dihydroxyanthraquinone - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	dihydroxyanthraquinone	go back to main search page
Accession:	CHEBI:37484	browse the term
Synonyms:	exact_synonym:	dihydroxyanthracene-9,10-dione
	related_synonym:	Formula=C14H8O4; dihydroxy-9,10-anthracenedione; dihydroxy-9,10-anthraquinone
	xref:	CAS:1322-60-7

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Rat (350) Mouse (354) Human (370) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (370)

2-hydroxychrysophanol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 1 subfamily A member 2

multiple interactions
increases chemical synthesis

[CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol
CYP1A2 protein results in increased chemical synthesis of 2-hydroxychrysophanol

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 3 subfamily A member 4

increases chemical synthesis
multiple interactions

CYP3A4 protein results in increased chemical synthesis of 2-hydroxychrysophanol
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

affects binding

Alizarin Red S binds to ALB protein

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

alizarin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 1 subfamily A member 1

decreases activity
multiple interactions

alizarin results in decreased activity of CYP1A1 protein
alizarin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein]

PMID:12379470 PMID:37515497

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

alizarin results in decreased activity of CYP1A2 protein

PMID:12379470 PMID:33438235

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 1 subfamily B member 1

decreases activity

alizarin results in decreased activity of CYP1B1 protein

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 2 subfamily A member 6

decreases activity

alizarin results in decreased activity of CYP2A6 protein

NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447

G

cytochrome P450 family 2 subfamily C member 9

decreases activity

alizarin results in decreased activity of CYP2C9 protein

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 2 subfamily E member 1

decreases activity

alizarin results in decreased activity of CYP2E1 protein

NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220

G

estrogen receptor 1

multiple interactions

alizarin binds to and results in increased activity of ESR1 protein

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

H2A.X variant histone

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

mitogen-activated protein kinase 1

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]; alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC protein]

NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138

G

N-acetyltransferase 1

decreases activity

alizarin results in decreased activity of NAT1 protein

NCBI chr 8:18,170,467...18,223,689
Ensembl chr 8:18,170,477...18,223,689

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of alizarin

NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300

G

UDP glucuronosyltransferase family 1 member A10

increases glucuronidation

UGT1A10 protein results in increased glucuronidation of alizarin

NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300

G

UDP glucuronosyltransferase family 1 member A7

increases glucuronidation

UGT1A7 protein results in increased glucuronidation of alizarin

NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300

G

UDP glucuronosyltransferase family 1 member A8

increases glucuronidation

UGT1A8 protein results in increased glucuronidation of alizarin

NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of alizarin

NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of alizarin

NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652

Aloe emodin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in decreased expression of ADIPOQ mRNA]

NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463

G

aldo-keto reductase family 1 member B10

decreases activity

aloe emodin results in decreased activity of AKR1B10 protein

NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412

G

aldo-keto reductase family 1 member C3

decreases activity

aloe emodin results in decreased activity of AKR1C3 protein

NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686

G

activating transcription factor 3

increases expression

aloe emodin results in increased expression of ATF3 mRNA

NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777

G

BCL2 associated X, apoptosis regulator

increases expression

aloe emodin results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression

aloe emodin results in decreased expression of BCL2 mRNA; aloe emodin results in decreased expression of BCL2 protein

PMID:19928967 PMID:22210228

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

caspase 3

increases activity
multiple interactions
increases cleavage
increases expression

aloe emodin results in increased activity of CASP3 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP3; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP3 protein modified form]
aloe emodin results in increased cleavage of CASP3 protein

PMID:19928967 PMID:22210228

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

increases activity
multiple interactions
increases expression

aloe emodin results in increased activity of CASP8 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP8; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP8 protein modified form]

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

increases activity
increases expression
multiple interactions

aloe emodin results in increased activity of CASP9 protein
aloe emodin results in increased expression of CASP9 protein modified form
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP9; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP9 protein modified form]

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

carbonyl reductase 1

decreases activity

aloe emodin results in decreased activity of CBR1 protein

NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166

G

cytochrome c, somatic

increases expression

aloe emodin results in increased expression of CYCS protein

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

cytochrome P450 family 1 subfamily A member 1

decreases activity

aloe emodin results in decreased activity of CYP1A1 protein

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

aloe emodin results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:33438235

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 1 subfamily B member 1

decreases activity

aloe emodin results in decreased activity of CYP1B1 protein

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 2 subfamily B member 6

multiple interactions
increases chemical synthesis

[CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CYP2B6 protein results in increased chemical synthesis of aloe emodin

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

G

cytochrome P450 family 2 subfamily C member 19

decreases activity

aloe emodin results in decreased activity of CYP2C19 protein

NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547

G

cytochrome P450 family 2 subfamily C member 9

decreases activity

aloe emodin results in decreased activity of CYP2C9 protein

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 3 subfamily A member 4

multiple interactions
increases chemical synthesis

[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CYP3A4 protein results in increased chemical synthesis of aloe emodin

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

DNA damage inducible transcript 3

increases expression

aloe emodin results in increased expression of DDIT3 mRNA; aloe emodin results in increased expression of DDIT3 protein

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

aloe emodin results in increased phosphorylation of EIF2S1 protein

NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516

G

fatty acid binding protein 4

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of FABP4 mRNA]

NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236

G

Fas associated via death domain

multiple interactions

aloe emodin results in increased expression of and affects the localization of FADD protein

NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390

G

Fas cell surface death receptor

increases expression

aloe emodin results in increased expression of FAS protein

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fas ligand

increases expression

aloe emodin results in increased expression of FASLG protein

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

heat shock protein family A (Hsp70) member 5

increases expression

aloe emodin results in increased expression of HSPA5 mRNA; aloe emodin results in increased expression of HSPA5 protein

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

lipoprotein lipase

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of LPL mRNA]

NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259

G

N-acetyltransferase 1

multiple interactions
decreases expression

aloe emodin results in decreased expression of and results in decreased activity of NAT1 protein
aloe emodin results in decreased expression of NAT1 mRNA

NCBI chr 8:18,170,467...18,223,689
Ensembl chr 8:18,170,477...18,223,689

G

nitric oxide synthase 2

multiple interactions

aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

peroxisome proliferator activated receptor gamma

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of PPARG mRNA]

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

prostaglandin-endoperoxide synthase 2

multiple interactions

aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

resistin

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of RETN mRNA]

NCBI chr19:7,669,049...7,670,455
Ensembl chr19:7,669,049...7,670,455

G

sulfotransferase family 1A member 1

decreases activity

aloe emodin results in decreased activity of SULT1A1 protein

NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044

G

sulfotransferase family 1E member 1

decreases activity

aloe emodin results in decreased activity of SULT1E1 protein

NCBI chr 4:69,821,122...69,860,145
Ensembl chr 4:69,841,212...69,860,145

G

tumor necrosis factor

multiple interactions
increases expression

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of TNF mRNA]
aloe emodin results in increased expression of TNF protein

PMID:19928967 PMID:22645054

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF receptor superfamily member 1A

increases expression

aloe emodin results in increased expression of TNFRSF1A protein

NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114

G

TNF receptor superfamily member 1B

increases expression

aloe emodin results in increased expression of TNFRSF1B protein

NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228

G

tumor protein p53

increases expression

aloe emodin results in increased expression of TP53 protein

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

TNFRSF1A associated via death domain

multiple interactions

aloe emodin results in increased expression of and affects the localization of TRADD protein

NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of aloe emodin

NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300

G

X-box binding protein 1

increases splicing

aloe emodin results in increased splicing of XBP1 mRNA

NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597

anthraflavic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

2,6-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

albumin

affects binding

2,6-dihydroxyanthraquinone binds to ALB protein

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

cytochrome P450 family 1 subfamily A member 1

increases expression

2,6-dihydroxyanthraquinone results in increased expression of CYP1A1 mRNA

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily B member 1

increases expression

2,6-dihydroxyanthraquinone results in increased expression of CYP1B1 mRNA

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

PMID:12756209 PMID:14557274

NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300

G

UDP glucuronosyltransferase family 1 member A10

increases glucuronidation

UGT1A10 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300

G

UDP glucuronosyltransferase family 1 member A7

increases glucuronidation

UGT1A7 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300

G

UDP glucuronosyltransferase family 1 member A8

increases glucuronidation

UGT1A8 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of 2,6-dihydroxyanthraquinone

NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652

chrysazin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

danthron inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

apoptosis inducing factor mitochondria associated 1

increases expression
multiple interactions

danthron results in increased expression of AIFM1 mRNA
danthron affects the localization of and results in increased expression of AIFM1 protein

NCBI chr X:130,129,362...130,165,841
Ensembl chr X:130,124,666...130,165,879

G

albumin

affects binding

danthron binds to ALB protein

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

activating transcription factor 6

increases expression

danthron results in increased expression of ATF6 protein

NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574

G

BCL2 associated X, apoptosis regulator

increases expression

danthron results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression

danthron results in decreased expression of BCL2 protein

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

increases expression
decreases expression

danthron results in increased expression of BCL2L1 protein
danthron results in decreased expression of BCL2L1 protein

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

BH3 interacting domain death agonist

increases expression

danthron results in increased expression of BID protein

NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770

G

baculoviral IAP repeat containing 2

decreases expression

danthron results in decreased expression of BIRC2 protein

NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670

G

baculoviral IAP repeat containing 3

increases expression

danthron results in increased expression of BIRC3 protein

NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403

G

baculoviral IAP repeat containing 5

decreases expression

danthron results in decreased expression of BIRC5 protein

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

caspase 3

multiple interactions
increases expression

benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP3 protein]; danthron results in increased activity of and results in increased expression of CASP3 protein
danthron results in increased expression of CASP3 mRNA

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

multiple interactions
increases expression

benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP8 protein]; danthron results in increased activity of and results in increased expression of CASP8 protein
danthron results in increased expression of CASP8 mRNA

