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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:clonazepam
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Accession:CHEBI:3756 term browser browse the term
Definition:1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Synonyms:related_synonym: 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one;   5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one;   5-(2-chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one;   5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one;   Formula=C15H10ClN3O3;   InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20);   InChIKey=DGBIGWXXNGSACT-UHFFFAOYSA-N;   SMILES=[O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1;   clonazepamum
 alt_id: CHEBI:102465
 xref: Beilstein:759557;   CAS:1622-61-3;   DrugBank:DB01068;   Drug_Central:703;   KEGG:D00280
 xref_mesh: MESH:D002998
 xref: PMID:10633040;   PMID:12213069;   PMID:12873507;   Patent:US3116203;   Patent:US3121076;   Patent:US3335181;   Wikipedia:Clonazepam


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clonazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Clonazepam results in increased expression of BAX protein CTD PMID:17456340 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Clonazepam results in increased expression of BCL2 protein CTD PMID:17456340 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity EXP Clonazepam results in increased activity of CYP2B1 protein CTD PMID:1372805 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Dcx doublecortin decreases expression EXP Clonazepam results in decreased expression of DCX protein CTD PMID:19437554 NCBI chr  X:115,098,675...115,175,515
Ensembl chr  X:115,098,675...115,175,299
JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity EXP Clonazepam results in increased activity of EPHX1 protein CTD PMID:1372805 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Clonazepam binds to and results in increased activity of NR1I2 protein CTD PMID:20024649 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link

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  CHEBI ontology 19816
    role 19764
      biological role 19764
        biophysical role 12642
          membrane transport modulator 12441
            GABA modulator 4655
              clonazepam 6
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  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                carbocyclic compound 18222
                                  benzenoid aromatic compound 17254
                                    benzenes 17010
                                      chlorobenzenes 13342
                                        monochlorobenzenes 9524
                                          clonazepam 6
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