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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nitrogen mustard
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Accession:CHEBI:37598 term browser browse the term
Definition:Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Synonyms:related_synonym: nitrogen mustard compound;   nitrogen mustard compounds;   nitrogen mustards
 alt_id: MESH:D009588
 xref_mesh: MESH:D009588
 xref: Wikipedia:Nitrogen_mustard

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nitrogen mustard term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
decreases expression		 ISO caffeic acid phenethyl ester promotes the reaction [Nitrogen Mustard Compounds results in decreased expression of AHR protein] CTD PMID:17204746 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Alb albumin increases alkylation ISO Nitrogen Mustard Compounds results in increased alkylation of ALB protein CTD PMID:18269793 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
multiple interactions		 ISO Nitrogen Mustard Compounds results in decreased expression of BRCA1 mRNA
Cycloheximide inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of BRCA1 mRNA]		 CTD PMID:10344722 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681 		JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions
increases expression
decreases expression		 ISO Cycloheximide inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of BRCA2 mRNA]
Nitrogen Mustard Compounds results in increased expression of BRCA2 mRNA		 CTD PMID:10344722 PMID:27342729 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748 		JBrowse link
G Cdh2 cadherin 2 decreases expression
multiple interactions		 ISO Nitrogen Mustard Compounds results in decreased expression of CDH2 mRNA; Nitrogen Mustard Compounds results in decreased expression of CDH2 protein
Plant Extracts inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of CDH2 mRNA]; Plant Extracts inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of CDH2 protein]		 CTD PMID:18572855 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684 		JBrowse link
G Dhfr dihydrofolate reductase decreases response to substance ISO DHFR protein polymorphism results in decreased susceptibility to Nitrogen Mustard Compounds CTD PMID:12872145 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO Nitrogen Mustard Compounds results in decreased expression of ERBB2 mRNA CTD PMID:16417271 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728 		JBrowse link
G Fancd2 FA complementation group D2 increases expression ISO Nitrogen Mustard Compounds results in increased expression of FANCD2 mRNA; Nitrogen Mustard Compounds results in increased expression of FANCD2 protein CTD PMID:27342729 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases response to substance EXP GSTA3 protein results in decreased susceptibility to Nitrogen Mustard Compounds CTD PMID:9414483 PMID:12872145 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression		 ISO MGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of H2AX protein]; Nitrogen Mustard Compounds results in decreased expression of and results in increased phosphorylation of H2AX protein
Nitrogen Mustard Compounds results in increased expression of H2AX mRNA; Nitrogen Mustard Compounds results in increased expression of H2AX protein		 CTD PMID:27342729 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects response to substance ISO IGF1R protein affects the susceptibility to Nitrogen Mustard Compounds CTD PMID:15499378 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions
decreases expression		 ISO MGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of H2AX protein]; MGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of SPRTN protein]
Nitrogen Mustard Compounds results in decreased expression of MGMT mRNA		 CTD PMID:27342729 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions		 ISO Nitrogen Mustard Compounds results in increased expression of NFE2L2 protein
caffeic acid phenethyl ester promotes the reaction [Nitrogen Mustard Compounds results in increased expression of NFE2L2 protein]		 CTD PMID:17204746 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases degradation ISO Nitrogen Mustard Compounds results in increased degradation of NFKBIA protein CTD PMID:17204746 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 multiple interactions
increases phosphorylation		 ISO caffeic acid phenethyl ester inhibits the reaction [Nitrogen Mustard Compounds results in increased phosphorylation of RPS6KA2 protein] CTD PMID:17204746 NCBI chr 1:53,219,346...53,499,445
Ensembl chr 1:53,360,157...53,499,445 		JBrowse link
G Sprtn SprT-like N-terminal domain multiple interactions
increases expression		 ISO MGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of SPRTN protein]
Nitrogen Mustard Compounds results in increased expression of SPRTN mRNA; Nitrogen Mustard Compounds results in increased expression of SPRTN protein		 CTD PMID:27342729 NCBI chr19:57,649,901...57,657,158
Ensembl chr19:57,650,163...57,654,864 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation		 ISO caffeic acid phenethyl ester inhibits the reaction [Nitrogen Mustard Compounds results in increased phosphorylation of TP53 protein] CTD PMID:17204746 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Vim vimentin decreases expression ISO Nitrogen Mustard Compounds results in decreased expression of VIM mRNA; Nitrogen Mustard Compounds results in decreased expression of VIM protein CTD PMID:17192600 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 affects response to substance ISO XRCC5 protein affects the susceptibility to Nitrogen Mustard Compounds CTD PMID:10717383 NCBI chr 9:79,659,275...79,748,050
Ensembl chr 9:79,659,251...79,748,078 		JBrowse link
4-hydroperoxycyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase increases expression ISO perfosfamide results in increased expression of ABL1 mRNA CTD PMID:19429390 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388 		JBrowse link
G Actb actin, beta decreases expression ISO perfosfamide results in decreased expression of ACTB mRNA CTD PMID:19429390 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841 		JBrowse link
G Agt angiotensinogen decreases response to substance ISO AGT protein results in decreased susceptibility to perfosfamide CTD PMID:11034089 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
increases response to substance		 ISO Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of AIFM1 protein]; perfosfamide results in increased expression of and results in increased localization of AIFM1 protein
AIFM1 results in increased susceptibility to perfosfamide		 CTD PMID:18034189 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 affects response to substance ISO AKR1B10 protein affects the susceptibility to perfosfamide CTD PMID:18473730 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases response to substance ISO ALDH1A1 protein results in decreased susceptibility to perfosfamide CTD PMID:8662658 PMID:16614850 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases response to substance ISO ALDH1A2 protein results in decreased susceptibility to perfosfamide CTD PMID:22079344 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489 		JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 affects response to substance ISO ALDH1B1 protein affects the susceptibility to perfosfamide CTD PMID:18473730 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases response to substance ISO ALDH2 protein results in decreased susceptibility to perfosfamide CTD PMID:22079344 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 decreases response to substance ISO ALDH3A1 protein results in decreased susceptibility to perfosfamide CTD PMID:16614850 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression EXP perfosfamide results in decreased expression of APEX1 mRNA CTD PMID:11754170 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects folding
increases expression		 ISO Acetylcysteine inhibits the reaction [perfosfamide affects the folding of BAX protein]; Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of BAX]; perfosfamide results in increased expression of and results in increased localization of BAX
perfosfamide results in increased expression of BAX protein		 CTD PMID:16488414 PMID:18034189 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO perfosfamide results in increased expression of BBC3 mRNA CTD PMID:17068108 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B decreases expression ISO perfosfamide results in decreased expression of BMPR1B mRNA CTD PMID:19429390 NCBI chr 2:247,392,195...247,662,026
Ensembl chr 2:247,403,920...247,446,882 		JBrowse link
G C1d C1D nuclear receptor corepressor increases expression ISO perfosfamide results in increased expression of C1D mRNA CTD PMID:19429390 NCBI chr14:100,415,645...100,427,878
Ensembl chr14:100,415,668...100,427,260 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO perfosfamide results in increased activity of CASP3
perfosfamide promotes the reaction [TNF results in increased activity of CASP3 protein]		 CTD PMID:16488414 PMID:17434952 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 increases activity ISO perfosfamide results in increased activity of CASP9 protein CTD PMID:16488414 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO perfosfamide results in increased expression of CDKN1A
perfosfamide results in increased expression of CDKN1A mRNA; perfosfamide results in increased expression of CDKN1A protein		 CTD PMID:17068108 PMID:18034189 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression ISO perfosfamide results in decreased expression of CXCL9 mRNA CTD PMID:19429390 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO perfosfamide results in increased expression of E2F1 mRNA CTD PMID:19429390 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G Egr1 early growth response 1 decreases expression ISO perfosfamide results in decreased expression of EGR1 mRNA CTD PMID:19429390 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Endog endonuclease G increases response to substance
multiple interactions		 ISO ENDOG results in increased susceptibility to perfosfamide
Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of ENDOG protein]; perfosfamide results in increased expression of and results in increased localization of ENDOG protein		 CTD PMID:18034189 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592 		JBrowse link
G Epas1 endothelial PAS domain protein 1 increases expression ISO perfosfamide results in increased expression of EPAS1 protein CTD PMID:23251655 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265 		JBrowse link
G Epha6 Eph receptor A6 decreases expression ISO perfosfamide results in decreased expression of EPHA6 mRNA CTD PMID:19429390 NCBI chr11:41,867,607...42,843,800 JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO perfosfamide results in decreased expression of EYA1 mRNA CTD PMID:19429390 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142 		JBrowse link
G Faslg Fas ligand increases expression ISO perfosfamide results in increased expression of FASLG mRNA; perfosfamide results in increased expression of FASLG protein CTD PMID:14760101 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Foxf1 forkhead box F1 affects expression ISO perfosfamide affects the expression of FOXF1 mRNA CTD PMID:19429390 NCBI chr19:53,012,306...53,016,100
Ensembl chr19:53,012,332...53,016,086 		JBrowse link
G Gjc1 gap junction protein, gamma 1 increases expression ISO perfosfamide results in increased expression of GJC1 mRNA CTD PMID:19429390 NCBI chr10:90,781,408...90,912,440
Ensembl chr10:90,781,402...90,912,287 		JBrowse link
G Gli2 GLI family zinc finger 2 decreases expression ISO perfosfamide results in decreased expression of GLI2 mRNA CTD PMID:19429390 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression ISO perfosfamide results in increased expression of HES1 mRNA CTD PMID:19429390 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO perfosfamide results in increased expression of HIF1A mRNA; perfosfamide results in increased expression of HIF1A protein CTD PMID:19429390 PMID:23251655 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hoxa11 homeobox A11 decreases expression ISO perfosfamide results in decreased expression of HOXA11 mRNA CTD PMID:19429390 NCBI chr 4:82,296,888...82,301,419
Ensembl chr 4:82,298,152...82,300,503
Ensembl chr 4:82,298,152...82,300,503 		JBrowse link
G Hoxa13 homeo box A13 increases expression ISO perfosfamide results in increased expression of HOXA13 mRNA CTD PMID:19429390 Ensembl chr 4:82,228,017...82,229,397 JBrowse link
G Hoxd10 homeo box D10 increases expression ISO perfosfamide results in increased expression of HOXD10 mRNA CTD PMID:19429390 NCBI chr 3:61,614,133...61,617,342
Ensembl chr 3:61,613,774...61,617,367 		JBrowse link
G Hras HRas proto-oncogene, GTPase decreases expression ISO perfosfamide results in decreased expression of HRAS mRNA CTD PMID:19429390 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686 		JBrowse link
G Kl Klotho decreases expression ISO perfosfamide results in decreased expression of KL mRNA CTD PMID:19429390 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551 		JBrowse link
G Lig3 DNA ligase 3 decreases expression EXP perfosfamide results in decreased expression of LIG3 mRNA CTD PMID:11754170 NCBI chr10:70,134,734...70,158,051
Ensembl chr10:70,134,729...70,158,055 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO perfosfamide results in increased expression of MDM2 CTD PMID:18034189 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression EXP perfosfamide results in decreased expression of MGMT mRNA CTD PMID:11754170 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Mlh1 mutL homolog 1 decreases expression EXP perfosfamide results in decreased expression of MLH1 mRNA CTD PMID:11754170 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase decreases expression EXP perfosfamide results in decreased expression of MPG mRNA CTD PMID:11754170 NCBI chr10:15,661,768...15,667,995
Ensembl chr10:15,661,608...15,668,022 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression EXP perfosfamide results in decreased expression of MRE11A mRNA CTD PMID:11754170 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489 		JBrowse link
G Myo1b myosin Ib increases expression ISO perfosfamide results in increased expression of MYO1B mRNA CTD PMID:19429390 NCBI chr 9:54,706,005...54,766,054
Ensembl chr 9:54,558,202...54,766,054 		JBrowse link
G Myog myogenin increases expression ISO perfosfamide results in increased expression of MYOG mRNA CTD PMID:19429390 NCBI chr13:51,126,459...51,129,048
Ensembl chr13:51,126,459...51,129,048 		JBrowse link
G Ndn necdin, MAGE family member increases expression ISO perfosfamide results in increased expression of NDN mRNA CTD PMID:19429390 NCBI chr 1:122,981,755...122,983,354
Ensembl chr 1:122,981,755...122,983,351 		JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression ISO perfosfamide results in decreased expression of ODC1 mRNA CTD PMID:19429390 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927 		JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 decreases expression ISO perfosfamide results in decreased expression of PEA15 mRNA CTD PMID:19429390 NCBI chr13:90,579,844...90,589,466
Ensembl chr13:90,579,846...90,589,466 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO perfosfamide results in increased expression of PMAIP1 mRNA CTD PMID:17068108 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102 		JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component decreases expression EXP perfosfamide results in decreased expression of PMS1 mRNA CTD PMID:11754170 NCBI chr 9:53,120,656...53,206,520
Ensembl chr 9:53,120,656...53,206,516 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component decreases expression EXP perfosfamide results in decreased expression of PMS2 mRNA CTD PMID:11754170 NCBI chr12:12,714,394...12,738,654
Ensembl chr12:12,714,394...12,738,641 		JBrowse link
G Polb DNA polymerase beta decreases expression EXP perfosfamide results in decreased expression of POLB mRNA CTD PMID:11754170 NCBI chr16:74,237,001...74,260,272
Ensembl chr16:74,237,001...74,260,271 		JBrowse link
G Pold1 DNA polymerase delta 1, catalytic subunit decreases expression ISO perfosfamide results in decreased expression of POLD1 mRNA CTD PMID:19429390 NCBI chr 1:100,538,066...100,554,105
Ensembl chr 1:100,537,900...100,554,488 		JBrowse link
G Rad21 RAD21 cohesin complex component decreases expression ISO perfosfamide results in decreased expression of RAD21 mRNA CTD PMID:19429390 NCBI chr 7:91,511,755...91,538,673
Ensembl chr 7:91,511,756...91,538,673 		JBrowse link
G Rad50 RAD50 double strand break repair protein decreases expression EXP perfosfamide results in decreased expression of RAD50 mRNA CTD PMID:11754170 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142 		JBrowse link
G Rad51 RAD51 recombinase decreases expression EXP perfosfamide results in decreased expression of RAD51 mRNA CTD PMID:11754170 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917 		JBrowse link
G Sdf4 stromal cell derived factor 4 decreases expression ISO perfosfamide results in decreased expression of SDF4 mRNA CTD PMID:19429390 NCBI chr 5:173,425,922...173,444,478
Ensembl chr 5:173,425,907...173,444,620 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 decreases expression ISO perfosfamide results in decreased expression of SFRP2 mRNA CTD PMID:19429390 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764 		JBrowse link
G Slc30a4 solute carrier family 30 member 4 decreases expression ISO perfosfamide results in decreased expression of SLC30A4 mRNA CTD PMID:19429390 NCBI chr 3:114,805,919...114,828,154
Ensembl chr 3:114,805,922...114,828,154 		JBrowse link
G Smad1 SMAD family member 1 decreases expression ISO perfosfamide results in decreased expression of SMAD1 mRNA CTD PMID:19429390 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member affects response to substance ISO TAP1 protein affects the susceptibility to perfosfamide CTD PMID:18473730 NCBI chr20:3,979,302...3,989,669
Ensembl chr20:3,979,035...3,989,669 		JBrowse link
G Tcf12 transcription factor 12 increases expression ISO perfosfamide results in increased expression of TCF12 mRNA CTD PMID:19429390 NCBI chr 8:78,343,634...78,657,738
Ensembl chr 8:78,345,754...78,655,856 		JBrowse link
G Terc telomerase RNA component decreases expression ISO perfosfamide results in decreased expression of TERC mRNA CTD PMID:24571982 NCBI chr 2:116,432,723...116,433,110
Ensembl chr 2:116,432,691...116,433,110 		JBrowse link
G Tert telomerase reverse transcriptase decreases expression ISO perfosfamide results in decreased expression of TERT mRNA CTD PMID:24571982 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO perfosfamide promotes the reaction [TNF results in increased activity of CASP3 protein] CTD PMID:16488414 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [perfosfamide results in increased expression of TP53]
perfosfamide results in increased expression of and results in increased phosphorylation of and results in increased activity of TRP53 protein		 CTD PMID:17068108 PMID:18034189 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trim27 tripartite motif-containing 27 decreases expression ISO perfosfamide results in decreased expression of TRIM27 mRNA CTD PMID:19429390 NCBI chr17:45,613,863...45,626,212
Ensembl chr17:45,613,864...45,626,212 		JBrowse link
G Ttf1 transcription termination factor 1 decreases expression ISO perfosfamide results in decreased expression of TTF1 mRNA CTD PMID:19429390 NCBI chr 3:7,635,630...7,660,153
Ensembl chr 3:7,635,933...7,660,673 		JBrowse link
G Ubb ubiquitin B decreases expression ISO perfosfamide results in decreased expression of UBB mRNA CTD PMID:19429390 NCBI chr10:48,880,231...48,881,896
Ensembl chr10:48,881,049...48,881,881 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO perfosfamide results in increased expression of VEGFA mRNA CTD PMID:19429390 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vim vimentin decreases expression ISO perfosfamide results in decreased expression of VIM mRNA CTD PMID:19429390 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
G Wnt11 Wnt family member 11 increases expression ISO perfosfamide results in increased expression of WNT11 mRNA CTD PMID:19429390 NCBI chr 1:163,794,136...163,813,756
Ensembl chr 1:163,797,660...163,813,756 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases expression EXP perfosfamide results in decreased expression of XRCC1 mRNA CTD PMID:11754170 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression EXP perfosfamide results in decreased expression of XRCC5 mRNA CTD PMID:11754170 NCBI chr 9:79,659,275...79,748,050
