tropane alkaloid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	tropane alkaloid	go back to main search page
Accession:	CHEBI:37332	browse the term
Synonyms:	related_synonym:	tropane alkaloids
	alt_id:	CHEBI:27154; CHEBI:27155

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Rat (1575) Mouse (1571) Human (1569) Chinchilla (0) Bonobo (0) Dog (2) Squirrel (0) Pig (1) Green Monkey (0) Naked Mole-rat (0) All
Genes (1569)

(S)-atropine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

Hyoscyamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638

Anatoxin a

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

anatoxin a inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]

NCBI chr15:32,030,483...32,173,018
Ensembl chr15:31,923,438...32,173,018

atropine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atropine results in decreased activity of ABCB11 protein

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

[Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA

NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675

G

acetylcholinesterase (Yt blood group)

multiple interactions

Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]

PMID:2241428 PMID:10421444 PMID:17963125 PMID:20105433 PMID:21600273 More...

NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974

G

adenylate cyclase 5

increases response to substance

ADCY5 protein results in increased susceptibility to Atropine

NCBI chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090

G

aquaporin 5

multiple interactions

Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein]

NCBI chr12:49,961,872...49,965,682
Ensembl chr12:49,961,872...49,965,682

G

BCL2 associated X, apoptosis regulator

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA]

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCAR1 scaffold protein, Cas family member

multiple interactions

Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]

NCBI chr16:75,228,181...75,268,007
Ensembl chr16:75,228,181...75,268,053

G

butyrylcholinesterase

multiple interactions

[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX

PMID:17963125 PMID:22981459

NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462

G

bradykinin receptor B2

multiple interactions

BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine]

NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166

G

bone morphogenetic protein 6

multiple interactions

Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA]

NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728

G

calcium voltage-gated channel subunit alpha1 E

multiple interactions

Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]

NCBI chr 1:181,317,699...181,808,084
Ensembl chr 1:181,317,690...181,813,262

G

calcitonin related polypeptide alpha

affects activity

Atropine affects the activity of CALCA protein

PMID:7906887 PMID:10075105

NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354

G

caspase 3

increases expression

Atropine results in increased expression of CASP3 mRNA

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

C-C motif chemokine ligand 5

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein]

NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793

G

cyclin A1

increases expression
multiple interactions

Atropine results in increased expression of CCNA1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA

NCBI chr13:36,431,517...36,442,870
Ensembl chr13:36,431,520...36,442,870

G

cyclin D3

multiple interactions

[Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA

NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357

G

cyclin E1

increases expression
multiple interactions

Atropine results in increased expression of CCNE1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA

NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312

G

cyclin E2

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA
Atropine results in increased expression of CCNE2 mRNA

NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678

G

CD40 molecule

multiple interactions

Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein]

NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863

G

cell division cycle 20

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA
Atropine results in increased expression of CDC20 mRNA

NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203

G

cell division cycle 6

multiple interactions

[Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA

NCBI chr17:40,287,879...40,304,657
Ensembl chr17:40,287,879...40,304,657

G

cyclin dependent kinase 1

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA
Atropine results in increased expression of CDK1 mRNA

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

carboxylesterase 1

multiple interactions

Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]

NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337

G

cholinergic receptor muscarinic 1

multiple interactions
decreases activity

Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Atropine results in decreased activity of CHRM1 protein
Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]

PMID:16439611 PMID:18316702 PMID:31830555

NCBI chr11:62,908,679...62,921,878
Ensembl chr11:62,908,679...62,921,807

G

cholinergic receptor muscarinic 2

multiple interactions

Atropine binds to and results in decreased activity of CHRM2 protein

NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255

G

cholinergic receptor muscarinic 3

multiple interactions
decreases activity

Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]
Atropine results in decreased activity of CHRM3 protein

PMID:15140916 PMID:20708676 PMID:31830555

NCBI chr 1:239,386,568...239,915,450
Ensembl chr 1:239,386,565...239,915,452

G

cholinergic receptor muscarinic 4

multiple interactions
affects binding

[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein]

NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,383,789...46,391,776

G

cholinergic receptor muscarinic 5

multiple interactions

Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein]

NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions
affects binding

Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]

PMID:15733544 PMID:21791372

NCBI chr20:63,343,223...63,361,349
Ensembl chr20:63,343,223...63,378,401

G

cholinergic receptor nicotinic beta 2 subunit

affects binding
multiple interactions

Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]

PMID:15733544 PMID:21791372

NCBI chr 1:154,567,778...154,580,013
Ensembl chr 1:154,567,778...154,580,013

G

cAMP responsive element binding protein 1

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein]

NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988

G

corticotropin releasing hormone

multiple interactions

Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]
[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein

PMID:12039681 PMID:12906840

NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464

G

catenin beta 1

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein]

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

G

C-X-C motif chemokine ligand 1

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein]

NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308

G

dishevelled segment polarity protein 2

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein]

NCBI chr17:7,225,342...7,234,517
Ensembl chr17:7,225,342...7,234,517

G

endothelin 1

multiple interactions

EDN1 protein results in decreased activity of [Atropine co-treated with Histamine]

NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194

G

eukaryotic translation elongation factor 2

multiple interactions

atropine inhibits the reaction [carbachol decreases phosphorylation of EEF2 protein in colon cancer cells]

RGD

NCBI chr19:3,976,056...3,985,463
Ensembl chr19:3,976,056...3,985,463

G

epidermal growth factor receptor

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein]

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

early growth response 1

multiple interactions

Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

G

early growth response 2

multiple interactions

Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]

NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,819,167

G

ezrin

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of EZR protein]

NCBI chr 6:158,765,748...158,819,368
Ensembl chr 6:158,765,741...158,819,368

G

coagulation factor II, thrombin

multiple interactions

[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein

NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506

G

coagulation factor II thrombin receptor

multiple interactions

[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein

NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Atropine results in increased expression of FOS protein
Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]

PMID:7968354 PMID:8281324 PMID:21787676 PMID:21971501

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

G

ghrelin and obestatin prepropeptide

multiple interactions

Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein]

NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947

G

glycine receptor alpha 1

multiple interactions

Atropine binds to and results in decreased activity of GLRA1 protein

NCBI chr 5:151,822,513...151,924,851
Ensembl chr 5:151,822,513...151,924,851

G

glutamate metabotropic receptor 4

multiple interactions

Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr 6:34,018,643...34,155,622
Ensembl chr 6:34,018,643...34,155,622

G

intercellular adhesion molecule 1

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein]

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

interleukin 1 beta

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions

[Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein]

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]

NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315

G

potassium inwardly rectifying channel subfamily J member 3

multiple interactions

Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr 2:154,698,695...154,858,354
Ensembl chr 2:154,697,855...154,858,354

G

KIT proto-oncogene, receptor tyrosine kinase

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of KIT protein]

NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783

G

lactotransferrin

multiple interactions

Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein]

NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234

G

mitogen-activated protein kinase 1

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 14

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein]

NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236

G

mitogen-activated protein kinase 3

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein]

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

minichromosome maintenance complex component 4

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA
Atropine results in increased expression of MCM4 mRNA

NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160

G

minichromosome maintenance complex component 6

increases expression
multiple interactions

Atropine results in increased expression of MCM6 mRNA
[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA

NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443

G

neurofilament heavy chain

affects expression

Atropine affects the expression of NEFH mRNA

NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390

G

NLR family pyrin domain containing 3

increases expression

Atropine results in increased expression of NLRP3 mRNA

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108

G

nitric oxide synthase 2

multiple interactions

Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]

PMID:15610444 PMID:16944022

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

notch receptor 4

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein]

NCBI chr 6:32,194,843...32,224,067
Ensembl chr 6:32,194,843...32,224,067

G

natriuretic peptide A

affects activity

Atropine affects the activity of NPPA protein modified form

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

G

opioid related nociceptin receptor 1

multiple interactions

Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]

NCBI chr20:64,080,082...64,100,643
Ensembl chr20:64,080,082...64,100,643

G

proliferating cell nuclear antigen

multiple interactions

Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA]

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

G

prepronociceptin

multiple interactions

Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]

NCBI chr 8:28,316,988...28,343,351
Ensembl chr 8:28,316,986...28,343,355

G

proopiomelanocortin

multiple interactions

Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein]

NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903

G

peroxisome proliferator activated receptor alpha

multiple interactions

[Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]

NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA]

PMID:15104355 PMID:15610444 PMID:16259740 PMID:16804302

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

protein tyrosine kinase 2

multiple interactions

Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]]

NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216

G

paxillin

multiple interactions

Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]

NCBI chr12:120,210,447...120,265,730
Ensembl chr12:120,210,439...120,265,771

G

Rac family small GTPase 3

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein]

NCBI chr17:82,031,678...82,034,204
Ensembl chr17:82,031,678...82,034,204

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein]

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

ras homolog family member A

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein]

NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998

G

solute carrier family 22 member 1

multiple interactions

Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

PMID:16263091 PMID:21641380

NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718

G

solute carrier family 22 member 2

multiple interactions

Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]

PMID:16263091 PMID:21599003 PMID:23770354

NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638

G

solute carrier family 22 member 3

increases uptake
multiple interactions

SLC22A3 protein results in increased uptake of Atropine
Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]

NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577

G

solute carrier family 22 member 4

multiple interactions

Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]

NCBI chr 5:132,294,394...132,344,190
Ensembl chr 5:132,294,394...132,344,190

G

solute carrier family 47 member 1

multiple interactions

Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034

G

solute carrier family 47 member 2

multiple interactions

Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr17:19,678,317...19,718,979
Ensembl chr17:19,678,288...19,718,979

G

secretory leukocyte peptidase inhibitor

increases expression

Atropine results in increased expression of SLPI mRNA

NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564

G

suppressor of cytokine signaling 3

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA]

NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077

G

sialophorin

increases response to substance

SPN protein results in increased susceptibility to Atropine

NCBI chr16:29,662,963...29,670,876
Ensembl chr16:29,662,979...29,670,876

G

tyrosine aminotransferase

multiple interactions

[Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein]

NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092

G

transforming growth factor beta 1

multiple interactions

Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

tumor necrosis factor

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein]

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

tumor protein p53

multiple interactions

Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein]

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

trio Rho guanine nucleotide exchange factor

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein]

NCBI chr 5:14,143,342...14,510,204
Ensembl chr 5:14,143,342...14,532,128

G

transient receptor potential cation channel subfamily A member 1

decreases response to substance

TRPA1 gene mutant form results in decreased susceptibility to Atropine

NCBI chr 8:72,021,250...72,090,010
Ensembl chr 8:72,019,917...72,075,584

G

thyroid stimulating hormone subunit beta

multiple interactions

[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein]

NCBI chr 1:115,029,826...115,034,309
Ensembl chr 1:115,029,826...115,034,302

G

translocator protein

multiple interactions

[Ketamine co-treated with Midazolam co-treated with Valproic Acid] inhibits the reaction [[Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein]; [Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein

NCBI chr22:43,151,559...43,163,242
Ensembl chr22:43,151,547...43,163,242

G

vascular cell adhesion molecule 1

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA]

NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045

butylscopolamine bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

Butylscopolammonium Bromide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638

cocaine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetoacetyl-CoA synthetase

affects expression

Cocaine affects the expression of AACS mRNA

NCBI chr12:125,065,435...125,143,316
Ensembl chr12:125,065,434...125,143,333

G

arylacetamide deacetylase

decreases expression

Cocaine results in decreased expression of AADAC mRNA

NCBI chr 3:151,814,116...151,828,488
Ensembl chr 3:151,814,073...151,828,488

G

aralkylamine N-acetyltransferase

affects response to substance

AANAT protein affects the susceptibility to Cocaine

NCBI chr17:76,453,351...76,470,117
Ensembl chr17:76,453,351...76,470,117

G

4-aminobutyrate aminotransferase

increases response to substance

ABAT mRNA results in increased susceptibility to Cocaine

NCBI chr16:8,674,617...8,784,570
Ensembl chr16:8,674,596...8,784,575

G

ATP binding cassette subfamily A member 4

decreases expression

Cocaine results in decreased expression of ABCA4 mRNA

NCBI chr 1:93,992,834...94,121,148
Ensembl chr 1:93,992,834...94,121,148

G

ATP binding cassette subfamily A member 5

multiple interactions

HDAC5 affects the reaction [Cocaine affects the expression of ABCA5 mRNA]

NCBI chr17:69,244,311...69,327,133
Ensembl chr17:69,244,311...69,327,244

G

ATP binding cassette subfamily C member 3

affects expression

Cocaine affects the expression of ABCC3 mRNA

NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253

G

ATP binding cassette subfamily C member 5

affects expression

Cocaine affects the expression of ABCC5 mRNA

NCBI chr 3:183,919,934...184,017,884
Ensembl chr 3:183,919,934...184,017,939

G

ATP binding cassette subfamily C member 9

affects expression

Cocaine affects the expression of ABCC9 mRNA

NCBI chr12:21,797,389...21,941,426
Ensembl chr12:21,797,389...21,942,543

G

ATP binding cassette subfamily D member 4

affects expression

Cocaine affects the expression of ABCD4 mRNA

NCBI chr14:74,285,269...74,302,934
Ensembl chr14:74,285,269...74,303,055

G

abhydrolase domain containing 1

decreases expression

Cocaine results in decreased expression of ABHD1 mRNA

NCBI chr 2:27,123,815...27,130,812
Ensembl chr 2:27,123,789...27,130,812

G

abhydrolase domain containing 14A

affects expression

Cocaine affects the expression of ABHD14A mRNA

NCBI chr 3:51,975,064...51,981,196
Ensembl chr 3:51,971,426...51,981,196

G

abhydrolase domain containing 17A, depalmitoylase

affects expression

Cocaine affects the expression of ABHD17A mRNA

NCBI chr19:1,876,810...1,885,496
Ensembl chr19:1,876,810...1,885,496

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

affects expression

Cocaine affects the expression of ABL1 mRNA

NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675

G

acetyl-CoA acyltransferase 1

increases expression

Cocaine results in increased expression of ACAA1 mRNA

NCBI chr 3:38,122,715...38,137,127
Ensembl chr 3:38,103,129...38,137,242

G

aggrecan

affects expression

Cocaine affects the expression of ACAN mRNA

NCBI chr15:88,803,436...88,875,353
Ensembl chr15:88,803,436...88,875,353

G

angiotensin I converting enzyme

multiple interactions

ACE inhibits the reaction [Cocaine affects the abundance of Dinoprostone]; ACE inhibits the reaction [Cocaine affects the abundance of Epoprostenol]

NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380

G

apoptotic chromatin condensation inducer 1

affects expression

Cocaine affects the expression of ACIN1 mRNA

NCBI chr14:23,058,564...23,095,614
Ensembl chr14:23,058,564...23,095,614

G

atypical chemokine receptor 2

affects expression

Cocaine affects the expression of ACKR2 mRNA

NCBI chr 3:42,809,445...42,867,286
Ensembl chr 3:42,804,752...42,887,974

G

aconitase 2

increases expression

Cocaine results in increased expression of ACO2 protein modified form

NCBI chr22:41,469,117...41,528,974
Ensembl chr22:41,447,830...41,529,273

G

acyl-CoA synthetase long chain family member 5

affects expression

Cocaine affects the expression of ACSL5 mRNA

NCBI chr10:112,374,116...112,428,376
Ensembl chr10:112,374,116...112,428,379

G

acyl-CoA synthetase short chain family member 1

decreases expression

Cocaine results in decreased expression of ACSS1 mRNA

NCBI chr20:25,006,237...25,058,139
Ensembl chr20:25,006,230...25,058,980

G

actin gamma 2, smooth muscle

decreases expression

Cocaine results in decreased expression of ACTG2 mRNA

NCBI chr 2:73,893,008...73,919,865
Ensembl chr 2:73,892,314...73,919,865

G

actinin alpha 2

increases expression

Cocaine results in increased expression of ACTN2 mRNA

PMID:15009677 PMID:16710320

NCBI chr 1:236,686,499...236,764,631
Ensembl chr 1:236,664,141...236,764,631

G

activin A receptor type 1C

increases expression

Cocaine results in increased expression of ACVR1C mRNA

NCBI chr 2:157,526,767...157,628,864
Ensembl chr 2:157,526,767...157,628,864

G

aminoacylase 3

affects expression

Cocaine affects the expression of ACY3 mRNA

NCBI chr11:67,642,555...67,650,730
Ensembl chr11:67,642,555...67,650,730

G

ADAM metallopeptidase domain 19

decreases expression

Cocaine results in decreased expression of ADAM19 mRNA

NCBI chr 5:157,477,304...157,575,775
Ensembl chr 5:157,395,534...157,575,775

G

ADAM metallopeptidase domain 1A (pseudogene)

multiple interactions

HDAC5 affects the reaction [Cocaine affects the expression of ADAM1A mRNA]

NCBI chr12:111,899,063...111,901,902
Ensembl chr12:111,899,263...111,901,391

G

ADAM metallopeptidase with thrombospondin type 1 motif 19

decreases expression

Cocaine results in decreased expression of ADAMTS19 mRNA

NCBI chr 5:129,460,298...129,738,683
Ensembl chr 5:129,460,281...129,738,683

G

adenosine deaminase tRNA specific 2

decreases expression

Cocaine results in decreased expression of ADAT2 mRNA

NCBI chr 6:143,422,832...143,450,695
Ensembl chr 6:143,422,832...143,450,695

G

adenylate cyclase 2

affects expression

Cocaine affects the expression of ADCY2 mRNA

NCBI chr 5:7,396,138...7,830,081
Ensembl chr 5:7,396,138...7,830,081

G

adenylate cyclase 8

affects expression

Cocaine affects the expression of ADCY8 mRNA

NCBI chr 8:130,780,301...131,040,909
Ensembl chr 8:130,780,301...131,040,909

G

adenylate cyclase activating polypeptide 1

multiple interactions
increases expression

ADCYAP1 protein modified form affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; ADCYAP1 protein modified form affects the reaction [Cocaine results in increased expression of BAX protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]; IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]; TNF protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]

NCBI chr18:904,411...912,172
Ensembl chr18:904,871...912,172

G

ADCYAP receptor type I

multiple interactions
increases expression

alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]; IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]; TNF protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]

NCBI chr 7:31,052,308...31,111,474
Ensembl chr 7:31,052,308...31,111,474

G

adhesion G protein-coupled receptor A1

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in increased expression of ADGRA1 mRNA

NCBI chr10:133,087,924...133,131,675
Ensembl chr10:133,087,924...133,131,675

G

adhesion G protein-coupled receptor E1

affects expression

Cocaine affects the expression of ADGRE1 mRNA

NCBI chr19:6,887,579...6,940,450
Ensembl chr19:6,887,566...6,940,459

G

adhesion G protein-coupled receptor F1

decreases expression

Cocaine results in decreased expression of ADGRF1 mRNA

NCBI chr 6:46,997,708...47,042,332
Ensembl chr 6:46,997,708...47,042,350

G

adhesion G protein-coupled receptor L1

affects expression

Cocaine affects the expression of ADGRL1 mRNA

NCBI chr19:14,147,743...14,206,169
Ensembl chr19:14,147,743...14,206,187

G

adhesion G protein-coupled receptor L3

affects expression

Cocaine affects the expression of ADGRL3 mRNA

NCBI chr 4:61,200,326...62,078,335
Ensembl chr 4:61,200,326...62,078,335

G

adenosine A1 receptor

affects expression
affects response to substance

Cocaine affects the expression of ADORA1 mRNA; Cocaine affects the expression of ADORA1 protein
ADORA1 affects the susceptibility to Cocaine

PMID:12358776 PMID:19092996

NCBI chr 1:203,127,726...203,167,405
Ensembl chr 1:203,090,654...203,167,405

G

adenosine A2a receptor

increases response to substance
increases expression

ADORA2A results in increased susceptibility to Cocaine
Cocaine deficiency results in increased expression of ADORA2A mRNA

PMID:16123743 PMID:27126842

NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357

G

adenosine A2b receptor

affects expression

Cocaine affects the expression of ADORA2B mRNA

NCBI chr17:15,850,362...15,975,746
Ensembl chr17:15,945,130...15,975,746

G

adrenoceptor alpha 1B

increases response to substance

ADRA1B gene results in increased susceptibility to Cocaine

NCBI chr 5:159,865,086...159,989,205
Ensembl chr 5:159,865,080...159,973,012

G

adrenoceptor beta 1

multiple interactions
affects expression

Betaxolol affects the reaction [Cocaine affects the expression of ADRB1 protein]; Betaxolol inhibits the reaction [Cocaine affects the expression of ADRB1 protein]

PMID:17513029 PMID:18596687

NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904

G

ALF transcription elongation factor 4

increases expression

Cocaine results in increased expression of AFF4 mRNA

NCBI chr 5:132,875,395...132,963,634
Ensembl chr 5:132,875,395...132,963,634

G

arylformamidase

increases expression

Cocaine results in increased expression of AFMID mRNA

NCBI chr17:78,187,362...78,207,702
Ensembl chr17:78,187,358...78,207,702

G

alpha fetoprotein

increases expression

Cocaine results in increased expression of AFP mRNA

NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174

G

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

affects expression

Cocaine affects the expression of AGAP2 mRNA

NCBI chr12:57,723,761...57,742,161
Ensembl chr12:57,723,761...57,742,157

G

argonaute RISC catalytic component 2

multiple interactions
affects response to substance

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR130A mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR136 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR137 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR138-1 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR148B mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR154 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR181A1 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR186 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR301B mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR324 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR337 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR369 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR376A mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR376C mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR380 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR384 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR467B mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR488 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR500 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR544 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR665 mRNA]
AGO2 protein affects the susceptibility to Cocaine

NCBI chr 8:140,520,156...140,642,313
Ensembl chr 8:140,520,156...140,635,633

G

allograft inflammatory factor 1 like

decreases expression

Cocaine results in decreased expression of AIF1L mRNA

NCBI chr 9:131,096,531...131,123,144
Ensembl chr 9:131,096,476...131,123,152

G

apoptosis inducing factor mitochondria associated 1

affects expression
increases expression

Cocaine affects the expression of AIFM1 mRNA
Cocaine results in increased expression of AIFM1 mRNA

PMID:15681117 PMID:18000554

NCBI chr X:130,129,362...130,165,841
Ensembl chr X:130,124,666...130,165,879

G

apoptosis inducing factor mitochondria associated 2

affects expression

Cocaine affects the expression of AIFM2 mRNA

NCBI chr10:70,112,271...70,132,825
Ensembl chr10:70,098,223...70,132,934

G

adenylate kinase 1

decreases expression

Cocaine results in decreased expression of AK1 mRNA

NCBI chr 9:127,866,480...127,879,621
Ensembl chr 9:127,866,486...127,877,675

G

adenylate kinase 3

affects expression

Cocaine affects the expression of AK3 mRNA

NCBI chr 9:4,709,556...4,742,043
Ensembl chr 9:4,709,556...4,742,043

G

aldo-keto reductase family 1 member D1

affects expression

Cocaine affects the expression of AKR1D1 mRNA

NCBI chr 7:138,076,459...138,118,305
Ensembl chr 7:138,002,324...138,118,305

G

aldo-keto reductase family 1 member E2

affects expression

Cocaine affects the expression of AKR1E1 mRNA

NCBI chr10:4,824,973...4,873,237
Ensembl chr10:4,786,629...4,848,062

G

aldo-keto reductase family 7 member A3

affects expression

Cocaine affects the expression of AKR7A3 mRNA

NCBI chr 1:19,274,229...19,288,770
Ensembl chr 1:19,282,573...19,288,770

G

AKT serine/threonine kinase 1

affects expression
multiple interactions
increases phosphorylation

Cocaine affects the expression of AKT1 mRNA
[Cocaine co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased phosphorylation of AKT1 protein
Cocaine results in increased phosphorylation of AKT1 protein
Cocaine affects the reaction [ILK protein affects the phosphorylation of AKT1 protein]

PMID:18702665 PMID:20187946 PMID:25933444

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

activated leukocyte cell adhesion molecule

increases expression

Cocaine results in increased expression of ALCAM mRNA

NCBI chr 3:105,366,909...105,576,900
Ensembl chr 3:105,366,909...105,576,900

G

aldehyde dehydrogenase 2 family member

multiple interactions

[[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline] inhibits the reaction [Cocaine results in increased abundance of and results in increased secretion of Dopamine]; [ALDH2 protein affects the abundance of Tetrahydropapaveroline] which affects the susceptibility to Cocaine; ALDH2 protein affects the reaction [Cocaine results in increased abundance of Dopamine]

NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532

G

autophagy and beclin 1 regulator 1

decreases expression

Cocaine results in decreased expression of AMBRA1 mRNA

NCBI chr11:46,396,412...46,594,023
Ensembl chr11:46,396,414...46,594,125

G

anti-Mullerian hormone

increases expression

Cocaine results in increased expression of AMH mRNA

NCBI chr19:2,249,323...2,252,073
Ensembl chr19:2,249,309...2,252,073

G

adhesion molecule with Ig like domain 1

affects expression

Cocaine affects the expression of AMIGO1 mRNA

NCBI chr 1:109,504,178...109,509,727
Ensembl chr 1:109,504,178...109,509,738

G

adhesion molecule with Ig like domain 3

affects expression

Cocaine affects the expression of AMIGO3 mRNA

NCBI chr 3:49,716,829...49,719,684
Ensembl chr 3:49,716,829...49,719,684

G

antagonist of mitotic exit network 1 homolog

decreases expression

Cocaine results in decreased expression of AMN1 mRNA

NCBI chr12:31,671,137...31,729,174
Ensembl chr12:31,671,142...31,729,121

G

ankyrin repeat domain 54

affects expression

Cocaine affects the expression of ANKRD54 mRNA

NCBI chr22:37,830,855...37,849,341
Ensembl chr22:37,830,855...37,849,327

G

ankyrin repeat and sterile alpha motif domain containing 1B

decreases expression

Cocaine results in decreased expression of ANKS1B mRNA

NCBI chr12:98,734,786...99,984,936
Ensembl chr12:98,726,457...99,984,936

G

annexin A7

affects expression

Cocaine affects the expression of ANXA7 mRNA

NCBI chr10:73,375,101...73,414,058
Ensembl chr10:73,375,101...73,414,076

G

adaptor related protein complex 1 associated regulatory protein

increases expression

Cocaine results in increased expression of AP1AR mRNA

NCBI chr 4:112,231,787...112,273,110
Ensembl chr 4:112,231,740...112,273,110

G

adaptor related protein complex 2 subunit beta 1

affects expression

Cocaine affects the expression of AP2B1 mRNA

NCBI chr17:35,587,322...35,726,413
Ensembl chr17:35,578,046...35,726,413

G

adaptor related protein complex 2 subunit mu 1

increases expression

Cocaine results in increased expression of AP2M1 protein

NCBI chr 3:184,174,855...184,184,091
Ensembl chr 3:184,174,689...184,184,214

G

adaptor related protein complex 2 subunit sigma 1

decreases expression

Cocaine results in decreased expression of AP2S1 mRNA

NCBI chr19:46,838,167...46,850,846
Ensembl chr19:46,838,136...46,850,846

G

adaptor related protein complex 5 subunit mu 1

affects expression

Cocaine affects the expression of AP5M1 mRNA

NCBI chr14:57,268,971...57,298,742
Ensembl chr14:57,268,924...57,298,742

G

amyloid P component, serum

increases expression

Cocaine results in increased expression of APCS protein

NCBI chr 1:159,587,826...159,588,865
Ensembl chr 1:159,587,826...159,588,865

G

aph-1 homolog A, gamma-secretase subunit

affects expression

Cocaine affects the expression of APH1A mRNA

NCBI chr 1:150,265,404...150,269,016
Ensembl chr 1:150,265,399...150,269,580

G

apelin receptor

increases expression

Cocaine results in increased expression of APLNR mRNA

NCBI chr11:57,233,591...57,237,250
Ensembl chr11:57,233,577...57,237,250

G

apolipoprotein L2

increases expression

Cocaine results in increased expression of APOL2 mRNA

NCBI chr22:36,226,209...36,239,954
Ensembl chr22:36,226,209...36,239,954

G

apolipoprotein L domain containing 1

affects expression

Cocaine affects the expression of APOLD1 mRNA

NCBI chr12:12,725,917...12,791,466
Ensembl chr12:12,725,917...12,829,975

G

apolipoprotein O

increases expression

Cocaine results in increased expression of APOO protein

NCBI chr X:23,833,353...23,907,938
Ensembl chr X:23,833,353...23,907,938

G

amyloid beta precursor protein

decreases expression
increases expression

Cocaine results in decreased expression of APP mRNA
Cocaine results in increased expression of APP mRNA

PMID:15009677 PMID:16710320 PMID:17898221

NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128

G

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

increases expression

Cocaine results in increased expression of APPL1 mRNA

NCBI chr 3:57,227,729...57,273,471
Ensembl chr 3:57,227,726...57,278,105

G

activity regulated cytoskeleton associated protein

affects expression
multiple interactions
increases expression

Cocaine affects the expression of ARC mRNA
cocaine co treated with anisomycin decreases expression of Arc protein in dorsal striatum and shell of nucleus accumbens
Cocaine increases expression of Arc protein in dorsal striatum and shell of nucleus accumbens
Cocaine results in increased expression of ARC mRNA; Cocaine results in increased expression of ARC protein
Reserpine inhibits the reaction [Cocaine results in increased expression of ARC mRNA]

CTD
RGD

PMID:7722525 PMID:12117546 PMID:15254092 PMID:17851536 PMID:18311559 More...

RGD:401901591, RGD:401901591

NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479

G

ADP ribosylation factor 4

decreases expression

Cocaine results in decreased expression of ARF4 protein

NCBI chr 3:57,571,363...57,597,344
Ensembl chr 3:57,571,363...57,598,220

G

Rho GTPase activating protein 1

increases expression

Cocaine results in increased expression of ARHGAP1 protein

NCBI chr11:46,677,080...46,700,619
Ensembl chr11:46,677,080...46,700,619

G

Rho GTPase activating protein 29

decreases expression

Cocaine results in decreased expression of ARHGAP29 mRNA

NCBI chr 1:94,168,905...94,314,592
Ensembl chr 1:94,148,988...94,275,068

G

Rho GTPase activating protein 30

increases expression

Cocaine results in increased expression of ARHGAP30 mRNA

NCBI chr 1:161,046,946...161,069,891
Ensembl chr 1:161,046,946...161,069,970

G

Rho GTPase activating protein 44

decreases expression

Cocaine results in decreased expression of ARHGAP44 protein

NCBI chr17:12,789,498...12,991,643
Ensembl chr17:12,789,498...12,991,643

G

Rho GTPase activating protein 5

increases expression

Cocaine results in increased expression of ARHGAP5 mRNA

NCBI chr14:32,077,304...32,159,728
Ensembl chr14:32,076,114...32,159,728

G

Rho GTPase activating protein 9

decreases expression

Cocaine results in decreased expression of ARHGAP9 mRNA

NCBI chr12:57,472,269...57,488,824
Ensembl chr12:57,472,264...57,488,814

G

Rho guanine nucleotide exchange factor 1

affects expression

Cocaine affects the expression of ARHGEF1 mRNA

NCBI chr19:41,883,184...41,930,141
Ensembl chr19:41,883,173...41,930,150

G

Rho guanine nucleotide exchange factor 7

affects expression

Cocaine affects the expression of ARHGEF7 mRNA

NCBI chr13:111,114,619...111,305,734
Ensembl chr13:111,114,559...111,305,737

G

armadillo repeat containing X-linked 6

affects expression

Cocaine affects the expression of ARMCX6 mRNA

NCBI chr X:101,615,125...101,618,000
Ensembl chr X:101,615,118...101,618,001

G

actin related protein 2/3 complex subunit 1A

increases expression

Cocaine results in increased expression of ARPC1A protein

NCBI chr 7:99,325,898...99,366,262
Ensembl chr 7:99,325,898...99,366,262

G

cAMP regulated phosphoprotein 19

multiple interactions

Cocaine inhibits the reaction [SK&F 81297 results in increased phosphorylation of ARPP19 protein]

NCBI chr15:52,547,045...52,569,446
Ensembl chr15:52,547,045...52,569,883

G

cAMP regulated phosphoprotein 21

multiple interactions
increases expression

Cocaine inhibits the reaction [SK&F 81297 results in increased phosphorylation of ARPP21 protein]
Cocaine deficiency results in increased expression of ARPP21 mRNA

PMID:11268215 PMID:27126842

NCBI chr 3:35,638,853...35,794,486
Ensembl chr 3:35,638,945...35,794,496

G

ADP-ribosyltransferase 5

increases expression

Cocaine results in increased expression of ART5 mRNA

NCBI chr11:3,638,512...3,642,379
Ensembl chr11:3,638,512...3,642,316

G

arsenite methyltransferase

affects expression

Cocaine affects the expression of AS3MT mRNA

NCBI chr10:102,869,470...102,901,899
Ensembl chr10:102,869,470...102,901,899

G

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

decreases expression

Cocaine results in decreased expression of ASAP1 mRNA

NCBI chr 8:130,052,104...130,443,674
Ensembl chr 8:130,052,104...130,443,674

G

ATPase family AAA domain containing 1

increases expression

Cocaine results in increased expression of ATAD1 mRNA

NCBI chr10:87,751,512...87,841,361
Ensembl chr10:87,751,512...87,841,361

G

ATPase family AAA domain containing 5

decreases expression

Cocaine results in decreased expression of ATAD5 mRNA

NCBI chr17:30,831,966...30,895,869
Ensembl chr17:30,831,966...30,895,869

G

arginyltransferase 1

increases expression

Cocaine results in increased expression of ATE1 mRNA

NCBI chr10:121,740,424...121,928,463
Ensembl chr10:121,709,393...121,928,801

G

activating transcription factor 3

increases expression
decreases expression

Cocaine results in increased expression of ATF3 mRNA
Cocaine results in decreased expression of ATF3 mRNA

PMID:23644055 PMID:27899881

NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777

G

activating transcription factor 4

increases expression

Cocaine results in increased expression of ATF4; Cocaine results in increased expression of ATF4 mRNA

PMID:18593214 PMID:23644055

NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683

G

activating transcription factor 6

affects expression

Cocaine affects the expression of ATF6 mRNA

NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574

G

activating transcription factor 7

affects expression

Cocaine affects the expression of ATF7 mRNA

NCBI chr12:53,507,856...53,626,382
Ensembl chr12:53,507,856...53,626,410

G

autophagy related 2B

affects expression

Cocaine affects the expression of ATG2B mRNA

NCBI chr14:96,279,195...96,363,341
Ensembl chr14:96,279,195...96,363,341

G

autophagy related 4B cysteine peptidase

affects expression

Cocaine affects the expression of ATG4B mRNA

NCBI chr 2:241,637,693...241,673,857
Ensembl chr 2:241,637,213...241,673,857

G

ATM serine/threonine kinase

multiple interactions
increases expression

EHMT2 inhibits the reaction [Cocaine results in increased expression of ATM mRNA]

NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102

G

ATPase phospholipid transporting 10A (putative)

decreases expression

Cocaine results in decreased expression of ATP10A mRNA

PMID:17898221 PMID:27899881

NCBI chr15:25,672,237...25,865,088
Ensembl chr15:25,677,273...25,865,184

G

ATPase Na+/K+ transporting subunit alpha 1

affects expression

Cocaine affects the expression of ATP1A1 mRNA

NCBI chr 1:116,373,244...116,404,774
Ensembl chr 1:116,372,668...116,410,261

G

ATPase Na+/K+ transporting subunit alpha 3

increases expression
affects expression

Cocaine results in increased expression of ATP1A3 mRNA
Cocaine affects the expression of ATP1A3 mRNA

PMID:16076954 PMID:20187946

NCBI chr19:41,966,582...41,994,230
Ensembl chr19:41,966,582...41,997,497

G

ATPase Na+/K+ transporting subunit beta 2

increases expression

Cocaine results in increased expression of ATP1B2 mRNA

NCBI chr17:7,646,627...7,657,770
Ensembl chr17:7,646,627...7,657,770

G

ATPase Na+/K+ transporting subunit beta 3

increases expression
multiple interactions

Cocaine results in increased expression of ATP1B3 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ATP1B3 mRNA]

NCBI chr 3:141,876,643...141,926,549
Ensembl chr 3:141,876,124...141,926,549

G

ATP synthase F1 subunit alpha

affects expression

Cocaine affects the expression of ATP5F1A protein

NCBI chr18:46,080,248...46,104,227
Ensembl chr18:46,080,248...46,104,334

G

ATP synthase F1 subunit beta

decreases expression

Cocaine results in decreased expression of ATP5F1B protein

NCBI chr12:56,638,175...56,645,984
Ensembl chr12:56,638,175...56,645,984

G

ATP synthase F1 subunit epsilon

affects expression

Cocaine affects the expression of ATP5F1E mRNA

NCBI chr20:59,025,475...59,032,335
Ensembl chr20:59,025,475...59,032,345

G

ATP synthase membrane subunit c locus 3

decreases expression
affects expression

Cocaine results in decreased expression of ATP5MC3 mRNA
Cocaine affects the expression of ATP5MC3 mRNA

PMID:12629581 PMID:20187946

NCBI chr 2:175,176,258...175,181,710
Ensembl chr 2:175,176,258...175,181,710

G

ATP synthase peripheral stalk-membrane subunit b

affects expression

Cocaine affects the expression of ATP5PB mRNA

NCBI chr 1:111,449,464...111,462,773
Ensembl chr 1:111,448,864...111,462,773

G

ATP synthase peripheral stalk subunit d

affects expression

Cocaine affects the expression of ATP5PD mRNA

NCBI chr17:75,038,863...75,046,969
Ensembl chr17:75,038,863...75,046,985

G

ATPase H+ transporting V1 subunit D

affects expression

Cocaine affects the expression of ATP6V1D mRNA

NCBI chr14:67,337,872...67,359,804
Ensembl chr14:67,294,371...67,360,265

G

ATPase phospholipid transporting 8B2

increases expression
multiple interactions

Cocaine results in increased expression of ATP8B2 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ATP8B2 mRNA]

NCBI chr 1:154,325,525...154,351,304
Ensembl chr 1:154,325,525...154,351,304

G

ATPase phospholipid transporting 9B (putative)

affects response to substance

ATP9B gene SNP affects the susceptibility to Cocaine

NCBI chr18:79,069,394...79,378,283
Ensembl chr18:79,069,285...79,378,287

G

ATP synthase mitochondrial F1 complex assembly factor 1

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of ATPAF1 mRNA

NCBI chr 1:46,632,737...46,668,557
Ensembl chr 1:46,632,737...46,673,867

G

ATRX chromatin remodeler

increases expression

Cocaine results in increased expression of ATRX mRNA

NCBI chr X:77,504,880...77,786,216
Ensembl chr X:77,504,880...77,786,233

G

ataxin 1

affects expression

Cocaine affects the expression of ATXN1 mRNA

NCBI chr 6:16,299,112...16,761,460
Ensembl chr 6:16,299,112...16,761,491

G

ataxin 3

decreases expression

Cocaine results in decreased expression of ATXN3 mRNA

NCBI chr14:92,044,775...92,106,582
Ensembl chr14:92,044,496...92,106,621

G

alpha-2-glycoprotein 1, zinc-binding

decreases expression

Cocaine results in decreased expression of AZGP1 mRNA

NCBI chr 7:99,966,730...99,976,031
Ensembl chr 7:99,966,720...99,976,042

G

BAALC binder of MAP3K1 and KLF4

decreases expression

Cocaine results in decreased expression of BAALC mRNA

NCBI chr 8:103,140,725...103,230,305
Ensembl chr 8:103,140,713...103,230,305

G

BTB domain and CNC homolog 1

increases expression

Cocaine results in increased expression of BACH1 mRNA

NCBI chr21:29,298,922...29,361,894
Ensembl chr21:29,194,071...29,630,751

G

BTB domain and CNC homolog 2

affects expression

Cocaine affects the expression of BACH2 mRNA

NCBI chr 6:89,926,528...90,296,843
Ensembl chr 6:89,926,528...90,296,843

G

BCL2 associated agonist of cell death

affects expression

Cocaine affects the expression of BAD mRNA

NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704

G

BAG cochaperone 1

affects expression

Cocaine affects the expression of BAG1 mRNA

NCBI chr 9:33,252,471...33,264,708
Ensembl chr 9:33,247,820...33,264,720

G

BAG cochaperone 3

affects expression
increases expression

Cocaine affects the expression of BAG3 mRNA
Cocaine results in increased expression of BAG3 mRNA

PMID:15681117 PMID:27899881

NCBI chr10:119,651,380...119,677,819
Ensembl chr10:119,651,380...119,677,819

G

BMP and activin membrane bound inhibitor

affects expression

Cocaine affects the expression of BAMBI mRNA

NCBI chr10:28,677,521...28,682,932
Ensembl chr10:28,677,510...28,682,932

G

brain abundant membrane attached signal protein 1

affects expression

Cocaine affects the expression of BASP1 mRNA

NCBI chr 5:17,216,823...17,276,834
Ensembl chr 5:17,065,598...17,276,843

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions
increases activity
affects expression

Cocaine results in increased expression of BAX mRNA
ADCYAP1 protein modified form affects the reaction [Cocaine results in increased expression of BAX protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [Cocaine results in increased expression of BAX protein]; IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]; TNF protein affects the reaction [Cocaine results in increased expression of BAX protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]]
Cocaine results in increased activity of BAX protein
Cocaine affects the expression of BAX mRNA

PMID:11392460 PMID:15681117 PMID:15685203 PMID:17084983 PMID:17635674 More...