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

multiple interactions
increases expression

benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP9 protein]; danthron results in increased activity of and results in increased expression of CASP9 protein
danthron results in increased expression of CASP9 mRNA

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

cytochrome c, somatic

multiple interactions

danthron affects the localization of and results in increased expression of CYCS protein

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

danthron results in decreased activity of CYP1A2 protein

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

DNA damage inducible transcript 3

increases expression

danthron results in increased expression of DDIT3 protein

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

diablo IAP-binding mitochondrial protein

increases expression

danthron results in increased expression of DIABLO protein

NCBI chr12:122,207,662...122,227,456
Ensembl chr12:122,207,668...122,226,062

G

endonuclease G

increases expression
multiple interactions

danthron results in increased expression of ENDOG mRNA
danthron affects the localization of and results in increased expression of ENDOG protein

NCBI chr 9:128,818,500...128,822,676
Ensembl chr 9:128,818,500...128,822,676

G

Fas cell surface death receptor

increases expression

danthron results in increased expression of FAS protein

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fas ligand

increases expression

danthron results in increased expression of FASLG protein

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

heat shock protein family A (Hsp70) member 5

increases expression

danthron results in increased expression of HSPA5 protein

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

superoxide dismutase 1

decreases expression

danthron results in decreased expression of SOD1 protein

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

superoxide dismutase 2

decreases expression

danthron results in decreased expression of SOD2 protein

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

TNF superfamily member 10

increases expression

danthron results in increased expression of TNFSF10 protein

NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475

G

X-linked inhibitor of apoptosis

decreases expression

danthron results in decreased expression of XIAP protein

NCBI chr X:123,859,708...123,913,972
Ensembl chr X:123,859,712...123,913,972

chrysophanol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases expression

chrysophanic acid results in decreased expression of ABCB11 mRNA; chrysophanic acid results in decreased expression of ABCB11 protein

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ATP binding cassette subfamily C member 2

increases expression

chrysophanic acid results in increased expression of ABCC2 mRNA; chrysophanic acid results in increased expression of ABCC2 protein

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ATP binding cassette subfamily C member 4 (PEL blood group)

increases expression

chrysophanic acid results in increased expression of ABCC4 mRNA; chrysophanic acid results in increased expression of ABCC4 protein

NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475

G

aryl hydrocarbon receptor

multiple interactions

chrysophanic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

AKT serine/threonine kinase 1

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of AKT1 protein

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

BCL2 antagonist/killer 1

increases expression

chrysophanic acid results in increased expression of BAK1 protein

NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293

G

BCL2 associated X, apoptosis regulator

increases expression

chrysophanic acid results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

cytochrome P450 family 1 subfamily A member 1

decreases activity

chrysophanic acid results in decreased activity of CYP1A1 protein

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

decreases activity
increases metabolic processing
multiple interactions

chrysophanic acid results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased metabolism of chrysophanic acid
[CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol

PMID:27633141 PMID:29698620 PMID:33438235

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 1 subfamily B member 1

decreases activity

chrysophanic acid results in decreased activity of CYP1B1 protein

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 2 subfamily B member 6

multiple interactions
increases metabolic processing

[CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

G

cytochrome P450 family 2 subfamily C member 9

decreases activity

chrysophanic acid results in decreased activity of CYP2C9 protein

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 3 subfamily A member 4

increases metabolic processing
multiple interactions
increases chemical synthesis

CYP3A4 protein results in increased metabolism of chrysophanic acid
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol; [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CYP3A4 protein results in increased chemical synthesis of chrysophanic acid metabolite

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

cytochrome P450 family 7 subfamily A member 1

increases expression

chrysophanic acid results in increased expression of CYP7A1 mRNA; chrysophanic acid results in increased expression of CYP7A1 protein

NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

chrysophanic acid results in decreased expression of CYP8B1 mRNA; chrysophanic acid results in decreased expression of CYP8B1 protein

NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898

G

DNA damage inducible transcript 3

increases expression

chrysophanic acid results in increased expression of DDIT3 protein

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation
multiple interactions

chrysophanic acid results in increased phosphorylation of EIF2S1 protein
Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2S1 protein]

NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516

G

endoplasmic reticulum to nucleus signaling 1

increases expression

chrysophanic acid results in increased expression of ERN1 protein

NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819

G

mitogen-activated protein kinase 1

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of MAPK1 protein

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 14

affects phosphorylation

chrysophanic acid affects the phosphorylation of MAPK14 protein

NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236

G

mitogen-activated protein kinase 3

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of MAPK3 protein

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

affects phosphorylation

chrysophanic acid affects the phosphorylation of MAPK8 protein

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

proliferating cell nuclear antigen

decreases expression

chrysophanic acid results in decreased expression of PCNA protein

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

G

ribosomal protein S6

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of RPS6 protein

NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236

G

ribosomal protein S6 kinase B1

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of RPS6KB1 protein

NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574

G

solute carrier family 10 member 1

decreases expression

chrysophanic acid results in decreased expression of SLC10A1 mRNA; chrysophanic acid results in decreased expression of SLC10A1 protein

NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241

G

solute carrier family 22 member 6

decreases activity

chrysophanic acid results in decreased activity of SLC22A6 protein

NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967

G

solute carrier family 22 member 8

decreases activity

chrysophanic acid results in decreased activity of SLC22A8 protein

NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841

G

sulfotransferase family 1A member 1

decreases activity

chrysophanic acid results in decreased activity of SULT1A1 protein

NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of chrysophanic acid

NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300

mitoxantrone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

affects response to substance

ABCA1 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155

G

ATP binding cassette subfamily B member 1

increases expression

Mitoxantrone results in increased expression of ABCB1 protein

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily G member 2 (JR blood group)

affects export
affects response to substance
increases export
increases transport
multiple interactions
decreases response to substance
increases expression
decreases abundance
affects uptake
affects transport
increases response to substance

ABCG2 protein affects the export of Mitoxantrone
ABCG2 protein affects the susceptibility to Mitoxantrone
ABCG2 protein results in increased export of Mitoxantrone
ABCG2 protein results in increased transport of Mitoxantrone
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] inhibits the reaction [Folic Acid deficiency results in decreased susceptibility to Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; [5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; [Folic Acid deficiency results in increased expression of ABCG2 protein] which results in decreased susceptibility to Mitoxantrone; [Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [MLN 8237 affects the activity of ABCG2 protein] which affects the export of Mitoxantrone; ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone; Beclomethasone inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Cadmium Chloride inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Dactinomycin inhibits the reaction [Mitoxantrone results in increased expression of ABCG2 mRNA]; desisobutyrylciclesonide inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 gene mutant form results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Haloperidol inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Novobiocin inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Olanzapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; oxfendazole inhibits the reaction [ABCG2 protein affects the transport of Mitoxantrone]; Paliperidone Palmitate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Protons promotes the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Quetiapine Fumarate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Risperidone inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein affects the uptake of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mitoxantrone results in increased expression of ABCG2 mRNA; Mitoxantrone results in increased expression of ABCG2 protein
ABCG2 protein results in decreased abundance of Mitoxantrone
ABCG2 protein results in increased susceptibility to Mitoxantrone

PMID:10606239 PMID:12869632 PMID:15239124 PMID:15640379 PMID:15695404 More...

NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628

G

acyl-CoA dehydrogenase very long chain

decreases expression

Mitoxantrone results in decreased expression of ACADVL protein

NCBI chr17:7,217,125...7,225,266
Ensembl chr17:7,217,125...7,225,266

G

acyl-CoA synthetase long chain family member 3

affects response to substance

ACSL3 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:222,861,036...222,944,639
Ensembl chr 2:222,860,942...222,944,639

G

actin alpha 1, skeletal muscle

decreases expression

Mitoxantrone results in decreased expression of ACTA1 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:229,431,245...229,434,094
Ensembl chr 1:229,430,365...229,434,104

G

actin gamma 2, smooth muscle

affects response to substance

ACTG2 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:73,893,008...73,919,865
Ensembl chr 2:73,892,314...73,919,865

G

adenosine deaminase RNA specific B1

affects response to substance

ADARB1 protein affects the susceptibility to Mitoxantrone

NCBI chr21:45,074,578...45,226,563
Ensembl chr21:45,073,853...45,226,560

G

1-acylglycerol-3-phosphate O-acyltransferase 5

affects response to substance

AGPAT5 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:6,708,642...6,761,503
Ensembl chr 8:6,708,642...6,761,503

G

adenosylhomocysteinase like 1

affects response to substance

AHCYL1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:109,984,765...110,023,742
Ensembl chr 1:109,984,765...110,023,742

G

aldehyde dehydrogenase 2 family member

affects response to substance

ALDH2 protein affects the susceptibility to Mitoxantrone

NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532

G

angiomotin like 1

affects response to substance

AMOTL1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr11:94,706,460...94,876,748
Ensembl chr11:94,706,431...94,876,748

G

ankyrin 2

decreases expression

Mitoxantrone results in decreased expression of ANK2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 4:112,705,622...113,383,736
Ensembl chr 4:112,818,032...113,384,221

G

apolipoprotein B mRNA editing enzyme catalytic subunit 3C

affects response to substance

APOBEC3C protein affects the susceptibility to Mitoxantrone

NCBI chr22:39,014,257...39,020,352
Ensembl chr22:39,014,257...39,020,352

G

asparagine synthetase (glutamine-hydrolyzing)

affects response to substance

ASNS protein affects the susceptibility to Mitoxantrone

NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542

G

argininosuccinate synthase 1

affects response to substance

ASS1 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:130,444,707...130,501,274
Ensembl chr 9:130,444,961...130,501,274

G

autophagy related 5

decreases expression

Mitoxantrone results in decreased expression of ATG5 protein

NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791

G

ATM serine/threonine kinase

decreases expression
increases phosphorylation
multiple interactions

Mitoxantrone results in decreased expression of ATM mRNA
Mitoxantrone results in increased phosphorylation of ATM protein
[Poly(ADP-ribose) Polymerase Inhibitors co-treated with Mitoxantrone] results in increased phosphorylation of ATM protein

