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ONTOLOGY REPORT - ANNOTATIONS


Term:clonazepam
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Accession:CHEBI:3756 term browser browse the term
Definition:1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Synonyms:related_synonym: 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one;   5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one;   5-(2-chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one;   5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one;   Formula=C15H10ClN3O3;   InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20);   InChIKey=DGBIGWXXNGSACT-UHFFFAOYSA-N;   SMILES=[O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1;   clonazepamum
 alt_id: CHEBI:102465
 xref: Beilstein:759557 "Beilstein";   CAS:1622-61-3 "ChemIDplus";   CAS:1622-61-3 "KEGG DRUG";   DrugBank:DB01068;   Drug_Central:703 "DrugCentral";   KEGG:D00280
 xref_mesh: MESH:D002998
 xref: PMID:10633040 "ChEMBL";   PMID:12213069 "ChEMBL";   PMID:12873507 "ChEMBL";   Patent:US3116203;   Patent:US3121076;   Patent:US3335181;   Wikipedia:Clonazepam


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Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6480464
G Dcx doublecortin JBrowse link X 115,098,675 115,175,515 RGD:6480464
G Ephx1 epoxide hydrolase 1 JBrowse link 13 99,271,390 99,300,580 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464

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  CHEBI ontology 19654
    role 19598
      biological role 19596
        biophysical role 12118
          membrane transport modulator 11882
            GABA modulator 4634
              clonazepam 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic molecule 19327
                              organic cyclic compound 19076
                                carbocyclic compound 17501
                                  benzenoid aromatic compound 17022
                                    benzenes 16737
                                      chlorobenzenes 12573
                                        monochlorobenzenes 8721
                                          clonazepam 6
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