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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:9,10-phenanthroquinone
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Accession:CHEBI:37454 term browser browse the term
Definition:A phenanthrene that has formula C14H8O2.
Synonyms:exact_synonym: phenanthrene-9,10-dione
 related_synonym: 9,10-Phenanthrenedione;   9,10-phenanthrenequinone;   Formula=C14H8O2;   InChI=1S/C14H8O2/c15-13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)14(13)16/h1-8H;   InChIKey=YYVYAPXYZVYDHN-UHFFFAOYSA-N;   Phenanthraquinone;   Phenanthrenequinone;   SMILES=O=C1C(=O)c2ccccc2-c2ccccc12
 alt_id: CHEBI:20817;   CHEBI:2330
 xref: Beilstein:608838;   CAS:84-11-7;   KEGG:C03243
 xref_mesh: MESH:C005399
 xref: UM-BBD_compID:c0511


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9,10-phenanthroquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions ISO AKR1A1 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone CTD PMID:21910479 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction
multiple interactions
ISO AKR1B1 protein results in increased reduction of 9,10-phenanthrenequinone
AKR1B1 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone
CTD PMID:10510318 PMID:21910479 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases metabolic processing
increases expression
ISO AKR1B10 protein results in increased metabolism of 9,10-phenanthrenequinone
9,10-phenanthrenequinone results in increased expression of AKR1B10 mRNA
CTD PMID:24813866 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 multiple interactions
increases reduction
ISO AKR1C4 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone
AKR1C4 protein results in increased reduction of 9,10-phenanthrenequinone
CTD PMID:21851338 PMID:21910479 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases metabolic processing
multiple interactions
increases reduction
ISO AKR1C2 protein results in increased metabolism of 9,10-phenanthrenequinone
AKR1C2 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone
AKR1C2 protein results in increased reduction of 9,10-phenanthrenequinone
CTD PMID:17950253 PMID:21851338 PMID:21910479 PMID:23261716 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases metabolic processing
increases expression
increases reduction
multiple interactions
ISO AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone
9,10-phenanthrenequinone results in increased expression of AKR1C3 protein
AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone
[AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone] which results in increased abundance of Superoxides; AKR1C3 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone; Indomethacin analog inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]; Indomethacin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]; N-(4-chlorobenzoyl)melatonin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]
CTD PMID:17950253 PMID:19442656 PMID:21851338 PMID:21910479 PMID:23261716 PMID:29108775 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 increases reduction
multiple interactions
affects reduction
ISO AKR7A2 protein results in increased reduction of 9,10-phenanthrenequinone
AKR7A2 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone
9,10-phenanthrenequinone affects the reduction of AKR7A5 protein
CTD PMID:10510318 PMID:12604212 PMID:21910479 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases reduction
multiple interactions
EXP
ISO
AKR7A3 protein results in increased reduction of 9,10-phenanthrenequinone
AKR7A3 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone
CTD PMID:19168568 PMID:21910479 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 9,10-phenanthrenequinone results in increased expression of BAX protein CTD PMID:29108775 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO 9,10-phenanthrenequinone results in increased expression of BBC3 protein CTD PMID:29108775 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 9,10-phenanthrenequinone results in decreased expression of BCL2 protein CTD PMID:29108775 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO 9,10-phenanthrenequinone results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in increased activity of CASP3 protein]
CTD PMID:25289770 PMID:29108775 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO 9,10-phenanthrenequinone results in increased activity of CASP9 protein
Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in increased activity of CASP9 protein]
CTD PMID:29108775 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein] CTD PMID:32493877 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions
increases metabolic processing
ISO [CBR1 protein co-treated with NADP] results in increased reduction of and affects the activity of 9,10-phenanthrenequinone; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 9,10-phenanthrenequinone] CTD PMID:21910479 PMID:23295225 PMID:29108775 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Cbr3 carbonyl reductase 3 increases metabolic processing ISO CBR3 protein results in increased metabolism of 9,10-phenanthrenequinone CTD PMID:19061875 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO 9,10-phenanthrenequinone results in increased expression of CCL11 protein CTD PMID:15669044 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions
increases metabolic processing
ISO 9,10-phenanthrenequinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; [CBR2 protein co-treated with NADP] results in increased reduction of and affects the activity of 9,10-phenanthrenequinone; [DCXR protein results in increased metabolism of 9,10-phenanthrenequinone] which results in increased chemical synthesis of Hydroxyl Radical CTD PMID:21910479 PMID:28595002 NCBI chr10:109,906,119...109,909,696
Ensembl chr10:109,906,815...109,909,715
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of 9,10-phenanthrenequinone CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of 9,10-phenanthrenequinone CTD PMID:24246760 NCBI chr 6:95,522,577...95,541,393
Ensembl chr 6:95,522,577...95,541,393
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of EGFR protein]; catalase-polyethylene glycol inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of EGFR protein] CTD PMID:32493877 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
ISO 1,10-phenanthroline inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of HMOX1 protein] CTD PMID:15629867 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il5 interleukin 5 increases expression ISO 9,10-phenanthrenequinone results in increased expression of IL5 protein CTD PMID:15669044 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO 9,10-phenanthrenequinone results in increased phosphorylation of MAPK1 protein
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of MAPK1 protein]; catalase-polyethylene glycol inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of MAPK1 protein]
CTD PMID:32493877 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of MAPK3 protein]; catalase-polyethylene glycol inhibits the reaction [9,10-phenanthrenequinone results in increased phosphorylation of MAPK3 protein] CTD PMID:32493877 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases secretion
increases expression
ISO 9,10-phenanthrenequinone results in increased secretion of MMP2 protein
9,10-phenanthrenequinone results in increased expression of MMP2 mRNA
CTD PMID:24813866 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO 9,10-phenanthrenequinone affects the localization of NFE2L2 protein CTD PMID:29108775 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
increases metabolic processing
increases response to substance
ISO [NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of 9,10-phenanthrenequinone; Acetylcysteine inhibits the reaction [NQO1 protein results in increased susceptibility to 9,10-phenanthrenequinone]; NQO1 protein promotes the reaction [Acetylcysteine results in decreased susceptibility to 9,10-phenanthrenequinone]
9,10-phenanthrenequinone results in increased expression of NQO1 protein
NQO1 protein results in increased metabolism of 9,10-phenanthrenequinone
CTD PMID:21910479 PMID:22925602 PMID:29108775 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO 9,10-phenanthrenequinone results in increased expression of PMAIP1 protein CTD PMID:29108775 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO [9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein; CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein] CTD PMID:32493877 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
ISO 1,10-phenanthroline inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of SOD1 protein] CTD PMID:15629867 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO 9,10-phenanthrenequinone binds to and results in decreased activity of TOP2A protein CTD PMID:22218491 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 affects localization ISO 9,10-phenanthrenequinone affects the localization of TP53 protein CTD PMID:29108775 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      biological role 19804
        xenobiotic 18437
          phenanthrenes 109
            9,10-phenanthroquinone 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                carbocyclic compound 18284
                                  carbopolycyclic compound 17043
                                    carbotricyclic compound 1052
                                      phenanthrenes 109
                                        9,10-phenanthroquinone 33
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