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

bromodomain adjacent to zinc finger domain 1B

increases expression
multiple interactions

Cocaine results in increased expression of BAZ1B mRNA
[SMARCA5 protein co-treated with BAZ1B protein] results in increased susceptibility to Cocaine; Cocaine promotes the reaction [BAZ1B protein binds to SPHKAP gene]; Cocaine results in increased expression of and affects the activity of BAZ1B protein

NCBI chr 7:73,440,406...73,522,293
Ensembl chr 7:73,440,406...73,522,293

G

bromodomain adjacent to zinc finger domain 2B

increases expression

Cocaine results in increased expression of BAZ2B mRNA

NCBI chr 2:159,315,312...159,712,442
Ensembl chr 2:159,318,979...159,616,569

G

B cell receptor associated protein 31

affects expression

Cocaine affects the expression of BCAP31 mRNA

NCBI chr X:153,700,492...153,724,387
Ensembl chr X:153,700,492...153,724,565

G

branched chain amino acid transaminase 1

affects expression

Cocaine affects the expression of BCAT1 mRNA

NCBI chr12:24,810,024...24,949,340
Ensembl chr12:24,810,024...24,949,101

G

butyrylcholinesterase

affects metabolic processing
multiple interactions
increases hydrolysis
increases metabolic processing
decreases response to substance
affects hydrolysis
decreases metabolic processing
affects degradation

BCHE protein affects the metabolism of Cocaine
[BCHE protein mutant form results in increased metabolism of Cocaine] which results in increased chemical synthesis of Benzoic Acid; [BCHE protein mutant form results in increased metabolism of Cocaine] which results in increased chemical synthesis of ecgonine methyl ester
[BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of Benzoic Acid; [BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of ecgonine methyl ester
BCHE protein mutant form results in increased metabolism of Cocaine; BCHE protein results in increased metabolism of Cocaine
BCHE protein mutant form results in decreased susceptibility to Cocaine
BCHE protein modified form results in increased hydrolysis of Cocaine; BCHE protein mutant form results in increased hydrolysis of Cocaine
BCHE protein affects the hydrolysis of Cocaine
BCHE protein mutant form results in decreased metabolism of Cocaine
BCHE protein mutant form affects the degradation of Cocaine

PMID:572161 PMID:16275916 PMID:17989928 PMID:18514178 PMID:18514640 More...

NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462

G

BCL11 transcription factor B

increases expression

Cocaine deficiency results in increased expression of BCL11B mRNA

NCBI chr14:99,169,287...99,272,197
Ensembl chr14:99,169,287...99,272,197

G

BCL2 apoptosis regulator

affects expression
multiple interactions
decreases expression
increases phosphorylation
increases expression

Cocaine affects the expression of BCL2 mRNA
IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; PRKCD protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2 protein]; TNF protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]]
Cocaine results in increased phosphorylation of BCL2 protein
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; 7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; SCH 23390 inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]
Cocaine results in decreased expression of BCL2 mRNA; Cocaine results in decreased expression of BCL2 protein
Cocaine results in increased expression of BCL2 protein

PMID:11392460 PMID:15365088 PMID:15681117 PMID:15685203 PMID:17084983 More...

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

increases expression
decreases expression
multiple interactions

Cocaine results in increased expression of BCL2L1 mRNA; Cocaine results in increased expression of BCL2L1 mRNA alternative form
Cocaine results in decreased expression of BCL2L1 protein
IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; PRKCD protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2L1 protein]; TNF protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]]

PMID:16076954 PMID:29673861 PMID:30393195

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

BCL2 like 11

increases expression

Cocaine results in increased expression of BCL2L11 mRNA

NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444

G

brain derived neurotrophic factor

decreases response to substance
increases expression
decreases activity
affects expression
multiple interactions
decreases expression
increases response to substance

BDNF mRNA results in decreased susceptibility to Cocaine; BDNF protein results in decreased susceptibility to Cocaine
Cocaine results in increased expression of BDNF mRNA
Cocaine results in decreased activity of BDNF protein
Cocaine results in increased expression of BDNF protein
Cocaine affects the expression of BDNF exon; Cocaine affects the expression of BDNF mRNA; Cocaine affects the expression of BDNF protein
BDNF protein inhibits the reaction [Cocaine results in increased abundance of Amino Acids, Peptides, and Proteins]; Cocaine affects the activity of and affects the expression of BDNF protein; Cocaine affects the reaction [CREB1 modified form binds to BDNF promoter]; Cocaine affects the reaction [MECP2 protein affects the expression of BDNF protein]; Cocaine affects the reaction [MECP2 protein binds to and results in decreased activity of BDNF promoter]; Cocaine affects the reaction [MIR212 protein affects the expression of BDNF protein]
BDNF mRNA results in decreased susceptibility to Cocaine; BDNF protein results in decreased susceptibility to Cocaine; BDNF results in decreased susceptibility to Cocaine
(+)-JQ1 compound inhibits the reaction [Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]]; (+)-JQ1 compound inhibits the reaction [Cocaine results in increased expression of BDNF mRNA]; Cocaine inhibits the reaction [CREB1 protein binds to BDNF promoter]; Cocaine inhibits the reaction [MECP2 protein binds to BDNF promoter]; Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of BDNF mRNA]; Haloperidol inhibits the reaction [Cocaine results in decreased expression of BDNF protein]
Cocaine results in decreased expression of BDNF mRNA; Cocaine results in decreased expression of BDNF protein
BDNF results in increased susceptibility to Cocaine

PMID:12099907 PMID:14973246 PMID:16423334 PMID:17194538 PMID:17618281 More...

NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058

G

brain enriched guanylate kinase associated

affects expression

Cocaine affects the expression of BEGAIN mRNA

NCBI chr14:100,537,147...100,587,417
Ensembl chr14:100,537,147...100,587,417

G

basic helix-loop-helix family member e22

increases expression

Cocaine results in increased expression of BHLHE22 mRNA

NCBI chr 8:64,580,365...64,583,627
Ensembl chr 8:64,580,365...64,583,627

G

basic helix-loop-helix family member e40

affects expression

Cocaine affects the expression of BHLHE40 mRNA

NCBI chr 3:4,979,437...4,985,323
Ensembl chr 3:4,979,437...4,985,323

G

BH3 interacting domain death agonist

affects expression

Cocaine affects the expression of BID mRNA

NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770

G

BCL2 interacting killer

affects expression

Cocaine affects the expression of BIK mRNA

NCBI chr22:43,110,750...43,129,712
Ensembl chr22:43,110,750...43,129,712

G

basic helix-loop-helix ARNT like 1

decreases expression

Cocaine results in decreased expression of BMAL1 mRNA

NCBI chr11:13,276,652...13,387,266
Ensembl chr11:13,276,652...13,387,266

G

BMP2 inducible kinase

affects expression

Cocaine affects the expression of BMP2K mRNA

NCBI chr 4:78,776,350...78,916,365
Ensembl chr 4:78,776,342...78,916,365

G

bone morphogenetic protein receptor type 2

increases expression

Cocaine results in increased expression of BMPR2 mRNA

NCBI chr 2:202,376,327...202,567,749
Ensembl chr 2:202,376,327...202,567,751

G

BCL2 interacting protein 2

affects expression

Cocaine affects the expression of BNIP2 mRNA

NCBI chr15:59,659,146...59,689,320
Ensembl chr15:59,659,146...59,689,339

G

BCL2 interacting protein 3

affects expression

Cocaine affects the expression of BNIP3 mRNA

NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967

G

BCL2 interacting protein 3 like

affects expression

Cocaine affects the expression of BNIP3L mRNA

NCBI chr 8:26,383,054...26,413,127
Ensembl chr 8:26,383,054...26,505,636

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bromodomain containing 4

multiple interactions
increases expression

(+)-JQ1 compound inhibits the reaction [Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]]; Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]
Cocaine results in increased expression of BRD4 protein

NCBI chr19:15,235,519...15,332,539
Ensembl chr19:15,235,519...15,332,545

G

BSCL2 lipid droplet biogenesis associated, seipin

affects expression

Cocaine affects the expression of BSCL2 mRNA

NCBI chr11:62,690,262...62,709,537
Ensembl chr11:62,689,289...62,709,845

G

bone marrow stromal cell antigen 1

affects expression

Cocaine affects the expression of BST1 mRNA

NCBI chr 4:15,703,065...15,774,173
Ensembl chr 4:15,703,065...15,738,313

G

BTB domain containing 9

increases expression

Cocaine results in increased expression of BTBD9 mRNA

NCBI chr 6:38,168,451...38,639,929
Ensembl chr 6:38,168,451...38,640,148

G

BTG anti-proliferation factor 2

affects expression

Cocaine affects the expression of BTG2 mRNA

NCBI chr 1:203,305,519...203,309,602
Ensembl chr 1:203,305,491...203,309,602

G

Bruton tyrosine kinase

decreases expression

Cocaine results in decreased expression of BTK mRNA

NCBI chr X:101,349,450...101,390,796
Ensembl chr X:101,349,338...101,390,796

G

chromosome 11 open reading frame 96

increases expression

Cocaine results in increased expression of C3H11ORF96 mRNA

NCBI chr11:43,942,637...43,943,878
Ensembl chr11:43,942,637...43,943,878

G

complement C1q binding protein

decreases expression

Cocaine results in decreased expression of C1QBP protein

NCBI chr17:5,432,777...5,439,155
Ensembl chr17:5,432,777...5,448,830

G

C1q and TNF related 1

affects expression

Cocaine affects the expression of C1QTNF1 mRNA

NCBI chr17:79,022,934...79,049,788
Ensembl chr17:79,022,814...79,049,788

G

C1q and TNF related 4

decreases expression

Cocaine results in decreased expression of C1QTNF4 mRNA

NCBI chr11:47,589,667...47,595,304
Ensembl chr11:47,589,667...47,594,411

G

C2 domain containing 3 centriole elongation regulator

decreases expression

Cocaine results in decreased expression of C2CD3 mRNA

NCBI chr11:74,012,718...74,171,002
Ensembl chr11:74,012,718...74,171,210

G

C2 calcium dependent domain containing 4D

decreases expression

Cocaine results in decreased expression of C2CD4D mRNA

NCBI chr 1:151,837,818...151,840,557
Ensembl chr 1:151,837,818...151,840,557

G

carbonic anhydrase 4

decreases expression

Cocaine results in decreased expression of CAR4 mRNA

NCBI chr17:60,149,973...60,179,021
Ensembl chr17:60,149,942...60,170,899

G

calcium binding protein 39 like

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in increased expression of CAB39L mRNA

NCBI chr13:49,308,650...49,444,064
Ensembl chr13:49,308,650...49,444,064

G

calcium voltage-gated channel subunit alpha1 D

affects response to substance

CACNA1D polymorphism affects the susceptibility to Cocaine

NCBI chr 3:53,494,611...53,813,733
Ensembl chr 3:53,328,963...53,813,733

G

calcium voltage-gated channel auxiliary subunit beta 3

affects expression

Cocaine affects the expression of CACNB3 mRNA

NCBI chr12:48,814,480...48,828,941
Ensembl chr12:48,813,794...48,828,941

G

caldesmon 1

affects expression

Cocaine affects the expression of CALD1 mRNA

NCBI chr 7:134,745,467...134,970,729
Ensembl chr 7:134,744,252...134,970,729

G

calmodulin 1

decreases expression

Cocaine results in decreased expression of CALM1 mRNA

NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268

G

calmodulin 2

decreases expression

Cocaine results in decreased expression of CALM2 mRNA

NCBI chr 2:47,160,082...47,176,936
Ensembl chr 2:47,160,084...47,176,921

G

calreticulin

decreases expression
multiple interactions
affects expression

Cocaine results in decreased expression of CALR mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of CALR mRNA]
Cocaine affects the expression of CALR mRNA

PMID:18355967 PMID:20187946

NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489

G

calcyon neuron specific vesicular protein

increases expression

Cocaine results in increased expression of CALY mRNA

NCBI chr10:133,324,072...133,336,896
Ensembl chr10:133,324,072...133,336,935

G

calcium/calmodulin dependent protein kinase IG

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in increased expression of CAMK1G mRNA

NCBI chr 1:209,583,714...209,613,939
Ensembl chr 1:209,583,714...209,613,939

G

calcium/calmodulin dependent protein kinase II alpha

affects response to substance
multiple interactions
increases expression

CAMK2A affects the susceptibility to Cocaine
Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein; Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein]
Cocaine results in increased expression of CAMK2A protein
7-chlorokynurenic acid inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein]; Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]; Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein; KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]; Sodium Benzoate promotes the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein]

PMID:14725635 PMID:17609678 PMID:19217379 PMID:28194001

NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093

G

calcium/calmodulin dependent protein kinase II beta

decreases expression
affects expression

Cocaine results in decreased expression of CAMK2B mRNA
Cocaine affects the expression of CAMK2B mRNA

PMID:17205118 PMID:20187946

NCBI chr 7:44,217,154...44,326,013
Ensembl chr 7:44,210,019...44,334,577

G

calcium/calmodulin dependent protein kinase IV

increases response to substance
decreases response to substance

CAMK4 promoter SNP results in increased susceptibility to Cocaine
CAMK4 protein results in decreased susceptibility to Cocaine

NCBI chr 5:111,223,583...111,494,886
Ensembl chr 5:111,223,653...111,494,886

G

cyclase associated actin cytoskeleton regulatory protein 2

affects expression

Cocaine affects the expression of CAP2 mRNA

NCBI chr 6:17,393,595...17,557,780
Ensembl chr 6:17,393,595...17,557,780

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capping actin protein of muscle Z-line subunit beta

decreases expression

Cocaine results in decreased expression of CAPZB mRNA

NCBI chr 1:19,338,775...19,485,539
Ensembl chr 1:19,338,775...19,485,539

G

caspase recruitment domain family member 11

decreases expression

Cocaine results in decreased expression of CARD11 mRNA

NCBI chr 7:2,906,142...3,043,867
Ensembl chr 7:2,906,142...3,044,228

G

coactivator associated arginine methyltransferase 1

affects expression

Cocaine affects the expression of CARM1 mRNA

NCBI chr19:10,871,553...10,923,075
Ensembl chr19:10,871,553...10,923,075

G

carnosine N-methyltransferase 1

affects expression

Cocaine affects the expression of CARNMT1 mRNA

NCBI chr 9:74,980,790...75,028,430
Ensembl chr 9:74,980,790...75,028,423

G

CART prepropeptide

increases expression
affects expression

Cocaine results in increased expression of CARTPT mRNA
Cocaine affects the expression of CARTPT mRNA

PMID:15009677 PMID:17851536 PMID:20187946

NCBI chr 5:71,719,275...71,721,045
Ensembl chr 5:71,719,275...71,721,048

G

caspase 2

increases activity
increases expression

Cocaine results in increased activity of CASP2 protein
Cocaine results in increased expression of CASP2 mRNA

PMID:16076954 PMID:16638611

NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696

G

caspase 3

increases expression
increases cleavage
multiple interactions
increases activity
affects expression

Cocaine results in increased expression of CASP3 protein
Cocaine results in increased cleavage of CASP3 protein
ADCYAP1 protein modified form affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; GPX1 affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; PRKCD protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [Cocaine results in increased cleavage of CASP3 protein]; TNF protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]]
Cocaine results in increased activity of CASP3 protein
Cocaine affects the expression of CASP3 protein
[Heroin co-treated with Cocaine] results in increased activity of CASP3 protein; Cocaine results in increased cleavage of and results in increased activity of CASP3 protein; Heroin promotes the reaction [Cocaine results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Cocaine results in increased activity of CASP3 protein]
Cocaine affects the expression of CASP3 mRNA

PMID:10604926 PMID:11392460 PMID:12639677 PMID:14741756 PMID:15365088 More...

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 4

affects expression
decreases expression

Cocaine affects the expression of CASP4 mRNA
Cocaine results in decreased expression of CASP4 mRNA

PMID:12629581 PMID:15681117

NCBI chr11:104,942,866...104,968,574
Ensembl chr11:104,942,866...104,969,366

G

caspase 8

affects expression
increases activity

Cocaine affects the expression of CASP8 mRNA
Cocaine results in increased activity of CASP8 protein

PMID:11392460 PMID:15681117 PMID:18974856

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

affects expression
increases activity
multiple interactions
increases expression

Cocaine affects the expression of CASP9 mRNA
Cocaine results in increased activity of CASP9 protein
SB 203580 inhibits the reaction [Cocaine results in increased activity of CASP9 protein]
Cocaine affects the expression of CASP9 protein
Cocaine results in increased expression of CASP9 protein

PMID:10604926 PMID:11392460 PMID:12639677 PMID:15365088 PMID:15681117 More...

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

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cytosolic arginine sensor for mTORC1 subunit 1

affects expression

Cocaine affects the expression of CASTOR1 mRNA

NCBI chr22:30,285,117...30,289,505
Ensembl chr22:30,285,117...30,289,622

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catalase

decreases activity
increases activity
increases expression

Cocaine results in decreased activity of CAT protein
Cocaine results in increased activity of CAT protein
Cocaine results in increased expression of CAT protein

PMID:14576513 PMID:16085363 PMID:29475069

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

cation channel sperm associated 2

increases expression

Cocaine results in increased expression of CATSPER2 mRNA

NCBI chr15:43,628,503...43,648,884
Ensembl chr15:43,628,503...43,668,118

G

cerebellin 1 precursor

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in increased expression of CBLN1 mRNA

NCBI chr16:49,277,917...49,281,838
Ensembl chr16:49,277,917...49,281,838

G

coiled-coil domain containing 127

increases expression

Cocaine results in increased expression of CCDC127 mRNA

NCBI chr 5:196,868...218,153
Ensembl chr 5:196,868...218,153

G

coiled-coil domain containing 174

affects expression

Cocaine affects the expression of CCDC174 mRNA

NCBI chr 3:14,651,762...14,672,655
Ensembl chr 3:14,651,762...14,672,659

G

coiled-coil domain containing 73

decreases expression

Cocaine results in decreased expression of CCDC73 mRNA

NCBI chr11:32,602,721...32,830,585
Ensembl chr11:32,602,721...32,794,662

G

coiled-coil domain containing 88A

increases expression

Cocaine results in increased expression of CCDC88A mRNA

NCBI chr 2:55,287,842...55,419,856
Ensembl chr 2:55,287,842...55,419,895

G

coiled-coil domain containing 93

increases expression

Cocaine results in increased expression of CCDC93 mRNA

NCBI chr 2:117,915,481...118,014,070
Ensembl chr 2:117,915,478...118,014,133

G

cholecystokinin B receptor

decreases expression
increases response to substance

Cocaine results in decreased expression of CCKBR mRNA
CCKBR protein results in increased susceptibility to Cocaine

PMID:11403953 PMID:18000554

NCBI chr11:6,259,838...6,272,127
Ensembl chr11:6,259,806...6,272,127

G

C-C motif chemokine ligand 2

increases secretion
increases expression
multiple interactions

Cocaine results in increased secretion of CCL2 protein
Cocaine results in increased expression of CCL2 protein
Cocaine results in increased expression of CCL2 mRNA; Cocaine results in increased expression of CCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; AG 1879 inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; Cocaine promotes the reaction [RELA protein binds to CCL2 promoter]; methyl-beta-cyclodextrin inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; pyrazolanthrone inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; RELA mutant form inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; SC 514 inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; U 0126 inhibits the reaction [Cocaine results in increased expression of CCL2 protein]

PMID:10065903 PMID:20354174

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

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C-C motif chemokine ligand 3

increases secretion

Cocaine results in increased secretion of CCL3 protein

NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169

G

cellular communication network factor 2

decreases expression

Cocaine results in decreased expression of CCN2 mRNA; Cocaine results in decreased expression of CCN2 protein

NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372

G

cellular communication network factor 3

increases expression

Cocaine results in increased expression of CCN3 mRNA

NCBI chr 8:119,416,446...119,424,434
Ensembl chr 8:119,416,446...119,424,434

G

cyclin A2

decreases expression

Cocaine results in decreased expression of CCNA2 mRNA

NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883

G

cyclin D1

affects expression

Cocaine affects the expression of CCND1 mRNA

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cyclin D3

affects expression

Cocaine affects the expression of CCND3 mRNA

NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357

G

cyclin L1

increases expression

Cocaine results in increased expression of CCNL1 mRNA

NCBI chr 3:157,143,121...157,160,147
Ensembl chr 3:157,146,508...157,160,760

G

C-C motif chemokine receptor 2

increases response to substance
affects expression

CCR2 results in increased susceptibility to Cocaine
Cocaine affects the expression of CCR2 mRNA

PMID:20187946 PMID:20354174

NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940

G

C-C motif chemokine receptor 5

increases expression

Cocaine results in increased expression of CCR5 protein

NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,946...46,376,206

G

coiled-coil serine rich protein 1

affects response to substance

CCSER1 gene SNP affects the susceptibility to Cocaine

NCBI chr 4:90,127,394...91,605,295
Ensembl chr 4:90,127,394...91,605,295

G

chaperonin containing TCP1 subunit 2

affects expression

Cocaine affects the expression of CCT2 mRNA

NCBI chr12:69,585,459...69,601,570
Ensembl chr12:69,585,426...69,601,570

G

CCZ1 homolog, vacuolar protein trafficking and biogenesis associated

decreases expression

Cocaine results in decreased expression of CCZ1 mRNA

NCBI chr 7:5,898,733...5,926,550
Ensembl chr 7:5,898,725...5,926,550

G

CD180 molecule

decreases expression

Cocaine results in decreased expression of CD180 mRNA

NCBI chr 5:67,179,613...67,196,799
Ensembl chr 5:67,179,613...67,196,799

G

CD276 molecule

affects expression

Cocaine affects the expression of CD276 mRNA

NCBI chr15:73,683,944...73,714,514
Ensembl chr15:73,683,966...73,714,514

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CD4 molecule

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of CD4 mRNA

NCBI chr12:6,789,528...6,820,799
Ensembl chr12:6,786,858...6,820,799

G

CD44 molecule (IN blood group)

decreases expression

Cocaine results in decreased expression of CD44 mRNA

NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402

G

CD47 molecule

affects expression

Cocaine affects the expression of CD47 mRNA

NCBI chr 3:108,043,091...108,091,031
Ensembl chr 3:108,043,091...108,091,862

G

CD74 molecule

affects expression

Cocaine affects the expression of CD74 mRNA

NCBI chr 5:150,401,639...150,412,910
Ensembl chr 5:150,401,637...150,412,969

G

CD81 molecule

increases response to substance
increases expression
affects response to substance

CD81 protein results in increased susceptibility to Cocaine
Cocaine results in increased expression of CD81 mRNA
CD81 protein affects the susceptibility to Cocaine

PMID:11178868 PMID:12113778 PMID:15715673

NCBI chr11:2,376,180...2,397,397
Ensembl chr11:2,376,177...2,397,802

G

CD93 molecule

decreases expression

Cocaine results in decreased expression of CD93 mRNA

NCBI chr20:23,079,360...23,086,324
Ensembl chr20:23,079,360...23,086,324

G

cell division cycle 14B

decreases expression

Cocaine results in decreased expression of CDC14B mRNA

NCBI chr 9:96,490,939...96,619,843
Ensembl chr 9:96,490,241...96,619,843

G

cell division cycle 25A

increases expression

Cocaine results in increased expression of CDC25A mRNA

NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417

G

cadherin 1

decreases expression

Cocaine results in decreased expression of CDH1 mRNA

NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537

G

cadherin 16

affects expression

Cocaine affects the expression of CDH16 mRNA

NCBI chr16:66,908,122...66,918,885
Ensembl chr16:66,908,122...66,918,917

G

cadherin 17

decreases expression

Cocaine results in decreased expression of CDH17 mRNA

NCBI chr 8:94,127,162...94,217,278
Ensembl chr 8:94,127,162...94,217,303

G

cyclin dependent kinase 18

affects expression

Cocaine affects the expression of CDK18 mRNA

NCBI chr 1:205,504,669...205,532,790
Ensembl chr 1:205,504,596...205,532,793

G

cyclin dependent kinase 4

affects expression

Cocaine affects the expression of CDK4 mRNA

NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013

G

cyclin dependent kinase 5

affects expression
increases expression
decreases expression

Cocaine affects the expression of CDK5 mRNA; Cocaine affects the expression of CDK5 protein
Cocaine results in increased expression of CDK5 mRNA; Cocaine results in increased expression of CDK5 protein
Cocaine results in decreased expression of CDK5 protein

PMID:11268215 PMID:12787079 PMID:16263094 PMID:17339080 PMID:17680995 More...

NCBI chr 7:151,053,815...151,057,897
Ensembl chr 7:151,053,815...151,057,897

G

cyclin dependent kinase 5 regulatory subunit 1

multiple interactions
increases expression
decreases expression

CDK5R1 protein inhibits the reaction [Cocaine affects the expression of FOS mRNA]; CDK5R1 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K1 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K2 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAPK1 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAPK3 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]
Cocaine results in increased expression of CDK5R1 mRNA; Cocaine results in increased expression of CDK5R1 protein
Cocaine results in decreased expression of CDK5R1 protein

PMID:11268215 PMID:15665076 PMID:16263094

NCBI chr17:32,486,993...32,491,253
Ensembl chr17:32,486,993...32,491,253

G

cyclin dependent kinase inhibitor 1A

increases expression

Cocaine results in increased expression of CDKN1A mRNA

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337

G

CEA cell adhesion molecule 1

affects expression

Cocaine affects the expression of CEACAM3 mRNA

NCBI chr19:42,507,306...42,528,481
Ensembl chr19:42,507,304...42,561,234

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carboxyl ester lipase

increases expression

Cocaine results in increased expression of CEL mRNA

NCBI chr 9:133,061,981...133,071,861
Ensembl chr 9:133,061,981...133,071,861

G

carboxylesterase 1

multiple interactions
increases hydrolysis
affects binding

CES1 protein results in increased metabolism of [Cocaine co-treated with Ethanol]; Cocaine inhibits the reaction [CES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]
CES1 protein results in increased hydrolysis of Cocaine
Cocaine binds to CES1 protein

PMID:8930175 PMID:9311626 PMID:12679808 PMID:12773168 PMID:25445008

NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337

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carboxylesterase 2

multiple interactions
decreases expression
increases hydrolysis

Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]; Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of Morphine]; Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of 6-O-monoacetylmorphine]; Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of Heroin]
Cocaine results in decreased expression of CES2 mRNA
CES2 protein results in increased hydrolysis of Cocaine

PMID:8930175 PMID:9169443 PMID:12629581

NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096

G

complement factor H

decreases expression

Cocaine results in decreased expression of CFH mRNA

NCBI chr 1:196,652,043...196,747,504
Ensembl chr 1:196,651,754...196,752,476

G

CASP8 and FADD like apoptosis regulator

affects expression

Cocaine affects the expression of CFLAR mRNA

NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687

G

choline O-acetyltransferase

increases expression

Cocaine results in increased expression of CHAT protein

NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942

G

checkpoint with forkhead and ring finger domains

affects expression

Cocaine affects the expression of CHFR mRNA

NCBI chr12:132,832,356...132,887,618
Ensembl chr12:132,822,187...132,956,304

G

chimerin 1

affects expression

Cocaine affects the expression of CHN1 mRNA

NCBI chr 2:174,798,809...175,005,381
Ensembl chr 2:174,798,809...175,005,381

G

cholinergic receptor muscarinic 1

increases expression

Cocaine results in increased expression of CHRM1 protein

NCBI chr11:62,908,679...62,921,878
Ensembl chr11:62,908,679...62,921,807

G

cholinergic receptor muscarinic 3

increases expression

Cocaine results in increased expression of CHRM3 protein

NCBI chr 1:239,386,568...239,915,450
Ensembl chr 1:239,386,565...239,915,452

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cholinergic receptor muscarinic 4

affects expression

Cocaine affects the expression of CHRM4 mRNA

NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,383,789...46,391,776

G

cholinergic receptor muscarinic 5

decreases response to substance
increases expression

CHRM5 mutant form results in decreased susceptibility to Cocaine
Cocaine results in increased expression of CHRM5 protein

PMID:20393457 PMID:35597300

NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]

NCBI chr15:78,593,052...78,620,996
Ensembl chr15:78,593,052...78,621,295

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr20:63,343,223...63,361,349
Ensembl chr20:63,343,223...63,378,401

G

cholinergic receptor nicotinic alpha 5 subunit

decreases response to substance

CHRNA5 gene polymorphism results in decreased susceptibility to Cocaine

NCBI chr15:78,565,520...78,595,269
Ensembl chr15:78,565,520...78,595,269

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions
increases response to substance

Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
CHRNB2 protein results in increased susceptibility to Cocaine

PMID:10336510 PMID:11282258

NCBI chr 1:154,567,778...154,580,013
Ensembl chr 1:154,567,778...154,580,013

G

cholinergic receptor nicotinic epsilon subunit

increases expression

Cocaine results in increased expression of CHRNE mRNA

NCBI chr17:4,897,771...4,908,677
Ensembl chr17:4,897,771...4,934,438

G

chromosome transmission fidelity factor 8

decreases expression

Cocaine results in decreased expression of CHTF8 mRNA

NCBI chr16:69,118,010...69,132,588
Ensembl chr16:69,118,010...69,132,588

G

churchill domain containing 1

decreases expression

Cocaine results in decreased expression of CHURC1 mRNA

PMID:15009677 PMID:16710320

NCBI chr14:64,914,455...64,935,368
Ensembl chr14:64,914,361...64,944,591

G

cytosolic iron-sulfur assembly component 1

affects expression

Cocaine affects the expression of CIAO1 mRNA

NCBI chr 2:96,266,225...96,274,173
Ensembl chr 2:96,266,159...96,274,173

G

cell death inducing DFFA like effector a

affects expression

Cocaine affects the expression of CIDEA mRNA

NCBI chr18:12,254,361...12,277,595
Ensembl chr18:12,254,361...12,277,595

G

cell death inducing DFFA like effector b

affects expression

Cocaine affects the expression of CIDEB mRNA

NCBI chr14:24,305,187...24,311,435
Ensembl chr14:24,305,187...24,311,430

G

CDGSH iron sulfur domain 1

increases expression

Cocaine results in increased expression of CISD1 protein

NCBI chr10:58,269,162...58,289,586
Ensembl chr10:58,269,162...58,289,586

G

CDGSH iron sulfur domain 2

increases expression

Cocaine results in increased expression of CISD2 mRNA

NCBI chr 4:102,868,992...102,892,807
Ensembl chr 4:102,868,974...102,892,807

G

Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4

decreases expression

Cocaine results in decreased expression of CITED4 mRNA

NCBI chr 1:40,861,054...40,862,363
Ensembl chr 1:40,861,054...40,862,363

G

creatine kinase B

multiple interactions

Cocaine results in increased secretion of [CKB protein binds to CKM protein]

NCBI chr14:103,519,667...103,522,830
Ensembl chr14:103,519,667...103,522,833

G

creatine kinase, M-type

multiple interactions

Cocaine results in increased secretion of [CKB protein binds to CKM protein]

NCBI chr19:45,306,413...45,322,875
Ensembl chr19:45,306,413...45,322,875

G

creatine kinase, mitochondrial 1B

affects expression

Cocaine affects the expression of CKMT1 mRNA

NCBI chr15:43,592,857...43,599,406
Ensembl chr15:43,593,054...43,604,901
Ensembl chr15:43,593,054...43,604,901

G

chloride voltage-gated channel 7

affects expression

Cocaine affects the expression of CLCN7 mRNA

NCBI chr16:1,444,935...1,475,028
Ensembl chr16:1,444,934...1,475,077

G

claudin 11

decreases expression

Cocaine results in decreased expression of CLDN11 mRNA

NCBI chr 3:170,418,868...170,434,691
Ensembl chr 3:170,418,868...170,454,733

G

C-type lectin domain family 4 member F

affects expression

Cocaine affects the expression of CLEC4F mRNA

NCBI chr 2:70,808,643...70,825,235
Ensembl chr 2:70,808,643...70,820,599

G

chloride intracellular channel 1

decreases expression

Cocaine results in decreased expression of CLIC1 mRNA

NCBI chr 6:31,730,581...31,737,318
Ensembl chr 6:31,730,581...31,739,763

G

CAP-Gly domain containing linker protein 1

increases expression

Cocaine results in increased expression of CLIP1 mRNA

NCBI chr12:122,271,469...122,422,956
Ensembl chr12:122,271,432...122,422,669

G

CDC like kinase 1

increases expression
multiple interactions

Cocaine results in increased expression of CLK1 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of CLK1 mRNA]

NCBI chr 2:200,853,009...200,864,658
Ensembl chr 2:200,853,009...200,864,691

G

CDC like kinase 4

increases expression

Cocaine results in increased expression of CLK4 mRNA

NCBI chr 5:178,602,664...178,627,050
Ensembl chr 5:178,602,664...178,630,615

G

clock circadian regulator

increases expression

Cocaine results in increased expression of CLOCK mRNA

NCBI chr 4:55,427,903...55,546,909
Ensembl chr 4:55,427,903...55,546,909

G

clathrin light chain B

decreases expression

Cocaine results in decreased expression of CLTB mRNA

PMID:12629581 PMID:15009677

NCBI chr 5:176,392,455...176,416,569
Ensembl chr 5:176,392,501...176,416,539

G

citramalyl-CoA lyase

increases expression

Cocaine results in increased expression of CLYBL protein

NCBI chr13:99,606,690...99,909,444
Ensembl chr13:99,606,669...99,909,459

G

cyclic nucleotide binding domain containing 2

increases expression

Cocaine results in increased expression of CNBD2 mRNA

NCBI chr20:35,954,386...36,030,700
Ensembl chr20:35,954,564...36,030,700

G

connector enhancer of kinase suppressor of Ras 2

increases expression

Cocaine results in increased expression of CNKSR2 mRNA

NCBI chr X:21,374,418...21,654,689
Ensembl chr X:21,372,801...21,654,695

G

cannabinoid receptor 1

affects response to substance
increases activity
decreases response to substance
multiple interactions

CNR1 gene polymorphism affects the susceptibility to Cocaine; CNR1 gene SNP affects the susceptibility to Cocaine; CNR1 polymorphism affects the susceptibility to Cocaine
Cocaine results in increased activity of CNR1 protein
CNR1 mutant form results in decreased susceptibility to Cocaine
CNR1 gene mutant form inhibits the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased expression of FOS protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:9106242 PMID:16314880 PMID:17596442 PMID:19052543 PMID:20554863

NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347

G

cannabinoid receptor 2

increases expression

Cocaine results in increased expression of CNR2 mRNA

NCBI chr 1:23,870,515...23,913,362
Ensembl chr 1:23,870,515...23,913,362

G

cordon-bleu WH2 repeat protein like 1

increases expression

Cocaine results in increased expression of COBLL1 mRNA

NCBI chr 2:164,657,931...164,842,076
Ensembl chr 2:164,653,624...164,843,679

G

coilin

affects expression

Cocaine affects the expression of COIL mRNA

NCBI chr17:56,938,199...56,961,050
Ensembl chr17:56,938,199...56,961,050

G

collagen type XV alpha 1 chain

affects expression

Cocaine affects the expression of COL15A1 mRNA

NCBI chr 9:98,943,907...99,070,787
Ensembl chr 9:98,943,179...99,070,787

G

collagen type I alpha 1 chain

increases expression

Cocaine results in increased expression of COL1A1 mRNA

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

G

collagen type XXI alpha 1 chain

affects response to substance

COL21A1 gene SNP affects the susceptibility to Cocaine

NCBI chr 6:56,056,590...56,394,128
Ensembl chr 6:56,056,590...56,394,094

G

collagen type III alpha 1 chain

increases expression

Cocaine results in increased expression of COL3A1 mRNA

NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746

G

coenzyme Q6, monooxygenase

affects expression

Cocaine affects the expression of COQ6 mRNA

NCBI chr14:73,949,926...73,963,670
Ensembl chr14:73,949,926...73,963,670

G

coronin 7

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of CORO7 mRNA

NCBI chr16:4,354,542...4,416,596
Ensembl chr16:4,354,542...4,425,705

G

cytochrome c oxidase assembly factor COX20

decreases expression

Cocaine results in decreased expression of COX20 mRNA

NCBI chr 1:244,835,306...244,845,063
Ensembl chr 1:244,835,616...244,845,057

G

cytochrome c oxidase subunit 5A

affects expression

Cocaine affects the expression of COX5A mRNA

NCBI chr15:74,919,791...74,938,073
Ensembl chr15:74,919,791...74,938,083

G

cytochrome c oxidase subunit 6A1

affects expression
increases expression

Cocaine affects the expression of COX6A1 mRNA
Cocaine results in increased expression of COX6A1 protein

PMID:20187946 PMID:25100957

NCBI chr12:120,438,113...120,440,730
Ensembl chr12:120,438,090...120,440,737

G

cytochrome c oxidase subunit 6C

decreases expression

Cocaine results in decreased expression of COX6C mRNA

NCBI chr 8:99,877,865...99,893,707
Ensembl chr 8:99,873,200...99,893,707

G

cytochrome c oxidase subunit 7B

affects expression

Cocaine affects the expression of COX7B mRNA

NCBI chr X:77,899,468...77,907,376
Ensembl chr X:77,899,440...77,907,376

G

cytochrome c oxidase subunit 8A

affects expression

Cocaine affects the expression of COX8A mRNA

NCBI chr11:63,974,620...63,976,543
Ensembl chr11:63,974,620...63,976,543

G

complexin 1

affects expression

Cocaine affects the expression of CPLX1 mRNA

NCBI chr 4:784,957...826,129
Ensembl chr 4:784,957...826,129

G

copine 8

increases expression

Cocaine results in increased expression of CPNE8 mRNA

NCBI chr12:38,652,203...38,906,835
Ensembl chr12:38,646,822...38,907,430

G

cAMP responsive element binding protein 1

affects expression
increases phosphorylation
multiple interactions
affects phosphorylation
increases expression

Cocaine affects the expression of CREB1 mRNA
cocaine increases phosphorylation of Creb1 protein in nucleus accumbens
Cocaine results in increased phosphorylation of CREB1 protein
CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]; Cocaine inhibits the reaction [CREB1 protein binds to BDNF promoter]; N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of CREB1 protein]; RPS6KA3 gene mutant form inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]
Cocaine affects the phosphorylation of CREB1 protein
Betaxolol affects the reaction [Cocaine affects the phosphorylation of CREB1 protein]; Cocaine affects the reaction [CREB1 modified form binds to BDNF promoter]; Cocaine promotes the reaction [RPS6KA1 protein binds to CREB1 protein]; Cocaine results in increased phosphorylation of and results in increased activity of CREB1 protein; U 0126 inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]

CTD
RGD

PMID:12595601 PMID:15470197 PMID:15665076 PMID:16219028 PMID:16339038 More...

NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988

G

CREB binding protein

increases expression

Cocaine results in increased expression of CREBBP mRNA

NCBI chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713

G

CREB3 regulatory factor

increases expression

Cocaine results in increased expression of CREBRF mRNA

NCBI chr 5:173,056,352...173,139,284
Ensembl chr 5:173,056,352...173,139,284

G

cAMP responsive element modulator

affects expression
increases expression

Cocaine affects the expression of CREM mRNA
Cocaine results in increased expression of CREM mRNA

PMID:18355967 PMID:27899881

NCBI chr10:35,126,846...35,212,958
Ensembl chr10:35,126,791...35,212,958

G

corticotropin releasing hormone

multiple interactions
affects expression

Betaxolol affects the reaction [Cocaine affects the expression of CRH mRNA]; Cocaine affects the reaction [CRH protein affects the secretion of Excitatory Amino Acid Agents]; SCH 23390 affects the reaction [Cocaine affects the expression of CRH mRNA]
Cocaine affects the expression of CRH mRNA; Cocaine affects the expression of CRH protein

PMID:7796157 PMID:11597771 PMID:12782395 PMID:15930388 PMID:18596687

NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464

G

corticotropin releasing hormone binding protein

increases expression

Cocaine results in increased expression of CRHBP mRNA

NCBI chr 5:76,953,045...76,981,159
Ensembl chr 5:76,953,045...76,981,158

G

corticotropin releasing hormone receptor 1

increases expression

Cocaine results in increased expression of CRHR1 protein

NCBI chr17:45,784,320...45,835,828
Ensembl chr17:45,784,277...45,835,828

G

cysteine rich protein 2

affects expression

Cocaine affects the expression of CRIP2 mRNA

NCBI chr14:105,472,945...105,480,170
Ensembl chr14:105,472,962...105,480,162

G

cysteine rich secretory protein LCCL domain containing 1

decreases expression

Cocaine results in decreased expression of CRISPLD1 mRNA

NCBI chr 8:74,984,505...75,034,558
Ensembl chr 8:74,984,505...75,034,558

G

C-reactive protein

increases expression

Cocaine results in increased expression of CRP protein

NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589

G

cartilage acidic protein 1

affects expression

Cocaine affects the expression of CRTAC1 mRNA

NCBI chr10:97,865,000...98,030,621
Ensembl chr10:97,865,000...98,030,828

G

CREB regulated transcription coactivator 1

multiple interactions

[[Cocaine results in increased expression of MIR212 mRNA] which results in increased activity of RAF1 protein] which results in increased expression of CRTC1 protein

NCBI chr19:18,683,680...18,782,333
Ensembl chr19:18,683,678...18,782,333

G

cryptochrome circadian regulator 1

decreases expression

Cocaine results in decreased expression of CRY1 mRNA

NCBI chr12:106,991,364...107,093,549
Ensembl chr12:106,991,364...107,093,549

G

cryptochrome circadian regulator 2

decreases expression

Cocaine results in decreased expression of CRY2 mRNA

NCBI chr11:45,847,118...45,883,244
Ensembl chr11:45,847,118...45,883,248

G

crystallin alpha B

decreases expression
increases expression

Cocaine results in decreased expression of CRYAB mRNA
Cocaine results in increased expression of CRYAB mRNA

PMID:15009677 PMID:27899881

NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722

G

crystallin beta B2

decreases expression

Cocaine results in decreased expression of CRYBB2 mRNA

NCBI chr22:25,211,661...25,231,869
Ensembl chr22:25,212,564...25,231,870

G

cysteine sulfinic acid decarboxylase

affects expression
decreases expression

Cocaine affects the expression of CSAD mRNA
Cocaine results in decreased expression of CSAD protein

PMID:20187946 PMID:25100957

NCBI chr12:53,157,663...53,181,351
Ensembl chr12:53,157,663...53,180,925

G

colony stimulating factor 2 receptor subunit alpha

decreases expression

Cocaine results in decreased expression of CSF2RA mRNA

NCBI chr  X:1,268,814...1,325,218
NCBI chr  Y:1,268,814...1,325,218
Ensembl chr  Y:1,268,800...1,310,381
Ensembl chr  X:1,268,800...1,310,381

G

casein kappa

affects expression

Cocaine affects the expression of CSN3 mRNA

NCBI chr 4:70,238,381...70,251,432
Ensembl chr 4:70,238,382...70,251,474

G

casein kinase 2 alpha 1

decreases expression

Cocaine results in decreased expression of CSNK2A1 mRNA

NCBI chr20:472,498...543,790
Ensembl chr20:472,498...543,835

G

chondroitin sulfate proteoglycan 5

affects expression

Cocaine affects the expression of CSPG5 mRNA; Cocaine affects the expression of CSPG5 protein

NCBI chr 3:47,562,238...47,580,240
Ensembl chr 3:47,562,238...47,580,792

G

cysteine and glycine rich protein 2

decreases expression

Cocaine results in decreased expression of CSRP2 mRNA

NCBI chr12:76,858,709...76,879,019
Ensembl chr12:76,858,709...76,879,023

G

CTD nuclear envelope phosphatase 1

affects expression

Cocaine affects the expression of CTDNEP1 mRNA

NCBI chr17:7,243,591...7,251,978
Ensembl chr17:7,243,591...7,252,491

G

catenin beta 1

affects expression
multiple interactions

Cocaine affects the expression of CTNNB1 mRNA
Cocaine deficiency promotes the reaction [SMARCA4 protein binds to CTNNB1 promoter]

PMID:20187946 PMID:27422367

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

G

catenin beta interacting protein 1

decreases expression

Cocaine results in decreased expression of CTNNBIP1 mRNA

NCBI chr 1:9,848,276...9,910,269
Ensembl chr 1:9,848,276...9,910,336

G

catenin delta 2

decreases expression
increases expression

Cocaine results in decreased expression of CTNND2 mRNA
Cocaine results in increased expression of CTNND2 mRNA

PMID:12629581 PMID:16076954

NCBI chr 5:10,971,836...11,904,446
Ensembl chr 5:10,971,836...11,904,446

G

chymotrypsin like

affects expression
increases expression

Cocaine affects the expression of CTRL mRNA
Cocaine results in increased expression of CTRL mRNA

PMID:20187946 PMID:27899881

NCBI chr16:67,929,574...67,931,862
Ensembl chr16:67,927,640...67,932,365

G

cathepsin B

affects expression
multiple interactions
increases expression

Cocaine affects the expression of CTSB mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of CTSB mRNA]

PMID:15681117 PMID:18355967

NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533

G

cathepsin D

affects expression
increases expression

Cocaine affects the expression of CTSD mRNA
Cocaine results in increased expression of CTSD protein

PMID:15681117 PMID:25100957

NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573

G

CUE domain containing 1

multiple interactions

HDAC5 affects the reaction [Cocaine affects the expression of CUEDC1 mRNA]

NCBI chr17:57,861,243...57,955,412
Ensembl chr17:57,861,243...57,955,412

G

cullin 4B

increases expression

Cocaine results in increased expression of CUL4B mRNA

NCBI chr X:120,523,858...120,575,532
Ensembl chr X:120,505,920...120,604,074

G

CWF19 like cell cycle control factor 2

increases expression

Cocaine results in increased expression of CWF19L2 mRNA

NCBI chr11:107,326,360...107,457,825
Ensembl chr11:107,326,360...107,457,825

G

C-X3-C motif chemokine ligand 1

increases expression

Cocaine results in increased expression of CX3CL1 mRNA

NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044

G

C-X-C motif chemokine ligand 10

increases secretion

Cocaine results in increased secretion of CXCL10 protein

NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497

G

C-X-C motif chemokine ligand 8

increases secretion

Cocaine results in increased secretion of CXCL8 protein

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

C-X-C motif chemokine ligand 9

decreases expression

Cocaine results in decreased expression of CXCL9 mRNA

NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509

G

C-X-C motif chemokine receptor 4

increases expression

Cocaine results in increased expression of CXCR4 protein

NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177

G

CXXC finger protein 5

affects expression

Cocaine affects the expression of CXXC5 mRNA

NCBI chr 5:139,647,299...139,683,882
Ensembl chr 5:139,647,299...139,683,882

G

cytochrome b-245 alpha chain

increases expression

Cocaine results in increased expression of CYBA protein

NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083

G

cytochrome b-245 beta chain

increases expression
increases response to substance

Cocaine results in increased expression of CYBB protein
CYBB results in increased susceptibility to Cocaine

NCBI chr X:37,780,059...37,813,461
Ensembl chr X:37,780,018...37,813,461

G

cytochrome c1

decreases expression

Cocaine results in decreased expression of CYC1 mRNA

NCBI chr 8:144,095,076...144,097,525
Ensembl chr 8:144,095,039...144,097,525

G

cytochrome c, somatic

affects expression
multiple interactions

Cocaine affects the expression of CYCS mRNA
Minocycline inhibits the reaction [Cocaine results in increased secretion of CYCS protein]

PMID:15681117 PMID:21424555

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

cytoglobin

decreases expression

Cocaine results in decreased expression of CYGB protein

NCBI chr17:76,527,356...76,551,193
Ensembl chr17:76,527,356...76,551,175

G

cytochrome P450 family 19 subfamily A member 1

decreases expression

Cocaine results in decreased expression of CYP19A1 mRNA

NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601

G

cytochrome P450 family 1 subfamily A member 1

multiple interactions
increases expression

Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein]; Metyrapone inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein]

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 26 subfamily A member 1

affects expression

Cocaine affects the expression of CYP26A1 mRNA

NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885

G

cytochrome P450 family 26 subfamily B member 1

decreases response to substance

CYP26B1 protein results in decreased susceptibility to Cocaine

NCBI chr 2:72,129,238...72,147,862
Ensembl chr 2:72,129,238...72,147,862

G

cytochrome P450 family 2 subfamily C member 8

decreases expression

Cocaine results in decreased expression of CYP2C8 mRNA; Cocaine results in decreased expression of CYP2C8 protein

NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497

G

cytochrome P450 family 2 subfamily C member 9

decreases expression

Cocaine results in decreased expression of CYP2C9 mRNA; Cocaine results in decreased expression of CYP2C9 protein

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 2 subfamily J member 2

increases expression
multiple interactions

Cocaine results in increased expression of CYP2J2 protein
Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein]; Metyrapone inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein]

NCBI chr 1:59,893,308...59,969,212
Ensembl chr 1:59,893,308...59,926,773

G

cytochrome P450 family 51 subfamily A member 1

decreases expression

Cocaine results in decreased expression of CYP51 mRNA

NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,084,987...92,134,803

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DAB2 interacting protein

decreases expression

Cocaine results in decreased expression of DAB2IP mRNA

NCBI chr 9:121,567,074...121,785,530
Ensembl chr 9:121,567,057...121,785,530

G

DAZ associated protein 1

affects expression

Cocaine affects the expression of DAZAP1 mRNA

NCBI chr19:1,407,586...1,435,684
Ensembl chr19:1,407,569...1,435,687

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dopamine beta-hydroxylase

increases response to substance
decreases response to substance

DBH gene polymorphism results in increased susceptibility to Cocaine
DBH gene mutant form results in decreased susceptibility to Cocaine

PMID:10673769 PMID:12555232 PMID:18083142

NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329

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drebrin 1

multiple interactions

Cocaine deficiency promotes the reaction [SMARCA4 protein binds to DBN1 promoter]

NCBI chr 5:177,456,610...177,473,634
Ensembl chr 5:177,456,608...177,474,401

G

DDB1 and CUL4 associated factor 8

affects expression

Cocaine affects the expression of DCAF8 mRNA

NCBI chr 1:160,215,720...160,262,549
Ensembl chr 1:160,215,715...160,262,549

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DNA damage inducible transcript 3

affects expression
increases expression

Cocaine affects the expression of DDIT3 mRNA
Cocaine results in increased expression of DDIT3 mRNA

PMID:15681117 PMID:20187946 PMID:23644055

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

discoidin domain receptor tyrosine kinase 2

decreases expression

Cocaine results in decreased expression of DDR2 mRNA

NCBI chr 1:162,630,863...162,787,405
Ensembl chr 1:162,631,373...162,787,405

G

DEAD-box helicase 41

decreases expression

Cocaine results in decreased expression of DDX41 mRNA

NCBI chr 5:177,511,577...177,516,961
Ensembl chr 5:177,511,577...177,516,961

G

DExD-box helicase 50

affects expression

Cocaine affects the expression of DDX50 mRNA

NCBI chr10:68,901,315...68,946,847
Ensembl chr10:68,901,286...68,946,847

G

DEAD-box helicase 6

increases expression

Cocaine results in increased expression of DDX6 mRNA

NCBI chr11:118,747,763...118,791,744
Ensembl chr11:118,747,763...118,791,164

G

DEAF1 transcription factor

decreases expression

Cocaine results in decreased expression of DEAF1 mRNA

PMID:15009677 PMID:16710320

NCBI chr11:644,220...707,083
Ensembl chr11:644,233...707,118

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desert hedgehog signaling molecule

affects expression

Cocaine affects the expression of DHH mRNA

NCBI chr12:49,086,656...49,094,801
Ensembl chr12:49,086,656...49,094,801

G

DExH-box helicase 30

affects expression

Cocaine affects the expression of DHX30 mRNA

NCBI chr 3:47,803,138...47,850,193
Ensembl chr 3:47,802,909...47,850,195

G

divergent protein kinase domain 1B

affects expression

Cocaine affects the expression of DIPK1B mRNA

NCBI chr 9:136,712,572...136,724,742
Ensembl chr 9:136,712,572...136,724,742

G

discs large MAGUK scaffold protein 2

increases expression

Cocaine results in increased expression of DLG2 protein

NCBI chr11:83,455,012...85,628,373
Ensembl chr11:83,455,012...85,628,335

G

discs large MAGUK scaffold protein 4

affects expression
increases expression
multiple interactions
decreases response to substance
decreases expression

Cocaine affects the expression of DLG4 mRNA; Cocaine affects the expression of DLG4 protein
Cocaine results in increased expression of DLG4 protein
ILK mutant form inhibits the reaction [Cocaine results in increased expression of DLG4 protein]
DLG4 protein results in decreased susceptibility to Cocaine
Cocaine results in decreased expression of DLG4 mRNA

PMID:14980210 PMID:19629758 PMID:20187946 PMID:20534846 PMID:20600170

NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,841

G

delta like non-canonical Notch ligand 2

decreases expression
multiple interactions

Cocaine results in decreased expression of DLK2 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of DLK2 mRNA]

NCBI chr 6:43,450,352...43,456,632
Ensembl chr 6:43,450,352...43,456,632

G

dynein axonemal heavy chain 8

affects response to substance

DNAH8 gene SNP affects the susceptibility to Cocaine

NCBI chr 6:38,715,311...39,030,792
Ensembl chr 6:38,715,311...39,030,792

G

dynamin 1

affects expression

Cocaine affects the expression of DNM1 mRNA

NCBI chr 9:128,203,379...128,255,244
Ensembl chr 9:128,191,655...128,255,248

G

dynamin 1 like

multiple interactions
increases phosphorylation

[Cocaine co-treated with Cocaine deficiency] promotes the reaction [RUNX2 protein binds to DNM1L promoter]
Cocaine results in increased phosphorylation of DNM1L protein

PMID:30158054 PMID:31494168

NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650

G

dynamin 2

affects expression

Cocaine affects the expression of DNM2 mRNA

NCBI chr19:10,718,079...10,831,903
Ensembl chr19:10,718,055...10,833,488

G

dynamin 3

affects expression

Cocaine affects the expression of DNM3 mRNA

NCBI chr 1:171,841,498...172,418,466
Ensembl chr 1:171,817,887...172,418,466

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dynamin binding protein

decreases expression

Cocaine results in decreased expression of DNMBP mRNA

NCBI chr10:99,875,571...100,009,947
Ensembl chr10:99,875,577...100,009,947

G

DNA methyltransferase 3 beta

decreases expression
multiple interactions

Cocaine results in decreased expression of DNMT3B mRNA; Cocaine results in decreased expression of DNMT3B protein
Methionine inhibits the reaction [Cocaine results in decreased expression of DNMT3B mRNA]; Methionine inhibits the reaction [Cocaine results in decreased expression of DNMT3B protein]

NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359

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2'-deoxynucleoside 5'-phosphate N-hydrolase 1

decreases expression

Cocaine results in decreased expression of DNPH1 mRNA

PMID:15009677 PMID:16710320

NCBI chr 6:43,225,629...43,229,481
Ensembl chr 6:43,225,629...43,229,481

G

double PHD fingers 2

increases expression

Cocaine results in increased expression of DPF2 mRNA

NCBI chr11:65,333,852...65,354,262
Ensembl chr11:65,333,843...65,354,262

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dihydropyrimidinase like 2

multiple interactions

[Cocaine affects the activity of PRKACA protein] which affects the phosphorylation of DPYSL2 protein

NCBI chr 8:26,514,031...26,658,175
Ensembl chr 8:26,514,031...26,658,178

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dihydropyrimidinase like 3

affects expression

Cocaine affects the expression of DPYSL3 mRNA

NCBI chr 5:147,390,808...147,510,068
Ensembl chr 5:147,390,808...147,510,068

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dopamine receptor D1

multiple interactions
affects expression
increases expression
decreases expression
affects response to substance
increases response to substance
decreases response to substance

1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; [Cocaine binds to SIGMAR1 protein] affects the folding of [SIGMAR1 protein binds to DRD1 protein]; Cocaine affects the localization of [DRD1 protein binds to SIGMAR1 protein]; Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cocaine promotes the reaction [DRD1 protein binds to SIGMAR1 protein]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]
Cocaine affects the expression of DRD1 protein
Cocaine deficiency results in increased expression of DRD1 mRNA
Cocaine results in decreased expression of DRD1 protein
DRD1 protein affects the susceptibility to Cocaine
DRD1 results in increased susceptibility to Cocaine
DRD1 gene mutant form results in decreased susceptibility to Cocaine
Cocaine promotes the reaction [DRD1 protein results in increased expression of FOS protein]; Cocaine promotes the reaction [DRD1 protein results in increased expression of NEO1 protein]; Cocaine promotes the reaction [DRD1 protein results in increased expression of PDYN protein]; Cocaine promotes the reaction [DRD1 protein results in increased expression of SYT7 protein]; Cocaine promotes the reaction [DRD1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cocaine promotes the reaction [DRD1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; DRD1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; DRD1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
[anhydroecgonine methyl ester co-treated with Cocaine] results in decreased expression of DRD1 protein; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Cocaine results in increased expression of FOS protein]; Cocaine affects the reaction [SCH 23390 binds to DRD1 protein]; DRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein alternative form]; DRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein]

PMID:2213551 PMID:8001143 PMID:11421588 PMID:11602327 PMID:15049517 More...

NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182

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dopamine receptor D2

decreases expression
increases expression
affects response to substance
increases activity
multiple interactions
affects expression
decreases response to substance
increases response to substance

Cocaine results in decreased expression of DRD2 mRNA; Cocaine results in decreased expression of DRD2 protein
Cocaine deficiency results in increased expression of DRD2 mRNA; Cocaine results in increased expression of DRD2 protein
DRD2 protein affects the susceptibility to Cocaine
Cocaine results in increased activity of DRD2 protein
Cocaine results in increased expression of DRD2 mRNA; Cocaine results in increased expression of DRD2 protein
Cocaine affects the reaction [Spiperone binds to DRD2 protein]; Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]; Methadone affects the reaction [Cocaine affects the expression of DRD2 mRNA]; Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]
Cocaine affects the expression of DRD2; Cocaine affects the expression of DRD2 mRNA; Cocaine affects the expression of DRD2 protein
DRD2 protein results in decreased susceptibility to Cocaine
PDYN protein affects the reaction [Cocaine affects the expression of DRD2 protein]
DRD2 results in increased susceptibility to Cocaine
DRD2 polymorphism results in increased susceptibility to Cocaine
Cocaine affects the reaction [Raclopride binds to DRD2]

PMID:2213551 PMID:9892293 PMID:11126397 PMID:11602327 PMID:11790512 More...

NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691

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dopamine receptor D3

decreases expression
decreases response to substance
increases expression
increases activity
affects expression
affects activity
multiple interactions
affects response to substance

Cocaine results in decreased expression of DRD3 protein
DRD3 results in decreased susceptibility to Cocaine
Cocaine results in increased expression of DRD3 mRNA
Cocaine results in increased activity of DRD3 protein
Cocaine affects the expression of DRD3 protein
Cocaine affects the activity of DRD3 protein
DRD3 protein results in decreased susceptibility to Cocaine
7-hydroxy-2-N,N-dipropylaminotetralin inhibits the reaction [Cocaine affects the activity of DRD3 protein]; Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]; KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]
DRD3 affects the susceptibility to Cocaine
[3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD3 protein] which results in decreased susceptibility to Cocaine; [3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol co-treated with Cocaine] affects the localization of DRD3 protein; Cocaine promotes the reaction [DRD3 protein results in decreased expression of FOS protein]; Cocaine promotes the reaction [DRD3 protein results in decreased expression of NEO1 protein]; Cocaine promotes the reaction [DRD3 protein results in decreased expression of PDYN protein]; Cocaine promotes the reaction [DRD3 protein results in decreased expression of SYT7 protein]; Cocaine promotes the reaction [DRD3 protein results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; Cocaine promotes the reaction [DRD3 protein results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; DRD3 protein affects the reaction [Cocaine results in increased expression of NTS mRNA]; DRD3 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]; DRD3 protein inhibits the reaction [Cocaine results in increased expression of PDYN protein]; SB 277011 inhibits the reaction [[3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD3 protein] which results in decreased susceptibility to Cocaine]

PMID:10523822 PMID:10943692 PMID:11120399 PMID:12099907 PMID:15056714 More...

NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407

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dopamine receptor D4

increases response to substance
affects expression

DRD4 polymorphism results in increased susceptibility to Cocaine
Cocaine affects the expression of DRD4 mRNA

PMID:17671965 PMID:20187946

NCBI chr11:637,269...640,706
Ensembl chr11:637,269...640,706

G

dopamine receptor D5

affects expression

Cocaine affects the expression of DRD5 mRNA

NCBI chr 4:9,781,634...9,784,009
Ensembl chr 4:9,781,634...9,784,009

G

dystrophin related protein 2

affects expression

Cocaine affects the expression of DRP2 protein

NCBI chr X:101,219,786...101,264,502
Ensembl chr X:101,219,769...101,264,502

G

desmoplakin

increases expression

Cocaine results in increased expression of DSP protein

NCBI chr 6:7,541,671...7,586,714
Ensembl chr 6:7,541,338...7,586,714

G

dual specificity phosphatase 1

affects expression
increases phosphorylation

Cocaine affects the expression of DUSP1 mRNA
Cocaine results in increased phosphorylation of DUSP1 protein

PMID:18822274 PMID:20187946

NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195

G

dual specificity phosphatase 5

affects expression
increases expression

Cocaine affects the expression of CPG21 mRNA
Cocaine results in increased expression of DUSP5 mRNA

PMID:20187946 PMID:27899881

NCBI chr10:110,497,907...110,511,533
Ensembl chr10:110,497,907...110,511,533

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dual specificity phosphatase 8

multiple interactions
increases expression

5,7-Dihydroxytryptamine inhibits the reaction [Cocaine results in increased expression of DUSP8 mRNA]

NCBI chr11:1,554,051...1,572,848
Ensembl chr11:1,554,051...1,572,271

G

dishevelled segment polarity protein 1

affects expression

Cocaine affects the expression of DVL1 mRNA

NCBI chr 1:1,335,278...1,349,418
Ensembl chr 1:1,335,276...1,349,418

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dynein cytoplasmic 1 intermediate chain 1

decreases expression

Cocaine results in decreased expression of DYNC1I1 mRNA

NCBI chr 7:95,772,554...96,110,322
Ensembl chr 7:95,772,506...96,110,322

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dynein cytoplasmic 1 light intermediate chain 2

increases expression

Cocaine results in increased expression of DYNC1LI2 protein

NCBI chr16:66,720,893...66,751,609
Ensembl chr16:66,720,893...66,751,609

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dynein light chain LC8-type 1

affects expression

Cocaine affects the expression of DYNLL1 mRNA

NCBI chr12:120,469,842...120,498,493
Ensembl chr12:120,469,850...120,498,493

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enoyl-CoA delta isomerase 2

affects expression

Cocaine affects the expression of ECI2 mRNA

NCBI chr 6:4,115,706...4,135,575
Ensembl chr 6:4,115,693...4,135,597

G

endothelin 1

increases expression

Cocaine results in increased expression of EDN1 protein

PMID:9714087 PMID:11948058 PMID:17420087 PMID:18813882

NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194

G

endothelin receptor type A

increases expression

Cocaine results in increased expression of EDNRA protein

PMID:17420087 PMID:18813882

NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954

G

endothelin receptor type B

affects expression

Cocaine affects the expression of EDNRB mRNA

NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529

G

eukaryotic translation elongation factor 1 alpha 1

affects expression

Cocaine affects the expression of EEF1A1 mRNA

NCBI chr 6:73,515,750...73,521,032
Ensembl chr 6:73,489,308...73,525,587

G

eukaryotic translation elongation factor 1 alpha 2

affects expression

Cocaine affects the expression of EEF1A2 mRNA

NCBI chr20:63,488,014...63,499,083
Ensembl chr20:63,488,013...63,499,239

G

eukaryotic translation elongation factor 1 gamma

decreases expression

Cocaine results in decreased expression of EEF1G mRNA

NCBI chr11:62,559,596...62,573,891
Ensembl chr11:62,559,596...62,574,086

G

EF-hand calcium binding domain 3

affects expression
decreases expression

Cocaine affects the expression of EFCAB3 mRNA
Cocaine results in decreased expression of EFCAB3 mRNA

PMID:17898221 PMID:20187946

NCBI chr17:62,370,218...62,416,480
Ensembl chr17:62,343,941...62,416,480

G

ephrin A1

affects expression

Cocaine affects the expression of EFNA1 mRNA

NCBI chr 1:155,127,876...155,134,899
Ensembl chr 1:155,127,876...155,134,899

G

ephrin A2

affects expression

Cocaine affects the expression of EFNA2 mRNA

NCBI chr19:1,284,227...1,301,431
Ensembl chr19:1,285,873...1,301,431

G

ephrin A3

affects expression

Cocaine affects the expression of EFNA3 mRNA

NCBI chr 1:155,078,837...155,087,538
Ensembl chr 1:155,078,837...155,087,538

G

ephrin A4

affects expression

Cocaine affects the expression of EFNA4 mRNA

NCBI chr 1:155,063,740...155,069,553
Ensembl chr 1:155,063,737...155,069,553

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ephrin A5

increases expression

Cocaine results in increased expression of EFNA5 mRNA

NCBI chr 5:107,376,894...107,670,937
Ensembl chr 5:107,376,894...107,670,937

G

ephrin B1

increases expression

Cocaine results in increased expression of EFNB1 mRNA

PMID:15691709 PMID:17898221

NCBI chr X:68,829,021...68,842,160
Ensembl chr X:68,829,021...68,842,160

G

ephrin B2

increases expression

Cocaine results in increased expression of EFNB2 mRNA

NCBI chr13:106,489,745...106,535,662
Ensembl chr13:106,489,745...106,535,662

G

ephrin B3

increases expression

Cocaine results in increased expression of EFNB3 mRNA

NCBI chr17:7,705,202...7,711,372
Ensembl chr17:7,705,202...7,711,372

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elongation factor Tu GTP binding domain containing 2

affects expression

Cocaine affects the expression of EFTUD2 mRNA

NCBI chr17:44,849,948...44,899,445
Ensembl chr17:44,849,948...44,899,445

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epidermal growth factor receptor

decreases expression

Cocaine results in decreased expression of EGFR mRNA

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

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early growth response 1

affects expression
decreases expression
increases expression
multiple interactions
increases response to substance

Cocaine affects the expression of EGR1 mRNA
Cocaine deficiency results in decreased expression of EGR1 mRNA
Cocaine results in increased expression of EGR1 protein
NPPC protein inhibits the reaction [Cocaine results in increased expression of EGR1 mRNA]
Cocaine results in increased expression of EGR1 mRNA; Cocaine results in increased expression of EGR1 protein
EGR1 results in increased susceptibility to Cocaine
[Cocaine co-treated with Caffeine] results in increased expression of EGR1 mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of EGR1 mRNA]

PMID:1347779 PMID:7905595 PMID:9890435 PMID:10971643 PMID:11860464 More...

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

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early growth response 2

increases expression
affects expression

Cocaine results in increased expression of EGR2 mRNA
Cocaine affects the expression of EGR2 mRNA

PMID:20056891 PMID:20187946 PMID:27899881

NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,819,167

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early growth response 3

affects expression
decreases expression
multiple interactions
increases expression

Cocaine affects the expression of EGR3 mRNA
Cocaine deficiency results in decreased expression of EGR3 mRNA
[Cocaine co-treated with Cocaine deficiency] promotes the reaction [RUNX2 protein binds to EGR3 promoter]
Cocaine results in increased expression of EGR3 mRNA

PMID:16459018 PMID:20187946 PMID:27126842 PMID:30158054

NCBI chr 8:22,687,659...22,693,480
Ensembl chr 8:22,687,659...22,693,480

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early growth response 4

increases expression

Cocaine results in increased expression of EGR4 mRNA

NCBI chr 2:73,290,929...73,293,548
Ensembl chr 2:73,290,929...73,293,701

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EH domain containing 2

decreases expression

Cocaine results in decreased expression of EHD2 mRNA

NCBI chr19:47,713,422...47,743,134
Ensembl chr19:47,713,422...47,743,134

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euchromatic histone lysine methyltransferase 1

decreases expression

Cocaine results in decreased expression of EHMT1 mRNA

NCBI chr 9:137,619,005...137,836,127
Ensembl chr 9:137,618,992...137,870,016

G

euchromatic histone lysine methyltransferase 2

multiple interactions
decreases response to substance
decreases expression

Cocaine inhibits the reaction [Cocaine promotes the reaction [EHMT2 protein binds to FOSB protein]]; Cocaine promotes the reaction [EHMT2 protein binds to FOSB protein]; EHMT2 inhibits the reaction [Cocaine results in increased expression of ATM mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of ELMO1 mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of TGFBR1 mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of TNFRSF25 mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of USP9X mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of WNK3 mRNA]; EHMT2 protein inhibits the reaction [Cocaine results in increased expression of FOSB mRNA]
EHMT2 results in decreased susceptibility to Cocaine
Cocaine results in decreased expression of EHMT2 mRNA; Cocaine results in decreased expression of EHMT2 protein

NCBI chr 6:31,879,759...31,897,698
Ensembl chr 6:31,879,759...31,897,698

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eukaryotic translation initiation factor 2 alpha kinase 3

increases expression
multiple interactions

Cocaine results in increased expression of EIF2AK3 protein
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]; N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]

NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518

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eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

Cocaine results in increased phosphorylation of EIF2S1

NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516

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eukaryotic translation initiation factor 3 subunit A

increases expression

Cocaine results in increased expression of EIF3A mRNA

NCBI chr10:119,033,670...119,080,817
Ensembl chr10:119,033,670...119,080,817

G

eukaryotic translation initiation factor 3 subunit B

affects expression

Cocaine affects the expression of EIF3B mRNA

NCBI chr 7:2,354,086...2,380,745
Ensembl chr 7:2,354,086...2,380,745

G

eukaryotic translation initiation factor 3 subunit C

increases expression

Cocaine results in increased expression of EIF3C mRNA

NCBI chr16:28,688,558...28,735,730
Ensembl chr16:28,688,558...28,735,727

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eukaryotic translation initiation factor 3 subunit E

affects expression

Cocaine affects the expression of EIF3E mRNA

NCBI chr 8:108,201,216...108,248,717
Ensembl chr 8:108,162,787...108,443,496

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eukaryotic translation initiation factor 4B

multiple interactions
increases expression

FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of EIF4B mRNA]

NCBI chr12:53,006,456...53,042,215
Ensembl chr12:53,006,282...53,042,215

G

eukaryotic translation initiation factor 5A

decreases expression
affects expression
increases expression

Cocaine results in decreased expression of EIF5A mRNA
Cocaine affects the expression of EIF5A mRNA
Cocaine results in increased expression of EIF5A mRNA

PMID:15009677 PMID:16710320 PMID:20187946

NCBI chr17:7,306,999...7,312,463
Ensembl chr17:7,306,999...7,312,463

G

eukaryotic translation initiation factor 5B

increases expression

Cocaine results in increased expression of EIF5B mRNA

NCBI chr 2:99,337,389...99,401,326
Ensembl chr 2:99,337,389...99,401,326

G

elastase, neutrophil expressed

multiple interactions

[Cocaine affects the reaction [Antibodies, Antineutrophil Cytoplasmic binds to ELANE protein]] which results in decreased activity of ELANE protein; Cocaine affects the reaction [Antibodies, Antineutrophil Cytoplasmic binds to ELANE protein]

NCBI chr19:852,303...856,243
Ensembl chr19:851,014...856,247

G

engulfment and cell motility 1

multiple interactions
increases expression

EHMT2 inhibits the reaction [Cocaine results in increased expression of ELMO1 mRNA]

NCBI chr 7:36,852,906...37,449,326
Ensembl chr 7:36,852,906...37,449,223

G

ER membrane protein complex subunit 9

affects expression

Cocaine affects the expression of EMC9 mRNA

NCBI chr14:24,138,965...24,141,591
Ensembl chr14:24,138,959...24,141,591

G

ENAH actin regulator

increases expression

Cocaine results in increased expression of ENAH mRNA

NCBI chr 1:225,486,829...225,653,878
Ensembl chr 1:225,486,765...225,653,142

G

ectodermal-neural cortex 1

increases expression

Cocaine results in increased expression of ENC1 mRNA

NCBI chr 5:74,627,409...74,640,728
Ensembl chr 5:74,627,406...74,641,424

G

energy homeostasis associated

decreases expression

Cocaine results in decreased expression of ENHO mRNA

NCBI chr 9:34,521,043...34,522,990
Ensembl chr 9:34,521,043...34,522,990

G

enolase 2

decreases expression
increases expression

Cocaine results in decreased expression of ENO2 mRNA
Cocaine results in increased expression of ENO2 protein

