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Term:sphingosine 1-phosphate
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Accession:CHEBI:37550 term browser browse the term
Definition:A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
Synonyms:exact_synonym: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
 related_synonym: (2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid;   (2S,3R,4E)-1-(dihydrogen phosphate)2-amino-4-Octadecene-1,3-diol;   C18-Sphingosine 1-phosphate;   D-erythro-sphingosine 1-phosphate;   Formula=C18H38NO5P;   InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1;   InChIKey=DUYSYHSSBDVJSM-KRWOKUGFSA-N;   S1P;   SMILES=CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@@H](N)COP(O)(O)=O;   Sphing-4-enine 1-phosphate;   Sphingosine 1-phosphic acid
 alt_id: CHEBI:26742;   CHEBI:9225
 xref: Beilstein:5877213 "Beilstein";   CAS:26993-30-6 "ChemIDplus";   CAS:26993-30-6 "KEGG COMPOUND";   HMDB:HMDB0000277;   KEGG:C06124;   LIPID_MAPS_instance:LMSP01050001 "LIPID MAPS"
 xref_mesh: MESH:C060506
 xref: PMID:11278407 "Europe PMC";   PMID:11324700 "Europe PMC";   PMID:11331099 "Europe PMC";   PMID:11418470 "Europe PMC";   PMID:11470796 "Europe PMC";   PMID:11739995 "Europe PMC";   PMID:12039947 "Europe PMC";   PMID:12062172 "Europe PMC";   PMID:12069819 "Europe PMC";   PMID:12069830 "Europe PMC";   PMID:12401202 "Europe PMC";   PMID:12509810 "Europe PMC";   PMID:12586615 "Europe PMC";   PMID:12730100 "Europe PMC";   PMID:12742827 "Europe PMC";   PMID:12746430 "Europe PMC";   PMID:12778803 "Europe PMC";   PMID:12833634 "Europe PMC";   PMID:12963123 "Europe PMC";   PMID:12963813 "Europe PMC";   PMID:15044318 "Europe PMC";   PMID:15143482 "Europe PMC";   PMID:15158755 "Europe PMC";   PMID:15258919 "Europe PMC";   PMID:15292266 "Europe PMC";   PMID:15317688 "Europe PMC";   PMID:15326035 "Europe PMC";   PMID:15354862 "Europe PMC";   PMID:15476260 "Europe PMC";   PMID:15567060 "Europe PMC";   PMID:15696050 "Europe PMC";   PMID:15728255 "Europe PMC";   PMID:15734735 "Europe PMC";   PMID:15761190 "Europe PMC";   PMID:15778280 "Europe PMC";   PMID:15992170 "Europe PMC";   PMID:16046448 "Europe PMC";   PMID:16129068 "Europe PMC";   PMID:16162874 "Europe PMC";   PMID:16243846 "Europe PMC";   PMID:16322129 "Europe PMC";   PMID:16339142 "Europe PMC";   PMID:16434032 "Europe PMC";   PMID:16554657 "Europe PMC";   PMID:16913663 "Europe PMC";   PMID:16940153 "Europe PMC";   PMID:16956968 "Europe PMC";   PMID:17098744 "Europe PMC";   PMID:17158356 "Europe PMC";   PMID:17220911 "Europe PMC";   PMID:17308123 "Europe PMC";   PMID:17361098 "Europe PMC";   PMID:17374154 "Europe PMC";   PMID:17391120 "Europe PMC";   PMID:17409372 "Europe PMC";   PMID:17517398 "Europe PMC";   PMID:17561264 "Europe PMC";   PMID:17904858 "Europe PMC";   PMID:18155002 "Europe PMC";   PMID:18387885 "Europe PMC";   PMID:18502612 "Europe PMC";   PMID:18541717 "Europe PMC";   PMID:18787560 "Europe PMC";   PMID:18973762 "Europe PMC";   PMID:19081473 "Europe PMC";   PMID:19082500 "Europe PMC";   PMID:19268560 "Europe PMC";   PMID:19293152 "Europe PMC";   PMID:19350109 "Europe PMC";   PMID:19423865 "Europe PMC";   PMID:19556602 "Europe PMC";   PMID:19620297 "Europe PMC";   PMID:19636535 "Europe PMC";   PMID:19662499 "Europe PMC";   PMID:19808013 "Europe PMC";   PMID:19815502 "Europe PMC";   Reaxys:5877213 "Reaxys";   Wikipedia:Sphingosine-1-phosphate
 cyclic_relationship: is_conjugate_acid_of CHEBI:60119

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sphingosine 1-phosphate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Cxcr1 C-X-C motif chemokine receptor 1 JBrowse link 9 81,466,430 81,469,299 RGD:6480464
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:6480464
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:6480464
G Hrk harakiri, BCL2 interacting protein JBrowse link 12 44,008,879 44,029,211 RGD:6480464
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6480464
G Lama3 laminin subunit alpha 3 JBrowse link 18 3,704,866 3,941,215 RGD:6480464
G Lamb3 laminin subunit beta 3 JBrowse link 13 112,031,614 112,073,187 RGD:6480464
G Lamc2 laminin subunit gamma 2 JBrowse link 13 70,566,643 70,632,126 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Nrp1 neuropilin 1 JBrowse link 19 61,332,351 61,486,166 RGD:6480464
G Nrp2 neuropilin 2 JBrowse link 9 69,496,875 69,609,802 RGD:6480464
G Pecam1 platelet and endothelial cell adhesion molecule 1 JBrowse link 10 94,850,971 94,913,202 RGD:6480464
G Plcb4 phospholipase C, beta 4 JBrowse link 3 128,601,163 128,971,720 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G S1pr1 sphingosine-1-phosphate receptor 1 JBrowse link 2 218,654,406 218,658,761 RGD:6480464
G S1pr2 sphingosine-1-phosphate receptor 2 JBrowse link 8 21,984,914 21,995,806 RGD:6480464
G S1pr3 sphingosine-1-phosphate receptor 3 JBrowse link 17 13,799,383 13,812,877 RGD:6480464
G Smpd2 sphingomyelin phosphodiesterase 2 JBrowse link 20 46,212,070 46,215,183 RGD:6480464
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:6480464
G Spns2 sphingolipid transporter 2 JBrowse link 10 59,010,428 59,049,482 RGD:6480464
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      biological role 19596
        molecular messenger 17921
          signalling molecule 8070
            sphingosine 1-phosphate 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    main group molecular entity 19531
                      s-block molecular entity 19314
                        hydrogen molecular entity 19303
                          hydrides 18231
                            inorganic hydride 17095
                              pnictogen hydride 17053
                                nitrogen hydride 16874
                                  azane 16551
                                    ammonia 16548
                                      organic amino compound 16547
                                        amino alcohol 862
                                          aminodiol 151
                                            2-aminooctadecene-1,3-diol 111
                                              sphingenine 111
                                                sphing-4-enine 111
                                                  sphingosine 111
                                                    sphingosine 1-phosphate 38
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.