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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases activity increases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein]; AKT1 mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]; arsenic trichloride promotes the reaction [AKT1 protein binds to FLNA protein modified form]; arsenic trichloride promotes the reaction [AKT1 protein modified form binds to FLNA protein modified form]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein] MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein]; MAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:22696236 PMID:25944616 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Cat |
catalase |
multiple interactions |
ISO |
CAT protein inhibits the reaction [arsenic trichloride results in increased activity of CTNNB1 protein]; CAT protein inhibits the reaction [arsenic trichloride results in increased expression of CTNNB1 protein] |
CTD |
PMID:21854796 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ctnnb1 |
catenin beta 1 |
increases expression increases activity multiple interactions |
ISO |
arsenic trichloride results in increased expression of CTNNB1 protein arsenic trichloride results in increased activity of CTNNB1 protein CAT protein inhibits the reaction [arsenic trichloride results in increased activity of CTNNB1 protein]; CAT protein inhibits the reaction [arsenic trichloride results in increased expression of CTNNB1 protein] |
CTD |
PMID:21854796 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
IKBKB affects the reaction [arsenic trichloride results in increased expression of DDIT3 mRNA] |
CTD |
PMID:16283526 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Elavl1 |
ELAV like RNA binding protein 1 |
multiple interactions |
ISO |
arsenic trichloride promotes the reaction [ELAVL1 protein binds to GADD45A mRNA] |
CTD |
PMID:16421274 |
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NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
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G |
Flna |
filamin A |
multiple interactions increases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]; AKT1 mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]; arsenic trichloride promotes the reaction [AKT1 protein binds to FLNA protein modified form]; arsenic trichloride promotes the reaction [AKT1 protein modified form binds to FLNA protein modified form]; wortmannin inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein] |
CTD |
PMID:25944616 |
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NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
multiple interactions affects response to substance increases expression |
ISO |
arsenic trichloride promotes the reaction [ELAVL1 protein binds to GADD45A mRNA]; arsenic trichloride promotes the reaction [NCL protein binds to GADD45A mRNA]; arsenic trichloride results in increased stability of and results in increased expression of GADD45A mRNA; GPX1 protein inhibits the reaction [arsenic trichloride results in increased expression of GADD45A protein]; Hydrogen Peroxide promotes the reaction [arsenic trichloride results in increased expression of GADD45A protein] GADD45A protein affects the susceptibility to arsenic trichloride IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45A protein] arsenic trichloride results in increased expression of GADD45A mRNA; arsenic trichloride results in increased expression of GADD45A protein |
CTD |
PMID:16283526 PMID:16421274 PMID:16814109 PMID:18942077 |
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NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gadd45b |
growth arrest and DNA-damage-inducible, beta |
increases expression multiple interactions |
ISO |
arsenic trichloride results in increased expression of GADD45B mRNA IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45B mRNA] |
CTD |
PMID:16283526 |
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NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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G |
Gadd45g |
growth arrest and DNA-damage-inducible, gamma |
increases expression multiple interactions |
ISO |
arsenic trichloride results in increased expression of GADD45G mRNA IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45G mRNA] |
CTD |
PMID:16283526 |
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NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO |
GPX1 protein inhibits the reaction [arsenic trichloride results in increased expression of GADD45A protein] |
CTD |
PMID:16814109 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
arsenic trichloride results in increased expression of HMOX1 mRNA |
CTD |
PMID:19276070 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
IKBKB affects the reaction [arsenic trichloride results in increased expression of DDIT3 mRNA]; IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45A protein]; IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45B mRNA]; IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45G mRNA] |
CTD |
PMID:16283526 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il2 |
interleukin 2 |
decreases secretion |
ISO |
arsenic trichloride results in decreased secretion of IL2 protein |
CTD |
PMID:27714827 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il6 |
interleukin 6 |
increases secretion |
ISO |
arsenic trichloride results in increased secretion of IL6 protein |
CTD |
PMID:22696236 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation |
ISO |
pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK8 protein] MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein]; MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:22696236 PMID:24434654 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions increases phosphorylation |
ISO |
MAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein]; MAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein] MAPK9 mutant form inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 protein]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein]; stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:22696236 PMID:24434654 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mir106a |
microRNA 106a |
increases expression |
ISO |
arsenic trichloride results in increased expression of MIR106A |
CTD |
PMID:21750348 |
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NCBI chr X:132,422,584...132,422,661
Ensembl chr X:132,422,584...132,422,661
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G |
Mir17 |
microRNA 17 |
increases expression |
ISO |
arsenic trichloride results in increased expression of MIR17 |
CTD |
PMID:21750348 |
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NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712
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G |
Mir190 |
microRNA 190 |
increases expression multiple interactions |
ISO |
arsenic trichloride results in increased expression of MIR190A [arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to PHLPP1 3' UTR] which results in decreased expression of PHLPP1 protein]; [arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to TP53INP1 3' UTR] which results in decreased expression of TP53INP1 protein]; [arsenic trichloride results in increased expression of MIR190A] which results in decreased expression of PHLPP1 protein |
CTD |
PMID:21750348 |
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NCBI chr 8:67,850,987...67,851,071
Ensembl chr 8:67,850,987...67,851,071
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G |
Mir19a |
