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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:clofazimine
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Accession:CHEBI:3749 term browser browse the term
Definition:3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Synonyms:exact_synonym: N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine
 related_synonym: (4-Chloro-phenyl)-[5-(4-chloro-phenyl)-3-isopropylimino-3,5-dihydro-phenazin-2-yl]-amine;   3-(p-chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine;   3-(p-chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin;   Formula=C27H22Cl2N4;   InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3;   InChIKey=WDQPAMHFFCXSNU-UHFFFAOYSA-N;   N,5-bis(4-chlorophenyl)-3-(isopropylimino)-3,5-dihydrophenazin-2-amine;   SMILES=CC(C)N=c1cc2n(-c3ccc(Cl)cc3)c3ccccc3nc2cc1Nc1ccc(Cl)cc1;   clofazimina;   clofaziminum
 alt_id: CHEBI:355347
 xref: Beilstein:8168151;   CAS:2030-63-9;   DrugBank:DB00845;   KEGG:C06915;   KEGG:D00278;   LINCS:LSM-5669
 xref_mesh: MESH:D002991
 xref: PMID:17210775;   PMID:3279207;   Patent:US2948726


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clofazimine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Clofazimine results in decreased activity of ABCB11 protein CTD PMID:20829430, PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression EXP Clofazimine results in increased expression of ACACA mRNA CTD PMID:31393584 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression EXP Clofazimine results in increased expression of CEBPA protein CTD PMID:31393584 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 decreases expression EXP Clofazimine results in decreased expression of DGAT1 mRNA CTD PMID:31393584 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP Clofazimine results in increased expression of FAS mRNA CTD PMID:31393584 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Clofazimine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Clofazimine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP Clofazimine results in increased expression of PPARG mRNA; Clofazimine results in increased expression of PPARG protein CTD PMID:31393584 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP Clofazimine results in increased expression of SREBF1 mRNA CTD PMID:31393584 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Zfp423 zinc finger protein 423 increases expression EXP Clofazimine results in increased expression of ZFP423 mRNA CTD PMID:31393584 NCBI chr19:20,147,201...20,405,999
Ensembl chr19:20,147,037...20,406,003
JBrowse link

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  CHEBI ontology 19816
    role 19764
      application 19426
        dye 1299
          clofazimine 10
Path 2
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  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                carbocyclic compound 18222
                                  benzenoid aromatic compound 17254
                                    benzenes 17010
                                      chlorobenzenes 13342
                                        monochlorobenzenes 9524
                                          clofazimine 10
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