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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sphingosine 1-phosphate
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Accession:CHEBI:37550 term browser browse the term
Definition:A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
Synonyms:exact_synonym: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
 related_synonym: (2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid;   (2S,3R,4E)-2-amino-4-octadecene-1,3-diol 1-(dihydrogen phosphate);   C18-Sphingosine 1-phosphate;   D-erythro-sphingosine 1-phosphate;   Formula=C18H38NO5P;   InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1;   InChIKey=DUYSYHSSBDVJSM-KRWOKUGFSA-N;   S1P;   SMILES=CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@@H](N)COP(O)(O)=O;   Sphing-4-enine 1-phosphate;   Sphingosine 1-phosphic acid
 alt_id: CHEBI:26742;   CHEBI:9225
 xref: Beilstein:5877213;   CAS:26993-30-6;   HMDB:HMDB0000277;   KEGG:C06124;   LIPID_MAPS_instance:LMSP01050001
 xref_mesh: MESH:C060506
 xref: PMID:11278407;   PMID:11324700;   PMID:11331099;   PMID:11418470;   PMID:11470796;   PMID:11739995;   PMID:12039947;   PMID:12062172;   PMID:12069819;   PMID:12069830;   PMID:12401202;   PMID:12509810;   PMID:12586615;   PMID:12730100;   PMID:12742827;   PMID:12746430;   PMID:12778803;   PMID:12833634;   PMID:12963123;   PMID:12963813;   PMID:15044318;   PMID:15143482;   PMID:15158755;   PMID:15258919;   PMID:15292266;   PMID:15317688;   PMID:15326035;   PMID:15354862;   PMID:15476260;   PMID:15567060;   PMID:15696050;   PMID:15728255;   PMID:15734735;   PMID:15761190;   PMID:15778280;   PMID:15992170;   PMID:16046448;   PMID:16129068;   PMID:16162874;   PMID:16243846;   PMID:16322129;   PMID:16339142;   PMID:16434032;   PMID:16554657;   PMID:16913663;   PMID:16940153;   PMID:16956968;   PMID:17098744;   PMID:17158356;   PMID:17220911;   PMID:17308123;   PMID:17361098;   PMID:17374154;   PMID:17391120;   PMID:17409372;   PMID:17517398;   PMID:17561264;   PMID:17904858;   PMID:18155002;   PMID:18387885;   PMID:18502612;   PMID:18541717;   PMID:18787560;   PMID:18973762;   PMID:19081473;   PMID:19082500;   PMID:19268560;   PMID:19293152;   PMID:19350109;   PMID:19423865;   PMID:19556602;   PMID:19620297;   PMID:19636535;   PMID:19662499;   PMID:19808013;   PMID:19815502;   Reaxys:5877213;   Wikipedia:Sphingosine-1-phosphate
 cyclic_relationship: is_conjugate_acid_of CHEBI:60119


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sphingosine 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions
increases expression		 ISO sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ACTA2 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ACTA2 protein]
sphingosine 1-phosphate results in increased expression of ACTA2 mRNA; sphingosine 1-phosphate results in increased expression of ACTA2 protein		 CTD PMID:37169277 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 EXP
ISO		 sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of AKT1 protein
sphingosine 1-phosphate results in increased phosphorylation of AKT1 protein		 CTD PMID:15946935 PMID:16365044 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G ATG5 autophagy related 5 multiple interactions
increases expression		 ISO 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of ATG5 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of ATG5 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ATG5 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ATG5 protein]
sphingosine 1-phosphate results in increased expression of ATG5 mRNA; sphingosine 1-phosphate results in increased expression of ATG5 protein		 CTD PMID:37169277 NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression
multiple interactions		 EXP sphingosine 1-phosphate results in decreased expression of BAX mRNA
sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]		 CTD PMID:24399507 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein] CTD PMID:24399507 PMID:24420784 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BECN1 beclin 1 increases expression
multiple interactions		 ISO sphingosine 1-phosphate results in increased expression of BECN1 mRNA; sphingosine 1-phosphate results in increased expression of BECN1 protein
sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of BECN1 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of BECN1 protein]		 CTD PMID:37169277 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G CASP1 caspase 1 multiple interactions ISO sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of and results in increased cleavage of CASP1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of CASP1 mRNA] CTD PMID:37169277 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CCN2 cellular communication network factor 2 increases expression ISO