Ensembl chr 9:79,659,251...79,748,078 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta decreases expression ISO perfosfamide results in decreased expression of YWHAZ mRNA CTD PMID:19429390 NCBI chr 7:75,573,553...75,598,295
Ensembl chr 7:75,574,967...75,597,276 		JBrowse link
4-hydroxycyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of ALOX5 mRNA CTD PMID:25833159 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303 		JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of BDKRB2 mRNA CTD PMID:25833159 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676 		JBrowse link
G Cd40 CD40 molecule multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of CD40 mRNA CTD PMID:25833159 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases chemical synthesis ISO CYP2B6 protein results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:24819615 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases chemical synthesis ISO CYP2C9 protein results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:24819615 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP2C19 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:30500380 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [CYP3A4 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:30500380 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL1R1 mRNA CTD PMID:25833159 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL2RG mRNA CTD PMID:25833159 NCBI chr  X:71,165,378...71,169,078
Ensembl chr  X:71,162,585...71,169,865 		JBrowse link
G Klk15 kallikrein-related peptidase 15 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of KLK15 mRNA CTD PMID:25833159 NCBI chr 1:99,393,283...99,401,339
Ensembl chr 1:99,398,248...99,401,126
Ensembl chr 1:99,398,248...99,401,126 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of MAPK14 mRNA CTD PMID:25833159 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
Aldophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
increases oxidation		 ISO [ALDH1A1 protein co-treated with NAD] results in increased oxidation of aldophosphamide
ALDH1A1 results in increased oxidation of aldophosphamide		 CTD PMID:8662658 PMID:10856427 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions ISO [ALDH3A1 protein co-treated with NAD] results in increased oxidation of aldophosphamide; [ALDH3A1 protein co-treated with NADP] results in increased oxidation of aldophosphamide CTD PMID:10856427 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876 		JBrowse link
chlorambucil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Chlorambucil results in increased expression of ABCB1 protein CTD PMID:15239124 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects export
decreases response to substance
increases response to substance
multiple interactions		 ISO ABCC1 protein affects the export of Chlorambucil analog
ABCC1 protein results in decreased susceptibility to Chlorambucil
ABCC1 protein results in increased susceptibility to Chlorambucil
buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased susceptibility to Chlorambucil]; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Chlorambucil]		 CTD PMID:10900222 PMID:11115505 PMID:12504668 PMID:14569069 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
multiple interactions		 ISO ABCC2 protein affects the export of Chlorambucil analog
ABCC2 protein promotes the reaction [GSTA1 protein results in decreased susceptibility to Chlorambucil]		 CTD PMID:14569069 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases expression ISO Chlorambucil results in decreased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases expression ISO Chlorambucil results in decreased expression of AKR1C2 mRNA CTD PMID:26198647 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341 		JBrowse link
G Asf1a anti-silencing function 1A histone chaperone decreases expression ISO Chlorambucil results in decreased expression of ASF1A mRNA CTD PMID:26198647 NCBI chr20:34,894,419...34,909,265
Ensembl chr20:34,894,419...34,909,265 		JBrowse link
G Aurka aurora kinase A increases expression ISO Chlorambucil results in increased expression of AURKA protein CTD PMID:22025197 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210 		JBrowse link
G Aurkb aurora kinase B decreases expression ISO Chlorambucil results in decreased expression of AURKB protein CTD PMID:22025197 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Chlorambucil results in increased expression of BAX protein CTD PMID:11699414 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Chlorambucil results in increased expression of BBC3 mRNA CTD PMID:17476690 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Chlorambucil results in decreased expression of BCL2 mRNA; Chlorambucil results in decreased expression of BCL2 protein
IL4 protein inhibits the reaction [Chlorambucil results in decreased expression of BCL2 protein]		 CTD PMID:8822937 PMID:11699414 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bik BCL2-interacting killer increases expression ISO Chlorambucil results in increased expression of BIK mRNA CTD PMID:26198647 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases response to substance ISO BIRC2 protein results in decreased susceptibility to Chlorambucil CTD PMID:10815900 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects expression
decreases expression		 ISO Chlorambucil affects the expression of BIRC5 mRNA
Chlorambucil results in decreased expression of BIRC5 protein		 CTD PMID:17476690 PMID:22025197 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Bmp5 bone morphogenetic protein 5 increases mutagenesis ISO Chlorambucil results in increased mutagenesis of BMP5 gene CTD PMID:10517996 NCBI chr 8:82,669,466...82,950,273
Ensembl chr 8:82,878,941...82,950,273 		JBrowse link
G Casp3 caspase 3 increases activity ISO Chlorambucil results in increased activity of CASP3 protein CTD PMID:11675354 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases activity ISO Chlorambucil results in increased activity of CASP8 protein CTD PMID:11675354 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cd59 CD59 molecule decreases lipidation EXP Chlorambucil results in decreased lipidation of CD59 protein CTD PMID:27931811 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621 		JBrowse link
G Cda cytidine deaminase decreases response to substance ISO CDA protein results in decreased susceptibility to Chlorambucil CTD PMID:10830723 NCBI chr 5:156,703,579...156,734,541
Ensembl chr 5:156,703,579...156,734,541 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO Chlorambucil analog results in increased phosphorylation of and results in decreased activity of CDK1 protein CTD PMID:16861886 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Chlorambucil results in increased expression of CDKN1A protein CTD PMID:16039525 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Dhfr dihydrofolate reductase decreases response to substance ISO DHFR protein polymorphism results in decreased susceptibility to Chlorambucil CTD PMID:12872145 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453 		JBrowse link
G Ednrb endothelin receptor type B increases mutagenesis ISO Chlorambucil results in increased mutagenesis of EDNRB gene CTD PMID:10517996 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354 		JBrowse link
G Fancc FA complementation group C increases response to substance ISO FANCC protein results in increased susceptibility to Chlorambucil CTD PMID:16243825 NCBI chr17:826,512...955,703
Ensembl chr17:833,509...955,615 		JBrowse link
G Fancg FA complementation group G increases response to substance ISO FANCG protein results in increased susceptibility to Chlorambucil CTD PMID:16243825 NCBI chr 5:58,448,060...58,456,416
Ensembl chr 5:58,448,822...58,455,819 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Chlorambucil results in increased expression of FAS mRNA CTD PMID:11675354 PMID:17476690 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fbxo30 F-box protein 30 decreases expression ISO Chlorambucil results in decreased expression of FBXO30 mRNA CTD PMID:26198647 NCBI chr 1:5,366,119...5,389,774
Ensembl chr 1:5,366,379...5,388,069 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Chlorambucil CTD PMID:10900222 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Chlorambucil CTD PMID:10900222 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity
decreases response to substance
multiple interactions		 ISO Chlorambucil analog results in decreased activity of GSTA1 protein
GSTA1 protein results in decreased susceptibility to Chlorambucil
ABCC2 protein promotes the reaction [GSTA1 protein results in decreased susceptibility to Chlorambucil]; GSTA1 protein affects the metabolism of [Chlorambucil co-treated with Glutathione]		 CTD PMID:11115505 PMID:14569069 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases response to substance EXP GSTA3 protein results in decreased susceptibility to Chlorambucil CTD PMID:8044793 PMID:8860835 PMID:10830723 PMID:12872145 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases response to substance EXP GSTA5 protein results in decreased susceptibility to Chlorambucil CTD PMID:12076520 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases response to substance ISO GSTM1 protein results in decreased susceptibility to Chlorambucil CTD PMID:15044619 PMID:20067466 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects binding
increases metabolic processing
decreases response to substance
affects response to substance
multiple interactions		 ISO Chlorambucil binds to GSTP1 protein
GSTP1 protein results in increased metabolism of Chlorambucil
GSTP1 protein results in decreased susceptibility to Chlorambucil
GSTP1 gene affects the susceptibility to Chlorambucil
GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Chlorambucil]		 CTD PMID:10900222 PMID:11071881 PMID:18511072 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Chlorambucil analog results in increased phosphorylation of H2AX protein; Chlorambucil results in increased phosphorylation of H2AX protein CTD PMID:16861886 PMID:32482060 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein]; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of TP53]; IL4 protein inhibits the reaction [Chlorambucil results in decreased expression of BCL2 protein] CTD PMID:8822937 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil] CTD PMID:19608619 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779 		JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Chlorambucil results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642 		JBrowse link
G LOC100912489 histone H4-like decreases expression ISO Chlorambucil analog results in decreased expression of H4C3 mRNA; Chlorambucil results in decreased expression of H4C3 mRNA; Chlorambucil results in decreased expression of H4C3 protein CTD PMID:15556009 PMID:16861886 NCBI chr 4:170,144,871...170,145,311
Ensembl chr 4:170,144,951...170,145,262 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Chlorambucil results in increased expression of MDM2 mRNA CTD PMID:17476690 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
affects expression
increases expression		 ISO [Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein]
Chlorambucil affects the expression of MYC mRNA
Chlorambucil results in increased expression of MYC protein		 CTD PMID:8822937 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Myo5a myosin VA increases mutagenesis ISO Chlorambucil results in increased mutagenesis of MYO5A gene CTD PMID:10517996 NCBI chr 8:82,038,966...82,156,507
Ensembl chr 8:82,037,977...82,156,617 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects response to substance
increases response to substance		 ISO [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil]
[NFE2L2 affects the susceptibility to sulforafan] which affects the susceptibility to Chlorambucil
Buthionine Sulfoximine affects the reaction [[NFE2L2 affects the susceptibility to sulforafan] which affects the susceptibility to Chlorambucil]; Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforafan results in decreased susceptibility to Chlorambucil]]; NFE2L2 protein promotes the reaction [sulforafan results in decreased susceptibility to Chlorambucil]
NFE2L2 gene mutant form results in increased susceptibility to Chlorambucil		 CTD PMID:19303893 PMID:19608619 PMID:20932822 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A increases mutagenesis
multiple interactions		 EXP Chlorambucil results in increased mutagenesis of PIGA
Chlorambucil results in increased mutagenesis of and results in decreased activity of PIGA protein		 CTD PMID:22923490 PMID:27931811 NCBI chr  X:31,786,823...31,799,751
Ensembl chr  X:31,786,194...31,799,560 		JBrowse link
G Rad51 RAD51 recombinase increases expression ISO Chlorambucil results in increased expression of RAD51 protein CTD PMID:10473103 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917 		JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Chlorambucil affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:3,875,478...3,885,140
Ensembl chr20:3,875,706...3,881,461 		JBrowse link
G Sfn stratifin increases expression ISO Chlorambucil results in increased expression of SFN mRNA CTD PMID:18092340 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b affects expression ISO Chlorambucil affects the expression of TNFRSF10A mRNA CTD PMID:14614459 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO Chlorambucil results in increased expression of TP53; Chlorambucil results in increased expression of TP53 protein
[Theophylline co-treated with Chlorambucil] results in increased expression of TP53; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of TP53]		 CTD PMID:8822937 PMID:18092340 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity EXP Chlorambucil results in decreased activity of TXNRD1 protein CTD PMID:16085187 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases mutagenesis ISO Chlorambucil results in increased mutagenesis of TYRP1 gene CTD PMID:10517996 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083 		JBrowse link
cyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases expression
increases expression		 ISO
EXP		 [Cyclophosphamide results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; ABCB1 protein affects the susceptibility to [Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil]; ABCB1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; NR1I2 protein promotes the reaction [Cyclophosphamide results in increased expression of ABCB1 protein]
Cyclophosphamide results in decreased expression of ABCB1 mRNA; Cyclophosphamide results in decreased expression of ABCB1A mRNA		 CTD PMID:12576456 PMID:20041327 PMID:20623750 PMID:30563925 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases response to substance		 ISO ABCC1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]
ABCC1 protein results in decreased susceptibility to Cyclophosphamide		 CTD PMID:11778547 PMID:12576456 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO ABCG2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:12576456 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Abhd3 abhydrolase domain containing 3, phospholipase increases expression ISO Cyclophosphamide results in increased expression of ABHD3 mRNA CTD PMID:21527772 NCBI chr18:1,892,413...1,946,840
Ensembl chr18:1,892,413...1,946,840 		JBrowse link
G Abi2 abl-interactor 2 decreases expression EXP Cyclophosphamide results in decreased expression of ABI2 mRNA CTD PMID:27466211 NCBI chr 9:67,234,612...67,284,504
Ensembl chr 9:67,234,303...67,282,600 		JBrowse link
G Ace angiotensin I converting enzyme decreases expression EXP Cyclophosphamide results in decreased expression of ACE mRNA CTD PMID:27281708 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Ackr3 atypical chemokine receptor 3 increases expression EXP Cyclophosphamide results in increased expression of ACKR3 mRNA CTD PMID:20032115 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445 		JBrowse link
G Acod1 aconitate decarboxylase 1 increases expression ISO Cyclophosphamide results in increased expression of ACOD1 mRNA CTD PMID:15331540 NCBI chr15:93,612,968...93,622,322
Ensembl chr15:93,612,971...93,622,358 		JBrowse link
G Actb actin, beta decreases expression
affects expression		 ISO
EXP		 Cyclophosphamide results in decreased expression of ACTB mRNA
Cyclophosphamide affects the expression of ACTB mRNA		 CTD PMID:10859244 PMID:12167460 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841 		JBrowse link
G Adam24 a disintegrin and metallopeptidase domain 24 decreases expression EXP Cyclophosphamide results in decreased expression of ADAM24 mRNA CTD PMID:27281708 NCBI chr16:54,625,789...54,631,824
Ensembl chr16:54,625,847...54,628,458 		JBrowse link
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 increases expression EXP Cyclophosphamide results in increased expression of ADAMTS9 mRNA CTD PMID:27281708 NCBI chr 4:124,660,254...124,860,997
Ensembl chr 4:124,660,262...124,858,250 		JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 affects expression
increases expression		 EXP Cyclophosphamide affects the expression of ADCYAP1 mRNA
Cyclophosphamide results in increased expression of ADCYAP1 protein		 CTD PMID:9776515 PMID:10754506 PMID:18563302 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716 		JBrowse link
G Adcyap1r1 ADCYAP receptor type I affects expression EXP Cyclophosphamide affects the expression of ADCYAP1R1 mRNA CTD PMID:18563302 NCBI chr 4:85,662,809...85,711,696
Ensembl chr 4:85,662,892...85,711,696 		JBrowse link
G Adm adrenomedullin affects response to substance ISO ADM protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259 		JBrowse link
G Afp alpha-fetoprotein affects expression ISO Cyclophosphamide affects the expression of AFP protein CTD PMID:6177358 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923 		JBrowse link
G Agl amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase affects response to substance ISO AGL protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 2:219,788,234...219,843,189
Ensembl chr 2:219,788,234...219,842,986 		JBrowse link
G Akap2 A-kinase anchoring protein 2 increases expression ISO Cyclophosphamide results in increased expression of PALM2AKAP2 mRNA CTD PMID:17403535 NCBI chr 5:74,874,245...74,985,789
Ensembl chr 5:74,874,306...74,982,401 		JBrowse link
G Akap8 A-kinase anchoring protein 8 increases expression EXP Cyclophosphamide results in increased expression of AKAP8 mRNA CTD PMID:27281708 NCBI chr 7:14,323,298...14,339,953
Ensembl chr 7:14,324,104...14,351,918 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression		 EXP Cyclophosphamide results in increased phosphorylation of and results in increased activity of AKT1 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of AKT1 protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of AKT1 protein] CTD PMID:19996110 PMID:25446862 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alad aminolevulinate dehydratase multiple interactions ISO [Cyclophosphamide co-treated with Carmustine co-treated with Etoposide] results in decreased activity of ALAD protein CTD PMID:19162187 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346 		JBrowse link
G Alcam activated leukocyte cell adhesion molecule increases expression ISO Cyclophosphamide results in increased expression of ALCAM mRNA CTD PMID:21041162 NCBI chr11:50,780,735...50,985,083
Ensembl chr11:50,781,127...50,985,083 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects response to substance
increases expression
decreases response to substance		 ISO ALDH1A1 protein affects the susceptibility to Cyclophosphamide
Cyclophosphamide results in increased expression of ALDH1A1 mRNA
ALDH1A1 protein results in decreased susceptibility to Cyclophosphamide		 CTD PMID:12513786 PMID:17403535 PMID:18854779 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member increases expression ISO Cyclophosphamide results in increased expression of ALDH2 mRNA CTD PMID:17403535 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 affects response to substance ISO ALDH3A1 protein affects the susceptibility to Cyclophosphamide CTD PMID:18854779 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein decreases expression ISO Cyclophosphamide results in decreased expression of ALOX5AP mRNA CTD PMID:17403535 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154 		JBrowse link
G Alyref Aly/REF export factor decreases expression ISO Cyclophosphamide results in decreased expression of ALYREF mRNA CTD PMID:21041162 NCBI chr10:109,768,593...109,774,639
Ensembl chr10:109,770,876...109,774,639 		JBrowse link
G Amfr autocrine motility factor receptor multiple interactions ISO AMFR mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr19:11,473,538...11,509,500
