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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sphingosine 1-phosphate
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Accession:CHEBI:37550 term browser browse the term
Definition:A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
Synonyms:exact_synonym: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
 related_synonym: (2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid;   (2S,3R,4E)-2-amino-4-octadecene-1,3-diol 1-(dihydrogen phosphate);   C18-Sphingosine 1-phosphate;   D-erythro-sphingosine 1-phosphate;   Formula=C18H38NO5P;   InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1;   InChIKey=DUYSYHSSBDVJSM-KRWOKUGFSA-N;   S1P;   SMILES=CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@@H](N)COP(O)(O)=O;   Sphing-4-enine 1-phosphate;   Sphingosine 1-phosphic acid
 alt_id: CHEBI:26742;   CHEBI:9225
 xref: Beilstein:5877213;   CAS:26993-30-6;   HMDB:HMDB0000277;   KEGG:C06124;   LIPID_MAPS_instance:LMSP01050001
 xref_mesh: MESH:C060506
 xref: PMID:11278407;   PMID:11324700;   PMID:11331099;   PMID:11418470;   PMID:11470796;   PMID:11739995;   PMID:12039947;   PMID:12062172;   PMID:12069819;   PMID:12069830;   PMID:12401202;   PMID:12509810;   PMID:12586615;   PMID:12730100;   PMID:12742827;   PMID:12746430;   PMID:12778803;   PMID:12833634;   PMID:12963123;   PMID:12963813;   PMID:15044318;   PMID:15143482;   PMID:15158755;   PMID:15258919;   PMID:15292266;   PMID:15317688;   PMID:15326035;   PMID:15354862;   PMID:15476260;   PMID:15567060;   PMID:15696050;   PMID:15728255;   PMID:15734735;   PMID:15761190;   PMID:15778280;   PMID:15992170;   PMID:16046448;   PMID:16129068;   PMID:16162874;   PMID:16243846;   PMID:16322129;   PMID:16339142;   PMID:16434032;   PMID:16554657;   PMID:16913663;   PMID:16940153;   PMID:16956968;   PMID:17098744;   PMID:17158356;   PMID:17220911;   PMID:17308123;   PMID:17361098;   PMID:17374154;   PMID:17391120;   PMID:17409372;   PMID:17517398;   PMID:17561264;   PMID:17904858;   PMID:18155002;   PMID:18387885;   PMID:18502612;   PMID:18541717;   PMID:18787560;   PMID:18973762;   PMID:19081473;   PMID:19082500;   PMID:19268560;   PMID:19293152;   PMID:19350109;   PMID:19423865;   PMID:19556602;   PMID:19620297;   PMID:19636535;   PMID:19662499;   PMID:19808013;   PMID:19815502;   Reaxys:5877213;   Wikipedia:Sphingosine-1-phosphate
 cyclic_relationship: is_conjugate_acid_of CHEBI:60119


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sphingosine 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression		 EXP sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ACTA2 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ACTA2 protein]
sphingosine 1-phosphate results in increased expression of ACTA2 mRNA; sphingosine 1-phosphate results in increased expression of ACTA2 protein		 CTD PMID:37169277 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of AKT1 protein
sphingosine 1-phosphate results in increased phosphorylation of AKT1 protein		 CTD PMID:15946935 PMID:16365044 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions		 EXP sphingosine 1-phosphate results in increased expression of ATG5 mRNA; sphingosine 1-phosphate results in increased expression of ATG5 protein
3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of ATG5 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of ATG5 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ATG5 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ATG5 protein]		 CTD PMID:37169277 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions		 ISO sphingosine 1-phosphate results in decreased expression of BAX mRNA
sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]		 CTD PMID:24399507 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein] CTD PMID:24399507 PMID:24420784 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 EXP sphingosine 1-phosphate results in increased expression of BECN1 mRNA; sphingosine 1-phosphate results in increased expression of BECN1 protein
sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of BECN1 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of BECN1 protein]		 CTD PMID:37169277 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of and results in increased cleavage of CASP1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of CASP1 mRNA] CTD PMID:37169277 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO sphingosine 1-phosphate results in increased expression of CCN2 mRNA CTD PMID:25690654 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions		 EXP sphingosine 1-phosphate results in increased expression of COL1A1 mRNA; sphingosine 1-phosphate results in increased expression of COL1A1 protein
3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of COL1A1 mRNA]		 CTD PMID:37169277 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions		 ISO sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]		 CTD PMID:18612546 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 decreases expression ISO sphingosine 1-phosphate results in decreased expression of CXCR1 mRNA CTD PMID:16224106 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO sphingosine 1-phosphate results in increased expression of CYP17A1 mRNA CTD PMID:15666826 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation
multiple interactions		 ISO sphingosine 1-phosphate results in increased phosphorylation of EGFR protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of EGFR protein]		 CTD PMID:26518876 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Fn1 fibronectin 1 multiple interactions
increases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; SB 203580 inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of FN1 protein] CTD PMID:21998146 PMID:22406263 PMID:37169277 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Gnaq G protein subunit alpha q multiple interactions
increases expression		 ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein] CTD PMID:25980589 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]; Wortmannin inhibits the reaction [sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]] CTD PMID:25769802 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; Wortmannin affects the reaction [sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]] CTD PMID:25769802 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hgf hepatocyte growth factor increases expression ISO sphingosine 1-phosphate results in increased expression of HGF mRNA CTD PMID:19349368 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hrk harakiri, BCL2 interacting protein multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA] CTD PMID:24399507 PMID:24420784 NCBI chr12:38,387,484...38,409,652 JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO sphingosine 1-phosphate results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO sphingosine 1-phosphate results in increased expression of IGF1 mRNA CTD PMID:19349368 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of IL18 protein] CTD PMID:37169277 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
multiple interactions		 ISO sphingosine 1-phosphate results in increased expression of IL1B mRNA
sphingosine 1-phosphate results in increased secretion of IL1B protein
Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]; S1PR1 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]		 CTD PMID:32401414 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL6 mRNA] CTD PMID:26518876 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation ISO sphingosine 1-phosphate results in increased phosphorylation of JAK2 protein CTD PMID:32401414 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA] CTD PMID:15741222 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMA3 mRNA CTD PMID:15541073 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353 		JBrowse link