EXP		 sphingosine 1-phosphate results in increased expression of CCN2 mRNA CTD PMID:25690654 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions
increases expression		 ISO 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of COL1A1 mRNA]
sphingosine 1-phosphate results in increased expression of COL1A1 mRNA; sphingosine 1-phosphate results in increased expression of COL1A1 protein		 CTD PMID:37169277 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions		 EXP sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]		 CTD PMID:18612546 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases expression		 EXP 1-Butanol inhibits the reaction [sphingosine 1-phosphate results in increased expression of CXCL8 mRNA]; Dactinomycin inhibits the reaction [sphingosine 1-phosphate results in increased expression of CXCL8 mRNA]; Pertussis Toxin inhibits the reaction [sphingosine 1-phosphate results in increased expression of CXCL8 protein]
sphingosine 1-phosphate results in increased expression of CXCL8 mRNA; sphingosine 1-phosphate results in increased expression of CXCL8 protein		 CTD PMID:12039947 PMID:19349368 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CXCR1 C-X-C motif chemokine receptor 1 decreases expression EXP sphingosine 1-phosphate results in decreased expression of CXCR1 mRNA CTD PMID:16224106 NCBI chr 2:218,162,841...218,166,962
Ensembl chr 2:218,162,841...218,166,962 		JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 increases expression EXP sphingosine 1-phosphate results in increased expression of CYP17A1 mRNA CTD PMID:15666826 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472 		JBrowse link
G EGFR epidermal growth factor receptor increases phosphorylation
multiple interactions		 EXP sphingosine 1-phosphate results in increased phosphorylation of EGFR protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of EGFR protein]		 CTD PMID:26518876 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G FN1 fibronectin 1 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; SB 203580 inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of FN1 protein] CTD PMID:21998146 PMID:22406263 PMID:37169277 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G GNAQ G protein subunit alpha q multiple interactions
increases expression		 EXP Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein] CTD PMID:25980589 NCBI chr 9:77,716,097...78,031,811
Ensembl chr 9:77,716,097...78,031,811 		JBrowse link
G GSK3A glycogen synthase kinase 3 alpha multiple interactions EXP sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]; Wortmannin inhibits the reaction [sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]] CTD PMID:25769802 NCBI chr19:42,230,190...42,242,602
Ensembl chr19:42,226,225...42,242,625 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions EXP sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; Wortmannin affects the reaction [sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]] CTD PMID:25769802 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G HGF hepatocyte growth factor increases expression EXP sphingosine 1-phosphate results in increased expression of HGF mRNA CTD PMID:19349368 NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438 		JBrowse link
G HRK harakiri, BCL2 interacting protein multiple interactions EXP sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA] CTD PMID:24399507 PMID:24420784 NCBI chr12:116,856,144...116,881,441
Ensembl chr12:116,856,144...116,881,441 		JBrowse link
G HSF1 heat shock transcription factor 1 increases activity EXP sphingosine 1-phosphate results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720 		JBrowse link
G IGF1 insulin like growth factor 1 increases expression EXP sphingosine 1-phosphate results in increased expression of IGF1 mRNA CTD PMID:19349368 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IL18 interleukin 18 multiple interactions ISO 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of IL18 protein] CTD PMID:37169277 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL1B interleukin 1 beta increases secretion
multiple interactions
increases expression		 EXP sphingosine 1-phosphate results in increased secretion of IL1B protein
Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]; S1PR1 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]		 CTD PMID:32401414 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression		 EXP JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL6 mRNA] CTD PMID:26518876 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G JAK2 Janus kinase 2 increases phosphorylation EXP sphingosine 1-phosphate results in increased phosphorylation of JAK2 protein CTD PMID:32401414 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948 		JBrowse link
