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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aryl dialkyl phosphate
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Accession:CHEBI:37558 term browser browse the term
Definition:Any aryl phosphate having a single aryl substituent and two alkyl substituents.
Synonyms:related_synonym: Formula=O4PR3;   SMILES=P(=O)(O*)(O*)O*;   an aryl dialkyl phosphate;   aryl dialkyl phosphates
 alt_id: CHEBI:13249;   CHEBI:22642;   CHEBI:2859
 xref: KEGG:C03254



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paraoxon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO Paraoxon results in decreased expression of ABCA1 protein CTD PMID:25250848 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Acbd5 acyl-CoA binding domain containing 5 increases expression ISO Paraoxon results in increased expression of ACBD5 mRNA CTD PMID:24413757 NCBI chr17:85,206,178...85,248,909
Ensembl chr17:85,206,303...85,248,215
JBrowse link
G Ache acetylcholinesterase increases phosphorylation
decreases activity
multiple interactions
increases activity
increases acylation
decreases expression
increases expression
ISO
EXP
Paraoxon results in increased phosphorylation of ACHE protein
Paraoxon results in decreased activity of ACHE protein; Paraoxon results in decreased activity of ACHE protein mutant form
1,4-bis(2-hydroxyiminomethylpyridinium)butane inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Ranitidine affects the reaction [Paraoxon results in decreased activity of ACHE protein]; Trimedoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]
Paraoxon results in increased activity of ACHE protein
Paraoxon results in increased acylation of ACHE protein
Paraoxon results in decreased expression of ACHE mRNA
ACHE protein inhibits the reaction [Paraoxon results in decreased expression of MCL1 polyA tail]; ACHE protein inhibits the reaction [Paraoxon results in increased abundance of Corticosterone]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]; BCHE protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; coumarin inhibits the reaction [Paraoxon results in increased phosphorylation of ACHE protein]; Gallamine Triethiodide promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]; HLo 7 inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Paraoxon results in increased phosphorylation of and results in decreased activity of ACHE protein; Propidium promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]
1,3-bis(2-hydroxyiminomethylpyridinium)propane inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1,4-bis(2-hydroxyiminomethylpyridinium)butane inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1-((4-(aminocarbonyl)pyridinio)trimethylene)-2-((hydroxyimino)methyl)pyridinium inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 4-(aminocarbonyl)-1-(3-(4-((E)-(hydroxyimino)methyl)pyridinium-1-yl)propyl)pyridinium dibromide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 4-amino-2-((diethylamino)methyl)phenol analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Paraoxon co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Polyethylene Glycols binds to PON1 protein] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Amodiaquine analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; asoxime chloride affects the reaction [Paraoxon results in decreased activity of ACHE protein]; asoxime chloride inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]; BCHE protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Cholinesterase Reactivators inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; diacetylmonoxime inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; Fullerenes analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Glucosides inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; HS 3 inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; isonitrosoacetone inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; isonitrosoacetone inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; K075 compound inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; K117 compound inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; K127 compound inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; methamidophos promotes the reaction [Paraoxon results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Paraoxon binds to and results in decreased activity of ACHE protein; Paraoxon promotes the reaction [methamidophos results in decreased activity of ACHE protein]; Paraoxon results in decreased expression of and results in decreased activity of ACHE protein; PON1 protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein mutant form]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pyridine-2-aldoxime analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pyridine-4-aldoxime analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pyridine-4-aldoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pyridoxaloxime analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Ranitidine inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; RS194B analog inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; RS194B inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; RS41A inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; Tiapamil Hydrochloride inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Trimedoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; trimethylene-bis(4-hydroxyiminomethylpyridinium) inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]
CTD PMID:1609424 PMID:4859365 PMID:8134223 PMID:8783813 PMID:9268605 More... NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Actb actin, beta increases expression ISO Paraoxon results in increased expression of ACTB protein CTD PMID:20931991 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Paraoxon results in increased expression of AHR mRNA CTD PMID:18519978 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akap12 A-kinase anchoring protein 12 decreases expression ISO Paraoxon results in decreased expression of AKAP12 mRNA CTD PMID:24413757 NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886