PMID:22832221 PMID:29913208

NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102

G

ATPase Na+/K+ transporting subunit alpha 2

decreases expression

Mitoxantrone results in decreased expression of ATP1A2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591

G

ATP synthase F1 subunit alpha

decreases expression

Mitoxantrone results in decreased expression of ATP5F1A protein

NCBI chr18:46,080,248...46,104,227
Ensembl chr18:46,080,248...46,104,334

G

ATP synthase F1 subunit beta

decreases expression

Mitoxantrone results in decreased expression of ATP5F1B protein

NCBI chr12:56,638,175...56,645,984
Ensembl chr12:56,638,175...56,645,984

G

ATP synthase F1 subunit gamma

decreases expression

Mitoxantrone results in decreased expression of ATP5F1C protein

NCBI chr10:7,788,177...7,807,801
Ensembl chr10:7,788,147...7,807,815

G

ATPase copper transporting alpha

decreases response to substance

ATP7A protein results in decreased susceptibility to Mitoxantrone

NCBI chr X:77,910,693...78,050,395
Ensembl chr X:77,910,690...78,050,395

G

beta-secretase 2

affects response to substance

BACE2 protein affects the susceptibility to Mitoxantrone

NCBI chr21:41,168,160...41,282,530
Ensembl chr21:41,167,801...41,282,530

G

BCL2 associated X, apoptosis regulator

increases expression

Mitoxantrone results in increased expression of BAX mRNA

PMID:26537877 PMID:28940058

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BBX high mobility group box domain containing

affects response to substance

BBX protein affects the susceptibility to Mitoxantrone

NCBI chr 3:107,522,962...107,811,339
Ensembl chr 3:107,522,936...107,811,339

G

basal cell adhesion molecule (Lutheran blood group)

affects response to substance

BCAM protein affects the susceptibility to Mitoxantrone

NCBI chr19:44,809,059...44,821,421
Ensembl chr19:44,809,071...44,821,421

G

branched chain amino acid transaminase 1

increases expression

Mitoxantrone results in increased expression of BCAT1 mRNA

NCBI chr12:24,810,024...24,949,340
Ensembl chr12:24,810,024...24,949,101

G

BCL2 apoptosis regulator

multiple interactions
decreases expression

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]
Mitoxantrone results in decreased expression of BCL2 mRNA

PMID:8219202 PMID:8840993 PMID:15582267

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

multiple interactions

BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

beclin 1

decreases expression

Mitoxantrone results in decreased expression of BECN1 protein

NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350

G

baculoviral IAP repeat containing 2

decreases expression

Mitoxantrone results in decreased expression of BIRC2 protein

NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670

G

baculoviral IAP repeat containing 5

affects expression
increases expression

Mitoxantrone affects the expression of BIRC5 mRNA
Mitoxantrone results in increased expression of BIRC5 protein

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

bone morphogenetic protein 7

affects response to substance

BMP7 protein affects the susceptibility to Mitoxantrone

NCBI chr20:57,168,753...57,266,641
Ensembl chr20:57,168,753...57,266,641

G

bone marrow stromal cell antigen 2

affects response to substance

BST2 protein affects the susceptibility to Mitoxantrone

NCBI chr19:17,402,939...17,405,630
Ensembl chr19:17,402,939...17,405,630

G

BTB domain containing 3

affects response to substance

BTBD3 protein affects the susceptibility to Mitoxantrone

NCBI chr20:11,890,817...11,926,595
Ensembl chr20:11,890,723...11,926,609

G

calcium voltage-gated channel subunit alpha1 G

decreases expression

Mitoxantrone results in decreased expression of CACNA1G mRNA

PMID:26537877 PMID:28940058

NCBI chr17:50,560,715...50,627,474
Ensembl chr17:50,560,715...50,627,474

G

calcium voltage-gated channel auxiliary subunit alpha2delta 2

decreases expression

Mitoxantrone results in decreased expression of CACNA2D2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 3:50,362,613...50,504,244
Ensembl chr 3:50,362,613...50,504,244

G

calreticulin

affects localization

Mitoxantrone affects the localization of CALR protein

NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489

G

calcium/calmodulin dependent protein kinase II inhibitor 1

affects response to substance

CAMK2N1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:20,482,391...20,486,210
Ensembl chr 1:20,482,391...20,486,210

G

CASC3 exon junction complex subunit

affects response to substance

CASC3 mRNA affects the susceptibility to Mitoxantrone

NCBI chr17:40,140,537...40,172,171
Ensembl chr17:40,140,318...40,172,171

G

caspase 2

increases expression
increases splicing

Mitoxantrone results in increased expression of CASP2 mRNA alternative form
Mitoxantrone results in increased splicing of CASP2 mRNA

NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696

G

caspase 3

multiple interactions
increases activity

BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP3 protein]
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]

PMID:8840993 PMID:12948851 PMID:16215684 PMID:22700542 PMID:32894303

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 6

increases activity

Mitoxantrone results in increased activity of CASP6 protein

NCBI chr 4:109,664,388...109,709,767
Ensembl chr 4:109,688,622...109,703,583

G

caspase 7

increases activity
multiple interactions

Mitoxantrone results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP7 protein]

PMID:12948851 PMID:22700542

NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907

G

caspase 8

increases activity

Mitoxantrone results in increased activity of CASP8 protein

PMID:12948851 PMID:32894303

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

increases activity

Mitoxantrone results in increased activity of CASP9 protein

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

catalase

decreases activity

Mitoxantrone results in decreased activity of CAT protein

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

caveolae associated protein 3

affects response to substance

CAVIN3 protein affects the susceptibility to Mitoxantrone

NCBI chr11:6,318,946...6,320,501
Ensembl chr11:6,318,946...6,320,532

G

caveolae associated protein 4

decreases expression

Mitoxantrone results in decreased expression of CAVIN4 mRNA

PMID:26537877 PMID:28940058

NCBI chr 9:100,576,867...100,588,389
Ensembl chr 9:100,578,079...100,588,389

G

CD55 molecule (Cromer blood group)

affects response to substance

CD55 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:207,321,678...207,360,966
Ensembl chr 1:207,321,519...207,386,804

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CD58 molecule

affects response to substance

CD58 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:116,514,534...116,571,026
Ensembl chr 1:116,514,534...116,571,039

G

CUGBP Elav-like family member 2

affects response to substance

CELF2 protein affects the susceptibility to Mitoxantrone

NCBI chr10:10,462,550...11,336,675
Ensembl chr10:10,798,397...11,336,675

G

centrosomal protein 15

affects response to substance

CEP15 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:62,319,022...62,336,213
Ensembl chr 3:62,319,015...62,336,213

G

carboxylesterase 2

affects response to substance

CES2 protein affects the susceptibility to Mitoxantrone

NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096

G

chordin like 1

affects response to substance

CHRDL1 protein affects the susceptibility to Mitoxantrone

NCBI chr X:110,673,856...110,795,817
Ensembl chr X:110,673,856...110,795,819

G

chemokine like factor

affects response to substance

CKLF protein affects the susceptibility to Mitoxantrone

NCBI chr16:66,552,563...66,566,287
Ensembl chr16:66,552,563...66,566,251

G

creatine kinase, M-type

decreases expression

Mitoxantrone results in decreased expression of CKM mRNA

PMID:26537877 PMID:28940058

NCBI chr19:45,306,413...45,322,875
Ensembl chr19:45,306,413...45,322,875

G

chloride nucleotide-sensitive channel 1A

affects response to substance

CLNS1A protein affects the susceptibility to Mitoxantrone

NCBI chr11:77,614,530...77,637,794
Ensembl chr11:77,514,936...77,637,794

G

clusterin

affects response to substance

CLU protein affects the susceptibility to Mitoxantrone

NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700

G

cochlin

affects response to substance

COCH protein affects the susceptibility to Mitoxantrone

NCBI chr14:30,874,559...30,895,615
Ensembl chr14:30,874,514...30,895,065

G

collagen type XI alpha 1 chain

affects response to substance

COL11A1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:102,876,473...103,108,522
Ensembl chr 1:102,876,467...103,108,872

G

corin, serine peptidase

decreases expression

Mitoxantrone results in decreased expression of CORIN mRNA

PMID:26537877 PMID:28940058

NCBI chr 4:47,594,001...47,838,067
Ensembl chr 4:47,593,999...47,838,106

G

carboxypeptidase vitellogenic like

affects response to substance

CPVL protein affects the susceptibility to Mitoxantrone

NCBI chr 7:28,994,636...29,195,451
Ensembl chr 7:28,995,235...29,195,451

G

cAMP responsive element binding protein like 2

affects response to substance

CREBL2 protein affects the susceptibility to Mitoxantrone

NCBI chr12:12,611,876...12,645,108
Ensembl chr12:12,611,827...12,645,108

G

citrate synthase

decreases activity

Mitoxantrone results in decreased activity of CS protein

NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391

G

cysteine and serine rich nuclear protein 2

affects response to substance

CSRNP2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr12:51,061,205...51,083,596
Ensembl chr12:51,061,205...51,083,664

G

cystathionine gamma-lyase

affects response to substance

CTH protein affects the susceptibility to Mitoxantrone

NCBI chr 1:70,411,268...70,439,851
Ensembl chr 1:70,411,218...70,439,851

G

CXADR Ig-like cell adhesion molecule

affects response to substance

CXADR protein affects the susceptibility to Mitoxantrone

NCBI chr21:17,513,043...17,636,262
Ensembl chr21:17,513,043...17,593,579

G

cytochrome P450 family 1 subfamily A member 1

decreases activity

Mitoxantrone results in decreased activity of CYP1A1 protein

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily B member 1

decreases activity

Mitoxantrone results in decreased activity of CYP1B1 protein

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

death associated protein kinase 1

affects response to substance

DAPK1 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:87,497,228...87,708,634
Ensembl chr 9:87,497,228...87,708,634