G KDR kinase insert domain receptor multiple interactions EXP sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA] CTD PMID:15741222 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G LAMA3 laminin subunit alpha 3 increases expression EXP sphingosine 1-phosphate results in increased expression of LAMA3 mRNA CTD PMID:15541073 NCBI chr18:23,689,453...23,955,066
Ensembl chr18:23,689,453...23,956,222 		JBrowse link
G LAMB3 laminin subunit beta 3 increases expression EXP sphingosine 1-phosphate results in increased expression of LAMB3 mRNA CTD PMID:15541073 NCBI chr 1:209,614,870...209,652,425
Ensembl chr 1:209,614,870...209,652,425 		JBrowse link
G LAMC2 laminin subunit gamma 2 increases expression EXP sphingosine 1-phosphate results in increased expression of LAMC2 mRNA CTD PMID:15541073 NCBI chr 1:183,186,264...183,258,968
Ensembl chr 1:183,186,238...183,245,127 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions
increases expression		 ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of MAP1LC3B mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein
sphingosine 1-phosphate results in increased expression of MAP1LC3B mRNA		 CTD PMID:37169277 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP
ISO		 JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK1 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form		 CTD PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP
ISO		 JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK3 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form		 CTD PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
increases expression		 EXP JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 protein]
sphingosine 1-phosphate results in increased expression of MMP2 mRNA; sphingosine 1-phosphate results in increased expression of MMP2 protein		 CTD PMID:26518876 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
increases expression		 EXP Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]
sphingosine 1-phosphate results in increased expression of MMP9 mRNA; sphingosine 1-phosphate results in increased expression of MMP9 protein		 CTD PMID:25980589 PMID:26518876 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of NLRP3 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of NLRP3 protein] CTD PMID:37169277 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108 		JBrowse link
G NRP1 neuropilin 1 multiple interactions EXP sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr10:33,177,493...33,334,667
Ensembl chr10:33,177,492...33,336,262 		JBrowse link
G NRP2 neuropilin 2 multiple interactions EXP sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 2:205,682,501...205,798,131
Ensembl chr 2:205,681,990...205,798,133 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 increases expression ISO sphingosine 1-phosphate results in increased expression of PECAM1 protein CTD PMID:19349368 NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776 		JBrowse link
G PLCB4 phospholipase C beta 4 increases expression
multiple interactions		 EXP sphingosine 1-phosphate results in increased expression of PLCB4 protein
Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]		 CTD PMID:25980589 NCBI chr20:9,068,678...9,480,808
Ensembl chr20:9,067,825...9,504,593 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO [Bezafibrate results in increased activity of PPARA protein] which results in decreased abundance of sphingosine 1-phosphate CTD PMID:18024222 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; MK 2206 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]
sphingosine 1-phosphate results in increased expression of PTGS2 mRNA; sphingosine 1-phosphate results in increased expression of PTGS2 protein		 CTD PMID:18612546 PMID:26518876 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization		 EXP JTE 013 inhibits the reaction [sphingosine 1-phosphate affects the localization of RELA protein modified form] CTD PMID:26518876 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G S1PR1 sphingosine-1-phosphate receptor 1 increases response to substance
affects binding
multiple interactions
increases expression		 ISO
EXP		 S1PR1 protein results in increased susceptibility to sphingosine 1-phosphate
S1PR1 protein binds to sphingosine 1-phosphate
S1PR1 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]
sphingosine 1-phosphate results in increased expression of S1PR1 mRNA
sphingosine 1-phosphate binds to and results in increased activity of S1PR1 protein		 CTD PMID:20844107 PMID:24399507 PMID:32401414 PMID:35412894 NCBI chr 1:101,236,899...101,242,313
Ensembl chr 1:101,236,865...101,243,713 		JBrowse link