JBrowse link
G Alb albumin affects binding
increases hydrolysis
multiple interactions
decreases response to substance
ISO Paraoxon binds to ALB protein
ALB protein results in increased hydrolysis of Paraoxon
ALB protein results in decreased susceptibility to [Paraoxon results in decreased activity of BCHE protein]
ALB protein results in decreased susceptibility to Paraoxon
CTD PMID:15525694 PMID:20211614 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Amot angiomotin decreases expression ISO Paraoxon results in decreased expression of AMOT mRNA CTD PMID:27117976 NCBI chr  X:108,982,399...109,041,265
Ensembl chr  X:108,984,022...109,041,272
JBrowse link
G Apeh acylaminoacyl-peptide hydrolase affects binding ISO Paraoxon binds to APEH protein CTD PMID:31872761 NCBI chr 8:108,773,791...108,782,903
Ensembl chr 8:108,773,794...108,782,933
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO Paraoxon results in increased expression of ARHGDIA protein CTD PMID:20931991 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression ISO Paraoxon results in increased expression of ATP5F1B protein CTD PMID:20931991 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Axin2 axin 2 decreases expression ISO Paraoxon results in decreased expression of AXIN2 mRNA CTD PMID:24413757 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane analog inhibits the reaction [Paraoxon results in increased expression of and affects the localization of BAX protein]; Paraoxon results in increased expression of and affects the localization of BAX protein
Paraoxon results in increased expression of BAX mRNA; Paraoxon results in increased expression of BAX protein
CTD PMID:12831782 PMID:28603072 PMID:31493121 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases response to substance
decreases activity
affects binding
ISO
EXP
ALB protein results in decreased susceptibility to [Paraoxon results in decreased activity of BCHE protein]; Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; asoxime chloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; BCHE protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; BCHE protein inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Glucosides inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of BCHE protein]; Obidoxime Chloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Paraoxon binds to and results in decreased activity of BCHE protein; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; pyridine-4-aldoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; pyridoxaloxime analog inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Ranitidine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Tiapamil Hydrochloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Trimedoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]
BCHE protein results in decreased susceptibility to Paraoxon
Paraoxon binds to BCHE protein; Paraoxon binds to BCHE protein modified form
Paraoxon results in decreased activity of BCHE mRNA; Paraoxon results in decreased activity of BCHE protein
CTD PMID:4631366 PMID:12518340 PMID:12629810 PMID:15669026 PMID:16193528 More... NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO
EXP
Paraoxon results in decreased expression of BCL2 mRNA
Paraoxon results in decreased expression of BCL2 mRNA; Paraoxon results in decreased expression of BCL2 protein
CTD PMID:27117976 PMID:28603072 PMID:31493121 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp12 caspase 12 multiple interactions
increases expression
ISO Egtazic Acid inhibits the reaction [Paraoxon results in increased expression of CASP12 protein]; Heparin inhibits the reaction [Paraoxon results in increased expression of CASP12 protein]; Procaine inhibits the reaction [Paraoxon results in increased expression of CASP12 protein] CTD PMID:20079824 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions
ISO
EXP
Paraoxon results in increased activity of CASP3 protein
Paraoxon results in increased expression of CASP3 mRNA; Paraoxon results in increased expression of CASP3 protein
Cyclosporine inhibits the reaction [Paraoxon results in increased activity of CASP3 protein]
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane analog inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Paraoxon results in increased activity of and results in increased cleavage of CASP3 protein]; Paraoxon results in increased activity of and results in increased cleavage of CASP3 protein; Paraoxon results in increased cleavage of and results in increased activity of CASP3 protein
Ro 31-8220 inhibits the reaction [Paraoxon results in increased activity of CASP3 protein]
CTD PMID:11032765 PMID:12831782 PMID:17561261 PMID:29027213 PMID:31493121 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane analog inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein]; Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:12831782 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP9 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane analog inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP9 protein]; Paraoxon results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:12831782 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccdc177 coiled-coil domain containing 177 decreases expression ISO Paraoxon results in decreased expression of CCDC177 mRNA CTD PMID:24413757 NCBI chr 6:100,400,010...100,411,221
Ensembl chr 6:100,404,413...100,412,850
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 increases expression ISO Paraoxon results in increased expression of CCR6 mRNA CTD PMID:24413757 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
JBrowse link
G Ces1d carboxylesterase 1D decreases activity
affects binding
ISO Paraoxon results in decreased activity of CES1 protein
