorambucil CTD PMID:8044793 PMID:8860835 PMID:10830723 PMID:12872145 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases response to substance EXP GSTA5 protein results in decreased susceptibility to Chlorambucil CTD PMID:12076520 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases response to substance ISO GSTM1 protein results in decreased susceptibility to Chlorambucil CTD PMID:15044619 PMID:20067466 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects binding
increases metabolic processing
decreases response to substance
affects response to substance
multiple interactions		 ISO Chlorambucil binds to GSTP1 protein
GSTP1 protein results in increased metabolism of Chlorambucil
GSTP1 protein results in decreased susceptibility to Chlorambucil
GSTP1 gene affects the susceptibility to Chlorambucil
GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Chlorambucil]		 CTD PMID:10900222 PMID:11071881 PMID:18511072 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Chlorambucil analog results in increased phosphorylation of H2AX protein; Chlorambucil results in increased phosphorylation of H2AX protein CTD PMID:16861886 PMID:32482060 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G H4c3 H4 clustered histone 3 decreases expression ISO Chlorambucil analog results in decreased expression of H4C3 mRNA; Chlorambucil results in decreased expression of H4C3 mRNA; Chlorambucil results in decreased expression of H4C3 protein CTD PMID:15556009 PMID:16861886
G Il4 interleukin 4 multiple interactions ISO IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein]; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of TP53]; IL4 protein inhibits the reaction [Chlorambucil results in decreased expression of BCL2 protein] CTD PMID:8822937 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil] CTD PMID:19608619 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Chlorambucil results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Chlorambucil results in increased expression of MDM2 mRNA CTD PMID:17476690 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
affects expression
increases expression		 ISO [Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein]
Chlorambucil affects the expression of MYC mRNA
Chlorambucil results in increased expression of MYC protein		 CTD PMID:8822937 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myo5a myosin VA increases mutagenesis ISO Chlorambucil results in increased mutagenesis of MYO5A gene CTD PMID:10517996 NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects response to substance
increases response to substance		 ISO [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil]
[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Chlorambucil
Buthionine Sulfoximine affects the reaction [[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Chlorambucil]; Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Chlorambucil]]; NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Chlorambucil]
NFE2L2 gene mutant form results in increased susceptibility to Chlorambucil		 CTD PMID:19303893 PMID:19608619 PMID:20932822 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 affects expression ISO Chlorambucil affects the expression of PDK4 mRNA CTD PMID:32870474 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A increases mutagenesis
multiple interactions		 EXP Chlorambucil results in increased mutagenesis of PIGA
Chlorambucil results in increased mutagenesis of and results in decreased activity of PIGA protein		 CTD PMID:22923490 PMID:27931811 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804 		JBrowse link
G Rad51 RAD51 recombinase increases expression ISO Chlorambucil results in increased expression of RAD51 protein CTD PMID:10473103 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Chlorambucil affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,760,631...4,770,662 JBrowse link
G Sfn stratifin increases expression ISO Chlorambucil results in increased expression of SFN mRNA CTD PMID:18092340 Ensembl chr 5:145,826,201...145,831,314 JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b affects expression ISO Chlorambucil affects the expression of TNFRSF10A mRNA CTD PMID:14614459 NCBI chr15:44,839,818...44,867,582 JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO Chlorambucil results in increased expression of TP53; Chlorambucil results in increased expression of TP53 protein
[Theophylline co-treated with Chlorambucil] results in increased expression of TP53; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of TP53]		 CTD PMID:8822937 PMID:18092340 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity EXP Chlorambucil results in decreased activity of TXNRD1 protein CTD PMID:16085187 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases mutagenesis ISO Chlorambucil results in increased mutagenesis of TYRP1 gene CTD PMID:10517996 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
cyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases expression
increases expression		 ISO
EXP		 [Cyclophosphamide results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; ABCB1 protein affects the susceptibility to [Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil]; ABCB1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; NR1I2 protein promotes the reaction [Cyclophosphamide results in increased expression of ABCB1 protein]
Cyclophosphamide results in decreased expression of ABCB1 mRNA; Cyclophosphamide results in decreased expression of ABCB1A mRNA		 CTD PMID:12576456 PMID:20041327 PMID:20623750 PMID:30563925 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases response to substance		 ISO ABCC1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]
ABCC1 protein results in decreased susceptibility to Cyclophosphamide		 CTD PMID:11778547 PMID:12576456 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO ABCG2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:12576456 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Abhd3 abhydrolase domain containing 3, phospholipase increases expression ISO Cyclophosphamide results in increased expression of ABHD3 mRNA CTD PMID:21527772 NCBI chr18:1,723,203...1,778,488
Ensembl chr18:1,720,718...1,803,428 		JBrowse link
G Abi2 abl-interactor 2 decreases expression EXP Cyclophosphamide results in decreased expression of ABI2 mRNA CTD PMID:27466211 NCBI chr 9:61,856,379...61,904,029
Ensembl chr 9:61,827,139...61,905,699 		JBrowse link
G Ace angiotensin I converting enzyme decreases expression EXP Cyclophosphamide results in decreased expression of ACE mRNA CTD PMID:27281708 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO Cyclophosphamide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Ackr3 atypical chemokine receptor 3 increases expression EXP Cyclophosphamide results in increased expression of ACKR3 mRNA CTD PMID:20032115 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237 		JBrowse link
G Acod1 aconitate decarboxylase 1 increases expression ISO Cyclophosphamide results in increased expression of ACOD1 mRNA CTD PMID:15331540 NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529 		JBrowse link
G Actb actin, beta decreases expression
affects expression		 ISO
EXP		 Cyclophosphamide results in decreased expression of ACTB mRNA
Cyclophosphamide affects the expression of ACTB mRNA		 CTD PMID:10859244 PMID:12167460 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Adam24 a disintegrin and metallopeptidase domain 24 decreases expression EXP Cyclophosphamide results in decreased expression of ADAM24 mRNA CTD PMID:27281708 NCBI chr16:51,578,278...51,584,342
Ensembl chr16:51,578,277...51,584,312 		JBrowse link
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 increases expression EXP Cyclophosphamide results in increased expression of ADAMTS9 mRNA CTD PMID:27281708 NCBI chr 4:125,290,633...125,462,988
Ensembl chr 4:125,291,490...125,462,929 		JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 affects expression
increases expression		 EXP Cyclophosphamide affects the expression of ADCYAP1 mRNA
Cyclophosphamide results in increased expression of ADCYAP1 protein		 CTD PMID:9776515 PMID:10754506 PMID:18563302 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Adcyap1r1 ADCYAP receptor type I affects expression EXP Cyclophosphamide affects the expression of ADCYAP1R1 mRNA CTD PMID:18563302 NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700 		JBrowse link
G Adm adrenomedullin affects response to substance ISO ADM protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Afp alpha-fetoprotein affects expression ISO Cyclophosphamide affects the expression of AFP protein CTD PMID:6177358 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Agl amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase affects response to substance ISO AGL protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 2:204,705,053...204,760,966
Ensembl chr 2:204,705,053...204,760,828 		JBrowse link
G Akap2 A-kinase anchoring protein 2 increases expression ISO Cyclophosphamide results in increased expression of PALM2AKAP2 mRNA CTD PMID:17403535 NCBI chr 5:72,536,986...72,648,524
Ensembl chr 5:72,181,718...72,648,524 		JBrowse link
G Akap8 A-kinase anchoring protein 8 increases expression EXP Cyclophosphamide results in increased expression of AKAP8 mRNA CTD PMID:27281708 NCBI chr 7:11,316,224...11,332,523
Ensembl chr 7:11,316,228...11,332,399 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression		 EXP Cyclophosphamide results in increased phosphorylation of and results in increased activity of AKT1 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of AKT1 protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of AKT1 protein] CTD PMID:19996110 PMID:25446862 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alad aminolevulinate dehydratase multiple interactions ISO [Cyclophosphamide co-treated with Carmustine co-treated with Etoposide] results in decreased activity of ALAD protein CTD PMID:19162187 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alcam activated leukocyte cell adhesion molecule increases expression ISO Cyclophosphamide results in increased expression of ALCAM mRNA CTD PMID:21041162 NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects response to substance
increases expression
decreases response to substance		 ISO ALDH1A1 protein affects the susceptibility to Cyclophosphamide
Cyclophosphamide results in increased expression of ALDH1A1 mRNA
ALDH1A1 protein results in decreased susceptibility to Cyclophosphamide		 CTD PMID:12513786 PMID:17403535 PMID:18854779 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member increases expression ISO Cyclophosphamide results in increased expression of ALDH2 mRNA CTD PMID:17403535 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 affects response to substance ISO ALDH3A1 protein affects the susceptibility to Cyclophosphamide CTD PMID:18854779 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein decreases expression ISO Cyclophosphamide results in decreased expression of ALOX5AP mRNA CTD PMID:17403535 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Alyref Aly/REF export factor decreases expression ISO Cyclophosphamide results in decreased expression of ALYREF mRNA CTD PMID:21041162 NCBI chr10:105,871,306...105,875,076
Ensembl chr10:105,871,306...105,875,069 		JBrowse link
G Amfr autocrine motility factor receptor multiple interactions ISO AMFR mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247 		JBrowse link
G Angpt1 angiopoietin 1 increases expression ISO Cyclophosphamide results in increased expression of ANGPT1 mRNA CTD PMID:17403535 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression ISO Cyclophosphamide results in decreased expression of APAF1 mRNA CTD PMID:29445054 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Cyclophosphamide results in increased expression of APEX1 mRNA CTD PMID:11599041 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Apob apolipoprotein B decreases expression EXP Cyclophosphamide results in decreased expression of APOB mRNA CTD PMID:18246545 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoe apolipoprotein E decreases expression
increases expression		 ISO Cyclophosphamide results in decreased expression of APOE mRNA
Cyclophosphamide results in increased expression of APOE mRNA		 CTD PMID:15331540 PMID:21041162 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Arg1 arginase 1 increases expression
decreases expression
affects expression		 ISO
EXP		 Cyclophosphamide results in increased expression of ARG1 mRNA
Cyclophosphamide results in decreased expression of ARG1 mRNA
Cyclophosphamide affects the expression of ARG1 mRNA		 CTD PMID:18246545 PMID:21068404 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta increases expression ISO Cyclophosphamide results in increased expression of ARHGDIB mRNA CTD PMID:21527772 NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658 		JBrowse link
G Arhgef26 Rho guanine nucleotide exchange factor 26 increases expression ISO Cyclophosphamide results in increased expression of ARHGEF26 mRNA CTD PMID:20849824 NCBI chr 2:146,740,336...146,850,918
Ensembl chr 2:146,739,631...146,850,819 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Cyclophosphamide metabolite results in decreased expression of ASNS mRNA CTD PMID:24356939 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Atf2 activating transcription factor 2 increases expression EXP Cyclophosphamide results in increased expression of ATF2 mRNA CTD PMID:11599041 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Atf5 activating transcription factor 5 decreases expression ISO Cyclophosphamide results in decreased expression of ATF5 mRNA CTD PMID:17403535 NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707 		JBrowse link
G Atg3 autophagy related 3 decreases expression ISO Cyclophosphamide results in decreased expression of ATG3 mRNA CTD PMID:20849824 NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224 		JBrowse link
G Atg5 autophagy related 5 decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased expression of ATG5 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of ATG5 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG5 protein]		 CTD PMID:32151603 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased expression of ATG7 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of ATG7 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG7 protein]		 CTD PMID:32151603 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Aurkb aurora kinase B increases expression EXP Cyclophosphamide results in increased expression of AURKB mRNA CTD PMID:11599041 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO Cyclophosphamide results in increased expression of AXL mRNA CTD PMID:21527772 NCBI chr 1:81,265,656...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G B3galnt2 beta-1,3-N-acetylgalactosaminyltransferase 2 increases expression ISO Cyclophosphamide results in increased expression of B3GALNT2 mRNA CTD PMID:21527772 NCBI chr17:51,334,921...51,377,469
Ensembl chr17:51,334,921...51,377,469 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions		 EXP
ISO		 Cyclophosphamide results in increased expression of BAD mRNA
Cyclophosphamide results in increased expression of BAD protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased expression of BAD protein]		 CTD PMID:11599041 PMID:29753871 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bag1 BAG cochaperone 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BAG1 mRNA CTD PMID:16322899 NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP
ISO		 Cyclophosphamide results in increased expression of BAX mRNA; Cyclophosphamide results in increased expression of BAX protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]
Plant Extracts inhibits the reaction [Cyclophosphamide results in increased expression of BAX mRNA]; sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]		 CTD PMID:25446862 PMID:29753871 PMID:30506662 PMID:32197949 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression
multiple interactions		 EXP Cyclophosphamide results in increased expression of BBC3 mRNA
sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in increased expression of BBC3 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BBC3 mRNA]		 CTD PMID:32197949 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 multiple interactions ISO BBS4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 8:59,731,912...59,765,408
Ensembl chr 8:59,731,912...59,765,607 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity		 ISO [Melphalan co-treated with Thiotepa co-treated with Cyclophosphamide] results in decreased expression of BCHE protein
Cyclophosphamide results in decreased activity of BCHE protein		 CTD PMID:4672170 PMID:4959505 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression		 ISO
EXP		 [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of BCL2 protein; [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BCL2 mRNA; [Doxorubicin co-treated with Dexamethasone co-treated with Vincristine co-treated with Cytarabine co-treated with Mercaptopurine co-treated with Methotrexate co-treated with Cyclophosphamide co-treated with Enzymes and Coenzymes] results in increased expression of BCL2 protein; BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP9 protein]
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]
Cyclophosphamide results in decreased expression of BCL2 mRNA; Cyclophosphamide results in decreased expression of BCL2 protein
Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 mRNA]; sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]
Cyclophosphamide results in increased expression of BCL2 mRNA		 CTD PMID:11723234 PMID:14503796 PMID:15582267 PMID:16322899 PMID:21182165 More... NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
decreases expression		 EXP
ISO		 Cyclophosphamide results in increased expression of BCL2L1 mRNA
Cyclophosphamide results in decreased expression of BCL2L1 mRNA		 CTD PMID:11599041 PMID:33737021 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 BCL2 like 11 increases expression
multiple interactions		 EXP Cyclophosphamide results in increased expression of BCL2L11 mRNA
sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in increased expression of BCL2L11 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BCL2L11 mRNA]		 CTD PMID:32197949 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression ISO Cyclophosphamide results in increased expression of BCL2L2 mRNA CTD PMID:21041162 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bcl6 BCL6, transcription repressor decreases expression ISO Cyclophosphamide results in decreased expression of BCL6 mRNA
Cyclophosphamide metabolite results in decreased expression of BCL6 mRNA		 CTD PMID:21041162 PMID:24356939 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 affects response to substance ISO BDH1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671 		JBrowse link
G Bdkrb1 bradykinin receptor B1 increases expression EXP Cyclophosphamide results in increased expression of BDKRB1 mRNA CTD PMID:10498854 PMID:15576455 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 affects expression EXP Cyclophosphamide affects the expression of BDKRB2 mRNA CTD PMID:15576455 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Cyclophosphamide results in increased expression of BDNF mRNA CTD PMID:10683293 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions
decreases expression		 ISO BECN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of BECN1 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of BECN1 protein]		 CTD PMID:16896004 PMID:32151603 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bik BCL2-interacting killer decreases expression ISO Cyclophosphamide results in decreased expression of BIK mRNA CTD PMID:17403535 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of BIRC3 mRNA CTD PMID:24356939 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Blvrb biliverdin reductase B decreases expression EXP Cyclophosphamide results in decreased expression of BLVRB protein CTD PMID:9006340 NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375 		JBrowse link
G Bpi bactericidal/permeability-increasing protein decreases expression ISO Cyclophosphamide results in decreased expression of BPI mRNA CTD PMID:17403535 NCBI chr 3:146,909,626...146,936,487
Ensembl chr 3:146,909,629...146,936,221 		JBrowse link
G Brpf1 bromodomain and PHD finger containing, 1 increases expression EXP Cyclophosphamide results in increased expression of BRPF1 mRNA CTD PMID:27281708 NCBI chr 4:146,456,344...146,472,781
Ensembl chr 4:146,456,318...146,472,649 		JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO Cyclophosphamide results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr 1:205,731,814...205,743,430
Ensembl chr 1:205,733,872...205,743,421 		JBrowse link
G Bsg basigin (Ok blood group) decreases expression ISO Cyclophosphamide results in decreased expression of BSG mRNA CTD PMID:15331540 NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO Cyclophosphamide results in decreased expression of BTG1 mRNA CTD PMID:21041162 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Cyclophosphamide results in increased expression of BTG2 mRNA CTD PMID:29445054 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G Btg3 BTG anti-proliferation factor 3 multiple interactions ISO BTG3 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170 		JBrowse link
G Bub3 BUB3 mitotic checkpoint protein multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BUB3 mRNA CTD PMID:16322899 NCBI chr 1:186,330,358...186,340,969
Ensembl chr 1:186,327,931...186,395,036 		JBrowse link
G C1qa complement C1q A chain increases expression ISO Cyclophosphamide results in increased expression of C1QA mRNA CTD PMID:21041162 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C3 complement C3 increases expression ISO Cyclophosphamide results in increased expression of C3 mRNA CTD PMID:21041162 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Ca12 carbonic anhydrase 12 multiple interactions ISO CA12 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440 		JBrowse link
G Cabp1 calcium binding protein 1 decreases expression EXP Cyclophosphamide results in decreased expression of CABP1 mRNA CTD PMID:11906922 NCBI chr12:41,385,234...41,448,930
Ensembl chr12:41,378,897...41,448,927 		JBrowse link
G Cabp2 calcium binding protein 2 decreases expression EXP Cyclophosphamide results in decreased expression of CABP2 mRNA CTD PMID:11906922 NCBI chr 1:201,374,649...201,380,469
Ensembl chr 1:201,375,276...201,380,469 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases expression
multiple interactions		 ISO Cyclophosphamide results in increased expression of CACNA1H protein
3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein		 CTD PMID:29129814 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Calr calreticulin increases expression
decreases expression		 EXP Cyclophosphamide results in increased expression of CALR mRNA
Cyclophosphamide results in decreased expression of CALR mRNA		 CTD PMID:11599041 PMID:11906922 PMID:18246545 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Canx calnexin decreases expression EXP Cyclophosphamide results in decreased expression of CANX mRNA CTD PMID:11906922 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821 		JBrowse link
G Capn2 calpain 2 increases expression ISO Cyclophosphamide results in increased expression of CAPN2 mRNA CTD PMID:21041162 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Car2 carbonic anhydrase 2 decreases expression
increases expression		 ISO Cyclophosphamide results in decreased expression of CA2 mRNA
Cyclophosphamide results in increased expression of CAR2 mRNA		 CTD PMID:15331540 PMID:17403535 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Car7 carbonic anhydrase 7 decreases expression EXP Cyclophosphamide results in decreased expression of CAR7 mRNA CTD PMID:27281708 NCBI chr19:429,063...438,478
Ensembl chr19:429,075...438,467 		JBrowse link
G Cars cysteinyl-tRNA synthetase decreases expression ISO Cyclophosphamide metabolite results in decreased expression of CARS1 mRNA CTD PMID:24356939 NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941 		JBrowse link
G Casp1 caspase 1 decreases expression
increases expression		 ISO Cyclophosphamide results in decreased expression of CASP1 mRNA
Cyclophosphamide results in increased expression of CASP1 mRNA		 CTD PMID:17403535 PMID:21041162 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
decreases response to substance		 ISO
EXP		 [Bortezomib co-treated with oblimersen co-treated with Cyclophosphamide] results in increased activity of CASP3 protein; BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]; Cyclophosphamide results in increased cleavage of and results in increased activity of CASP3 protein
sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]
Cyclophosphamide results in increased expression of CASP3 protein
ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 protein]
Cyclophosphamide results in increased expression of CASP3 mRNA
CASP3 protein alternative form results in decreased susceptibility to Cyclophosphamide		 CTD PMID:11723234 PMID:14503796 PMID:16675587 PMID:17020986 PMID:17898787 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 increases cleavage
multiple interactions		 EXP Cyclophosphamide results in increased cleavage of CASP4 protein
sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP4 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP4 protein]		 CTD PMID:32197949 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases response to substance		 ISO [Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Cyclophosphamide metabolite; Cyclophosphamide metabolite results in increased expression of and results in increased cleavage of CASP8 protein; Cyclophosphamide results in increased cleavage of and results in increased activity of CASP8 protein
CASP8 protein results in increased susceptibility to Cyclophosphamide metabolite		 CTD PMID:17898787 PMID:22010212 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity		 ISO
EXP		 BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP9 protein]; Cyclophosphamide results in increased cleavage of and results in increased activity of CASP9 protein
ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of CASP9 protein]		 CTD PMID:11723234 PMID:17898787 PMID:30506662 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression
decreases activity
affects activity
multiple interactions		 EXP
ISO		 Cyclophosphamide results in decreased expression of CAT protein
Cyclophosphamide results in decreased activity of CAT protein
Cyclophosphamide results in decreased expression of CAT mRNA; Cyclophosphamide results in decreased expression of CAT protein
Cyclophosphamide affects the activity of CAT protein
Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of CAT protein]; cinnamic acid inhibits the reaction [Cyclophosphamide affects the activity of CAT protein]; Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of CAT protein]; Eicosapentaenoic Acid inhibits the reaction [Cyclophosphamide affects the activity of CAT protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of CAT protein]]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of CAT mRNA]
mangiferin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; naringin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; Pentoxifylline inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; pimagedine inhibits the reaction [Cyclophosphamide results in decreased expression of CAT protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]		 CTD PMID:16076520 PMID:19107871 PMID:20052769 PMID:20957680 PMID:21772021 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccin calicin increases expression ISO Cyclophosphamide results in increased expression of CCIN protein CTD PMID:17475930 NCBI chr 5:58,206,676...58,208,563
Ensembl chr 5:58,206,633...58,208,951 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
increases expression		 EXP
ISO		 Cyclophosphamide results in decreased expression of CCL2 protein
naringin inhibits the reaction [Cyclophosphamide results in increased expression of CCL2 mRNA]		 CTD PMID:18848347 PMID:21068404 PMID:33992719 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl25 C-C motif chemokine ligand 25 decreases expression ISO Cyclophosphamide results in decreased expression of CCL25 mRNA CTD PMID:21041162 NCBI chr12:2,707,398...2,716,571
Ensembl chr12:2,707,398...2,716,554 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Cyclophosphamide results in decreased expression of CCL3 protein CTD PMID:21880982 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO Cyclophosphamide results in increased expression of CCL7 mRNA CTD PMID:15331540 PMID:21041162 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Cyclophosphamide results in decreased expression of CCNA2 mRNA CTD PMID:21041162 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Cyclophosphamide results in decreased expression of CCND1 protein CTD PMID:33737021 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 increases expression ISO Cyclophosphamide results in increased expression of CCND2 mRNA CTD PMID:21041162 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Cyclophosphamide results in decreased expression of CCND3 mRNA CTD PMID:21041162 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Cyclophosphamide results in increased expression of CCR5 mRNA CTD PMID:15331540 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Ccr8 C-C motif chemokine receptor 8 decreases expression ISO Cyclophosphamide results in decreased expression of CCR8 mRNA CTD PMID:17403535 NCBI chr 8:119,826,332...119,828,292
Ensembl chr 8:119,826,568...119,827,629 		JBrowse link
G Ccr9 C-C motif chemokine receptor 9 decreases expression ISO Cyclophosphamide results in decreased expression of CCR9 mRNA CTD PMID:21041162 NCBI chr 8:123,396,157...123,410,199
Ensembl chr 8:123,395,813...123,413,969 		JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 decreases expression EXP Cyclophosphamide results in decreased expression of CCT3 mRNA CTD PMID:11906922 NCBI chr 2:173,765,792...173,790,353
Ensembl chr 2:173,765,698...173,790,757 		JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 decreases expression EXP Cyclophosphamide results in decreased expression of CCT5 mRNA CTD PMID:11906922 NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930 		JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 decreases expression EXP Cyclophosphamide results in decreased expression of CCT7 mRNA CTD PMID:11906922 NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580 		JBrowse link
G Cd14 CD14 molecule increases expression ISO Cyclophosphamide results in increased expression of CD14 mRNA CTD PMID:15331540 PMID:21041162 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd151 CD151 molecule (Raph blood group) increases expression ISO Cyclophosphamide results in increased expression of CD151 mRNA CTD PMID:21041162 NCBI chr 1:196,564,744...196,568,753
Ensembl chr 1:196,565,181...196,568,753 		JBrowse link
G Cd2 Cd2 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD2 mRNA CTD PMID:21041162 NCBI chr 2:188,710,895...188,724,044
Ensembl chr 2:188,710,900...188,724,026 		JBrowse link
G Cd27 CD27 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD27 mRNA CTD PMID:21041162 NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592 		JBrowse link
G Cd28 Cd28 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD28 mRNA CTD PMID:21041162 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd38 CD38 molecule increases expression ISO Cyclophosphamide results in increased expression of CD38 mRNA CTD PMID:21041162 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cd3d CD3d molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD3D mRNA CTD PMID:21041162 NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809 		JBrowse link
G Cd3e CD3e molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD3E mRNA CTD PMID:21041162 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022 		JBrowse link