Ensembl chr19:11,473,541...11,508,102 		JBrowse link
G Angpt1 angiopoietin 1 increases expression ISO Cyclophosphamide results in increased expression of ANGPT1 mRNA CTD PMID:17403535 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression ISO Cyclophosphamide results in decreased expression of APAF1 mRNA CTD PMID:29445054 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Cyclophosphamide results in increased expression of APEX1 mRNA CTD PMID:11599041 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082 		JBrowse link
G Apob apolipoprotein B decreases expression EXP Cyclophosphamide results in decreased expression of APOB mRNA CTD PMID:18246545 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997 		JBrowse link
G Apoe apolipoprotein E decreases expression
increases expression		 ISO Cyclophosphamide results in decreased expression of APOE mRNA
Cyclophosphamide results in increased expression of APOE mRNA		 CTD PMID:15331540 PMID:21041162 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G Arg1 arginase 1 increases expression
decreases expression
affects expression		 ISO
EXP		 Cyclophosphamide results in increased expression of ARG1 mRNA
Cyclophosphamide results in decreased expression of ARG1 mRNA
Cyclophosphamide affects the expression of ARG1 mRNA		 CTD PMID:18246545 PMID:21068404 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863 		JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta increases expression ISO Cyclophosphamide results in increased expression of ARHGDIB mRNA CTD PMID:21527772 NCBI chr 4:170,913,920...170,932,789
Ensembl chr 4:170,913,923...170,932,618 		JBrowse link
G Arhgef26 Rho guanine nucleotide exchange factor 26 increases expression ISO Cyclophosphamide results in increased expression of ARHGEF26 mRNA CTD PMID:20849824 NCBI chr 2:27,107,263...27,236,336
Ensembl chr 2:27,107,318...27,236,672 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Cyclophosphamide metabolite results in decreased expression of ASNS mRNA CTD PMID:24356939 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163 		JBrowse link
G Atf2 activating transcription factor 2 increases expression EXP Cyclophosphamide results in increased expression of ATF2 mRNA CTD PMID:11599041 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951 		JBrowse link
G Atf5 activating transcription factor 5 decreases expression ISO Cyclophosphamide results in decreased expression of ATF5 mRNA CTD PMID:17403535 NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522 		JBrowse link
G Atg3 autophagy related 3 decreases expression ISO Cyclophosphamide results in decreased expression of ATG3 mRNA CTD PMID:20849824 NCBI chr11:60,585,192...60,613,706
Ensembl chr11:60,585,171...60,613,718 		JBrowse link
G Atg5 autophagy related 5 decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased expression of ATG5 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of ATG5 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG5 protein]		 CTD PMID:32151603 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140 		JBrowse link
G Atg7 autophagy related 7 decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased expression of ATG7 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of ATG7 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG7 protein]		 CTD PMID:32151603 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124 		JBrowse link
G Aurkb aurora kinase B increases expression EXP Cyclophosphamide results in increased expression of AURKB mRNA CTD PMID:11599041 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991 		JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO Cyclophosphamide results in increased expression of AXL mRNA CTD PMID:21527772 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761 		JBrowse link
G B3galnt2 beta-1,3-N-acetylgalactosaminyltransferase 2 increases expression ISO Cyclophosphamide results in increased expression of B3GALNT2 mRNA CTD PMID:21527772 NCBI chr17:54,027,859...54,070,399
Ensembl chr17:54,027,859...54,070,399 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions		 EXP
ISO		 Cyclophosphamide results in increased expression of BAD mRNA
Cyclophosphamide results in increased expression of BAD protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased expression of BAD protein]		 CTD PMID:11599041 PMID:29753871 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bag1 BAG cochaperone 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BAG1 mRNA CTD PMID:16322899 NCBI chr 5:57,254,421...57,267,002
Ensembl chr 5:57,254,421...57,267,002 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP
ISO		 Cyclophosphamide results in increased expression of BAX mRNA; Cyclophosphamide results in increased expression of BAX protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]
Plant Extracts inhibits the reaction [Cyclophosphamide results in increased expression of BAX mRNA]; sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]		 CTD PMID:25446862 PMID:29753871 PMID:30506662 PMID:32197949 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression
multiple interactions		 EXP Cyclophosphamide results in increased expression of BBC3 mRNA
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BBC3 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BBC3 mRNA]		 CTD PMID:32197949 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 multiple interactions ISO BBS4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 8:64,115,005...64,154,432
Ensembl chr 8:64,121,392...64,154,396 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity		 ISO [Melphalan co-treated with Thiotepa co-treated with Cyclophosphamide] results in decreased expression of BCHE protein
Cyclophosphamide results in decreased activity of BCHE protein		 CTD PMID:4672170 PMID:4959505 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression		 ISO
EXP		 [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of BCL2 protein; [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BCL2 mRNA; [Doxorubicin co-treated with Dexamethasone co-treated with Vincristine co-treated with Cytarabine co-treated with Mercaptopurine co-treated with Methotrexate co-treated with Cyclophosphamide co-treated with Enzymes and Coenzymes] results in increased expression of BCL2 protein; BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP9 protein]
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]
Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 mRNA]; sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]
Cyclophosphamide results in decreased expression of BCL2 mRNA; Cyclophosphamide results in decreased expression of BCL2 protein
Cyclophosphamide results in increased expression of BCL2 mRNA		 CTD PMID:11723234 PMID:14503796 PMID:15582267 PMID:16322899 PMID:21182165 PMID:25446862 PMID:29753871 PMID:30506662 PMID:32197949 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP Cyclophosphamide results in increased expression of BCL2L1 mRNA CTD PMID:11599041 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bcl2l11 BCL2 like 11 increases expression
multiple interactions		 EXP Cyclophosphamide results in increased expression of BCL2L11 mRNA
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BCL2L11 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BCL2L11 mRNA]		 CTD PMID:32197949 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression ISO Cyclophosphamide results in increased expression of BCL2L2 mRNA CTD PMID:21041162 NCBI chr15:33,543,774...33,549,165
Ensembl chr15:33,544,312...33,549,164 		JBrowse link
G Bcl6 BCL6, transcription repressor decreases expression ISO Cyclophosphamide results in decreased expression of BCL6 mRNA
Cyclophosphamide metabolite results in decreased expression of BCL6 mRNA		 CTD PMID:21041162 PMID:24356939 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075 		JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 affects response to substance ISO BDH1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr11:72,577,547...72,619,435
Ensembl chr11:72,578,533...72,614,176 		JBrowse link
G Bdkrb1 bradykinin receptor B1 increases expression EXP Cyclophosphamide results in increased expression of BDKRB1 mRNA CTD PMID:10498854 PMID:15576455 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574 		JBrowse link
G Bdkrb2 bradykinin receptor B2 affects expression EXP Cyclophosphamide affects the expression of BDKRB2 mRNA CTD PMID:15576455 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Cyclophosphamide results in increased expression of BDNF mRNA CTD PMID:10683293 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Becn1 beclin 1 multiple interactions
decreases expression		 ISO BECN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of BECN1 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of BECN1 protein]		 CTD PMID:16896004 PMID:32151603 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Bik BCL2-interacting killer decreases expression ISO Cyclophosphamide results in decreased expression of BIK mRNA CTD PMID:17403535 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of BIRC3 mRNA CTD PMID:24356939 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598 		JBrowse link
G Blvrb biliverdin reductase B decreases expression EXP Cyclophosphamide results in decreased expression of BLVRB protein CTD PMID:9006340 NCBI chr 1:84,256,063...84,273,726
Ensembl chr 1:84,256,159...84,274,075 		JBrowse link
G Bpi bactericidal/permeability-increasing protein decreases expression ISO Cyclophosphamide results in decreased expression of BPI mRNA CTD PMID:17403535 NCBI chr 3:154,741,627...154,768,584
Ensembl chr 3:154,741,631...154,768,640 		JBrowse link
G Brpf1 bromodomain and PHD finger containing, 1 increases expression EXP Cyclophosphamide results in increased expression of BRPF1 mRNA CTD PMID:27281708 NCBI chr 4:145,264,445...145,280,943
Ensembl chr 4:145,264,462...145,280,857 		JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO Cyclophosphamide results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr 1:225,035,956...225,046,137
Ensembl chr 1:225,037,737...225,046,040 		JBrowse link
G Bsg basigin (Ok blood group) decreases expression ISO Cyclophosphamide results in decreased expression of BSG mRNA CTD PMID:15331540 NCBI chr 7:12,875,536...12,882,753
Ensembl chr 7:12,875,537...12,882,753 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO Cyclophosphamide results in decreased expression of BTG1 mRNA CTD PMID:21041162 NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Cyclophosphamide results in increased expression of BTG2 mRNA CTD PMID:29445054 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982 		JBrowse link
G Btg3 BTG anti-proliferation factor 3 multiple interactions ISO BTG3 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr11:16,873,642...16,889,100
Ensembl chr11:16,873,646...16,889,201 		JBrowse link
G Bub3 BUB3 mitotic checkpoint protein multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BUB3 mRNA CTD PMID:16322899 NCBI chr 1:203,526,853...203,537,459
Ensembl chr 1:203,524,426...203,557,337 		JBrowse link
G C1qa complement C1q A chain increases expression ISO Cyclophosphamide results in increased expression of C1QA mRNA CTD PMID:21041162 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143 		JBrowse link
G C3 complement C3 increases expression ISO Cyclophosphamide results in increased expression of C3 mRNA CTD PMID:21041162 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167 		JBrowse link
G Ca12 carbonic anhydrase 12 multiple interactions ISO CA12 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240 		JBrowse link
G Cabp1 calcium binding protein 1 decreases expression EXP Cyclophosphamide results in decreased expression of CABP1 mRNA CTD PMID:11906922 NCBI chr12:47,185,449...47,209,785
Ensembl chr12:47,179,664...47,209,784 		JBrowse link
G Cabp2 calcium binding protein 2 decreases expression EXP Cyclophosphamide results in decreased expression of CABP2 mRNA CTD PMID:11906922 NCBI chr 1:219,329,186...219,335,046
Ensembl chr 1:219,329,574...219,335,043 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases expression
multiple interactions		 ISO Cyclophosphamide results in increased expression of CACNA1H protein
3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein		 CTD PMID:29129814 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617 		JBrowse link
G Calr calreticulin increases expression
decreases expression		 EXP Cyclophosphamide results in increased expression of CALR mRNA
Cyclophosphamide results in decreased expression of CALR mRNA		 CTD PMID:11599041 PMID:11906922 PMID:18246545 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666 		JBrowse link
G Canx calnexin decreases expression EXP Cyclophosphamide results in decreased expression of CANX mRNA CTD PMID:11906922 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861 		JBrowse link
G Capn2 calpain 2 increases expression ISO Cyclophosphamide results in increased expression of CAPN2 mRNA CTD PMID:21041162 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811 		JBrowse link
G Car2 carbonic anhydrase 2 decreases expression
increases expression		 ISO Cyclophosphamide results in decreased expression of CA2 mRNA
Cyclophosphamide results in increased expression of CAR2 mRNA		 CTD PMID:15331540 PMID:17403535 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G Car7 carbonic anhydrase 7 decreases expression EXP Cyclophosphamide results in decreased expression of CAR7 mRNA CTD PMID:27281708 NCBI chr19:636,545...645,935
Ensembl chr19:636,545...645,937 		JBrowse link
G Cars cysteinyl-tRNA synthetase decreases expression ISO Cyclophosphamide metabolite results in decreased expression of CARS1 mRNA CTD PMID:24356939 NCBI chr 1:216,759,367...216,801,652
Ensembl chr 1:216,759,366...216,801,656 		JBrowse link
G Casp1 caspase 1 decreases expression
increases expression		 ISO Cyclophosphamide results in decreased expression of CASP1 mRNA
Cyclophosphamide results in increased expression of CASP1 mRNA		 CTD PMID:17403535 PMID:21041162 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
decreases response to substance		 ISO
EXP		 [Bortezomib co-treated with oblimersen co-treated with Cyclophosphamide] results in increased activity of CASP3 protein; BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]; Cyclophosphamide results in increased cleavage of and results in increased activity of CASP3 protein
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]
Cyclophosphamide results in increased expression of CASP3 protein
ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 protein]
Cyclophosphamide results in increased expression of CASP3 mRNA
CASP3 protein alternative form results in decreased susceptibility to Cyclophosphamide		 CTD PMID:11723234 PMID:14503796 PMID:16675587 PMID:17020986 PMID:17898787 PMID:30506662 PMID:32197949 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp4 caspase 4 increases cleavage
multiple interactions		 EXP Cyclophosphamide results in increased cleavage of CASP4 protein
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP4 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP4 protein]		 CTD PMID:32197949 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases response to substance		 ISO [Methotrexate results in increased expression of CASP8 protein] which results in increased susceptibility to Cyclophosphamide metabolite; Cyclophosphamide metabolite results in increased expression of and results in increased cleavage of CASP8 protein; Cyclophosphamide results in increased cleavage of and results in increased activity of CASP8 protein
CASP8 protein results in increased susceptibility to Cyclophosphamide metabolite		 CTD PMID:17898787 PMID:22010212 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity		 ISO
EXP		 BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP9 protein]; Cyclophosphamide results in increased cleavage of and results in increased activity of CASP9 protein
ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of CASP9 protein]		 CTD PMID:11723234 PMID:17898787 PMID:30506662 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase decreases expression
decreases activity
affects activity
multiple interactions		 EXP
ISO		 Cyclophosphamide results in decreased expression of CAT protein
Cyclophosphamide results in decreased activity of CAT protein
Cyclophosphamide results in decreased expression of CAT mRNA; Cyclophosphamide results in decreased expression of CAT protein
Cyclophosphamide affects the activity of CAT protein
Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of CAT protein]; cinnamic acid inhibits the reaction [Cyclophosphamide affects the activity of CAT protein]; Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of CAT protein]; Eicosapentaenoic Acid inhibits the reaction [Cyclophosphamide affects the activity of CAT protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of CAT protein]]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of CAT mRNA]
mangiferin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; Pentoxifylline inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; pimagedine inhibits the reaction [Cyclophosphamide results in decreased expression of CAT protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]		 CTD PMID:16076520 PMID:19107871 PMID:20052769 PMID:20957680 PMID:21772021 PMID:22285266 PMID:23542512 PMID:23695977 PMID:25753322 PMID:27633142 PMID:29753871 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccin calicin increases expression ISO Cyclophosphamide results in increased expression of CCIN protein CTD PMID:17475930 NCBI chr 5:59,452,348...59,454,235
Ensembl chr 5:59,452,348...59,454,233 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
increases expression		 EXP
ISO		 Cyclophosphamide results in decreased expression of CCL2 protein
Cyclophosphamide results in increased expression of CCL2 mRNA		 CTD PMID:18848347 PMID:21068404 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl25 C-C motif chemokine ligand 25 decreases expression ISO Cyclophosphamide results in decreased expression of CCL25 mRNA CTD PMID:21041162 NCBI chr12:2,429,492...2,438,928
Ensembl chr12:2,429,509...2,438,817 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Cyclophosphamide results in decreased expression of CCL3 protein CTD PMID:21880982 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO Cyclophosphamide results in increased expression of CCL7 mRNA CTD PMID:15331540 PMID:21041162 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Cyclophosphamide results in decreased expression of CCNA2 mRNA CTD PMID:21041162 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnd2 cyclin D2 increases expression ISO Cyclophosphamide results in increased expression of CCND2 mRNA CTD PMID:21041162 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207 		JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Cyclophosphamide results in decreased expression of CCND3 mRNA CTD PMID:21041162 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Cyclophosphamide results in increased expression of CCR5 mRNA CTD PMID:15331540 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614 		JBrowse link
G Ccr8 C-C motif chemokine receptor 8 decreases expression ISO Cyclophosphamide results in decreased expression of CCR8 mRNA CTD PMID:17403535 NCBI chr 8:128,779,552...128,782,531
Ensembl chr 8:128,781,395...128,782,456 		JBrowse link
G Ccr9 C-C motif chemokine receptor 9 decreases expression ISO Cyclophosphamide results in decreased expression of CCR9 mRNA CTD PMID:21041162 NCBI chr 8:132,827,325...132,842,130
Ensembl chr 8:132,828,091...132,842,130 		JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 decreases expression EXP Cyclophosphamide results in decreased expression of CCT3 mRNA CTD PMID:11906922 NCBI chr 2:187,669,051...187,693,610
Ensembl chr 2:187,668,796...187,693,610 		JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 decreases expression EXP Cyclophosphamide results in decreased expression of CCT5 mRNA CTD PMID:11906922 NCBI chr 2:84,667,578...84,678,730
Ensembl chr 2:84,667,633...84,678,790 		JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 decreases expression EXP Cyclophosphamide results in decreased expression of CCT7 mRNA CTD PMID:11906922 NCBI chr 4:117,235,023...117,252,265
Ensembl chr 4:117,235,023...117,252,265 		JBrowse link
G Cd14 CD14 molecule increases expression ISO Cyclophosphamide results in increased expression of CD14 mRNA CTD PMID:15331540 PMID:21041162 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153 		JBrowse link
G Cd151 CD151 molecule (Raph blood group) increases expression ISO Cyclophosphamide results in increased expression of CD151 mRNA CTD PMID:21041162 NCBI chr 1:214,446,659...214,450,668
Ensembl chr 1:214,009,784...214,013,765
Ensembl chr 1:214,009,784...214,013,765 		JBrowse link