Paraoxon binds to CES1 protein
CTD PMID:11950785 PMID:25250848 PMID:31872761 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Paraoxon results in decreased activity of CES2 protein CTD PMID:11950785 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Ces3a carboxylesterase 3a decreases activity ISO Paraoxon results in decreased activity of CES3 protein CTD PMID:11950785 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression ISO Paraoxon results in decreased expression of CHRM1 mRNA CTD PMID:21787676 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases expression ISO Paraoxon results in decreased expression of CHRM2 mRNA CTD PMID:21787676 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 decreases expression ISO Paraoxon results in decreased expression of CHRM3 mRNA CTD PMID:21787676 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
decreases expression
EXP Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]; Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]; Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]
Paraoxon results in decreased expression of CHRNA4 mRNA; Paraoxon results in decreased expression of CHRNA4 protein
CTD PMID:21791372 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
decreases expression
EXP Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]; Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]; Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]
Paraoxon results in decreased expression of CHRNB2 mRNA; Paraoxon results in decreased expression of CHRNB2 protein
CTD PMID:21791372 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Clk1 CDC-like kinase 1 increases expression ISO Paraoxon results in increased expression of CLK1 mRNA CTD PMID:22093924 NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000
JBrowse link
G Clk3 CDC-like kinase 3 increases expression ISO Paraoxon results in increased expression of CLK3 mRNA CTD PMID:22093924 NCBI chr 8:58,152,155...58,167,196
Ensembl chr 8:58,152,155...58,168,181
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
decreases activity
ISO Paraoxon inhibits the reaction [CP 55244 binds to CNR1 protein]
Paraoxon results in decreased activity of CNR1 protein
CTD PMID:12243867 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Paraoxon inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA] CTD PMID:24555085 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Eno1 enolase 1 decreases expression ISO Paraoxon results in decreased expression of ENO1 protein CTD PMID:20931991 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Paraoxon results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G F2 coagulation factor II increases activity
multiple interactions
ISO Paraoxon results in increased activity of F2 protein
[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein
CTD PMID:30515700 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions ISO [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein CTD PMID:30515700 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G Faah fatty acid amide hydrolase decreases activity EXP Paraoxon results in decreased activity of FAAH protein CTD PMID:25447325 NCBI chr 5:129,479,774...129,499,018 JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases expression ISO Paraoxon results in decreased expression of FGFR1 mRNA CTD PMID:24413757 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA] CTD PMID:21787676 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gap43 growth associated protein 43 decreases expression ISO Paraoxon results in decreased expression of GAP43 protein CTD PMID:27939611 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Paraoxon results in increased expression of GCLM mRNA CTD PMID:24413757 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gss glutathione synthetase increases expression ISO Paraoxon results in increased expression of GSS CTD PMID:24486155 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO Paraoxon results in increased expression of GSTM2 CTD PMID:24486155 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstt2 glutathione S-transferase, theta 2 increases expression ISO Paraoxon results in increased expression of GSTT2 CTD PMID:24486155 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
JBrowse link
G H2ac12 H2A clustered histone 12 decreases expression ISO Paraoxon results in decreased expression of H2AC12 protein CTD PMID:20931991 NCBI chr17:42,486,315...42,486,880 JBrowse link
G H2ac4 H2A clustered histone 4 decreases expression ISO Paraoxon results in decreased expression of H2AC4 mRNA CTD PMID:24413757 NCBI chr17:42,799,953...42,800,345
Ensembl chr17:42,799,652...42,800,381
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C increases expression ISO Paraoxon results in increased expression of HNRNPC protein CTD PMID:20931991 NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression ISO Paraoxon results in decreased expression of HSP90AA1 protein CTD PMID:20931991 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO Paraoxon results in decreased expression of HSP90AB1 protein CTD PMID:20931991 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Paraoxon results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 decreases expression ISO Paraoxon results in decreased expression of IL6 mRNA CTD PMID:22093924 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ildr1 immunoglobulin-like domain containing receptor 1 increases expression ISO Paraoxon results in increased expression of ILDR1 mRNA CTD PMID:24413757 NCBI chr11:64,085,774...64,118,760
Ensembl chr11:64,008,566...64,118,760
JBrowse link
G Ilf2 interleukin enhancer binding factor 2 increases expression ISO Paraoxon results in increased expression of ILF2 protein CTD PMID:20931991 NCBI chr 2:175,951,002...175,971,193
Ensembl chr 2:175,952,186...175,971,337