G Cd3g CD3g molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD3G mRNA CTD PMID:21041162 NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147 		JBrowse link
G Cd4 Cd4 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD4 mRNA CTD PMID:21041162 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Cd40 CD40 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD40 mRNA CTD PMID:21041162 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd5 Cd5 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD5 mRNA CTD PMID:21041162 NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313 		JBrowse link
G Cd6 Cd6 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD6 mRNA CTD PMID:21041162 NCBI chr 1:207,442,873...207,481,703
Ensembl chr 1:207,442,877...207,481,634 		JBrowse link
G Cd69 Cd69 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD69 mRNA
Cyclophosphamide metabolite results in decreased expression of CD69 mRNA		 CTD PMID:21041162 PMID:24356939 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Cd74 CD74 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD74 mRNA CTD PMID:15331540 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cd79b CD79b molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD79B mRNA CTD PMID:15331540 NCBI chr10:91,239,354...91,242,500
Ensembl chr10:91,239,356...91,242,625 		JBrowse link
G Cd83 CD83 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD83 mRNA CTD PMID:15331540 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083 		JBrowse link
G Cd84 CD84 molecule increases expression ISO Cyclophosphamide metabolite results in increased expression of CD84 mRNA CTD PMID:24356939 NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076 		JBrowse link
G Cd8a CD8a molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD8A mRNA CTD PMID:21041162 NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040 		JBrowse link
G Cd8b CD8b molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD8B1 mRNA CTD PMID:21041162 NCBI chr 4:103,312,596...103,328,523
Ensembl chr 4:103,312,578...103,328,553 		JBrowse link
G Cdc20 cell division cycle 20 increases expression EXP Cyclophosphamide results in increased expression of CDC20 mRNA CTD PMID:11599041 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Cdh1 cadherin 1 affects expression EXP Cyclophosphamide affects the expression of CDH1 mRNA CTD PMID:10859244 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 affects expression EXP Cyclophosphamide affects the expression of CDH2 mRNA CTD PMID:10859244 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdh3 cadherin 3 affects expression EXP Cyclophosphamide affects the expression of CDH3 mRNA CTD PMID:10859244 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Cyclophosphamide results in decreased expression of CDK2 mRNA CTD PMID:21041162 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Cyclophosphamide results in increased expression of CDKN1A mRNA CTD PMID:15331540 PMID:21527772 PMID:29445054 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of CDKN1B mRNA CTD PMID:16322899 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO Cyclophosphamide results in increased expression of CDKN1C mRNA CTD PMID:21041162 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D decreases expression ISO Cyclophosphamide results in decreased expression of CDKN2D mRNA CTD PMID:21041162 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Cyclophosphamide metabolite results in decreased expression of CEBPB mRNA CTD PMID:24356939 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cel carboxyl ester lipase increases expression ISO Cyclophosphamide results in increased expression of CEL mRNA CTD PMID:21527772 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035 		JBrowse link
G Cfb complement factor B increases expression ISO Cyclophosphamide results in increased expression of CFB mRNA CTD PMID:21041162 NCBI chr20:3,970,643...3,976,510 JBrowse link
G Cfi complement factor I affects response to substance ISO CFI protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of CHAC1 mRNA; Cyclophosphamide results in decreased expression of CHAC1 mRNA CTD PMID:23824090 PMID:24356939 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526 		JBrowse link
G Champ1 chromosome alignment maintaining phosphoprotein 1 increases expression EXP Cyclophosphamide results in increased expression of CHAMP1 mRNA CTD PMID:27281708 NCBI chr16:75,733,958...75,744,977
Ensembl chr16:75,733,805...75,744,984 		JBrowse link
G Chd5 chromodomain helicase DNA binding protein 5 decreases expression EXP Cyclophosphamide results in decreased expression of CHD5 mRNA CTD PMID:27281708 NCBI chr 5:162,848,273...162,898,997
Ensembl chr 5:162,848,394...162,896,291 		JBrowse link
G Chga chromogranin A decreases expression ISO Cyclophosphamide results in decreased expression of CHGA mRNA CTD PMID:15331540 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 increases expression EXP Cyclophosphamide results in increased expression of CHRM5 protein CTD PMID:16125470 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 affects expression
decreases expression		 EXP Cyclophosphamide affects the expression of CITED2 mRNA
Cyclophosphamide results in decreased expression of CITED2 mRNA		 CTD PMID:18246545 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Cldn1 claudin 1 multiple interactions
decreases expression		 ISO Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN1 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN1 protein] CTD PMID:32151603 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Cldn4 claudin 4 multiple interactions
decreases expression		 EXP Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN4 protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN4 protein] CTD PMID:25451569 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Clic4 chloride intracellular channel 4 increases expression ISO Cyclophosphamide results in increased expression of CLIC4 mRNA CTD PMID:15331540 NCBI chr 5:147,456,819...147,513,278
Ensembl chr 5:147,453,712...147,513,452 		JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 decreases expression EXP Cyclophosphamide results in decreased expression of CLIP1 mRNA CTD PMID:27281708 NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884 		JBrowse link
G Coch cochlin affects response to substance ISO COCH protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109 		JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Cyclophosphamide results in increased expression of COMT mRNA CTD PMID:21041162 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 decreases expression ISO Cyclophosphamide results in decreased expression of COX7A2 mRNA CTD PMID:17403535 NCBI chr 8:80,716,824...80,720,922 JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 increases expression ISO Cyclophosphamide results in increased expression of CRABP2 mRNA CTD PMID:21527772 NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression ISO Cyclophosphamide results in increased expression of CREB1 protein modified form CTD PMID:18299998 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crem cAMP responsive element modulator decreases expression
multiple interactions		 EXP Cyclophosphamide results in decreased expression of CREM mRNA; Cyclophosphamide results in decreased expression of CREM protein
Drugs, Chinese Herbal inhibits the reaction [Cyclophosphamide results in decreased expression of CREM mRNA]; Drugs, Chinese Herbal inhibits the reaction [Cyclophosphamide results in decreased expression of CREM protein]		 CTD PMID:17624719 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Crh corticotropin releasing hormone increases expression EXP
ISO		 Cyclophosphamide results in increased expression of CRH mRNA; Cyclophosphamide results in increased expression of CRH protein CTD PMID:15276878 PMID:16614059 PMID:17335920 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 increases expression EXP Cyclophosphamide results in increased expression of CRHR2 protein CTD PMID:16614059 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO [Cyclophosphamide co-treated with Sizofiran] results in increased expression of CSF1 mRNA CTD PMID:10052129 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csf2 colony stimulating factor 2 affects activity
increases expression		 ISO
EXP		 CSF2 protein affects the activity of Cyclophosphamide
Cyclophosphamide results in increased expression of CSF2 protein		 CTD PMID:8349185 PMID:18848347 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csk C-terminal Src kinase decreases expression ISO Cyclophosphamide results in decreased expression of CSK mRNA CTD PMID:21041162 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Cst7 cystatin F decreases expression ISO Cyclophosphamide results in decreased expression of CST7 mRNA CTD PMID:17403535 NCBI chr 3:139,396,830...139,405,557
Ensembl chr 3:139,396,850...139,405,557 		JBrowse link
G Csta cystatin A decreases expression ISO Cyclophosphamide metabolite results in decreased expression of CSTA mRNA CTD PMID:24356939 NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488 		JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO Cyclophosphamide results in increased expression of CTH protein CTD PMID:29129814 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of CTNNBIP1 mRNA CTD PMID:16322899 NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939 		JBrowse link
G Ctnnd2 catenin delta 2 multiple interactions ISO CTNND2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 2:81,168,976...82,016,495
Ensembl chr 2:81,167,117...82,015,764 		JBrowse link
G Ctsd cathepsin D multiple interactions
increases activity		 ISO
EXP		 [Cyclophosphamide co-treated with Mecamylamine] results in increased expression of CTSD mRNA
Cyclophosphamide results in increased activity of CTSD protein
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of CTSD protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in increased activity of CTSD protein]		 CTD PMID:18433785 PMID:25451569 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Ctsh cathepsin H increases expression ISO Cyclophosphamide results in increased expression of CTSH mRNA CTD PMID:17403535 NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824 		JBrowse link
G Ctsl cathepsin L increases expression
decreases expression
multiple interactions		 ISO Cyclophosphamide results in increased expression of CTSL mRNA
Cyclophosphamide results in decreased expression of CTSL mRNA
5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline inhibits the reaction [Cyclophosphamide results in decreased expression of CTSL mRNA]		 CTD PMID:17403535 PMID:30760223 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression EXP Cyclophosphamide results in increased expression of CX3CL1 protein CTD PMID:16651033 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 increases expression EXP Cyclophosphamide results in increased expression of CX3CR1 protein CTD PMID:16651033 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Cyclophosphamide results in increased expression of CXCL1 protein CTD PMID:18848347 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 affects expression
increases expression
increases response to substance		 ISO Cyclophosphamide affects the expression of CXCL10 mRNA
Cyclophosphamide results in increased expression of CXCL10 protein
CXCL10 protein results in increased susceptibility to Cyclophosphamide		 CTD PMID:18957084 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO Cyclophosphamide results in increased expression of CXCL11 protein CTD PMID:18957084 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 affects expression
increases expression		 ISO
EXP		 Cyclophosphamide affects the expression of CXCL12 mRNA
Cyclophosphamide results in increased expression of CXCL12 mRNA; Cyclophosphamide results in increased expression of CXCL12 protein		 CTD PMID:12624490 PMID:16337237 PMID:19066630 PMID:20032115 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
affects expression
multiple interactions		 ISO Cyclophosphamide results in increased expression of CXCL1 mRNA; Cyclophosphamide results in increased expression of CXCL1 protein
Cyclophosphamide affects the expression of CXCL3 mRNA
VIP protein inhibits the reaction [Cyclophosphamide results in increased expression of CXCL1 protein]		 CTD PMID:15331540 PMID:18483878 PMID:18957084 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO Cyclophosphamide results in increased expression of CXCL5 mRNA CTD PMID:15331540 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 affects expression
decreases expression
increases expression		 ISO Cyclophosphamide affects the expression of CXCL9 mRNA
Cyclophosphamide results in decreased expression of CXCL9 protein
Cyclophosphamide results in increased expression of CXCL9 mRNA; Cyclophosphamide results in increased expression of CXCL9 protein		 CTD PMID:15331540 PMID:18957084 PMID:21041162 PMID:21880982 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions
decreases expression
increases expression
affects localization		 EXP
ISO		 Cyclophosphamide promotes the reaction [MIF protein binds to CXCR4 protein]
Cyclophosphamide results in decreased expression of CXCR4 mRNA
Cyclophosphamide results in increased expression of CXCR4 mRNA; Cyclophosphamide results in increased expression of CXCR4 protein
Cyclophosphamide affects the localization of CXCR4 protein		 CTD PMID:19066630 PMID:20032115 PMID:21041162 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cxcr6 C-X-C motif chemokine receptor 6 increases expression ISO Cyclophosphamide results in increased expression of CXCR6 mRNA CTD PMID:21041162 NCBI chr 8:123,434,417...123,439,568
Ensembl chr 8:123,416,325...123,439,526 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Cyclophosphamide results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Cyclophosphamide results in decreased activity of CYP1A2 protein CTD PMID:18420780 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO Cyclophosphamide results in decreased expression of CYP1B1 mRNA CTD PMID:12167460 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
increases response to substance
affects metabolic processing
increases activity
increases hydroxylation
increases metabolic processing		 EXP
ISO		 Cyclophosphamide results in increased expression of and results in increased activity of CYP2B1 protein; Metyrapone inhibits the reaction [CYP2B1 results in increased susceptibility to Cyclophosphamide]
Cyclophosphamide results in increased expression of CYP2B10 mRNA
CYP2B1 protein results in increased susceptibility to Cyclophosphamide; CYP2B1 results in increased susceptibility to Cyclophosphamide
CYP2B1 protein affects the metabolism of Cyclophosphamide
CYP2B1 results in increased activity of Cyclophosphamide
CYP2B1 protein mutant form results in increased hydroxylation of Cyclophosphamide; CYP2B1 protein results in increased hydroxylation of Cyclophosphamide
Cyclophosphamide results in increased expression of CYP2B1 mRNA; Cyclophosphamide results in increased expression of CYP2B1 protein
CYP2B1 protein results in increased metabolism of Cyclophosphamide; CYP2B1 results in increased metabolism of Cyclophosphamide		 CTD PMID:2272335 PMID:7834628 PMID:8640822 PMID:9592392 PMID:10415877 More... NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Cyclophosphamide results in increased expression of CYP2B2 mRNA; Cyclophosphamide results in increased expression of CYP2B2 protein CTD PMID:16019949 PMID:17634551 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases metabolic processing
increases activity
increases response to substance
increases hydroxylation
affects hydroxylation		 ISO
EXP		 [Cyclophosphamide results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; [Doxorubicin co-treated with Cyclophosphamide] affects the expression of CYP2B6 mRNA; Cyclophosphamide results in decreased expression of and results in decreased activity of CYP2B6 protein; CYP2B6 protein polymorphism affects the activity of and affects the susceptibility to Cyclophosphamide; CYP2B6 protein results in increased metabolism of and results in increased susceptibility to Cyclophosphamide; POR promotes the reaction [CYP2B6 results in increased susceptibility to Cyclophosphamide]; POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to Cyclophosphamide]
