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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pnictogen halide
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Accession:CHEBI:37380 term browser browse the term

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arsenic trichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
increases activity		 ISO Acetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein]; AKT1 mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]; arsenic trichloride promotes the reaction [AKT1 protein binds to FLNA protein modified form]; arsenic trichloride promotes the reaction [AKT1 protein modified form binds to FLNA protein modified form]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein]
MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein]; MAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein]		 CTD PMID:22696236, PMID:25944616 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [arsenic trichloride results in increased activity of CTNNB1 protein]; CAT protein inhibits the reaction [arsenic trichloride results in increased expression of CTNNB1 protein] CTD PMID:21854796 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions
increases activity		 ISO arsenic trichloride results in increased expression of CTNNB1 protein
CAT protein inhibits the reaction [arsenic trichloride results in increased activity of CTNNB1 protein]; CAT protein inhibits the reaction [arsenic trichloride results in increased expression of CTNNB1 protein]		 CTD PMID:21854796 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO IKBKB affects the reaction [arsenic trichloride results in increased expression of DDIT3 mRNA] CTD PMID:16283526 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions ISO arsenic trichloride promotes the reaction [ELAVL1 protein binds to GADD45A mRNA] CTD PMID:16421274 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432 		JBrowse link
G Flna filamin A multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]; AKT1 mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]; arsenic trichloride promotes the reaction [AKT1 protein binds to FLNA protein modified form]; arsenic trichloride promotes the reaction [AKT1 protein modified form binds to FLNA protein modified form]; wortmannin inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein] CTD PMID:25944616 NCBI chr  X:156,460,785...156,487,245
Ensembl chr  X:156,463,953...156,487,245 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression
affects response to substance		 ISO arsenic trichloride promotes the reaction [ELAVL1 protein binds to GADD45A mRNA]; arsenic trichloride promotes the reaction [NCL protein binds to GADD45A mRNA]; arsenic trichloride results in increased stability of and results in increased expression of GADD45A mRNA; GPX1 protein inhibits the reaction [arsenic trichloride results in increased expression of GADD45A protein]; Hydrogen Peroxide promotes the reaction [arsenic trichloride results in increased expression of GADD45A protein]
arsenic trichloride results in increased expression of GADD45A mRNA; arsenic trichloride results in increased expression of GADD45A protein
IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45A protein]
GADD45A protein affects the susceptibility to arsenic trichloride		 CTD PMID:16283526, PMID:16421274, PMID:16814109, PMID:18942077 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression
multiple interactions		 ISO arsenic trichloride results in increased expression of GADD45B mRNA
IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45B mRNA]		 CTD PMID:16283526 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression
multiple interactions		 ISO arsenic trichloride results in increased expression of GADD45G mRNA
IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45G mRNA]		 CTD PMID:16283526 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO GPX1 protein inhibits the reaction [arsenic trichloride results in increased expression of GADD45A protein] CTD PMID:16814109 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO arsenic trichloride results in increased expression of HMOX1 mRNA CTD PMID:19276070 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO IKBKB affects the reaction [arsenic trichloride results in increased expression of DDIT3 mRNA]; IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45A protein]; IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45B mRNA]; IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45G mRNA] CTD PMID:16283526 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815 		JBrowse link
G Il2 interleukin 2 decreases secretion ISO arsenic trichloride results in decreased secretion of IL2 protein CTD PMID:27714827 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il6 interleukin 6 increases secretion ISO arsenic trichloride results in increased secretion of IL6 protein CTD PMID:22696236 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 ISO pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK8 protein]
MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein]; MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]		 CTD PMID:22696236, PMID:24434654 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 ISO MAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein]; MAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]
arsenic trichloride results in increased phosphorylation of MAPK9 protein
MAPK9 mutant form inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 protein]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein]; stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein]		 CTD PMID:22696236, PMID:24434654 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mir106a microRNA 106a increases expression ISO arsenic trichloride results in increased expression of MIR106A CTD PMID:21750348 NCBI chr  X:140,117,891...140,117,968
Ensembl chr  X:140,117,891...140,117,968 		JBrowse link
G Mir17 microRNA 17 increases expression ISO arsenic trichloride results in increased expression of MIR17 CTD PMID:21750348 NCBI chr15:100,179,879...100,179,962
Ensembl chr15:100,179,879...100,179,962 		JBrowse link
G Mir190 microRNA 190 increases expression
multiple interactions		 ISO arsenic trichloride results in increased expression of MIR190A
[arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to PHLPP1 3' UTR] which results in decreased expression of PHLPP1 protein]; [arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to TP53INP1 3' UTR] which results in decreased expression of TP53INP1 protein]; [arsenic trichloride results in increased expression of MIR190A] which results in decreased expression of PHLPP1 protein		 CTD PMID:21750348 NCBI chr 8:73,030,047...73,030,131
Ensembl chr 8:73,030,047...73,030,131 		JBrowse link
G Mir19a microRNA 19a increases expression ISO arsenic trichloride results in increased expression of MIR19A CTD PMID:21750348 NCBI chr15:100,180,162...100,180,243
Ensembl chr15:100,180,162...100,180,243 		JBrowse link