PMID:12629581 PMID:17075605

NCBI chr12:6,914,580...6,923,697
Ensembl chr12:6,913,745...6,923,698

G

ectonucleotide pyrophosphatase/phosphodiesterase family member 5

increases expression

Cocaine results in increased expression of ENPP5 mRNA

NCBI chr 6:46,159,185...46,170,980
Ensembl chr 6:46,159,185...46,170,980

G

ectonucleoside triphosphate diphosphohydrolase 2

decreases expression

Cocaine results in decreased expression of ENTPD2 protein

NCBI chr 9:137,048,107...137,054,061
Ensembl chr 9:137,048,107...137,054,061

G

ectonucleoside triphosphate diphosphohydrolase 3

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of ENTPD3 mRNA

NCBI chr 3:40,387,184...40,428,744
Ensembl chr 3:40,387,184...40,428,744

G

EPH receptor A1

affects expression

Cocaine affects the expression of EPHA1 mRNA

NCBI chr 7:143,391,129...143,408,856
Ensembl chr 7:143,390,289...143,408,856

G

EPH receptor A2

affects expression

Cocaine affects the expression of EPHA2 mRNA

NCBI chr 1:16,124,337...16,156,069
Ensembl chr 1:16,124,337...16,156,069

G

EPH receptor A3

affects expression

Cocaine affects the expression of EPHA3 mRNA

NCBI chr 3:89,107,621...89,482,134
Ensembl chr 3:89,107,621...89,482,134

G

EPH receptor A4

affects expression
increases expression

Cocaine affects the expression of EPHA4 mRNA
Cocaine results in increased expression of EPHA4 mRNA

PMID:15691709 PMID:17898221

NCBI chr 2:221,418,027...221,574,202
Ensembl chr 2:221,418,027...221,574,202

G

EPH receptor A5

affects expression

Cocaine affects the expression of EPHA5 mRNA

NCBI chr 4:65,319,567...65,670,489
Ensembl chr 4:65,319,563...65,670,495

G

EPH receptor A7

affects expression

Cocaine affects the expression of EPHA7 mRNA

NCBI chr 6:93,240,020...93,419,559
Ensembl chr 6:93,240,020...93,419,687

G

EPH receptor A8

affects expression

Cocaine affects the expression of EPHA8 mRNA

NCBI chr 1:22,563,489...22,603,595
Ensembl chr 1:22,563,489...22,603,595

G

EPH receptor B1

increases expression

Cocaine results in increased expression of EPHB1 protein
Cocaine results in increased expression of EPHB1 mRNA

PMID:11146119 PMID:15691709

NCBI chr 3:134,795,260...135,260,467
Ensembl chr 3:134,795,260...135,260,467

G

EPH receptor B2

increases expression

Cocaine results in increased expression of EPHB2 mRNA

NCBI chr 1:22,710,838...22,921,500
Ensembl chr 1:22,710,839...22,921,500

G

EPH receptor B3

affects expression

Cocaine affects the expression of EPHB3 mRNA

NCBI chr 3:184,561,785...184,582,408
Ensembl chr 3:184,561,785...184,582,408

G

EPH receptor B4

decreases expression
affects expression

Cocaine results in decreased expression of EPHB4 mRNA
Cocaine affects the expression of EPHB4 mRNA

PMID:15691709 PMID:18000554

NCBI chr 7:100,802,565...100,827,523
Ensembl chr 7:100,802,565...100,827,523

G

EPH receptor B6

affects expression

Cocaine affects the expression of EPHB6 mRNA

NCBI chr 7:142,855,076...142,871,093
Ensembl chr 7:142,855,061...142,871,094

G

erbb2 interacting protein

multiple interactions

HDAC5 affects the reaction [Cocaine affects the expression of ERBIN mRNA]

NCBI chr 5:65,926,575...66,082,546
Ensembl chr 5:65,883,128...66,082,546

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
increases expression

6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased expression of ERN1 protein]; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of ERN1 protein]; N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Cocaine results in increased expression of ERN1 protein]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of ERN1 protein]

NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819

G

ess-2 splicing factor homolog

decreases expression

Cocaine results in decreased expression of ESS2 mRNA

NCBI chr22:19,130,279...19,144,651
Ensembl chr22:19,130,279...19,144,684

G

eukaryotic translation termination factor 1

affects expression

Cocaine affects the expression of ETF1 mRNA

NCBI chr 5:138,506,095...138,543,236
Ensembl chr 5:138,506,095...138,543,236

G

electron transfer flavoprotein subunit alpha

affects expression

Cocaine affects the expression of ETFA mRNA

NCBI chr15:76,215,353...76,311,469
Ensembl chr15:76,188,555...76,311,730

G

exocyst complex component 2

increases expression

Cocaine results in increased expression of EXOC2 protein

NCBI chr 6:485,154...693,139
Ensembl chr 6:485,154...693,139

G

EYA transcriptional coactivator and phosphatase 1

increases expression

Cocaine results in increased expression of EYA1 mRNA

NCBI chr 8:71,197,433...71,548,094
Ensembl chr 8:71,197,433...71,592,025

G

EYA transcriptional coactivator and phosphatase 2

affects expression

Cocaine affects the expression of EYA2 mRNA

NCBI chr20:46,894,843...47,188,844
Ensembl chr20:46,894,624...47,188,844

G

ezrin

decreases expression

Cocaine results in decreased expression of EZR mRNA

NCBI chr 6:158,765,748...158,819,368
Ensembl chr 6:158,765,741...158,819,368

G

Fas associated via death domain

affects expression
multiple interactions
decreases expression

Cocaine affects the expression of FADD mRNA
Raclopride affects the reaction [Cocaine affects the expression of FADD protein]
Cocaine results in decreased expression of FADD protein modified form

NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390

G

fumarylacetoacetate hydrolase domain containing 1

increases expression

Cocaine results in increased expression of FAHD1 protein

NCBI chr16:1,827,206...1,840,207
Ensembl chr16:1,826,967...1,840,207

G

fumarylacetoacetate hydrolase domain containing 2A

affects expression

Cocaine affects the expression of FAHD2A protein

NCBI chr 2:95,402,708...95,421,656
Ensembl chr 2:95,402,708...95,416,616

G

Fas apoptotic inhibitory molecule

affects expression

Cocaine affects the expression of FAIM mRNA

NCBI chr 3:138,608,771...138,633,376
Ensembl chr 3:138,608,606...138,633,376

G

Fas apoptotic inhibitory molecule 2

increases expression

Cocaine results in increased expression of FAIM2 mRNA

NCBI chr12:49,866,896...49,903,900
Ensembl chr12:49,866,896...49,904,217

G

family with sequence similarity 153 member A

increases expression

Cocaine results in increased expression of FAM153A mRNA

NCBI chr 5:177,694,247...177,783,425
Ensembl chr 5:177,707,981...177,784,435

G

family with sequence similarity 184 member B

decreases expression

Cocaine results in decreased expression of FAM184B mRNA

NCBI chr 4:17,629,306...17,781,621
Ensembl chr 4:17,629,306...17,781,621

G

FAM20C golgi associated secretory pathway kinase

affects expression

Cocaine affects the expression of FAM20C mRNA

NCBI chr 7:192,571...260,772
Ensembl chr 7:192,571...260,772

G

family with sequence similarity 78 member B

decreases expression

Cocaine results in decreased expression of FAM78B mRNA

NCBI chr 1:166,055,918...166,167,001
Ensembl chr 1:166,057,426...166,167,001

G

Fas cell surface death receptor

increases expression

Cocaine results in increased expression of FAS mRNA

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

F-box and leucine rich repeat protein 3

increases expression

Cocaine results in increased expression of FBXL3 mRNA

NCBI chr13:77,005,260...77,027,159
Ensembl chr13:76,992,598...77,027,195

G

F-box protein 46

affects expression

Cocaine affects the expression of FBXO46 mRNA

NCBI chr19:45,710,629...45,733,177
Ensembl chr19:45,710,629...45,730,896

G

Fc gamma receptor IIb

decreases expression

Cocaine results in decreased expression of FCGR2B mRNA

NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,143...161,678,654

G

farnesyl-diphosphate farnesyltransferase 1

increases expression

Cocaine results in increased expression of FDFT1 mRNA

NCBI chr 8:11,795,582...11,839,309
Ensembl chr 8:11,795,573...11,839,395

G

FEV transcription factor, ETS family member

decreases expression

Cocaine results in decreased expression of FEV mRNA

NCBI chr 2:218,981,087...218,985,184
Ensembl chr 2:218,981,087...218,985,184

G

FYVE, RhoGEF and PH domain containing 5

increases expression

Cocaine results in increased expression of FGD5 mRNA

NCBI chr 3:14,810,688...14,934,571
Ensembl chr 3:14,810,853...14,934,571

G

fibroblast growth factor 12

affects expression

Cocaine affects the expression of FGF12 mRNA

NCBI chr 3:192,139,390...192,727,541
Ensembl chr 3:192,139,390...192,767,764

G

fibroblast growth factor 2

decreases expression

Cocaine results in decreased expression of FGF2 mRNA

NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236

G

fibroblast growth factor receptor 1

increases expression

Cocaine results in increased expression of FGFR1 mRNA

NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834

G

fumarate hydratase

affects expression

Cocaine affects the expression of FH1 protein

NCBI chr 1:241,497,603...241,519,755
Ensembl chr 1:241,497,511...241,519,799

G

fission, mitochondrial 1

increases expression

Cocaine results in increased expression of FIS1 mRNA

NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316

G

FKBP prolyl isomerase 1B

affects expression

Cocaine affects the expression of FKBP1B mRNA

NCBI chr 2:24,033,206...24,063,681
Ensembl chr 2:24,049,701...24,063,681

G

FKBP prolyl isomerase 5

increases expression

cocaine increases expression of Fkbp5 mRNA in bed nucleus of the stria terminalis, central amygdala and paraventricular nucleus

RGD

NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583

G

FKBP prolyl isomerase like

affects expression

Cocaine affects the expression of FKBPL mRNA

NCBI chr 6:32,128,707...32,130,288
Ensembl chr 6:32,128,707...32,130,288

G

fibronectin leucine rich transmembrane protein 3

increases expression

Cocaine results in increased expression of FLRT3 mRNA

NCBI chr20:14,322,985...14,337,612
Ensembl chr20:14,322,985...14,337,614

G

FLYWCH-type zinc finger 1

decreases expression

Cocaine results in decreased expression of FLYWCH1 mRNA

NCBI chr16:2,911,931...2,951,208
Ensembl chr16:2,911,931...2,951,208

G

fragile X messenger ribonucleoprotein 1

decreases expression

Cocaine results in decreased expression of FMR1 mRNA

NCBI chr X:147,911,919...147,951,125
Ensembl chr X:147,911,919...147,951,125

G

fibronectin type III domain containing 1

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of FNDC1 mRNA

NCBI chr 6:159,169,400...159,272,108
Ensembl chr 6:159,169,400...159,272,108

G

fibronectin type III domain containing 5

affects expression

Cocaine affects the expression of FNDC5 mRNA

NCBI chr 1:32,862,268...32,872,484
Ensembl chr 1:32,862,268...32,872,482

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
affects expression
increases phosphorylation
decreases response to substance
increases activity
decreases expression

[Cocaine co-treated with SLC6A3 protein] results in increased expression of FOS protein; Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]
Cocaine results in increased expression of FOS mRNA; Cocaine results in increased expression of FOS protein
Cocaine affects the expression of FOS mRNA; Cocaine affects the expression of FOS protein
Cocaine results in increased phosphorylation of FOS protein
[Morphine co-treated with Cocaine] affects the expression of FOS; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Cocaine results in increased expression of FOS protein]; Alcohols promotes the reaction [Cocaine results in increased expression of FOS protein]; Baclofen inhibits the reaction [Cocaine results in increased expression of FOS protein]; Chloral Hydrate inhibits the reaction [Cocaine results in increased expression of FOS protein]; Cocaine promotes the reaction [[SK&F 81297 co-treated with Quinpirole] results in increased expression of FOS protein]; Cocaine promotes the reaction [Cocaine results in increased expression of FOS mRNA]; Cocaine promotes the reaction [Ethanol results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of FOS protein]; ecopipam inhibits the reaction [Cocaine results in increased expression of FOS protein]; Ethanol promotes the reaction [Cocaine results in increased expression of FOS protein]; Muscimol inhibits the reaction [Cocaine results in increased expression of FOS protein]; NPPC protein inhibits the reaction [Cocaine results in increased expression of FOS mRNA]; Reserpine inhibits the reaction [Cocaine results in increased expression of FOS protein]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of FOS protein]; Urethane inhibits the reaction [Cocaine results in increased expression of FOS protein]; volinanserin inhibits the reaction [Cocaine results in increased expression of FOS protein]
FOS protein mutant form results in decreased susceptibility to Cocaine
Cocaine results in increased activity of FOS protein
Cocaine deficiency results in decreased expression of FOS protein; Cocaine results in decreased expression of FOS protein
[[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of NEO1 protein; [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of PDYN protein; [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of SYT7 protein; [Cocaine co-treated with Caffeine] results in increased expression of FOS mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of ATPAF1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of CD4 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of CORO7 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of ENTPD3 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of FNDC1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of ITPR1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of NEXN mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of PBX2 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of PER1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of PINX1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of PKNOX2 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of PLPP1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of PRKCZ mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of SHANK3 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of SYT9 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of THRA mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of ADGRA1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of CAB39L mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of CAMK1G mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of CBLN1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of GRIP1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of INA mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of LARGE1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of NRIP3 mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of SATB2 mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of SORCS3 mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of TENM4 mRNA; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOS protein; Baclofen inhibits the reaction [Cocaine results in increased expression of FOS protein]; CDK5R1 protein inhibits the reaction [Cocaine affects the expression of FOS mRNA]; CDK5R1 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased expression of FOS protein]; Cocaine promotes the reaction [Caffeine results in increased expression of FOS mRNA]; Cocaine promotes the reaction [DRD1 protein results in increased expression of FOS protein]; Cocaine promotes the reaction [DRD3 protein results in decreased expression of FOS protein]; cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Cocaine results in increased expression of FOS protein]; DRD3 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of BDNF mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of CALR mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of DLK2 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of HOMER2 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of HS3ST2 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of MAPK11 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of NCALD mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of NPTXR mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of NRN1 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of PRKCA mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of SATB1 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of SEZ6L mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ATP1B3 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ATP8B2 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of CLK1 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of CTSB mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of EIF4B mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of GPC5 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of KCNT1 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of KDM3A mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of LIN7B mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of LZTS3 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of MEPCE mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of NIT2 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of NOS3 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PBX3 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PPP1R7 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PRPF18 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PTPRV mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of SBSN mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of SYNE1 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of SYT2 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of TSPOAP1 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ZFPM1 mRNA]; GPX1 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]; N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of FOS protein]; N-methyl-3-(bis(4'-fluorophenyl)methoxy)tropane inhibits the reaction [Cocaine results in increased expression of FOS protein]; NTRK2 protein affects the reaction [Cocaine affects the expression of FOS protein]; prolinedithiocarbamate inhibits the reaction [Cocaine results in increased expression of FOS protein]; RPS6KA3 affects the reaction [Cocaine results in increased phosphorylation of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [Cocaine results in increased activity of FOS protein]; SL 327 inhibits the reaction [Cocaine results in increased expression of FOS mRNA]; SL 327 inhibits the reaction [Cocaine results in increased expression of FOS protein]

PMID:1498673 PMID:2118661 PMID:7905595 PMID:10415707 PMID:10521585 More...

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression
increases expression
multiple interactions
affects expression

Cocaine results in increased expression of FOSB protein
cocaine increases expression of Fosb protein in dorsal striatum and nucelus accumbens
Cocaine increases expression of Fosb mRNA and protein in Nucleus Accumbens and Caudate Putamen
Cocaine increases expression of Fosb protein in Nucleus Accumbens and Caudate putamen
Cocaine increases expression of Fosb protein in caudate��putamen
Cocaine increases expression of Fosb protein in brain
cocaine increases expression of Fosb protein in Brain
cocaine increases expression of Fosb protein in Nucleus Accumbens and Caudate Putamen
DRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein alternative form]; DRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of FOSB protein]
Cocaine results in increased expression of FOSB mRNA; Cocaine results in increased expression of FOSB protein; Cocaine results in increased expression of FOSB protein alternative form
Cocaine affects the expression of FOSB mRNA; Cocaine affects the expression of FOSB protein
[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein; [JUND protein results in decreased activity of FOSB protein] which results in decreased susceptibility to Cocaine; Cocaine inhibits the reaction [Cocaine promotes the reaction [EHMT2 protein binds to FOSB protein]]; Cocaine promotes the reaction [EHMT2 protein binds to FOSB protein]; EHMT2 protein inhibits the reaction [Cocaine results in increased expression of FOSB mRNA]; N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]; PPP1R1B gene mutant form inhibits the reaction [Cocaine results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]

CTD
RGD

PMID:10103106 PMID:11391778 PMID:11739600 PMID:12417638 PMID:15056714 More...

RGD:401901287, RGD:401900126, RGD:401900166, RGD:401900302, RGD:401851084, RGD:401851078, RGD:401851063

NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179

G

FOS like 1, AP-1 transcription factor subunit

affects expression
decreases expression

Cocaine affects the expression of FOSL1 mRNA
Cocaine results in decreased expression of FOSL1 mRNA

PMID:12117546 PMID:12629581

NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573

G

FOS like 2, AP-1 transcription factor subunit

multiple interactions
decreases expression

Cocaine promotes the reaction [JUN protein binds to FOSL2 protein]
[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein]
Cocaine results in decreased expression of FOSL2 protein

PMID:15056714 PMID:15814102

NCBI chr 2:28,392,858...28,417,317
Ensembl chr 2:28,392,448...28,417,317

G

forkhead box C2

decreases expression

Cocaine results in decreased expression of FOXC2 mRNA

NCBI chr16:86,566,829...86,569,728
Ensembl chr16:86,566,829...86,569,728

G

forkhead box O1

decreases expression

Cocaine results in decreased expression of FOXO1 mRNA

NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641

G

forkhead box P1

increases expression

Cocaine deficiency results in increased expression of FOXP1 mRNA

NCBI chr 3:70,954,708...71,583,978
Ensembl chr 3:70,954,693...71,583,978

G

Fraser extracellular matrix complex subunit 1

increases expression

Cocaine results in increased expression of FRAS1 mRNA

NCBI chr 4:78,057,323...78,544,269
Ensembl chr 4:78,057,323...78,544,269

G

FRAS1 related extracellular matrix 2

decreases expression

Cocaine results in decreased expression of FREM2 mRNA

NCBI chr13:38,687,077...38,887,131
Ensembl chr13:38,687,077...38,887,131

G

FERM domain containing 5

decreases expression

Cocaine results in decreased expression of FRMD5 mRNA

NCBI chr15:43,870,764...44,199,473
Ensembl chr15:43,870,761...44,195,271

G

fibroblast growth factor receptor substrate 3

affects expression

Cocaine affects the expression of FRS3 mRNA

NCBI chr 6:41,770,176...41,779,900
Ensembl chr 6:41,770,176...41,786,542

G

far upstream element binding protein 1

affects expression

Cocaine affects the expression of FUBP1 mRNA

NCBI chr 1:77,944,055...77,979,501
Ensembl chr 1:77,944,055...77,979,110

G

fucosyltransferase 8

affects expression

Cocaine affects the expression of FUT8 mRNA

NCBI chr14:65,356,842...65,744,121
Ensembl chr14:65,410,592...65,744,121

G

frizzled class receptor 6

affects expression

Cocaine affects the expression of FZD6 mRNA

NCBI chr 8:103,298,494...103,332,866
Ensembl chr 8:103,298,433...103,332,866

G

glucose-6-phosphate dehydrogenase

increases expression

Cocaine results in increased expression of G6PD protein

NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572

G

gamma-aminobutyric acid type B receptor subunit 1

affects expression
increases expression
decreases expression

Cocaine affects the expression of GABBR1 mRNA
Cocaine results in increased expression of GABBR1 mRNA
Cocaine results in decreased expression of GABBR1 mRNA

PMID:11793422 PMID:16076954 PMID:20187946

NCBI chr 6:29,602,238...29,633,183
Ensembl chr 6:29,555,629...29,633,976

G

gamma-aminobutyric acid type B receptor subunit 2

decreases phosphorylation

Cocaine results in decreased phosphorylation of GABBR2 protein

NCBI chr 9:98,288,109...98,708,935
Ensembl chr 9:98,288,109...98,708,935

G

gamma-aminobutyric acid type A receptor subunit alpha1

affects expression
multiple interactions

Cocaine affects the expression of GABRA1 protein
Cocaine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
1-(3-chlorophenyl)piperazine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 3,4-Methylenedioxyamphetamine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine promotes the reaction [1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine promotes the reaction [3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]

PMID:20826313 PMID:23266428 PMID:32209479

NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981

G

gamma-aminobutyric acid type A receptor subunit beta1

increases expression

Cocaine results in increased expression of GABRB1 mRNA

NCBI chr 4:46,993,647...47,426,447
Ensembl chr 4:46,993,723...47,426,447

G

gamma-aminobutyric acid type A receptor subunit beta2

multiple interactions

1-(3-chlorophenyl)piperazine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 3,4-Methylenedioxyamphetamine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine promotes the reaction [1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine promotes the reaction [3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
Cocaine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]

PMID:23266428 PMID:32209479

NCBI chr 5:161,288,436...161,548,404
Ensembl chr 5:161,288,429...161,549,044

G

gamma-aminobutyric acid type A receptor subunit beta3

affects expression
multiple interactions

Cocaine affects the expression of GABRB3 mRNA
Cocaine affects the phosphorylation of and affects the expression of GABRB3 protein

PMID:20187946 PMID:20826313

NCBI chr15:26,543,552...26,773,763
Ensembl chr15:26,543,552...26,939,539

G

gamma-aminobutyric acid type A receptor subunit gamma2

multiple interactions
increases expression

1-(3-chlorophenyl)piperazine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 3,4-Methylenedioxyamphetamine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine promotes the reaction [1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine promotes the reaction [3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
Cocaine deficiency results in increased expression of GABRG2 mRNA
Cocaine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]

PMID:23266428 PMID:27126842 PMID:32209479

NCBI chr 5:162,067,465...162,155,539
Ensembl chr 5:162,000,057...162,162,977

G

glutamate decarboxylase 1

decreases expression
increases expression

Cocaine results in decreased expression of GAD1 mRNA
Cocaine results in increased expression of GAD1 protein

PMID:12629581 PMID:15295023 PMID:18611417

NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151

G

galanin and GMAP prepropeptide

multiple interactions

GAL protein inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; GAL protein inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175

G

galactokinase 1

affects expression

Cocaine affects the expression of GALK1 mRNA

NCBI chr17:75,751,469...75,765,192
Ensembl chr17:75,751,594...75,765,236

G

polypeptide N-acetylgalactosaminyltransferase 1

increases expression

Cocaine results in increased expression of GALNT1 mRNA

NCBI chr18:35,580,922...35,711,834
Ensembl chr18:35,581,117...35,711,834

G

polypeptide N-acetylgalactosaminyltransferase 16

affects expression

Cocaine affects the expression of GALNT16 mRNA

NCBI chr14:69,259,631...69,386,337
Ensembl chr14:69,259,277...69,357,033

G

growth associated protein 43

decreases expression

Cocaine results in decreased expression of GAP43 mRNA

NCBI chr 3:115,623,510...115,721,483
Ensembl chr 3:115,623,510...115,721,490

G

growth arrest specific 2

affects expression

Cocaine affects the expression of GAS2 mRNA

NCBI chr11:22,626,002...22,813,055
Ensembl chr11:22,625,509...22,813,001

G

GRIP and coiled-coil domain containing 1

increases expression

Cocaine results in increased expression of GCC1 mRNA

NCBI chr 7:127,580,628...127,585,596
Ensembl chr 7:127,580,628...127,593,611

G

glutamate-cysteine ligase catalytic subunit

increases expression
multiple interactions

Cocaine results in increased expression of GCLC mRNA
PRKCD protein affects the reaction [Cocaine results in increased expression of GCLC mRNA]; rottlerin promotes the reaction [Cocaine results in increased expression of GCLC mRNA]

NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970

G

glutamate-cysteine ligase modifier subunit

affects expression
multiple interactions
increases expression

Cocaine affects the expression of GCLM mRNA
PRKCD protein affects the reaction [Cocaine results in increased expression of GCLM mRNA]; rottlerin promotes the reaction [Cocaine results in increased expression of GCLM mRNA]

PMID:20187946 PMID:30393195

NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456

G

glucosaminyl (N-acetyl) transferase 2 (I blood group)

increases expression

Cocaine deficiency results in increased expression of GCNT2 mRNA

NCBI chr 6:10,521,351...10,629,368
Ensembl chr 6:10,492,223...10,629,368

G

ganglioside induced differentiation associated protein 1

increases expression

Cocaine results in increased expression of GDAP1 protein

NCBI chr 8:74,350,403...74,488,872
Ensembl chr 8:74,320,613...74,518,007

G

ganglioside induced differentiation associated protein 1 like 1

decreases expression

Cocaine results in decreased expression of GDAP1L1 protein

NCBI chr20:44,247,099...44,280,947
Ensembl chr20:44,247,099...44,280,947

G

glial cell derived neurotrophic factor

decreases expression

Cocaine results in decreased expression of GDNF mRNA

NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041

G

GTP binding protein overexpressed in skeletal muscle

increases expression

Cocaine results in increased expression of GEM mRNA

NCBI chr 8:94,249,253...94,262,319
Ensembl chr 8:94,249,253...94,262,350

G

glial fibrillary acidic protein

increases expression
decreases expression
affects expression

Cocaine results in increased expression of GFAP protein
Cocaine results in decreased expression of GFAP protein
Cocaine affects the expression of GFAP mRNA; Cocaine affects the expression of GFAP protein

PMID:11391778 PMID:11882367 PMID:12670315 PMID:15814102 PMID:20187946

NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937

G

GDNF family receptor alpha 2

affects expression

Cocaine affects the expression of GFRA2 mRNA

NCBI chr 8:21,690,398...21,812,345
Ensembl chr 8:21,690,398...21,812,357

G

growth hormone 1

multiple interactions

Cocaine inhibits the reaction [4-hydroxybutyric acid results in increased secretion of GH1 protein]; Cocaine inhibits the reaction [Sodium Oxybate results in increased expression of GH1 protein]
Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]

PMID:9413023 PMID:10657535 PMID:15099682

NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839

G

GID complex subunit 8 homolog

affects expression

Cocaine affects the expression of GID8 mRNA

NCBI chr20:62,938,147...62,948,475
Ensembl chr20:62,938,147...62,948,475

G

GTPase, IMAP family member 1

affects expression

Cocaine affects the expression of GIMAP1 mRNA

NCBI chr 7:150,716,613...150,724,284
Ensembl chr 7:150,716,606...150,724,284

G

GTPase, IMAP family member 5

affects expression

Cocaine affects the expression of GIMAP5 mRNA

NCBI chr 7:150,737,418...150,743,646
Ensembl chr 7:150,722,253...150,750,033

G

GINS complex subunit 3

decreases expression

Cocaine results in decreased expression of GINS3 mRNA

NCBI chr16:58,392,471...58,406,147
Ensembl chr16:58,295,080...58,406,147

G

GIPC PDZ domain containing family member 1

affects expression

Cocaine affects the expression of GIPC1 mRNA

NCBI chr19:14,477,762...14,496,127
Ensembl chr19:14,477,760...14,496,149

G

gap junction protein alpha 5

increases expression

Cocaine results in increased expression of GJA5 mRNA

NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362

G

gap junction protein beta 1

affects expression

Cocaine affects the expression of GJB1 mRNA; Cocaine affects the expression of GJB1 protein

NCBI chr X:71,215,239...71,225,516
Ensembl chr X:71,212,811...71,225,516

G

gap junction protein beta 2

decreases expression

Cocaine results in decreased expression of GJB2 mRNA

NCBI chr13:20,187,470...20,192,938
Ensembl chr13:20,187,463...20,192,938

G

gap junction protein beta 5

decreases expression

Cocaine results in decreased expression of GJB5 mRNA

NCBI chr 1:34,755,047...34,758,512
Ensembl chr 1:34,755,047...34,758,512

G

gap junction protein delta 2

affects expression

Cocaine affects the expression of GJD2 mRNA; Cocaine affects the expression of GJD2 protein

NCBI chr15:34,751,032...34,754,998
Ensembl chr15:34,751,032...34,754,998

G

GLI family zinc finger 2

decreases expression

Cocaine results in decreased expression of GLI2 mRNA

NCBI chr 2:120,735,868...120,992,653
Ensembl chr 2:120,735,623...120,992,653

G

glucagon like peptide 2 receptor

decreases expression

Cocaine results in decreased expression of GLP2R mRNA

NCBI chr17:9,825,924...9,892,099
Ensembl chr17:9,822,206...9,892,099

G

glycine receptor alpha 1

multiple interactions

Cocaine inhibits the reaction [Glycine results in increased activity of GLRA1 protein]; Dronabinol inhibits the reaction [Cocaine inhibits the reaction [Glycine results in increased activity of GLRA1 protein]]

NCBI chr 5:151,822,513...151,924,851
Ensembl chr 5:151,822,513...151,924,851

G

glutaredoxin 3

affects expression

Cocaine affects the expression of GLRX3 mRNA

NCBI chr10:130,136,391...130,180,377
Ensembl chr10:130,136,391...130,184,521

G

G protein subunit alpha o1

decreases expression
multiple interactions

Cocaine results in decreased expression of GNAO1 mRNA
[Cocaine affects the activity of PRKACA protein] which affects the phosphorylation of GNAO1 protein alternative form

PMID:12629581 PMID:19457111

NCBI chr16:56,191,489...56,357,444
Ensembl chr16:56,191,390...56,357,444

G

G protein subunit alpha transducin 1

increases expression

Cocaine results in increased expression of GNAT1 mRNA

NCBI chr 3:50,191,610...50,197,696
Ensembl chr 3:50,191,610...50,197,696

G

G protein subunit beta 1

decreases expression
increases expression

Cocaine results in decreased expression of GNB1 mRNA
Cocaine results in increased expression of GNB1 mRNA

PMID:12629581 PMID:16076954

NCBI chr 1:1,785,286...1,891,087
Ensembl chr 1:1,785,285...1,892,292

G

G protein subunit beta 2

affects expression

Cocaine affects the expression of GNB2 mRNA

NCBI chr 7:100,673,740...100,679,169
Ensembl chr 7:100,673,567...100,679,174

G

G protein subunit beta 4

multiple interactions

HDAC5 affects the reaction [Cocaine affects the expression of GNB4 mRNA]

NCBI chr 3:179,396,088...179,527,798
Ensembl chr 3:179,396,088...179,451,476

G

G protein subunit gamma 12

affects expression

Cocaine affects the expression of GNG12 mRNA

NCBI chr 1:67,701,475...67,833,467
Ensembl chr 1:67,701,475...67,833,467

G

gonadotropin releasing hormone 1

decreases expression
multiple interactions

Cocaine results in decreased expression of GNRH1 protein
GPX1 protein inhibits the reaction [Cocaine results in decreased expression of GNRH1 protein]; prolinedithiocarbamate inhibits the reaction [Cocaine results in decreased expression of GNRH1 protein]

NCBI chr 8:25,419,258...25,425,040
Ensembl chr 8:25,419,258...25,424,654

G

glycoprotein 2

affects expression

Cocaine affects the expression of GP2 mRNA

NCBI chr16:20,309,574...20,327,513
Ensembl chr16:20,309,574...20,327,808

G

glypican 5

increases expression
multiple interactions

Cocaine results in increased expression of GPC5 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of GPC5 mRNA]

NCBI chr13:91,398,621...92,867,237
Ensembl chr13:91,398,621...92,873,682

G

G protein-coupled estrogen receptor 1

increases expression

Cocaine results in increased expression of GPER1 mRNA

NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815

G

gephyrin

increases phosphorylation
multiple interactions

Cocaine results in increased phosphorylation of GPHN protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Cocaine results in increased phosphorylation of GPHN protein]

NCBI chr14:66,508,147...67,735,355
Ensembl chr14:66,507,407...67,181,803

G

glycoprotein M6A

decreases expression

Cocaine results in decreased expression of GPM6A mRNA

NCBI chr 4:175,632,937...176,002,691
Ensembl chr 4:175,632,934...176,002,664

G

glycoprotein M6B

decreases expression

Cocaine results in decreased expression of GPM6B mRNA

NCBI chr X:13,770,939...13,938,638
Ensembl chr X:13,770,939...13,938,638

G

G protein-coupled receptor 157

decreases expression

Cocaine results in decreased expression of GPR157 mRNA

NCBI chr 1:9,100,305...9,129,102
Ensembl chr 1:9,100,305...9,129,102

G

G protein-coupled receptor 3

increases expression

Cocaine results in increased expression of GPR3 mRNA

NCBI chr 1:27,392,622...27,395,814
Ensembl chr 1:27,392,622...27,395,814

G

G protein-coupled receptor 88

affects expression
increases expression

Cocaine affects the expression of GPR88 mRNA
Cocaine deficiency results in increased expression of GPR88 mRNA

PMID:20187946 PMID:27126842

NCBI chr 1:100,538,139...100,542,021
Ensembl chr 1:100,538,139...100,542,021

G

G protein-coupled receptor associated sorting protein 1

affects expression

Cocaine affects the expression of GPRASP1 mRNA

NCBI chr X:102,651,483...102,659,083
Ensembl chr X:102,651,092...102,659,083

G

G protein signaling modulator 1

affects expression

Cocaine affects the expression of GPSM1 protein

NCBI chr 9:136,327,539...136,359,601
Ensembl chr 9:136,327,476...136,359,605

G

glutamic--pyruvic transaminase

increases activity
multiple interactions

Cocaine results in increased activity of GPT protein
PRKCD protein affects the reaction [Cocaine results in increased activity of GPT protein]; rottlerin inhibits the reaction [Cocaine results in increased activity of GPT protein]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

glutathione peroxidase 1

increases expression
multiple interactions
affects response to substance

Cocaine results in increased expression of GPX1 protein
GPX1 affects the reaction [Cocaine results in increased activity of SOD1 protein]; GPX1 affects the reaction [Cocaine results in increased activity of SOD2 protein]; GPX1 affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; GPX1 affects the reaction [Cocaine results in increased cleavage of PRKCD protein]; GPX1 protein affects the susceptibility to [Cocaine co-treated with prolinedithiocarbamate]; GPX1 protein inhibits the reaction [Cocaine affects the localization of RELA protein]; GPX1 protein inhibits the reaction [Cocaine results in decreased expression of GNRH1 protein]; GPX1 protein inhibits the reaction [Cocaine results in increased activity of and affects the localization of RELA protein]; GPX1 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]; prolinedithiocarbamate promotes the reaction [Cocaine results in increased expression of GPX1 protein]
GPX1 protein affects the susceptibility to Cocaine

PMID:30027653 PMID:31059705

NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605

G

growth factor receptor bound protein 2

increases expression

Cocaine results in increased expression of GRB2 protein

NCBI chr17:75,318,076...75,405,678
Ensembl chr17:75,318,076...75,405,709

G

glutamate ionotropic receptor AMPA type subunit 1

decreases response to substance
increases phosphorylation
increases expression
decreases expression
affects response to substance
increases response to substance
decreases phosphorylation
multiple interactions
affects expression

GRIA1 results in decreased susceptibility to Cocaine
Cocaine increases phosphorylation of Gria1 protein in the hippocampal formation
Cocaine increases expression of Gria1 protein in the ventral tegmental area
Cocaine increases expression of Gria1 mRNA in the nucleus accumbens
Cocaine results in decreased expression of GRIA1 mRNA; Cocaine results in decreased expression of GRIA1 protein
Cocaine results in increased phosphorylation of GRIA1 protein
GRIA1 protein affects the susceptibility to Cocaine
GRIA1 protein results in increased susceptibility to Cocaine
GRIA1 protein mutant form results in decreased susceptibility to Cocaine; GRIA1 results in decreased susceptibility to Cocaine
Cocaine results in increased expression of GRIA1 mRNA; Cocaine results in increased expression of GRIA1 protein
Cocaine results in decreased phosphorylation of GRIA1 protein
6-methyl-2-(phenylethynyl)pyridine affects the reaction [Cocaine affects the phosphorylation of GRIA1 protein]; Cocaine affects the phosphorylation of and affects the expression of GRIA1 protein; Cocaine results in increased phosphorylation of and results in increased transport of GRIA1 protein; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIA1 protein]; ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIA1 protein]; ILK mutant form inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]; Ondansetron inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]; roscovitine inhibits the reaction [Cocaine results in decreased phosphorylation of GRIA1 protein]; U 0126 inhibits the reaction [Cocaine results in increased expression of GRIA1 protein]
Cocaine affects the expression of GRIA1 mRNA; Cocaine affects the expression of GRIA1 protein
Cocaine results in increased expression of and results in increased phosphorylation of GRIA1 protein; Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of GRIA1 protein]; resveratrol promotes the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]

CTD
RGD

PMID:9886066 PMID:11268215 PMID:11801363 PMID:12511956 PMID:12787079 More...

RGD:405649734, RGD:405649733, RGD:405096667

NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869

G

glutamate ionotropic receptor AMPA type subunit 2

increases expression
decreases response to substance
multiple interactions
affects expression

Cocaine results in increased expression of GRIA2 protein
GRIA2 results in decreased susceptibility to Cocaine
Cocaine results in increased phosphorylation of and affects the localization of GRIA2 protein
Cocaine results in increased expression of GRIA2 mRNA
Cocaine affects the expression of GRIA2 mRNA; Cocaine affects the expression of GRIA2 protein

PMID:9886066 PMID:12511956 PMID:12787079 PMID:15140200 PMID:16363995 More...