CYP2B6 protein results in increased metabolism of Cyclophosphamide
CYP2B6 protein results in increased activity of Cyclophosphamide
CYP2B6 protein results in increased susceptibility to Cyclophosphamide; CYP2B6 results in increased susceptibility to Cyclophosphamide
CYP2B6 protein results in increased hydroxylation of Cyclophosphamide
CYP2B6 intron polymorphism affects the hydroxylation of Cyclophosphamide; CYP2B6 promoter polymorphism affects the hydroxylation of Cyclophosphamide		 CTD PMID:9766669 PMID:10919648 PMID:11389073 PMID:11723234 PMID:12498089 More... NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression
multiple interactions
increases metabolic processing
increases response to substance
increases activity		 EXP
ISO		 Cyclophosphamide results in increased expression of CYP2C11 mRNA
[GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased susceptibility to Cyclophosphamide]
CYP2C9 protein results in increased metabolism of Cyclophosphamide
CYP2C9 results in increased activity of Cyclophosphamide
CYP2C11 results in increased metabolism of Cyclophosphamide		 CTD PMID:9241661 PMID:10991840 PMID:11377097 PMID:16019949 PMID:20566340 More... NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions
increases response to substance
increases activity		 ISO POR promotes the reaction [CYP2C18 results in increased susceptibility to Cyclophosphamide]
CYP2C18 results in increased activity of Cyclophosphamide		 CTD PMID:9241661 PMID:9766669 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing
increases response to substance
increases hydroxylation
increases activity
multiple interactions
decreases metabolic processing		 EXP
ISO		 CYP2C6V1 results in increased metabolism of Cyclophosphamide
CYP2C19 protein results in increased susceptibility to Cyclophosphamide
CYP2C19 protein results in increased hydroxylation of Cyclophosphamide
CYP2C19 results in increased activity of Cyclophosphamide
CYP2C19 protein results in increased metabolism of Cyclophosphamide
[CYP2C19 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of 4-hydroxycyclophosphamide; [CYP2C19 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of Acrolein; CYP2C19 protein polymorphism affects the activity of and affects the susceptibility to Cyclophosphamide
CYP2C19 gene polymorphism results in decreased metabolism of Cyclophosphamide		 CTD PMID:9241661 PMID:15248218 PMID:16116487 PMID:20566340 PMID:30500380 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases activity
increases expression		 ISO CYP2C8 results in increased activity of Cyclophosphamide
Cyclophosphamide results in increased expression of CYP2C29 mRNA		 CTD PMID:9241661 PMID:24819615
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of Cyclophosphamide CTD PMID:11377097 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing EXP CYP2E1 results in increased metabolism of Cyclophosphamide CTD PMID:20566340 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
increases response to substance
increases hydroxylation
affects metabolic processing
affects response to substance
increases metabolic processing
multiple interactions		 EXP
ISO		 Cyclophosphamide results in increased expression of CYP3A2 mRNA; Cyclophosphamide results in increased expression of CYP3A2 protein
Cyclophosphamide results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased susceptibility to Cyclophosphamide
CYP3A4 protein results in increased hydroxylation of Cyclophosphamide
CYP3A4 protein affects the metabolism of Cyclophosphamide
CYP3A4 gene polymorphism affects the susceptibility to Cyclophosphamide
CYP3A4 protein results in increased metabolism of Cyclophosphamide
[Cyclophosphamide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [CYP3A4 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of 4-hydroxycyclophosphamide; [CYP3A4 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of Acrolein; CYP3A4 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin]; CYP3A4 protein results in increased metabolism of and results in increased susceptibility to Cyclophosphamide		 CTD PMID:11377097 PMID:16019949 PMID:16087946 PMID:17041008 PMID:18839173 More... NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects expression
decreases expression		 EXP Cyclophosphamide affects the expression of CYP3A23-3A1 mRNA
Cyclophosphamide results in decreased expression of CYP3A23-3A1 mRNA		 CTD PMID:18246545 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing
increases expression
multiple interactions
affects response to substance		 ISO CYP3A5 protein affects the metabolism of Cyclophosphamide
Cyclophosphamide results in increased expression of CYP3A13 mRNA
CYP3A5 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin]
CYP3A5 gene polymorphism affects the susceptibility to Cyclophosphamide		 CTD PMID:16087946 PMID:24819615 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Dcn decorin multiple interactions ISO DCN protein inhibits the reaction [TGFB1 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Cisplatin co-treated with Melphalan co-treated with Thiotepa]] CTD PMID:9509296 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270 		JBrowse link
G Ddb1 damage-specific DNA binding protein 1 increases expression EXP Cyclophosphamide results in increased expression of DDB1 mRNA CTD PMID:11056294 NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression
increases expression
multiple interactions
decreases expression		 EXP
ISO		 Cyclophosphamide affects the expression of DDIT3 mRNA
Cyclophosphamide results in increased expression of DDIT3 mRNA; Cyclophosphamide results in increased expression of DDIT3 protein
sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 mRNA]; sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 protein]
Cyclophosphamide metabolite results in decreased expression of DDIT3 mRNA		 CTD PMID:18246545 PMID:24356939 PMID:32197949 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 affects response to substance ISO DDIT4 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Deaf1 DEAF1 transcription factor decreases expression EXP Cyclophosphamide results in decreased expression of DEAF1 mRNA CTD PMID:27281708 NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541 		JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein increases expression ISO Cyclophosphamide results in increased expression of DLC1 mRNA CTD PMID:17403535 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 affects expression
increases expression		 EXP
ISO		 Cyclophosphamide affects the expression of DNAJB1 mRNA
Cyclophosphamide metabolite results in increased expression of DNAJB1 mRNA		 CTD PMID:18246545 PMID:24356939 NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Cyclophosphamide metabolite results in increased expression of DNAJB4 mRNA CTD PMID:24356939 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089 		JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 increases expression ISO Cyclophosphamide results in increased expression of DNAJB6 protein CTD PMID:17475930 NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659 		JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions
increases expression
decreases methylation		 ISO Cyclophosphamide promotes the reaction [KDM1A protein results in decreased methylation of and results in decreased degradation of DNMT1 protein]
Cyclophosphamide results in increased expression of DNMT1 protein
Cyclophosphamide results in decreased methylation of DNMT1 protein		 CTD PMID:22007908 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dntt DNA nucleotidylexotransferase decreases expression ISO Cyclophosphamide results in decreased expression of DNTT mRNA CTD PMID:21041162 NCBI chr 1:239,856,391...239,888,283
Ensembl chr 1:239,856,391...239,888,282 		JBrowse link
G Dpf3 double PHD fingers 3 decreases expression EXP Cyclophosphamide results in decreased expression of DPF3 mRNA CTD PMID:27281708 NCBI chr 6:102,841,403...103,125,558
Ensembl chr 6:102,846,029...103,125,493 		JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 increases expression ISO Cyclophosphamide results in increased expression of DPYSL4 mRNA CTD PMID:21527772 NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914 		JBrowse link
G Drd1 dopamine receptor D1 affects binding ISO Cyclophosphamide binds to DRD1 protein CTD PMID:11180191 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 affects binding ISO Cyclophosphamide binds to DRD2 protein CTD PMID:11180191 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Dusp10 dual specificity phosphatase 10 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of DUSP10 mRNA CTD PMID:24356939 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression ISO Cyclophosphamide results in decreased expression of DUSP2 mRNA CTD PMID:21041162 NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499 		JBrowse link
G Dzip1 DAZ interacting zinc finger protein 1 increases expression ISO Cyclophosphamide results in increased expression of DZIP1 mRNA CTD PMID:17403535 NCBI chr15:95,956,329...96,009,994
Ensembl chr15:95,956,398...96,010,066 		JBrowse link
G E2f3 E2F transcription factor 3 multiple interactions ISO E2F3 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253 		JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO Cyclophosphamide results in increased expression of EDA2R mRNA CTD PMID:21527772 NCBI chr  X:62,224,763...62,269,344
Ensembl chr  X:62,228,229...62,269,268 		JBrowse link
G Edn1 endothelin 1 increases expression ISO Cyclophosphamide results in increased expression of EDN1 protein CTD PMID:17562616 PMID:18548196 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednrb endothelin receptor type B increases expression ISO Cyclophosphamide results in increased expression of EDNRB mRNA CTD PMID:20849824 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression EXP Cyclophosphamide results in decreased expression of EEF2 mRNA CTD PMID:18246545 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR protein affects the susceptibility to [Cyclophosphamide co-treated with Doxorubicin co-treated with Fluorouracil] CTD PMID:15981280 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
decreases expression		 ISO
EXP		 Cyclophosphamide results in increased expression of EGR1 mRNA
3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein
Cyclophosphamide results in increased expression of EGR1 protein
Cyclophosphamide results in decreased expression of EGR1 mRNA		 CTD PMID:7498375 PMID:9776515 PMID:21041162 PMID:21527772 PMID:29129814 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Egr2 early growth response 2 decreases expression ISO Cyclophosphamide results in decreased expression of EGR2 mRNA CTD PMID:21041162 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562 		JBrowse link
G Egr4 early growth response 4 decreases expression EXP Cyclophosphamide results in decreased expression of EGR4 mRNA CTD PMID:27281708 NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328 		JBrowse link
G Eif1ax eukaryotic translation initiation factor 1A, X-linked multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of EIF1AX mRNA CTD PMID:16322899 NCBI chr  X:35,498,698...35,513,402
Ensembl chr  X:35,498,517...35,513,335 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
multiple interactions		 EXP Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein
sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein]		 CTD PMID:32197949 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of EIF4EBP1 mRNA CTD PMID:16322899 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 affects response to substance ISO ELOVL2 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr17:23,544,520...23,584,855
Ensembl chr17:23,544,568...23,584,848 		JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Cyclophosphamide results in increased expression of EMP1 mRNA CTD PMID:21527772 NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904 		JBrowse link
G Emp3 epithelial membrane protein 3 increases expression ISO Cyclophosphamide results in increased expression of EMP3 mRNA CTD PMID:21527772 NCBI chr 1:96,388,651...96,391,946
Ensembl chr 1:96,388,652...96,391,988 		JBrowse link
G Epb41l2 erythrocyte membrane protein band 4.1-like 2 decreases expression ISO Cyclophosphamide results in decreased expression of EPB41L2 mRNA CTD PMID:17403535 NCBI chr 1:19,863,010...20,037,795
Ensembl chr 1:19,863,009...20,037,721 		JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression
increases expression		 EXP Cyclophosphamide affects the expression of EPHX1 mRNA
Cyclophosphamide results in increased expression of EPHX1 mRNA		 CTD PMID:18246545 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Epo erythropoietin multiple interactions
increases response to substance
decreases expression		 EXP angelicae sinensis extract inhibits the reaction [Cyclophosphamide results in decreased expression of EPO mRNA]; Astragali compound inhibits the reaction [Cyclophosphamide results in decreased expression of EPO mRNA]
EPO protein results in increased susceptibility to Cyclophosphamide		 CTD PMID:11245434 PMID:19627214 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Erap1 endoplasmic reticulum aminopeptidase 1 increases expression EXP Cyclophosphamide results in increased expression of ERAP1 mRNA CTD PMID:27281708 NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO ERBB2 affects the susceptibility to [Doxorubicin co-treated with Cyclophosphamide co-treated with docetaxel]; ERBB2 protein affects the susceptibility to [Cyclophosphamide co-treated with Doxorubicin co-treated with docetaxel]; ERBB2 protein affects the susceptibility to [Cyclophosphamide co-treated with pirarubicin co-treated with Fluorouracil]; ERBB2 protein affects the susceptibility to [Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]; ERBB2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; ERBB2 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Thiotepa co-treated with Carboplatin] CTD PMID:9816327 PMID:15834928 PMID:15940066 PMID:16446318 PMID:16682728 More... NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO ERBB4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit affects expression EXP Cyclophosphamide affects the expression of ERCC1 mRNA CTD PMID:11906922 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit affects expression
increases expression
multiple interactions		 EXP
ISO		 Cyclophosphamide affects the expression of ERCC2 mRNA
Cyclophosphamide results in increased expression of ERCC2 mRNA
5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline inhibits the reaction [Cyclophosphamide results in increased expression of ERCC2 mRNA]		 CTD PMID:11906922 PMID:30760223 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102 		JBrowse link
G Erg ETS transcription factor ERG increases expression ISO Cyclophosphamide results in increased expression of ERG mRNA CTD PMID:17403535 NCBI chr11:34,678,614...34,900,951
Ensembl chr11:34,678,618...34,845,871 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases phosphorylation
multiple interactions		 EXP Cyclophosphamide results in increased phosphorylation of ERN1 protein
sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in increased phosphorylation of ERN1 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of ERN1 protein]		 CTD PMID:32197949 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] results in increased expression of ESR1 mRNA CTD PMID:16322899 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] results in increased expression of ESR2 mRNA CTD PMID:16322899 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Esrra estrogen related receptor, alpha decreases expression
increases expression		 EXP Cyclophosphamide results in decreased expression of ESRRA mRNA