G Cd2 Cd2 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD2 mRNA CTD PMID:21041162 NCBI chr 2:203,666,706...203,680,073
Ensembl chr 2:203,666,637...203,680,083 		JBrowse link
G Cd27 CD27 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD27 mRNA CTD PMID:21041162 NCBI chr 4:157,744,881...157,751,609
Ensembl chr 4:157,744,882...157,750,088 		JBrowse link
G Cd28 Cd28 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD28 mRNA CTD PMID:21041162 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871 		JBrowse link
G Cd38 CD38 molecule increases expression ISO Cyclophosphamide results in increased expression of CD38 mRNA CTD PMID:21041162 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672 		JBrowse link
G Cd3d CD3d molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD3D mRNA CTD PMID:21041162 NCBI chr 8:49,282,502...49,287,095
Ensembl chr 8:49,282,460...49,287,110 		JBrowse link
G Cd3e CD3e molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD3E mRNA CTD PMID:21041162 NCBI chr 8:49,297,604...49,309,370
Ensembl chr 8:49,297,608...49,308,806 		JBrowse link
G Cd3g CD3g molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD3G mRNA CTD PMID:21041162 NCBI chr 8:49,274,553...49,280,943
Ensembl chr 8:49,274,960...49,280,901 		JBrowse link
G Cd4 Cd4 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD4 mRNA CTD PMID:21041162 NCBI chr 4:157,381,862...157,408,357
Ensembl chr 4:157,383,052...157,408,176 		JBrowse link
G Cd40 CD40 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD40 mRNA CTD PMID:21041162 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704 		JBrowse link
G Cd5 Cd5 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD5 mRNA CTD PMID:21041162 NCBI chr 1:226,770,912...226,791,861
Ensembl chr 1:226,770,744...226,791,879 		JBrowse link
G Cd6 Cd6 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD6 mRNA CTD PMID:21041162 NCBI chr 1:226,848,399...226,887,259
Ensembl chr 1:226,848,403...226,887,156 		JBrowse link
G Cd69 Cd69 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD69 mRNA
Cyclophosphamide metabolite results in decreased expression of CD69 mRNA		 CTD PMID:21041162 PMID:24356939 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084 		JBrowse link
G Cd74 CD74 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD74 mRNA CTD PMID:15331540 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849 		JBrowse link
G Cd79b CD79b molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD79B mRNA CTD PMID:15331540 NCBI chr10:94,497,445...94,500,591
Ensembl chr10:94,497,448...94,500,591 		JBrowse link
G Cd83 CD83 molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD83 mRNA CTD PMID:15331540 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790 		JBrowse link
G Cd84 CD84 molecule increases expression ISO Cyclophosphamide metabolite results in increased expression of CD84 mRNA CTD PMID:24356939 NCBI chr13:90,241,369...90,283,625
Ensembl chr13:90,244,681...90,277,865 		JBrowse link
G Cd8a CD8a molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD8A mRNA CTD PMID:21041162 NCBI chr 4:99,217,640...99,243,352
Ensembl chr 4:99,239,115...99,243,351 		JBrowse link
G Cd8b CD8b molecule decreases expression ISO Cyclophosphamide results in decreased expression of CD8B1 mRNA CTD PMID:21041162 NCBI chr 4:99,185,960...99,201,887
Ensembl chr 4:99,185,885...99,202,023 		JBrowse link
G Cdc20 cell division cycle 20 increases expression EXP Cyclophosphamide results in increased expression of CDC20 mRNA CTD PMID:11599041 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015 		JBrowse link
G Cdh1 cadherin 1 affects expression EXP Cyclophosphamide affects the expression of CDH1 mRNA CTD PMID:10859244 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdh2 cadherin 2 affects expression EXP Cyclophosphamide affects the expression of CDH2 mRNA CTD PMID:10859244 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684 		JBrowse link
G Cdh3 cadherin 3 affects expression EXP Cyclophosphamide affects the expression of CDH3 mRNA CTD PMID:10859244 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Cyclophosphamide results in decreased expression of CDK2 mRNA CTD PMID:21041162 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Cyclophosphamide results in increased expression of CDKN1A mRNA CTD PMID:15331540 PMID:21527772 PMID:29445054 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of CDKN1B mRNA CTD PMID:16322899 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO Cyclophosphamide results in increased expression of CDKN1C mRNA CTD PMID:21041162 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Cyclophosphamide metabolite results in decreased expression of CEBPB mRNA CTD PMID:24356939 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910 		JBrowse link
G Cel carboxyl ester lipase increases expression ISO Cyclophosphamide results in increased expression of CEL mRNA CTD PMID:21527772 NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522 		JBrowse link
G Cfb complement factor B increases expression ISO Cyclophosphamide results in increased expression of CFB mRNA CTD PMID:21041162 NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066
Ensembl chr20:4,536,203...4,561,066 		JBrowse link
G Cfi complement factor I affects response to substance ISO CFI protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 2:235,264,149...235,305,779
Ensembl chr 2:235,264,219...235,305,781 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of CHAC1 mRNA; Cyclophosphamide results in decreased expression of CHAC1 mRNA CTD PMID:23824090 PMID:24356939 NCBI chr 3:111,160,205...111,163,425
Ensembl chr 3:111,160,205...111,163,425 		JBrowse link
G Champ1 chromosome alignment maintaining phosphoprotein 1 increases expression EXP Cyclophosphamide results in increased expression of CHAMP1 mRNA CTD PMID:27281708 NCBI chr16:80,839,373...80,850,340
Ensembl chr16:80,839,374...80,850,340 		JBrowse link
G Chd5 chromodomain helicase DNA binding protein 5 decreases expression EXP Cyclophosphamide results in decreased expression of CHD5 mRNA CTD PMID:27281708 NCBI chr 5:169,519,212...169,572,059
Ensembl chr 5:169,519,212...169,567,107 		JBrowse link
G Chga chromogranin A decreases expression ISO Cyclophosphamide results in decreased expression of CHGA mRNA CTD PMID:15331540 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 increases expression EXP Cyclophosphamide results in increased expression of CHRM5 protein CTD PMID:16125470 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 affects expression
decreases expression		 EXP Cyclophosphamide affects the expression of CITED2 mRNA
Cyclophosphamide results in decreased expression of CITED2 mRNA		 CTD PMID:18246545 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786 		JBrowse link
G Cldn1 claudin 1 multiple interactions
decreases expression		 ISO Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN1 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN1 protein] CTD PMID:32151603 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416 		JBrowse link
G Cldn4 claudin 4 multiple interactions
decreases expression		 EXP Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN4 protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN4 protein] CTD PMID:25451569 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005 		JBrowse link
G Clic4 chloride intracellular channel 4 increases expression ISO Cyclophosphamide results in increased expression of CLIC4 mRNA CTD PMID:15331540 NCBI chr 5:153,568,937...153,625,669
Ensembl chr 5:153,568,745...153,625,869 		JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 decreases expression EXP Cyclophosphamide results in decreased expression of CLIP1 mRNA CTD PMID:27281708 NCBI chr12:38,345,203...38,452,650
Ensembl chr12:38,345,456...38,452,652 		JBrowse link
G Coch cochlin affects response to substance ISO COCH protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 6:72,359,702...72,373,710
Ensembl chr 6:72,359,791...72,373,695 		JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Cyclophosphamide results in increased expression of COMT mRNA CTD PMID:21041162 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622 		JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 decreases expression ISO Cyclophosphamide results in decreased expression of COX7A2 mRNA CTD PMID:17403535 NCBI chr 8:87,209,529...87,213,627
Ensembl chr 8:87,209,530...87,213,627 		JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 increases expression ISO Cyclophosphamide results in increased expression of CRABP2 mRNA CTD PMID:21527772 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression ISO Cyclophosphamide results in increased expression of CREB1 protein modified form CTD PMID:18299998 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Crem cAMP responsive element modulator decreases expression
multiple interactions		 EXP Cyclophosphamide results in decreased expression of CREM mRNA; Cyclophosphamide results in decreased expression of CREM protein
Drugs, Chinese Herbal inhibits the reaction [Cyclophosphamide results in decreased expression of CREM mRNA]; Drugs, Chinese Herbal inhibits the reaction [Cyclophosphamide results in decreased expression of CREM protein]		 CTD PMID:17624719 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888 		JBrowse link
G Crh corticotropin releasing hormone increases expression EXP
ISO		 Cyclophosphamide results in increased expression of CRH mRNA; Cyclophosphamide results in increased expression of CRH protein CTD PMID:15276878 PMID:16614059 PMID:17335920 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 increases expression EXP Cyclophosphamide results in increased expression of CRHR2 protein CTD PMID:16614059 NCBI chr 4:85,286,371...85,329,374
Ensembl chr 4:85,286,372...85,329,362 		JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO [Cyclophosphamide co-treated with Sizofiran] results in increased expression of CSF1 mRNA CTD PMID:10052129 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560 		JBrowse link
G Csf2 colony stimulating factor 2 affects activity
increases expression		 ISO
EXP		 CSF2 protein affects the activity of Cyclophosphamide
Cyclophosphamide results in increased expression of CSF2 protein		 CTD PMID:8349185 PMID:18848347 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Csk C-terminal Src kinase decreases expression ISO Cyclophosphamide results in decreased expression of CSK mRNA CTD PMID:21041162 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303 		JBrowse link
G Cst7 cystatin F decreases expression ISO Cyclophosphamide results in decreased expression of CST7 mRNA CTD PMID:17403535 NCBI chr 3:146,363,913...146,373,365
Ensembl chr 3:146,365,092...146,373,365 		JBrowse link
G Csta cystatin A decreases expression ISO Cyclophosphamide metabolite results in decreased expression of CSTA mRNA CTD PMID:24356939 NCBI chr11:67,555,792...67,566,980
Ensembl chr11:67,555,658...67,566,972 		JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO Cyclophosphamide results in increased expression of CTH protein CTD PMID:29129814 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046 		JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of CTNNBIP1 mRNA CTD PMID:16322899 NCBI chr 5:166,464,170...166,513,030
Ensembl chr 5:166,464,252...166,513,027 		JBrowse link
G Ctnnd2 catenin delta 2 multiple interactions ISO CTNND2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 2:83,227,247...84,094,315
Ensembl chr 2:83,393,282...84,094,315 		JBrowse link
G Ctsd cathepsin D multiple interactions
increases activity		 ISO
EXP		 [Cyclophosphamide co-treated with Mecamylamine] results in increased expression of CTSD mRNA
Cyclophosphamide results in increased activity of CTSD protein
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of CTSD protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in increased activity of CTSD protein]		 CTD PMID:18433785 PMID:25451569 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451 		JBrowse link
G Ctsh cathepsin H increases expression ISO Cyclophosphamide results in increased expression of CTSH mRNA CTD PMID:17403535 NCBI chr 8:97,439,155...97,458,293
Ensembl chr 8:97,439,161...97,458,287 		JBrowse link
G Ctsl cathepsin L increases expression
decreases expression
multiple interactions		 ISO Cyclophosphamide results in increased expression of CTSL mRNA
Cyclophosphamide results in decreased expression of CTSL mRNA
5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline inhibits the reaction [Cyclophosphamide results in decreased expression of CTSL mRNA]		 CTD PMID:17403535 PMID:30760223 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression EXP Cyclophosphamide results in increased expression of CX3CL1 protein CTD PMID:16651033 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 increases expression EXP Cyclophosphamide results in increased expression of CX3CR1 protein CTD PMID:16651033 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Cyclophosphamide results in increased expression of CXCL1 protein CTD PMID:18848347 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 affects expression
increases expression
increases response to substance		 ISO Cyclophosphamide affects the expression of CXCL10 mRNA
Cyclophosphamide results in increased expression of CXCL10 protein
CXCL10 protein results in increased susceptibility to Cyclophosphamide		 CTD PMID:18957084 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO Cyclophosphamide results in increased expression of CXCL11 protein CTD PMID:18957084 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 affects expression
increases expression		 ISO
EXP		 Cyclophosphamide affects the expression of CXCL12 mRNA
Cyclophosphamide results in increased expression of CXCL12 mRNA; Cyclophosphamide results in increased expression of CXCL12 protein		 CTD PMID:12624490 PMID:16337237 PMID:19066630 PMID:20032115 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
affects expression
multiple interactions		 ISO Cyclophosphamide results in increased expression of CXCL1 mRNA; Cyclophosphamide results in increased expression of CXCL1 protein
Cyclophosphamide affects the expression of CXCL3 mRNA
VIP protein inhibits the reaction [Cyclophosphamide results in increased expression of CXCL1 protein]		 CTD PMID:15331540 PMID:18483878 PMID:18957084 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO Cyclophosphamide results in increased expression of CXCL5 mRNA CTD PMID:15331540 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 affects expression
decreases expression
increases expression		 ISO Cyclophosphamide affects the expression of CXCL9 mRNA
Cyclophosphamide results in decreased expression of CXCL9 protein
Cyclophosphamide results in increased expression of CXCL9 mRNA; Cyclophosphamide results in increased expression of CXCL9 protein		 CTD PMID:15331540 PMID:18957084 PMID:21041162 PMID:21880982 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions
decreases expression
increases expression
affects localization		 EXP
ISO		 Cyclophosphamide promotes the reaction [MIF protein binds to CXCR4 protein]
Cyclophosphamide results in decreased expression of CXCR4 mRNA
Cyclophosphamide results in increased expression of CXCR4 mRNA; Cyclophosphamide results in increased expression of CXCR4 protein
Cyclophosphamide affects the localization of CXCR4 protein		 CTD PMID:19066630 PMID:20032115 PMID:21041162 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878 		JBrowse link
G Cxcr6 C-X-C motif chemokine receptor 6 increases expression ISO Cyclophosphamide results in increased expression of CXCR6 mRNA CTD PMID:21041162 NCBI chr 8:132,869,712...132,870,766
Ensembl chr 8:132,869,712...132,870,767 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Cyclophosphamide results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Cyclophosphamide results in decreased activity of CYP1A2 protein CTD PMID:18420780 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO Cyclophosphamide results in decreased expression of CYP1B1 mRNA CTD PMID:12167460 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
increases response to substance
affects metabolic processing
increases activity
increases hydroxylation
increases metabolic processing		 EXP
ISO		 Cyclophosphamide results in increased expression of and results in increased activity of CYP2B1 protein; Metyrapone inhibits the reaction [CYP2B1 results in increased susceptibility to Cyclophosphamide]
Cyclophosphamide results in increased expression of CYP2B10 mRNA
CYP2B1 protein results in increased susceptibility to Cyclophosphamide; CYP2B1 results in increased susceptibility to Cyclophosphamide
CYP2B1 protein affects the metabolism of Cyclophosphamide
CYP2B1 results in increased activity of Cyclophosphamide
CYP2B1 protein mutant form results in increased hydroxylation of Cyclophosphamide; CYP2B1 protein results in increased hydroxylation of Cyclophosphamide
Cyclophosphamide results in increased expression of CYP2B1 mRNA; Cyclophosphamide results in increased expression of CYP2B1 protein
CYP2B1 protein results in increased metabolism of Cyclophosphamide; CYP2B1 results in increased metabolism of Cyclophosphamide		 CTD PMID:2272335 PMID:7834628 PMID:8640822 PMID:9592392 PMID:10415877 PMID:11221871 PMID:11933215 PMID:15102956 PMID:15635577 PMID:16019949 PMID:17634551 PMID:19103281 PMID:20566340 PMID:24819615 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Cyclophosphamide results in increased expression of CYP2B2 mRNA; Cyclophosphamide results in increased expression of CYP2B2 protein CTD PMID:16019949 PMID:17634551 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases metabolic processing
increases activity
increases response to substance
increases hydroxylation
affects hydroxylation		 ISO
EXP		 [Cyclophosphamide results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; [Doxorubicin co-treated with Cyclophosphamide] affects the expression of CYP2B6 mRNA; Cyclophosphamide results in decreased expression of and results in decreased activity of CYP2B6 protein; CYP2B6 protein polymorphism affects the activity of and affects the susceptibility to Cyclophosphamide; CYP2B6 protein results in increased metabolism of and results in increased susceptibility to Cyclophosphamide; POR promotes the reaction [CYP2B6 results in increased susceptibility to Cyclophosphamide]; POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to Cyclophosphamide]
CYP2B6 protein results in increased metabolism of Cyclophosphamide
CYP2B6 protein results in increased activity of Cyclophosphamide
CYP2B6 protein results in increased susceptibility to Cyclophosphamide; CYP2B6 results in increased susceptibility to Cyclophosphamide
CYP2B6 protein results in increased hydroxylation of Cyclophosphamide
CYP2B6 intron polymorphism affects the hydroxylation of Cyclophosphamide; CYP2B6 promoter polymorphism affects the hydroxylation of Cyclophosphamide		 CTD PMID:9766669 PMID:10919648 PMID:11389073 PMID:11723234 PMID:12498089 PMID:12872138 PMID:15248218 PMID:15769884 PMID:16183265 PMID:16322899 PMID:17041008 PMID:17502835 PMID:18212249 PMID:18633247 PMID:24819615 PMID:25860621 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression
increases metabolic processing
increases response to substance
increases activity
multiple interactions		 EXP
ISO		 Cyclophosphamide results in increased expression of CYP2C11 mRNA
CYP2C9 protein results in increased metabolism of Cyclophosphamide
CYP2C9 protein results in increased susceptibility to Cyclophosphamide
CYP2C9 results in increased activity of Cyclophosphamide
[GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased susceptibility to Cyclophosphamide]
CYP2C11 results in increased metabolism of Cyclophosphamide		 CTD PMID:9241661 PMID:10991840 PMID:11377097 PMID:16019949 PMID:20566340 PMID:24819615 PMID:28744217 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions
increases response to substance
increases activity		 ISO POR promotes the reaction [CYP2C18 results in increased susceptibility to Cyclophosphamide]
CYP2C18 results in increased activity of Cyclophosphamide		 CTD PMID:9241661 PMID:9766669 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing
increases response to substance
increases hydroxylation
increases activity
multiple interactions
decreases metabolic processing		 EXP
ISO		 CYP2C6V1 results in increased metabolism of Cyclophosphamide
CYP2C19 protein results in increased susceptibility to Cyclophosphamide
CYP2C19 protein results in increased hydroxylation of Cyclophosphamide
CYP2C19 results in increased activity of Cyclophosphamide
CYP2C19 protein results in increased metabolism of Cyclophosphamide
[CYP2C19 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of 4-hydroxycyclophosphamide; [CYP2C19 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of Acrolein; CYP2C19 protein polymorphism affects the activity of and affects the susceptibility to Cyclophosphamide