NCBI chr 4:157,220,120...157,366,075
Ensembl chr 4:157,204,182...157,387,146

G

glutamate ionotropic receptor AMPA type subunit 3

decreases expression
affects expression
increases expression

Cocaine results in decreased expression of GRIA3 mRNA
Cocaine affects the expression of GRIA3 protein
Cocaine results in increased expression of GRIA3 protein

PMID:9886066 PMID:12511956 PMID:15140200 PMID:16363995

NCBI chr X:123,184,278...123,490,915
Ensembl chr X:123,184,153...123,490,915

G

glutamate ionotropic receptor AMPA type subunit 4

affects expression

Cocaine affects the expression of GRIA4 mRNA
Cocaine affects the expression of GRIA4 protein

PMID:9886066 PMID:15140200

NCBI chr11:105,609,616...105,982,090
Ensembl chr11:105,609,535...105,982,090

G

glutamate ionotropic receptor kainate type subunit 1

affects expression

Cocaine affects the expression of GRIK1 mRNA; Cocaine affects the expression of GRIK1 protein

PMID:12358776 PMID:15140200

NCBI chr21:29,536,933...29,939,996
Ensembl chr21:29,536,933...29,940,033

G

glutamate ionotropic receptor kainate type subunit 2

affects expression

Cocaine affects the expression of GRIK2 protein

NCBI chr 6:101,393,708...102,070,083
Ensembl chr 6:100,962,701...102,081,622

G

glutamate ionotropic receptor kainate type subunit 3

affects expression

Cocaine affects the expression of GRIK3 protein

NCBI chr 1:36,795,527...37,034,515
Ensembl chr 1:36,795,527...37,034,515

G

glutamate ionotropic receptor kainate type subunit 5

affects expression

Cocaine affects the expression of GRIK5 protein

NCBI chr19:41,998,324...42,070,206
Ensembl chr19:41,998,321...42,070,206

G

glutamate ionotropic receptor NMDA type subunit 1

multiple interactions
affects response to substance
increases expression
affects phosphorylation
affects expression
decreases expression

6-methyl-2-(phenylethynyl)pyridine affects the reaction [Cocaine affects the phosphorylation of GRIN1 protein]; Cocaine affects the phosphorylation of and affects the expression of GRIN1 protein; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN1 protein]; ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN1 protein]
GRIN1 protein affects the susceptibility to Cocaine
Cocaine results in increased expression of GRIN1 mRNA; Cocaine results in increased expression of GRIN1 protein
Cocaine affects the expression of GRIN1 mRNA; Cocaine affects the expression of GRIN1 protein
Cocaine results in decreased expression of GRIN1 mRNA

PMID:9886066 PMID:11032893 PMID:11801363 PMID:12457264 PMID:12670717 More...

NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756

G

glutamate ionotropic receptor NMDA type subunit 2A

multiple interactions
increases expression
affects expression

HDAC5 affects the reaction [Cocaine affects the expression of GRIN2A mRNA]
ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN2A protein]
Cocaine results in increased expression of GRIN2A mRNA; Cocaine results in increased expression of GRIN2A protein
Cocaine affects the expression of GRIN2A mRNA; Cocaine affects the expression of GRIN2A protein

PMID:17898221 PMID:17988634 PMID:19105975 PMID:19306440 PMID:19474322 More...

NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928

G

glutamate ionotropic receptor NMDA type subunit 2B

increases expression
affects response to substance
multiple interactions
affects expression
decreases phosphorylation

Cocaine results in increased expression of GRIN2B protein
GRIN2B protein affects the susceptibility to Cocaine
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]; ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]; Ondansetron inhibits the reaction [Cocaine results in decreased phosphorylation of GRIN2B protein]; Ondansetron inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]
Cocaine affects the expression of GRIN2B mRNA; Cocaine affects the expression of GRIN2B protein

PMID:11032893 PMID:11801363 PMID:15140200 PMID:16794574 PMID:19105975 More...

NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002

G

glutamate ionotropic receptor NMDA type subunit 2C

affects expression

Cocaine affects the expression of GRIN2C mRNA

NCBI chr17:74,842,023...74,861,532
Ensembl chr17:74,842,023...74,861,504

G

glutamate ionotropic receptor NMDA type subunit 2D

increases expression
affects expression

Cocaine results in increased expression of GRIN2D mRNA
Cocaine affects the expression of GRIN2D mRNA

PMID:16076954 PMID:20187946

NCBI chr19:48,393,668...48,444,931
Ensembl chr19:48,393,668...48,444,931

G

glutamate ionotropic receptor NMDA type subunit 3A

affects expression

Cocaine affects the expression of GRIN3A protein

NCBI chr 9:101,569,352...101,738,647
Ensembl chr 9:101,569,352...101,738,647

G

glutamate ionotropic receptor NMDA type subunit 3B

affects expression

Cocaine affects the expression of GRIN3B protein

NCBI chr19:1,000,419...1,009,732
Ensembl chr19:1,000,419...1,009,732

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

increases expression

Cocaine results in increased expression of GRINA mRNA

NCBI chr 8:143,990,056...143,993,415
Ensembl chr 8:143,990,056...143,993,415

G

glutamate receptor interacting protein 1

increases phosphorylation
multiple interactions

Cocaine results in increased phosphorylation of GRIP1 protein
[Cocaine co-treated with FOS protein mutant form] results in increased expression of GRIP1 mRNA

PMID:18355967 PMID:19439608

NCBI chr12:66,347,431...67,069,338
Ensembl chr12:66,347,431...67,069,162

G

glutamate receptor interacting protein 2

increases expression

Cocaine results in increased expression of GRIP2 mRNA

NCBI chr 3:14,489,107...14,603,017
Ensembl chr 3:14,489,107...14,556,075

G

G protein-coupled receptor kinase 2

affects expression
increases expression

Cocaine affects the expression of GRK2 mRNA
Cocaine results in increased expression of GRK2 mRNA

PMID:16076954 PMID:20187946

NCBI chr11:67,266,473...67,286,556
Ensembl chr11:67,266,473...67,286,556

G

G protein-coupled receptor kinase 6

affects expression

Cocaine affects the expression of GRK6 mRNA

NCBI chr 5:177,425,523...177,442,891
Ensembl chr 5:177,403,204...177,442,901

G

glutamate metabotropic receptor 1

affects response to substance

GRM1 affects the susceptibility to Cocaine

NCBI chr 6:146,027,707...146,437,601
Ensembl chr 6:146,027,646...146,437,601

G

glutamate metabotropic receptor 2

increases activity
affects expression
decreases activity

Cocaine results in increased activity of GRM2 protein
Cocaine affects the expression of GRM2 protein
Cocaine results in decreased activity of GRM2 protein

PMID:18673447 PMID:19105975 PMID:20416862

NCBI chr 3:51,707,068...51,718,613
Ensembl chr 3:51,707,068...51,718,613

G

glutamate metabotropic receptor 3

increases activity
affects expression

Cocaine results in increased activity of GRM3 protein
Cocaine affects the expression of GRM3 protein

PMID:19105975 PMID:20416862

NCBI chr 7:86,643,909...86,864,879
Ensembl chr 7:86,643,909...86,864,879

G

glutamate metabotropic receptor 5

affects expression
increases expression
multiple interactions
affects localization
decreases response to substance

Cocaine affects the expression of GRM5 mRNA
Cocaine deficiency results in increased expression of GRM5 mRNA
Cocaine results in decreased expression of and results in decreased activity of GRM5 protein
Cocaine results in increased expression of GRM5 mRNA
Cocaine affects the expression of GRM5 protein
Cocaine affects the localization of GRM5 protein
GRM5 mutant form results in decreased susceptibility to Cocaine

PMID:9886066 PMID:15295029 PMID:17898221 PMID:19105975 PMID:19118598 More...

NCBI chr11:88,504,642...89,065,982
Ensembl chr11:88,504,576...89,065,982

G

glutamate metabotropic receptor 7

increases expression

Cocaine results in increased expression of GRM7 mRNA

NCBI chr 3:6,861,115...7,741,533
Ensembl chr 3:6,770,001...7,741,533

G

gastrin releasing peptide receptor

affects expression

Cocaine affects the expression of GRPR mRNA

NCBI chr X:16,123,565...16,153,518
Ensembl chr X:16,123,565...16,153,518

G

glycogen synthase kinase 3 alpha

affects expression

Cocaine affects the expression of GSK3A mRNA

NCBI chr19:42,230,190...42,242,602
Ensembl chr19:42,226,225...42,242,625

G

glycogen synthase kinase 3 beta

multiple interactions
increases activity

Cocaine results in decreased phosphorylation of and results in increased activity of GSK3B protein
Cocaine results in increased activity of GSK3B protein

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

gelsolin

decreases expression

Cocaine results in decreased expression of GSN mRNA

NCBI chr 9:121,201,483...121,332,842
Ensembl chr 9:121,207,794...121,332,843

G

glutathione-disulfide reductase

increases expression

Cocaine deficiency results in increased expression of GSR mRNA

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

glutathione S-transferase omega 1

affects expression

Cocaine affects the expression of GSTO1 protein

NCBI chr10:104,254,173...104,267,455
Ensembl chr10:104,235,356...104,267,459

G

glutathione S-transferase pi 1

affects response to substance

GSTP1 polymorphism affects the susceptibility to Cocaine

NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656

G

guanylate cyclase 1 soluble subunit alpha 1

increases expression

Cocaine results in increased expression of GUCY1A1 mRNA

NCBI chr 4:155,666,848...155,737,059
Ensembl chr 4:155,666,726...155,737,059

G

guanylate cyclase 1 soluble subunit beta 1

increases expression

Cocaine results in increased expression of GUCY1B1 mRNA

NCBI chr 4:155,759,021...155,807,811
Ensembl chr 4:155,758,992...155,807,811

G

glycogenin 1

decreases expression

Cocaine results in decreased expression of GYG1 protein

NCBI chr 3:148,991,540...149,031,775
Ensembl chr 3:148,991,408...149,031,775

G

granzyme M

affects expression

Cocaine affects the expression of GZMM mRNA

NCBI chr19:544,053...549,922
Ensembl chr19:544,034...549,924

G

heart and neural crest derivatives expressed 1

affects expression

Cocaine affects the expression of HAND1 mRNA

NCBI chr 5:154,474,972...154,478,227
Ensembl chr 5:154,474,972...154,478,227

G

hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

increases expression

Cocaine results in increased expression of HCN2 mRNA

NCBI chr19:589,881...617,159
Ensembl chr19:589,881...617,159

G

hypocretin neuropeptide precursor

affects expression
multiple interactions

Cocaine affects the expression of HCRT mRNA
Methadone affects the reaction [Cocaine affects the expression of HCRT mRNA]

NCBI chr17:42,184,060...42,185,452
Ensembl chr17:42,184,060...42,185,452

G

hypocretin receptor 2

affects expression

Cocaine affects the expression of HCRTR2 protein

NCBI chr 6:55,106,469...55,284,713
Ensembl chr 6:55,106,460...55,282,617

G

histone deacetylase 10

affects expression

Cocaine affects the expression of HDAC10 mRNA

NCBI chr22:50,245,183...50,251,265
Ensembl chr22:50,245,183...50,251,405

G

histone deacetylase 5

decreases activity
decreases response to substance
multiple interactions

Cocaine results in decreased activity of HDAC5 protein
HDAC5 results in decreased susceptibility to Cocaine
Cocaine results in increased phosphorylation of and results in increased localization of HDAC5 protein; HDAC5 affects the reaction [Cocaine affects the expression of ABCA5 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of ADAM1A mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of CUEDC1 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of ERBIN mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of GNB4 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of GRIN2A mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of KCNK4 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of KCNQ5 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of PRM1 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of RAPGEF6 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of RGS20 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of SUV39H1 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of TACR1 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of WNT5A mRNA]

NCBI chr17:44,076,753...44,123,641
Ensembl chr17:44,076,746...44,123,702

G

histone deacetylase 6

multiple interactions
decreases expression

(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Cocaine results in decreased expression of HDAC6 protein]

NCBI chr X:48,801,398...48,824,982
Ensembl chr X:48,801,377...48,824,982

G

histidine decarboxylase

affects response to substance

HDC gene mutant form affects the susceptibility to Cocaine

NCBI chr15:50,241,947...50,265,726
Ensembl chr15:50,241,947...50,265,965

G

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

decreases expression

Cocaine results in decreased expression of HECW2 mRNA

NCBI chr 2:196,194,072...196,593,554
Ensembl chr 2:196,189,099...196,593,684

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

increases expression

Cocaine results in increased expression of HERC1 mRNA

NCBI chr15:63,608,618...63,833,948
Ensembl chr15:63,608,618...63,833,948

G

hedgehog interacting protein

decreases expression

Cocaine results in decreased expression of HHIP mRNA

NCBI chr 4:144,646,156...144,745,271
Ensembl chr 4:144,646,156...144,745,271

G

hypoxia inducible factor 1 subunit alpha

decreases expression

Cocaine results in decreased expression of HIF1A mRNA

NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259

G

HIG1 hypoxia inducible domain family member 1A

affects expression
increases expression

Cocaine affects the expression of HIGD1A mRNA
Cocaine results in increased expression of HIGD1A protein

PMID:20187946 PMID:25100957

NCBI chr 3:42,782,908...42,804,490
Ensembl chr 3:42,782,908...42,804,490

G

major histocompatibility complex, class II, DR alpha

affects expression

Cocaine affects the expression of RT1-DA mRNA

NCBI chr 6:32,439,887...32,445,046
Ensembl chr 6:32,439,878...32,445,046

G

high mobility group AT-hook 1

affects expression

Cocaine affects the expression of HMGA1 mRNA

NCBI chr 6:34,236,873...34,246,231
Ensembl chr 6:34,236,873...34,246,231

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

Cocaine results in increased expression of HMGCS1 mRNA

NCBI chr 5:43,287,470...43,313,412
Ensembl chr 5:43,287,470...43,313,512

G

homer scaffold protein 1

increases response to substance
increases expression
affects expression
multiple interactions
decreases response to substance

HOMER1 polymorphism results in increased susceptibility to Cocaine
Cocaine results in increased expression of HOMER1 protein
Cocaine affects the expression of HOMER1 mRNA; Cocaine affects the expression of HOMER1 protein
Cocaine affects the expression of and affects the localization of HOMER1 protein
HOMER1 protein results in decreased susceptibility to Cocaine
Cocaine results in increased expression of HOMER1 mRNA

PMID:15294147 PMID:16314758 PMID:18355967 PMID:19105975 PMID:19118598 More...

NCBI chr 5:79,372,636...79,514,134
Ensembl chr 5:79,372,636...79,514,134

G

homer scaffold protein 2

multiple interactions
affects expression
decreases response to substance
decreases expression

Cocaine affects the reaction [HOMER2 mutant form results in decreased secretion of Excitatory Amino Acid Agents]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of HOMER2 mRNA]
Cocaine affects the expression of HOMER2 mRNA
HOMER2 protein results in decreased susceptibility to Cocaine; HOMER2 results in decreased susceptibility to Cocaine

PMID:14684444 PMID:15294147 PMID:15545022 PMID:18355967 PMID:20187946

NCBI chr15:82,834,661...82,986,157
Ensembl chr15:82,836,946...82,986,153

G

homer scaffold protein 3

affects expression

Cocaine affects the expression of HOMER3 mRNA

NCBI chr19:18,929,201...18,941,217
Ensembl chr19:18,929,201...18,941,261

G

hippocalcin

increases expression

Cocaine deficiency results in increased expression of HPCA mRNA

NCBI chr 1:32,885,996...32,894,646
Ensembl chr 1:32,885,994...32,898,441

G

hippocalcin like 1

decreases expression

Cocaine results in decreased expression of HPCAL1 mRNA

NCBI chr 2:10,302,904...10,427,604
Ensembl chr 2:10,302,889...10,427,617

G

hippocalcin like 4

affects expression
increases expression

Cocaine affects the expression of HPCAL4 mRNA
Cocaine results in increased expression of HPCAL4 mRNA

PMID:17898221 PMID:20187946

NCBI chr 1:39,678,648...39,691,433
Ensembl chr 1:39,678,648...39,691,485

G

4-hydroxyphenylpyruvate dioxygenase

increases expression

Cocaine results in increased expression of HPD mRNA

NCBI chr12:121,839,527...121,888,611
Ensembl chr12:121,839,527...121,863,596

G

HPS1 biogenesis of lysosomal organelles complex 3 subunit 1

affects expression

Cocaine affects the expression of HPS1 mRNA

NCBI chr10:98,413,948...98,446,935
Ensembl chr10:98,410,939...98,446,963

G

heparan sulfate-glucosamine 3-sulfotransferase 2

decreases expression
multiple interactions

Cocaine results in decreased expression of HS3ST2 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of HS3ST2 mRNA]

NCBI chr16:22,814,162...22,916,338
Ensembl chr16:22,814,162...22,916,338

G

hydroxysteroid 17-beta dehydrogenase 6

decreases expression

Cocaine results in decreased expression of HSD17B6 mRNA

NCBI chr12:56,763,324...56,787,790
Ensembl chr12:56,752,161...56,787,790

G

heat shock transcription factor 1

affects expression

Cocaine affects the expression of HSF1 mRNA

NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720

G

heat shock protein 90 alpha family class A member 1

increases expression

Cocaine deficiency results in increased expression of HSP90AA1 mRNA

NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699

G

heat shock protein 90 alpha family class B member 1

decreases expression

Cocaine results in decreased expression of HSP90AB1 mRNA

NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888

G

heat shock protein family A (Hsp70) member 1A

increases expression

Cocaine results in increased expression of HSPA1A mRNA

NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946

G

heat shock protein family A (Hsp70) member 1B

affects expression
increases expression

Cocaine affects the expression of HSPA1B mRNA
Cocaine results in increased expression of HSPA1B mRNA

PMID:15681117 PMID:27899881

NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

Cocaine results in increased expression of HSPA5 mRNA
Cocaine results in increased expression of HSPA5 mRNA; Cocaine results in increased expression of HSPA5 protein
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]; N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]

PMID:15009677 PMID:17303341 PMID:23644055

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

heat shock protein family A (Hsp70) member 9

multiple interactions
increases expression

Anisomycin inhibits the reaction [Cocaine results in increased expression of HSPA9 protein]

NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,675

G

heat shock protein family B (small) member 1

increases expression

Cocaine results in increased expression of HSPB1 mRNA

NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295

G

heat shock protein family D (Hsp60) member 1

affects expression

Cocaine affects the expression of HSPD1 protein

NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737

G

HIV-1 Tat specific factor 1

multiple interactions

[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Cocaine] results in decreased phosphorylation of HTATSF1 protein

NCBI chr X:136,497,229...136,512,346
Ensembl chr X:136,497,079...136,512,346

G

5-hydroxytryptamine receptor 1A

multiple interactions

Cocaine inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]

NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507

G

5-hydroxytryptamine receptor 1B

increases response to substance
affects activity
multiple interactions

HTR1B mutant form results in increased susceptibility to Cocaine
Cocaine affects the activity of HTR1B protein
[3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one binds to and results in increased activity of HTR1B protein] which affects the susceptibility to Cocaine; [5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole binds to and results in increased activity of HTR1B protein] which affects the susceptibility to Cocaine; [CP 94253 binds to and results in increased activity of HTR1B protein] which affects the susceptibility to Cocaine

PMID:9603521 PMID:9822762 PMID:17074068

NCBI chr 6:77,460,924...77,463,491
Ensembl chr 6:77,460,924...77,463,491

G

5-hydroxytryptamine receptor 1D

affects expression

Cocaine affects the expression of HTR1D mRNA

NCBI chr 1:23,191,895...23,217,502
Ensembl chr 1:23,191,895...23,217,502

G

5-hydroxytryptamine receptor 2A

multiple interactions
affects activity
affects response to substance

[alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine; [Alprenolol co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]; [Metergoline binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine; [Methiothepin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine; [Mianserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine; [Yohimbine co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]; Cocaine inhibits the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]
Cocaine affects the activity of HTR2A protein
Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]; Ketanserin inhibits the reaction [Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]]
HTR2A protein affects the susceptibility to Cocaine

PMID:8392199 PMID:10764922 PMID:10773209 PMID:10773215 PMID:17259860

NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076

G

5-hydroxytryptamine receptor 2C

multiple interactions
decreases expression
increases response to substance

[1-(3-chlorophenyl)piperazine binds to and results in increased activity of HTR2C protein] which results in increased susceptibility to Cocaine; [6-chloro-2-(1-piperazinyl)pyrazine binds to and results in increased activity of HTR2C protein] which results in increased susceptibility to Cocaine; HTR2C protein affects the reaction [Cocaine results in increased abundance of Dopamine]
Cocaine results in decreased expression of HTR2C mRNA
HTR2C mutant form results in increased susceptibility to Cocaine

PMID:10541732 PMID:12427861 PMID:16076954

NCBI chr X:114,584,086...114,910,061
Ensembl chr X:114,584,078...114,910,061

G

5-hydroxytryptamine receptor 3A

decreases response to substance
multiple interactions

HTR3A mutant form results in decreased susceptibility to Cocaine
Cocaine inhibits the reaction [Serotonin results in increased activity of HTR3A protein]

PMID:17559417 PMID:32209479

NCBI chr11:113,975,108...113,990,313
Ensembl chr11:113,975,075...113,990,313

G

5-hydroxytryptamine receptor 4

affects response to substance

HTR4 protein affects the susceptibility to Cocaine

NCBI chr 5:148,451,032...148,654,527
Ensembl chr 5:148,446,042...148,677,235

G

5-hydroxytryptamine receptor 6

multiple interactions

[Ro 4-6790 binds to and results in decreased activity of HTR6 protein] which results in decreased susceptibility to Cocaine; [SB 271046 binds to and results in decreased activity of HTR6 protein] which results in decreased susceptibility to Cocaine

NCBI chr 1:19,664,875...19,680,966
Ensembl chr 1:19,664,875...19,680,966

G

hydrogen voltage gated channel 1

decreases expression

Cocaine results in decreased expression of HVCN1 mRNA

NCBI chr12:110,648,686...110,704,952
Ensembl chr12:110,627,841...110,704,950

G

intercellular adhesion molecule 1

increases expression

Cocaine results in increased expression of ICAM1 mRNA

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

interactor of little elongation complex ELL subunit 2

affects response to substance

ICE2 gene SNP affects the susceptibility to Cocaine

NCBI chr15:60,419,609...60,479,142
Ensembl chr15:60,419,609...60,479,160

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

affects expression

Cocaine affects the expression of IDH3A mRNA

NCBI chr15:78,149,362...78,171,945
Ensembl chr15:78,131,498...78,171,945

G

immediate early response 5

affects expression

Cocaine affects the expression of IER5 mRNA

NCBI chr 1:181,088,700...181,092,900
Ensembl chr 1:181,088,700...181,092,900

G

interferon gamma

affects secretion
decreases expression
multiple interactions

Cocaine affects the secretion of IFNG protein
Cocaine results in decreased expression of IFNG mRNA; Cocaine results in decreased expression of IFNG protein
[Cocaine co-treated with Heroin] results in increased expression of IFNG protein

PMID:9787120 PMID:16766138 PMID:29673861

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

interferon related developmental regulator 1

affects expression

Cocaine affects the expression of IFRD1 mRNA

NCBI chr 7:112,423,174...112,477,203
Ensembl chr 7:112,422,887...112,481,017

G

intraflagellar transport 81

increases expression

Cocaine results in increased expression of IFT81 mRNA

NCBI chr12:110,124,357...110,218,793
Ensembl chr12:110,124,335...110,218,793

G

insulin like growth factor 1 receptor

affects expression

Cocaine affects the expression of IGF1R mRNA

NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530

G

insulin like growth factor 2

decreases expression

Cocaine results in decreased expression of IGF2 mRNA

NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391

G

insulin like growth factor binding protein 2

decreases expression

Cocaine results in decreased expression of IGFBP2 mRNA

NCBI chr 2:216,632,828...216,664,436
Ensembl chr 2:216,632,828...216,664,436

G

immunoglobulin superfamily member 8

affects expression

Cocaine affects the expression of IGSF8 mRNA

NCBI chr 1:160,091,339...160,099,468
Ensembl chr 1:160,091,340...160,098,943

G

inhibitor of nuclear factor kappa B kinase subunit beta

affects expression

Cocaine affects the expression of IKBKB mRNA

NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460

G

interleukin 10

multiple interactions
increases expression
decreases secretion

[Cocaine co-treated with Heroin] results in increased expression of IL10 protein
Cocaine results in increased expression of IL10 protein
Cocaine results in decreased secretion of IL10 protein

PMID:9787120 PMID:16766138

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 16

decreases expression

Cocaine results in decreased expression of IL16 mRNA

NCBI chr15:81,182,712...81,314,058
Ensembl chr15:81,159,575...81,314,058

G

interleukin 18 binding protein

affects expression

Cocaine affects the expression of IL18BP mRNA

NCBI chr11:71,998,909...72,008,200
Ensembl chr11:71,998,613...72,007,315

G

interleukin 1 alpha

affects expression

Cocaine affects the expression of IL1A mRNA

NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493

G

interleukin 1 beta

increases expression

Cocaine results in increased expression of IL1B mRNA

PMID:20948987 PMID:26558777

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 2

multiple interactions

[Cocaine co-treated with Heroin] results in increased expression of IL2 protein

NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725

G

interleukin 2 receptor subunit alpha

decreases secretion

Cocaine results in decreased secretion of IL2RA protein

NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370

G

interleukin 4

multiple interactions

[Cocaine co-treated with Heroin] results in increased expression of IL4 protein

NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678

G

interleukin 4 induced 1

decreases expression

Cocaine results in decreased expression of IL4I1 mRNA

NCBI chr19:49,889,654...49,929,504
Ensembl chr19:49,889,654...49,929,539

G

interleukin 6

decreases expression
affects response to substance
increases expression
multiple interactions

Cocaine results in decreased expression of IL6 protein
IL6 protein affects the susceptibility to Cocaine
Cocaine results in increased expression of IL6 mRNA; Cocaine results in increased expression of IL6 protein
[IL6 protein affects the susceptibility to Cocaine] which affects the expression of TNF mRNA; [IL6 protein affects the susceptibility to Cocaine] which affects the expression of TNF protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased phosphorylation of JAK2 protein]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased phosphorylation of STAT3 protein]]; IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]; IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]; IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]; IL6 protein affects the reaction [Cocaine results in increased phosphorylation of JAK2 protein]; IL6 protein affects the reaction [Cocaine results in increased phosphorylation of STAT3 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]]; TNF protein affects the reaction [IL6 protein affects the susceptibility to Cocaine]

PMID:10864098 PMID:17068203 PMID:29673861

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

interleukin 6 receptor

affects response to substance

IL6R protein affects the susceptibility to Cocaine

NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450

G

integrin linked kinase

multiple interactions
increases expression

Cocaine affects the reaction [ILK protein affects the phosphorylation of AKT1 protein]; ILK mutant form inhibits the reaction [Cocaine results in increased expression of DLG4 protein]; ILK mutant form inhibits the reaction [Cocaine results in increased expression of SYN1 protein]; ILK mutant form inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]
Cocaine results in increased expression of ILK protein

PMID:18702665 PMID:19629758

NCBI chr11:6,603,774...6,610,870
Ensembl chr11:6,603,708...6,610,874

G

internexin neuronal intermediate filament protein alpha

multiple interactions
decreases expression

[Cocaine co-treated with FOS protein mutant form] results in increased expression of INA mRNA
Cocaine results in decreased expression of INA mRNA

NCBI chr10:103,277,138...103,290,346
Ensembl chr10:103,277,138...103,290,346

G

inhibin subunit alpha

decreases expression

Cocaine results in decreased expression of INHA mRNA

NCBI chr 2:219,572,310...219,575,711
Ensembl chr 2:219,569,162...219,575,711

G

insulin

decreases expression

Cocaine results in decreased expression of INS protein

NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221

G

interferon regulatory factor 9

decreases expression

Cocaine results in decreased expression of IRF9 mRNA

NCBI chr14:24,161,265...24,166,565
Ensembl chr14:24,161,234...24,168,043

G

insulin receptor substrate 2

increases expression

Cocaine results in increased expression of IRS2 mRNA

NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583

G

integrin subunit beta 1

affects expression

Cocaine affects the expression of ITGB1 protein

NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792

G

integrin subunit beta 1 binding protein 1

increases expression

Cocaine results in increased expression of ITGB1BP1 mRNA

PMID:15009677 PMID:16710320

NCBI chr 2:9,403,475...9,423,569
Ensembl chr 2:9,403,475...9,423,528

G

integrin subunit beta 3

affects expression

Cocaine affects the expression of ITGB3 protein

NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,827...47,313,743

G

integrin subunit beta 5

affects expression

Cocaine affects the expression of ITGB5 mRNA

NCBI chr 3:124,761,948...124,901,418
Ensembl chr 3:124,761,948...124,901,418

G

integrin subunit beta 6

increases expression

Cocaine results in increased expression of ITGB6 mRNA

NCBI chr 2:160,099,671...160,200,272
Ensembl chr 2:160,099,667...160,200,313

G

integrin subunit beta 7

decreases expression

Cocaine results in decreased expression of ITGB7 mRNA

NCBI chr12:53,191,323...53,207,251
Ensembl chr12:53,191,323...53,207,282

G

inositol-trisphosphate 3-kinase B

increases expression

Cocaine results in increased expression of ITPKB mRNA

NCBI chr 1:226,631,690...226,739,282
Ensembl chr 1:226,631,690...226,739,323

G

inositol 1,4,5-trisphosphate receptor type 1

multiple interactions
increases expression

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of ITPR1 mRNA
Cocaine results in increased expression of ITPR1 protein

PMID:18355967 PMID:25100957

NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,506

G

jagged canonical Notch ligand 2

affects expression

Cocaine affects the expression of JAG2 mRNA

NCBI chr14:105,140,995...105,168,776
Ensembl chr14:105,140,982...105,168,824

G

Janus kinase 2

multiple interactions
increases phosphorylation

alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased phosphorylation of JAK2 protein]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cocaine results in increased phosphorylation of JAK2 protein]; IL6 protein affects the reaction [Cocaine results in increased phosphorylation of JAK2 protein]; TNF protein affects the reaction [Cocaine results in increased phosphorylation of JAK2 protein]

NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948

G

janus kinase and microtubule interacting protein 2

increases expression

Cocaine results in increased expression of JAKMIP2 mRNA

NCBI chr 5:147,585,438...147,782,728
Ensembl chr 5:147,585,438...147,782,775

G

Jun dimerization protein 2

affects expression

Cocaine affects the expression of JDP2 mRNA

NCBI chr14:75,426,943...75,474,107
Ensembl chr14:75,427,716...75,474,111

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
affects expression

Cocaine promotes the reaction [JUN protein binds to FOSL2 protein]
Cocaine results in increased expression of JUN protein modified form
Cocaine affects the expression of JUN protein

PMID:15814102 PMID:16179556 PMID:17635674 PMID:18355967

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

JunB proto-oncogene, AP-1 transcription factor subunit

affects expression
increases expression
multiple interactions

Cocaine affects the expression of JUNB protein
Cocaine results in increased expression of JUNB mRNA
Cocaine results in increased expression of JUNB protein
Cocaine promotes the reaction [[SK&F 81297 co-treated with Quinpirole] results in increased expression of JUNB protein]; NPPC protein inhibits the reaction [Cocaine results in increased expression of JUNB mRNA]
Cocaine affects the expression of JUNB mRNA
SL 327 inhibits the reaction [Cocaine results in increased expression of JUNB protein]

PMID:1347779 PMID:11860464 PMID:12122080 PMID:15814102 PMID:16263220 More...

NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

Cocaine results in decreased expression of JUND protein
[JUND protein results in decreased activity of FOSB protein] which results in decreased susceptibility to Cocaine

PMID:15814102 PMID:20056891

NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622

G

junction plakoglobin

affects expression

Cocaine affects the expression of JUP mRNA

NCBI chr17:41,754,609...41,786,711
Ensembl chr17:41,754,604...41,786,931

G

kalirin RhoGEF kinase

affects expression

Cocaine affects the expression of KALRN mRNA

NCBI chr 3:124,033,369...124,726,325
Ensembl chr 3:124,033,369...124,726,325

G

katanin regulatory subunit B1

affects expression

Cocaine affects the expression of KATNB1 mRNA

NCBI chr16:57,735,770...57,757,244
Ensembl chr16:57,735,739...57,757,244

G

potassium voltage-gated channel subfamily A member 2

multiple interactions

Cocaine affects the reaction [NTRK2 protein affects the expression of KCNA2 mRNA]

NCBI chr 1:110,593,580...110,631,440
Ensembl chr 1:110,519,837...110,631,474

G

potassium voltage-gated channel subfamily A member 6

increases expression

Cocaine results in increased expression of KCNA6 mRNA

NCBI chr12:4,809,334...4,851,112
Ensembl chr12:4,809,334...4,813,318

G

potassium voltage-gated channel subfamily A regulatory beta subunit 1

decreases expression
affects expression

Cocaine results in decreased expression of KCNAB1 mRNA
Cocaine affects the expression of KCNAB1 mRNA

PMID:18000554 PMID:20187946

NCBI chr 3:156,118,211...156,539,138
Ensembl chr 3:156,037,701...156,538,756

G

potassium voltage-gated channel subfamily B member 1

multiple interactions
affects expression

Cocaine affects the reaction [NTRK2 protein affects the expression of KCNB1 mRNA]
Cocaine affects the expression of KCNB1 mRNA

PMID:20187946 PMID:20947769

NCBI chr20:49,363,877...49,483,362
Ensembl chr20:49,293,394...49,484,297

G

potassium voltage-gated channel subfamily D member 1

multiple interactions

Cocaine affects the reaction [NTRK2 protein affects the expression of KCND1 mRNA]

NCBI chr X:48,961,380...48,971,844
Ensembl chr X:48,961,378...48,971,844

G

potassium voltage-gated channel subfamily D member 2

decreases expression

Cocaine results in decreased expression of KCND2 mRNA

NCBI chr 7:120,272,908...120,750,337
Ensembl chr 7:120,273,175...120,750,337

G

potassium voltage-gated channel subfamily D member 3

increases expression

Cocaine results in increased expression of KCND3 mRNA

NCBI chr 1:111,770,662...111,989,668
Ensembl chr 1:111,770,662...111,989,668

G

potassium voltage-gated channel interacting protein 3

affects expression

Cocaine affects the expression of KCNIP3 mRNA

NCBI chr 2:95,297,347...95,386,077
Ensembl chr 2:95,297,327...95,386,077

G

potassium inwardly rectifying channel subfamily J member 10

increases expression

Cocaine results in increased expression of KCNJ10 mRNA

NCBI chr 1:160,037,467...160,070,160
Ensembl chr 1:159,998,651...160,070,160

G

potassium inwardly rectifying channel subfamily J member 11

decreases response to substance

KCNJ11 results in decreased susceptibility to Cocaine

NCBI chr11:17,385,248...17,389,346
Ensembl chr11:17,365,172...17,389,331

G

potassium inwardly rectifying channel subfamily J member 4

multiple interactions

Cocaine affects the reaction [NTRK2 protein affects the expression of KCNJ4 mRNA]

NCBI chr22:38,426,327...38,455,199
Ensembl chr22:38,426,327...38,455,199

G

potassium inwardly rectifying channel subfamily J member 6

affects expression
increases expression
decreases expression

Cocaine affects the expression of KCNJ6 mRNA
Cocaine results in increased expression of KCNJ6 mRNA
Cocaine results in decreased expression of KCNJ6 mRNA

PMID:12629581 PMID:17898221 PMID:20187946

NCBI chr21:37,607,373...37,916,457
Ensembl chr21:37,607,373...38,121,345

G

potassium inwardly rectifying channel subfamily J member 8

multiple interactions

Cocaine affects the reaction [NTRK2 protein affects the expression of KCNJ8 mRNA]

NCBI chr12:21,764,955...21,774,706
Ensembl chr12:21,764,955...21,775,600

G

potassium two pore domain channel subfamily K member 4

multiple interactions

HDAC5 affects the reaction [Cocaine affects the expression of KCNK4 mRNA]

NCBI chr11:64,291,302...64,300,031
Ensembl chr11:64,291,302...64,300,031

G

potassium voltage-gated channel subfamily Q member 5

multiple interactions

HDAC5 affects the reaction [Cocaine affects the expression of KCNQ5 mRNA]

NCBI chr 6:72,622,064...73,198,853
Ensembl chr 6:72,621,792...73,198,853

G

potassium sodium-activated channel subfamily T member 1

increases expression
multiple interactions

Cocaine results in increased expression of KCNT1 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of KCNT1 mRNA]

NCBI chr 9:135,702,185...135,795,502
Ensembl chr 9:135,702,185...135,795,508

G

lysine demethylase 3A

increases expression
multiple interactions

Cocaine results in increased expression of KDM3A mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of KDM3A mRNA]

NCBI chr 2:86,437,044...86,492,716
Ensembl chr 2:86,440,647...86,492,716

G

KH RNA binding domain containing, signal transduction associated 1

affects expression

Cocaine affects the expression of KHDRBS1 mRNA

NCBI chr 1:32,013,868...32,060,850
Ensembl chr 1:32,013,868...32,060,850

G

kinase D interacting substrate 220

affects expression

Cocaine affects the expression of KIDINS220 mRNA

NCBI chr 2:8,721,081...8,837,613
Ensembl chr 2:8,721,081...8,837,630

G

kinesin family member 3A

increases expression

Cocaine results in increased expression of KIF3A mRNA; Cocaine results in increased expression of KIF3A protein

PMID:17898221 PMID:25100957

NCBI chr 5:132,688,812...132,737,546
Ensembl chr 5:132,692,628...132,737,638

G

kinesin family member C1

affects expression

Cocaine affects the expression of KIFC1 mRNA

NCBI chr 6:33,391,461...33,409,896
Ensembl chr 6:33,391,823...33,409,896

G

kirre like nephrin family adhesion molecule 3

increases expression

Cocaine results in increased expression of KIRREL3 mRNA

NCBI chr11:126,423,358...127,000,870
Ensembl chr11:126,423,358...127,003,460

G

klotho

increases expression

Cocaine results in increased expression of KL mRNA

NCBI chr13:33,016,243...33,066,143
Ensembl chr13:33,016,423...33,066,143

G

KLF transcription factor 4

affects expression

Cocaine affects the expression of KLF4 mRNA

NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482

G

KLF transcription factor 5

affects expression

Cocaine affects the expression of KLF5 mRNA

NCBI chr13:73,054,976...73,077,538
Ensembl chr13:73,054,976...73,077,541

G

kelch domain containing 3

affects expression

Cocaine affects the expression of KLHDC3 mRNA

NCBI chr 6:43,014,249...43,021,294
Ensembl chr 6:43,014,103...43,021,298

G

kelch domain containing 7A

decreases expression

Cocaine results in decreased expression of KLHDC7A mRNA

NCBI chr 1:18,480,930...18,485,974
Ensembl chr 1:18,480,930...18,485,974

G

kelch like family member 12

affects expression

Cocaine affects the expression of KLHL12 mRNA

NCBI chr 1:202,891,120...202,928,599
Ensembl chr 1:202,891,116...202,928,636

G

kelch like family member 5

affects response to substance

KLHL5 gene SNP affects the susceptibility to Cocaine

NCBI chr 4:39,044,827...39,143,101
Ensembl chr 4:39,045,039...39,126,857

G

lysine methyltransferase 2E (inactive)

affects expression

Cocaine affects the expression of KMT2E mRNA

NCBI chr 7:105,014,205...105,115,019
Ensembl chr 7:104,940,943...105,115,019

G

karyopherin subunit beta 1

affects expression

Cocaine affects the expression of KPNB1 mRNA

NCBI chr17:47,649,919...47,685,505
Ensembl chr17:47,649,476...47,685,505

G

KRIT1 ankyrin repeat containing

increases expression

Cocaine results in increased expression of KRIT1 mRNA

NCBI chr 7:92,198,969...92,246,100
Ensembl chr 7:92,197,498...92,246,166

G

keratin 15

affects expression

Cocaine affects the expression of KRT15 mRNA

NCBI chr17:41,513,745...41,518,890
Ensembl chr17:41,513,745...41,522,529

G

kyphoscoliosis peptidase

decreases expression

Cocaine results in decreased expression of KY mRNA

NCBI chr 3:134,599,923...134,651,022
Ensembl chr 3:134,599,923...134,651,636

G

laminin subunit beta 1

increases expression

Cocaine results in increased expression of LAMB1 mRNA

NCBI chr 7:107,923,799...108,003,161
Ensembl chr 7:107,923,799...108,003,213

G

lysosomal associated membrane protein 2

increases expression

Cocaine results in increased expression of LAMP2 protein

NCBI chr X:120,426,148...120,469,349
Ensembl chr X:120,426,148...120,469,365

G

LARGE xylosyl- and glucuronyltransferase 1

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in increased expression of LARGE1 mRNA