Cyclophosphamide results in increased expression of ESRRA mRNA		 CTD PMID:27281708 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Evi2a ecotropic viral integration site 2A decreases expression ISO Cyclophosphamide metabolite results in decreased expression of EVI2A mRNA CTD PMID:24356939 NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 increases expression EXP Cyclophosphamide results in increased expression of F2RL1 protein CTD PMID:15643279 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 increases expression EXP Cyclophosphamide results in increased expression of F2RL2 protein CTD PMID:15643279 NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098 		JBrowse link
G F2rl3 F2R like thrombin or trypsin receptor 3 increases expression EXP Cyclophosphamide results in increased expression of F2RL3 protein CTD PMID:15643279 NCBI chr16:17,117,441...17,119,434
Ensembl chr16:17,117,441...17,119,472 		JBrowse link
G F3 coagulation factor III, tissue factor decreases expression ISO Cyclophosphamide results in decreased expression of F3 mRNA CTD PMID:17403535 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fam107b family with sequence similarity 107, member B decreases expression ISO Cyclophosphamide metabolite results in decreased expression of FAM107B mRNA CTD PMID:24356939 NCBI chr17:74,478,608...74,685,027
Ensembl chr17:74,478,608...74,684,989 		JBrowse link
G Fam234b family with sequence similarity 234, member B multiple interactions ISO FAM234B mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 4:168,048,313...168,124,017
Ensembl chr 4:168,048,396...168,097,338 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
decreases expression
increases expression		 ISO
EXP		 [Cyclophosphamide co-treated with cacalol] results in decreased expression of FAS protein; [Cyclophosphamide co-treated with NAc-Sar-Gly-Val-(d-allo-Ile)-Thr-Nva-Ile-Arg-ProNEt] results in increased expression of FAS
Plant Extracts inhibits the reaction [Cyclophosphamide results in increased expression of FAS mRNA]
Cyclophosphamide metabolite results in decreased expression of FAS mRNA
Cyclophosphamide results in increased expression of FAS mRNA; Cyclophosphamide results in increased expression of FAS protein		 CTD PMID:10393266 PMID:16166447 PMID:20665104 PMID:24356939 PMID:25446862 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [Cyclophosphamide co-treated with NAc-Sar-Gly-Val-(d-allo-Ile)-Thr-Nva-Ile-Arg-ProNEt] results in increased expression of FASLG CTD PMID:16166447 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fau FAU, ubiquitin like and ribosomal protein S30 fusion increases expression EXP Cyclophosphamide results in increased expression of FAU mRNA CTD PMID:11599041 NCBI chr 1:203,350,226...203,351,741
Ensembl chr 1:203,350,189...203,351,742 		JBrowse link
G Fbxo40 F-box protein 40 increases expression EXP Cyclophosphamide results in increased expression of FBXO40 mRNA CTD PMID:27281708 NCBI chr11:63,794,452...63,812,697
Ensembl chr11:63,794,624...63,812,697 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 increases expression ISO Cyclophosphamide results in increased expression of FBXW7 mRNA CTD PMID:29445054 NCBI chr 2:170,150,552...170,310,698
Ensembl chr 2:170,149,694...170,309,941 		JBrowse link
G Fcer1g Fc epsilon receptor Ig increases expression ISO Cyclophosphamide results in increased expression of FCER1G mRNA CTD PMID:21041162 NCBI chr13:83,649,447...83,654,215
Ensembl chr13:83,649,449...83,671,443 		JBrowse link
G Fcgr2a Fc gamma receptor IIa increases expression ISO Cyclophosphamide results in increased expression of FCGR3 mRNA CTD PMID:21041162 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967 		JBrowse link
G Fcgrt Fc gamma receptor and transporter increases expression ISO Cyclophosphamide results in increased expression of FCGRT mRNA CTD PMID:21041162 NCBI chr 1:95,574,436...95,584,171
Ensembl chr 1:95,567,175...95,584,084 		JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Cyclophosphamide results in increased expression of FHL1 mRNA CTD PMID:23558518 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B affects response to substance ISO FKBP1B protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653 		JBrowse link
G Fkbpl FKBP prolyl isomerase like increases expression ISO Cyclophosphamide results in increased expression of FKBPL mRNA CTD PMID:14503796 NCBI chr20:4,099,845...4,101,315
Ensembl chr20:4,099,806...4,101,368 		JBrowse link
G Flnc filamin C increases expression ISO Cyclophosphamide results in increased expression of FLNC mRNA CTD PMID:21527772 NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844 		JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand affects expression ISO Cyclophosphamide affects the expression of FLT3L mRNA CTD PMID:12624490 NCBI chr 1:95,615,056...95,620,463 JBrowse link
G Fndc3b fibronectin type III domain containing 3B affects response to substance ISO FNDC3B protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO
EXP		 Capsaicin inhibits the reaction [Cyclophosphamide results in increased expression of FOS mRNA]
Cyclophosphamide results in increased expression of FOS protein
alfuzosin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein]; Capsaicin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein]; resiniferatoxin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein]		 CTD PMID:7498375 PMID:8801120 PMID:8808730 PMID:9776515 PMID:10749792 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxp3 forkhead box P3 decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased expression of FOXP3 mRNA; Cyclophosphamide results in decreased expression of FOXP3 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of FOXP3 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of FOXP3 protein]		 CTD PMID:15591121 PMID:32151603 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Foxp4 forkhead box P4 decreases expression EXP Cyclophosphamide results in decreased expression of FOXP4 mRNA CTD PMID:27281708 NCBI chr 9:13,058,506...13,115,406
Ensembl chr 9:13,058,476...13,114,879 		JBrowse link
G Fpr2 formyl peptide receptor 2 increases expression ISO Cyclophosphamide results in increased expression of FPR2 mRNA CTD PMID:15331540 NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 increases expression ISO Cyclophosphamide results in increased expression of FSCN1 mRNA CTD PMID:17403535 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211 		JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression
multiple interactions
decreases secretion		 ISO
EXP		 Cyclophosphamide results in increased expression of FSHB protein
sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in decreased secretion of FSHB protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of FSHB protein]		 CTD PMID:6788612 PMID:25446862 PMID:32197949 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions
decreases expression		 ISO coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of FSHR mRNA] CTD PMID:31557371 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase increases expression ISO Cyclophosphamide results in increased expression of FYN mRNA CTD PMID:17403535 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 decreases expression ISO Cyclophosphamide results in decreased expression of G3BP1 mRNA CTD PMID:21041162 NCBI chr10:39,586,864...39,620,268
Ensembl chr10:39,586,864...39,620,268 		JBrowse link
G G6pc2 glucose-6-phosphatase catalytic subunit 2 decreases expression ISO Cyclophosphamide results in decreased expression of G6PC2 mRNA CTD PMID:15331540 NCBI chr 3:53,999,821...54,005,539 JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression
affects expression		 EXP
ISO		 Cyclophosphamide results in increased expression of GADD45A mRNA
Cyclophosphamide affects the expression of GADD45A mRNA		 CTD PMID:18246545 PMID:29445054 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gal galanin and GMAP prepropeptide affects expression
increases expression		 EXP
ISO		 Cyclophosphamide affects the expression of GAL mRNA; Cyclophosphamide affects the expression of GAL protein
Cyclophosphamide results in increased expression of GAL mRNA		 CTD PMID:16491427 PMID:17335920 PMID:18563302 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Galc galactosylceramidase affects response to substance ISO GALC protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 6:117,452,888...117,522,281
Ensembl chr 6:117,452,895...117,515,830 		JBrowse link
G Gamt guanidinoacetate N-methyltransferase multiple interactions ISO GAMT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 7:9,448,590...9,451,778
Ensembl chr 7:9,448,628...9,451,778 		JBrowse link
G Gap43 growth associated protein 43 increases expression EXP Cyclophosphamide results in increased expression of GAP43 protein CTD PMID:9486479 PMID:10536274 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gas2 growth arrest-specific 2 increases expression ISO Cyclophosphamide results in increased expression of GAS2 protein CTD PMID:17475930 NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619 		JBrowse link
G Gata3 GATA binding protein 3 decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased expression of GATA3 mRNA; Cyclophosphamide results in decreased expression of GATA3 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of GATA3 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of GATA3 protein]		 CTD PMID:21041162 PMID:32151603 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gbp1 guanylate binding protein 1 increases expression ISO Cyclophosphamide results in increased expression of GBP1 mRNA CTD PMID:21621594 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,517,398...231,529,600 		JBrowse link
G Gbp4 guanylate binding protein 4 increases expression ISO Cyclophosphamide results in increased expression of GBP3 mRNA CTD PMID:15331540 NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
decreases expression		 ISO Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of GCLC protein]
Cyclophosphamide results in decreased expression of GCLC mRNA; Cyclophosphamide results in decreased expression of GCLC protein		 CTD PMID:27633142 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression EXP Cyclophosphamide results in increased expression of GDNF mRNA CTD PMID:10683293 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression ISO Cyclophosphamide results in increased expression of GEM mRNA CTD PMID:21041162 NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor decreases expression ISO Cyclophosphamide results in decreased expression of GFI1 mRNA CTD PMID:21041162 NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 multiple interactions ISO GFRA1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 1:257,315,682...257,552,004 JBrowse link
G Gimap4 GTPase, IMAP family member 4 decreases expression EXP Cyclophosphamide results in decreased expression of GIMAP4 mRNA CTD PMID:27466211 NCBI chr 4:77,636,401...77,643,315
Ensembl chr 4:77,636,401...77,643,306 		JBrowse link
G Gja1 gap junction protein, alpha 1 affects expression EXP Cyclophosphamide affects the expression of GJA1 mRNA CTD PMID:10859244 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression ISO Cyclophosphamide results in decreased expression of GJB1 mRNA CTD PMID:21621594 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925 		JBrowse link
G Glis1 GLIS family zinc finger 1 decreases expression EXP Cyclophosphamide results in decreased expression of GLIS1 mRNA CTD PMID:27281708 NCBI chr 5:122,222,155...122,412,141
Ensembl chr 5:122,222,128...122,412,141 		JBrowse link
G Glod4 glyoxalase domain containing 4 decreases expression ISO Cyclophosphamide results in decreased expression of GLOD4 mRNA CTD PMID:20849824 NCBI chr10:61,077,535...61,095,876
Ensembl chr10:61,066,421...61,095,898 		JBrowse link
G Glrb glycine receptor, beta increases expression ISO Cyclophosphamide results in increased expression of GLRB mRNA CTD PMID:17403535 NCBI chr 2:166,134,624...166,207,509
Ensembl chr 2:166,134,626...166,207,489 		JBrowse link
G Gls glutaminase increases expression
affects response to substance		 ISO Cyclophosphamide results in increased expression of GLS mRNA
GLS protein affects the susceptibility to Cyclophosphamide		 CTD PMID:16217747 PMID:21527772 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900 		JBrowse link
G Gng12 G protein subunit gamma 12 increases expression ISO Cyclophosphamide results in increased expression of GNG12 mRNA CTD PMID:17403535 NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712 		JBrowse link
G Gpatch8 G patch domain containing 8 increases expression EXP Cyclophosphamide results in increased expression of GPATCH8 mRNA CTD PMID:27281708 NCBI chr10:87,432,020...87,512,595
Ensembl chr10:87,433,266...87,512,419 		JBrowse link
G Gpr137b G protein-coupled receptor 137B increases expression ISO Cyclophosphamide results in increased expression of GPR137B mRNA CTD PMID:21527772 NCBI chr17:86,003,630...86,041,841
Ensembl chr17:85,966,921...86,041,835 		JBrowse link
G Gpr18 G protein-coupled receptor 18 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of GPR18 mRNA CTD PMID:24356939 NCBI chr15:98,997,427...99,001,177
Ensembl chr15:98,997,259...99,001,470 		JBrowse link
G Gpr20 G protein-coupled receptor 20 increases expression ISO Cyclophosphamide results in increased expression of GPR20 mRNA CTD PMID:20849824 NCBI chr 7:105,601,761...105,611,959
Ensembl chr 7:105,602,368...105,603,430 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
affects activity
increases activity
multiple interactions		 EXP
ISO		 Cyclophosphamide results in increased expression of GPT protein
Cyclophosphamide affects the activity of GPT protein
Cyclophosphamide results in increased activity of GPT protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein]
naringin affects the reaction [Cyclophosphamide affects the activity of GPT protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein]; Vitamin E inhibits the reaction [Cyclophosphamide results in increased expression of GPT protein]		 CTD PMID:25753322 PMID:25779342 PMID:29753871 PMID:30506662 PMID:33992719 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of GPT2 mRNA CTD PMID:24356939 NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased expression of GPX1 mRNA
Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of GPX1 mRNA]		 CTD PMID:23542512 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO Cyclophosphamide results in increased expression of GPX3 mRNA CTD PMID:21041162 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression ISO Cyclophosphamide results in increased expression of GPX4 protein CTD PMID:17475930 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity		 ISO
EXP		 [[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione Disulfide; [Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein; Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of GSR protein]]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]
naringin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]		 CTD PMID:12114195 PMID:21772021 PMID:23542512 PMID:25446862 PMID:25753322 More... NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO GSTA1 protein affects the metabolism of [Cyclophosphamide metabolite co-treated with Glutathione] CTD PMID:12516103 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO [GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide]; GSTM1 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin] CTD PMID:16087946 PMID:28744217 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Cyclophosphamide results in decreased expression of GSTM2 mRNA CTD PMID:11906922 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases response to substance
affects response to substance
increases expression		 ISO
EXP		 GSTP1 gene SNP results in increased susceptibility to [Carmustine co-treated with Doxorubicin co-treated with Cyclophosphamide co-treated with Melphalan]
GSTP1 protein results in decreased susceptibility to Cyclophosphamide
GSTP1 protein affects the susceptibility to Cyclophosphamide
