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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:clonazepam
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Accession:CHEBI:3756 term browser browse the term
Definition:1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Synonyms:related_synonym: 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one;   5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one;   5-(2-chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one;   5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one;   Formula=C15H10ClN3O3;   InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20);   InChIKey=DGBIGWXXNGSACT-UHFFFAOYSA-N;   SMILES=[O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1;   clonazepamum
 alt_id: CHEBI:102465
 xref: Beilstein:759557;   CAS:1622-61-3;   DrugBank:DB01068;   Drug_Central:703;   KEGG:D00280
 xref_mesh: MESH:D002998
 xref: PMID:10633040;   PMID:12213069;   PMID:12873507;   Patent:US3116203;   Patent:US3121076;   Patent:US3335181;   Wikipedia:Clonazepam



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clonazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Clonazepam results in increased expression of BAX protein CTD PMID:17456340 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Clonazepam results in increased expression of BCL2 protein CTD PMID:17456340 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity EXP Clonazepam results in increased activity of CYP2B1 protein CTD PMID:1372805 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Dcx doublecortin decreases expression EXP Clonazepam results in decreased expression of DCX protein CTD PMID:19437554 NCBI chr  X:107,430,767...107,573,612
Ensembl chr  X:107,430,767...107,507,476
JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity EXP Clonazepam results in increased activity of EPHX1 protein CTD PMID:1372805 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Clonazepam binds to and results in increased activity of NR1I2 protein CTD PMID:20024649 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link

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  CHEBI ontology 19740
    role 19713
      biological role 19711
        biophysical role 13803
          membrane transport modulator 13639
            GABA modulator 4874
              clonazepam 6
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  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic molecule 19587
                              organic cyclic compound 19393
                                carbocyclic compound 18510
                                  benzenoid aromatic compound 17839
                                    benzenes 17680
                                      chlorobenzenes 14397
                                        monochlorobenzenes 11130
                                          clonazepam 6
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