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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tropane alkaloid
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Accession:CHEBI:37332 term browser browse the term
Synonyms:related_synonym: tropane alkaloids
 alt_id: CHEBI:27154;   CHEBI:27155


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cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases expression
multiple interactions		 EXP Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]		 CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      biological role 5016
        biochemical role 4938
          metabolite 4926
            alkaloid 74
              tropane alkaloid 1
                (2R,3S)-3-Hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid 0
                (2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                (2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                (2S)-3-hydroxy-2-phenylpropanoic acid [(5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                (6R)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-one 0
                1-(1-adamantyl)-3-[8-[[1-(2-furanylmethyl)-5-tetrazolyl]methyl]-8-azabicyclo[3.2.1]octan-3-yl]urea 0
                18-demethylgardfloramine 0
                18-demethylgardneramine 0
                19(E)-11-Methoxy-9,18-didemethoxygardneramine 0
                19(E)-18-Demethoxygardfloramine-N(4)-oxide 0
                19(E)-18-demethoxygardfloramine 0
                19(E)-18-demethoxygardneramine 0
                19(E)-9,18-Didemethoxygardneramine 0
                2-(4-bromophenyl)propanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester 0
                2-hydroxy-2-phenylacetic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                2-hydroxy-2-phenylacetic acid [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                2-hydroxy-2-phenylacetic acid [(5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                3,6-Ditigloyloxytropan-7-ol 0
                3-hydroxy-2-phenylpropanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester 0
                3-hydroxy-2-phenylpropanoic acid (8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl) ester 0
                3-hydroxy-2-phenylpropanoic acid [(1R,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                3-hydroxy-2-phenylpropanoic acid [(5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                3-hydroxy-2-phenylpropanoic acid [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                3alpha-Tigloyloxytropane N-oxide 0
                3beta,6beta-Dihydroxynortropane 0
                4,4-Difluoro-N-[(1S)-3-[(1R,5S)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboximidic acid 0
                4,4-difluoro-N-[(1S)-3-[3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]-1-cyclohexanecarboxamide 0
                4-Hydroxyphenyl Maraviroc 0
                4-Oxohomoanatoxin-A 0
                4R-Hydroxyhomoanatoxin-A 0
                4S-Hydroxyhomoanatoxin-A 0
                9-Demethoxy-18-demethylgardneramine 0
                Acetylpseudotropine 0
                Anatoxin a 0
                Brugine 0
                Calistegin B2 0
                Calystegine A6 0
                Calystegine A7 0
                Calystegine B5 0
                Calystegine C1 0
                Gardfloramine-N(4)-oxide 0
                Homoanatoxin-a 0
                Knightinol 0
                L-3alpha,6beta-Ditigloyloxytropane 0
                Littorine 0
                Meteloidine 0
                Methyl (2R)-8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate 0
                N-Methylcalystegine B2 0
                N-Methylcalystegine C1 0
                Nor-psi-tropine 0
                O-hydroxy(phenyl)phosphinoyl ecgonine methyl ester 0
                Physoperuvine 0
                Pseudoecgonine 0
                Schizanthine N 0
                Schizanthine O 0
                Schizanthine P 0
                Scopoline 0
                Tigloidine 0
                Valeroidine 0
                [(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate 0
                [(1S,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate 0
                [(6R,7S)-6,7-Dihydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (E)-2-methylbut-2-enoate 0
                atropine oxyde 0
                butylscopolamine + 0
                cocaine 1
                cocaine(1+) + 0
                ecgonine + 0
                ecgonine benzoate 0
                ecgonine methyl ester + 0
                ecgonone methyl ester 0
                gardfloramine 0
                gardneramine 0
                gardneramine-N(4)-oxide 0
                ipratropium + 0
                itasetron 0
                methylatropine 0
                pseudotropine + 0
                scopolamine + 0
                tematropium methylsulfate 0
                tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate + 0
                tropane + 0
                tropanyl 3,5-dimethylbenzoate 0
                tropine + 0
                tropinone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5052
    subatomic particle 5043
      composite particle 5043
        hadron 5071
          baryon 5043
            nucleon 5043
              atomic nucleus 5043
                atom 5043
                  main group element atom 5013
                    p-block element atom 5010
                      carbon group element atom 4927
                        carbon atom 4954
                          organic molecular entity 4926
                            organic molecule 4874
                              organic cyclic compound 4812
                                organic heterocyclic compound 4626
                                  organic heteropolycyclic compound 4424
                                    organic heterobicyclic compound 141
                                      azabicycloalkane 1
                                        tropane alkaloid 1
                                          (2R,3S)-3-Hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid 0