GSTP1 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; Mesna inhibits the reaction [GSTP1 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]]
Cyclophosphamide results in increased expression of GSTP1 mRNA; Cyclophosphamide results in increased expression of GSTP1 protein		 CTD PMID:10954901 PMID:12791655 PMID:16141653 PMID:16242832 PMID:19696094 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gtf2b general transcription factor IIB increases expression EXP Cyclophosphamide results in increased expression of GTF2B mRNA CTD PMID:27281708 NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651 		JBrowse link
G Gtf3c1 general transcription factor IIIC subunit 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of GTF3C1 mRNA CTD PMID:16322899 NCBI chr 1:180,203,995...180,270,201
Ensembl chr 1:180,203,995...180,270,201 		JBrowse link
G Gusb glucuronidase, beta decreases expression
increases activity
multiple interactions		 EXP Cyclophosphamide results in decreased expression of GUSB protein
Cyclophosphamide results in increased activity of GUSB protein
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of GUSB protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in increased activity of GUSB protein]		 CTD PMID:17686619 PMID:25451569 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Gzma granzyme A decreases expression ISO Cyclophosphamide results in decreased expression of GZMA mRNA CTD PMID:21041162 NCBI chr 2:44,740,638...44,752,471
Ensembl chr 2:44,740,569...44,752,493 		JBrowse link
G Gzmb granzyme B increases expression ISO Cyclophosphamide results in increased expression of GZMB mRNA CTD PMID:15331540 NCBI chr15:30,343,361...30,346,792 JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Cyclophosphamide results in increased phosphorylation of H2AX protein CTD PMID:32482060 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hcrt hypocretin neuropeptide precursor affects localization
decreases expression		 EXP Cyclophosphamide affects the localization of HCRT protein
Cyclophosphamide results in decreased expression of HCRT mRNA		 CTD PMID:17881193 PMID:19666069 NCBI chr10:85,689,992...85,691,206
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO Cyclophosphamide results in increased expression of HIF1A mRNA CTD PMID:15331540 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hinfp histone H4 transcription factor decreases expression EXP Cyclophosphamide results in decreased expression of HINFP mRNA CTD PMID:27281708 NCBI chr 8:44,634,333...44,644,288
Ensembl chr 8:44,634,333...44,641,000 		JBrowse link
G Hm13 histocompatibility minor 13 decreases expression ISO Cyclophosphamide results in decreased expression of H13 mRNA CTD PMID:15331540 NCBI chr 3:141,145,769...141,184,703
Ensembl chr 3:141,145,782...141,184,703 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Cyclophosphamide metabolite results in increased expression of HMGCS1 mRNA CTD PMID:24356939 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression
decreases expression
multiple interactions
increases expression		 EXP
ISO		 Cyclophosphamide affects the expression of HMOX1 mRNA
Cyclophosphamide results in decreased expression of HMOX1 protein
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of HMOX1 protein; Hemin inhibits the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]
Cyclophosphamide results in increased expression of HMOX1 mRNA; Cyclophosphamide results in increased expression of HMOX1 protein		 CTD PMID:11906922 PMID:17979934 PMID:18206168 PMID:18246545 PMID:19952508 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hmox2 heme oxygenase 2 decreases expression EXP Cyclophosphamide results in decreased expression of HMOX2 mRNA CTD PMID:11906922 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K increases expression ISO
EXP		 Cyclophosphamide results in increased expression of HNRNPK protein
Cyclophosphamide results in increased expression of HNRNPK mRNA		 CTD PMID:11599041 PMID:17475930 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Hoxa1 homeobox A1 affects response to substance ISO HOXA1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 4:81,255,814...81,258,504
Ensembl chr 4:81,255,883...81,258,504 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis ISO
EXP		 Cyclophosphamide results in increased mutagenesis of HPRT1 gene CTD PMID:17116724 PMID:23677247 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression EXP Cyclophosphamide results in decreased expression of HSP90AA1 mRNA CTD PMID:11906922 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression EXP Cyclophosphamide results in decreased expression of HSP90AB1 mRNA CTD PMID:11906922 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression
increases expression		 EXP Cyclophosphamide results in decreased expression of HSP90B1 mRNA
Cyclophosphamide results in increased expression of HSP90B1 mRNA		 CTD PMID:11599041 PMID:11906922 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A affects expression
increases expression		 EXP
ISO		 Cyclophosphamide affects the expression of HSPA1A mRNA
Cyclophosphamide results in increased expression of HSPA1A mRNA; Cyclophosphamide results in increased expression of HSPA1A protein		 CTD PMID:8917683 PMID:18246545
G Hspa1b heat shock protein family A (Hsp70) member 1B affects expression
increases expression
decreases expression		 EXP
ISO		 Cyclophosphamide affects the expression of HSPA1B mRNA
Cyclophosphamide metabolite results in increased expression of HSPA1B mRNA
Cyclophosphamide results in decreased expression of HSPA1B mRNA		 CTD PMID:16141653 PMID:18246545 PMID:24356939 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 affects response to substance
increases expression		 ISO
EXP		 HSPA2 protein affects the susceptibility to Cyclophosphamide
Cyclophosphamide results in increased expression of HSPA2 mRNA		 CTD PMID:11599041 PMID:16217747 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
increases expression		 EXP
ISO		 Cyclophosphamide results in decreased expression of HSPA5 mRNA
Cyclophosphamide metabolite results in increased expression of HSPA5 mRNA		 CTD PMID:11906922 PMID:24356939 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 affects response to substance ISO HSPA8 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 decreases expression EXP Cyclophosphamide results in decreased expression of HSPA9 mRNA CTD PMID:11906922 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression
increases expression		 EXP Cyclophosphamide results in decreased expression of HSPB1 mRNA
Cyclophosphamide results in increased expression of HSPB1 mRNA		 CTD PMID:11599041 PMID:11906922 PMID:18246545 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression EXP Cyclophosphamide results in decreased expression of HSPD1 mRNA CTD PMID:11906922 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 decreases expression EXP Cyclophosphamide results in decreased expression of HSPE1 mRNA CTD PMID:11906922 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO Cyclophosphamide metabolite results in increased expression of HSPH1 mRNA CTD PMID:24356939 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224 		JBrowse link
G Hyls1 HYLS1, centriolar and ciliogenesis associated decreases expression ISO Cyclophosphamide metabolite results in decreased expression of HYLS1 mRNA CTD PMID:24356939 NCBI chr 8:33,913,016...33,922,125
Ensembl chr 8:33,912,692...33,921,760 		JBrowse link
G Hyou1 hypoxia up-regulated 1 decreases expression EXP Cyclophosphamide results in decreased expression of HYOU1 mRNA CTD PMID:11906922 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186 		JBrowse link
G Ica1 islet cell autoantigen 1 affects response to substance ISO ICA1 protein affects the susceptibility to Cyclophosphamide CTD PMID:11751995 NCBI chr 4:36,656,475...36,804,705
Ensembl chr 4:36,656,475...36,804,298 		JBrowse link
G Icam1 intercellular adhesion molecule 1 affects response to substance ISO ICAM1 protein affects the susceptibility to Cyclophosphamide CTD PMID:11591119 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of ID2 mRNA CTD PMID:24356939 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO Cyclophosphamide metabolite results in increased expression of IDI1 mRNA CTD PMID:24356939 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Ier3 immediate early response 3 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of IER3 mRNA CTD PMID:24356939 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Ier5 immediate early response 5 increases expression ISO Cyclophosphamide results in increased expression of IER5 mRNA CTD PMID:21527772 NCBI chr13:67,270,134...67,272,226
Ensembl chr13:67,270,135...67,272,227 		JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression ISO Cyclophosphamide results in increased expression of IFIT2 mRNA CTD PMID:15331540 NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635 		JBrowse link
G Ifna1 interferon, alpha 1 increases expression
multiple interactions		 EXP Cyclophosphamide results in increased expression of IFNA1 mRNA
naringin inhibits the reaction [Cyclophosphamide results in increased expression of IFNA1 mRNA]		 CTD PMID:33992719 NCBI chr 5:103,095,767...103,098,260 JBrowse link
G Ifng interferon gamma affects expression
multiple interactions
decreases secretion
increases expression
decreases expression		 ISO
EXP		 Cyclophosphamide affects the expression of IFNG mRNA
[Cyclophosphamide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA
Cyclophosphamide results in decreased secretion of IFNG protein
Cyclophosphamide results in increased expression of IFNG mRNA
Cyclophosphamide results in decreased expression of IFNG mRNA
Cyclophosphamide results in increased expression of IFNG protein
(4-formyl-9-methoxy-5-methyl-naphtho(2,3-b)furan-3-yl)methyl acetate inhibits the reaction [Cyclophosphamide results in decreased secretion of IFNG protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IFNG mRNA]; IFNG protein inhibits the reaction [Cyclophosphamide results in increased abundance of Nitric Oxide]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IFNG mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IFNG protein]		 CTD PMID:10607705 PMID:11006010 PMID:11014644 PMID:15331540 PMID:18848347 More... NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifngr1 interferon gamma receptor 1 decreases expression ISO Cyclophosphamide results in decreased expression of IFNGR1 mRNA CTD PMID:21041162 NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of IFRD1 mRNA CTD PMID:24356939 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990 		JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 affects response to substance ISO IGF2BP3 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects response to substance
decreases expression		 ISO
EXP		 IGFBP3 protein affects the susceptibility to Cyclophosphamide
Cyclophosphamide results in decreased expression of IGFBP3 mRNA		 CTD PMID:16141653 PMID:16217747 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 multiple interactions ISO IGFBP4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression ISO Cyclophosphamide results in decreased expression of IGFBP5 mRNA CTD PMID:15331540 PMID:20849824 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156 		JBrowse link
G Igkc immunoglobulin kappa constant decreases expression ISO Cyclophosphamide results in decreased expression of IGKC mRNA CTD PMID:15331540
G Il10 interleukin 10 decreases expression
multiple interactions
increases expression		 ISO
EXP		 Cyclophosphamide results in decreased expression of IL10 mRNA
[Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL10 protein
Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein]
Cyclophosphamide results in increased expression of IL10 mRNA
Cyclophosphamide results in increased expression of IL10 protein		 CTD PMID:11014644 PMID:11948286 PMID:18848347 PMID:21068404 PMID:25451569 More... NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] results in decreased expression of [IL12A protein binds to IL12B protein] CTD PMID:29228376 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B affects expression
multiple interactions
increases expression		 ISO Cyclophosphamide affects the expression of IL12B mRNA
[Doxorubicin co-treated with Cyclophosphamide] results in decreased expression of [IL12A protein binds to IL12B protein]
Cyclophosphamide results in increased expression of IL12B mRNA		 CTD PMID:15331540 PMID:18957084 PMID:22842586 PMID:29228376 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 increases expression ISO Cyclophosphamide results in increased expression of IL13RA1 mRNA CTD PMID:21041162 NCBI chr  X:115,348,860...115,408,682
Ensembl chr  X:115,348,860...115,408,681 		JBrowse link
G Il15 interleukin 15 multiple interactions
decreases secretion		 ISO (4-formyl-9-methoxy-5-methyl-naphtho(2,3-b)furan-3-yl)methyl acetate inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein] CTD PMID:23395935 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha increases expression ISO Cyclophosphamide results in increased expression of IL15RA mRNA CTD PMID:21041162 NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278 		JBrowse link
G Il16 interleukin 16 decreases expression ISO Cyclophosphamide results in decreased expression of IL16 mRNA CTD PMID:21041162 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il17a interleukin 17A decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased expression of IL17A protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL17A protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL17A protein]		 CTD PMID:21880982 PMID:32151603 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il18 interleukin 18 increases expression EXP Cyclophosphamide results in increased expression of IL18 protein CTD PMID:18848347 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha increases expression
multiple interactions
affects response to substance		 ISO
EXP		 Cyclophosphamide results in increased expression of IL1A mRNA
[Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL1A protein
Cyclophosphamide results in increased expression of IL1A protein
IL1A promoter polymorphism affects the susceptibility to Cyclophosphamide		 CTD PMID:15331540 PMID:16636934 PMID:18848347 PMID:31651976 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
increases response to substance
multiple interactions		 ISO
EXP		 Cyclophosphamide results in increased expression of IL1B mRNA; Cyclophosphamide results in increased expression of IL1B protein
Cyclophosphamide results in decreased expression of IL1B protein
IL1B protein results in increased susceptibility to Cyclophosphamide
[Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL1B protein; [Doxorubicin co-treated with Cyclophosphamide] results in decreased expression of IL1B protein; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL1B protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL1B protein]; VIP protein inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]; naringin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]; Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]		 CTD PMID:8634684 PMID:11948286 PMID:15331540 PMID:18206168 PMID:18483878 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 increases expression
multiple interactions		 EXP Cyclophosphamide results in increased expression of IL1R1 mRNA
naringin inhibits the reaction [Cyclophosphamide results in increased expression of IL1R1 mRNA]		 CTD PMID:33992719 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO Cyclophosphamide results in increased expression of IL1RN mRNA CTD PMID:15331540 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 increases expression
decreases expression
decreases secretion
multiple interactions		 ISO
EXP		 Cyclophosphamide results in increased expression of IL2 mRNA
Cyclophosphamide results in decreased expression of IL2 mRNA
Cyclophosphamide results in decreased secretion of IL2 protein
(4-formyl-9-methoxy-5-methyl-naphtho(2,3-b)furan-3-yl)methyl acetate inhibits the reaction [Cyclophosphamide results in decreased secretion of IL2 protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL2 mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL2 mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL2 protein]