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Paraoxon results in decreased expression of JUN mRNA CTD PMID:27117976 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kirrel2 kirre like nephrin family adhesion molecule 2 increases expression ISO Paraoxon results in increased expression of KIRREL2 mRNA CTD PMID:24413757 NCBI chr 1:85,708,793...85,718,670
Ensembl chr 1:85,708,793...85,718,670
JBrowse link
G Lat2 linker for activation of T cells family, member 2 increases expression ISO Paraoxon results in increased expression of LAT2 mRNA CTD PMID:24413757 NCBI chr12:22,104,163...22,118,294
Ensembl chr12:22,104,219...22,118,288
JBrowse link
G Lipa lipase A, lysosomal acid type decreases activity ISO Paraoxon results in decreased activity of LIPA protein CTD PMID:25250848 NCBI chr 1:232,024,351...232,167,329
Ensembl chr 1:232,024,356...232,057,633
JBrowse link
G Lmnb2 lamin B2 increases expression ISO Paraoxon results in increased expression of LMNB2 protein CTD PMID:20931991 NCBI chr 7:8,792,628...8,808,665
Ensembl chr 7:8,789,314...8,808,665
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression
increases expression
ISO ACHE protein inhibits the reaction [Paraoxon results in decreased expression of MCL1 polyA tail]
Paraoxon results in increased expression of MCL1 protein alternative form
CTD PMID:22093924 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Paraoxon results in decreased activity of NCEH1 protein CTD PMID:16449251 PMID:16978018 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
JBrowse link
G Nefh neurofilament heavy chain decreases expression ISO Paraoxon results in decreased expression of NEFH protein CTD PMID:27939611 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nes nestin increases expression ISO Paraoxon results in increased expression of NES mRNA CTD PMID:27117976 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [NR1I3 protein affects the metabolism of Parathion] which affects the chemical synthesis of Paraoxon CTD PMID:20573718 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Paraoxon results in increased expression of ORM1 mRNA CTD PMID:17497759 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Paraoxon results in increased cleavage of PARP1 protein
Metoclopramide inhibits the reaction [Paraoxon results in increased cleavage of PARP1 protein]
CTD PMID:29027213 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 increases expression ISO Paraoxon results in increased expression of PARP4 mRNA CTD PMID:24413757 NCBI chr15:30,690,503...30,792,868 JBrowse link
G Pcnx4 pecanex 4 increases expression ISO Paraoxon results in increased expression of PCNX4 mRNA CTD PMID:24413757 NCBI chr 6:91,125,063...91,170,423 JBrowse link
G Pdgfa platelet derived growth factor subunit A increases expression ISO Paraoxon results in increased expression of PDGFA mRNA CTD PMID:30978295 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Phb1 prohibitin 1 decreases expression ISO Paraoxon results in decreased expression of PHB protein CTD PMID:20931991 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
JBrowse link
G Pnliprp2 pancreatic lipase related protein 2 decreases activity ISO
EXP
Paraoxon results in decreased activity of PNLIPRP2 protein CTD PMID:9822688 PMID:17401110 NCBI chr 1:257,897,766...257,916,434
Ensembl chr 1:257,897,766...257,916,434
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 multiple interactions
decreases activity
ISO [Paraoxon co-treated with mipafox] results in decreased activity of PNPLA6 protein
Paraoxon results in decreased activity of PNPLA6 protein
CTD PMID:9268605 PMID:19620706 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734
JBrowse link
G Pon1 paraoxonase 1 increases activity
decreases response to substance
multiple interactions
increases hydrolysis
affects metabolic processing
increases metabolic processing
affects response to substance
affects hydrolysis
ISO
EXP
Paraoxon results in increased activity of PON1 protein
PON1 results in decreased susceptibility to Paraoxon
[Alendronate results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to Paraoxon; [Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Paraoxon; [Ibandronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Risedronic Acid results in increased activity of PON1 protein] which results in increased metabolism of Paraoxon; Fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]
2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; [Ascorbic Acid co-treated with Copper Sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; [Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to Paraoxon; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Paraoxon; [Polyethylene Glycols binds to PON1 protein] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Polyethylene Glycols binds to PON1 protein] which results in increased hydrolysis of Paraoxon; Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Calcium Chloride promotes the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Hydrogen Peroxide inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; lysophosphatidylglycerol inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; lysophosphatidylinositol inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Oleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Oxygen promotes the reaction [PON1 protein affects the metabolism of Paraoxon]; palmitoleic acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; PON1 protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; PON1 protein polymorphism affects the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]
PON1 protein mutant form results in increased hydrolysis of Paraoxon; PON1 protein results in increased hydrolysis of Paraoxon
PON1 protein mutant form results in decreased susceptibility to Paraoxon
PON1 protein affects the metabolism of Paraoxon; PON1 protein polymorphism affects the metabolism of Paraoxon
PON1 protein results in increased metabolism of Paraoxon
PON1 gene polymorphism affects the susceptibility to Paraoxon