NCBI chr22:33,066,663...33,922,824
Ensembl chr22:33,162,226...33,922,841

G

LIM domain binding 2

decreases expression

Cocaine results in decreased expression of LDB2 mRNA

NCBI chr 4:16,501,541...16,898,645
Ensembl chr 4:16,501,541...16,898,678

G

lactate dehydrogenase B

affects expression

Cocaine affects the expression of LDHB mRNA

NCBI chr12:21,635,342...21,657,842
Ensembl chr12:21,635,342...21,757,857

G

lactate dehydrogenase D

affects expression

Cocaine affects the expression of LDHD mRNA

NCBI chr16:75,111,864...75,116,780
Ensembl chr16:75,111,860...75,116,780

G

LEM domain containing 3

increases expression

Cocaine results in increased expression of MAN1 mRNA

NCBI chr12:65,169,583...65,248,355
Ensembl chr12:65,169,583...65,248,355

G

leucine rich repeat containing G protein-coupled receptor 5

decreases expression

Cocaine results in decreased expression of LGR5 mRNA

NCBI chr12:71,439,129...71,586,310
Ensembl chr12:71,439,798...71,586,310

G

luteinizing hormone subunit beta

increases secretion

Cocaine results in increased secretion of LHB protein

NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091

G

LIM zinc finger domain containing 2

affects expression

Cocaine affects the expression of LIMS2 mRNA

NCBI chr 2:127,638,426...127,681,786
Ensembl chr 2:127,638,381...127,681,786

G

lin-7 homolog B, crumbs cell polarity complex component

increases expression
multiple interactions

Cocaine results in increased expression of LIN7B mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of LIN7B mRNA]

NCBI chr19:49,114,370...49,118,460
Ensembl chr19:49,114,324...49,118,460

G

lin-7 homolog C, crumbs cell polarity complex component

increases expression

Cocaine results in increased expression of LIN7C mRNA

NCBI chr11:27,494,418...27,506,769
Ensembl chr11:27,494,418...27,506,769

G

LIM domain 7

increases expression

Cocaine results in increased expression of LMO7 mRNA

NCBI chr13:75,620,434...75,859,870
Ensembl chr13:75,620,434...75,859,870

G

LON peptidase N-terminal domain and ring finger 3

increases expression

Cocaine results in increased expression of LONRF3 mRNA

NCBI chr X:118,974,614...119,018,355
Ensembl chr X:118,974,614...119,018,355

G

lysyl oxidase

decreases expression

Cocaine results in decreased expression of LOX mRNA

NCBI chr 5:122,063,195...122,078,259
Ensembl chr 5:122,063,195...122,078,413

G

lysophosphatidic acid receptor 1

decreases expression

Cocaine results in decreased expression of LPAR1 mRNA

NCBI chr 9:110,873,263...111,038,998
Ensembl chr 9:110,873,263...111,038,470

G

leucine rich repeat containing 27

decreases expression

Cocaine results in decreased expression of LRRC27 mRNA

NCBI chr10:132,330,063...132,381,508
Ensembl chr10:132,332,154...132,381,508

G

leucine rich repeat containing 7

affects response to substance

LRRC7 gene SNP affects the susceptibility to Cocaine

NCBI chr 1:69,567,922...70,144,364
Ensembl chr 1:69,567,922...70,151,945

G

LRR binding FLII interacting protein 1

increases expression

Cocaine results in increased expression of LRRFIP1 mRNA

NCBI chr 2:237,627,587...237,781,643
Ensembl chr 2:237,627,587...237,813,682

G

leucine rich repeat neuronal 1

affects expression

Cocaine affects the expression of LRRN1 mRNA

NCBI chr 3:3,799,431...3,849,834
Ensembl chr 3:3,799,431...3,849,834

G

limbic system associated membrane protein

increases expression

Cocaine results in increased expression of LSAMP mRNA

NCBI chr 3:115,802,374...116,445,487
Ensembl chr 3:115,802,374...117,139,389

G

lymphocyte specific protein 1

decreases expression

Cocaine results in decreased expression of LSP1 mRNA

NCBI chr11:1,853,084...1,892,263
Ensembl chr11:1,850,904...1,892,267

G

lymphotoxin beta receptor

affects expression

Cocaine affects the expression of LTBR mRNA

NCBI chr12:6,375,160...6,391,566
Ensembl chr12:6,375,045...6,391,571

G

lymphocyte antigen 6 family member H

increases expression

Cocaine results in increased expression of LY6H protein

NCBI chr 8:143,157,916...143,160,654
Ensembl chr 8:143,157,914...143,160,711

G

leucine zipper tumor suppressor family member 3

increases expression
multiple interactions

Cocaine results in increased expression of LZTS3 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of LZTS3 mRNA]

NCBI chr20:3,162,617...3,173,549
Ensembl chr20:3,162,617...3,173,549

G

mab-21 like 2

decreases expression

Cocaine results in decreased expression of MAB21L2 mRNA

NCBI chr 4:150,582,151...150,584,693
Ensembl chr 4:150,582,151...150,584,693

G

MAF bZIP transcription factor F

increases expression

Cocaine results in increased expression of MAFF mRNA

NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507

G

MAGE family member D1

affects expression

Cocaine affects the expression of MAGED1 mRNA

NCBI chr X:51,803,076...51,902,354
Ensembl chr X:51,803,007...51,902,354

G

mal, T cell differentiation protein 2

increases expression

Cocaine results in increased expression of MAL2 mRNA

NCBI chr 8:119,208,363...119,245,673
Ensembl chr 8:119,165,034...119,245,673

G

mannosidase endo-alpha

affects response to substance

MANEA gene SNP affects the susceptibility to Cocaine

NCBI chr 6:95,577,535...95,609,452
Ensembl chr 6:95,577,485...95,609,470

G

monoamine oxidase A

multiple interactions

[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]

NCBI chr X:43,655,006...43,746,817
Ensembl chr X:43,654,907...43,746,817

G

monoamine oxidase B

multiple interactions

[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]

NCBI chr X:43,766,610...43,882,450
Ensembl chr X:43,766,610...43,882,450

G

microtubule associated protein 1A

increases expression

Cocaine results in increased expression of MAP1A mRNA

NCBI chr15:43,510,954...43,531,611
Ensembl chr15:43,510,958...43,531,620

G

microtubule associated protein 1B

affects expression
decreases expression

Cocaine affects the expression of MAP1B mRNA
Cocaine results in decreased expression of MAP1B mRNA

PMID:12629581 PMID:20187946

NCBI chr 5:72,107,475...72,209,565
Ensembl chr 5:72,107,234...72,209,565

G

microtubule associated protein 1 light chain 3 alpha

affects expression

Cocaine affects the expression of MAP1LC3A mRNA

NCBI chr20:34,546,844...34,560,345
Ensembl chr20:34,546,854...34,560,345

G

microtubule associated protein 2

affects expression
decreases expression

Cocaine affects the expression of MAP2 mRNA
Cocaine results in decreased expression of MAP2 mRNA

PMID:16076954 PMID:20187946

NCBI chr 2:209,424,047...209,734,112
Ensembl chr 2:209,424,047...209,734,147

G

mitogen-activated protein kinase kinase 1

decreases expression
multiple interactions
increases phosphorylation

Cocaine results in decreased expression of MAP2K1 mRNA
CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K1 protein]

PMID:12629581 PMID:15665076

NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656

G

mitogen-activated protein kinase kinase 2

multiple interactions
increases phosphorylation

CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K2 protein]

NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122

G

mitogen-activated protein kinase kinase 4

increases expression

Cocaine results in increased expression of MAP2K4 mRNA

NCBI chr17:12,020,877...12,143,828
Ensembl chr17:12,020,829...12,143,830

G

microtubule associated protein 6

affects expression

Cocaine affects the expression of MAP6 mRNA

NCBI chr11:75,586,918...75,669,038
Ensembl chr11:75,586,918...75,669,038

G

mitogen-activated protein kinase 1

multiple interactions
increases expression
increases phosphorylation
decreases activity
affects phosphorylation
increases activity

1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]
Cocaine results in increased expression of MAPK1 protein
Cocaine results in increased phosphorylation of MAPK1 protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Cocaine results in increased expression of MAPK1 protein]; Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein; ifenprodil inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Cocaine results in decreased activity of MAPK1 protein
Cocaine affects the phosphorylation of MAPK1 protein
Cocaine results in increased activity of MAPK1 protein
[[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of NEO1 protein; [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of PDYN protein; [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of SYT7 protein; [Cocaine co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased phosphorylation of MAPK1 protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; AG 1879 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAPK1 protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cocaine promotes the reaction [DRD1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cocaine promotes the reaction [DRD3 protein results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Cocaine results in increased phosphorylation of and results in increased localization of MAPK1 protein; DRD1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; GAL protein inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; resveratrol promotes the reaction [Cocaine results in increased phosphorylation of MAPK1 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]

PMID:15056714 PMID:15365088 PMID:15470197 PMID:15657599 PMID:15665076 More...

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 10

decreases expression

Cocaine results in decreased expression of MAPK10 mRNA

NCBI chr 4:86,010,405...86,594,074
Ensembl chr 4:85,990,007...86,594,625

G

mitogen-activated protein kinase 11

decreases expression
multiple interactions

Cocaine results in decreased expression of MAPK11 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of MAPK11 mRNA]

NCBI chr22:50,263,713...50,270,380
Ensembl chr22:50,263,713...50,270,767

G

mitogen-activated protein kinase 14

increases activity

Cocaine results in increased activity of MAPK14 protein

NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236

G

mitogen-activated protein kinase 3

increases expression
increases phosphorylation
affects phosphorylation
decreases activity
multiple interactions
decreases response to substance
increases activity

Cocaine results in increased expression of MAPK3 mRNA
Cocaine results in increased expression of MAPK3 protein
Cocaine results in increased phosphorylation of MAPK3 protein
Cocaine affects the phosphorylation of MAPK3 protein
Cocaine results in decreased activity of MAPK3 protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Cocaine results in increased expression of MAPK3 protein]; Cocaine affects the phosphorylation of and affects the activity of MAPK3 protein; Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein; ifenprodil inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
MAPK3 protein results in decreased susceptibility to Cocaine
Cocaine results in increased activity of MAPK3 protein
[Cocaine co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased phosphorylation of MAPK3 protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOS protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; AG 1879 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAPK3 protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cocaine promotes the reaction [DRD1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cocaine promotes the reaction [DRD3 protein results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Cocaine results in increased phosphorylation of and results in increased localization of MAPK3 protein; DRD1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; GAL protein inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]

PMID:12629581 PMID:15056714 PMID:15365088 PMID:15470197 PMID:15657599 More...

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

multiple interactions

acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; AG 1879 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 8 interacting protein 3

affects expression

Cocaine affects the expression of MAPK8IP3 mRNA

NCBI chr16:1,706,195...1,770,351
Ensembl chr16:1,706,166...1,770,351

G

membrane associated ring-CH-type finger 7

increases expression

Cocaine results in increased expression of MARCHF7 mRNA

NCBI chr 2:159,712,506...159,771,027
Ensembl chr 2:159,712,457...159,771,027

G

MARCKS like 1

affects expression

Cocaine affects the expression of MARCKSL1 mRNA

NCBI chr 1:32,333,839...32,336,233
Ensembl chr 1:32,333,839...32,336,233

G

microtubule affinity regulating kinase 1

affects expression

Cocaine affects the expression of MARK1 mRNA

NCBI chr 1:220,528,136...220,664,461
Ensembl chr 1:220,528,136...220,664,461

G

methionine adenosyltransferase 2A

affects expression

Cocaine affects the expression of MAT2A mRNA

NCBI chr 2:85,539,168...85,545,281
Ensembl chr 2:85,539,168...85,545,281

G

methyl-CpG binding domain protein 1

increases expression

Cocaine results in increased expression of MBD1 protein

NCBI chr18:50,266,885...50,281,767
Ensembl chr18:50,266,882...50,281,774

G

myelin basic protein

decreases expression

Cocaine results in decreased expression of MBP mRNA; Cocaine results in decreased expression of MBP protein

PMID:15009677 PMID:19217266

NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683

G

malate dehydrogenase 1

decreases expression

Cocaine results in decreased expression of MDH1 mRNA

NCBI chr 2:63,588,963...63,607,197
Ensembl chr 2:63,588,609...63,607,197

G

methyl-CpG binding protein 2

multiple interactions
increases expression

MECP2 mRNA inhibits the reaction [Cocaine results in increased expression of MIR132 protein]; MECP2 mRNA inhibits the reaction [Cocaine results in increased expression of MIR212 protein]
Cocaine inhibits the reaction [MECP2 protein binds to BDNF promoter]
Cocaine results in increased expression of MECP2 protein
Cocaine affects the reaction [MECP2 protein affects the expression of BDNF protein]; Cocaine affects the reaction [MECP2 protein binds to and results in decreased activity of BDNF promoter]

PMID:16670375 PMID:20711185 PMID:20810894 PMID:24358339

NCBI chr X:154,021,573...154,097,717
Ensembl chr X:154,021,573...154,137,103

G

myocyte enhancer factor 2A

increases expression

Cocaine results in increased expression of MEF2A mRNA

NCBI chr15:99,565,417...99,716,488
Ensembl chr15:99,565,417...99,716,488

G

myocyte enhancer factor 2D

decreases expression
multiple interactions

Cocaine results in decreased expression of MEF2D mRNA
Cocaine deficiency promotes the reaction [SMARCA4 protein binds to MEF2D promoter]

PMID:18000554 PMID:27422367

NCBI chr 1:156,463,727...156,500,775
Ensembl chr 1:156,463,727...156,500,779

G

multiple EGF like domains 10

increases expression

Cocaine results in increased expression of MEGF10 mRNA

NCBI chr 5:127,229,300...127,461,222
Ensembl chr 5:127,290,796...127,465,737

G

methylphosphate capping enzyme

increases expression
multiple interactions

Cocaine results in increased expression of MEPCE mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of MEPCE mRNA]

NCBI chr 7:100,428,790...100,434,118
Ensembl chr 7:100,428,322...100,434,126

G

MET proto-oncogene, receptor tyrosine kinase

affects expression

Cocaine affects the expression of MET mRNA

NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377

G

methyltransferase like 26

affects expression

Cocaine affects the expression of METTL26 mRNA

NCBI chr16:634,430...636,305
Ensembl chr16:634,427...636,366

G

mitochondrial fission factor

affects expression

Cocaine affects the expression of MFF mRNA

NCBI chr 2:227,325,251...227,357,836
Ensembl chr 2:227,325,151...227,357,833

G

monoglyceride lipase

affects expression

Cocaine affects the expression of MGLL mRNA

NCBI chr 3:127,689,066...127,823,185
Ensembl chr 3:127,689,062...128,052,190

G

MIA SH3 domain containing

increases expression

Cocaine results in increased expression of MIA mRNA

NCBI chr19:40,775,160...40,777,490
Ensembl chr19:40,771,648...40,777,490

G

microRNA 130a

increases expression
multiple interactions

Cocaine results in increased expression of MIR130A mRNA
AGO2 protein affects the reaction [Cocaine results in increased expression of MIR130A mRNA]

NCBI chr11:57,641,198...57,641,286
Ensembl chr11:57,641,198...57,641,286

G

microRNA 132

multiple interactions
increases expression

MECP2 mRNA inhibits the reaction [Cocaine results in increased expression of MIR132 protein]

NCBI chr17:2,049,908...2,050,008
Ensembl chr17:2,049,908...2,050,008

G

microRNA 136

multiple interactions
increases expression

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR136 mRNA]

NCBI chr14:100,884,702...100,884,783
Ensembl chr14:100,884,702...100,884,783

G

microRNA 137

multiple interactions
increases expression

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR137 mRNA]

NCBI chr 1:98,046,070...98,046,171
Ensembl chr 1:98,046,070...98,046,171

G

microRNA 138-1

multiple interactions
increases expression

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR138-1 mRNA]

NCBI chr 3:44,114,212...44,114,310
Ensembl chr 3:44,114,212...44,114,310

G

microRNA 148b

multiple interactions
increases expression

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR148B mRNA]

NCBI chr12:54,337,216...54,337,314
Ensembl chr12:54,337,216...54,337,314

G

microRNA 154

multiple interactions
increases expression

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR154 mRNA]

NCBI chr14:101,059,755...101,059,838
Ensembl chr14:101,059,755...101,059,838

G

microRNA 181a-1

increases expression
multiple interactions

Cocaine results in increased expression of MIR181A1 mRNA
AGO2 protein affects the reaction [Cocaine results in increased expression of MIR181A1 mRNA]

NCBI chr 1:198,859,044...198,859,153
Ensembl chr 1:198,859,044...198,859,153

G

microRNA 186

increases expression
multiple interactions

Cocaine results in increased expression of MIR186 mRNA
AGO2 protein affects the reaction [Cocaine results in increased expression of MIR186 mRNA]

NCBI chr 1:71,067,631...71,067,716
Ensembl chr 1:71,067,631...71,067,716

G

microRNA 212

multiple interactions
increases expression

MECP2 mRNA inhibits the reaction [Cocaine results in increased expression of MIR212 protein]
Cocaine results in increased expression of MIR212 mRNA; Cocaine results in increased expression of MIR212 protein
[[Cocaine results in increased expression of MIR212 mRNA] which results in increased activity of RAF1 protein] which results in increased expression of CRTC1 protein; [Cocaine results in increased expression of MIR212 mRNA] which results in increased activity of RAF1 protein; Cocaine affects the reaction [MIR212 protein affects the expression of BDNF protein]

PMID:20613834 PMID:20711185

NCBI chr17:2,050,271...2,050,380
Ensembl chr17:2,050,271...2,050,380

G

microRNA 301b

multiple interactions
increases expression

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR301B mRNA]

NCBI chr22:21,652,981...21,653,058
Ensembl chr22:21,652,981...21,653,058

G

microRNA 324

increases expression
multiple interactions

Cocaine results in increased expression of MIR324 mRNA
AGO2 protein affects the reaction [Cocaine results in increased expression of MIR324 mRNA]

NCBI chr17:7,223,297...7,223,379
Ensembl chr17:7,223,297...7,223,379

G

microRNA 337

increases expression
multiple interactions

Cocaine results in increased expression of MIR337 mRNA
AGO2 protein affects the reaction [Cocaine results in increased expression of MIR337 mRNA]

NCBI chr14:100,874,493...100,874,585
Ensembl chr14:100,874,493...100,874,585

G

microRNA 369

increases expression
multiple interactions

Cocaine results in increased expression of MIR369 mRNA
AGO2 protein affects the reaction [Cocaine results in increased expression of MIR369 mRNA]

NCBI chr14:101,065,598...101,065,667
Ensembl chr14:101,065,598...101,065,667

G

microRNA 376a-1

multiple interactions
increases expression

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR376A mRNA]

NCBI chr14:101,040,782...101,040,849
Ensembl chr14:101,040,782...101,040,849

G

microRNA 376c

multiple interactions
increases expression

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR376C mRNA]

NCBI chr14:101,039,690...101,039,755
Ensembl chr14:101,039,690...101,039,755

G

microRNA 380

increases expression
multiple interactions

Cocaine results in increased expression of MIR380 mRNA
AGO2 protein affects the reaction [Cocaine results in increased expression of MIR380 mRNA]

NCBI chr14:101,025,017...101,025,077
Ensembl chr14:101,025,017...101,025,077

G

microRNA 384

multiple interactions
increases expression

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR384 mRNA]

NCBI chr X:76,919,273...76,919,360
Ensembl chr X:76,919,273...76,919,360

G

microRNA 488

multiple interactions
increases expression

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR488 mRNA]

NCBI chr 1:177,029,363...177,029,445
Ensembl chr 1:177,029,363...177,029,445

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microRNA 502

multiple interactions
increases expression

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR500 mRNA]

NCBI chr X:50,014,598...50,014,683
Ensembl chr X:50,014,598...50,014,683

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microRNA 544a

increases expression
multiple interactions

Cocaine results in increased expression of MIR544 mRNA
AGO2 protein affects the reaction [Cocaine results in increased expression of MIR544 mRNA]

NCBI chr14:101,048,658...101,048,748
Ensembl chr14:101,048,658...101,048,748

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microRNA 665

increases expression
multiple interactions

Cocaine results in increased expression of MIR665 mRNA
AGO2 protein affects the reaction [Cocaine results in increased expression of MIR665 mRNA]

NCBI chr14:100,875,033...100,875,104
Ensembl chr14:100,875,033...100,875,104

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membrane metalloendopeptidase

multiple interactions

[Thiorphan binds to and results in decreased activity of MME protein] which results in increased susceptibility to Cocaine; naltrindole inhibits the reaction [[Thiorphan binds to and results in decreased activity of MME protein] which results in increased susceptibility to Cocaine]

NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704

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matrix metallopeptidase 13

decreases expression

Cocaine results in decreased expression of MMP13 mRNA

NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732

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matrix metallopeptidase 14

affects expression

Cocaine affects the expression of MMP14 mRNA

NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,041

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matrix metallopeptidase 23B

affects expression
increases expression

Cocaine affects the expression of MMP23 mRNA
Cocaine results in increased expression of MMP23 mRNA

PMID:17898221 PMID:20187946

NCBI chr 1:1,632,173...1,634,654
Ensembl chr 1:1,632,163...1,635,263

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matrix metallopeptidase 9

multiple interactions
increases expression

Cocaine results in decreased expression of and results in decreased activity of MMP9 protein
Cocaine results in increased expression of MMP9 mRNA

PMID:18000554 PMID:27899881

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

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myelin associated oligodendrocyte basic protein

affects expression

Cocaine affects the expression of MOBP mRNA

NCBI chr 3:39,467,680...39,529,497
Ensembl chr 3:39,467,198...39,529,479

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mitochondrial pyruvate carrier 2

increases expression

Cocaine results in increased expression of MPC2 protein

NCBI chr 1:167,916,675...167,937,072
Ensembl chr 1:167,916,675...167,937,072

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myeloperoxidase

increases activity

Cocaine results in increased activity of MPO protein

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

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major histocompatibility complex, class I-related

increases expression

Cocaine results in increased expression of MR1 mRNA

NCBI chr 1:181,033,387...181,061,938
Ensembl chr 1:181,033,374...181,061,938

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muscle RAS oncogene homolog

affects expression

Cocaine affects the expression of MRAS mRNA

NCBI chr 3:138,347,648...138,405,535
Ensembl chr 3:138,347,648...138,405,534

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mannose receptor C-type 1

decreases expression

Cocaine results in decreased expression of MRC1 mRNA

NCBI chr10:17,809,348...17,911,164
Ensembl chr10:17,809,348...17,911,164

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mitochondrial rRNA methyltransferase 2

increases expression

Cocaine results in increased expression of MRM2 mRNA

NCBI chr 7:2,234,195...2,242,205
Ensembl chr 7:2,234,195...2,242,205

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mitochondrial ribosomal protein L17

affects expression
increases expression

Cocaine affects the expression of MRPL17 mRNA
Cocaine results in increased expression of MRPL17 mRNA

PMID:17898221 PMID:18355967

NCBI chr11:6,680,385...6,683,340
Ensembl chr11:6,680,385...6,683,340

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membrane spanning 4-domains A14

affects expression

Cocaine affects the expression of MS4A14 mRNA

NCBI chr11:60,396,459...60,417,756
Ensembl chr11:60,378,530...60,417,756

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methionine sulfoxide reductase B2

affects expression

Cocaine affects the expression of MSRB2 mRNA

NCBI chr10:23,095,579...23,122,013
Ensembl chr10:23,095,579...23,122,013

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mitochondrially encoded cytochrome c oxidase I

increases expression

Cocaine results in increased expression of COX1 protein

NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445

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mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4

increases expression

Cocaine results in increased expression of ND4 protein

NCBI chr MT:10,760...12,137
Ensembl chr MT:10,760...12,137

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mitochondrial fission process 1

affects expression

Cocaine affects the expression of MTFP1 mRNA

NCBI chr22:30,425,768...30,429,054
Ensembl chr22:30,425,623...30,429,054

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myotrophin

affects expression

Cocaine affects the expression of MTPN mRNA

NCBI chr 7:135,926,760...135,977,359
Ensembl chr 7:135,926,760...135,977,359

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microtubule associated scaffold protein 1

decreases expression

Cocaine results in decreased expression of MTUS1 mRNA

NCBI chr 8:17,643,802...17,801,521
Ensembl chr 8:17,643,795...17,801,094

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muscle associated receptor tyrosine kinase

affects expression

Cocaine affects the expression of MUSK mRNA

NCBI chr 9:110,668,791...110,806,558
Ensembl chr 9:110,668,779...110,806,558

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MAX dimerization protein 1

increases expression

Cocaine results in increased expression of MXD1 mRNA

NCBI chr 2:69,915,109...69,942,945
Ensembl chr 2:69,897,688...69,942,945

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MYG1 exonuclease

affects expression

Cocaine affects the expression of MYG1 mRNA

NCBI chr12:53,299,695...53,307,177
Ensembl chr12:53,299,695...53,307,177

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myosin heavy chain 6

decreases expression

Cocaine results in decreased expression of MYH6 mRNA

NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273

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myosin heavy chain 7

increases expression

Cocaine results in increased expression of MYH7 mRNA

NCBI chr14:23,412,740...23,435,660
Ensembl chr14:23,412,740...23,435,660

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myosin heavy chain 9

affects expression

Cocaine affects the expression of MYH9 mRNA

NCBI chr22:36,281,280...36,387,967
Ensembl chr22:36,281,280...36,388,010

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myosin VA

increases expression

Cocaine results in increased expression of MYO5A mRNA

NCBI chr15:52,307,283...52,529,050
Ensembl chr15:52,307,281...52,529,132

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myomesin 1

affects expression

Cocaine affects the expression of MYOM1 mRNA

NCBI chr18:3,066,807...3,247,376
Ensembl chr18:3,066,807...3,219,968

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N-alpha-acetyltransferase 15, NatA auxiliary subunit

increases expression

Cocaine results in increased expression of NAA15 mRNA

NCBI chr 4:139,301,505...139,391,384
Ensembl chr 4:139,301,446...139,420,033

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nucleus accumbens associated 1

affects response to substance
increases expression

NACC1 protein affects the susceptibility to Cocaine
Cocaine results in increased expression of NACC1 mRNA; Cocaine results in increased expression of NACC1 protein alternative form

PMID:10934270 PMID:11906783 PMID:17945361

NCBI chr19:13,116,852...13,141,147
Ensembl chr19:13,116,862...13,141,147

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NACC family member 2

affects expression

Cocaine affects the expression of NACC2 mRNA

NCBI chr 9:136,006,537...136,095,289
Ensembl chr 9:136,006,537...136,095,289

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NALCN channel auxiliary factor 1

increases expression

Cocaine results in increased expression of NALF1 mRNA

NCBI chr13:107,163,510...107,867,496
Ensembl chr13:107,163,510...107,867,496

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NSF attachment protein alpha

affects expression

Cocaine affects the expression of NAPA mRNA

NCBI chr19:47,484,530...47,515,063
Ensembl chr19:47,487,637...47,515,091

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NSF attachment protein gamma

affects expression

Cocaine affects the expression of NAPG mRNA

NCBI chr18:10,526,027...10,552,764
Ensembl chr18:10,525,905...10,552,764

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nuclear prelamin A recognition factor

affects expression

Cocaine affects the expression of NARF mRNA

NCBI chr17:82,458,198...82,490,537
Ensembl chr17:82,458,180...82,490,537

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neurocalcin delta

decreases expression
multiple interactions

Cocaine results in decreased expression of NCALD mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of NCALD mRNA]

NCBI chr 8:101,686,542...102,124,907
Ensembl chr 8:101,686,542...102,124,907

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neurocan

affects expression

Cocaine affects the expression of NCAN mRNA

NCBI chr19:19,211,958...19,252,233
Ensembl chr19:19,211,958...19,252,233

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nuclear cap binding protein subunit 1

affects expression

Cocaine affects the expression of NCBP1 mRNA

NCBI chr 9:97,633,821...97,673,748
Ensembl chr 9:97,633,668...97,673,748

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neutrophil cytosolic factor 1

increases phosphorylation
multiple interactions
affects expression

Cocaine results in increased phosphorylation of NCF1 protein
Cocaine results in increased phosphorylation of and results in increased expression of NCF1 protein
Prazosin inhibits the reaction [Cocaine results in increased phosphorylation of NCF1 protein]
Cocaine affects the expression of NCF1 mRNA

PMID:15936005 PMID:18952886 PMID:20187946

NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315

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neutrophil cytosolic factor 2

increases expression

Cocaine results in increased expression of NCF2 protein

NCBI chr 1:183,555,562...183,601,849
Ensembl chr 1:183,554,461...183,590,905

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neutrophil cytosolic factor 4

increases expression

Cocaine results in increased expression of NCF4 protein

NCBI chr22:36,861,006...36,878,015
Ensembl chr22:36,860,988...36,878,017

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nuclear receptor coactivator 3

affects expression

Cocaine affects the expression of NCOA3 mRNA

NCBI chr20:47,501,887...47,656,872
Ensembl chr20:47,501,887...47,656,877

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neuronal calcium sensor 1

increases expression

Cocaine results in increased expression of NCS1 mRNA

NCBI chr 9:130,172,404...130,237,303
Ensembl chr 9:130,172,404...130,237,303

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neuron derived neurotrophic factor

decreases expression

Cocaine results in decreased expression of NDNF mRNA

NCBI chr 4:121,035,613...121,072,535
Ensembl chr 4:121,035,613...121,073,021

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NDRG family member 2

decreases expression

Cocaine results in decreased expression of NDRG2 mRNA

NCBI chr14:21,016,763...21,070,872
Ensembl chr14:21,016,763...21,070,872

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NADH:ubiquinone oxidoreductase subunit A10

affects expression

Cocaine affects the expression of NDUFA10 protein

NCBI chr 2:239,892,442...240,025,342
Ensembl chr 2:239,892,450...240,025,743

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NADH:ubiquinone oxidoreductase core subunit S2

affects expression

Cocaine affects the expression of NDUFS2 protein

NCBI chr 1:161,197,417...161,214,395
Ensembl chr 1:161,197,104...161,214,723

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NADH:ubiquinone oxidoreductase core subunit V2

affects expression

Cocaine affects the expression of NDUFV2 mRNA

NCBI chr18:9,102,699...9,134,341
Ensembl chr18:9,102,630...9,134,345

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nebulin

decreases expression

Cocaine results in decreased expression of NEB mRNA

NCBI chr 2:151,485,339...151,734,476
Ensembl chr 2:151,485,336...151,734,487

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N-terminal EF-hand calcium binding protein 2

affects expression
decreases expression

Cocaine affects the expression of NECAB2 mRNA
Cocaine results in decreased expression of NECAB2 protein

PMID:20187946 PMID:25100957

NCBI chr16:83,965,177...84,002,776
Ensembl chr16:83,968,244...84,002,776

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NEDD4 like E3 ubiquitin protein ligase

increases expression

Cocaine results in increased expression of NEDD4L mRNA

NCBI chr18:58,044,226...58,401,540
Ensembl chr18:58,044,226...58,401,540

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neurofilament heavy chain

increases expression

Cocaine results in increased expression of NEFH protein

NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390

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neurofilament light chain

affects expression
decreases expression

Cocaine affects the expression of NEFL mRNA
Cocaine results in decreased expression of NEFL mRNA

PMID:12629581 PMID:16076954 PMID:20187946

NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,956,721

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neurofilament medium chain

decreases expression

Cocaine results in decreased expression of NEFM mRNA

NCBI chr 8:24,913,761...24,919,093
Ensembl chr 8:24,913,758...24,919,098

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neogenin 1

multiple interactions

[[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of NEO1 protein; Cocaine promotes the reaction [DRD1 protein results in increased expression of NEO1 protein]; Cocaine promotes the reaction [DRD3 protein results in decreased expression of NEO1 protein]

NCBI chr15:73,051,692...73,305,206
Ensembl chr15:73,051,710...73,305,205

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neuropilin and tolloid like 2

increases expression

Cocaine results in increased expression of NETO2 mRNA

NCBI chr16:47,077,703...47,143,945
Ensembl chr16:47,077,703...47,143,945

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nexilin F-actin binding protein

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of NEXN mRNA

NCBI chr 1:77,888,624...77,943,895
Ensembl chr 1:77,888,513...77,943,895

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neurofibromin 1

increases expression

Cocaine results in increased expression of NF1 mRNA

NCBI chr17:31,094,927...31,377,677
Ensembl chr17:31,094,927...31,382,116

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NFE2 like bZIP transcription factor 1

increases expression

Cocaine results in increased expression of NFE2L1 mRNA

NCBI chr17:48,048,359...48,061,545
Ensembl chr17:48,048,329...48,061,545

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NFE2 like bZIP transcription factor 2

multiple interactions

Cocaine results in increased activity of and affects the localization of NFE2L2 protein; PRKCD protein affects the reaction [Cocaine results in increased activity of and affects the localization of NFE2L2 protein]; rottlerin promotes the reaction [Cocaine results in increased activity of and affects the localization of NFE2L2 protein]

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

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NFE2 like bZIP transcription factor 3

increases expression

Cocaine results in increased expression of NFE2L3 mRNA

NCBI chr 7:26,152,198...26,187,137
Ensembl chr 7:26,152,198...26,187,137

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nuclear factor kappa B subunit 1

affects expression

Cocaine affects the expression of NFKB1 mRNA

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

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nuclear factor kappa B subunit 2

affects expression

Cocaine affects the expression of NFKB2 mRNA

NCBI chr10:102,394,110...102,402,529
Ensembl chr10:102,394,110...102,402,524

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NFKB inhibitor alpha

increases phosphorylation
multiple interactions
increases activity
affects expression

Cocaine results in increased phosphorylation of NFKBIA protein
SCH 23390 inhibits the reaction [Cocaine results in increased activity of NFKBIA protein]
Cocaine affects the expression of NFKBIA mRNA

PMID:15681117 PMID:19183502 PMID:20187946 PMID:20354174

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

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NFKB inhibitor zeta

decreases expression

Cocaine results in decreased expression of NFKBIZ mRNA

NCBI chr 3:101,827,990...101,861,022
Ensembl chr 3:101,827,991...101,861,022

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NFU1 iron-sulfur cluster scaffold

increases expression

Cocaine results in increased expression of NFU1 mRNA

NCBI chr 2:69,395,750...69,439,567
Ensembl chr 2:69,396,113...69,437,628

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nuclear transcription factor Y subunit beta

increases expression

Cocaine results in increased expression of NFYB mRNA

NCBI chr12:104,117,086...104,138,210
Ensembl chr12:104,117,086...104,138,241

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nerve growth factor

decreases expression

Cocaine results in decreased expression of NGF protein

NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770

G

ninein like

decreases expression

Cocaine results in decreased expression of NLP mRNA

NCBI chr20:25,452,697...25,585,531
Ensembl chr20:25,451,594...25,585,531

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nitrilase family member 2

increases expression
multiple interactions

Cocaine results in increased expression of NIT2 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of NIT2 mRNA]

NCBI chr 3:100,334,757...100,361,635
Ensembl chr 3:100,334,739...100,361,635

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NK2 homeobox 2

decreases expression

Cocaine results in decreased expression of NKX2-2 mRNA

NCBI chr20:21,511,017...21,522,689
Ensembl chr20:21,511,017...21,514,064

G

NME/NM23 nucleoside diphosphate kinase 2

affects expression

Cocaine affects the expression of NME2 protein

NCBI chr17:51,165,536...51,171,744
Ensembl chr17:51,165,435...51,171,744

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NME/NM23 family member 7

affects expression

Cocaine affects the expression of NME7 mRNA

NCBI chr 1:169,132,531...169,367,797
Ensembl chr 1:169,132,531...169,367,948

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nitric oxide associated 1

affects expression

Cocaine affects the expression of NOA1 mRNA

NCBI chr 4:56,963,350...56,977,606
Ensembl chr 4:56,963,350...56,977,606

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nucleolar protein 12

affects expression

Cocaine affects the expression of NOL12 mRNA

NCBI chr22:37,686,343...37,693,474
Ensembl chr22:37,681,673...37,693,476

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non-POU domain containing octamer binding

affects expression

Cocaine affects the expression of NONO mRNA

NCBI chr X:71,283,635...71,301,168
Ensembl chr X:71,254,814...71,301,522

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nitric oxide synthase 1

affects response to substance
affects expression
increases activity

NOS1 protein affects the susceptibility to Cocaine
Cocaine affects the expression of NOS1 protein
Cocaine results in increased activity of NOS1 protein

PMID:11032893 PMID:16698049 PMID:20477932

NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170

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nitric oxide synthase 3

decreases expression
increases expression
decreases phosphorylation
multiple interactions

Cocaine results in decreased expression of NOS3 protein
Cocaine results in increased expression of NOS3 protein
Cocaine results in decreased phosphorylation of NOS3 protein
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of NOS3 mRNA]

PMID:17420087 PMID:18355967 PMID:18813882 PMID:19380615

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

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neuronal PAS domain protein 2

decreases expression
multiple interactions
increases expression
affects response to substance