CYP2C19 gene polymorphism results in decreased metabolism of Cyclophosphamide		 CTD PMID:9241661 PMID:15248218 PMID:16116487 PMID:20566340 PMID:30500380 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases activity
increases expression		 ISO CYP2C8 results in increased activity of Cyclophosphamide
Cyclophosphamide results in increased expression of CYP2C29 mRNA		 CTD PMID:9241661 PMID:24819615 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of Cyclophosphamide CTD PMID:11377097 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing EXP CYP2E1 results in increased metabolism of Cyclophosphamide CTD PMID:20566340 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP Cyclophosphamide results in increased expression of CYP3A2 mRNA; Cyclophosphamide results in increased expression of CYP3A2 protein CTD PMID:16019949 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects expression
decreases expression		 EXP Cyclophosphamide affects the expression of CYP3A23-3A1 mRNA
Cyclophosphamide results in decreased expression of CYP3A23-3A1 mRNA		 CTD PMID:18246545 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases metabolic processing
decreases activity
affects response to substance
increases expression
affects metabolic processing
increases response to substance
multiple interactions
increases hydroxylation		 ISO CYP3A4 protein results in increased metabolism of Cyclophosphamide
Cyclophosphamide results in decreased activity of CYP3A4 protein
CYP3A4 gene polymorphism affects the susceptibility to Cyclophosphamide
Cyclophosphamide results in increased expression of CYP3A4 mRNA
CYP3A4 protein affects the metabolism of Cyclophosphamide
CYP3A4 protein results in increased susceptibility to Cyclophosphamide
[Cyclophosphamide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [CYP3A4 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of 4-hydroxycyclophosphamide; [CYP3A4 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of Acrolein; CYP3A4 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin]; CYP3A4 protein results in increased metabolism of and results in increased susceptibility to Cyclophosphamide		 CTD PMID:11377097 PMID:16087946 PMID:17041008 PMID:18420780 PMID:18839173 PMID:25860621 PMID:26718876 PMID:30500380 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing
increases expression
multiple interactions
affects response to substance		 ISO CYP3A5 protein affects the metabolism of Cyclophosphamide
Cyclophosphamide results in increased expression of CYP3A13 mRNA
CYP3A5 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin]
CYP3A5 gene polymorphism affects the susceptibility to Cyclophosphamide		 CTD PMID:16087946 PMID:24819615 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Dcn decorin multiple interactions ISO DCN protein inhibits the reaction [TGFB1 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Cisplatin co-treated with Melphalan co-treated with Thiotepa]] CTD PMID:9509296 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323 		JBrowse link
G Ddb1 damage-specific DNA binding protein 1 increases expression EXP Cyclophosphamide results in increased expression of DDB1 mRNA CTD PMID:11056294 NCBI chr 1:226,657,561...226,683,356
Ensembl chr 1:226,657,561...226,683,347 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression
increases expression
multiple interactions
decreases expression		 EXP
ISO		 Cyclophosphamide affects the expression of DDIT3 mRNA
Cyclophosphamide results in increased expression of DDIT3 mRNA; Cyclophosphamide results in increased expression of DDIT3 protein
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 mRNA]; sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 protein]
Cyclophosphamide metabolite results in decreased expression of DDIT3 mRNA		 CTD PMID:18246545 PMID:24356939 PMID:32197949 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 affects response to substance ISO DDIT4 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382 		JBrowse link
G Deaf1 DEAF1 transcription factor decreases expression EXP Cyclophosphamide results in decreased expression of DEAF1 mRNA CTD PMID:27281708 NCBI chr 1:214,283,787...214,317,466
Ensembl chr 1:214,283,790...214,317,466 		JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein increases expression ISO Cyclophosphamide results in increased expression of DLC1 mRNA CTD PMID:17403535 NCBI chr16:58,776,489...59,247,752
Ensembl chr16:59,077,574...59,247,754 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 affects expression
increases expression		 EXP
ISO		 Cyclophosphamide affects the expression of DNAJB1 mRNA
Cyclophosphamide metabolite results in increased expression of DNAJB1 mRNA		 CTD PMID:18246545 PMID:24356939 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Cyclophosphamide metabolite results in increased expression of DNAJB4 mRNA CTD PMID:24356939 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242 		JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 increases expression ISO Cyclophosphamide results in increased expression of DNAJB6 protein CTD PMID:17475930 NCBI chr 4:2,711,329...2,774,969
Ensembl chr 4:2,711,385...2,774,890 		JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions
increases expression
decreases methylation		 ISO Cyclophosphamide promotes the reaction [KDM1A protein results in decreased methylation of and results in decreased degradation of DNMT1 protein]
Cyclophosphamide results in increased expression of DNMT1 protein
Cyclophosphamide results in decreased methylation of DNMT1 protein		 CTD PMID:22007908 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495 		JBrowse link
G Dntt DNA nucleotidylexotransferase decreases expression ISO Cyclophosphamide results in decreased expression of DNTT mRNA CTD PMID:21041162 NCBI chr 1:260,289,626...260,321,174
Ensembl chr 1:260,289,589...260,321,320 		JBrowse link
G Dpf3 double PHD fingers 3 decreases expression EXP Cyclophosphamide results in decreased expression of DPF3 mRNA CTD PMID:27281708 NCBI chr 6:106,660,569...106,971,310
Ensembl chr 6:106,721,349...106,971,250 		JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 increases expression ISO Cyclophosphamide results in increased expression of DPYSL4 mRNA CTD PMID:21527772 NCBI chr 1:211,423,022...211,438,533
Ensembl chr 1:211,423,022...211,438,531 		JBrowse link
G Drd1 dopamine receptor D1 affects binding ISO Cyclophosphamide binds to DRD1 protein CTD PMID:11180191 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541 		JBrowse link
G Drd2 dopamine receptor D2 affects binding ISO Cyclophosphamide binds to DRD2 protein CTD PMID:11180191 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Dusp10 dual specificity phosphatase 10 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of DUSP10 mRNA CTD PMID:24356939 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455 		JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression ISO Cyclophosphamide results in decreased expression of DUSP2 mRNA CTD PMID:21041162 NCBI chr 3:119,776,925...119,779,110
Ensembl chr 3:119,776,925...119,779,099 		JBrowse link
G Dzip1 DAZ interacting zinc finger protein 1 increases expression ISO Cyclophosphamide results in increased expression of DZIP1 mRNA CTD PMID:17403535 NCBI chr15:104,117,551...104,168,574
Ensembl chr15:104,117,556...104,170,958 		JBrowse link
G E2f3 E2F transcription factor 3 multiple interactions ISO E2F3 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831 		JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO Cyclophosphamide results in increased expression of EDA2R mRNA CTD PMID:21527772 NCBI chr  X:66,560,200...66,602,509
Ensembl chr  X:66,561,286...66,602,506 		JBrowse link
G Edn1 endothelin 1 increases expression ISO Cyclophosphamide results in increased expression of EDN1 protein CTD PMID:17562616 PMID:18548196 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Ednrb endothelin receptor type B increases expression ISO Cyclophosphamide results in increased expression of EDNRB mRNA CTD PMID:20849824 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression EXP Cyclophosphamide results in decreased expression of EEF2 mRNA CTD PMID:18246545 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR protein affects the susceptibility to [Cyclophosphamide co-treated with Doxorubicin co-treated with Fluorouracil] CTD PMID:15981280 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
decreases expression		 ISO
EXP		 Cyclophosphamide results in increased expression of EGR1 mRNA
3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein
Cyclophosphamide results in increased expression of EGR1 protein
Cyclophosphamide results in decreased expression of EGR1 mRNA		 CTD PMID:7498375 PMID:9776515 PMID:21041162 PMID:21527772 PMID:29129814 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Egr2 early growth response 2 decreases expression ISO Cyclophosphamide results in decreased expression of EGR2 mRNA CTD PMID:21041162 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025 		JBrowse link
G Egr4 early growth response 4 decreases expression EXP Cyclophosphamide results in decreased expression of EGR4 mRNA CTD PMID:27281708 NCBI chr 4:117,293,620...117,296,082
Ensembl chr 4:117,293,620...117,296,082 		JBrowse link
G Eif1ax eukaryotic translation initiation factor 1A, X-linked multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of EIF1AX mRNA CTD PMID:16322899 NCBI chr  X:37,579,959...37,595,300
Ensembl chr  X:37,579,957...37,595,486 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
multiple interactions		 EXP Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein]		 CTD PMID:32197949 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of EIF4EBP1 mRNA CTD PMID:16322899 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248 		JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 affects response to substance ISO ELOVL2 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr17:21,382,461...21,422,413
Ensembl chr17:21,382,455...21,422,407 		JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Cyclophosphamide results in increased expression of EMP1 mRNA CTD PMID:21527772 NCBI chr 4:169,161,076...169,181,967
Ensembl chr 4:169,147,243...169,181,966 		JBrowse link
G Emp3 epithelial membrane protein 3 increases expression ISO Cyclophosphamide results in increased expression of EMP3 mRNA CTD PMID:21527772 NCBI chr 1:101,900,731...101,903,948
Ensembl chr 1:101,900,733...101,903,910 		JBrowse link
G Epb41l2 erythrocyte membrane protein band 4.1-like 2 decreases expression ISO Cyclophosphamide results in decreased expression of EPB41L2 mRNA CTD PMID:17403535 NCBI chr 1:20,881,820...21,067,713
Ensembl chr 1:20,893,995...20,962,526 		JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression
increases expression		 EXP Cyclophosphamide affects the expression of EPHX1 mRNA
Cyclophosphamide results in increased expression of EPHX1 mRNA		 CTD PMID:18246545 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G Epo erythropoietin multiple interactions
increases response to substance
decreases expression		 EXP angelicae sinensis extract inhibits the reaction [Cyclophosphamide results in decreased expression of EPO mRNA]; Astragali compound inhibits the reaction [Cyclophosphamide results in decreased expression of EPO mRNA]
EPO protein results in increased susceptibility to Cyclophosphamide		 CTD PMID:11245434 PMID:19627214 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266 		JBrowse link
G Erap1 endoplasmic reticulum aminopeptidase 1 increases expression EXP Cyclophosphamide results in increased expression of ERAP1 mRNA CTD PMID:27281708 NCBI chr 2:1,410,877...1,449,734
Ensembl chr 2:1,410,934...1,449,733 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO ERBB2 affects the susceptibility to [Doxorubicin co-treated with Cyclophosphamide co-treated with docetaxel]; ERBB2 protein affects the susceptibility to [Cyclophosphamide co-treated with Doxorubicin co-treated with docetaxel]; ERBB2 protein affects the susceptibility to [Cyclophosphamide co-treated with pirarubicin co-treated with Fluorouracil]; ERBB2 protein affects the susceptibility to [Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]; ERBB2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; ERBB2 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Thiotepa co-treated with Carboplatin] CTD PMID:9816327 PMID:15834928 PMID:15940066 PMID:16446318 PMID:16682728 PMID:17010609 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO ERBB4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit affects expression EXP Cyclophosphamide affects the expression of ERCC1 mRNA CTD PMID:11906922 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit affects expression
increases expression
multiple interactions		 EXP
ISO		 Cyclophosphamide affects the expression of ERCC2 mRNA
Cyclophosphamide results in increased expression of ERCC2 mRNA
5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline inhibits the reaction [Cyclophosphamide results in increased expression of ERCC2 mRNA]		 CTD PMID:11906922 PMID:30760223 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344 		JBrowse link
G Erg ETS transcription factor ERG increases expression ISO Cyclophosphamide results in increased expression of ERG mRNA CTD PMID:17403535 NCBI chr11:35,645,317...35,749,637
Ensembl chr11:35,646,116...35,749,594 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases phosphorylation
multiple interactions		 EXP Cyclophosphamide results in increased phosphorylation of ERN1 protein
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of ERN1 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of ERN1 protein]		 CTD PMID:32197949 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] results in increased expression of ESR1 mRNA CTD PMID:16322899 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] results in increased expression of ESR2 mRNA CTD PMID:16322899 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Esrra estrogen related receptor, alpha decreases expression
increases expression		 EXP Cyclophosphamide results in decreased expression of ESRRA mRNA
Cyclophosphamide results in increased expression of ESRRA mRNA		 CTD PMID:27281708 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725 		JBrowse link
G Evi2a ecotropic viral integration site 2A decreases expression ISO Cyclophosphamide metabolite results in decreased expression of EVI2A mRNA CTD PMID:24356939 NCBI chr10:66,870,048...66,873,948
Ensembl chr10:66,870,067...66,873,948 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 increases expression EXP Cyclophosphamide results in increased expression of F2RL1 protein CTD PMID:15643279 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275 		JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 increases expression EXP Cyclophosphamide results in increased expression of F2RL2 protein CTD PMID:15643279 NCBI chr 2:26,240,385...26,245,533
Ensembl chr 2:26,240,385...26,245,533 		JBrowse link
G F2rl3 F2R like thrombin or trypsin receptor 3 increases expression EXP Cyclophosphamide results in increased expression of F2RL3 protein CTD PMID:15643279 NCBI chr16:18,817,797...18,819,790
Ensembl chr16:18,814,622...18,819,833 		JBrowse link
G F3 coagulation factor III, tissue factor decreases expression ISO Cyclophosphamide results in decreased expression of F3 mRNA CTD PMID:17403535 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Fam107b family with sequence similarity 107, member B decreases expression ISO Cyclophosphamide metabolite results in decreased expression of FAM107B mRNA CTD PMID:24356939 NCBI chr17:78,489,667...78,689,933
Ensembl chr17:78,489,668...78,561,613 		JBrowse link
G Fam234b family with sequence similarity 234, member B multiple interactions ISO FAM234B mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 4:168,976,797...169,052,750
Ensembl chr 4:168,976,859...169,019,561 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
decreases expression
increases expression		 ISO
EXP		 [Cyclophosphamide co-treated with cacalol] results in decreased expression of FAS protein; [Cyclophosphamide co-treated with NAc-Sar-Gly-Val-(d-allo-Ile)-Thr-Nva-Ile-Arg-ProNEt] results in increased expression of FAS
Plant Extracts inhibits the reaction [Cyclophosphamide results in increased expression of FAS mRNA]
Cyclophosphamide metabolite results in decreased expression of FAS mRNA
Cyclophosphamide results in increased expression of FAS mRNA; Cyclophosphamide results in increased expression of FAS protein		 CTD PMID:10393266 PMID:16166447 PMID:20665104 PMID:24356939 PMID:25446862 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [Cyclophosphamide co-treated with NAc-Sar-Gly-Val-(d-allo-Ile)-Thr-Nva-Ile-Arg-ProNEt] results in increased expression of FASLG CTD PMID:16166447 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fau FAU, ubiquitin like and ribosomal protein S30 fusion increases expression EXP Cyclophosphamide results in increased expression of FAU mRNA CTD PMID:11599041 NCBI chr 1:221,420,312...221,421,827
Ensembl chr 1:221,420,271...221,421,842 		JBrowse link
G Fbxo40 F-box protein 40 increases expression EXP Cyclophosphamide results in increased expression of FBXO40 mRNA CTD PMID:27281708 NCBI chr11:66,713,913...66,731,195
Ensembl chr11:66,713,888...66,731,198 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 increases expression ISO Cyclophosphamide results in increased expression of FBXW7 mRNA CTD PMID:29445054 NCBI chr 2:184,230,191...184,309,805
Ensembl chr 2:184,231,260...184,309,664 		JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig increases expression ISO Cyclophosphamide results in increased expression of FCER1G mRNA CTD PMID:21041162 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326 		JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa increases expression ISO Cyclophosphamide results in increased expression of FCGR3 mRNA CTD PMID:21041162 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036 		JBrowse link
G Fcgrt Fc fragment of IgG receptor and transporter increases expression ISO Cyclophosphamide results in increased expression of FCGRT mRNA CTD PMID:21041162 NCBI chr 1:101,086,872...101,096,159
Ensembl chr 1:101,086,877...101,095,594 		JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Cyclophosphamide results in increased expression of FHL1 mRNA CTD PMID:23558518 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B affects response to substance ISO FKBP1B protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451 		JBrowse link
G Fkbpl FKBP prolyl isomerase like increases expression ISO Cyclophosphamide results in increased expression of FKBPL mRNA CTD PMID:14503796 NCBI chr20:4,411,890...4,413,360
Ensembl chr20:4,411,876...4,413,366 		JBrowse link
G Flnc filamin C increases expression ISO Cyclophosphamide results in increased expression of FLNC mRNA CTD PMID:21527772 NCBI chr 4:56,710,934...56,738,779
Ensembl chr 4:56,711,049...56,738,791 		JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand affects expression ISO Cyclophosphamide affects the expression of FLT3L mRNA CTD PMID:12624490 NCBI chr 1:101,126,006...101,131,413
Ensembl chr 1:101,124,479...101,131,413 		JBrowse link
G Fndc3b fibronectin type III domain containing 3B affects response to substance ISO FNDC3B protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 2:113,109,949...113,415,171
Ensembl chr 2:113,112,902...113,345,577 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO
EXP		 Capsaicin inhibits the reaction [Cyclophosphamide results in increased expression of FOS mRNA]
Cyclophosphamide results in increased expression of FOS protein
alfuzosin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein]; Capsaicin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein]; resiniferatoxin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein]		 CTD PMID:7498375 PMID:8801120 PMID:8808730 PMID:9776515 PMID:10749792 PMID:15099680 PMID:15217452 PMID:17240043 PMID:18093676 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Foxp3 forkhead box P3 decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased expression of FOXP3 mRNA; Cyclophosphamide results in decreased expression of FOXP3 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of FOXP3 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of FOXP3 protein]		 CTD PMID:15591121 PMID:32151603 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522 		JBrowse link
G Foxp4 forkhead box P4 decreases expression EXP Cyclophosphamide results in decreased expression of FOXP4 mRNA CTD PMID:27281708 NCBI chr 9:15,068,378...15,124,962
Ensembl chr 9:15,068,399...15,125,318 		JBrowse link
G Fpr2 formyl peptide receptor 2 increases expression ISO Cyclophosphamide results in increased expression of FPR2 mRNA CTD PMID:15331540 NCBI chr 1:59,800,558...59,809,507
Ensembl chr 1:59,800,984...59,802,401 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 increases expression ISO Cyclophosphamide results in increased expression of FSCN1 mRNA CTD PMID:17403535 NCBI chr12:13,655,459...13,668,595