G

DNA damage inducible transcript 4

affects response to substance

DDIT4 protein affects the susceptibility to Mitoxantrone

NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036

G

dehydrogenase/reductase 2

affects response to substance

DHRS2 protein affects the susceptibility to Mitoxantrone

NCBI chr14:23,630,115...23,645,639
Ensembl chr14:23,630,115...23,645,639

G

DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease

affects response to substance

DIS3 protein affects the susceptibility to Mitoxantrone

NCBI chr13:72,752,169...72,781,900
Ensembl chr13:72,752,169...72,782,096

G

dystrophin

decreases expression

Mitoxantrone results in decreased expression of DMD mRNA

PMID:26537877 PMID:28940058

NCBI chr X:31,119,222...33,339,388
Ensembl chr X:31,097,677...33,339,609

G

dual specificity phosphatase 4

affects response to substance
increases expression

DUSP4 protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in increased expression of DUSP4 mRNA

PMID:16217747 PMID:26537877 PMID:28940058

NCBI chr 8:29,333,064...29,350,684
Ensembl chr 8:29,333,064...29,350,684

G

dual specificity tyrosine phosphorylation regulated kinase 2

affects response to substance

DYRK2 protein affects the susceptibility to Mitoxantrone

NCBI chr12:67,648,745...67,665,406
Ensembl chr12:67,648,338...67,665,406

G

early growth response 1

affects response to substance

EGR1 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

G

eukaryotic translation initiation factor 2 subunit alpha

affects response to substance

EIF2S1 protein affects the susceptibility to Mitoxantrone

NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516

G

eukaryotic translation initiation factor 5A

affects response to substance

EIF5A protein affects the susceptibility to Mitoxantrone

NCBI chr17:7,306,999...7,312,463
Ensembl chr17:7,306,999...7,312,463

G

ELAV like RNA binding protein 4

affects response to substance

ELAVL4 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 1:50,048,055...50,203,772
Ensembl chr 1:50,024,029...50,203,772

G

ELOVL fatty acid elongase 5

affects response to substance

ELOVL5 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 6:53,267,404...53,348,950
Ensembl chr 6:53,267,398...53,349,179

G

engrailed homeobox 2

affects response to substance

EN2 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:155,458,129...155,464,831
Ensembl chr 7:155,458,129...155,464,831

G

ectodermal-neural cortex 1

affects response to substance

ENC1 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:74,627,409...74,640,728
Ensembl chr 5:74,627,406...74,641,424

G

erythrocyte membrane protein band 4.1 like 2

affects response to substance

EPB41L2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 6:130,839,347...131,063,245
Ensembl chr 6:130,839,347...131,063,322

G

erb-b2 receptor tyrosine kinase 2

multiple interactions
decreases response to substance

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]

NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426

G

erb-b2 receptor tyrosine kinase 3

decreases expression

Mitoxantrone results in decreased expression of ERBB3 mRNA

PMID:26537877 PMID:28940058

NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505

G

electron transfer flavoprotein dehydrogenase

decreases expression

Mitoxantrone results in decreased expression of ETFDH protein

NCBI chr 4:158,672,296...158,709,623
Ensembl chr 4:158,671,968...158,710,742

G

ecotropic viral integration site 5

affects response to substance

EVI5 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:92,508,696...92,792,410
Ensembl chr 1:92,508,696...92,792,404

G

exostosin like glycosyltransferase 2

affects response to substance

EXTL2 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:100,872,372...100,895,179
Ensembl chr 1:100,872,372...100,895,179

G

fatty acid binding protein 3

increases expression

Mitoxantrone results in increased expression of FABP3 protein

NCBI chr 1:31,359,588...31,373,076
Ensembl chr 1:31,365,253...31,376,850

G

family with sequence similarity 117 member A

affects response to substance

FAM117A protein affects the susceptibility to Mitoxantrone

NCBI chr17:49,710,332...49,789,110
Ensembl chr17:49,710,332...49,789,180

G

Fas cell surface death receptor

multiple interactions
increases expression

Hydrocortisone promotes the reaction [Mitoxantrone results in increased expression of FAS]
Mitoxantrone results in increased expression of FAS mRNA; Mitoxantrone results in increased expression of FAS protein

PMID:9676859 PMID:26537877 PMID:28940058

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

fatty acid synthase

decreases response to substance
multiple interactions

FASN protein results in decreased susceptibility to Mitoxantrone
orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]

NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294

G

farnesyl-diphosphate farnesyltransferase 1

affects response to substance

FDFT1 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:11,795,582...11,839,309
Ensembl chr 8:11,795,573...11,839,395

G

four and a half LIM domains 1

increases expression

Mitoxantrone results in increased expression of FHL1 mRNA

NCBI chr X:136,146,702...136,211,359
Ensembl chr X:136,146,702...136,211,359

G

fibronectin leucine rich transmembrane protein 3

affects response to substance

FLRT3 protein affects the susceptibility to Mitoxantrone

NCBI chr20:14,322,985...14,337,612
Ensembl chr20:14,322,985...14,337,614

G

fibronectin type III domain containing 3A

affects response to substance

FNDC3A protein affects the susceptibility to Mitoxantrone

NCBI chr13:48,975,291...49,209,779
Ensembl chr13:48,975,912...49,209,779

G

forkhead box F2

affects response to substance

FOXF2 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:1,389,576...1,395,603
Ensembl chr 6:1,389,576...1,395,603

G

FYN proto-oncogene, Src family tyrosine kinase

affects response to substance

FYN protein affects the susceptibility to Mitoxantrone

NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452

G

frizzled class receptor 2

affects response to substance

FZD2 protein affects the susceptibility to Mitoxantrone

NCBI chr17:44,557,484...44,561,262
Ensembl chr17:44,557,484...44,561,262

G

G antigen 2A

affects response to substance

GAGE2A protein affects the susceptibility to Mitoxantrone

NCBI chr X:49,589,496...49,596,824
Ensembl chr X:49,589,496...49,596,824

G

G antigen 4

affects response to substance

GAGE4 protein affects the susceptibility to Mitoxantrone

G

G antigen 6

affects response to substance

GAGE6 protein affects the susceptibility to Mitoxantrone

G

G antigen 7

affects response to substance

GAGE7 protein affects the susceptibility to Mitoxantrone

Ensembl chr X:49,551,278...49,568,218
Ensembl chr X:49,551,278...49,568,218

G

GTP cyclohydrolase 1

affects response to substance

GCH1 protein affects the susceptibility to Mitoxantrone

NCBI chr14:54,842,017...54,902,826
Ensembl chr14:54,842,008...54,902,826

G

growth differentiation factor 15

increases expression

Mitoxantrone results in increased expression of GDF15 mRNA

PMID:26537877 PMID:28940058

NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176

G

glutamate-ammonia ligase

affects response to substance

GLUL protein affects the susceptibility to Mitoxantrone

NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,378,098...182,392,206

G

glutathione peroxidase 1

increases expression

Mitoxantrone results in increased expression of GPX1 mRNA

PMID:26537877 PMID:28940058

NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605

G

glutathione peroxidase 3

affects response to substance

GPX3 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988

G

guanylate cyclase 1 soluble subunit beta 1

affects response to substance

GUCY1B1 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:155,759,021...155,807,811
Ensembl chr 4:155,758,992...155,807,811

G

H2A.X variant histone

increases expression
increases phosphorylation
multiple interactions

Mitoxantrone results in increased expression of H2AX protein
Mitoxantrone results in increased phosphorylation of H2AX protein
Poly(ADP-ribose) Polymerase Inhibitors affects the reaction [Mitoxantrone results in increased expression of H2AX protein]

PMID:19738048 PMID:24994473 PMID:29913208

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

decreases expression

Mitoxantrone results in decreased expression of HADHB protein

NCBI chr 2:26,244,939...26,290,465
Ensembl chr 2:26,243,170...26,290,465

G

histone deacetylase 4

affects response to substance

HDAC4 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:239,048,168...239,401,649
Ensembl chr 2:239,048,168...239,401,654

G

major histocompatibility complex, class II, DR beta 5

affects response to substance

HLA-DRB5 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:32,517,353...32,530,287
Ensembl chr 6:32,517,353...32,530,287

G

high mobility group 20B

affects response to substance

HMG20B protein affects the susceptibility to Mitoxantrone

NCBI chr19:3,572,944...3,579,083
Ensembl chr19:3,572,777...3,579,088

G

homeobox A5

affects response to substance

HOXA5 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:27,141,052...27,143,681
Ensembl chr 7:27,141,052...27,143,681

G

histidine rich calcium binding protein

decreases expression

Mitoxantrone results in decreased expression of HRC mRNA

PMID:26537877 PMID:28940058

NCBI chr19:49,151,198...49,155,396
Ensembl chr19:49,151,198...49,155,396

G

heat shock protein family A (Hsp70) member 2

affects response to substance

HSPA2 protein affects the susceptibility to Mitoxantrone

NCBI chr14:64,535,905...64,543,237
Ensembl chr14:64,535,905...64,546,173

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

affects response to substance
decreases expression

IDH3A protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in decreased expression of IDH3A protein

PMID:16217747 PMID:34246718

NCBI chr15:78,149,362...78,171,945
Ensembl chr15:78,131,498...78,171,945

G

interferon induced transmembrane protein 1

affects response to substance

IFITM1 protein affects the susceptibility to Mitoxantrone

NCBI chr11:314,040...315,272
Ensembl chr11:310,041...315,272

G

insulin like growth factor 1 receptor

affects response to substance

IGF1R protein affects the susceptibility to Mitoxantrone

NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530

G

insulin like growth factor 2 mRNA binding protein 3

affects response to substance

IGF2BP3 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:23,310,209...23,470,491
Ensembl chr 7:23,310,209...23,470,491

G

insulin like growth factor binding protein 3

affects response to substance

IGFBP3 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874

G

insulin like growth factor binding protein 7

affects response to substance

IGFBP7 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:57,030,773...57,110,385
Ensembl chr 4:57,030,773...57,110,385

