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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Clivoline
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Accession:CHEBI:3748 term browser browse the term
Definition:A ketone that has formula C21H27NO7.
Synonyms:related_synonym: Formula=C21H27NO7;   InChI=1S/C21H27NO7/c1-6-15-11-13(2)21(4,29-14(3)23)20(26)27-12-16-7-9-22(5)10-8-17(18(16)24)28-19(15)25/h6-7,11,13,17H,1,8-10,12H2,2-5H3/b15-11-,16-7-/t13-,17-,21+/m1/s1;   InChIKey=LIEIOJNANXUNDT-WIOQBUNOSA-N;   SMILES=C[C@@H]1\\C=C(C=C)/C(=O)O[C@@H]2CCN(C)C\\C=C(\\COC(=O)[C@@]1(C)OC(C)=O)C2=O
 xref: CAS:33979-15-6;   KEGG:C10282;   KNApSAcK:C00002082
 xref_mesh: MESH:C028677


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Clivoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO clivorine results in decreased expression of BCL2L1 protein
EGF protein inhibits the reaction [clivorine results in decreased expression of BCL2L1 protein]
CTD PMID:19437449 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO EGF protein inhibits the reaction [clivorine results in increased cleavage of CASP3 protein] CTD PMID:19437449 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO clivorine results in increased activity of CASP9 protein
EGF protein inhibits the reaction [clivorine results in increased activity of CASP9 protein]
CTD PMID:19437449 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO clivorine affects the localization of CYCS protein
EGF protein inhibits the reaction [clivorine affects the localization of CYCS protein]
CTD PMID:19437449 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Egf epidermal growth factor multiple interactions
decreases response to substance
ISO EGF protein inhibits the reaction [clivorine affects the localization of CYCS protein]; EGF protein inhibits the reaction [clivorine results in decreased expression of BCL2L1 protein]; EGF protein inhibits the reaction [clivorine results in increased activity of CASP9 protein]; EGF protein inhibits the reaction [clivorine results in increased cleavage of CASP3 protein]
EGF protein results in decreased susceptibility to clivorine
CTD PMID:19437449 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA; pyrazolanthrone inhibits the reaction [[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA] CTD PMID:25881548 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases expression
multiple interactions
ISO clivorine results in decreased expression of GCLM mRNA
pyrazolanthrone inhibits the reaction [Quercetin inhibits the reaction [clivorine results in decreased expression of GCLM mRNA]]; Quercetin inhibits the reaction [clivorine results in decreased expression of GCLM mRNA]
CTD PMID:25881548 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO clivorine results in increased expression of KEAP1 mRNA CTD PMID:25881548 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      group 19741
        inorganic group 19271
          oxo group 18675
            organic oxo compound 18675
              carbonyl compound 18675
                ketone 16923
                  Clivoline 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      ketone 16923
                                        Clivoline 8
paths to the root