PON1 3' UTR SNP affects the hydrolysis of Paraoxon; PON1 intron SNP affects the hydrolysis of Paraoxon; PON1 protein polymorphism affects the hydrolysis of Paraoxon
CTD PMID:9313934 PMID:9746266 PMID:11022865 PMID:11304470 PMID:14668577 More... NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta increases expression ISO Paraoxon results in increased expression of PTK2B mRNA CTD PMID:24413757 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Set SET nuclear proto-oncogene increases expression ISO Paraoxon results in increased expression of SET mRNA CTD PMID:24413757 NCBI chr19:53,561,262...53,562,780
Ensembl chr19:53,561,190...53,563,819
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases expression EXP Paraoxon results in decreased expression of SLC1A1 mRNA; Paraoxon results in decreased expression of SLC1A1 protein CTD PMID:28603072 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Slc1a2 solute carrier family 1 member 2 increases expression
affects expression
EXP Paraoxon results in increased expression of SLC1A2 mRNA; Paraoxon results in increased expression of SLC1A2 protein
Paraoxon affects the expression of SLC1A2 mRNA; Paraoxon affects the expression of SLC1A2 protein
CTD PMID:27769869 PMID:28603072 NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
JBrowse link
G Slc1a3 solute carrier family 1 member 3 increases expression
affects expression
EXP Paraoxon results in increased expression of SLC1A3 mRNA; Paraoxon results in increased expression of SLC1A3 protein
Paraoxon affects the expression of SLC1A3 mRNA; Paraoxon affects the expression of SLC1A3 protein
CTD PMID:27769869 PMID:28603072 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Paraoxon results in increased expression of SOD2 CTD PMID:24486155 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Syn1 synapsin I decreases expression ISO Paraoxon results in decreased expression of SYN1 protein CTD PMID:27939611 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396
JBrowse link
G Syp synaptophysin decreases expression ISO Paraoxon results in decreased expression of SYP protein CTD PMID:27939611 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Paraoxon results in increased expression of TGFB1 mRNA CTD PMID:30978295 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression
ISO Paraoxon results in decreased expression of TNF mRNA
Paraoxon results in increased expression of TNF mRNA
CTD PMID:22093924 PMID:30978295 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Paraoxon results in increased expression of TRP53 protein
benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane analog inhibits the reaction [Paraoxon results in increased expression of TRP53 protein]
CTD PMID:12831782 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpm4 tropomyosin 4 increases expression ISO Paraoxon results in increased expression of TPM4 protein CTD PMID:20931991 NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984
JBrowse link
G Ttc16 tetratricopeptide repeat domain 16 increases expression ISO Paraoxon results in increased expression of TTC16 mRNA CTD PMID:24413757 NCBI chr 3:16,048,484...16,064,598
Ensembl chr 3:16,048,565...16,064,547
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial increases expression ISO Paraoxon results in increased expression of TUFM protein CTD PMID:20931991 NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
JBrowse link
G Ube2z ubiquitin-conjugating enzyme E2Z decreases expression ISO Paraoxon results in decreased expression of UBE2Z mRNA CTD PMID:24413757 NCBI chr10:80,997,816...81,016,936
Ensembl chr10:80,997,817...81,016,936
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Paraoxon results in decreased expression of VEGFA mRNA CTD PMID:27117976 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Yap1 Yes1 associated transcriptional regulator decreases expression ISO Paraoxon results in decreased expression of YAP1 mRNA CTD PMID:24413757 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
JBrowse link
G Yy2 YY2 transcription factor increases expression ISO Paraoxon results in increased expression of YY2 mRNA CTD PMID:24413757 NCBI chr  X:37,438,425...37,442,047 JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO Paraoxon results in increased expression of ZFP36 mRNA CTD PMID:22093924 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
JBrowse link
G Zfyve19 zinc finger FYVE-type containing 19 increases expression ISO Paraoxon results in increased expression of ZFYVE19 protein CTD PMID:20931991 NCBI chr 3:106,195,779...106,203,969
Ensembl chr 3:106,195,899...106,203,969
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        solvent 16635
          phosphoric acid 8536
            phosphoric acid derivative 8242
              organic phosphate 8241
                aryl phosphate 1192
                  aryl dialkyl phosphate 93
                    diethyl phenyl phosphate 0
                    paraoxon 93
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      chalcogen 19450
                        oxygen atom 19423
                          oxygen molecular entity 19423
                            hydroxides 19158
                              oxoacid 18472
                                pnictogen oxoacid 10733
                                  phosphorus oxoacid 9728
                                    phosphoric acids 8536
                                      phosphoric acid 8536
                                        phosphoric acid derivative 8242
                                          phosphate 8242
                                            organic phosphate 8241
                                              alkyl phosphate 4125
                                                dialkyl phosphate 3442
                                                  aryl dialkyl phosphate 93
                                                    diethyl phenyl phosphate 0
                                                    paraoxon 93
paths to the root