Ensembl chr12:13,656,554...13,668,515 		JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression
multiple interactions
decreases secretion		 ISO
EXP		 Cyclophosphamide results in increased expression of FSHB protein
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of FSHB protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of FSHB protein]		 CTD PMID:6788612 PMID:25446862 PMID:32197949 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131 		JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions
decreases expression		 ISO coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of FSHR mRNA] CTD PMID:31557371 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase increases expression ISO Cyclophosphamide results in increased expression of FYN mRNA CTD PMID:17403535 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317 		JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 decreases expression ISO Cyclophosphamide results in decreased expression of G3BP1 mRNA CTD PMID:21041162 NCBI chr10:40,812,858...40,846,252
Ensembl chr10:40,812,858...40,846,252 		JBrowse link
G G6pc2 glucose-6-phosphatase catalytic subunit 2 decreases expression ISO Cyclophosphamide results in decreased expression of G6PC2 mRNA CTD PMID:15331540 NCBI chr 3:55,464,528...55,467,170 JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression
affects expression		 EXP
ISO		 Cyclophosphamide results in increased expression of GADD45A mRNA
Cyclophosphamide affects the expression of GADD45A mRNA		 CTD PMID:18246545 PMID:29445054 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gal galanin and GMAP prepropeptide affects expression
increases expression		 EXP
ISO		 Cyclophosphamide affects the expression of GAL mRNA; Cyclophosphamide affects the expression of GAL protein
Cyclophosphamide results in increased expression of GAL mRNA		 CTD PMID:16491427 PMID:17335920 PMID:18563302 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925 		JBrowse link
G Galc galactosylceramidase affects response to substance ISO GALC protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 6:122,177,195...122,239,411
Ensembl chr 6:122,178,602...122,239,614 		JBrowse link
G Gamt guanidinoacetate N-methyltransferase multiple interactions ISO GAMT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 7:12,314,848...12,317,998
Ensembl chr 7:12,314,848...12,317,998 		JBrowse link
G Gap43 growth associated protein 43 increases expression EXP Cyclophosphamide results in increased expression of GAP43 protein CTD PMID:9486479 PMID:10536274 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914 		JBrowse link
G Gas2 growth arrest-specific 2 increases expression ISO Cyclophosphamide results in increased expression of GAS2 protein CTD PMID:17475930 NCBI chr 1:107,234,389...107,363,624
Ensembl chr 1:107,262,659...107,363,788 		JBrowse link
G Gata3 GATA binding protein 3 decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased expression of GATA3 mRNA; Cyclophosphamide results in decreased expression of GATA3 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of GATA3 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of GATA3 protein]		 CTD PMID:21041162 PMID:32151603 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681 		JBrowse link
G Gbp1 guanylate binding protein 1 increases expression ISO Cyclophosphamide results in increased expression of GBP1 mRNA CTD PMID:21621594 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570 		JBrowse link
G Gbp4 guanylate binding protein 4 increases expression ISO Cyclophosphamide results in increased expression of GBP3 mRNA CTD PMID:15331540 NCBI chr 2:248,249,232...248,263,104
Ensembl chr 2:248,249,468...248,263,168 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
decreases expression		 ISO Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of GCLC protein]
Cyclophosphamide results in decreased expression of GCLC mRNA; Cyclophosphamide results in decreased expression of GCLC protein		 CTD PMID:27633142 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression EXP Cyclophosphamide results in increased expression of GDNF mRNA CTD PMID:10683293 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238 		JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression ISO Cyclophosphamide results in increased expression of GEM mRNA CTD PMID:21041162 NCBI chr 5:25,339,479...25,353,661
Ensembl chr 5:25,349,928...25,353,661 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor decreases expression ISO Cyclophosphamide results in decreased expression of GFI1 mRNA CTD PMID:21041162 NCBI chr14:3,058,035...3,073,332
Ensembl chr14:3,058,993...3,068,371 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 multiple interactions ISO GFRA1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 1:279,203,046...279,572,789 JBrowse link
G Gimap4 GTPase, IMAP family member 4 decreases expression EXP Cyclophosphamide results in decreased expression of GIMAP4 mRNA CTD PMID:27466211 NCBI chr 4:78,320,230...78,327,144
Ensembl chr 4:78,320,190...78,327,144 		JBrowse link
G Gja1 gap junction protein, alpha 1 affects expression EXP Cyclophosphamide affects the expression of GJA1 mRNA CTD PMID:10859244 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression ISO Cyclophosphamide results in decreased expression of GJB1 mRNA CTD PMID:21621594 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977 		JBrowse link
G Glis1 GLIS family zinc finger 1 decreases expression EXP Cyclophosphamide results in decreased expression of GLIS1 mRNA CTD PMID:27281708 NCBI chr 5:127,043,344...127,233,395
Ensembl chr 5:127,160,495...127,233,078 		JBrowse link
G Glod4 glyoxalase domain containing 4 decreases expression ISO Cyclophosphamide results in decreased expression of GLOD4 mRNA CTD PMID:20849824 NCBI chr10:64,379,922...64,398,263
Ensembl chr10:64,379,921...64,398,294 		JBrowse link
G Glrb glycine receptor, beta increases expression ISO Cyclophosphamide results in increased expression of GLRB mRNA CTD PMID:17403535 NCBI chr 2:179,768,040...179,842,612
Ensembl chr 2:179,769,009...179,842,547 		JBrowse link
G Gls glutaminase increases expression
affects response to substance		 ISO Cyclophosphamide results in increased expression of GLS mRNA
GLS protein affects the susceptibility to Cyclophosphamide		 CTD PMID:16217747 PMID:21527772 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872 		JBrowse link
G Gng12 G protein subunit gamma 12 increases expression ISO Cyclophosphamide results in increased expression of GNG12 mRNA CTD PMID:17403535 NCBI chr 4:97,634,925...97,763,478
Ensembl chr 4:97,657,671...97,760,102 		JBrowse link
G Gpatch8 G patch domain containing 8 increases expression EXP Cyclophosphamide results in increased expression of GPATCH8 mRNA CTD PMID:27281708 NCBI chr10:90,421,443...90,501,996
Ensembl chr10:90,421,442...90,501,819 		JBrowse link
G Gpr137b G protein-coupled receptor 137B increases expression ISO Cyclophosphamide results in increased expression of GPR137B mRNA CTD PMID:21527772 NCBI chr17:90,670,852...90,709,003
Ensembl chr17:90,670,872...90,746,804 		JBrowse link
G Gpr18 G protein-coupled receptor 18 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of GPR18 mRNA CTD PMID:24356939 NCBI chr15:108,323,157...108,326,907
Ensembl chr15:108,323,179...108,326,907 		JBrowse link
G Gpr20 G protein-coupled receptor 20 increases expression ISO Cyclophosphamide results in increased expression of GPR20 mRNA CTD PMID:20849824 NCBI chr 7:114,943,675...114,953,977
Ensembl chr 7:114,944,282...114,945,344 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
increases activity
multiple interactions		 EXP
ISO		 Cyclophosphamide results in increased expression of GPT protein
Cyclophosphamide results in increased activity of GPT protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein]
Rutin inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein]; Vitamin E inhibits the reaction [Cyclophosphamide results in increased expression of GPT protein]		 CTD PMID:25753322 PMID:25779342 PMID:29753871 PMID:30506662 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of GPT2 mRNA CTD PMID:24356939 NCBI chr19:22,599,003...22,633,529
Ensembl chr19:22,590,881...22,632,071 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased expression of GPX1 mRNA
Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of GPX1 mRNA]		 CTD PMID:23542512 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO Cyclophosphamide results in increased expression of GPX3 mRNA CTD PMID:21041162 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression ISO Cyclophosphamide results in increased expression of GPX4 protein CTD PMID:17475930 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity		 ISO
EXP		 [[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione Disulfide; [Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein; Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of GSR protein]]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]
Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]		 CTD PMID:12114195 PMID:21772021 PMID:23542512 PMID:25446862 PMID:25753322 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO GSTA1 protein affects the metabolism of [Cyclophosphamide metabolite co-treated with Glutathione] CTD PMID:12516103 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO [GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide]; GSTM1 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin] CTD PMID:16087946 PMID:28744217 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Cyclophosphamide results in decreased expression of GSTM2 mRNA CTD PMID:11906922 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases response to substance
affects response to substance
increases expression		 ISO
EXP		 GSTP1 gene SNP results in increased susceptibility to [Carmustine co-treated with Doxorubicin co-treated with Cyclophosphamide co-treated with Melphalan]
GSTP1 protein results in decreased susceptibility to Cyclophosphamide
GSTP1 protein affects the susceptibility to Cyclophosphamide
GSTP1 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; Mesna inhibits the reaction [GSTP1 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]]
Cyclophosphamide results in increased expression of GSTP1 mRNA; Cyclophosphamide results in increased expression of GSTP1 protein		 CTD PMID:10954901 PMID:12791655 PMID:16141653 PMID:16242832 PMID:19696094 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Gtf2b general transcription factor IIB increases expression EXP Cyclophosphamide results in increased expression of GTF2B mRNA CTD PMID:27281708 NCBI chr 2:248,709,433...248,727,741
Ensembl chr 2:248,715,281...248,727,741 		JBrowse link
G Gtf3c1 general transcription factor IIIC subunit 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of GTF3C1 mRNA CTD PMID:16322899 NCBI chr 1:197,032,473...197,098,676
Ensembl chr 1:197,032,474...197,098,649 		JBrowse link
G Gusb glucuronidase, beta decreases expression
increases activity
multiple interactions		 EXP Cyclophosphamide results in decreased expression of GUSB protein
Cyclophosphamide results in increased activity of GUSB protein
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of GUSB protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in increased activity of GUSB protein]		 CTD PMID:17686619 PMID:25451569 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771 		JBrowse link
G Gzma granzyme A decreases expression ISO Cyclophosphamide results in decreased expression of GZMA mRNA CTD PMID:21041162 NCBI chr 2:44,968,846...44,981,436
Ensembl chr 2:44,968,765...44,981,458 		JBrowse link
G Gzmb granzyme B increases expression ISO Cyclophosphamide results in increased expression of GZMB mRNA CTD PMID:15331540 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Cyclophosphamide results in increased phosphorylation of H2AX protein CTD PMID:32482060 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hcrt hypocretin neuropeptide precursor affects localization
decreases expression		 EXP Cyclophosphamide affects the localization of HCRT protein
Cyclophosphamide results in decreased expression of HCRT mRNA		 CTD PMID:17881193 PMID:19666069 NCBI chr10:88,669,216...88,670,430
Ensembl chr10:88,669,214...88,670,430 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO Cyclophosphamide results in increased expression of HIF1A mRNA CTD PMID:15331540 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hinfp histone H4 transcription factor decreases expression EXP Cyclophosphamide results in decreased expression of HINFP mRNA CTD PMID:27281708 NCBI chr 8:48,626,398...48,638,012
Ensembl chr 8:48,628,340...48,634,797 		JBrowse link
G Hm13 histocompatibility minor 13 decreases expression ISO Cyclophosphamide results in decreased expression of H13 mRNA CTD PMID:15331540 NCBI chr 3:148,150,695...148,189,623
Ensembl chr 3:148,150,698...148,189,623 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Cyclophosphamide metabolite results in increased expression of HMGCS1 mRNA CTD PMID:24356939 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression
decreases expression
multiple interactions
increases expression		 EXP
ISO		 Cyclophosphamide affects the expression of HMOX1 mRNA
Cyclophosphamide results in decreased expression of HMOX1 protein
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of HMOX1 protein; Hemin inhibits the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]
Cyclophosphamide results in increased expression of HMOX1 mRNA; Cyclophosphamide results in increased expression of HMOX1 protein		 CTD PMID:11906922 PMID:17979934 PMID:18206168 PMID:18246545 PMID:19952508 PMID:20038455 PMID:20433640 PMID:32197949 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hmox2 heme oxygenase 2 decreases expression EXP Cyclophosphamide results in decreased expression of HMOX2 mRNA CTD PMID:11906922 NCBI chr10:10,990,034...11,035,493
Ensembl chr10:10,990,034...11,035,484 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K increases expression ISO
EXP		 Cyclophosphamide results in increased expression of HNRNPK protein
Cyclophosphamide results in increased expression of HNRNPK mRNA		 CTD PMID:11599041 PMID:17475930 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654 		JBrowse link
G Hoxa1 homeobox A1 affects response to substance ISO HOXA1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 4:82,124,358...82,127,182
Ensembl chr 4:82,125,406...82,127,066 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis ISO
EXP		 Cyclophosphamide results in increased mutagenesis of HPRT1 gene CTD PMID:17116724 PMID:23677247 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression EXP Cyclophosphamide results in decreased expression of HSP90AA1 mRNA CTD PMID:11906922 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression EXP Cyclophosphamide results in decreased expression of HSP90AB1 mRNA CTD PMID:11906922 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression
increases expression		 EXP Cyclophosphamide results in decreased expression of HSP90B1 mRNA
Cyclophosphamide results in increased expression of HSP90B1 mRNA		 CTD PMID:11599041 PMID:11906922 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A affects expression
increases expression		 EXP
ISO		 Cyclophosphamide affects the expression of HSPA1A mRNA
Cyclophosphamide results in increased expression of HSPA1A mRNA; Cyclophosphamide results in increased expression of HSPA1A protein		 CTD PMID:8917683 PMID:18246545 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B affects expression
increases expression
decreases expression		 EXP
ISO		 Cyclophosphamide affects the expression of HSPA1B mRNA
Cyclophosphamide metabolite results in increased expression of HSPA1B mRNA
Cyclophosphamide results in decreased expression of HSPA1B mRNA		 CTD PMID:16141653 PMID:18246545 PMID:24356939 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 affects response to substance
increases expression		 ISO
EXP		 HSPA2 protein affects the susceptibility to Cyclophosphamide
Cyclophosphamide results in increased expression of HSPA2 mRNA		 CTD PMID:11599041 PMID:16217747 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
increases expression		 EXP
ISO		 Cyclophosphamide results in decreased expression of HSPA5 mRNA
Cyclophosphamide metabolite results in increased expression of HSPA5 mRNA		 CTD PMID:11906922 PMID:24356939 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 affects response to substance ISO HSPA8 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 decreases expression EXP Cyclophosphamide results in decreased expression of HSPA9 mRNA CTD PMID:11906922 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression
increases expression		 EXP Cyclophosphamide results in decreased expression of HSPB1 mRNA
Cyclophosphamide results in increased expression of HSPB1 mRNA		 CTD PMID:11599041 PMID:11906922 PMID:18246545 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression EXP Cyclophosphamide results in decreased expression of HSPD1 mRNA CTD PMID:11906922 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 decreases expression EXP Cyclophosphamide results in decreased expression of HSPE1 mRNA CTD PMID:11906922 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO Cyclophosphamide metabolite results in increased expression of HSPH1 mRNA CTD PMID:24356939 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902 		JBrowse link
G Hyls1 HYLS1, centriolar and ciliogenesis associated decreases expression ISO Cyclophosphamide metabolite results in decreased expression of HYLS1 mRNA CTD PMID:24356939 NCBI chr 8:36,763,470...36,772,199
Ensembl chr 8:36,763,481...36,764,422 		JBrowse link
G Hyou1 hypoxia up-regulated 1 decreases expression EXP Cyclophosphamide results in decreased expression of HYOU1 mRNA CTD PMID:11906922 NCBI chr 8:48,699,796...48,711,912
Ensembl chr 8:48,699,769...48,711,910 		JBrowse link
G Ica1 islet cell autoantigen 1 affects response to substance ISO ICA1 protein affects the susceptibility to Cyclophosphamide CTD PMID:11751995 NCBI chr 4:34,635,509...34,780,187
Ensembl chr 4:34,635,506...34,780,193 		JBrowse link
G Icam1 intercellular adhesion molecule 1 affects response to substance ISO ICAM1 protein affects the susceptibility to Cyclophosphamide CTD PMID:11591119 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of ID2 mRNA CTD PMID:24356939 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO Cyclophosphamide metabolite results in increased expression of IDI1 mRNA CTD PMID:24356939 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036 		JBrowse link
G Ier3 immediate early response 3 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of IER3 mRNA CTD PMID:24356939 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769 		JBrowse link
G Ier5 immediate early response 5 increases expression ISO Cyclophosphamide results in increased expression of IER5 mRNA CTD PMID:21527772 NCBI chr13:72,742,210...72,744,302
Ensembl chr13:72,742,210...72,744,303 		JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression ISO Cyclophosphamide results in increased expression of IFIT2 mRNA CTD PMID:15331540 NCBI chr 1:252,894,663...252,900,727
Ensembl chr 1:252,894,663...252,900,726 		JBrowse link
G Ifng interferon gamma affects expression
multiple interactions
decreases secretion
increases expression
decreases expression		 ISO
EXP		 Cyclophosphamide affects the expression of IFNG mRNA
[Cyclophosphamide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA
Cyclophosphamide results in decreased secretion of IFNG protein
Cyclophosphamide results in increased expression of IFNG mRNA
Cyclophosphamide results in decreased expression of IFNG mRNA
Cyclophosphamide results in increased expression of IFNG protein
(4-formyl-9-methoxy-5-methyl-naphtho(2,3-b)furan-3-yl)methyl acetate inhibits the reaction [Cyclophosphamide results in decreased secretion of IFNG protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IFNG mRNA]; IFNG protein inhibits the reaction [Cyclophosphamide results in increased abundance of Nitric Oxide]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IFNG mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IFNG protein]		 CTD PMID:10607705 PMID:11006010 PMID:11014644 PMID:15331540 PMID:18848347 PMID:18957084 PMID:21068404 PMID:22842586 PMID:23395935 PMID:29594315 PMID:32151603 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Ifngr1 interferon gamma receptor 1 decreases expression ISO Cyclophosphamide results in decreased expression of IFNGR1 mRNA CTD PMID:21041162 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of IFRD1 mRNA CTD PMID:24356939 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420 		JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 affects response to substance ISO IGF2BP3 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 4:78,744,683...78,879,457
