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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tropane alkaloid
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Accession:CHEBI:37332 term browser browse the term
Synonyms:related_synonym: tropane alkaloids
 alt_id: CHEBI:27154;   CHEBI:27155


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cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases expression
multiple interactions
EXP Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]
CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 879
    role 859
      biological role 859
        biochemical role 728
          metabolite 716
            alkaloid 46
              tropane alkaloid 1
                (2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                (2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                (2S)-3-hydroxy-2-phenylpropanoic acid [(5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                (6R)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-one 0
                1-(1-adamantyl)-3-[8-[[1-(2-furanylmethyl)-5-tetrazolyl]methyl]-8-azabicyclo[3.2.1]octan-3-yl]urea 0
                18-demethylgardfloramine 0
                18-demethylgardneramine 0
                19(E)-11-Methoxy-9,18-didemethoxygardneramine 0
                19(E)-18-Demethoxygardfloramine-N(4)-oxide 0
                19(E)-18-demethoxygardfloramine 0
                19(E)-18-demethoxygardneramine 0
                19(E)-9,18-Didemethoxygardneramine 0
                2-(4-bromophenyl)propanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester 0
                2-hydroxy-2-phenylacetic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                2-hydroxy-2-phenylacetic acid [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                2-hydroxy-2-phenylacetic acid [(5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                3-hydroxy-2-phenylpropanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester 0
                3-hydroxy-2-phenylpropanoic acid (8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl) ester 0
                3-hydroxy-2-phenylpropanoic acid [(1R,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                3-hydroxy-2-phenylpropanoic acid [(5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                3-hydroxy-2-phenylpropanoic acid [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                3beta,6beta-Dihydroxynortropane 0
                4,4-difluoro-N-[(1S)-3-[3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]-1-cyclohexanecarboxamide 0
                9-Demethoxy-18-demethylgardneramine 0
                Acetylpseudotropine 0
                Anatoxin a 0
                Brugine 0
                Calystegine C1 0
                Gardfloramine-N(4)-oxide 0
                Knightinol 0
                Littorine 0
                Meteloidine 0
                Nor-psi-tropine 0
                O-hydroxy(phenyl)phosphinoyl ecgonine methyl ester 0
                Physoperuvine 0
                Pseudoecgonine 0
                Schizanthine N 0
                Schizanthine O 0
                Schizanthine P 0
                Scopoline 0
                Tigloidine 0
                Valeroidine 0
                [(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate 0
                [(1S,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate 0
                atropine oxyde 0
                butylscopolamine + 0
                cocaine 1
                cocaine(1+) + 0
                ecgonine + 0
                ecgonine benzoate 0
                ecgonine methyl ester + 0
                ecgonone methyl ester 0
                gardfloramine 0
                gardneramine 0
                gardneramine-N(4)-oxide 0
                ipratropium + 0
                itasetron 0
                methylatropine 0
                pseudotropine + 0
                scopolamine + 0
                tematropium methylsulfate 0
                tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate + 0
                tropane + 0
                tropanyl 3,5-dimethylbenzoate 0
                tropine + 0
                tropinone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 879
    subatomic particle 864
      composite particle 864
        hadron 864
          baryon 864
            nucleon 864
              atomic nucleus 864
                atom 864
                  main group element atom 854
                    p-block element atom 851
                      carbon group element atom 827
                        carbon atom 826
                          organic molecular entity 826
                            organic molecule 738
                              organic cyclic compound 647
                                organic heterocyclic compound 362
                                  organic heteropolycyclic compound 251
                                    organic heterobicyclic compound 99
                                      azabicycloalkane 1
                                        tropane alkaloid 1
                                          (2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                                          (2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                                          (2S)-3-hydroxy-2-phenylpropanoic acid [(5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                                          (6R)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-one 0
                                          1-(1-adamantyl)-3-[8-[[1-(2-furanylmethyl)-5-tetrazolyl]methyl]-8-azabicyclo[3.2.1]octan-3-yl]urea 0
                                          18-demethylgardfloramine 0
                                          18-demethylgardneramine 0
                                          19(E)-11-Methoxy-9,18-didemethoxygardneramine 0
                                          19(E)-18-Demethoxygardfloramine-N(4)-oxide 0
                                          19(E)-18-demethoxygardfloramine 0
                                          19(E)-18-demethoxygardneramine 0
                                          19(E)-9,18-Didemethoxygardneramine 0
                                          2-(4-bromophenyl)propanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester 0
                                          2-hydroxy-2-phenylacetic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                                          2-hydroxy-2-phenylacetic acid [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                                          2-hydroxy-2-phenylacetic acid [(5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                                          3-hydroxy-2-phenylpropanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester 0
                                          3-hydroxy-2-phenylpropanoic acid (8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl) ester 0
                                          3-hydroxy-2-phenylpropanoic acid [(1R,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                                          3-hydroxy-2-phenylpropanoic acid [(5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                                          3-hydroxy-2-phenylpropanoic acid [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                                          3beta,6beta-Dihydroxynortropane 0
                                          4,4-difluoro-N-[(1S)-3-[3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]-1-cyclohexanecarboxamide 0
                                          9-Demethoxy-18-demethylgardneramine 0
                                          Acetylpseudotropine 0
                                          Anatoxin a 0
                                          Brugine 0
                                          Calystegine C1 0
                                          Gardfloramine-N(4)-oxide 0
                                          Knightinol 0
                                          Littorine 0
                                          Meteloidine 0
                                          Nor-psi-tropine 0
                                          O-hydroxy(phenyl)phosphinoyl ecgonine methyl ester 0
                                          Physoperuvine 0
                                          Pseudoecgonine 0
                                          Schizanthine N 0
                                          Schizanthine O 0
                                          Schizanthine P 0
                                          Scopoline 0
                                          Tigloidine 0
                                          Valeroidine 0
                                          [(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate 0
                                          [(1S,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate 0
                                          atropine oxyde 0
                                          butylscopolamine + 0
                                          cocaine 1
                                          cocaine(1+) + 0
                                          ecgonine + 0
                                          ecgonine benzoate 0
                                          ecgonine methyl ester + 0
                                          ecgonone methyl ester 0
                                          gardfloramine 0
                                          gardneramine 0
                                          gardneramine-N(4)-oxide 0
                                          ipratropium + 0
                                          itasetron 0
                                          methylatropine 0
                                          pseudotropine + 0
                                          scopolamine + 0
                                          tematropium methylsulfate 0
                                          tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate + 0
                                          tropane + 0
                                          tropanyl 3,5-dimethylbenzoate 0
                                          tropine + 0
                                          tropinone 0
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