G

interleukin 13 receptor subunit alpha 2

affects response to substance

IL13RA2 protein affects the susceptibility to Mitoxantrone

NCBI chr X:115,003,982...115,017,616
Ensembl chr X:115,003,975...115,019,977

G

inner membrane mitochondrial protein

decreases expression

Mitoxantrone results in decreased expression of IMMT protein

NCBI chr 2:86,143,936...86,195,462
Ensembl chr 2:86,143,932...86,195,472

G

IQ motif containing GTPase activating protein 1

affects response to substance

IQGAP1 protein affects the susceptibility to Mitoxantrone

NCBI chr15:90,388,242...90,502,239
Ensembl chr15:90,388,242...90,502,239

G

interferon regulatory factor 7

affects response to substance

IRF7 protein affects the susceptibility to Mitoxantrone

NCBI chr11:612,555...615,950
Ensembl chr11:612,553...615,983

G

iroquois homeobox 1

affects response to substance

IRX1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 5:3,595,832...3,601,403
Ensembl chr 5:3,595,832...3,601,403

G

iroquois homeobox 4

decreases expression

Mitoxantrone results in decreased expression of IRX4 mRNA

PMID:26537877 PMID:28940058

NCBI chr 5:1,877,413...1,887,179
Ensembl chr 5:1,877,413...1,887,236

G

ISG15 ubiquitin like modifier

affects response to substance

ISG15 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:1,013,497...1,014,540
Ensembl chr 1:1,001,138...1,014,540

G

interferon stimulated exonuclease gene 20

affects response to substance

ISG20 protein affects the susceptibility to Mitoxantrone

NCBI chr15:88,635,632...88,656,483
Ensembl chr15:88,635,670...88,656,483

G

Janus kinase 2

decreases expression

Mitoxantrone results in decreased expression of JAK2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in increased expression of JUN mRNA]

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

potassium voltage-gated channel subfamily A regulatory beta subunit 2

affects response to substance

KCNAB2 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:5,992,676...6,101,180
Ensembl chr 1:5,990,927...6,101,193

G

potassium voltage-gated channel subfamily H member 2

decreases expression

Mitoxantrone results in decreased expression of KCNH2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

G

potassium inwardly rectifying channel subfamily J member 2

increases expression

Mitoxantrone results in increased expression of KCNJ2 mRNA

PMID:26537877 PMID:28940058

NCBI chr17:70,169,532...70,180,044
Ensembl chr17:70,168,673...70,180,044

G

potassium voltage-gated channel subfamily Q member 1

decreases expression

Mitoxantrone results in decreased expression of KCNQ1 mRNA

PMID:26537877 PMID:28940058

NCBI chr11:2,445,008...2,849,105
Ensembl chr11:2,444,654...2,849,105

G

KRR1 small subunit processome component homolog

affects response to substance

KRR1 protein affects the susceptibility to Mitoxantrone

NCBI chr12:75,490,863...75,511,609
Ensembl chr12:75,490,863...75,511,636

G

KRT10 antisense RNA 1

affects response to substance

KRT10-AS1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr17:40,819,145...40,836,274
Ensembl chr17:40,819,101...40,836,270

G

laminin subunit alpha 2

affects response to substance

LAMA2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 6:128,883,138...129,516,566
Ensembl chr 6:128,883,138...129,516,566

G

laminin subunit beta 1

affects response to substance

LAMB1 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:107,923,799...108,003,161
Ensembl chr 7:107,923,799...108,003,213

G

laminin subunit gamma 1

affects response to substance

LAMC1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:183,023,420...183,145,592
Ensembl chr 1:183,023,420...183,145,592

G

LBH regulator of WNT signaling pathway

affects response to substance

LBH protein affects the susceptibility to Mitoxantrone

NCBI chr 2:30,231,534...30,260,028
Ensembl chr 2:30,231,534...30,323,730

G

LIM domain binding 3

decreases expression

Mitoxantrone results in decreased expression of LDB3 mRNA

PMID:26537877 PMID:28940058

NCBI chr10:86,666,788...86,736,072
Ensembl chr10:86,666,785...86,736,072

G

LEM domain nuclear envelope protein 2

affects response to substance

LEMD2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 6:33,771,213...33,789,130
Ensembl chr 6:33,771,202...33,789,130

G

leucine rich repeat containing G protein-coupled receptor 4

affects response to substance

LGR4 protein affects the susceptibility to Mitoxantrone

NCBI chr11:27,365,961...27,472,790
Ensembl chr11:27,365,961...27,472,790

G

lipase A, lysosomal acid type

affects response to substance

LIPA protein affects the susceptibility to Mitoxantrone

NCBI chr10:89,213,572...89,251,775
Ensembl chr10:89,213,569...89,414,557

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lipase G, endothelial type

affects response to substance

LIPG protein affects the susceptibility to Mitoxantrone

NCBI chr18:49,561,479...49,599,185
Ensembl chr18:49,560,699...49,599,185

G

LIM and cysteine rich domains 1

increases expression

Mitoxantrone results in increased expression of LMCD1 mRNA

NCBI chr 3:8,501,823...8,574,668
Ensembl chr 3:8,501,807...8,574,668

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lamin B1

multiple interactions

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein

NCBI chr 5:126,776,623...126,837,020
Ensembl chr 5:126,776,623...126,837,020

G

mono-ADP ribosylhydrolase 1

affects response to substance

MACROD1 protein affects the susceptibility to Mitoxantrone

NCBI chr11:63,998,558...64,166,113
Ensembl chr11:63,998,558...64,166,113

G

MAF bZIP transcription factor F

affects response to substance

MAFF mRNA affects the susceptibility to Mitoxantrone

NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507

G

MAGE family member A6

affects response to substance

MAGEA6 protein affects the susceptibility to Mitoxantrone

NCBI chr X:152,766,136...152,769,689
Ensembl chr X:152,766,136...152,769,716

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MAGE family member D1

affects response to substance

MAGED1 protein affects the susceptibility to Mitoxantrone

NCBI chr X:51,803,076...51,902,354
Ensembl chr X:51,803,007...51,902,354

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MAGE family member D4B

affects response to substance

MAGED4B protein affects the susceptibility to Mitoxantrone

NCBI chr X:52,061,827...52,069,272
Ensembl chr X:52,061,827...52,069,219

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microtubule associated protein 1 light chain 3 beta

multiple interactions

Mitoxantrone results in decreased expression of and results in increased lipidation of MAP1LC3B protein

NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779

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malate dehydrogenase 2

decreases expression

Mitoxantrone results in decreased expression of MDH2 protein

NCBI chr 7:76,048,106...76,067,508
Ensembl chr 7:76,048,051...76,067,508

G

MDM2 proto-oncogene

decreases response to substance

MDM2 promoter SNP results in decreased susceptibility to Mitoxantrone

NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544

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mesoderm specific transcript

affects response to substance

MEST protein affects the susceptibility to Mitoxantrone

NCBI chr 7:130,486,175...130,506,465
Ensembl chr 7:130,486,171...130,506,465

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microRNA 654

increases response to substance

MIR654 mRNA results in increased susceptibility to Mitoxantrone

NCBI chr14:101,040,219...101,040,299
Ensembl chr14:101,040,219...101,040,299

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microRNA 765

increases response to substance

MIR765 mRNA results in increased susceptibility to Mitoxantrone

NCBI chr 1:156,936,131...156,936,244
Ensembl chr 1:156,936,131...156,936,244

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molybdenum cofactor sulfurase

affects response to substance

MOCOS protein affects the susceptibility to Mitoxantrone

NCBI chr18:36,187,497...36,272,157
Ensembl chr18:36,187,497...36,272,157

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mitochondrial pyruvate carrier 2

affects response to substance

MPC2 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:167,916,675...167,937,072
Ensembl chr 1:167,916,675...167,937,072

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methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

affects response to substance

MTHFD2 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:74,198,615...74,217,565
Ensembl chr 2:74,186,172...74,217,565

G

MAX interactor 1, dimerization protein

affects response to substance

MXI1 protein affects the susceptibility to Mitoxantrone

NCBI chr10:110,207,605...110,287,365
Ensembl chr10:110,207,605...110,287,365

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
multiple interactions

Mitoxantrone results in decreased expression of MYC mRNA
Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in decreased expression of MYC mRNA]

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

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MYC binding protein 2

affects response to substance

MYCBP2 protein affects the susceptibility to Mitoxantrone

NCBI chr13:77,044,657...77,327,094
Ensembl chr13:77,042,474...77,327,094

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myosin heavy chain 6

decreases expression

Mitoxantrone results in decreased expression of MYH6 mRNA

PMID:26537877 PMID:28940058

NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273

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myosin heavy chain 7

decreases expression

Mitoxantrone results in decreased expression of MYH7 mRNA

PMID:26537877 PMID:28940058

NCBI chr14:23,412,740...23,435,660
Ensembl chr14:23,412,740...23,435,660

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myomesin 2

decreases expression

Mitoxantrone results in decreased expression of MYOM2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 8:2,045,046...2,145,456
Ensembl chr 8:2,045,046...2,165,552

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nicotinamide phosphoribosyltransferase

affects response to substance

NAMPT protein affects the susceptibility to Mitoxantrone

NCBI chr 7:106,248,298...106,285,888
Ensembl chr 7:106,248,298...106,285,966

G

NADH:ubiquinone oxidoreductase subunit S5

affects response to substance

NDUFS5 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:39,026,350...39,034,615
Ensembl chr 1:39,026,318...39,034,636

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neurofilament heavy chain

affects response to substance

NEFH protein affects the susceptibility to Mitoxantrone

NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390

G

nidogen 2

affects response to substance

NID2 protein affects the susceptibility to Mitoxantrone

NCBI chr14:52,004,809...52,069,059
Ensembl chr14:52,004,809...52,069,059

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nuclear receptor subfamily 3 group C member 1

decreases activity

Mitoxantrone results in decreased activity of NR3C1 protein

NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512

G

nuclear receptor subfamily 4 group A member 2

affects response to substance

NR4A2 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:156,324,437...156,332,721
Ensembl chr 2:156,324,437...156,342,348