Ensembl chr 4:78,746,547...78,879,294 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects response to substance
decreases expression		 ISO
EXP		 IGFBP3 protein affects the susceptibility to Cyclophosphamide
Cyclophosphamide results in decreased expression of IGFBP3 mRNA		 CTD PMID:16141653 PMID:16217747 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374 		JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 multiple interactions ISO IGFBP4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr10:86,950,555...86,962,563
Ensembl chr10:86,950,557...86,962,578 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression ISO Cyclophosphamide results in decreased expression of IGFBP5 mRNA CTD PMID:15331540 PMID:20849824 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033 		JBrowse link
G Igkc immunoglobulin kappa constant decreases expression ISO Cyclophosphamide results in decreased expression of IGKC mRNA CTD PMID:15331540
G Il10 interleukin 10 decreases expression
multiple interactions
increases expression		 ISO
EXP		 Cyclophosphamide results in decreased expression of IL10 mRNA
[Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL10 protein
Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein]
Cyclophosphamide results in increased expression of IL10 mRNA
Cyclophosphamide results in increased expression of IL10 protein		 CTD PMID:11014644 PMID:11948286 PMID:18848347 PMID:21068404 PMID:25451569 PMID:31651976 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] results in decreased expression of [IL12A protein binds to IL12B protein] CTD PMID:29228376 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318 		JBrowse link
G Il12b interleukin 12B affects expression
multiple interactions
increases expression		 ISO Cyclophosphamide affects the expression of IL12B mRNA
[Doxorubicin co-treated with Cyclophosphamide] results in decreased expression of [IL12A protein binds to IL12B protein]
Cyclophosphamide results in increased expression of IL12B mRNA		 CTD PMID:15331540 PMID:18957084 PMID:22842586 PMID:29228376 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 increases expression ISO Cyclophosphamide results in increased expression of IL13RA1 mRNA CTD PMID:21041162 NCBI chr  X:122,724,081...122,783,801
Ensembl chr  X:122,724,129...122,781,479 		JBrowse link
G Il15 interleukin 15 multiple interactions
decreases secretion		 ISO (4-formyl-9-methoxy-5-methyl-naphtho(2,3-b)furan-3-yl)methyl acetate inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein] CTD PMID:23395935 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha increases expression ISO Cyclophosphamide results in increased expression of IL15RA mRNA CTD PMID:21041162 NCBI chr17:70,451,861...70,481,838
Ensembl chr17:70,451,411...70,481,750 		JBrowse link
G Il16 interleukin 16 decreases expression ISO Cyclophosphamide results in decreased expression of IL16 mRNA CTD PMID:21041162 NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912 		JBrowse link
G Il17a interleukin 17A decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased expression of IL17A protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL17A protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL17A protein]		 CTD PMID:21880982 PMID:32151603 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786 		JBrowse link
G Il18 interleukin 18 increases expression EXP Cyclophosphamide results in increased expression of IL18 protein CTD PMID:18848347 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il1a interleukin 1 alpha increases expression
multiple interactions
affects response to substance		 ISO
EXP		 Cyclophosphamide results in increased expression of IL1A mRNA
[Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL1A protein
Cyclophosphamide results in increased expression of IL1A protein
IL1A promoter polymorphism affects the susceptibility to Cyclophosphamide		 CTD PMID:15331540 PMID:16636934 PMID:18848347 PMID:31651976 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
increases response to substance
multiple interactions		 ISO
EXP		 Cyclophosphamide results in increased expression of IL1B mRNA; Cyclophosphamide results in increased expression of IL1B protein
Cyclophosphamide results in decreased expression of IL1B protein
IL1B protein results in increased susceptibility to Cyclophosphamide
[Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL1B protein; [Doxorubicin co-treated with Cyclophosphamide] results in decreased expression of IL1B protein; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL1B protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL1B protein]; VIP protein inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]; Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]		 CTD PMID:8634684 PMID:11948286 PMID:15331540 PMID:18206168 PMID:18483878 PMID:18710439 PMID:18848347 PMID:20126887 PMID:23695977 PMID:25451569 PMID:29228376 PMID:29753871 PMID:30506662 PMID:31651976 PMID:32151603 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO Cyclophosphamide results in increased expression of IL1RN mRNA CTD PMID:15331540 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614 		JBrowse link
G Il2 interleukin 2 increases expression
decreases expression
decreases secretion
multiple interactions		 ISO
EXP		 Cyclophosphamide results in increased expression of IL2 mRNA
Cyclophosphamide results in decreased expression of IL2 mRNA
Cyclophosphamide results in decreased secretion of IL2 protein
(4-formyl-9-methoxy-5-methyl-naphtho(2,3-b)furan-3-yl)methyl acetate inhibits the reaction [Cyclophosphamide results in decreased secretion of IL2 protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL2 mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL2 mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL2 protein]
Cyclophosphamide results in decreased expression of IL2 protein		 CTD PMID:11006010 PMID:11948286 PMID:18848347 PMID:23395935 PMID:32151603 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il21 interleukin 21 multiple interactions
decreases expression		 ISO Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL21 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL21 protein] CTD PMID:32151603 NCBI chr 2:123,965,021...123,972,356
Ensembl chr 2:123,965,021...123,972,356 		JBrowse link
G Il23a interleukin 23 subunit alpha decreases secretion
decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased secretion of IL23A protein
Cyclophosphamide results in decreased expression of IL23A protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL23A protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL23A protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL23A protein]		 CTD PMID:23395935 PMID:32151603 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723 		JBrowse link
G Il3 interleukin 3 multiple interactions ISO [Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL3 protein CTD PMID:31651976 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973 		JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions
increases expression		 ISO
EXP		 Cyclophosphamide results in decreased expression of IL4 mRNA; Cyclophosphamide results in decreased expression of IL4 protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL4 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL4 protein]
Cyclophosphamide results in increased expression of IL4 mRNA; Cyclophosphamide results in increased expression of IL4 protein		 CTD PMID:11006010 PMID:11014644 PMID:11948286 PMID:18848347 PMID:22842586 PMID:32151603 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il5 interleukin 5 increases expression ISO
EXP		 Cyclophosphamide results in increased expression of IL5 mRNA; Cyclophosphamide results in increased expression of IL5 protein CTD PMID:11006010 PMID:18848347 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
decreases secretion		 ISO
EXP		 [Doxorubicin co-treated with Cyclophosphamide] results in decreased expression of IL6 protein; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL6 protein]; Sizofiran promotes the reaction [Cyclophosphamide results in increased expression of IL6 mRNA]; Sizofiran promotes the reaction [Cyclophosphamide results in increased expression of IL6 protein]
Cyclophosphamide results in increased expression of IL6 mRNA; Cyclophosphamide results in increased expression of IL6 protein
Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]		 CTD PMID:10052129 PMID:11948286 PMID:17010015 PMID:18848347 PMID:20126887 PMID:21068404 PMID:22842586 PMID:23395935 PMID:23695977 PMID:25753322 PMID:29228376 PMID:30506662 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Ilf3 interleukin enhancer binding factor 3 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of ILF3 mRNA CTD PMID:16322899 NCBI chr 8:22,402,877...22,440,984
Ensembl chr 8:22,402,890...22,440,885 		JBrowse link
G Irag2 inositol 1,4,5-triphosphate receptor associated 2 decreases expression ISO Cyclophosphamide results in decreased expression of LRMP mRNA CTD PMID:21041162 NCBI chr 4:179,402,929...179,440,792
Ensembl chr 4:179,398,621...179,440,792 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of IRS1 mRNA CTD PMID:16322899 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression ISO Cyclophosphamide results in increased expression of ISG15 mRNA CTD PMID:21527772 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248 		JBrowse link
G Isl2 ISL LIM homeobox 2 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of ISL2 mRNA CTD PMID:24356939 NCBI chr 8:60,117,565...60,122,716
Ensembl chr 8:60,117,729...60,122,211 		JBrowse link
G Itk IL2-inducible T-cell kinase decreases expression ISO Cyclophosphamide results in decreased expression of ITK mRNA CTD PMID:21041162 NCBI chr10:31,431,820...31,493,413
Ensembl chr10:31,431,809...31,493,419 		JBrowse link
G Jchain joining chain of multimeric IgA and IgM decreases expression ISO Cyclophosphamide results in decreased expression of JCHAIN mRNA CTD PMID:15331540 NCBI chr14:21,176,841...21,183,731
Ensembl chr14:21,177,237...21,183,542 		JBrowse link
G Kbtbd11 kelch repeat and BTB domain containing 11 decreases expression ISO Cyclophosphamide results in decreased expression of KBTBD11 mRNA CTD PMID:17403535 NCBI chr16:79,696,395...79,716,129
Ensembl chr16:79,696,891...79,700,992 		JBrowse link
G Kcnq4 potassium voltage-gated channel subfamily Q member 4 decreases expression ISO Cyclophosphamide results in decreased expression of KCNQ4 mRNA CTD PMID:20849824 NCBI chr 5:139,625,783...139,677,300
Ensembl chr 5:139,627,576...139,677,300 		JBrowse link
G Kdm1a lysine demethylase 1A multiple interactions
increases expression		 ISO Cyclophosphamide promotes the reaction [KDM1A protein results in decreased methylation of and results in decreased degradation of DNMT1 protein]
Cyclophosphamide results in increased expression of KDM1A protein		 CTD PMID:22007908 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171 		JBrowse link
G Kdm2a lysine demethylase 2A increases expression EXP Cyclophosphamide results in increased expression of KDM2A mRNA CTD PMID:27281708 NCBI chr 1:219,566,130...219,642,294
Ensembl chr 1:219,566,156...219,640,294 		JBrowse link
G Kdm4b lysine demethylase 4B multiple interactions ISO KDM4B mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 9:10,656,035...10,734,127
Ensembl chr 9:10,653,216...10,734,073 		JBrowse link
G Kdr kinase insert domain receptor decreases expression
increases expression		 EXP Cyclophosphamide results in decreased expression of KDR mRNA; Cyclophosphamide results in decreased expression of KDR protein
Cyclophosphamide results in increased expression of KDR mRNA		 CTD PMID:18632792 PMID:19701751 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Kif21b kinesin family member 21B decreases expression ISO Cyclophosphamide metabolite results in decreased expression of KIF21B mRNA CTD PMID:24356939 NCBI chr13:52,976,505...53,026,750
Ensembl chr13:52,976,507...53,023,103 		JBrowse link
G Kif3a kinesin family member 3a multiple interactions ISO KIF3A mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr10:38,918,705...38,953,958
Ensembl chr10:38,918,748...38,952,785 		JBrowse link
G Kitlg KIT ligand affects expression
increases expression
multiple interactions		 ISO Cyclophosphamide affects the expression of KITL mRNA
Cyclophosphamide results in increased expression of KITL mRNA
[Cyclophosphamide co-treated with Sizofiran] results in increased expression of KITL mRNA		 CTD PMID:10052129 PMID:12624490 PMID:12662436 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054 		JBrowse link
G Klf13 Kruppel-like factor 13 decreases expression ISO Cyclophosphamide results in decreased expression of KLF13 mRNA CTD PMID:21041162 NCBI chr 1:124,772,596...124,803,363
Ensembl chr 1:124,772,596...124,803,363 		JBrowse link
G Klf2 Kruppel-like factor 2 increases expression ISO Cyclophosphamide results in increased expression of KLF2 mRNA CTD PMID:21041162 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037 		JBrowse link
G Klf4 Kruppel like factor 4 decreases response to substance ISO KLF4 results in decreased susceptibility to Cyclophosphamide CTD PMID:21833590 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669 		JBrowse link
G Klf5 Kruppel-like factor 5 affects response to substance ISO KLF5 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921 		JBrowse link
G Krcc1 lysine-rich coiled-coil 1 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of KRCC1 mRNA CTD PMID:24356939 NCBI chr 4:99,133,735...99,148,236
Ensembl chr 4:99,133,842...99,146,827 		JBrowse link
G Krt8 keratin 8 decreases expression ISO Cyclophosphamide results in decreased expression of KRT8 mRNA CTD PMID:21621594 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803 		JBrowse link
G Krt80 keratin 80 increases expression ISO Cyclophosphamide results in increased expression of KRT80 mRNA CTD PMID:21527772 NCBI chr 7:142,995,715...143,015,932
Ensembl chr 7:142,994,119...143,016,040 		JBrowse link
G Lama5 laminin subunit alpha 5 increases expression
multiple interactions		 ISO Cyclophosphamide results in increased expression of LAMA5 mRNA
5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline inhibits the reaction [Cyclophosphamide results in increased expression of LAMA5 mRNA]		 CTD PMID:30760223 NCBI chr 3:175,553,042...175,601,112
Ensembl chr 3:175,553,045...175,601,127 		JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO Cyclophosphamide results in increased expression of LAMC2 mRNA CTD PMID:21527772 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252 		JBrowse link
G Lasp1 LIM and SH3 protein 1 decreases expression EXP Cyclophosphamide results in decreased expression of LASP1 mRNA CTD PMID:27281708 NCBI chr10:85,744,662...85,785,130
Ensembl chr10:85,744,568...85,785,133 		JBrowse link
G Lat linker for activation of T cells decreases expression ISO Cyclophosphamide results in decreased expression of LAT mRNA CTD PMID:21041162 NCBI chr 1:197,765,644...197,770,669
Ensembl chr 1:197,765,644...197,770,669 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases expression ISO Cyclophosphamide results in decreased expression of LCK mRNA CTD PMID:21041162 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983 		JBrowse link
G Lcn2 lipocalin 2 increases expression
multiple interactions		 ISO
EXP		 Cyclophosphamide results in increased expression of LCN2 mRNA
[Cyclophosphamide co-treated with Mecamylamine] results in increased expression of LCN2 mRNA		 CTD PMID:15331540 PMID:18433785 PMID:20623750 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546 		JBrowse link
G Ldhb lactate dehydrogenase B affects response to substance ISO LDHB protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Cyclophosphamide results in decreased expression of LEF1 mRNA CTD PMID:21041162 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056 		JBrowse link
G Lgals1 galectin 1 increases expression ISO Cyclophosphamide results in increased expression of LGALS1 mRNA CTD PMID:17403535 NCBI chr 7:120,153,184...120,156,290
Ensembl chr 7:120,153,184...120,156,289 		JBrowse link
G Lgals7 galectin 7 increases expression ISO Cyclophosphamide results in increased expression of LGALS7 mRNA CTD PMID:21527772 NCBI chr 1:87,044,823...87,047,223
Ensembl chr 1:87,045,335...87,047,223 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases secretion
multiple interactions		 EXP Cyclophosphamide results in decreased secretion of LHB protein
sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of LHB protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of LHB protein]		 CTD PMID:25446862 PMID:32197949 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724 		JBrowse link
G Lhx2 LIM homeobox 2 decreases expression EXP Cyclophosphamide results in decreased expression of LHX2 mRNA CTD PMID:27281708 NCBI chr 3:22,628,674...22,658,447
Ensembl chr 3:22,640,545...22,658,446 		JBrowse link
G Limd1 LIM domains containing 1 increases expression EXP Cyclophosphamide results in increased expression of LIMD1 mRNA CTD PMID:27281708 NCBI chr 8:132,553,218...132,598,826
Ensembl chr 8:132,553,218...132,598,812 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Cyclophosphamide results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:144,192,989...144,252,554
Ensembl chr 4:144,192,989...144,252,551 		JBrowse link
G Lmnb1 lamin B1 multiple interactions ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of LMNB1 protein CTD PMID:15582267 NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264 		JBrowse link
G Lonrf2 LON peptidase N-terminal domain and ring finger 2 increases expression EXP Cyclophosphamide results in increased expression of LONRF2 mRNA CTD PMID:27281708 NCBI chr 9:45,468,001...45,506,448
Ensembl chr 9:45,466,688...45,505,767 		JBrowse link
G Lsg1 large 60S subunit nuclear export GTPase 1 decreases expression ISO Cyclophosphamide results in decreased expression of LSG1 mRNA CTD PMID:20849824 NCBI chr11:73,693,862...73,723,457
Ensembl chr11:73,693,814...73,723,501 		JBrowse link
G Ltbr lymphotoxin beta receptor increases expression ISO Cyclophosphamide results in increased expression of LTBR mRNA CTD PMID:21041162 NCBI chr 4:157,822,838...157,829,291
Ensembl chr 4:157,822,840...157,829,241 		JBrowse link
G Ltf lactotransferrin decreases expression ISO Cyclophosphamide results in decreased expression of LTF mRNA CTD PMID:21621594 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261 		JBrowse link
G Maged1 MAGE family member D1 affects response to substance ISO MAGED1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr  X:63,803,194...63,809,715
Ensembl chr  X:63,803,189...63,809,861 		JBrowse link
G Man2b2 mannosidase, alpha, class 2B, member 2 decreases expression EXP Cyclophosphamide results in decreased expression of MAN2B2 mRNA CTD PMID:27281708 NCBI chr14:78,939,959...78,964,961
Ensembl chr14:78,939,903...78,964,961 		JBrowse link
G Maoa monoamine oxidase A increases expression ISO Cyclophosphamide results in increased expression of MAOA mRNA CTD PMID:17403535 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 affects expression EXP Cyclophosphamide affects the expression of MAP3K12 mRNA CTD PMID:18246545 NCBI chr 7:144,102,275...144,120,306
Ensembl chr 7:144,102,680...144,109,116 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
increases expression		 ISO
EXP		 Cyclophosphamide results in increased phosphorylation of MAPK1 protein
Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Cyclophosphamide results in increased expression of MAPK1 mRNA; Cyclophosphamide results in increased expression of MAPK1 protein modified form		 CTD PMID:11599041 PMID:15733095 PMID:17110531 PMID:17409261 PMID:19638304 PMID:19696094 PMID:19996110 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
decreases expression
affects expression		 ISO
EXP		 [Doxorubicin co-treated with Cyclophosphamide] affects the expression of MAPK14 mRNA
Cyclophosphamide results in decreased expression of MAPK14 mRNA
Cyclophosphamide affects the expression of MAPK14 mRNA		 CTD PMID:16322899 PMID:18246545 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
multiple interactions
increases phosphorylation		 EXP
ISO		 Cyclophosphamide results in increased expression of MAPK3 protein modified form
Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Cyclophosphamide results in increased phosphorylation of MAPK3 protein		 CTD PMID:15733095 PMID:17110531 PMID:17409261 PMID:19638304 PMID:19696094 PMID:19996110 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions EXP Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK7 protein CTD PMID:17110531 NCBI chr10:47,768,592...47,775,130
Ensembl chr10:47,766,680...47,775,055 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO
EXP		 Cyclophosphamide results in increased phosphorylation of MAPK8 protein
Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK8 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK8 protein]
