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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Clivoline
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Accession:CHEBI:3748 term browser browse the term
Definition:A ketone that has formula C21H27NO7.
Synonyms:related_synonym: Formula=C21H27NO7;   InChI=1S/C21H27NO7/c1-6-15-11-13(2)21(4,29-14(3)23)20(26)27-12-16-7-9-22(5)10-8-17(18(16)24)28-19(15)25/h6-7,11,13,17H,1,8-10,12H2,2-5H3/b15-11-,16-7-/t13-,17-,21+/m1/s1;   InChIKey=LIEIOJNANXUNDT-WIOQBUNOSA-N;   SMILES=C[C@@H]1\\C=C(C=C)/C(=O)O[C@@H]2CCN(C)C\\C=C(\\COC(=O)[C@@]1(C)OC(C)=O)C2=O
 xref: CAS:33979-15-6;   KEGG:C10282;   KNApSAcK:C00002082
 xref_mesh: MESH:C028677


show annotations for term's descendants           Sort by:
Clivoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions		 ISO clivorine results in decreased expression of BCL2L1 protein
EGF protein inhibits the reaction [clivorine results in decreased expression of BCL2L1 protein]		 CTD PMID:19437449 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO EGF protein inhibits the reaction [clivorine results in increased cleavage of CASP3 protein] CTD PMID:19437449 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO clivorine results in increased activity of CASP9 protein
EGF protein inhibits the reaction [clivorine results in increased activity of CASP9 protein]		 CTD PMID:19437449 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions		 ISO clivorine affects the localization of CYCS protein
EGF protein inhibits the reaction [clivorine affects the localization of CYCS protein]		 CTD PMID:19437449 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Egf epidermal growth factor multiple interactions
decreases response to substance		 ISO EGF protein inhibits the reaction [clivorine affects the localization of CYCS protein]; EGF protein inhibits the reaction [clivorine results in decreased expression of BCL2L1 protein]; EGF protein inhibits the reaction [clivorine results in increased activity of CASP9 protein]; EGF protein inhibits the reaction [clivorine results in increased cleavage of CASP3 protein]
EGF protein results in decreased susceptibility to clivorine		 CTD PMID:19437449 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA; pyrazolanthrone inhibits the reaction [[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA] CTD PMID:25881548 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases expression
multiple interactions		 ISO clivorine results in decreased expression of GCLM mRNA
pyrazolanthrone inhibits the reaction [Quercetin inhibits the reaction [clivorine results in decreased expression of GCLM mRNA]]; Quercetin inhibits the reaction [clivorine results in decreased expression of GCLM mRNA]		 CTD PMID:25881548 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO clivorine results in increased expression of KEAP1 mRNA CTD PMID:25881548 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      group 19768
        inorganic group 19361
          oxo group 18858
            organic oxo compound 18858
              carbonyl compound 18858
                ketone 17163
                  Clivoline 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbonyl compound 18858
                                    ketone 17163
                                      Clivoline 8
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