Cocaine results in decreased expression of NPAS2 mRNA
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Cocaine results in increased splicing of NPAS2 mRNA]
Cocaine results in increased expression of NPAS2 mRNA
NPAS2 affects the susceptibility to Cocaine
Cocaine promotes the reaction [NPAS2 protein binds to PER1 promoter]; Cocaine promotes the reaction [NPAS2 protein binds to PER2 promoter]; Cocaine promotes the reaction [NPAS2 protein binds to PER3 promoter]

PMID:15994025 PMID:23776671 PMID:32312805

NCBI chr 2:100,818,723...100,996,829
Ensembl chr 2:100,820,139...100,996,829

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nuclear pore complex interacting protein family member B3

increases expression

Cocaine results in increased expression of NPIPB3 mRNA

NCBI chr16:21,402,129...21,425,378
Ensembl chr16:21,402,237...21,448,567

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natriuretic peptide A

increases expression

Cocaine results in increased expression of NPPA mRNA
Cocaine results in increased expression of NPPA protein

PMID:9455993 PMID:11377647

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

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natriuretic peptide C

multiple interactions

NPPC protein inhibits the reaction [Cocaine results in increased abundance of Dopamine]; NPPC protein inhibits the reaction [Cocaine results in increased expression of EGR1 mRNA]; NPPC protein inhibits the reaction [Cocaine results in increased expression of FOS mRNA]; NPPC protein inhibits the reaction [Cocaine results in increased expression of JUNB mRNA]

NCBI chr 2:231,921,809...231,926,396
Ensembl chr 2:231,921,809...231,926,396

G

NPR3 like, GATOR1 complex subunit

affects expression

Cocaine affects the expression of NPRL3 mRNA

NCBI chr16:85,386...138,673
Ensembl chr16:84,271...138,677

G

neuronal pentraxin 2

affects expression

Cocaine affects the expression of NPTX2 protein

NCBI chr 7:98,617,285...98,629,869
Ensembl chr 7:98,617,285...98,629,869

G

neuronal pentraxin receptor

decreases expression
multiple interactions

Cocaine results in decreased expression of NPTXR mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of NPTXR mRNA]

PMID:16076954 PMID:18355967

NCBI chr22:38,818,452...38,844,028
Ensembl chr22:38,818,452...38,844,028

G

neuropeptide Y

affects expression
decreases expression

Cocaine affects the expression of NPY mRNA
Cocaine results in decreased expression of NPY mRNA

PMID:16076954 PMID:17851536 PMID:20187946

NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

increases expression

Cocaine results in increased expression of NQO2 mRNA

NCBI chr 6:2,999,894...3,019,755
Ensembl chr 6:2,987,987...3,019,755

G

nuclear receptor subfamily 1 group I member 3

decreases expression

Cocaine results in decreased expression of NR1I3 mRNA

NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244

G

nuclear receptor subfamily 2 group F member 2

increases expression

Cocaine results in increased expression of NR2F2 mRNA

NCBI chr15:96,326,046...96,340,263
Ensembl chr15:96,325,938...96,340,263

G

nuclear receptor subfamily 3 group C member 1

increases response to substance
decreases expression

NR3C1 protein results in increased susceptibility to Cocaine
Cocaine results in decreased expression of NR3C1 mRNA
Cocaine results in decreased expression of NR3C1 protein

PMID:12805318 PMID:16188404 PMID:17689506 PMID:20948987

NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512

G

nuclear receptor subfamily 3 group C member 2

increases expression

Cocaine deficiency results in increased expression of NR3C2 mRNA

NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698

G

nuclear receptor subfamily 4 group A member 1

increases expression
affects expression

Cocaine results in increased expression of NR4A1 mRNA
Cocaine affects the expression of NR4A1 mRNA

PMID:12117546 PMID:12358776 PMID:17851536 PMID:20187946

NCBI chr12:52,022,832...52,059,503
Ensembl chr12:52,022,832...52,059,507

G

nuclear receptor subfamily 4 group A member 2

decreases expression

Cocaine results in decreased expression of NR4A2 protein

NCBI chr 2:156,324,437...156,332,721
Ensembl chr 2:156,324,437...156,342,348

G

nuclear receptor subfamily 4 group A member 3

increases expression

Cocaine results in increased expression of NR4A3 mRNA

NCBI chr 9:99,821,885...99,866,891
Ensembl chr 9:99,821,855...99,866,891

G

nuclear receptor interacting protein 3

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in increased expression of NRIP3 mRNA

NCBI chr11:8,980,576...9,004,505
Ensembl chr11:8,965,682...9,005,288

G

neuritin 1

decreases expression
multiple interactions

Cocaine results in decreased expression of NRN1 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of NRN1 mRNA]

NCBI chr 6:5,997,999...6,007,518
Ensembl chr 6:5,997,999...6,007,605

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neuropilin 1

increases expression

Cocaine results in increased expression of NRP1 mRNA

NCBI chr10:33,177,493...33,334,667
Ensembl chr10:33,177,492...33,336,262

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neuropilin 2

increases expression

Cocaine results in increased expression of NRP2 mRNA

NCBI chr 2:205,682,501...205,798,131
Ensembl chr 2:205,681,990...205,798,133

G

neurturin

affects expression

Cocaine affects the expression of NRTN mRNA

NCBI chr19:5,805,067...5,828,324
Ensembl chr19:5,805,067...5,828,324

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N-ethylmaleimide sensitive factor, vesicle fusing ATPase

decreases expression

Cocaine results in decreased expression of NSF mRNA

NCBI chr17:46,590,669...46,757,464
Ensembl chr17:46,590,669...46,757,679

G

netrin 1

decreases expression

Cocaine results in decreased expression of NTN1 mRNA

NCBI chr17:9,003,087...9,244,000
Ensembl chr17:9,021,510...9,244,000

G

neurotrophic receptor tyrosine kinase 2

multiple interactions
decreases phosphorylation
affects expression
decreases expression

Cocaine affects the reaction [NTRK2 protein affects the expression of KCNA2 mRNA]; Cocaine affects the reaction [NTRK2 protein affects the expression of KCNB1 mRNA]; Cocaine affects the reaction [NTRK2 protein affects the expression of KCND1 mRNA]; Cocaine affects the reaction [NTRK2 protein affects the expression of KCNJ4 mRNA]; Cocaine affects the reaction [NTRK2 protein affects the expression of KCNJ8 mRNA]; NTRK2 protein affects the reaction [Cocaine affects the expression of FOS protein]
Cocaine results in decreased phosphorylation of NTRK2 protein
Cocaine affects the expression of NTRK2 mRNA; Cocaine affects the expression of NTRK2 protein
Cocaine results in decreased expression of NTRK2 mRNA

PMID:12358776 PMID:15009677 PMID:16423334 PMID:16710320 PMID:20187946 More...

NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751

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neurotensin

increases expression
multiple interactions

Cocaine results in increased expression of NTS mRNA
NTS protein inhibits the reaction [Cocaine results in decreased secretion of gamma-Aminobutyric Acid]
DRD3 protein affects the reaction [Cocaine results in increased expression of NTS mRNA]

PMID:11120399 PMID:18252810 PMID:27899881

NCBI chr12:85,874,295...85,882,992
Ensembl chr12:85,874,295...85,882,992

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nuclear casein kinase and cyclin dependent kinase substrate 1

decreases expression

Cocaine results in decreased expression of NUCKS1 mRNA

PMID:15009677 PMID:16710320

NCBI chr 1:205,712,822...205,750,182
Ensembl chr 1:205,712,822...205,750,182

G

nucleoporin 188

affects expression

Cocaine affects the expression of NUP188 mRNA

NCBI chr 9:128,947,699...129,007,096
Ensembl chr 9:128,947,699...129,007,096

G

nucleoporin 88

affects expression

Cocaine affects the expression of NUP88 mRNA

NCBI chr17:5,384,833...5,419,662
Ensembl chr17:5,359,668...5,420,164

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nuclear protein 1, transcriptional regulator

affects expression

Cocaine affects the expression of NUPR1 mRNA

NCBI chr16:28,532,708...28,538,974
Ensembl chr16:28,532,708...28,539,008

G

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

affects expression

Cocaine affects the expression of OBSCN mRNA

NCBI chr 1:228,208,044...228,378,876
Ensembl chr 1:228,208,044...228,378,876

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obscurin like cytoskeletal adaptor 1

increases expression

Cocaine results in increased expression of OBSL1 mRNA

NCBI chr 2:219,547,206...219,571,539
Ensembl chr 2:219,550,728...219,571,859

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OCIA domain containing 2

increases expression

Cocaine results in increased expression of OCIAD2 protein

NCBI chr 4:48,885,019...48,906,828
Ensembl chr 4:48,885,019...48,906,937

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Obg like ATPase 1

affects expression

Cocaine affects the expression of OLA1 mRNA

NCBI chr 2:174,072,447...174,248,532
Ensembl chr 2:174,072,447...174,248,599

G

olfactomedin 1

affects expression

Cocaine affects the expression of OLFM1 mRNA

NCBI chr 9:135,075,505...135,121,184
Ensembl chr 9:135,075,422...135,121,180

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oligophrenin 1

increases expression

Cocaine results in increased expression of OPHN1 mRNA

NCBI chr X:68,042,344...68,433,841
Ensembl chr X:67,949,349...68,433,913

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opioid receptor delta 1

affects localization
multiple interactions

Cocaine affects the localization of OPRD1 protein
[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine; naltrindole inhibits the reaction [[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine]

PMID:18417105 PMID:19279569

NCBI chr 1:28,812,170...28,871,267
Ensembl chr 1:28,812,170...28,871,267

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opioid receptor kappa 1

multiple interactions
increases expression

[U 69593 binds to and results in increased activity of OPRK1 protein] inhibits the reaction [Cocaine affects the abundance of Dopamine]; Cocaine affects the reaction [enadoline binds to OPRK1 protein]
Cocaine deficiency results in increased expression of OPRK1 mRNA
Cocaine results in increased expression of OPRK1 protein

PMID:11113311 PMID:17621646 PMID:27126842

NCBI chr 8:53,225,724...53,251,637
Ensembl chr 8:53,225,724...53,251,637

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opioid receptor mu 1

multiple interactions
increases expression
decreases expression
affects expression
decreases response to substance
affects response to substance
increases response to substance
increases activity

Cocaine affects the reaction [carfentanil binds to OPRM1 protein]
Cocaine deficiency results in increased expression of OPRM1 mRNA
Cocaine results in decreased expression of OPRM1 mRNA
[CTAP octapeptide binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [POMC protein results in increased susceptibility to Cocaine]; [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein] which results in increased susceptibility to Cocaine; CTAP octapeptide inhibits the reaction [[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein] which results in increased susceptibility to Cocaine]
Cocaine affects the expression of OPRM1 mRNA; Cocaine affects the expression of OPRM1 protein
PDYN protein affects the reaction [Cocaine results in increased activity of OPRM1 protein]
OPRM1 gene mutant form results in decreased susceptibility to Cocaine; OPRM1 mutant form results in decreased susceptibility to Cocaine
OPRM1 protein affects the susceptibility to Cocaine
OPRM1 gene SNP results in increased susceptibility to Cocaine

PMID:10803207 PMID:10891866 PMID:12128154 PMID:12815747 PMID:15664692 More...

NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867

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oxysterol binding protein like 1A

decreases expression

Cocaine results in decreased expression of OSBPL1A mRNA

NCBI chr18:24,162,045...24,397,824
Ensembl chr18:24,162,045...24,397,880

G

otoferlin

decreases expression

Cocaine results in decreased expression of OTOF mRNA

NCBI chr 2:26,457,203...26,558,756
Ensembl chr 2:26,457,203...26,558,756

G

oxytocin receptor

affects expression
multiple interactions

Cocaine affects the expression of OXTR protein
Cocaine affects the reaction [vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 binds to OXTR protein]

NCBI chr 3:8,741,269...8,769,613
Ensembl chr 3:8,750,381...8,769,628

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proliferation-associated 2G4

increases expression

Cocaine results in increased expression of PA2G4 mRNA

NCBI chr12:56,104,559...56,113,910
Ensembl chr12:56,104,537...56,113,910

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poly(A) binding protein cytoplasmic 1

affects expression

Cocaine affects the expression of PABPC1 mRNA

NCBI chr 8:100,702,916...100,722,088
Ensembl chr 8:100,685,816...100,722,809

G

platelet activating factor acetylhydrolase 2

decreases expression

Cocaine results in decreased expression of PAFAH2 mRNA

NCBI chr 1:25,959,767...25,998,063
Ensembl chr 1:25,959,767...25,998,117

G

p21 (RAC1) activated kinase 6

decreases expression

Cocaine results in decreased expression of PAK6 mRNA

NCBI chr15:40,239,063...40,277,487
Ensembl chr15:40,217,428...40,277,487

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protein associated with LIN7 1, MAGUK p55 family member

increases expression

Cocaine results in increased expression of PALS1 mRNA

NCBI chr14:67,241,435...67,336,061
Ensembl chr14:67,240,713...67,336,061

G

progestin and adipoQ receptor family member 4

affects expression

Cocaine affects the expression of PAQR4 mRNA

NCBI chr16:2,969,348...2,973,484
Ensembl chr16:2,969,270...2,973,484

G

poly(ADP-ribose) polymerase 1

increases cleavage
affects expression

Cocaine results in increased cleavage of PARP1 protein
Cocaine affects the expression of PARP1 mRNA

PMID:15681117 PMID:17084983

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

parvin alpha

affects expression

Cocaine affects the expression of PARVA mRNA

NCBI chr11:12,376,436...12,535,356
Ensembl chr11:12,377,563...12,535,356

G

paired box 8

increases expression

Cocaine results in increased expression of PAX8 mRNA

NCBI chr 2:113,215,997...113,278,921
Ensembl chr 2:113,215,997...113,278,921

G

PBX homeobox 1

decreases expression
increases expression

Cocaine results in decreased expression of PBX1 mRNA
Cocaine results in increased expression of PBX1 mRNA

NCBI chr 1:164,559,184...164,886,047
Ensembl chr 1:164,555,584...164,899,296

G

PBX homeobox 2

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PBX2 mRNA

NCBI chr 6:32,184,733...32,190,202
Ensembl chr 6:32,184,733...32,190,202

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PBX homeobox 3

increases expression
multiple interactions

Cocaine results in increased expression of PBX3 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PBX3 mRNA]

NCBI chr 9:125,747,373...125,967,377
Ensembl chr 9:125,747,345...125,967,377

G

protocadherin 7

increases expression

Cocaine results in increased expression of PCDH7 mRNA

NCBI chr 4:30,720,369...31,146,800
Ensembl chr 4:30,720,369...31,146,805

G

protocadherin 8

increases expression

Cocaine results in increased expression of PCDH8 mRNA; Cocaine results in increased expression of PCDH8 protein

NCBI chr13:52,842,889...52,848,640
Ensembl chr13:52,842,889...52,848,641

G

protocadherin alpha 2

increases expression

Cocaine results in increased expression of PCDHA2 mRNA

NCBI chr 5:140,794,852...141,012,347
Ensembl chr 5:140,794,852...141,012,347

G

protocadherin gamma subfamily A, 1

increases expression

Cocaine results in increased expression of PCDHGA1 mRNA

NCBI chr 5:141,330,514...141,512,975
Ensembl chr 5:141,330,514...141,512,975

G

protocadherin gamma subfamily C, 3

affects expression

Cocaine affects the expression of PCDHGC3 mRNA

NCBI chr 5:141,475,966...141,512,975
Ensembl chr 5:141,475,947...141,512,977

G

Purkinje cell protein 4

decreases expression

Cocaine results in decreased expression of PCP4 mRNA

NCBI chr21:39,867,438...39,929,392
Ensembl chr21:39,867,438...39,929,397

G

proprotein convertase subtilisin/kexin type 1

increases expression

Cocaine results in increased expression of PCSK1 mRNA

NCBI chr 5:96,390,333...96,433,248
Ensembl chr 5:96,390,333...96,434,143

G

proprotein convertase subtilisin/kexin type 1 inhibitor

decreases expression

Cocaine results in decreased expression of PCSK1N mRNA

NCBI chr X:48,831,096...48,835,610
Ensembl chr X:48,831,096...48,835,610

G

proprotein convertase subtilisin/kexin type 2

decreases expression

Cocaine results in decreased expression of PCSK2 mRNA

NCBI chr20:17,226,107...17,484,578
Ensembl chr20:17,226,107...17,484,578

G

programmed cell death 11

increases expression

Cocaine results in increased expression of PDCD11 mRNA

NCBI chr10:103,396,626...103,446,294
Ensembl chr10:103,396,626...103,446,294

G

programmed cell death 5

affects expression

Cocaine affects the expression of PDCD5 mRNA

NCBI chr19:32,581,190...32,587,453
Ensembl chr19:32,581,190...32,587,453

G

programmed cell death 6

affects expression

Cocaine affects the expression of PDCD6 mRNA

NCBI chr 5:271,646...314,974
Ensembl chr 5:271,621...314,974

G

programmed cell death 7

increases expression

Cocaine results in increased expression of PDCD7 mRNA

NCBI chr15:65,117,379...65,133,808
Ensembl chr15:65,117,379...65,133,808

G

phosphodiesterase 10A

increases expression

Cocaine deficiency results in increased expression of PDE10A mRNA

NCBI chr 6:165,327,289...165,988,052
Ensembl chr 6:165,327,287...165,988,117

G

phosphodiesterase 4D interacting protein

decreases expression

Cocaine results in decreased expression of PDE4DIP mRNA

NCBI chr 1:148,808,434...149,033,016
Ensembl chr 1:148,808,140...149,048,286

G

protein disulfide isomerase family A member 3

affects expression
multiple interactions

Cocaine affects the expression of PDIA3 mRNA
Cocaine affects the reaction [PTN affects the expression of PDIA3 protein modified form]

PMID:20187946 PMID:24096156

NCBI chr15:43,746,438...43,773,278
Ensembl chr15:43,746,394...43,773,279

G

protein disulfide isomerase family A member 4

affects expression

Cocaine affects the expression of PDIA4 mRNA

NCBI chr 7:149,003,051...149,028,505
Ensembl chr 7:149,003,062...149,028,662

G

pyruvate dehydrogenase phosphatase catalytic subunit 1

increases expression

Cocaine results in increased expression of PDP1 mRNA

NCBI chr 8:93,916,923...93,926,068
Ensembl chr 8:93,857,807...93,926,068

G

3-phosphoinositide dependent protein kinase 1

affects expression

Cocaine affects the expression of PDPK1 mRNA

NCBI chr16:2,538,021...2,603,188
Ensembl chr16:2,537,979...2,603,188

G

prodynorphin

increases expression
affects expression
increases response to substance
multiple interactions
affects response to substance
decreases response to substance

Cocaine results in increased expression of PDYN mRNA; Cocaine results in increased expression of PDYN protein
Cocaine deficiency results in increased expression of PDYN mRNA; Cocaine results in increased expression of PDYN mRNA; Cocaine results in increased expression of PDYN protein
Cocaine affects the expression of PDYN mRNA; Cocaine affects the expression of PDYN protein
PDYN gene mutant form results in increased susceptibility to Cocaine
[[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of PDYN protein; Cocaine promotes the reaction [DRD1 protein results in increased expression of PDYN protein]; Cocaine promotes the reaction [DRD3 protein results in decreased expression of PDYN protein]; DRD3 protein inhibits the reaction [Cocaine results in increased expression of PDYN protein]; PDYN protein affects the reaction [Cocaine affects the expression of DRD2 protein]; PDYN protein affects the reaction [Cocaine results in increased activity of OPRM1 protein]; PDYN protein promotes the reaction [Cocaine results in increased abundance of Corticosterone]; RPS6KA3 gene mutant form inhibits the reaction [Cocaine results in increased expression of PDYN protein]
PDYN promoter polymorphism results in increased susceptibility to Cocaine
PDYN gene SNP affects the susceptibility to Cocaine
PDYN promoter polymorphism results in decreased susceptibility to Cocaine

PMID:7905595 PMID:10943692 PMID:10971637 PMID:11427339 PMID:11739600 More...

NCBI chr20:1,978,756...1,994,285
Ensembl chr20:1,978,757...1,994,285

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PDZ domain containing 1

decreases expression

Cocaine results in decreased expression of PDZK1 mRNA

NCBI chr 1:145,670,852...145,707,400
Ensembl chr 1:145,670,852...145,708,148

G

phosphatidylethanolamine binding protein 1

affects expression

Cocaine affects the expression of PEBP1 protein
Cocaine affects the expression of PEBP1 mRNA

PMID:19393250 PMID:20187946

NCBI chr12:118,136,124...118,145,584
Ensembl chr12:118,136,124...118,145,584

G

proenkephalin

decreases expression
increases expression

Cocaine results in decreased expression of PENK mRNA
Cocaine results in increased expression of PENK mRNA
Cocaine deficiency results in increased expression of PENK mRNA; Cocaine results in increased expression of PENK mRNA

PMID:7905595 PMID:8028798 PMID:12523490 PMID:12670717 PMID:15042275 More...

NCBI chr 8:56,440,957...56,446,641
Ensembl chr 8:56,436,674...56,446,671

G

period circadian regulator 1

affects expression
increases expression
multiple interactions

Cocaine affects the expression of PER1 mRNA
Cocaine results in increased expression of PER1 mRNA
Cocaine results in increased expression of PER1 mRNA; Cocaine results in increased expression of PER1 protein
[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PER1 mRNA; Cocaine promotes the reaction [NPAS2 protein binds to PER1 promoter]

PMID:15994025 PMID:18355967 PMID:20187946 PMID:23776671 PMID:27899881

NCBI chr17:8,140,472...8,152,404
Ensembl chr17:8,140,472...8,156,506

G

period circadian regulator 2

affects expression
multiple interactions
increases expression

Cocaine affects the expression of PER2 mRNA
Cocaine promotes the reaction [NPAS2 protein binds to PER2 promoter]
Cocaine results in increased expression of PER2 mRNA; Cocaine results in increased expression of PER2 protein

PMID:15994025 PMID:20056891 PMID:23776671

NCBI chr 2:238,244,044...238,300,065
Ensembl chr 2:238,244,044...238,290,102

G

period circadian regulator 3

increases expression
multiple interactions

Cocaine results in increased expression of PER3 mRNA; Cocaine results in increased expression of PER3 protein
Cocaine promotes the reaction [NPAS2 protein binds to PER3 promoter]

PMID:15994025 PMID:23776671

NCBI chr 1:7,784,291...7,845,177
Ensembl chr 1:7,784,291...7,845,177

G

peroxisomal biogenesis factor 11 beta

affects expression

Cocaine affects the expression of PEX11B mRNA

NCBI chr 1:145,911,348...145,918,717
Ensembl chr 1:145,911,350...145,918,717

G

peroxisomal biogenesis factor 16

increases expression

Cocaine results in increased expression of PEX16 mRNA

NCBI chr11:45,909,663...45,918,822
Ensembl chr11:45,909,663...45,918,812

G

peroxisomal biogenesis factor 2

affects expression

Cocaine affects the expression of PEX2 mRNA

NCBI chr 8:76,980,258...77,001,044
Ensembl chr 8:76,980,258...77,001,044

G

peroxisomal biogenesis factor 5 like

increases expression

Cocaine results in increased expression of PEX5L mRNA

NCBI chr 3:179,794,958...180,036,937
Ensembl chr 3:179,794,958...180,037,053

G

platelet factor 4

increases expression

Cocaine results in increased expression of PF4 protein

NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027

G

phosphofructokinase, liver type

affects expression

Cocaine affects the expression of PFKL mRNA

NCBI chr21:44,300,053...44,327,373
Ensembl chr21:44,300,051...44,327,376

G

profilin 1

increases expression

Cocaine results in increased expression of PFN1 mRNA

NCBI chr17:4,945,652...4,948,530
Ensembl chr17:4,945,652...4,949,061

G

placental growth factor

affects expression

Cocaine affects the expression of PGF mRNA

NCBI chr14:74,941,830...74,955,764
Ensembl chr14:74,941,834...74,955,626

G

progesterone receptor

increases expression
affects expression

Cocaine results in increased expression of PGR protein
Cocaine affects the expression of PGR mRNA

PMID:17109827 PMID:20187946

NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813

G

phosphorylase kinase catalytic subunit gamma 2

affects expression

Cocaine affects the expression of PHKG2 mRNA

NCBI chr16:30,748,425...30,761,176
Ensembl chr16:30,748,293...30,761,176

G

pleckstrin homology like domain family A member 3

affects expression

Cocaine affects the expression of PHLDA3 mRNA

NCBI chr 1:201,464,278...201,469,188
Ensembl chr 1:201,464,278...201,469,237

G

PH domain and leucine rich repeat protein phosphatase 2

affects expression

Cocaine affects the expression of PHLPP2 mRNA

NCBI chr16:71,644,924...71,724,701
Ensembl chr16:71,637,835...71,724,701

G

PILR alpha associated neural protein

affects expression

Cocaine affects the expression of PIANP mRNA

NCBI chr12:6,692,178...6,700,815
Ensembl chr12:6,693,791...6,700,815

G

Pim-1 proto-oncogene, serine/threonine kinase

decreases expression

Cocaine results in decreased expression of PIM1 mRNA

NCBI chr 6:37,170,152...37,175,428
Ensembl chr 6:37,170,152...37,175,428

G

Pim-3 proto-oncogene, serine/threonine kinase

affects expression

Cocaine affects the expression of PIM3 mRNA

NCBI chr22:49,960,772...49,964,072
Ensembl chr22:49,960,768...49,964,072

G

PIN2 (TERF1) interacting telomerase inhibitor 1

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PINX1 mRNA

NCBI chr 8:10,764,961...10,839,875
Ensembl chr 8:10,725,399...10,839,847
Ensembl chr 8:10,725,399...10,839,847

G

pipecolic acid and sarcosine oxidase

decreases expression

Cocaine results in decreased expression of PIPOX mRNA

NCBI chr17:29,043,141...29,057,216
Ensembl chr17:28,950,513...29,057,216

G

phosphatidylinositol transfer protein alpha

affects expression

Cocaine affects the expression of PITPNA mRNA

NCBI chr17:1,517,718...1,562,792
Ensembl chr17:1,517,718...1,562,792

G

paired like homeodomain 3

decreases expression

Cocaine results in decreased expression of PITX3 protein

NCBI chr10:102,230,189...102,241,512
Ensembl chr10:102,230,189...102,241,512

G

praja ring finger ubiquitin ligase 2

decreases expression

Cocaine results in decreased expression of PJA2 mRNA

NCBI chr 5:109,334,722...109,409,974
Ensembl chr 5:109,334,713...109,409,974

G

polycystin 2 like 2, transient receptor potential cation channel

increases expression

Cocaine results in increased expression of PKD2L2 mRNA

NCBI chr 5:137,889,457...137,942,747
Ensembl chr 5:137,887,968...137,942,747

G

pyruvate kinase M1/2

affects expression

Cocaine affects the expression of PKM mRNA

NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819

G

PBX/knotted 1 homeobox 2

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PKNOX2 mRNA

NCBI chr11:125,164,751...125,433,389
Ensembl chr11:125,164,687...125,433,389

G

plakophilin 2

increases expression

Cocaine results in increased expression of PKP2 mRNA

NCBI chr12:32,790,755...32,896,777
Ensembl chr12:32,790,745...32,896,798

G

phospholipase A2 group VI

affects expression

Cocaine affects the expression of PLA2G6 mRNA

NCBI chr22:38,111,495...38,181,830
Ensembl chr22:38,111,495...38,214,778

G

phospholipase A2 receptor 1

increases expression

Cocaine results in increased expression of PLA2R1 mRNA

NCBI chr 2:159,923,933...160,062,615
Ensembl chr 2:159,932,006...160,062,615

G

PLAG1 like zinc finger 1

increases expression

Cocaine results in increased expression of PLAGL1 mRNA

NCBI chr 6:143,940,300...144,064,599
Ensembl chr 6:143,940,300...144,064,599

G

phospholipase C beta 1

increases expression

Cocaine results in increased expression of PLCB1 mRNA

NCBI chr20:8,132,266...8,884,900
Ensembl chr20:8,077,251...8,968,360

G

phospholipase C gamma 1

affects phosphorylation

Cocaine affects the phosphorylation of PLCG1 protein

NCBI chr20:41,137,543...41,177,626
Ensembl chr20:41,136,960...41,196,801

G

phospholipase D2

decreases expression

Cocaine results in decreased expression of PLD2 mRNA

NCBI chr17:4,807,152...4,823,430
Ensembl chr17:4,807,152...4,823,434

G

plectin

affects expression

Cocaine affects the expression of PLEC mRNA

NCBI chr 8:143,915,153...143,976,745
Ensembl chr 8:143,915,153...143,976,734

G

pleckstrin

decreases expression

Cocaine results in decreased expression of PLEK mRNA

NCBI chr 2:68,365,282...68,397,453
Ensembl chr 2:68,365,282...68,397,453

G

pleckstrin homology domain containing A5

affects expression
increases expression

Cocaine affects the expression of PLEKHA5 mRNA
Cocaine results in increased expression of PLEKHA5 mRNA

PMID:17898221 PMID:20187946

NCBI chr12:19,129,733...19,376,400
Ensembl chr12:19,129,669...19,376,400

G

pleckstrin homology domain containing A8

increases expression

Cocaine results in increased expression of PLEKHA8 mRNA

NCBI chr 7:30,028,412...30,130,483
Ensembl chr 7:30,027,404...30,130,483

G

proteolipid protein 1

affects expression
decreases expression

Cocaine affects the expression of PLP1 mRNA
Cocaine results in decreased expression of PLP1 mRNA

PMID:12629581 PMID:15009677 PMID:18357522

NCBI chr X:103,776,506...103,792,619
Ensembl chr X:103,773,718...103,792,619

G

phospholipid phosphatase 1

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PLPP1 mRNA

NCBI chr 5:55,424,854...55,534,964
Ensembl chr 5:55,424,854...55,534,969

G

phospholipid phosphatase 2

decreases expression
affects expression

Cocaine results in decreased expression of PLPP2 mRNA
Cocaine affects the expression of PLPP2 mRNA

PMID:12629581 PMID:20187946

NCBI chr19:281,043...291,403
Ensembl chr19:281,040...291,403

G

phospholipid phosphatase 3

increases expression

Cocaine results in increased expression of PLPP3 mRNA

NCBI chr 1:56,494,761...56,579,563
Ensembl chr 1:56,494,761...56,645,301

G

phospholipid phosphatase related 2

affects expression

Cocaine affects the expression of PLPPR2 mRNA

NCBI chr19:11,355,432...11,365,698
Ensembl chr19:11,355,386...11,365,698

G

plexin B2

affects expression

Cocaine affects the expression of PLXNB2 mRNA

NCBI chr22:50,274,979...50,307,646
Ensembl chr22:50,274,979...50,307,646

G

prostate transmembrane protein, androgen induced 1

increases expression

Cocaine results in increased expression of PMEPA1 mRNA

PMID:15009677 PMID:16710320

NCBI chr20:57,648,396...57,711,472
Ensembl chr20:57,648,392...57,711,536

G

PNMA family member 8B

increases expression

Cocaine results in increased expression of PNMA8B mRNA

NCBI chr19:46,491,191...46,495,867
Ensembl chr19:46,486,906...46,495,879

G

RNA polymerase II, I and III subunit F

affects expression

Cocaine affects the expression of POLR2F mRNA

NCBI chr22:37,953,663...38,041,915
Ensembl chr22:37,952,607...38,041,915

G

proopiomelanocortin

increases secretion
increases expression
increases response to substance
multiple interactions

Cocaine results in increased secretion of POMC protein
Cocaine results in increased expression of POMC protein; Cocaine results in increased expression of POMC protein alternative form
POMC results in increased susceptibility to Cocaine
[CTAP octapeptide binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [POMC protein results in increased susceptibility to Cocaine]; eticlopride inhibits the reaction [Cocaine results in increased expression of POMC protein]

PMID:8301594 PMID:9610951 PMID:11750770 PMID:17001283 PMID:18176854 More...

NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903

G

protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)

affects expression

Cocaine affects the expression of POMGNT1 mRNA

NCBI chr 1:46,188,683...46,220,305
Ensembl chr 1:46,188,683...46,220,305

G

POU class 3 homeobox 1

increases expression

Cocaine results in increased expression of POU3F1 mRNA

NCBI chr 1:38,043,829...38,046,793
Ensembl chr 1:38,043,829...38,046,793

G

POU class 3 homeobox 3

affects expression

Cocaine affects the expression of POU3F3 mRNA

NCBI chr 2:104,854,115...104,858,574
Ensembl chr 2:104,853,287...104,858,574

G

pro-platelet basic protein

increases expression

Cocaine results in increased expression of PPBP protein

NCBI chr 4:73,986,439...73,988,190
Ensembl chr 4:73,986,439...73,988,190

G

PTPRF interacting protein alpha 3

increases expression

Cocaine results in increased expression of PPFIA3 protein

NCBI chr19:49,119,544...49,151,026
Ensembl chr19:49,119,544...49,151,026

G

PPFIA binding protein 1

increases expression

Cocaine results in increased expression of PPFIBP1 mRNA

NCBI chr12:27,524,206...27,695,564
Ensembl chr12:27,523,431...27,695,564

G

peptidylprolyl isomerase B

increases expression

Cocaine results in increased expression of PPIB mRNA

NCBI chr15:64,155,817...64,163,022
Ensembl chr15:64,155,740...64,163,134

G

peptidylprolyl isomerase D

increases expression

Cocaine results in increased expression of PPID mRNA

NCBI chr 4:158,709,127...158,723,396
Ensembl chr 4:158,709,127...158,723,396

G

protein phosphatase 1 catalytic subunit alpha

decreases expression

Cocaine results in decreased expression of PPP1CA mRNA

NCBI chr11:67,398,183...67,401,858
Ensembl chr11:67,398,181...67,421,183

G

protein phosphatase 1 regulatory subunit 12A

affects expression

Cocaine affects the expression of PPP1R12A mRNA

NCBI chr12:79,773,563...79,935,460
Ensembl chr12:79,773,563...79,935,460

G

protein phosphatase 1 regulatory subunit 15A

increases expression

Cocaine results in increased expression of PPP1R15A mRNA

NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,212...48,876,059

G

protein phosphatase 1 regulatory inhibitor subunit 1B

multiple interactions
increases phosphorylation
affects phosphorylation
increases response to substance
affects response to substance
increases expression

[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]; CNR1 gene mutant form inhibits the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]; Cocaine promotes the reaction [PPP1R1B protein results in increased abundance of Adrenocorticotropic Hormone]; Cocaine promotes the reaction [PPP1R1B protein results in increased abundance of Corticosterone]; N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of PPP1R1B protein]; PPP1R1B gene mutant form inhibits the reaction [Cocaine results in increased expression of FOSB protein]; resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]
Cocaine affects the phosphorylation of PPP1R1B protein
6-methyl-2-(phenylethynyl)pyridine affects the reaction [Cocaine affects the phosphorylation of PPP1R1B protein]; Cocaine inhibits the reaction [SK&F 81297 results in increased phosphorylation of PPP1R1B protein]; roscovitine affects the reaction [Cocaine affects the phosphorylation of PPP1R1B protein]
PPP1R1B gene mutant form results in increased susceptibility to Cocaine; PPP1R1B mutant form results in increased susceptibility to Cocaine
PPP1R1B affects the susceptibility to Cocaine

PMID:10103106 PMID:10516482 PMID:11268215 PMID:15287884 PMID:15665076 More...