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nebulin related anchoring protein

decreases expression

Mitoxantrone results in decreased expression of NRAP mRNA

PMID:26537877 PMID:28940058

NCBI chr10:113,588,714...113,664,041
Ensembl chr10:113,588,714...113,664,070

G

nuclear receptor interacting protein 1

affects response to substance

NRIP1 protein affects the susceptibility to Mitoxantrone

NCBI chr21:14,961,235...15,065,936
Ensembl chr21:14,961,235...15,065,936

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3-oxoacid CoA-transferase 1

affects response to substance

OXCT1 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:41,730,065...41,870,425
Ensembl chr 5:41,730,065...41,870,425

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prolyl 4-hydroxylase subunit alpha 1

affects response to substance

P4HA1 protein affects the susceptibility to Mitoxantrone

NCBI chr10:73,007,217...73,096,866
Ensembl chr10:73,007,217...73,096,974

G

parkin coregulated like

affects response to substance

PACRGL mRNA affects the susceptibility to Mitoxantrone

NCBI chr 4:20,696,282...20,767,373
Ensembl chr 4:20,696,282...20,752,907

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poly(ADP-ribose) polymerase 1

multiple interactions

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]

PMID:8840993 PMID:15582267

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

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PBX homeobox 1

affects response to substance

PBX1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:164,559,184...164,886,047
Ensembl chr 1:164,555,584...164,899,296

G

phosphodiesterase 4D

affects response to substance

PDE4D protein affects the susceptibility to Mitoxantrone

NCBI chr 5:58,969,038...60,522,128
Ensembl chr 5:58,969,038...60,522,120

G

phosphodiesterase 8A

affects response to substance

PDE8A protein affects the susceptibility to Mitoxantrone

NCBI chr15:84,980,467...85,139,142
Ensembl chr15:84,980,440...85,139,145

G

pyruvate dehydrogenase E1 subunit alpha 1

decreases expression

Mitoxantrone results in decreased expression of PDHA1 protein

NCBI chr X:19,343,927...19,361,718
Ensembl chr X:19,343,893...19,361,718

G

prohibitin 2

decreases expression

Mitoxantrone results in decreased expression of PHB2 protein

NCBI chr12:6,965,327...6,970,753
Ensembl chr12:6,965,327...6,970,780

G

phosphoglycerate dehydrogenase

affects response to substance

PHGDH protein affects the susceptibility to Mitoxantrone

NCBI chr 1:119,711,934...119,744,215
Ensembl chr 1:119,648,411...119,744,218

G

PLAG1 like zinc finger 1

affects response to substance

PLAGL1 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:143,940,300...144,064,599
Ensembl chr 6:143,940,300...144,064,599

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plasminogen activator, tissue type

affects response to substance

PLAT protein affects the susceptibility to Mitoxantrone

NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709

G

phospholipase C beta 4

affects response to substance

PLCB4 protein affects the susceptibility to Mitoxantrone

NCBI chr20:9,068,678...9,480,808
Ensembl chr20:9,067,825...9,504,593

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pyridoxal phosphate binding protein

affects response to substance

PLPBP protein affects the susceptibility to Mitoxantrone

NCBI chr 8:37,762,546...37,779,768
Ensembl chr 8:37,762,595...37,779,768

G

PML nuclear body scaffold

affects mutagenesis

Mitoxantrone affects the mutagenesis of PML gene

NCBI chr15:73,994,716...74,047,827
Ensembl chr15:73,994,673...74,047,827

G

POM121 and ZP3 fusion

affects response to substance

POMZP3 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:76,609,986...76,627,279
Ensembl chr 7:76,609,986...76,627,279

G

protein phosphatase 1 regulatory inhibitor subunit 2

affects response to substance

PPP1R2 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:195,514,428...195,543,325
Ensembl chr 3:195,514,428...195,543,386

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protein phosphatase 1 regulatory subunit 3A

decreases expression

Mitoxantrone results in decreased expression of PPP1R3A mRNA

PMID:26537877 PMID:28940058

NCBI chr 7:113,876,777...113,919,009
Ensembl chr 7:113,876,777...114,075,920

G

PR/SET domain 16

decreases expression

Mitoxantrone results in decreased expression of PRDM16 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:3,069,203...3,438,621
Ensembl chr 1:3,069,168...3,438,621

G

peroxiredoxin 2

affects response to substance

PRDX2 protein affects the susceptibility to Mitoxantrone

NCBI chr19:12,796,823...12,801,800
Ensembl chr19:12,796,820...12,801,800

G

PRELI domain containing 3B

affects response to substance

PRELID3B protein affects the susceptibility to Mitoxantrone

NCBI chr20:59,033,145...59,042,786
Ensembl chr20:59,033,145...59,042,809

G

protein kinase cAMP-dependent X-linked catalytic subunit

increases expression

Mitoxantrone results in increased expression of PRKX mRNA

PMID:26537877 PMID:28940058

NCBI chr X:3,604,340...3,713,649
Ensembl chr X:3,604,340...3,713,649

G

protein tyrosine phosphatase receptor type E

affects response to substance

PTPRE protein affects the susceptibility to Mitoxantrone

NCBI chr10:127,907,103...128,085,855
Ensembl chr10:127,907,103...128,085,855

G

glycogen phosphorylase, muscle associated

decreases expression

Mitoxantrone results in decreased expression of PYGM mRNA

PMID:26537877 PMID:28940058

NCBI chr11:64,746,389...64,760,715
Ensembl chr11:64,746,389...64,759,974

G

retinoic acid receptor alpha

affects mutagenesis

Mitoxantrone affects the mutagenesis of RARA gene

NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643

G

retinoic acid receptor beta

increases expression

Mitoxantrone results in increased expression of RARB mRNA alternative form

NCBI chr 3:24,829,321...25,597,932
Ensembl chr 3:24,687,887...25,597,932

G

RAS p21 protein activator 1

affects response to substance

RASA1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 5:87,267,883...87,391,916
Ensembl chr 5:87,267,883...87,391,931

G

RB binding protein 8, endonuclease

affects response to substance

RBBP8 protein affects the susceptibility to Mitoxantrone

NCBI chr18:22,914,139...23,026,486
Ensembl chr18:22,798,261...23,026,488

G

RNA binding motif protein 17

multiple interactions
decreases response to substance

LY 117018 inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]; Tamoxifen inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]

NCBI chr10:6,089,034...6,117,447
Ensembl chr10:6,089,034...6,117,457

G

RCC1 and BTB domain containing protein 1

affects response to substance

RCBTB1 protein affects the susceptibility to Mitoxantrone

NCBI chr13:49,531,946...49,585,558
Ensembl chr13:49,531,946...49,585,558

G

ring finger and CHY zinc finger domain containing 1

affects response to substance

RCHY1 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:75,479,033...75,514,715
Ensembl chr 4:75,479,033...75,514,764

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regulator of G protein signaling 2

affects response to substance

RGS2 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275

G

Rho family GTPase 1

increases expression

Mitoxantrone results in increased expression of RND1 mRNA

NCBI chr12:48,857,145...48,865,870
Ensembl chr12:48,857,145...48,865,870

G

Ras related GTP binding D

affects response to substance

RRAGD mRNA affects the susceptibility to Mitoxantrone

NCBI chr 6:89,364,616...89,412,273
Ensembl chr 6:89,364,616...89,412,273

G

RUNX family transcription factor 3

affects response to substance

RUNX3 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:24,899,511...24,965,138
Ensembl chr 1:24,899,511...24,965,121

G

ryanodine receptor 2

decreases expression

Mitoxantrone results in decreased expression of RYR2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988

G

S100 calcium binding protein P

affects response to substance

S100P protein affects the susceptibility to Mitoxantrone

NCBI chr 4:6,693,878...6,697,170
Ensembl chr 4:6,693,878...6,697,170

G

spalt like transcription factor 2

affects response to substance

SALL2 protein affects the susceptibility to Mitoxantrone

NCBI chr14:21,521,080...21,537,121
Ensembl chr14:21,521,080...21,537,216

G

SATB homeobox 2

affects response to substance

SATB2 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:199,269,500...199,471,266
Ensembl chr 2:199,269,505...199,471,266

G

stearoyl-CoA desaturase

affects response to substance

SCD protein affects the susceptibility to Mitoxantrone

NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826

G

schwannomin interacting protein 1

affects response to substance

SCHIP1 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:159,273,244...159,897,359
Ensembl chr 3:159,839,861...159,897,360
Ensembl chr 3:159,839,861...159,897,360

G

sodium voltage-gated channel beta subunit 2

decreases expression

Mitoxantrone results in decreased expression of SCN2B mRNA

PMID:26537877 PMID:28940058

NCBI chr11:118,162,806...118,176,639
Ensembl chr11:118,162,806...118,176,639

G

sodium voltage-gated channel alpha subunit 5

decreases expression

Mitoxantrone results in decreased expression of SCN5A mRNA

PMID:26537877 PMID:28940058

NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,687

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syndecan 2

affects response to substance

SDC2 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:96,493,813...96,611,790
Ensembl chr 8:96,493,813...96,611,790

G

SEC31 homolog A, COPII coat complex component

affects response to substance

SEC31A protein affects the susceptibility to Mitoxantrone

NCBI chr 4:82,818,509...82,900,569
Ensembl chr 4:82,818,509...82,901,166

G

serpin family E member 1

increases expression

Mitoxantrone results in increased expression of SERPINE1 mRNA

NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247

G

stratifin

affects response to substance

SFN protein affects the susceptibility to Mitoxantrone

NCBI chr 1:26,863,149...26,864,456
Ensembl chr 1:26,863,149...26,864,456

G

secreted frizzled related protein 4

affects response to substance

SFRP4 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 7:37,905,932...37,916,817
Ensembl chr 7:37,905,932...38,025,695

