clonidine (imino form) - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	clonidine (imino form)	go back to main search page
Accession:	CHEBI:3757	browse the term
Definition:	A clonidine that has formula C9H9Cl2N3.
Synonyms:	exact_synonym:	2,6-dichloro-N-imidazolidin-2-ylideneaniline
	related_synonym:	2,6-dichloro-N-2-imidazolidinylidenebenzenamine; 2-[(2,6-dichlorophenyl)imino]imidazoline; Formula=C9H9Cl2N3; InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14); InChIKey=GJSURZIOUXUGAL-UHFFFAOYSA-N; SMILES=Clc1cccc(Cl)c1N=C1NCCN1
	xref:	Beilstein:746076; Beilstein:746077; CAS:4205-90-7; HMDB:HMDB0014714; KEGG:D00281
	xref_mesh:	MESH:D003000
	xref:	Reaxys:746076; Wikipedia:Clonidine
	cyclic_relationship:	is_tautomer_of CHEBI:46632

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Genes (52)

clonidine (imino form)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine A1 receptor

multiple interactions

[1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine

NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169

G

adrenergic receptor, alpha 2a

multiple interactions

Clonidine binds to and results in increased activity of ADRA2A protein
[5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine results in decreased activity of ADRA2A protein] which results in decreased susceptibility to Clonidine

PMID:10217548 PMID:12560108 PMID:12598592 PMID:16595736 PMID:17934014

NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413

G

adrenergic receptor, alpha 2b

multiple interactions

Clonidine binds to and results in increased activity of ADRA2B protein

NCBI chr 2:127,205,099...127,209,141
Ensembl chr 2:127,205,128...127,209,141

G

adrenergic receptor, alpha 2c

multiple interactions
increases response to substance

Clonidine binds to and results in increased activity of ADRA2C protein
ADRA2C results in increased susceptibility to Clonidine

PMID:8987795 PMID:10217548

NCBI chr 5:35,435,910...35,439,107
Ensembl chr 5:35,435,663...35,439,107

G

apoptosis-inducing factor, mitochondrion-associated 1

increases expression

Clonidine results in increased expression of AIFM1 protein

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

apolipoprotein A-I

decreases expression

Clonidine results in decreased expression of APOA1 protein

NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764

G

apolipoprotein A-II

decreases expression

Clonidine results in decreased expression of APOA2 protein

NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948

G

arginine vasopressin

increases expression

Clonidine results in increased expression of AVP protein

NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474

G

BCL2-associated agonist of cell death

increases expression

Clonidine results in increased expression of BAD protein

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

B cell leukemia/lymphoma 2

decreases expression

Clonidine results in decreased expression of BCL2 protein

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

increases expression

Clonidine results in increased expression of BCL2L1 mRNA

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

caspase 2

increases activity

Clonidine results in increased activity of CASP2 protein

NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442

G

caspase 3

increases expression
increases activity

Clonidine results in increased expression of CASP3 mRNA
Clonidine results in increased activity of CASP3 protein

PMID:15351510 PMID:28115640

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

increases activity

Clonidine results in increased activity of CASP8 protein

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

increases activity

Clonidine results in increased activity of CASP9 protein

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

C-C motif chemokine ligand 2

multiple interactions

Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

cystic fibrosis transmembrane conductance regulator

multiple interactions

Clonidine inhibits the reaction [CFTR protein affects the transport of Chlorides]

NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767

G

catechol-O-methyltransferase

increases expression

Clonidine results in increased expression of COMT mRNA

NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602

G

C-X-C motif chemokine ligand 15

multiple interactions

Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 protein]

PMID:12065299 PMID:12107048

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

cytochrome P450, family 2, subfamily d, polypeptide 22

increases metabolic processing
multiple interactions

CYP2D6 protein results in increased metabolism of Clonidine
[[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine

NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461

G

FBJ osteosarcoma oncogene

multiple interactions

Clonidine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein]

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

galanin and GMAP prepropeptide

increases activity

Clonidine results in increased activity of GAL protein

NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544

G

growth hormone

increases secretion
multiple interactions
increases expression

Clonidine results in increased secretion of GH1 protein
Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]
Clonidine results in increased expression of GH1; Clonidine results in increased expression of GH1 protein
L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein]

PMID:707001 PMID:2568210 PMID:3007707 PMID:6150000 PMID:15099682 More...

NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691

G

G protein subunit alpha i1

affects response to substance

GNAI1 affects the susceptibility to Clonidine

NCBI chr 5:18,470,133...18,565,411
Ensembl chr 5:18,470,133...18,565,353

G

G protein subunit alpha i3

affects response to substance

GNAI3 affects the susceptibility to Clonidine

NCBI chr 3:108,014,591...108,053,468
Ensembl chr 3:108,014,596...108,053,462

G

heat shock protein 90, alpha (cytosolic), class A member 1

increases expression

Clonidine results in increased expression of HSP90AA1 mRNA

NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162

G

heat shock protein 1 (chaperonin)

increases expression

Clonidine results in increased expression of HSPD1 mRNA

NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402

G

interferon gamma

multiple interactions

BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interleukin 10

increases secretion

Clonidine results in increased secretion of IL10 protein

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 1 alpha

multiple interactions

BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

G

interleukin 1 beta

multiple interactions

Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]

PMID:12065299 PMID:16192389

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 2

multiple interactions

BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

G

insulin II

decreases secretion

Clonidine results in decreased secretion of INS protein

NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

multiple interactions

Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein]

PMID:12065299 PMID:12107048

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

natriuretic peptide type A

increases expression

Clonidine results in increased expression of NPPA protein

NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536

G

neuropeptide Y

increases expression
decreases expression
multiple interactions

Clonidine results in increased expression of NPY mRNA
Clonidine results in decreased expression of NPY mRNA
Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]

NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487

G

opioid receptor, mu 1

multiple interactions
increases response to substance

[Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine
OPRM1 results in increased susceptibility to Clonidine

NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198

G

programmed cell death 4

decreases expression

Clonidine results in decreased expression of PDCD4 mRNA

NCBI chr19:53,880,662...53,926,024
Ensembl chr19:53,880,662...53,918,291

G

pro-opiomelanocortin-alpha

increases expression
multiple interactions
decreases expression
increases secretion

Clonidine results in increased expression of POMC protein
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone
Clonidine results in decreased expression of POMC protein
Clonidine results in increased secretion of POMC protein alternative form
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Indomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form]

PMID:2455169 PMID:2846107 PMID:3039113 PMID:6089027 PMID:10898105

NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642

G

prolactin

increases expression
multiple interactions

Clonidine results in increased expression of PRL protein
Clonidine inhibits the reaction [Fenfluramine results in increased secretion of PRL protein]

PMID:1678730 PMID:16401171

NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein]

PMID:12065299 PMID:12107048

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

renin 1 structural

increases activity
multiple interactions
decreases expression
decreases activity

Clonidine results in increased activity of REN protein
[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein
Clonidine results in decreased expression of REN protein
Clonidine results in decreased activity of REN protein

PMID:238481 PMID:998518 PMID:3007707 PMID:3913757 PMID:6337028 More...

NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063

G

solute carrier family 22 (organic cation transporter), member 1

multiple interactions

Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]

NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716

G

solute carrier family 22 (organic cation transporter), member 2

multiple interactions

Clonidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

PMID:16263091 PMID:21599003

NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375

G

solute carrier family 22 (organic cation transporter), member 3

multiple interactions

Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]

PMID:9830022 PMID:10966924 PMID:16263091

NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591

G

solute carrier family 47, member 1

multiple interactions

Clonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr11:61,234,226...61,269,668
Ensembl chr11:61,234,227...61,269,171

G

solute carrier family 47, member 2

multiple interactions

Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr11:61,192,453...61,233,686
Ensembl chr11:61,192,457...61,233,686

G

trace amine-associated receptor 1

increases activity
multiple interactions

Clonidine results in increased activity of TAAR1 protein
[Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP

NCBI chr10:23,796,304...23,797,302
Ensembl chr10:23,796,254...23,797,367

G

tyrosine hydroxylase

multiple interactions

[Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine; [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine; Clonidine results in decreased activity of and results in decreased expression of TH protein; Clonidine results in increased activity of and results in increased expression of TH protein

NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865

G

tumor necrosis factor

multiple interactions

BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor, alpha-induced protein 3

increases expression

Clonidine results in increased expression of TNFAIP3 mRNA

NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405

G

tumor protein D52

increases expression

Clonidine results in increased expression of TPD52 mRNA

NCBI chr 3:8,991,590...9,069,824
Ensembl chr 3:8,990,653...9,069,783

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22178
role	22194
biological role	22162
pharmacological role	19771
analgesic	14894
non-narcotic analgesic	14069
clonidine	53
clonidine (imino form)	52
Path 2
Term	Annotations
CHEBI ontology	22178
subatomic particle	22170
composite particle	22170
hadron	22201
baryon	22170
nucleon	22170
atomic nucleus	22170
atom	22170
main group element atom	22104
main group molecular entity	22104
s-block molecular entity	21729
hydrogen molecular entity	21646
hydrides	20758
inorganic hydride	18672
pnictogen hydride	18652
nitrogen hydride	18519
azane	18426
ammonia	18425
organic amino compound	18425
aromatic amine	15714
anilines	14557
substituted aniline	14188
chloroaniline	236
dichloroaniline	223
2,6-dichloroaniline	53
clonidine	53
clonidine (imino form)	52

paths to the root