Cyclophosphamide results in decreased expression of IL2 protein		 CTD PMID:11006010 PMID:11948286 PMID:18848347 PMID:23395935 PMID:32151603 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il21 interleukin 21 multiple interactions
decreases expression		 ISO Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL21 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL21 protein] CTD PMID:32151603 NCBI chr 2:120,119,598...120,126,941
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Il23a interleukin 23 subunit alpha decreases secretion
decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased secretion of IL23A protein
Cyclophosphamide results in decreased expression of IL23A protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL23A protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL23A protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL23A protein]		 CTD PMID:23395935 PMID:32151603 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il3 interleukin 3 multiple interactions ISO [Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL3 protein CTD PMID:31651976 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions
increases expression		 ISO
EXP		 Cyclophosphamide results in decreased expression of IL4 mRNA; Cyclophosphamide results in decreased expression of IL4 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL4 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL4 protein]
Cyclophosphamide results in increased expression of IL4 mRNA; Cyclophosphamide results in increased expression of IL4 protein		 CTD PMID:11006010 PMID:11014644 PMID:11948286 PMID:18848347 PMID:22842586 More... NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 increases expression ISO
EXP		 Cyclophosphamide results in increased expression of IL5 mRNA; Cyclophosphamide results in increased expression of IL5 protein CTD PMID:11006010 PMID:18848347 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
decreases secretion		 ISO
EXP		 [Doxorubicin co-treated with Cyclophosphamide] results in decreased expression of IL6 protein; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL6 protein]; Sizofiran promotes the reaction [Cyclophosphamide results in increased expression of IL6 mRNA]; Sizofiran promotes the reaction [Cyclophosphamide results in increased expression of IL6 protein]
Cyclophosphamide results in increased expression of IL6 mRNA; Cyclophosphamide results in increased expression of IL6 protein
Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]		 CTD PMID:10052129 PMID:11948286 PMID:17010015 PMID:18848347 PMID:20126887 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ilf3 interleukin enhancer binding factor 3 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of ILF3 mRNA CTD PMID:16322899 NCBI chr 8:19,922,409...19,960,495
Ensembl chr 8:19,922,460...19,960,350 		JBrowse link
G Irag2 inositol 1,4,5-triphosphate receptor associated 2 decreases expression ISO Cyclophosphamide results in decreased expression of IRAG2 mRNA CTD PMID:21041162 NCBI chr 4:178,088,902...178,143,569
Ensembl chr 4:178,088,507...178,143,557 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of IRS1 mRNA CTD PMID:16322899 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression ISO Cyclophosphamide results in increased expression of ISG15 mRNA CTD PMID:21527772 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Isl2 ISL LIM homeobox 2 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of ISL2 mRNA CTD PMID:24356939 NCBI chr 8:55,923,805...55,928,790
Ensembl chr 8:55,923,805...55,928,790 		JBrowse link
G Itk IL2-inducible T-cell kinase decreases expression ISO Cyclophosphamide results in decreased expression of ITK mRNA CTD PMID:21041162 NCBI chr10:30,753,339...30,814,685
Ensembl chr10:30,753,344...30,814,685 		JBrowse link
G Jchain joining chain of multimeric IgA and IgM decreases expression ISO Cyclophosphamide results in decreased expression of JCHAIN mRNA CTD PMID:15331540 NCBI chr14:19,538,560...19,546,384
Ensembl chr14:19,538,952...19,546,298 		JBrowse link
G Kbtbd11 kelch repeat and BTB domain containing 11 decreases expression ISO Cyclophosphamide results in decreased expression of KBTBD11 mRNA CTD PMID:17403535 NCBI chr16:74,618,291...74,638,010
Ensembl chr16:74,615,792...74,637,736 		JBrowse link
G Kcnq4 potassium voltage-gated channel subfamily Q member 4 decreases expression ISO Cyclophosphamide results in decreased expression of KCNQ4 mRNA CTD PMID:20849824 NCBI chr 5:134,275,145...134,326,992
Ensembl chr 5:134,275,934...134,326,932 		JBrowse link
G Kdm1a lysine demethylase 1A multiple interactions
increases expression		 ISO Cyclophosphamide promotes the reaction [KDM1A protein results in decreased methylation of and results in decreased degradation of DNMT1 protein]
Cyclophosphamide results in increased expression of KDM1A protein		 CTD PMID:22007908 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
G Kdm2a lysine demethylase 2A increases expression EXP Cyclophosphamide results in increased expression of KDM2A mRNA CTD PMID:27281708 NCBI chr 1:201,612,427...201,682,359
Ensembl chr 1:201,612,453...201,680,787 		JBrowse link
G Kdm4b lysine demethylase 4B multiple interactions ISO KDM4B mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 9:1,158,737...1,237,228
Ensembl chr 9:1,158,752...1,236,543 		JBrowse link
G Kdr kinase insert domain receptor decreases expression
increases expression		 EXP Cyclophosphamide results in decreased expression of KDR mRNA; Cyclophosphamide results in decreased expression of KDR protein
Cyclophosphamide results in increased expression of KDR mRNA		 CTD PMID:18632792 PMID:19701751 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kif21b kinesin family member 21B decreases expression ISO Cyclophosphamide metabolite results in decreased expression of KIF21B mRNA CTD PMID:24356939 NCBI chr13:47,576,142...47,626,112
Ensembl chr13:47,576,160...47,626,127 		JBrowse link
G Kif3a kinesin family member 3a multiple interactions ISO KIF3A mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr10:37,725,930...37,761,183
Ensembl chr10:37,725,970...37,759,191 		JBrowse link
G Kitlg KIT ligand affects expression
increases expression
multiple interactions		 ISO Cyclophosphamide affects the expression of KITL mRNA
Cyclophosphamide results in increased expression of KITL mRNA
[Cyclophosphamide co-treated with Sizofiran] results in increased expression of KITL mRNA		 CTD PMID:10052129 PMID:12624490 PMID:12662436 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Klf13 Kruppel-like factor 13 decreases expression ISO Cyclophosphamide results in decreased expression of KLF13 mRNA CTD PMID:21041162 NCBI chr 1:117,505,857...117,536,626
Ensembl chr 1:117,503,602...117,551,227 		JBrowse link
G Klf2 Kruppel-like factor 2 increases expression ISO Cyclophosphamide results in increased expression of KLF2 mRNA CTD PMID:21041162 NCBI chr16:17,521,773...17,523,723
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
G Klf4 Kruppel like factor 4 decreases response to substance ISO KLF4 results in decreased susceptibility to Cyclophosphamide CTD PMID:21833590 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Klf5 Kruppel-like factor 5 affects response to substance ISO KLF5 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445 		JBrowse link
G Krcc1 lysine-rich coiled-coil 1 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of KRCC1 mRNA CTD PMID:24356939 NCBI chr 4:103,261,566...103,274,672
Ensembl chr 4:103,261,536...103,277,156 		JBrowse link
G Krt8 keratin 8 decreases expression ISO Cyclophosphamide results in decreased expression of KRT8 mRNA CTD PMID:21621594 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728 		JBrowse link
G Krt80 keratin 80 increases expression ISO Cyclophosphamide results in increased expression of KRT80 mRNA CTD PMID:21527772 NCBI chr 7:132,464,807...132,485,026
Ensembl chr 7:132,463,218...132,485,508 		JBrowse link
G Lama5 laminin subunit alpha 5 increases expression
multiple interactions		 ISO Cyclophosphamide results in increased expression of LAMA5 mRNA
5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline inhibits the reaction [Cyclophosphamide results in increased expression of LAMA5 mRNA]		 CTD PMID:30760223 NCBI chr 3:167,270,296...167,318,370
Ensembl chr 3:167,270,296...167,318,451 		JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO Cyclophosphamide results in increased expression of LAMC2 mRNA CTD PMID:21527772 NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Lasp1 LIM and SH3 protein 1 decreases expression EXP Cyclophosphamide results in decreased expression of LASP1 mRNA CTD PMID:27281708 NCBI chr10:82,795,177...82,835,659
Ensembl chr10:82,795,137...82,943,292 		JBrowse link
G Lat linker for activation of T cells decreases expression ISO Cyclophosphamide results in decreased expression of LAT mRNA CTD PMID:21041162 NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases expression ISO Cyclophosphamide results in decreased expression of LCK mRNA CTD PMID:21041162 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Lcn2 lipocalin 2 increases expression
multiple interactions		 ISO
EXP		 Cyclophosphamide results in increased expression of LCN2 mRNA
[Cyclophosphamide co-treated with Mecamylamine] results in increased expression of LCN2 mRNA		 CTD PMID:15331540 PMID:18433785 PMID:20623750 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Ldhb lactate dehydrogenase B affects response to substance ISO LDHB protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Cyclophosphamide results in decreased expression of LEF1 mRNA CTD PMID:21041162 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Lgals1 galectin 1 increases expression ISO Cyclophosphamide results in increased expression of LGALS1 mRNA CTD PMID:17403535 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Lgals7 galectin 7 increases expression ISO Cyclophosphamide results in increased expression of LGALS7 mRNA CTD PMID:21527772 NCBI chr 1:84,148,612...84,152,016
Ensembl chr 1:84,150,252...84,152,015 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases secretion
multiple interactions		 EXP Cyclophosphamide results in decreased secretion of LHB protein
sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in decreased secretion of LHB protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of LHB protein]		 CTD PMID:25446862 PMID:32197949 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lhx2 LIM homeobox 2 decreases expression EXP Cyclophosphamide results in decreased expression of LHX2 mRNA CTD PMID:27281708 NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908 		JBrowse link
G Limd1 LIM domain containing 1 increases expression EXP Cyclophosphamide results in increased expression of LIMD1 mRNA CTD PMID:27281708 NCBI chr 8:123,121,363...123,168,476
Ensembl chr 8:123,122,460...123,167,714 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Cyclophosphamide results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046 		JBrowse link
G Lmnb1 lamin B1 multiple interactions ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of LMNB1 protein CTD PMID:15582267 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502 		JBrowse link
G Lonrf2 LON peptidase N-terminal domain and ring finger 2 increases expression EXP Cyclophosphamide results in increased expression of LONRF2 mRNA CTD PMID:27281708 NCBI chr 9:41,033,125...41,070,551
Ensembl chr 9:41,034,628...41,070,649 		JBrowse link
G Lsg1 large 60S subunit nuclear export GTPase 1 decreases expression ISO Cyclophosphamide results in decreased expression of LSG1 mRNA CTD PMID:20849824 NCBI chr11:70,132,919...70,168,526
Ensembl chr11:70,143,847...70,168,518 		JBrowse link
G Ltbr lymphotoxin beta receptor increases expression ISO Cyclophosphamide results in increased expression of LTBR mRNA CTD PMID:21041162 NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539 		JBrowse link
G Ltf lactotransferrin decreases expression ISO Cyclophosphamide results in decreased expression of LTF mRNA CTD PMID:21621594 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795 		JBrowse link
G Maged1 MAGE family member D1 affects response to substance ISO MAGED1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr  X:59,422,715...59,429,381
Ensembl chr  X:59,422,717...59,429,364 		JBrowse link
G Man2b2 mannosidase, alpha, class 2B, member 2 decreases expression EXP Cyclophosphamide results in decreased expression of MAN2B2 mRNA CTD PMID:27281708 NCBI chr14:73,969,079...73,994,089 JBrowse link
G Maoa monoamine oxidase A increases expression ISO Cyclophosphamide results in increased expression of MAOA mRNA CTD PMID:17403535 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 affects expression EXP Cyclophosphamide affects the expression of MAP3K12 mRNA CTD PMID:18246545 NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
increases expression		 ISO
EXP		 Cyclophosphamide results in increased phosphorylation of MAPK1 protein
Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Cyclophosphamide results in increased expression of MAPK1 mRNA; Cyclophosphamide results in increased expression of MAPK1 protein modified form		 CTD PMID:11599041 PMID:15733095 PMID:17110531 PMID:17409261 PMID:19638304 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
decreases expression
affects expression		 ISO
EXP		 [Doxorubicin co-treated with Cyclophosphamide] affects the expression of MAPK14 mRNA
Cyclophosphamide results in decreased expression of MAPK14 mRNA
Cyclophosphamide affects the expression of MAPK14 mRNA		 CTD PMID:16322899 PMID:18246545 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
multiple interactions
increases phosphorylation		 EXP
ISO		 Cyclophosphamide results in increased expression of MAPK3 protein modified form
Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Cyclophosphamide results in increased phosphorylation of MAPK3 protein		 CTD PMID:15733095 PMID:17110531 PMID:17409261 PMID:19638304 PMID:19696094 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions EXP Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK7 protein CTD PMID:17110531 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO
EXP		 Cyclophosphamide results in increased phosphorylation of MAPK8 protein
Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK8 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK8 protein]
GSTP1 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; GSTP2 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; Mesna inhibits the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; Mesna inhibits the reaction [GSTP1 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]]; Mesna inhibits the reaction [GSTP2 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]]		 CTD PMID:19696094 PMID:19996110 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK9 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK9 protein] CTD PMID:19996110 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO MAPT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 decreases expression EXP Cyclophosphamide results in decreased expression of MARCHF7 mRNA CTD PMID:27281708 NCBI chr 3:44,680,229...44,720,172
Ensembl chr 3:44,681,632...44,720,168 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases expression ISO Cyclophosphamide results in increased expression of MARCKS mRNA CTD PMID:17403535 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 decreases expression ISO Cyclophosphamide results in decreased expression of MCM5 mRNA CTD PMID:21041162 NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389 		JBrowse link
G Mdfic MyoD family inhibitor domain containing decreases expression ISO Cyclophosphamide results in decreased expression of MDFIC mRNA CTD PMID:17403535 NCBI chr 4:43,972,310...44,052,162
Ensembl chr 4:43,972,507...44,052,161 		JBrowse link
G Med13l mediator complex subunit 13L multiple interactions ISO MED13L mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr12:37,807,596...38,004,485
