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ONTOLOGY REPORT - ANNOTATIONS


Term:clemastine
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Accession:CHEBI:3738 term browser browse the term
Definition:2-[(2R)-1-Methylpyrrolidin-2-yl]ethanol in which the hydrogen of the hydroxy group is substituted by a 1-(4-chlorophenyl)-1-phenylethyl group (R configuration). An antihistamine with antimuscarinic and moderate sedative properties, it is used as its fumarate salt for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin conditions.
Synonyms:exact_synonym: (2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine
 related_synonym: (+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine;   Formula=C21H26ClNO;   InChI=1S/C21H26ClNO/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3/t20-,21-/m1/s1;   InChIKey=YNNUSGIPVFPVBX-NHCUHLMSSA-N;   SMILES=[H][C@@]1(CCCN1C)CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1;   clemastina;   clemastinum
 alt_id: CHEBI:569763
 xref: Beilstein:6486432 "Beilstein";   CAS:15686-51-8 "ChemIDplus";   CAS:15686-51-8 "KEGG COMPOUND";   CAS:15686-51-8 "NIST Chemistry WebBook";   DrugBank:DB00283;   Drug_Central:671 "DrugCentral";   KEGG:C06913;   KEGG:D03535;   LINCS:LSM-2655
 xref_mesh: MESH:D002974
 xref: PMID:18788725 "ChEMBL";   Patent:GB942152;   Wikipedia:Clemastine


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clemastine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Hrh1 histamine receptor H 1 JBrowse link 4 146,374,596 146,458,148 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        pharmaceutical 19081
          drug 19081
            anti-allergic agent 3773
              clemastine 3
                clemastine fumarate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    main group molecular entity 19531
                      s-block molecular entity 19314
                        hydrogen molecular entity 19303
                          hydrides 18231
                            inorganic hydride 17095
                              pnictogen hydride 17053
                                nitrogen hydride 16874
                                  azane 16551
                                    ammonia 16548
                                      organic amino compound 16547
                                        tertiary amino compound 8517
                                          N-alkylpyrrolidine 1091
                                            clemastine 3
                                              clemastine fumarate 0
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