                                          (2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                                          (2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                                          (2S)-3-hydroxy-2-phenylpropanoic acid [(5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                                          (6R)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-one 0
                                          1-(1-adamantyl)-3-[8-[[1-(2-furanylmethyl)-5-tetrazolyl]methyl]-8-azabicyclo[3.2.1]octan-3-yl]urea 0
                                          18-demethylgardfloramine 0
                                          18-demethylgardneramine 0
                                          19(E)-11-Methoxy-9,18-didemethoxygardneramine 0
                                          19(E)-18-Demethoxygardfloramine-N(4)-oxide 0
                                          19(E)-18-demethoxygardfloramine 0
                                          19(E)-18-demethoxygardneramine 0
                                          19(E)-9,18-Didemethoxygardneramine 0
                                          2-(4-bromophenyl)propanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester 0
                                          2-hydroxy-2-phenylacetic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                                          2-hydroxy-2-phenylacetic acid [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                                          2-hydroxy-2-phenylacetic acid [(5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester 0
                                          3,6-Ditigloyloxytropan-7-ol 0
                                          3-hydroxy-2-phenylpropanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester 0
                                          3-hydroxy-2-phenylpropanoic acid (8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl) ester 0
                                          3-hydroxy-2-phenylpropanoic acid [(1R,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                                          3-hydroxy-2-phenylpropanoic acid [(5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                                          3-hydroxy-2-phenylpropanoic acid [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester 0
                                          3alpha-Tigloyloxytropane N-oxide 0
                                          3beta,6beta-Dihydroxynortropane 0
                                          4,4-Difluoro-N-[(1S)-3-[(1R,5S)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboximidic acid 0
                                          4,4-difluoro-N-[(1S)-3-[3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]-1-cyclohexanecarboxamide 0
                                          4-Hydroxyphenyl Maraviroc 0
                                          4-Oxohomoanatoxin-A 0
                                          4R-Hydroxyhomoanatoxin-A 0
                                          4S-Hydroxyhomoanatoxin-A 0
                                          9-Demethoxy-18-demethylgardneramine 0
                                          Acetylpseudotropine 0
                                          Anatoxin a 0
                                          Brugine 0
                                          Calistegin B2 0
                                          Calystegine A6 0
                                          Calystegine A7 0
                                          Calystegine B5 0
                                          Calystegine C1 0
                                          Gardfloramine-N(4)-oxide 0
                                          Homoanatoxin-a 0
                                          Knightinol 0
                                          L-3alpha,6beta-Ditigloyloxytropane 0
                                          Littorine 0
                                          Meteloidine 0
                                          Methyl (2R)-8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate 0
                                          N-Methylcalystegine B2 0
                                          N-Methylcalystegine C1 0
                                          Nor-psi-tropine 0
                                          O-hydroxy(phenyl)phosphinoyl ecgonine methyl ester 0
                                          Physoperuvine 0
                                          Pseudoecgonine 0
                                          Schizanthine N 0
                                          Schizanthine O 0
                                          Schizanthine P 0
                                          Scopoline 0
                                          Tigloidine 0
                                          Valeroidine 0
                                          [(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate 0
                                          [(1S,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate 0
                                          [(6R,7S)-6,7-Dihydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (E)-2-methylbut-2-enoate 0
                                          atropine oxyde 0
                                          butylscopolamine + 0
                                          cocaine 1
                                          cocaine(1+) + 0
                                          ecgonine + 0
                                          ecgonine benzoate 0
                                          ecgonine methyl ester + 0
                                          ecgonone methyl ester 0
                                          gardfloramine 0
                                          gardneramine 0
                                          gardneramine-N(4)-oxide 0
                                          ipratropium + 0
                                          itasetron 0
                                          methylatropine 0
                                          pseudotropine + 0
                                          scopolamine + 0
                                          tematropium methylsulfate 0
                                          tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate + 0
                                          tropane + 0
                                          tropanyl 3,5-dimethylbenzoate 0
                                          tropine + 0
                                          tropinone 0
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