G Mir1b microRNA 1b increases expression ISO arsenic trichloride results in increased expression of MIR1-1 CTD PMID:21750348 NCBI chr 3:175,769,716...175,769,800
Ensembl chr 3:175,769,716...175,769,800 		JBrowse link
G Mir20a microRNA 20a increases expression ISO arsenic trichloride results in increased expression of MIR20A CTD PMID:21750348 NCBI chr15:100,180,334...100,180,418
Ensembl chr15:100,180,334...100,180,418 		JBrowse link
G Mir21 microRNA 21 multiple interactions
affects expression		 ISO MIR21 mRNA affects the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; pyrazolanthrone affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA]; stattic affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA] CTD PMID:24434654 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301 		JBrowse link
G Mir92a1 microRNA 92a-1 increases expression ISO arsenic trichloride results in increased expression of MIR92A1 CTD PMID:21750348 NCBI chr15:100,180,586...100,180,663
Ensembl chr15:100,180,586...100,180,663 		JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression		 ISO arsenic trichloride promotes the reaction [MTF1 protein binds to MT1 protein]; Cycloheximide promotes the reaction [arsenic trichloride results in increased expression of MT1 mRNA]; MTF1 protein affects the reaction [arsenic trichloride results in increased expression of MT1 mRNA]; MTF1 protein affects the reaction [Cycloheximide promotes the reaction [arsenic trichloride results in increased expression of MT1 mRNA]] CTD PMID:19276070 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions
decreases response to substance
affects response to substance		 ISO arsenic trichloride promotes the reaction [MTF1 protein binds to MT1 protein]; MTF1 protein affects the reaction [arsenic trichloride results in increased expression of MT1 mRNA]; MTF1 protein affects the reaction [Cycloheximide promotes the reaction [arsenic trichloride results in increased expression of MT1 mRNA]]
MTF1 protein results in decreased susceptibility to arsenic trichloride
MTF1 protein affects the susceptibility to arsenic trichloride		 CTD PMID:19276070 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO arsenic trichloride results in increased expression of MYC mRNA; arsenic trichloride results in increased expression of MYC protein CTD PMID:16283526 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression ISO arsenic trichloride results in increased expression of NCF1 protein CTD PMID:21854796 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 increases expression ISO arsenic trichloride results in increased expression of NCF2 protein CTD PMID:21854796 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576 		JBrowse link
G Ncl nucleolin affects localization
multiple interactions		 ISO arsenic trichloride affects the localization of NCL protein
arsenic trichloride promotes the reaction [NCL protein binds to GADD45A mRNA]		 CTD PMID:16421274 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 protein affects the reaction [arsenic trichloride results in increased expression of NQO1 mRNA] CTD PMID:19276070 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO arsenic trichloride results in increased expression of NQO1 mRNA
NFE2L2 protein affects the reaction [arsenic trichloride results in increased expression of NQO1 mRNA]		 CTD PMID:19276070 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 multiple interactions ISO [arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to PHLPP1 3' UTR] which results in decreased expression of PHLPP1 protein]; [arsenic trichloride results in increased expression of MIR190A] which results in decreased expression of PHLPP1 protein CTD PMID:21750348 NCBI chr13:26,145,989...26,394,505
Ensembl chr13:26,172,243...26,394,505 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation ISO arsenic trichloride results in increased phosphorylation of RB1 protein CTD PMID:16283526 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Riox2 ribosomal oxygenase 2 multiple interactions
increases phosphorylation
increases expression		 ISO MAPK9 mutant form inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 protein]; MIR21 mRNA affects the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein]; STAT3 mutant form inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 protein]; stattic inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein]; wortmannin inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]
arsenic trichloride results in increased expression of RIOX2 mRNA; arsenic trichloride results in increased expression of RIOX2 protein		 CTD PMID:24434654 NCBI chr11:43,006,190...43,028,722
Ensembl chr11:43,006,757...43,022,565 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
affects phosphorylation
multiple interactions		 ISO arsenic trichloride results in increased phosphorylation of STAT3 protein
arsenic trichloride affects the phosphorylation of STAT3 protein
MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]; MAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]
pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]; STAT3 mutant form inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 protein]; STAT3 mutant form inhibits the reaction [arsenic trichloride results in increased expression of VEGFA protein]		 CTD PMID:22696236, PMID:24434654 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tln2 talin 2 increases expression ISO arsenic trichloride results in increased expression of TLN2 mRNA; arsenic trichloride results in increased expression of TLN2 protein CTD PMID:21750348 NCBI chr 8:73,009,980...73,441,536
Ensembl chr 8:73,014,137...73,194,837 		JBrowse link
G Tp53 tumor protein p53 increases phosphorylation ISO arsenic trichloride results in increased phosphorylation of TRP53 protein CTD PMID:16283526 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions ISO [arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to TP53INP1 3' UTR] which results in decreased expression of TP53INP1 protein] CTD PMID:21750348 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 ISO STAT3 mutant form inhibits the reaction [arsenic trichloride results in increased expression of VEGFA protein] CTD PMID:22696236 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      molecular entity 19808
        main group molecular entity 19696
          p-block molecular entity 19696
            pnictogen molecular entity 18672
              pnictogen halide 40
                arsenic pentafluoride 0
                arsenic trichloride 40
                bismuth pentafluoride 0
                nitrogen halide + 0
                phosphorus halide + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      p-block molecular entity 19696
                        pnictogen molecular entity 18672
                          pnictogen halide 40
                            arsenic pentafluoride 0
                            arsenic trichloride 40
                            bismuth pentafluoride 0
                            nitrogen halide + 0
                            phosphorus halide + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.