GSTP1 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; GSTP2 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; Mesna inhibits the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; Mesna inhibits the reaction [GSTP1 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]]; Mesna inhibits the reaction [GSTP2 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]]		 CTD PMID:19696094 PMID:19996110 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK9 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK9 protein] CTD PMID:19996110 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO MAPT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517 		JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 decreases expression EXP Cyclophosphamide results in decreased expression of MARCHF7 mRNA CTD PMID:27281708 NCBI chr 3:46,284,961...46,325,230
Ensembl chr 3:46,286,712...46,324,057 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases expression ISO Cyclophosphamide results in increased expression of MARCKS mRNA CTD PMID:17403535 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 decreases expression ISO Cyclophosphamide results in decreased expression of MCM5 mRNA CTD PMID:21041162 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278 		JBrowse link
G Mdfic MyoD family inhibitor domain containing decreases expression ISO Cyclophosphamide results in decreased expression of MDFIC mRNA CTD PMID:17403535 NCBI chr 4:42,202,546...42,282,499
Ensembl chr 4:42,202,838...42,282,496 		JBrowse link
G Med13l mediator complex subunit 13L multiple interactions ISO MED13L mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr12:43,421,317...43,576,859
Ensembl chr12:43,421,308...43,576,804 		JBrowse link
G Melk maternal embryonic leucine zipper kinase multiple interactions ISO MELK mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 5:59,783,835...59,844,356
Ensembl chr 5:59,783,890...59,844,356 		JBrowse link
G Metrn meteorin, glial cell differentiation regulator multiple interactions ISO METRN mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr10:15,164,439...15,166,457
Ensembl chr10:15,164,439...15,166,457 		JBrowse link
G Mfge8 milk fat globule EGF and factor V/VIII domain containing decreases expression ISO Cyclophosphamide results in decreased expression of MFGE8 mRNA CTD PMID:15331540 NCBI chr 1:140,845,478...140,860,882
Ensembl chr 1:140,845,465...140,860,894 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression
decreases response to substance		 ISO Cyclophosphamide results in decreased expression of MGMT mRNA
MGMT protein results in decreased susceptibility to Cyclophosphamide		 CTD PMID:15741301 PMID:17403535 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases expression EXP Cyclophosphamide results in decreased expression of MGST1 mRNA CTD PMID:11906922 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607 		JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions EXP Cyclophosphamide affects the localization of and affects the expression of MIF protein; Cyclophosphamide promotes the reaction [MIF protein binds to CXCR4 protein] CTD PMID:19066630 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859 		JBrowse link
G Mlh1 mutL homolog 1 decreases expression EXP Cyclophosphamide results in decreased expression of MLH1 mRNA CTD PMID:11906922 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964 		JBrowse link
G Mmel1 membrane metallo-endopeptidase-like 1 increases expression EXP Cyclophosphamide results in increased expression of MMEL1 mRNA CTD PMID:27281708 NCBI chr 5:172,273,450...172,303,905
Ensembl chr 5:172,273,459...172,304,225 		JBrowse link
G Mmp11 matrix metallopeptidase 11 decreases expression EXP Cyclophosphamide results in decreased expression of MMP11 mRNA CTD PMID:27281708 NCBI chr20:13,670,051...13,678,834
Ensembl chr20:13,670,066...13,678,089 		JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO Cyclophosphamide results in increased expression of MMP3 mRNA CTD PMID:15331540 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579 		JBrowse link
G Mmp8 matrix metallopeptidase 8 increases expression EXP Cyclophosphamide results in increased expression of MMP8 mRNA CTD PMID:27281708 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702 		JBrowse link
G Mnda myeloid cell nuclear differentiation antigen increases expression ISO Cyclophosphamide results in increased expression of IFI204 mRNA CTD PMID:21041162 NCBI chr13:92,073,664...92,091,335
Ensembl chr13:92,073,668...92,089,980 		JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 affects response to substance ISO MPC2 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr13:83,680,527...83,700,491
Ensembl chr13:83,681,322...83,700,213 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase affects expression EXP Cyclophosphamide affects the expression of MPG mRNA CTD PMID:11906922 NCBI chr10:15,661,768...15,667,995
Ensembl chr10:15,661,608...15,668,022 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity		 EXP Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein]; Hemin inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein]; Rolipram inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein] CTD PMID:10749792 PMID:17979934 PMID:18710439 PMID:25451569 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Mr1 major histocompatibility complex, class I-related increases expression ISO Cyclophosphamide results in increased expression of MR1 mRNA CTD PMID:21527772 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841 		JBrowse link
G Ms4a3 membrane spanning 4-domains A3 decreases expression ISO Cyclophosphamide results in decreased expression of MS4A3 mRNA CTD PMID:17403535 NCBI chr 1:227,979,307...227,994,210
Ensembl chr 1:227,979,481...227,992,623 		JBrowse link
G Msh2 mutS homolog 2 decreases expression EXP Cyclophosphamide results in decreased expression of MSH2 mRNA CTD PMID:11056294 PMID:11906922 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932 		JBrowse link
G Msh3 mutS homolog 3 decreases expression EXP Cyclophosphamide results in decreased expression of MSH3 mRNA CTD PMID:11906922 NCBI chr 2:21,790,048...21,931,791
Ensembl chr 2:21,790,044...21,931,720 		JBrowse link
G Mss51 MSS51 mitochondrial translational activator increases expression EXP Cyclophosphamide results in increased expression of MSS51 mRNA CTD PMID:27281708 NCBI chr15:4,240,203...4,252,072
Ensembl chr15:4,240,203...4,252,072 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases expression ISO Cyclophosphamide metabolite results in decreased expression of MTHFD2 mRNA CTD PMID:24356939 NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase decreases expression EXP Cyclophosphamide results in decreased expression of MTR mRNA CTD PMID:27281708 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014 		JBrowse link
G Muc13 mucin 13, cell surface associated increases expression ISO Cyclophosphamide results in increased expression of MUC13 mRNA CTD PMID:15331540 NCBI chr11:70,185,757...70,223,012
Ensembl chr11:70,185,757...70,211,701 		JBrowse link
G Mxi1 MAX interactor 1, dimerization protein affects response to substance ISO MXI1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr 1:274,030,748...274,090,071
Ensembl chr 1:274,030,978...274,090,071 		JBrowse link
G Myh10 myosin heavy chain 10 affects response to substance ISO MYH10 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr10:55,274,910...55,406,738
Ensembl chr10:55,275,411...55,406,732 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 multiple interactions ISO [Doxorubicin co-treated with Cyclophosphamide] affects the expression of NAIP mRNA CTD PMID:16322899 NCBI chr 2:30,377,505...30,418,578 JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression ISO Cyclophosphamide results in increased expression of NAMPT mRNA CTD PMID:21041162 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472 		JBrowse link
G Nanos1 nanos C2HC-type zinc finger 1 increases expression ISO Cyclophosphamide metabolite results in increased expression of NANOS1 mRNA CTD PMID:24356939 NCBI chr 1:282,134,676...282,140,370
Ensembl chr 1:282,134,981...282,135,772 		JBrowse link
G Nasp nuclear autoantigenic sperm protein increases expression EXP Cyclophosphamide results in increased expression of NASP mRNA CTD PMID:16141653 NCBI chr 5:135,446,485...135,472,113
Ensembl chr 5:135,446,962...135,472,116 		JBrowse link
G Ncoa7 nuclear receptor coactivator 7 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of NCOA7 mRNA CTD PMID:24356939 NCBI chr 1:29,225,727...29,386,642
Ensembl chr 1:29,225,707...29,385,199 		JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 decreases expression ISO Cyclophosphamide results in decreased expression of NDUFS2 mRNA CTD PMID:15331540 NCBI chr13:89,606,848...89,623,506
Ensembl chr13:89,606,840...89,619,398 		JBrowse link
G Neto2 neuropilin and tolloid like 2 increases expression ISO Cyclophosphamide results in increased expression of NETO2 mRNA CTD PMID:21527772 NCBI chr19:22,450,579...22,486,530
Ensembl chr19:22,450,030...22,486,531 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 decreases expression ISO Cyclophosphamide results in decreased expression of NFATC3 mRNA CTD PMID:21041162 NCBI chr19:38,039,542...38,114,003
Ensembl chr19:38,039,564...38,114,003 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases response to substance
increases expression
decreases expression		 EXP
ISO		 [astaxanthine co-treated with Cyclophosphamide] results in increased expression of NFE2L2 protein; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 protein]
Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of CAT protein]; Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of GCLC protein]; Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Cyclophosphamide results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of CAT protein]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]
NFE2L2 gene mutant form results in increased susceptibility to Cyclophosphamide
Cyclophosphamide results in increased expression of NFE2L2 protein		 CTD PMID:20038455 PMID:20433640 PMID:27633142 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfe2l3 nuclear factor, erythroid 2-like 3 decreases expression ISO Cyclophosphamide metabolite results in decreased expression of NFE2L3 mRNA CTD PMID:24356939 NCBI chr 4:81,205,214...81,233,068
Ensembl chr 4:81,205,404...81,232,813 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions		 ISO Cyclophosphamide results in increased phosphorylation of NFKBIA protein
ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased phosphorylation of NFKBIA protein]		 CTD PMID:30506662 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression ISO Cyclophosphamide results in increased expression of NFKBIZ mRNA CTD PMID:15331540 NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487 		JBrowse link
G Ngf nerve growth factor multiple interactions
increases expression
decreases expression		 ISO
EXP		 3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester inhibits the reaction [Cyclophosphamide results in increased expression of NGF protein]; Cyclophosphamide promotes the reaction [NGF results in increased expression of VEGFA mRNA]; VIP protein affects the reaction [Cyclophosphamide results in increased expression of NGF protein]
Cyclophosphamide results in decreased expression of NGF protein
Cyclophosphamide results in increased expression of NGF mRNA; Cyclophosphamide results in increased expression of NGF protein
NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of AKT1 protein]; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK8 protein]; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK9 protein]; rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NGF protein]		 CTD PMID:10683293 PMID:16879691 PMID:18299998 PMID:18632792 PMID:19996110 PMID:20127836 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Ngfr nerve growth factor receptor increases expression EXP Cyclophosphamide results in increased expression of NGFR mRNA; Cyclophosphamide results in increased expression of NGFR protein CTD PMID:8817519 PMID:18189308 PMID:18842820 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061 		JBrowse link
G Nid1 nidogen 1 affects response to substance ISO NID1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr17:90,553,161...90,627,133
Ensembl chr17:90,553,394...90,627,101 		JBrowse link
G Nkain1 Sodium/potassium transporting ATPase interacting 1 multiple interactions ISO NKAIN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 5:148,635,537...148,669,709
Ensembl chr 5:148,661,070...148,667,746 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 increases expression EXP Cyclophosphamide results in increased expression of NME1 mRNA CTD PMID:11599041 NCBI chr10:81,657,152...81,666,542
Ensembl chr10:81,657,153...81,666,523 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
increases activity		 EXP
ISO		 Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 mRNA]; Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; ginkgolide B inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 mRNA]; Rolipram inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]
Cyclophosphamide results in increased expression of NOS2 mRNA; Cyclophosphamide results in increased expression of NOS2 protein		 CTD PMID:9006340 PMID:10607705 PMID:11046124 PMID:15821589 PMID:16879691 PMID:18206168 PMID:18296739 PMID:18710439 PMID:19691848 PMID:21068404 PMID:25753322 PMID:29753871 PMID:32197949 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases activity
increases expression		 EXP Cyclophosphamide results in decreased activity of NOS3 protein
Cyclophosphamide results in increased expression of NOS3 protein		 CTD PMID:9006340 PMID:16125470 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nppb natriuretic peptide B increases expression ISO Cyclophosphamide results in increased expression of NPPB protein CTD PMID:17562616 PMID:18548196 PMID:18999883 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Nprl2 NPR2-like, GATOR1 complex subunit decreases expression ISO Cyclophosphamide results in decreased expression of NPRL2 mRNA CTD PMID:20849824 NCBI chr 8:116,297,950...116,301,123
Ensembl chr 8:116,297,950...116,301,122 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions
increases expression		 EXP
ISO		 Cyclophosphamide results in decreased expression of NQO1 mRNA; Cyclophosphamide results in decreased expression of NQO1 protein
Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Cyclophosphamide results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]
Cyclophosphamide results in increased expression of NQO1 protein
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NQO1 protein; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]; sacubitril-valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]		 CTD PMID:11906922 PMID:20038455 PMID:20433640 PMID:21041162 PMID:27633142 PMID:32197949 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression EXP Cyclophosphamide results in decreased expression of NR1H4 mRNA CTD PMID:28391356 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO Cyclophosphamide results in increased activity of NR1I2 protein
[Cyclophosphamide results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; [Cyclophosphamide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Cyclophosphamide binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [Cyclophosphamide results in increased expression of ABCB1 protein]		 CTD PMID:17041008 PMID:18839173 PMID:20041327 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Cyclophosphamide results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA CTD PMID:17041008 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Nr2c2 nuclear receptor subfamily 2, group C, member 2 increases expression EXP Cyclophosphamide results in increased expression of NR2C2 mRNA CTD PMID:27281708 NCBI chr 4:124,005,287...124,030,349
Ensembl chr 4:124,005,280...124,030,349 		JBrowse link
G Nrap nebulin-related anchoring protein increases expression EXP Cyclophosphamide results in increased expression of NRAP mRNA CTD PMID:27281708 NCBI chr 1:277,104,519...277,181,397
Ensembl chr 1:277,104,514...277,181,414 		JBrowse link
G Nrdc nardilysin convertase decreases expression EXP Cyclophosphamide results in decreased expression of NRD1 mRNA CTD PMID:27281708 NCBI chr 5:128,629,949...128,694,209
Ensembl chr 5:128,629,942...128,694,060 		JBrowse link
G Nrg1 neuregulin 1 increases expression ISO Cyclophosphamide results in increased expression of NRG1 mRNA CTD PMID:21527772 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434 		JBrowse link
G Nrp1 neuropilin 1 decreases expression
increases expression		 ISO
EXP		 Cyclophosphamide results in decreased expression of NRP1 mRNA
Cyclophosphamide results in increased expression of NRP1 mRNA		 CTD PMID:15331540 PMID:18632792 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858 		JBrowse link
G Nrp2 neuropilin 2 increases expression EXP Cyclophosphamide results in increased expression of NRP2 mRNA CTD PMID:18632792 NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087 		JBrowse link
G Nt5c2 5'-nucleotidase, cytosolic II increases expression ISO Cyclophosphamide results in increased expression of NT5C2 mRNA CTD PMID:20849824 NCBI chr 1:266,652,966...266,782,935
Ensembl chr 1:266,659,519...266,782,910 		JBrowse link
G Ntf3 neurotrophin 3 increases expression EXP Cyclophosphamide results in increased expression of NTF3 mRNA CTD PMID:10683293 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886 		JBrowse link
G Ntf4 neurotrophin 4 increases expression EXP Cyclophosphamide results in increased expression of NTF4 mRNA CTD PMID:10683293 NCBI chr 1:101,405,314...101,408,145
Ensembl chr 1:101,405,314...101,408,145 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions EXP Cyclophosphamide results in increased phosphorylation of and results in increased expression of NTRK1 protein CTD PMID:12412144 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions EXP Cyclophosphamide results in increased phosphorylation of and results in increased expression of NTRK2 protein CTD PMID:12412144 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676 		JBrowse link
G Nupl2 nucleoporin like 2 increases expression EXP Cyclophosphamide results in increased expression of NUPL2 mRNA CTD PMID:27281708 NCBI chr 4:7,512,326...7,529,106
Ensembl chr 4:7,512,326...7,529,106 		JBrowse link
G Ocln occludin decreases expression
multiple interactions		 ISO Cyclophosphamide results in decreased expression of OCLN protein
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of OCLN protein]		 CTD PMID:32151603 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Cyclophosphamide results in increased expression of ODC1 mRNA CTD PMID:11599041 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression ISO Cyclophosphamide results in decreased expression of OGG1 protein CTD PMID:27032448 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326 		JBrowse link
G Opn3 opsin 3 affects response to substance ISO OPN3 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 NCBI chr13:93,716,481...93,746,994
Ensembl chr13:93,716,481...93,746,994 		JBrowse link
G Osm oncostatin M affects expression ISO Cyclophosphamide affects the expression of OSM mRNA CTD PMID:12624490 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409 		JBrowse link
G P2rx3 purinergic receptor P2X 3 increases expression
multiple interactions		 EXP Cyclophosphamide results in increased expression of P2RX3 protein
GR 82334 inhibits the reaction [Cyclophosphamide results in increased expression of P2RX3 protein]; Suramin inhibits the reaction [Cyclophosphamide results in increased expression of P2RX3 protein]		 CTD PMID:23666265 NCBI chr 3:72,403,992...72,447,801
Ensembl chr 3:72,403,993...72,447,801 		JBrowse link
G P2ry2 purinergic receptor P2Y2 decreases expression ISO Cyclophosphamide results in decreased expression of P2RY2 mRNA CTD PMID:17403535 NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424 		JBrowse link
G Paip1 poly(A) binding protein interacting protein 1 decreases expression ISO Cyclophosphamide results in decreased expression of PAIP1 mRNA CTD PMID:20849824 NCBI chr 2:52,300,921...52,328,212
Ensembl chr 2:52,301,798...52,328,205 		JBrowse link
G Pard3 par-3 family cell polarity regulator decreases expression ISO Cyclophosphamide results in decreased expression of PARD3 mRNA CTD PMID:20849824 NCBI chr19:60,017,746...60,580,628
Ensembl chr19:60,017,746...60,580,651 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression
increases cleavage
decreases expression		 ISO
EXP		 [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of PARP1 protein
Cyclophosphamide results in increased expression of PARP1 mRNA
Cyclophosphamide results in increased cleavage of PARP1 protein
Cy