microRNA 19a |
increases expression |
ISO |
arsenic trichloride results in increased expression of MIR19A |
CTD |
PMID:21750348 |
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NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993
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G |
Mir1b |
microRNA 1b |
increases expression |
ISO |
arsenic trichloride results in increased expression of MIR1-1 |
CTD |
PMID:21750348 |
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NCBI chr 3:167,487,117...167,487,201
Ensembl chr 3:167,487,117...167,487,201
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G |
Mir20a |
microRNA 20a |
increases expression |
ISO |
arsenic trichloride results in increased expression of MIR20A |
CTD |
PMID:21750348 |
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NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168
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G |
Mir21 |
microRNA 21 |
multiple interactions affects expression |
ISO |
MIR21 mRNA affects the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; pyrazolanthrone affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA]; stattic affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA] |
CTD |
PMID:24434654 |
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NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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G |
Mir92a1 |
microRNA 92a-1 |
increases expression |
ISO |
arsenic trichloride results in increased expression of MIR92A1 |
CTD |
PMID:21750348 |
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NCBI chr15:92,181,336...92,181,413
Ensembl chr15:92,181,336...92,181,413
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G |
Mtf1 |
metal-regulatory transcription factor 1 |
multiple interactions affects response to substance decreases response to substance |
ISO |
arsenic trichloride promotes the reaction [MTF1 protein binds to MT1 protein]; MTF1 protein affects the reaction [arsenic trichloride results in increased expression of MT1 mRNA]; MTF1 protein affects the reaction [Cycloheximide promotes the reaction [arsenic trichloride results in increased expression of MT1 mRNA]] MTF1 protein affects the susceptibility to arsenic trichloride MTF1 protein results in decreased susceptibility to arsenic trichloride |
CTD |
PMID:19276070 |
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NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
ISO |
arsenic trichloride results in increased expression of MYC mRNA; arsenic trichloride results in increased expression of MYC protein |
CTD |
PMID:16283526 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
increases expression |
ISO |
arsenic trichloride results in increased expression of NCF1 protein |
CTD |
PMID:21854796 |
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NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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G |
Ncf2 |
neutrophil cytosolic factor 2 |
increases expression |
ISO |
arsenic trichloride results in increased expression of NCF2 protein |
CTD |
PMID:21854796 |
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NCBI chr13:64,955,502...64,986,289
Ensembl chr13:64,955,503...64,986,277
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G |
Ncl |
nucleolin |
affects localization multiple interactions |
ISO |
arsenic trichloride affects the localization of NCL protein arsenic trichloride promotes the reaction [NCL protein binds to GADD45A mRNA] |
CTD |
PMID:16421274 |
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NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
NFE2L2 protein affects the reaction [arsenic trichloride results in increased expression of NQO1 mRNA] |
CTD |
PMID:19276070 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO |
arsenic trichloride results in increased expression of NQO1 mRNA NFE2L2 protein affects the reaction [arsenic trichloride results in increased expression of NQO1 mRNA] |
CTD |
PMID:19276070 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Phlpp1 |
PH domain and leucine rich repeat protein phosphatase 1 |
multiple interactions |
ISO |
[arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to PHLPP1 3' UTR] which results in decreased expression of PHLPP1 protein]; [arsenic trichloride results in increased expression of MIR190A] which results in decreased expression of PHLPP1 protein |
CTD |
PMID:21750348 |
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NCBI chr13:22,308,532...22,530,978
Ensembl chr13:22,308,548...22,530,977
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G |
Rb1 |
RB transcriptional corepressor 1 |
increases phosphorylation |
ISO |
arsenic trichloride results in increased phosphorylation of RB1 protein |
CTD |
PMID:16283526 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Riox2 |
ribosomal oxygenase 2 |
multiple interactions increases expression increases phosphorylation |
ISO |
MAPK9 mutant form inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 protein]; MIR21 mRNA affects the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein]; STAT3 mutant form inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 protein]; stattic inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein]; wortmannin inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA] arsenic trichloride results in increased expression of RIOX2 mRNA; arsenic trichloride results in increased expression of RIOX2 protein |
CTD |
PMID:24434654 |
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NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574
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G |
Stat3 |
signal transducer and activator of transcription 3 |
increases phosphorylation multiple interactions affects phosphorylation |
ISO |
arsenic trichloride results in increased phosphorylation of STAT3 protein pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]; STAT3 mutant form inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 protein]; STAT3 mutant form inhibits the reaction [arsenic trichloride results in increased expression of VEGFA protein] MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]; MAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein] arsenic trichloride affects the phosphorylation of STAT3 protein |
CTD |
PMID:22696236 PMID:24434654 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tln2 |
talin 2 |
increases expression |
ISO |
arsenic trichloride results in increased expression of TLN2 mRNA; arsenic trichloride results in increased expression of TLN2 protein |
CTD |
PMID:21750348 |
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NCBI chr 8:67,830,920...68,252,223
Ensembl chr 8:67,834,326...68,252,219
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G |
Tp53 |
tumor protein p53 |
increases phosphorylation |
ISO |
arsenic trichloride results in increased phosphorylation of TRP53 protein |
CTD |
PMID:16283526 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tp53inp1 |
tumor protein p53 inducible nuclear protein 1 |
multiple interactions |
ISO |
[arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to TP53INP1 3' UTR] which results in decreased expression of TP53INP1 protein] |
CTD |
PMID:21750348 |
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NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions increases expression |
ISO |
STAT3 mutant form inhibits the reaction [arsenic trichloride results in increased expression of VEGFA protein] |
CTD |
PMID:22696236 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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