Ensembl chr12:37,808,285...38,004,473 		JBrowse link
G Melk maternal embryonic leucine zipper kinase multiple interactions ISO MELK mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 5:58,540,393...58,600,937
Ensembl chr 5:58,540,449...58,600,937 		JBrowse link
G Metrn meteorin, glial cell differentiation regulator multiple interactions ISO METRN mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr10:14,816,684...14,818,702
Ensembl chr10:14,816,572...14,818,701 		JBrowse link
G Mfge8 milk fat globule EGF and factor V/VIII domain containing decreases expression ISO Cyclophosphamide results in decreased expression of MFGE8 mRNA CTD PMID:15331540 NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:133,064,665...133,080,073 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression
decreases response to substance		 ISO Cyclophosphamide results in decreased expression of MGMT mRNA
MGMT protein results in decreased susceptibility to Cyclophosphamide		 CTD PMID:15741301 PMID:17403535 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases expression EXP Cyclophosphamide results in decreased expression of MGST1 mRNA CTD PMID:11906922 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions EXP Cyclophosphamide affects the localization of and affects the expression of MIF protein; Cyclophosphamide promotes the reaction [MIF protein binds to CXCR4 protein] CTD PMID:19066630 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Cyclophosphamide results in decreased expression of MKI67 protein CTD PMID:33737021 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mlh1 mutL homolog 1 decreases expression EXP Cyclophosphamide results in decreased expression of MLH1 mRNA CTD PMID:11906922 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Mmel1 membrane metallo-endopeptidase-like 1 increases expression EXP Cyclophosphamide results in increased expression of MMEL1 mRNA CTD PMID:27281708 NCBI chr 5:165,431,278...165,461,716
Ensembl chr 5:165,431,343...165,461,716 		JBrowse link
G Mmp11 matrix metallopeptidase 11 decreases expression EXP Cyclophosphamide results in decreased expression of MMP11 mRNA CTD PMID:27281708 NCBI chr20:12,730,846...12,739,629
Ensembl chr20:12,730,836...12,739,628 		JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO Cyclophosphamide results in increased expression of MMP3 mRNA CTD PMID:15331540 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp8 matrix metallopeptidase 8 increases expression EXP Cyclophosphamide results in increased expression of MMP8 mRNA CTD PMID:27281708 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520 		JBrowse link
G Mnda myeloid cell nuclear differentiation antigen increases expression ISO Cyclophosphamide results in increased expression of IFI204 mRNA CTD PMID:21041162 NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201 		JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 affects response to substance ISO MPC2 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase affects expression EXP Cyclophosphamide affects the expression of MPG mRNA CTD PMID:11906922 NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity		 EXP Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein]; Hemin inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein]; Rolipram inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein] CTD PMID:10749792 PMID:17979934 PMID:18710439 PMID:25451569 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mr1 major histocompatibility complex, class I-related increases expression ISO Cyclophosphamide results in increased expression of MR1 mRNA CTD PMID:21527772 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970 		JBrowse link
G Ms4a3 membrane spanning 4-domains A3 decreases expression ISO Cyclophosphamide results in decreased expression of MS4A3 mRNA CTD PMID:17403535 NCBI chr 1:208,462,300...208,480,129
Ensembl chr 1:208,462,301...208,480,101 		JBrowse link
G Msh2 mutS homolog 2 decreases expression EXP Cyclophosphamide results in decreased expression of MSH2 mRNA CTD PMID:11056294 PMID:11906922 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh3 mutS homolog 3 decreases expression EXP Cyclophosphamide results in decreased expression of MSH3 mRNA CTD PMID:11906922 NCBI chr 2:23,444,326...23,585,777 JBrowse link
G Mss51 MSS51 mitochondrial translational activator increases expression EXP Cyclophosphamide results in increased expression of MSS51 mRNA CTD PMID:27281708 NCBI chr15:3,805,240...3,819,385
Ensembl chr15:3,807,516...3,819,385 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases expression ISO Cyclophosphamide metabolite results in decreased expression of MTHFD2 mRNA CTD PMID:24356939 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase decreases expression EXP Cyclophosphamide results in decreased expression of MTR mRNA CTD PMID:27281708 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Muc13 mucin 13, cell surface associated increases expression ISO Cyclophosphamide results in increased expression of MUC13 mRNA CTD PMID:15331540 NCBI chr11:66,957,208...66,980,264
Ensembl chr11:66,960,595...66,984,727 		JBrowse link
G Mxi1 MAX interactor 1, dimerization protein affects response to substance ISO MXI1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681 		JBrowse link
G Myh10 myosin heavy chain 10 affects response to substance ISO MYH10 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr10:53,393,901...53,525,174
Ensembl chr10:53,394,389...53,525,165 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of NAIP mRNA CTD PMID:16322899 NCBI chr 2:31,507,423...31,559,098 JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression ISO Cyclophosphamide results in increased expression of NAMPT mRNA CTD PMID:21041162 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Nanos1 nanos C2HC-type zinc finger 1 increases expression ISO Cyclophosphamide metabolite results in increased expression of NANOS1 mRNA CTD PMID:24356939 NCBI chr 1:259,897,659...259,901,501
Ensembl chr 1:259,897,939...259,898,730 		JBrowse link
G Nasp nuclear autoantigenic sperm protein increases expression EXP Cyclophosphamide results in increased expression of NASP mRNA CTD PMID:16141653 NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928 		JBrowse link
G Ncoa7 nuclear receptor coactivator 7 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of NCOA7 mRNA CTD PMID:24356939 NCBI chr 1:26,856,228...27,016,950
Ensembl chr 1:26,856,530...27,015,871 		JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 decreases expression ISO Cyclophosphamide results in decreased expression of NDUFS2 mRNA CTD PMID:15331540 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420 		JBrowse link
G Neto2 neuropilin and tolloid like 2 increases expression ISO Cyclophosphamide results in increased expression of NETO2 mRNA CTD PMID:21527772 NCBI chr19:21,344,299...21,418,182
Ensembl chr19:21,344,289...21,417,023 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 decreases expression ISO Cyclophosphamide results in decreased expression of NFATC3 mRNA CTD PMID:21041162 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases response to substance
increases expression
decreases expression		 EXP
ISO		 [astaxanthine co-treated with Cyclophosphamide] results in increased expression of NFE2L2 protein; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 protein]
Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of CAT protein]; Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of GCLC protein]; Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Cyclophosphamide results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of CAT protein]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]
NFE2L2 gene mutant form results in increased susceptibility to Cyclophosphamide
Cyclophosphamide results in increased expression of NFE2L2 protein		 CTD PMID:20038455 PMID:20433640 PMID:27633142 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfe2l3 NFE2 like bZIP transcription factor 3 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of NFE2L3 mRNA CTD PMID:24356939 NCBI chr 4:80,506,756...80,534,629
Ensembl chr 4:80,506,756...80,534,629 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions		 ISO Cyclophosphamide results in increased phosphorylation of NFKBIA protein
ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased phosphorylation of NFKBIA protein]		 CTD PMID:30506662 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression ISO Cyclophosphamide results in increased expression of NFKBIZ mRNA CTD PMID:15331540 NCBI chr11:44,782,676...44,810,723
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Ngf nerve growth factor multiple interactions
increases expression
decreases expression		 ISO
EXP		 3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester inhibits the reaction [Cyclophosphamide results in increased expression of NGF protein]; Cyclophosphamide promotes the reaction [NGF results in increased expression of VEGFA mRNA]; VIP protein affects the reaction [Cyclophosphamide results in increased expression of NGF protein]
Cyclophosphamide results in decreased expression of NGF protein
Cyclophosphamide results in increased expression of NGF mRNA; Cyclophosphamide results in increased expression of NGF protein
NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of AKT1 protein]; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK8 protein]; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK9 protein]; rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NGF protein]		 CTD PMID:10683293 PMID:16879691 PMID:18299998 PMID:18632792 PMID:19996110 More... NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor increases expression EXP Cyclophosphamide results in increased expression of NGFR mRNA; Cyclophosphamide results in increased expression of NGFR protein CTD PMID:8817519 PMID:18189308 PMID:18842820 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nid1 nidogen 1 affects response to substance ISO NID1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr17:86,085,046...86,158,277
Ensembl chr17:86,085,077...86,158,267 		JBrowse link
G Nkain1 Sodium/potassium transporting ATPase interacting 1 multiple interactions ISO NKAIN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 5:142,747,702...142,792,665
Ensembl chr 5:142,747,505...142,791,863 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 increases expression EXP Cyclophosphamide results in increased expression of NME1 mRNA CTD PMID:11599041 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
increases activity		 EXP
ISO		 Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 mRNA]; Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; ginkgolide B inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 mRNA]; Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]
Cyclophosphamide results in increased expression of NOS2 mRNA; Cyclophosphamide results in increased expression of NOS2 protein		 CTD PMID:9006340 PMID:10607705 PMID:11046124 PMID:15821589 PMID:16879691 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases activity
increases expression		 EXP Cyclophosphamide results in decreased activity of NOS3 protein
Cyclophosphamide results in increased expression of NOS3 protein		 CTD PMID:9006340 PMID:16125470 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppb natriuretic peptide B increases expression ISO Cyclophosphamide results in increased expression of NPPB protein CTD PMID:17562616 PMID:18548196 PMID:18999883 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nprl2 NPR2-like, GATOR1 complex subunit decreases expression ISO Cyclophosphamide results in decreased expression of NPRL2 mRNA CTD PMID:20849824 NCBI chr 8:108,215,823...108,218,996
Ensembl chr 8:108,215,814...108,218,996 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions
increases expression		 EXP
ISO		 Cyclophosphamide results in decreased expression of NQO1 mRNA; Cyclophosphamide results in decreased expression of NQO1 protein
Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Cyclophosphamide results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]
Cyclophosphamide results in increased expression of NQO1 protein
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NQO1 protein; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]; sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]		 CTD PMID:11906922 PMID:20038455 PMID:20433640 PMID:21041162 PMID:27633142 More... NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression EXP Cyclophosphamide results in decreased expression of NR1H4 mRNA CTD PMID:28391356 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO Cyclophosphamide results in increased activity of NR1I2 protein
[Cyclophosphamide results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; [Cyclophosphamide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Cyclophosphamide binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [Cyclophosphamide results in increased expression of ABCB1 protein]		 CTD PMID:17041008 PMID:18839173 PMID:20041327 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Cyclophosphamide results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA CTD PMID:17041008 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr2c2 nuclear receptor subfamily 2, group C, member 2 increases expression EXP Cyclophosphamide results in increased expression of NR2C2 mRNA CTD PMID:27281708 NCBI chr 4:124,610,216...124,666,813
Ensembl chr 4:124,608,960...124,661,902 		JBrowse link
G Nrap nebulin-related anchoring protein increases expression EXP Cyclophosphamide results in increased expression of NRAP mRNA CTD PMID:27281708 NCBI chr 1:255,350,113...255,427,704
Ensembl chr 1:255,350,113...255,427,693 		JBrowse link
G Nrdc nardilysin convertase decreases expression EXP Cyclophosphamide results in decreased expression of NRD1 mRNA CTD PMID:27281708 NCBI chr 5:123,755,807...123,818,910
Ensembl chr 5:123,755,806...123,818,595 		JBrowse link
G Nrg1 neuregulin 1 increases expression ISO Cyclophosphamide results in increased expression of NRG1 mRNA CTD PMID:21527772 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Nrp1 neuropilin 1 decreases expression
increases expression		 ISO
EXP		 Cyclophosphamide results in decreased expression of NRP1 mRNA
Cyclophosphamide results in increased expression of NRP1 mRNA		 CTD PMID:15331540 PMID:18632792 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nrp2 neuropilin 2 increases expression EXP Cyclophosphamide results in increased expression of NRP2 mRNA CTD PMID:18632792 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958 		JBrowse link
G Nt5c2 5'-nucleotidase, cytosolic II increases expression ISO Cyclophosphamide results in increased expression of NT5C2 mRNA CTD PMID:20849824 NCBI chr 1:245,770,993...245,896,925
Ensembl chr 1:245,772,277...245,897,913 		JBrowse link
G Ntf3 neurotrophin 3 increases expression EXP Cyclophosphamide results in increased expression of NTF3 mRNA CTD PMID:10683293 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Ntf4 neurotrophin 4 increases expression EXP Cyclophosphamide results in increased expression of NTF4 mRNA CTD PMID:10683293 NCBI chr 1:95,893,560...95,896,391
Ensembl chr 1:95,893,457...95,897,243 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions EXP Cyclophosphamide results in increased phosphorylation of and results in increased expression of NTRK1 protein CTD PMID:12412144 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions EXP Cyclophosphamide results in increased phosphorylation of and results in increased expression of NTRK2 protein CTD PMID:12412144 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Nupl2 nucleoporin like 2 increases expression EXP Cyclophosphamide results in increased expression of NUPL2 mRNA CTD PMID:27281708 NCBI chr 4:10,985,554...11,002,591
Ensembl chr 4:10,985,554...11,002,591 		JBrowse link
G Ocln occludin decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased expression of OCLN protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of OCLN protein]		 CTD PMID:32151603 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150