G Lamb3 laminin subunit beta 3 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMB3 mRNA CTD PMID:15541073 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405 		JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMC2 mRNA CTD PMID:15541073 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 EXP JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of MAP1LC3B mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein
sphingosine 1-phosphate results in increased expression of MAP1LC3B mRNA		 CTD PMID:37169277 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK1 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form		 CTD PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK3 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form		 CTD PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression		 ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 protein]
sphingosine 1-phosphate results in increased expression of MMP2 mRNA; sphingosine 1-phosphate results in increased expression of MMP2 protein		 CTD PMID:26518876 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression		 ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]
sphingosine 1-phosphate results in increased expression of MMP9 mRNA; sphingosine 1-phosphate results in increased expression of MMP9 protein		 CTD PMID:25980589 PMID:26518876 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of NLRP3 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of NLRP3 protein] CTD PMID:37169277 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nrp2 neuropilin 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression ISO sphingosine 1-phosphate results in increased expression of PECAM1 protein CTD PMID:19349368 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Plcb4 phospholipase C, beta 4 increases expression
multiple interactions		 ISO sphingosine 1-phosphate results in increased expression of PLCB4 protein
Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]		 CTD PMID:25980589 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Bezafibrate results in increased activity of PPARA protein] which results in decreased abundance of sphingosine 1-phosphate CTD PMID:18024222 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; MK 2206 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]
sphingosine 1-phosphate results in increased expression of PTGS2 mRNA; sphingosine 1-phosphate results in increased expression of PTGS2 protein		 CTD PMID:18612546 PMID:26518876 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization		 ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate affects the localization of RELA protein modified form] CTD PMID:26518876 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 increases response to substance
multiple interactions
increases expression
affects binding		 EXP
ISO		 S1PR1 protein results in increased susceptibility to sphingosine 1-phosphate
sphingosine 1-phosphate binds to and results in increased activity of S1PR1 protein
sphingosine 1-phosphate results in increased expression of S1PR1 mRNA
S1PR1 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]
S1PR1 protein binds to sphingosine 1-phosphate		 CTD PMID:20844107 PMID:24399507 PMID:32401414 PMID:35412894 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 multiple interactions
increases activity
increases uptake
increases expression		 ISO
EXP		 S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]
[JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] results in decreased susceptibility to [sphingosine 1-phosphate co-treated with Glucose]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] which results in decreased susceptibility to sphingosine 1-phosphate; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR2 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of S1PR2 protein]
sphingosine 1-phosphate results in increased uptake of S1PR2 protein		 CTD PMID:18612546 PMID:22406263 PMID:26518876 PMID:37169277 NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574 		JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions
increases expression		 ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] CTD PMID:18612546 PMID:25980589 NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505 		JBrowse link
G S1pr5 sphingosine-1-phosphate receptor 5 multiple interactions ISO Endocannabinoids inhibits the reaction [sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein]; sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein CTD PMID:30102254 NCBI chr 8:19,786,676...19,791,862
Ensembl chr 8:19,786,663...19,791,795 		JBrowse link
G Smad3 SMAD family member 3 increases phosphorylation EXP sphingosine 1-phosphate results in increased phosphorylation of SMAD3 protein CTD PMID:37169277 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein] CTD PMID:15741222 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441 		JBrowse link
G Sphk1 sphingosine kinase 1 increases chemical synthesis
multiple interactions		 ISO SPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate
[resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA]; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein]		 CTD PMID:22251058 PMID:24399507 PMID:26045781 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Spns2 SPNS lysolipid transporter 2, sphingosine-1-phosphate increases secretion
multiple interactions		 ISO SPNS2 protein results in increased secretion of sphingosine 1-phosphate
TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate]		 CTD PMID:29772789 NCBI chr10:57,067,348...57,105,969
Ensembl chr10:57,066,897...57,105,957 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression EXP sphingosine 1-phosphate results in decreased expression of SQSTM1 protein CTD PMID:37169277 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions		 ISO sphingosine 1-phosphate results in increased phosphorylation of STAT3 protein
Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]		 CTD PMID:32401414 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate] CTD PMID:29772789 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of TNF mRNA]; sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] CTD PMID:18981156 PMID:26518876 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] CTD PMID:18981156 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        molecular messenger 18703
          signalling molecule 10566
            sphingosine 1-phosphate 55
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    main group molecular entity 19865
                      s-block molecular entity 19697
                        hydrogen molecular entity 19678
                          hydrides 19184
                            inorganic hydride 18194
                              pnictogen hydride 18184
                                nitrogen hydride 18096
                                  azane 17900
                                    ammonia 17899
                                      organic amino compound 17899
                                        amino alcohol 1076
                                          aminodiol 190
                                            2-aminooctadecene-1,3-diol 140
                                              sphingenine 140
                                                sphing-4-enine 140
                                                  sphingosine 140
                                                    sphingosine 1-phosphate 55
paths to the root