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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:crown compound
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Accession:CHEBI:37409 term browser browse the term
Definition:A macrocyclic polydentate compound, usually uncharged, in which three or more coordinating ring atoms are or may become suitably close for easy formation of chelate complexes with metal ions or other cationic species.
Synonyms:exact_synonym: crown;   crown compounds
 related_synonym: corona;   coronand;   coronands;   couronne



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1,4,7-triazonane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases expression ISO 1,4,7-triazacyclononane results in decreased expression of CAT protein CTD PMID:32869927 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO 1,4,7-triazacyclononane results in increased expression of GPX1 protein CTD PMID:32869927 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO 1,4,7-triazacyclononane results in increased expression of NFE2L2 protein CTD PMID:32869927 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
plerixafor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO
plerixafor inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]
plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]
CTD PMID:18660423 PMID:29510123 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO plerixafor inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]; plerixafor inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]; plerixafor inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]
plerixafor increases expression of CDH1 protein in lymph node and prostate epithelium
CTD
RGD
PMID:28844962 PMID:30537000 RGD:152025215 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO plerixafor decreases expression of CDH2 protein in lymph node and prostate epithelium RGD PMID:30537000 RGD:152025215 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
decreases expression
ISO plerixafor inhibits the reaction [CXCL12 protein affects the localization of CXCR4 protein]; plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]
plerixafor results in decreased expression of CXCL12 mRNA
CTD PMID:12220670 PMID:18660423 PMID:24157575 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases activity
decreases phosphorylation
decreases expression
multiple interactions
ISO
EXP
plerixafor results in decreased activity of CXCR4 protein
plerixafor decreases phosphorylation of CXCR4 protein in lymph node and prostate epithelium
plerixafor decreases expression of CXCR4 mRNA and protein in lymph node and prostate epithelium
Plerixafor decreases expression of CXCR4 protein in liver
plerixafor binds to and results in decreased activity of CXCR4 protein; plerixafor inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]; plerixafor inhibits the reaction [CXCL12 protein affects the localization of CXCR4 protein]; plerixafor inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]; plerixafor inhibits the reaction [Triclosan results in increased expression of CXCR4 protein]
plerixafor results in decreased expression of CXCR4 protein
CTD
RGD
PMID:12220670 PMID:17121897 PMID:28844962 PMID:30537000 PMID:30537000 More... RGD:152025215, RGD:152025215, RGD:151893463 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein] CTD PMID:18660423 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO plerixafor inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]; plerixafor inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]; plerixafor inhibits the reaction [Triclosan results in increased expression of SNAI2 protein] CTD PMID:28844962 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Particulate Matter results in decreased susceptibility to [VEGFA protein modified form co-treated with plerixafor]
plerixafor inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]
CTD PMID:22418586 PMID:25815440 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin decreases expression ISO plerixafor decreases expression on VIM protein in lymph node and prostate epithelium RGD PMID:30537000 RGD:152025215 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19863
    chemical entity 19861
      atom 19861
        nonmetal atom 19790
          carbon atom 19744
            organic molecular entity 19744
              heteroorganic entity 19498
                organic heterocyclic compound 18878
                  crown compound 12
                    1,10-dioxa-4,7,13,16-tetraphosphacyclooctadecane 0
                    3'-O-phosphono-ADP-[(3R)-27-amino-3-hydroxy-2,2-dimethyl-4,8,14-trioxo-12-thia-5,9,15,19,24-pentaazaheptacosane] 0
                    corynebactin 0
                    crown amine + 12
                    crown ether + 0
                    crown thioether + 0
                    enterobactin + 0
                    sodium-binding benzofuran isophthalate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19863
    subatomic particle 19861
      composite particle 19861
        hadron 19861
          baryon 19861
            nucleon 19861
              atomic nucleus 19861
                atom 19861
                  main group element atom 19807
                    p-block element atom 19807
                      carbon group element atom 19748
                        carbon atom 19744
                          organic molecular entity 19744
                            organic molecule 19695
                              organic cyclic compound 19506
                                organic heterocyclic compound 18878
                                  crown compound 12
                                    1,10-dioxa-4,7,13,16-tetraphosphacyclooctadecane 0
                                    3'-O-phosphono-ADP-[(3R)-27-amino-3-hydroxy-2,2-dimethyl-4,8,14-trioxo-12-thia-5,9,15,19,24-pentaazaheptacosane] 0
                                    corynebactin 0
                                    crown amine + 12
                                    crown ether + 0
                                    crown thioether + 0
                                    enterobactin + 0
                                    sodium-binding benzofuran isophthalate 0
paths to the root