G S1PR2 sphingosine-1-phosphate receptor 2 multiple interactions
increases expression
increases uptake
increases activity		 EXP
ISO		 S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]
sphingosine 1-phosphate results in increased expression of S1PR2 protein
sphingosine 1-phosphate results in increased uptake of S1PR2 protein
sphingosine 1-phosphate results in increased activity of S1PR2 protein
[JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] results in decreased susceptibility to [sphingosine 1-phosphate co-treated with Glucose]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] which results in decreased susceptibility to sphingosine 1-phosphate; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR2 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of S1PR2 protein]		 CTD PMID:18612546 PMID:22406263 PMID:26518876 PMID:37169277 NCBI chr19:10,221,433...10,231,331
Ensembl chr19:10,221,433...10,231,331 		JBrowse link
G S1PR3 sphingosine-1-phosphate receptor 3 multiple interactions
increases expression		 EXP Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] CTD PMID:18612546 PMID:25980589 NCBI chr 9:88,990,863...89,005,155
Ensembl chr 9:88,990,863...89,005,155 		JBrowse link
G S1PR5 sphingosine-1-phosphate receptor 5 multiple interactions EXP Endocannabinoids inhibits the reaction [sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein]; sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein CTD PMID:30102254 NCBI chr19:10,512,742...10,517,965
Ensembl chr19:10,512,742...10,517,931 		JBrowse link
G SMAD3 SMAD family member 3 increases phosphorylation ISO sphingosine 1-phosphate results in increased phosphorylation of SMAD3 protein CTD PMID:37169277 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
G SMPD2 sphingomyelin phosphodiesterase 2 multiple interactions EXP sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein] CTD PMID:15741222 NCBI chr 6:109,440,724...109,443,919
Ensembl chr 6:109,440,724...109,443,919 		JBrowse link
G SPHK1 sphingosine kinase 1 increases chemical synthesis
multiple interactions		 EXP SPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate
[Resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA]; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein]		 CTD PMID:22251058 PMID:24399507 PMID:26045781 NCBI chr17:76,383,204...76,387,855
Ensembl chr17:76,376,584...76,387,860 		JBrowse link
G SPNS2 SPNS lysolipid transporter 2, sphingosine-1-phosphate increases secretion
multiple interactions		 EXP SPNS2 protein results in increased secretion of sphingosine 1-phosphate
TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate]		 CTD PMID:29772789 NCBI chr17:4,498,881...4,539,035
Ensembl chr17:4,498,881...4,539,035 		JBrowse link
G SQSTM1 sequestosome 1 decreases expression ISO sphingosine 1-phosphate results in decreased expression of SQSTM1 protein CTD PMID:37169277 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation		 EXP Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein] CTD PMID:32401414 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G TGFB2 transforming growth factor beta 2 multiple interactions EXP TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate] CTD PMID:29772789 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression		 EXP JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of TNF mRNA]; sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] CTD PMID:18981156 PMID:26518876 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] CTD PMID:18981156 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      biological role 25936
        molecular messenger 20284
          signalling molecule 11008
            sphingosine 1-phosphate 56
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    main group molecular entity 25841
                      s-block molecular entity 25162
                        hydrogen molecular entity 24761
                          hydrides 22973
                            inorganic hydride 20500
                              pnictogen hydride 20441
                                nitrogen hydride 20219
                                  azane 19961
                                    ammonia 19960
                                      organic amino compound 19960
                                        amino alcohol 1083
                                          aminodiol 197
                                            2-aminooctadecene-1,3-diol 145
                                              sphingenine 145
                                                sphing-4-enine 145
                                                  sphingosine 145
                                                    sphingosine 1-phosphate 56
paths to the root