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solute carrier family 16 member 6

affects response to substance

SLC16A6 protein affects the susceptibility to Mitoxantrone

NCBI chr17:68,267,026...68,291,479
Ensembl chr17:68,267,026...68,291,267

G

solute carrier family 25 member 11

decreases expression

Mitoxantrone results in decreased expression of SLC25A11 protein

NCBI chr17:4,937,130...4,940,046
Ensembl chr17:4,937,130...4,940,053

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solute carrier family 7 member 5

affects response to substance

SLC7A5 protein affects the susceptibility to Mitoxantrone

NCBI chr16:87,830,023...87,869,507
Ensembl chr16:87,830,023...87,869,507

G

solute carrier organic anion transporter family member 4A1

affects response to substance

SLCO4A1 protein affects the susceptibility to Mitoxantrone

NCBI chr20:62,642,503...62,690,740
Ensembl chr20:62,642,503...62,685,785

G

SMAD family member 2

affects response to substance

SMAD2 protein affects the susceptibility to Mitoxantrone

NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146

G

sorbin and SH3 domain containing 1

affects response to substance

SORBS1 protein affects the susceptibility to Mitoxantrone

NCBI chr10:95,311,773...95,561,371
Ensembl chr10:95,311,771...95,561,414

G

spondin 1

affects response to substance

SPON1 protein affects the susceptibility to Mitoxantrone

NCBI chr11:13,962,723...14,268,133
Ensembl chr11:13,962,723...14,268,133

G

spondin 2

affects response to substance

SPON2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:1,166,932...1,208,844
Ensembl chr 4:1,166,932...1,208,962

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secreted phosphoprotein 1

increases expression

Mitoxantrone results in increased expression of SPP1 mRNA

NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532

G

sequestosome 1

decreases expression
affects expression

Mitoxantrone metabolite results in decreased expression of SQSTM1 protein
Mitoxantrone affects the expression of SQSTM1 protein

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

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steroid 5 alpha-reductase 1

affects response to substance

SRD5A1 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:6,633,440...6,674,386
Ensembl chr 5:6,633,290...6,676,539

G

succinate-CoA ligase ADP-forming subunit beta

decreases expression

Mitoxantrone results in decreased expression of SUCLA2 protein

NCBI chr13:47,942,656...48,001,273
Ensembl chr13:47,745,736...48,037,968

G

synaptotagmin like 2

affects response to substance

SYTL2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr11:85,694,229...85,854,870
Ensembl chr11:85,694,224...85,811,159

G

transgelin

affects response to substance

TAGLN protein affects the susceptibility to Mitoxantrone

NCBI chr11:117,199,294...117,207,465
Ensembl chr11:117,199,370...117,207,464

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transporter 1, ATP binding cassette subfamily B member

affects response to substance

TAP1 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:32,845,209...32,853,704
Ensembl chr 6:32,845,209...32,853,816

G

TBC1 domain family member 8

affects response to substance

TBC1D8 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:101,007,228...101,151,382
Ensembl chr 2:101,007,228...101,252,866

G

trefoil factor 3

affects response to substance

TFF3 protein affects the susceptibility to Mitoxantrone

NCBI chr21:42,311,667...42,315,409
Ensembl chr21:42,311,667...42,315,409

G

transforming growth factor beta 2

increases expression

Mitoxantrone results in increased expression of TGFB2 mRNA

NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619

G

TIA1 cytotoxic granule associated RNA binding protein

affects response to substance

TIA1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:70,209,444...70,248,793
Ensembl chr 2:70,209,444...70,248,660

G

TIMP metallopeptidase inhibitor 1

increases expression

Mitoxantrone results in increased expression of TIMP1 mRNA

NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789

G

transmembrane protein 47

affects response to substance

TMEM47 protein affects the susceptibility to Mitoxantrone

NCBI chr X:34,627,075...34,657,285
Ensembl chr X:34,627,075...34,657,285

G

tankyrase

affects response to substance

TNKS protein affects the susceptibility to Mitoxantrone

NCBI chr 8:9,555,912...9,782,346
Ensembl chr 8:9,555,912...9,782,346

G

troponin T1, slow skeletal type

decreases expression

Mitoxantrone results in decreased expression of TNNT1 mRNA

PMID:26537877 PMID:28940058

NCBI chr19:55,132,698...55,149,206
Ensembl chr19:55,132,698...55,149,206

G

tumor protein p53

affects activity

Mitoxantrone affects the activity of TP53 protein

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

tumor protein D52

affects response to substance

TPD52 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:80,031,082...80,171,564
Ensembl chr 8:80,034,745...80,231,232

G

tropomyosin 1

affects response to substance

TPM1 protein affects the susceptibility to Mitoxantrone

NCBI chr15:63,042,747...63,071,915
Ensembl chr15:63,042,620...63,071,915

G

tribbles pseudokinase 1

affects response to substance

TRIB1 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:125,430,358...125,438,403
Ensembl chr 8:125,430,358...125,438,403

G

tripartite motif containing 2

affects response to substance

TRIM2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:153,152,163...153,339,317
Ensembl chr 4:153,152,163...153,339,319

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ubiquitin like 3

affects response to substance

UBL3 protein affects the susceptibility to Mitoxantrone

NCBI chr13:29,764,371...29,850,617
Ensembl chr13:29,764,371...29,850,617

G

ubiquitin C-terminal hydrolase L1

affects response to substance

UCHL1 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:41,256,928...41,268,455
Ensembl chr 4:41,256,413...41,268,455

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ubiquinol-cytochrome c reductase hinge protein

affects response to substance

UQCRH protein affects the susceptibility to Mitoxantrone

NCBI chr 1:46,303,698...46,316,776
Ensembl chr 1:46,303,698...46,316,776

G

utrophin

affects response to substance

UTRN protein affects the susceptibility to Mitoxantrone

NCBI chr 6:144,285,335...144,853,034
Ensembl chr 6:144,285,335...144,853,034

G

versican

affects response to substance

VCAN protein affects the susceptibility to Mitoxantrone

NCBI chr 5:83,471,744...83,582,302
Ensembl chr 5:83,471,618...83,582,303

G

voltage dependent anion channel 1

decreases expression

Mitoxantrone results in decreased expression of VDAC1 protein

NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975

G

tryptophanyl-tRNA synthetase 1

affects response to substance

WARS1 protein affects the susceptibility to Mitoxantrone

NCBI chr14:100,333,790...100,376,327
Ensembl chr14:100,333,790...100,376,805

G

WASH complex subunit 3

affects response to substance

WASHC3 protein affects the susceptibility to Mitoxantrone

NCBI chr12:102,012,840...102,062,124
Ensembl chr12:102,012,840...102,062,149

G

X-linked inhibitor of apoptosis

affects localization
decreases expression

Mitoxantrone affects the localization of XIAP protein
Mitoxantrone results in decreased expression of XIAP protein

NCBI chr X:123,859,708...123,913,972
Ensembl chr X:123,859,712...123,913,972

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

increases expression

Mitoxantrone results in increased expression of YWHAE protein

NCBI chr17:1,344,275...1,400,222
Ensembl chr17:1,344,275...1,400,222

G

zinc finger AN1-type containing 1

affects response to substance

ZFAND1 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:81,701,331...81,721,304
Ensembl chr 8:81,701,334...81,732,903

G

zinc finger matrin-type 3

increases expression

Mitoxantrone results in increased expression of ZMAT3 mRNA

PMID:26537877 PMID:28940058

NCBI chr 3:179,017,223...179,072,513
Ensembl chr 3:178,960,121...179,072,215

G

zinc finger and SCAN domain containing 18

affects response to substance

ZSCAN18 protein affects the susceptibility to Mitoxantrone

NCBI chr19:58,083,842...58,118,426
Ensembl chr19:58,083,838...58,118,427

Obtusifolin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 6

decreases activity

obtusifolin results in decreased activity of SLC22A6 protein

NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967

G

solute carrier family 22 member 8

decreases activity

obtusifolin results in decreased activity of SLC22A8 protein

NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841

physcion

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

increases expression

physcione results in increased expression of ABCB11 mRNA; physcione results in increased expression of ABCB11 protein

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ATP binding cassette subfamily B member 4

decreases expression

physcione results in decreased expression of ABCB4 mRNA

NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435

G

ATP binding cassette subfamily C member 2

decreases expression

physcione results in decreased expression of ABCC2 mRNA; physcione results in decreased expression of ABCC2 protein

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ATP binding cassette subfamily C member 3

decreases expression

physcione results in decreased expression of ABCC3 mRNA; physcione results in decreased expression of ABCC3 protein

NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253

G

BCL2 associated X, apoptosis regulator

increases expression
decreases expression

physcione results in increased expression of BAX protein
physcione results in decreased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

physcione results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:33438235

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 21 subfamily A member 2

increases hydroxylation

CYP21A2 protein results in increased hydroxylation of physcione

NCBI chr 6:32,038,415...32,041,644
Ensembl chr 6:32,038,327...32,041,644

G

cytochrome P450 family 27 subfamily A member 1

decreases expression

physcione results in decreased expression of CYP27A1 mRNA

NCBI chr 2:218,782,147...218,815,293
Ensembl chr 2:218,781,749...218,815,293

G

cytochrome P450 family 2 subfamily B member 6

increases hydroxylation

CYP2B6 protein results in increased hydroxylation of physcione

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

G

cytochrome P450 family 2 subfamily C member 19

increases hydroxylation

CYP2C19 protein results in increased hydroxylation of physcione

NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547

G

cytochrome P450 family 3 subfamily A member 4

increases hydroxylation

CYP3A4 protein results in increased hydroxylation of physcione

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

physcione results in decreased expression of CYP8B1 mRNA; physcione results in decreased expression of CYP8B1 protein

NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898

G

solute carrier family 10 member 1

decreases expression

physcione results in decreased expression of SLC10A1 mRNA; physcione results in decreased expression of SLC10A1 protein

NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241

G

sulfotransferase family 1A member 1

decreases activity

physcione results in decreased activity of SULT1A1 protein

NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of physcione

NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300

quinizarin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

1,4-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

albumin

affects binding

1,4-dihydroxyanthraquinone binds to ALB protein

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

1,4-dihydroxyanthraquinone results in decreased activity of CYP1A2 protein

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

estrogen receptor 1

multiple interactions

1,4-dihydroxyanthraquinone binds to and results in increased activity of ESR1 protein

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone

NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300

G

UDP glucuronosyltransferase family 1 member A10

increases glucuronidation

UGT1A10 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone

NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300

G

UDP glucuronosyltransferase family 1 member A7

increases glucuronidation

UGT1A7 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone

NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300

G

UDP glucuronosyltransferase family 1 member A8

increases glucuronidation

UGT1A8 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone

NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone

NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300

Rhein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

Enzymes and Coenzymes inhibits the reaction [rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; rhein metabolite inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

actin alpha 2, smooth muscle

multiple interactions

rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339

G

adhesion G protein-coupled receptor E1

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 protein]

NCBI chr19:6,887,579...6,940,450
Ensembl chr19:6,887,566...6,940,459

G

aryl hydrocarbon receptor

multiple interactions

rhein inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

alkB homolog 2, alpha-ketoglutarate dependent dioxygenase

decreases activity

rhein results in decreased activity of ALKBH2 protein

NCBI chr12:109,088,189...109,093,472
Ensembl chr12:109,088,188...109,093,631

G

BCL2 associated X, apoptosis regulator

increases expression

rhein results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

beclin 1

decreases expression

rhein results in decreased expression of BECN1 protein

NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350

G

caspase 1

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased cleavage of CASP1 protein]

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 3

decreases expression

rhein results in decreased expression of CASP3 protein

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

increases cleavage

rhein results in increased cleavage of CASP8 protein

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

decreases expression

rhein results in decreased expression of CASP9 protein

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

cytochrome P450 family 1 subfamily A member 1

decreases activity

rhein results in decreased activity of CYP1A1 protein

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

rhein results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:33438235

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 2 subfamily C member 19

decreases activity

rhein results in decreased activity of CYP2C19 protein

NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547

G

cytochrome P450 family 2 subfamily C member 9

decreases activity

rhein results in decreased activity of CYP2C9 protein

PMID:27633141 PMID:33438235

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 2 subfamily D member 6

decreases activity

rhein results in decreased activity of CYP2D6 protein

NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865

G

epidermal growth factor

decreases expression

rhein results in decreased expression of EGF protein

NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766

G

erb-b2 receptor tyrosine kinase 2

decreases expression

rhein results in decreased expression of ERBB2 protein

NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426

G

glutamic--pyruvic transaminase

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

hypoxia inducible factor 1 subunit alpha

decreases expression
multiple interactions

rhein results in decreased expression of HIF1A protein
rhein inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]

NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259

G

interferon gamma

multiple interactions
increases expression

rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]
rhein results in increased expression of IFNG protein

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

interleukin 10

multiple interactions

rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 17A

increases expression

rhein results in increased expression of IL17A protein

NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638

G

interleukin 18

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL18 protein]

NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096

G

interleukin 1 beta

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 2

increases expression

rhein results in increased expression of IL2 protein

NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725

G

interleukin 6

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

PMID:26784856 PMID:37023836

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

nuclear factor kappa B subunit 1

affects localization
multiple interactions
decreases activity

rhein affects the localization of NFKB1 protein
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NFKB1 mRNA]
rhein results in decreased activity of NFKB1 protein

PMID:21457705 PMID:37023836

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NLR family pyrin domain containing 3

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA]

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108

G

prostaglandin-endoperoxide synthase 2

decreases expression

rhein results in decreased expression of PTGS2 protein

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

RELA proto-oncogene, NF-kB subunit

decreases activity
multiple interactions
affects localization

rhein results in decreased activity of RELA protein
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of RELA protein]
cobaltous chloride promotes the reaction [rhein affects the localization of RELA protein]

PMID:21457705 PMID:37023836

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

solute carrier family 22 member 6

multiple interactions

rhein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]

NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967

G

solute carrier family 22 member 8

multiple interactions

rhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]

NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841

G

sequestosome 1

increases expression

rhein results in increased expression of SQSTM1 protein

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

sulfotransferase family 1A member 1

decreases activity

rhein results in decreased activity of SULT1A1 protein

NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044

G

transforming growth factor beta 1

multiple interactions

rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

tumor necrosis factor

increases expression
multiple interactions

rhein results in increased expression of TNF protein
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; rhein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:26784856 PMID:31436023 PMID:37023836

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNFRSF1A associated via death domain

increases expression

rhein results in increased expression of TRADD protein

NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909

G

TNF receptor associated factor 1

increases expression

rhein results in increased expression of TRAF1 protein

NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173

G

vascular endothelial growth factor A

decreases expression
decreases response to substance

rhein results in decreased expression of VEGFA protein
rhein results in decreased susceptibility to VEGFA protein

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

rubiadin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbonic anhydrase 2

decreases expression

rubiadin results in decreased expression of CA2 mRNA

NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493

G

calcitonin receptor

decreases expression

rubiadin results in decreased expression of CALCR mRNA

NCBI chr 7:93,424,486...93,574,724
Ensembl chr 7:93,424,486...93,574,730

G

cathepsin K

increases activity

rubiadin results in increased activity of CTSK protein

NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

rubiadin results in decreased activity of CYP1A2 protein

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 2 subfamily C member 19

decreases activity

rubiadin results in decreased activity of CYP2C19 protein

NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547

G

cytochrome P450 family 2 subfamily C member 9

decreases activity

rubiadin results in decreased activity of CYP2C9 protein

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 2 subfamily D member 6

decreases activity

rubiadin results in decreased activity of CYP2D6 protein

NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865

G

NFKB inhibitor alpha

multiple interactions

rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

TNF receptor superfamily member 11b

increases expression

rubiadin results in increased expression of TNFRSF11B mRNA; rubiadin results in increased expression of TNFRSF11B protein

NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885

G

TNF superfamily member 11

decreases expression
multiple interactions

rubiadin results in decreased expression of TNFSF11 mRNA; rubiadin results in decreased expression of TNFSF11 protein
rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]

NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26041
chemical entity	26020
molecular entity	25998
polyatomic entity	25883
heteroatomic molecular entity	25534
hydroxides	24056
organic hydroxy compound	22071
phenols	21112
hydroxyanthraquinones	522
dihydroxyanthraquinone	370
1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(3'-O-acetyl)-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3-dihydroxy-6-methoxy-2-methyl-9,10-anthraquinone	0
1,4-dihydroxy-2-methylanthraquinone	0
1,6-dihydroxy-2-methyl-9,10-anthraquinone	0
3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid	1
4'-O-demethylknipholone-4'-O-beta-D-glucopyranoside	0
Aloe emodin	40
Alterporriol G and H (Atropisomers)	0
DRAQ5 dye	0
Emodin 8-glucoside	0
Lucidin	0
Lucidin omega-methyl ether	0
Obtusifolin	2
Obtusin	0
Purpurin 1-methyl ether	0
Questinol	0
Rhein	40
aklanonic acid +	0
alizarin +	18
alizarin complexone	0
anthraflavic acid	10
anthrarufin	0
aurantio-obtusin beta-D-glucoside	0
chrysazin +	74
chrysophanol +	31
dihydro-nogalonic acid methyl ester	0
gaboroquinone A	0
isoanthraflavin	0
knipholone +	0
methyl aklanonate	0
methyl nogalonate	0
mitoxantrone +	270
nogalonic acid +	0
nuclear fast red free acid	0
physcion +	15
questin	0
quinizarin	9
rubiadin	10
rubianthraquinone	0
scutianthraquinone A	0
scutianthraquinone B	0
scutianthraquinone C	0
variecolorquinone A	0
xanthopurpurin	0
Path 2
Term	Annotations
CHEBI ontology	26041
subatomic particle	26016
composite particle	26016
hadron	26016
baryon	26016
nucleon	26016
atomic nucleus	26016
atom	26016
main group element atom	25841
p-block element atom	25841
carbon group element atom	25441
carbon atom	25399
organic molecular entity	25399
heteroorganic entity	24773
organochalcogen compound	24384
organooxygen compound	24061
carbonyl compound	23569
ketone	19358
cyclic ketone	16849
quinone	9218
acenoquinone	8216
anthraquinone	533
hydroxyanthraquinones	522
dihydroxyanthraquinone	370
1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(3'-O-acetyl)-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3-dihydroxy-6-methoxy-2-methyl-9,10-anthraquinone	0
1,4-dihydroxy-2-methylanthraquinone	0
1,6-dihydroxy-2-methyl-9,10-anthraquinone	0
3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid	1
4'-O-demethylknipholone-4'-O-beta-D-glucopyranoside	0
Aloe emodin	40
Alterporriol G and H (Atropisomers)	0
DRAQ5 dye	0
Emodin 8-glucoside	0
Lucidin	0
Lucidin omega-methyl ether	0
Obtusifolin	2
Obtusin	0
Purpurin 1-methyl ether	0
Questinol	0
Rhein	40
aklanonic acid +	0
alizarin +	18
alizarin complexone	0
anthraflavic acid	10
anthrarufin	0
aurantio-obtusin beta-D-glucoside	0
chrysazin +	74
chrysophanol +	31
dihydro-nogalonic acid methyl ester	0
gaboroquinone A	0
isoanthraflavin	0
knipholone +	0
methyl aklanonate	0
methyl nogalonate	0
mitoxantrone +	270
nogalonic acid +	0
nuclear fast red free acid	0
physcion +	15
questin	0
quinizarin	9
rubiadin	10
rubianthraquinone	0
scutianthraquinone A	0
scutianthraquinone B	0
scutianthraquinone C	0
variecolorquinone A	0
xanthopurpurin	0

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