NCBI chr17:39,626,707...39,636,624
Ensembl chr17:39,626,740...39,636,626

G

protein phosphatase 1 regulatory subunit 7

increases expression
multiple interactions

Cocaine results in increased expression of PPP1R7 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PPP1R7 mRNA]

NCBI chr 2:241,149,573...241,183,652
Ensembl chr 2:241,149,576...241,183,652

G

protein phosphatase 2 catalytic subunit alpha

decreases expression

Cocaine results in decreased expression of PPP2CA mRNA

NCBI chr 5:134,194,332...134,226,073
Ensembl chr 5:134,194,035...134,226,073

G

protein phosphatase 2 catalytic subunit beta

decreases expression

Cocaine results in decreased expression of PPP2CB mRNA

NCBI chr 8:30,785,616...30,812,818
Ensembl chr 8:30,774,457...30,814,314

G

protein phosphatase 2 regulatory subunit Bbeta

affects expression

Cocaine affects the expression of PPP2R2B mRNA

NCBI chr 5:146,580,742...147,081,520
Ensembl chr 5:146,580,742...147,084,784

G

protein phosphatase 2 regulatory subunit Bgamma

decreases expression

Cocaine results in decreased expression of PPP2R2C mRNA

NCBI chr 4:6,320,581...6,563,799
Ensembl chr 4:6,320,578...6,563,600

G

protein phosphatase 3 catalytic subunit alpha

affects expression

Cocaine affects the expression of PPP3CA mRNA

NCBI chr 4:101,023,418...101,347,526
Ensembl chr 4:101,023,409...101,348,278

G

protein phosphatase 3 regulatory subunit B, beta

decreases expression

Cocaine results in decreased expression of PPP3R2 mRNA

NCBI chr 9:101,591,604...101,594,969
Ensembl chr 9:101,591,604...101,595,021

G

protein phosphatase 5 catalytic subunit

increases expression

Cocaine results in increased expression of PPP5C protein

NCBI chr19:46,347,087...46,390,975
Ensembl chr19:46,347,087...46,392,981

G

protein phosphatase 6 catalytic subunit

affects expression

Cocaine affects the expression of PPP6C mRNA

NCBI chr 9:125,146,573...125,189,803
Ensembl chr 9:125,146,573...125,189,939

G

polyglutamine binding protein 1

affects expression

Cocaine affects the expression of PQBP1 mRNA

NCBI chr X:48,897,930...48,903,143
Ensembl chr X:48,890,197...48,903,402

G

PR/SET domain 2

increases expression

Cocaine results in increased expression of PRDM2 mRNA

NCBI chr 1:13,700,188...13,825,079
Ensembl chr 1:13,700,188...13,825,079

G

peroxiredoxin 2

affects expression
decreases expression

Cocaine affects the expression of PRDX2 protein
Cocaine results in decreased expression of PRDX2 protein

PMID:17075605 PMID:19393250

NCBI chr19:12,796,823...12,801,800
Ensembl chr19:12,796,820...12,801,800

G

peroxiredoxin 5

affects expression

Cocaine affects the expression of PRDX5 protein

NCBI chr11:64,318,121...64,321,811
Ensembl chr11:64,318,121...64,321,811

G

prolyl endopeptidase like

increases expression

Cocaine results in increased expression of PREPL mRNA

NCBI chr 2:44,317,607...44,361,862
Ensembl chr 2:44,316,281...44,361,862

G

prickle planar cell polarity protein 2

increases expression

Cocaine results in increased expression of PRICKLE2 mRNA

NCBI chr 3:64,092,236...64,268,173
Ensembl chr 3:64,092,236...64,445,476

G

protein kinase cAMP-activated catalytic subunit alpha

multiple interactions
affects expression
affects activity

[Cocaine affects the activity of PRKACA protein] which affects the phosphorylation of DPYSL2 protein; [Cocaine affects the activity of PRKACA protein] which affects the phosphorylation of GNAO1 protein alternative form; Cocaine affects the activity of and affects the expression of PRKACA protein
Cocaine affects the expression of PRKACA protein

PMID:12595601 PMID:15659224 PMID:19457111

NCBI chr19:14,091,688...14,117,762
Ensembl chr19:14,091,688...14,118,084

G

protein kinase C alpha

increases expression
decreases expression
multiple interactions

Cocaine results in increased expression of PRKCA protein
Cocaine results in decreased expression of PRKCA mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of PRKCA mRNA]

PMID:12808488 PMID:18355967

NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743

G

protein kinase C beta

decreases expression
increases expression

Cocaine results in decreased expression of PRKCB mRNA
Cocaine results in increased expression of PRKCB mRNA

PMID:12629581 PMID:17898221

NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611

G

protein kinase C delta

multiple interactions
increases cleavage

Cocaine results in increased expression of and results in increased cleavage of PRKCD protein; GPX1 affects the reaction [Cocaine results in increased cleavage of PRKCD protein]; PRKCD protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; PRKCD protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; PRKCD protein affects the reaction [Cocaine results in increased activity of and affects the localization of NFE2L2 protein]; PRKCD protein affects the reaction [Cocaine results in increased activity of GPT protein]; PRKCD protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; PRKCD protein affects the reaction [Cocaine results in increased expression of GCLC mRNA]; PRKCD protein affects the reaction [Cocaine results in increased expression of GCLM mRNA]

PMID:30027653 PMID:30393195

NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717

G

protein kinase C epsilon

affects expression
decreases phosphorylation
decreases expression

Cocaine affects the expression of PRKCE mRNA
Cocaine results in decreased phosphorylation of PRKCE protein
Cocaine results in decreased expression of PRKCE protein

PMID:15677681 PMID:20187946

NCBI chr 2:45,651,279...46,187,990
Ensembl chr 2:45,651,345...46,187,990

G

protein kinase C gamma

increases expression

Cocaine results in increased expression of PRKCG mRNA

NCBI chr19:53,881,094...53,907,652
Ensembl chr19:53,879,190...53,907,652

G

protein kinase C zeta

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PRKCZ mRNA

NCBI chr 1:2,048,504...2,185,395
Ensembl chr 1:2,050,411...2,185,395

G

prolactin

affects expression
decreases expression
increases expression
decreases secretion
affects secretion
multiple interactions

Cocaine affects the expression of PRL protein
cocaine decreases expression of Prl protein in blood plasma
Cocaine results in decreased expression of PRL protein
Cocaine results in increased expression of PRL protein
Cocaine results in decreased secretion of PRL protein
Cocaine affects the secretion of PRL protein
Cocaine affects the reaction [Fenfluramine results in increased expression of PRL protein]; Cocaine inhibits the reaction [1-(3-chlorophenyl)piperazine results in increased expression of PRL protein]

CTD
RGD

PMID:2584360 PMID:10349036 PMID:12892653 PMID:12893845 PMID:14512708 More...

NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826

G

protamine 1

multiple interactions

HDAC5 affects the reaction [Cocaine affects the expression of PRM1 mRNA]

NCBI chr16:11,280,841...11,281,330
Ensembl chr16:11,280,841...11,281,330

G

protein arginine methyltransferase 1

decreases expression

Cocaine results in decreased expression of PRMT1 mRNA

NCBI chr19:49,676,153...49,688,447
Ensembl chr19:49,675,786...49,689,029

G

protein arginine methyltransferase 2

decreases expression

Cocaine results in decreased expression of PRMT2 mRNA

NCBI chr21:46,635,674...46,665,124
Ensembl chr21:46,635,595...46,665,124

G

protein arginine methyltransferase 5

decreases expression

Cocaine results in decreased expression of PRMT5 mRNA

NCBI chr14:22,920,529...22,929,376
Ensembl chr14:22,920,525...22,929,408

G

protein arginine methyltransferase 6

decreases expression
multiple interactions
affects response to substance

Cocaine results in decreased expression of PRMT6 mRNA; Cocaine results in decreased expression of PRMT6 protein
PRMT6 protein inhibits the reaction [Cocaine results in increased expression of SRCIN1 protein]
PRMT6 protein affects the susceptibility to Cocaine

NCBI chr 1:107,056,674...107,059,294
Ensembl chr 1:107,056,674...107,067,636

G

protein arginine methyltransferase 8

decreases expression

Cocaine results in decreased expression of PRMT8 mRNA

NCBI chr12:3,381,349...3,593,973
Ensembl chr12:3,381,349...3,593,973

G

protein arginine methyltransferase 9

decreases expression

Cocaine results in decreased expression of PRMT9 mRNA

NCBI chr 4:147,637,785...147,684,163
Ensembl chr 4:147,637,785...147,684,163

G

proline dehydrogenase 2

increases expression

Cocaine results in increased expression of PRODH2 mRNA

NCBI chr19:35,799,988...35,812,845
Ensembl chr19:35,799,988...35,813,299

G

prominin 2

decreases expression

Cocaine results in decreased expression of PROM2 mRNA

NCBI chr 2:95,274,449...95,291,302
Ensembl chr 2:95,274,449...95,291,308

G

pre-mRNA processing factor 18

increases expression
multiple interactions

Cocaine results in increased expression of PRPF18 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PRPF18 mRNA]

NCBI chr10:13,586,965...13,655,929
Ensembl chr10:13,586,939...13,668,445

G

pre-mRNA processing factor 19

affects expression

Cocaine affects the expression of PRPF19 mRNA

NCBI chr11:60,890,547...60,906,585
Ensembl chr11:60,890,547...60,906,585

G

proline rich transmembrane protein 1

affects expression

Cocaine affects the expression of PRRT1 mRNA

NCBI chr 6:32,148,363...32,153,083
Ensembl chr 6:32,148,359...32,153,083

G

proteinase 3

multiple interactions

Cocaine affects the reaction [Antibodies, Antineutrophil Cytoplasmic binds to PRTN3 protein]

NCBI chr19:840,999...848,175
Ensembl chr19:840,999...848,175

G

proteasome 20S subunit beta 7

decreases expression

Cocaine results in decreased expression of PSMB7 protein

NCBI chr 9:124,353,465...124,415,442
Ensembl chr 9:124,353,465...124,415,444

G

proteasome activator subunit 4

increases expression

Cocaine results in increased expression of PSME4 mRNA

NCBI chr 2:53,864,069...53,970,993
Ensembl chr 2:53,864,069...53,970,993

G

phosphatidylserine synthase 1

affects expression

Cocaine affects the expression of PTDSS1 mRNA

NCBI chr 8:96,261,902...96,336,995
Ensembl chr 8:96,261,902...96,336,995

G

phosphatase and tensin homolog

affects expression

Cocaine affects the expression of PTEN mRNA

NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930

G

protein tyrosine kinase 2

decreases expression
decreases phosphorylation

Cocaine results in decreased expression of PTK2 mRNA
Cocaine results in decreased phosphorylation of PTK2 protein

PMID:12629581 PMID:27506785

NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216

G

protein tyrosine kinase 2 beta

increases expression

Cocaine results in increased expression of PTK2B protein

NCBI chr 8:27,310,506...27,459,391
Ensembl chr 8:27,311,482...27,459,391

G

pleiotrophin

decreases expression
multiple interactions

Cocaine results in decreased expression of PTN mRNA
Cocaine affects the reaction [PTN affects the expression of PDIA3 protein modified form]

PMID:12629581 PMID:24096156

NCBI chr 7:137,227,341...137,343,733
Ensembl chr 7:137,227,341...137,343,774

G

PTOV1 extended AT-hook containing adaptor protein

affects expression

Cocaine affects the expression of PTOV1 mRNA

NCBI chr19:49,850,705...49,860,742
Ensembl chr19:49,850,735...49,860,744

G

protein tyrosine phosphatase non-receptor type 3

affects expression

Cocaine affects the expression of PTPN3 mRNA

NCBI chr 9:109,375,694...109,538,420
Ensembl chr 9:109,375,466...109,498,313

G

protein tyrosine phosphatase receptor type A

decreases expression

Cocaine results in decreased expression of PTPRA mRNA

NCBI chr20:2,864,184...3,038,669
Ensembl chr20:2,873,420...3,039,076

G

protein tyrosine phosphatase receptor type B

decreases expression

Cocaine results in decreased expression of PTPRB mRNA

NCBI chr12:70,515,870...70,637,429
Ensembl chr12:70,515,870...70,637,440

G

protein tyrosine phosphatase receptor type V, pseudogene

increases expression
multiple interactions

Cocaine results in increased expression of PTPRV mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PTPRV mRNA]

NCBI chr 1:202,168,051...202,189,449
Ensembl chr 1:202,168,051...202,189,455
Ensembl chr 1:202,168,051...202,189,455

G

purine rich element binding protein B

affects expression

Cocaine affects the expression of PURB mRNA

NCBI chr 7:44,876,299...44,885,530
Ensembl chr 7:44,876,299...44,885,530

G

parvalbumin

decreases expression
affects expression

Cocaine results in decreased expression of PVALB protein
Cocaine affects the expression of PVALB protein

PMID:15219666 PMID:17075605

NCBI chr22:36,800,703...36,819,499
Ensembl chr22:36,800,684...36,819,479

G

quinolinate phosphoribosyltransferase

affects expression

Cocaine affects the expression of QPRT mRNA

NCBI chr16:29,679,008...29,698,699
Ensembl chr16:29,663,279...29,698,699

G

queuine tRNA-ribosyltransferase catalytic subunit 1

affects expression

Cocaine affects the expression of QTRT1 mRNA

NCBI chr19:10,701,439...10,713,365
Ensembl chr19:10,701,430...10,713,437

G

R3H domain containing 2

affects expression

Cocaine affects the expression of R3HDM2 mRNA

NCBI chr12:57,253,764...57,431,141
Ensembl chr12:57,253,762...57,431,043

G

RAB12, member RAS oncogene family

decreases expression

Cocaine results in decreased expression of RAB12 mRNA

NCBI chr18:8,609,437...8,639,383
Ensembl chr18:8,609,437...8,639,383

G

RAB14, member RAS oncogene family

affects expression

Cocaine affects the expression of RAB14 mRNA

NCBI chr 9:121,178,133...121,201,869
Ensembl chr 9:121,178,133...121,223,014

G

RAB15, member RAS oncogene family

affects expression

Cocaine affects the expression of RAB15 mRNA

NCBI chr14:64,945,816...64,972,336
Ensembl chr14:64,945,814...64,973,226

G

RAB31, member RAS oncogene family

affects expression

Cocaine affects the expression of RAB31 mRNA

NCBI chr18:9,708,301...9,862,551
Ensembl chr18:9,708,275...9,862,551

G

RAB3A, member RAS oncogene family

increases expression

Cocaine results in increased expression of RAB3A mRNA

NCBI chr19:18,196,784...18,204,042
Ensembl chr19:18,196,784...18,204,042

G

RAB3C, member RAS oncogene family

increases expression

Cocaine results in increased expression of RAB3C mRNA

NCBI chr 5:58,582,152...58,859,394
Ensembl chr 5:58,582,221...58,859,394

G

Rac family small GTPase 1

affects expression
increases expression

Cocaine affects the expression of RAC1 mRNA
Cocaine results in increased expression of RAC1 protein

PMID:18952886 PMID:20187946

NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

[[Cocaine results in increased expression of MIR212 mRNA] which results in increased activity of RAF1 protein] which results in increased expression of CRTC1 protein; [Cocaine results in increased expression of MIR212 mRNA] which results in increased activity of RAF1 protein

NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201

G

retinoic acid induced 14

increases expression

Cocaine results in increased expression of RAI14 mRNA

NCBI chr 5:34,656,328...34,832,612
Ensembl chr 5:34,656,328...34,832,612

G

Ral GEF with PH domain and SH3 binding motif 2

increases expression

Cocaine results in increased expression of RALGPS2 mRNA

NCBI chr 1:178,725,244...178,921,840
Ensembl chr 1:178,725,165...178,921,842

G

Rap guanine nucleotide exchange factor 4

affects expression

Cocaine affects the expression of RAPGEF4 mRNA

NCBI chr 2:172,735,318...173,052,893
Ensembl chr 2:172,735,274...173,052,893

G

Rap guanine nucleotide exchange factor 6

multiple interactions

HDAC5 affects the reaction [Cocaine affects the expression of RAPGEF6 mRNA]

NCBI chr 5:131,423,921...131,635,229
Ensembl chr 5:131,423,921...131,635,231

G

Ras protein specific guanine nucleotide releasing factor 1

affects expression
increases expression

Cocaine affects the expression of RASGRF1 mRNA
Cocaine results in increased expression of RASGRF1 protein

PMID:17931779 PMID:20187946

NCBI chr15:78,959,906...79,090,780
Ensembl chr15:78,959,906...79,090,780

G

RAS like family 11 member A

increases expression

Cocaine results in increased expression of RASL11A mRNA

NCBI chr13:27,270,830...27,275,192
Ensembl chr13:27,270,830...27,275,192

G

RNA binding motif protein 12

affects expression

Cocaine affects the expression of RBM12 mRNA

NCBI chr20:35,648,925...35,664,900
Ensembl chr20:35,648,925...35,664,956

G

RNA binding motif protein 14

decreases expression
affects expression

Cocaine results in decreased expression of RBM14 mRNA
Cocaine affects the expression of RBM14 mRNA

PMID:17898221 PMID:20187946

NCBI chr11:66,616,630...66,629,934
Ensembl chr11:66,616,626...66,629,934

G

RNA binding motif protein 26

affects expression

Cocaine affects the expression of RBM26 mRNA

NCBI chr13:79,311,827...79,406,255
Ensembl chr13:79,311,824...79,406,477

G

RNA binding motif protein 42

affects expression

Cocaine affects the expression of RBM42 mRNA

NCBI chr19:35,629,036...35,637,685
Ensembl chr19:35,629,030...35,637,686

G

RCSD domain containing 1

increases expression

Cocaine results in increased expression of RCSD1 mRNA

NCBI chr 1:167,630,232...167,708,696
Ensembl chr 1:167,630,093...167,708,696

G

retinol dehydrogenase 10

affects expression

Cocaine affects the expression of RDH10 mRNA

NCBI chr 8:73,294,602...73,325,281
Ensembl chr 8:73,294,602...73,325,281

G

reversion inducing cysteine rich protein with kazal motifs

increases expression

Cocaine results in increased expression of RECK protein

NCBI chr 9:36,036,913...36,124,455
Ensembl chr 9:36,036,913...36,124,455

G

RecQ like helicase

affects expression

Cocaine affects the expression of RECQL mRNA

NCBI chr12:21,468,910...21,501,635
Ensembl chr12:21,468,910...21,501,669

G

regenerating family member 3 gamma

decreases expression

Cocaine results in decreased expression of REG3G mRNA

NCBI chr 2:79,025,702...79,028,501
Ensembl chr 2:79,025,686...79,028,505

G

REL proto-oncogene, NF-kB subunit

affects expression
decreases activity

Cocaine affects the expression of REL protein
Cocaine results in decreased activity of REL protein

PMID:16179556 PMID:20477932

NCBI chr 2:60,881,574...60,931,612
Ensembl chr 2:60,881,491...60,931,612

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases activity
increases localization

acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]; AG 1879 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]; Cocaine promotes the reaction [RELA protein binds to CCL2 promoter]; Cocaine results in increased activity of and affects the localization of RELA protein; Cocaine results in increased phosphorylation of and results in increased activity of RELA protein; GPX1 protein inhibits the reaction [Cocaine affects the localization of RELA protein]; GPX1 protein inhibits the reaction [Cocaine results in increased activity of and affects the localization of RELA protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]; RELA mutant form inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]
Cocaine results in increased activity of RELA protein
SCH 23390 inhibits the reaction [Cocaine results in increased activity of RELA protein]
Cocaine results in increased localization of RELA protein

PMID:19183502 PMID:20354174 PMID:31059705

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

RELT like 2

affects expression

Cocaine affects the expression of RELL2 mRNA

NCBI chr 5:141,636,997...141,641,064
Ensembl chr 5:141,636,950...141,641,064

G

reelin

increases expression

Cocaine results in increased expression of RELN mRNA

NCBI chr 7:103,471,789...103,989,658
Ensembl chr 7:103,471,381...103,989,658

G

reticulophagy regulator family member 2

affects expression

Cocaine affects the expression of RETREG2 mRNA

NCBI chr 2:219,178,275...219,185,475
Ensembl chr 2:219,176,225...219,185,475

G

regulator of G protein signaling 2

affects expression
increases expression

Cocaine affects the expression of RGS2 mRNA
Cocaine results in increased expression of RGS2 mRNA

PMID:10098858 PMID:20187946

NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275

G

regulator of G protein signaling 20

multiple interactions

HDAC5 affects the reaction [Cocaine affects the expression of RGS20 mRNA]

NCBI chr 8:53,851,795...53,959,303
Ensembl chr 8:53,851,795...53,959,303

G

regulator of G protein signaling 4

decreases expression
affects expression
increases expression

Cocaine results in decreased expression of RGS4 mRNA
Cocaine affects the expression of RGS4 mRNA
Cocaine results in increased expression of RGS4 mRNA

PMID:12270694 PMID:17632279 PMID:20187946

NCBI chr 1:163,068,871...163,076,802
Ensembl chr 1:163,068,775...163,076,802

G

regulator of G protein signaling 9

affects expression

Cocaine affects the expression of RGS9 mRNA

NCBI chr17:65,137,370...65,227,703
Ensembl chr17:65,100,812...65,227,703

G

ras homolog family member A

multiple interactions

[Cocaine co-treated with Cocaine deficiency] inhibits the reaction [SMURF1 protein binds to RHOA protein]; [Cocaine co-treated with Cocaine deficiency] results in decreased ubiquitination of RHOA protein; [Cocaine co-treated with Cocaine deficiency] results in increased expression of and results in decreased activity of RHOA protein

NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998

G

ras homolog family member G

affects expression

Cocaine affects the expression of RHOG mRNA

NCBI chr11:3,826,978...3,840,959
Ensembl chr11:3,826,978...3,840,959

G

ras homolog family member T2

affects expression

Cocaine affects the expression of RHOT2 mRNA

NCBI chr16:668,083...674,174
Ensembl chr16:668,100...674,174

G

ring finger protein 1

affects expression

Cocaine affects the expression of RING1 mRNA

NCBI chr 6:33,208,500...33,212,716
Ensembl chr 6:33,208,500...33,212,722

G

receptor interacting serine/threonine kinase 1

decreases expression

Cocaine results in decreased expression of RIPK1 mRNA

NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,824...3,115,187

G

Rho family GTPase 2

affects expression

Cocaine affects the expression of RND2 mRNA

NCBI chr17:43,025,231...43,032,041
Ensembl chr17:43,025,231...43,032,041

G

Rho family GTPase 3

increases expression

Cocaine results in increased expression of RND3 mRNA

NCBI chr 2:150,468,193...150,487,695
Ensembl chr 2:150,468,195...150,539,011

G

ring finger protein 14

increases expression

Cocaine results in increased expression of RNF14 protein

NCBI chr 5:141,949,337...141,990,292
Ensembl chr 5:141,958,328...141,990,292

G

ring finger protein 32

affects expression

Cocaine affects the expression of RNF32 mRNA

NCBI chr 7:156,640,204...156,677,130
Ensembl chr 7:156,640,281...156,677,130

G

Ro60, Y RNA binding protein

decreases expression

Cocaine results in decreased expression of RO60 mRNA

NCBI chr 1:193,059,612...193,091,777
Ensembl chr 1:193,059,454...193,091,777

G

Rho associated coiled-coil containing protein kinase 2

affects expression

Cocaine affects the expression of ROCK2 mRNA

NCBI chr 2:11,179,759...11,345,437
Ensembl chr 2:11,179,759...11,348,330

G

RAR related orphan receptor B

increases expression

Cocaine results in increased expression of RORB mRNA

NCBI chr 9:74,497,335...74,693,177
Ensembl chr 9:74,497,335...74,693,177

G

ribosomal protein L10

affects expression

Cocaine affects the expression of RPL10 mRNA

NCBI chr X:154,398,065...154,402,339
Ensembl chr X:154,389,955...154,409,168

G

ribosomal protein L19

affects expression

Cocaine affects the expression of RPL19 mRNA

NCBI chr17:39,200,283...39,204,732
Ensembl chr17:39,200,283...39,204,840

G

ribosomal protein L32

affects expression

Cocaine affects the expression of RPL32 mRNA

NCBI chr 3:12,834,485...12,841,582
Ensembl chr 3:12,834,485...12,841,582

G

ribosomal protein L36

affects expression

Cocaine affects the expression of RPL36 mRNA

NCBI chr19:5,690,295...5,691,875
Ensembl chr19:5,674,947...5,691,875

G

ribosomal protein L6

affects expression

Cocaine affects the expression of RPL6 mRNA

NCBI chr12:112,405,181...112,418,835
Ensembl chr12:112,405,189...112,418,838

G

ribosomal protein L9

decreases expression

Cocaine results in decreased expression of RPL9 mRNA

NCBI chr 4:39,454,124...39,458,922
Ensembl chr 4:39,452,587...39,458,931

G

ribosomal protein S10

affects expression
decreases expression

Cocaine affects the expression of RPS10 mRNA
Cocaine results in decreased expression of RPS10 mRNA

PMID:15009677 PMID:20187946

NCBI chr 6:34,417,454...34,426,069
Ensembl chr 6:34,417,454...34,426,069

G

ribosomal protein S16

affects expression

Cocaine affects the expression of RPS16 mRNA

NCBI chr19:39,433,137...39,435,949
Ensembl chr19:39,433,137...39,435,949

G

ribosomal protein S6 kinase A1

multiple interactions

Cocaine promotes the reaction [RPS6KA1 protein binds to CREB1 protein]; Cocaine results in increased phosphorylation of and results in increased activity of RPS6KA1 protein

NCBI chr 1:26,529,761...26,575,025
Ensembl chr 1:26,529,761...26,575,030

G

ribosomal protein S6 kinase A3

multiple interactions

RPS6KA3 affects the reaction [Cocaine results in increased phosphorylation of FOS protein]; RPS6KA3 gene mutant form inhibits the reaction [Cocaine results in increased expression of PDYN protein]; RPS6KA3 gene mutant form inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]

NCBI chr X:20,149,911...20,267,097
Ensembl chr X:20,149,911...20,267,519

G

ribosomal protein S6 kinase A5

increases expression
affects response to substance
increases activity
multiple interactions

Cocaine results in increased expression of RPS6KA5 mRNA; Cocaine results in increased expression of RPS6KA5 protein
RPS6KA5 affects the susceptibility to Cocaine
Cocaine results in increased activity of RPS6KA5 protein
Cocaine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein]

PMID:16339038 PMID:17898221 PMID:25100957

NCBI chr14:90,847,861...91,060,641
Ensembl chr14:90,847,861...91,060,641

G

ribosomal protein S9

decreases expression

Cocaine results in decreased expression of RPS9 mRNA

NCBI chr19:54,200,858...54,207,647
Ensembl chr19:54,200,809...54,249,003

G

ribosomal protein SA

decreases expression

Cocaine results in decreased expression of RPSA mRNA

NCBI chr 3:39,406,720...39,412,542
Ensembl chr 3:39,406,716...39,426,255

G

round spermatid basic protein 1 like

increases expression

Cocaine results in increased expression of RSBN1L mRNA

NCBI chr 7:77,696,459...77,783,022
Ensembl chr 7:77,696,459...77,783,022

G

radial spoke head component 1

increases expression

Cocaine results in increased expression of RSPH1 mRNA

NCBI chr21:42,472,486...42,496,224
Ensembl chr21:42,472,486...42,496,246

G

rhotekin

affects expression

Cocaine affects the expression of RTKN mRNA

NCBI chr 2:74,425,835...74,441,937
Ensembl chr 2:74,425,835...74,442,422

G

reticulon 4 interacting protein 1

increases expression

Cocaine results in increased expression of RTN4IP1 protein

NCBI chr 6:106,570,771...106,630,491
Ensembl chr 6:106,570,771...106,629,498

G

RUNX family transcription factor 1

affects expression

Cocaine affects the expression of RUNX1 mRNA

NCBI chr21:34,787,801...35,049,302
Ensembl chr21:34,787,801...36,004,667

G

RUNX1 partner transcriptional co-repressor 1

increases expression

Cocaine results in increased expression of RUNX1T1 mRNA

NCBI chr 8:91,954,967...92,103,385
Ensembl chr 8:91,954,972...92,103,385

G

RUNX family transcription factor 2

multiple interactions

[Cocaine co-treated with Cocaine deficiency] promotes the reaction [RUNX2 protein binds to DNM1L promoter]; [Cocaine co-treated with Cocaine deficiency] promotes the reaction [RUNX2 protein binds to EGR3 promoter]; [Cocaine co-treated with Cocaine deficiency] promotes the reaction [RUNX2 protein binds to SMARCA4 promoter]; [Cocaine co-treated with Cocaine deficiency] results in increased expression of and results in increased activity of RUNX2 protein

NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349

G

RING1 and YY1 binding protein

increases expression

Cocaine results in increased expression of RYBP mRNA

NCBI chr 3:72,374,597...72,446,623
Ensembl chr 3:72,371,825...72,446,621

G

ryanodine receptor 2

affects expression
increases expression

Cocaine affects the expression of RYR2 mRNA
Cocaine results in increased expression of RYR2 mRNA

PMID:20187946 PMID:21113126

NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988

G

ryanodine receptor 3

affects expression

Cocaine affects the expression of RYR3 mRNA

NCBI chr15:33,310,967...33,866,102
Ensembl chr15:33,310,962...33,866,121

G

S100 calcium binding protein B

multiple interactions
affects expression

ipsapirone inhibits the reaction [Cocaine affects the expression of S100B protein]

NCBI chr21:46,598,604...46,605,082
Ensembl chr21:46,598,604...46,605,208

G

sphingosine-1-phosphate receptor 2

decreases expression

Cocaine results in decreased expression of S1PR2 mRNA

NCBI chr19:10,221,433...10,231,331
Ensembl chr19:10,221,433...10,231,331

G

S-antigen visual arrestin

affects expression

Cocaine affects the expression of SAG mRNA

NCBI chr 2:233,307,816...233,347,055
Ensembl chr 2:233,307,816...233,347,055

G

secretion associated Ras related GTPase 1A

affects expression

Cocaine affects the expression of SAR1A mRNA

NCBI chr10:70,147,289...70,170,514
Ensembl chr10:70,147,289...70,170,523

G

spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP

affects expression

Cocaine affects the expression of SART1 mRNA

NCBI chr11:65,961,734...65,980,137
Ensembl chr11:65,961,728...65,980,137

G

SATB homeobox 1

decreases expression
multiple interactions

Cocaine results in decreased expression of SATB1 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of SATB1 mRNA]

NCBI chr 3:18,345,377...18,445,592
Ensembl chr 3:18,345,377...18,445,621

G

SATB homeobox 2

multiple interactions
decreases expression

[Cocaine co-treated with FOS protein mutant form] results in increased expression of SATB2 mRNA
Cocaine results in decreased expression of SATB2 mRNA

NCBI chr 2:199,269,500...199,471,266
Ensembl chr 2:199,269,505...199,471,266

G

strawberry notch homolog 1

increases expression

Cocaine results in increased expression of SBNO1 mRNA

NCBI chr12:123,289,109...123,364,847
Ensembl chr12:123,289,109...123,364,847

G

suprabasin

increases expression
multiple interactions

Cocaine results in increased expression of SBSN mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of SBSN mRNA]

NCBI chr19:35,523,367...35,528,311
Ensembl chr19:35,523,367...35,528,351

G

scavenger receptor class B member 1

increases expression

Cocaine results in increased expression of SCARB1 mRNA

NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668

G

secretogranin II

increases expression

Cocaine results in increased expression of SCG2 mRNA; Cocaine results in increased expression of SCG2 protein

PMID:19918966 PMID:27899881

NCBI chr 2:223,596,940...223,602,361
Ensembl chr 2:223,596,940...223,602,361

G

sodium voltage-gated channel alpha subunit 10

affects expression

Cocaine affects the expression of SCN10A mRNA

NCBI chr 3:38,696,807...38,816,217
Ensembl chr 3:38,696,802...38,816,286

G

sodium voltage-gated channel beta subunit 2

increases expression

Cocaine results in increased expression of SCN2B mRNA

NCBI chr11:118,162,806...118,176,639
Ensembl chr11:118,162,806...118,176,639

G

SCY1 like pseudokinase 1

affects expression

Cocaine affects the expression of SCYL1 mRNA

NCBI chr11:65,525,083...65,538,704
Ensembl chr11:65,525,077...65,538,704

G

SDA1 domain containing 1

increases expression

Cocaine results in increased expression of SDAD1 mRNA

NCBI chr 4:75,949,915...75,990,945
Ensembl chr 4:75,940,950...75,990,962

G

selenoprotein S

affects expression

Cocaine affects the expression of SELENOS mRNA

NCBI chr15:101,270,809...101,277,485
Ensembl chr15:101,270,817...101,277,500

G

selectin P

affects localization

Cocaine affects the localization of SELP protein

PMID:7689042 PMID:10814631

NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193

G

semaphorin 3A

decreases expression

Cocaine results in decreased expression of SEMA3A mRNA

NCBI chr 7:83,955,777...84,492,725
Ensembl chr 7:83,955,777...84,492,724

G

semaphorin 3B

increases expression

Cocaine results in increased expression of SEMA3B mRNA

PMID:15691709 PMID:17205118

NCBI chr 3:50,267,652...50,277,546
Ensembl chr 3:50,267,558...50,277,546

G

semaphorin 3C

affects expression

Cocaine affects the expression of SEMA3C mRNA

NCBI chr 7:80,742,538...80,922,389
Ensembl chr 7:80,742,538...80,922,359

G

semaphorin 3E

affects expression

Cocaine affects the expression of SEMA3E mRNA

NCBI chr 7:83,363,238...83,649,139
Ensembl chr 7:83,363,238...83,649,139

G

semaphorin 3F

affects expression

Cocaine affects the expression of SEMA3F mRNA

NCBI chr 3:50,155,058...50,189,075
Ensembl chr 3:50,155,045...50,189,075

G

semaphorin 4A

affects expression

Cocaine affects the expression of SEMA4A mRNA

NCBI chr 1:156,147,373...156,177,744
Ensembl chr 1:156,147,366...156,177,752

G

semaphorin 4B

increases expression

Cocaine results in increased expression of SEMA4B mRNA

NCBI chr15:90,184,920...90,229,661
Ensembl chr15:90,160,604...90,229,679

G

semaphorin 4C

increases expression

Cocaine results in increased expression of SEMA4C mRNA

NCBI chr 2:96,859,718...96,870,830
Ensembl chr 2:96,859,718...96,870,757

G

semaphorin 4D

affects expression

Cocaine affects the expression of SEMA4D mRNA

NCBI chr 9:89,360,787...89,498,113
Ensembl chr 9:89,360,787...89,498,130

G

ssemaphorin 4F

increases expression

Cocaine results in increased expression of SEMA4F mRNA

NCBI chr 2:74,654,247...74,709,713
Ensembl chr 2:74,654,228...74,683,853

G

semaphorin 4G

affects expression

Cocaine affects the expression of SEMA4G mRNA

NCBI chr10:100,969,504...100,985,616
Ensembl chr10:100,969,504...100,985,871

G

semaphorin 5A

affects expression

Cocaine affects the expression of SEMA5A mRNA

NCBI chr 5:9,035,033...9,546,075
Ensembl chr 5:9,035,033...9,546,075

G

semaphorin 5B

affects expression

Cocaine affects the expression of SEMA5B mRNA

NCBI chr 3:122,909,082...123,028,605
Ensembl chr 3:122,909,082...123,028,605

G

semaphorin 6A

decreases expression
increases expression

Cocaine results in decreased expression of SEMA6A mRNA
Cocaine results in increased expression of SEMA6A mRNA

PMID:15691709 PMID:18000554

NCBI chr 5:116,443,555...116,574,823
Ensembl chr 5:116,443,555...116,574,823

G

semaphorin 6B

increases expression

Cocaine results in increased expression of SEMA6B mRNA

NCBI chr19:4,542,593...4,559,684
Ensembl chr19:4,542,593...4,581,776

G

semaphorin 6C

decreases expression

Cocaine results in decreased expression of SEMA6C mRNA

NCBI chr 1:151,131,685...151,146,631
Ensembl chr 1:151,131,685...151,146,631

G

semaphorin 7A (JohnMiltonHagen blood group)

affects expression

Cocaine affects the expression of SEMA7A mRNA

NCBI chr15:74,409,289...74,433,958
Ensembl chr15:74,409,289...74,433,958

G

septin 2

affects expression

Cocaine affects the expression of SEPTIN2 mRNA

NCBI chr 2:241,315,355...241,354,027
Ensembl chr 2:241,315,100...241,354,027

G

septin 4

decreases expression

Cocaine results in decreased expression of SEPTIN4 mRNA

PMID:12629581 PMID:15009677 PMID:16710320

NCBI chr17:58,520,256...58,544,328
Ensembl chr17:58,520,250...58,544,368

G

septin 8

decreases expression

Cocaine results in decreased expression of SEPTIN8 protein

NCBI chr 5:132,750,819...132,780,083
Ensembl chr 5:132,750,819...132,807,241

G

serpin family F member 2

increases expression

Cocaine results in increased expression of SERPINF2 mRNA

NCBI chr17:1,742,871...1,755,265
Ensembl chr17:1,742,836...1,755,265

G

serpin family I member 1

increases expression

Cocaine results in increased expression of SERPINI1 mRNA

NCBI chr 3:167,735,721...167,825,569
Ensembl chr 3:167,735,243...167,825,569

G

SERTA domain containing 1

affects expression

Cocaine affects the expression of SERTAD1 mRNA

NCBI chr19:40,421,589...40,425,992
Ensembl chr19:40,421,589...40,425,992

G

seizure related 6 homolog like

decreases expression
multiple interactions

Cocaine results in decreased expression of SEZ6L mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of SEZ6L mRNA]

NCBI chr22:26,169,462...26,383,596
Ensembl chr22:26,169,462...26,383,597

G

SFT2 domain containing 2

decreases expression

Cocaine results in decreased expression of SFT2D2 mRNA

NCBI chr 1:168,226,004...168,253,021
Ensembl chr 1:168,225,938...168,253,021

G

sarcoglycan beta

increases expression
decreases expression

Cocaine results in increased expression of SGCB mRNA
Cocaine results in decreased expression of SGCB mRNA

PMID:12629581 PMID:18000554

NCBI chr 4:52,020,706...52,038,299
Ensembl chr 4:52,020,706...52,038,299

G

serum/glucocorticoid regulated kinase 1

affects expression

Cocaine affects the expression of SGK1 mRNA

NCBI chr 6:134,169,256...134,318,112
Ensembl chr 6:134,169,248...134,318,112

G

serum/glucocorticoid regulated kinase family member 3

increases expression

Cocaine results in increased expression of SGK3 mRNA

NCBI chr 8:66,712,781...66,862,022
Ensembl chr 8:66,712,734...66,862,022

G

SH3 domain containing GRB2 like 1, endophilin A2

affects expression

Cocaine affects the expression of SH3GL1 mRNA

NCBI chr19:4,360,370...4,400,547
Ensembl chr19:4,360,370...4,400,547

G

SH3 and multiple ankyrin repeat domains 2

decreases expression

Cocaine results in decreased expression of SHANK2 mRNA

NCBI chr11:70,467,854...71,253,228
Ensembl chr11:70,467,854...71,252,577

G

SH3 and multiple ankyrin repeat domains 3

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of SHANK3 mRNA

NCBI chr22:50,672,823...50,733,212
Ensembl chr22:50,674,415...50,733,212

G

shisa like 2B

decreases expression

Cocaine results in decreased expression of SHISAL2B mRNA

NCBI chr 5:64,690,503...64,718,190
Ensembl chr 5:64,690,442...64,718,190

G

sigma non-opioid intracellular receptor 1

multiple interactions
increases response to substance
decreases response to substance
affects binding

1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; [Cocaine binds to SIGMAR1 protein] affects the folding of [SIGMAR1 protein binds to DRD1 protein]; Cocaine affects the localization of [DRD1 protein binds to SIGMAR1 protein]; Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cocaine promotes the reaction [DRD1 protein binds to SIGMAR1 protein]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]
SIGMAR1 mRNA results in increased susceptibility to Cocaine
SIGMAR1 gene mutant form results in decreased susceptibility to Cocaine
Cocaine results in increased activity of and results in increased localization of SIGMAR1 protein; methyl-beta-cyclodextrin inhibits the reaction [Cocaine results in increased localization of SIGMAR1 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]

PMID:11006959 PMID:11426838 PMID:12128006 PMID:20354174 PMID:20956312

NCBI chr 9:34,634,722...34,637,787
Ensembl chr 9:34,634,722...34,637,844

G

suppressor of IKBKE 1

affects expression

Cocaine affects the expression of SIKE1 mRNA

NCBI chr 1:114,769,479...114,780,685
Ensembl chr 1:114,769,479...114,780,685

G

SIM bHLH transcription factor 2

decreases expression

Cocaine results in decreased expression of SIM2 mRNA

NCBI chr21:36,699,115...36,749,917
Ensembl chr21:36,699,115...36,749,917

G

signal induced proliferation associated 1 like 1

affects expression

Cocaine affects the expression of SIPA1L1 mRNA

NCBI chr14:71,320,476...71,741,209
Ensembl chr14:71,320,449...71,741,229

G

sirtuin 1

increases expression

cocaine increases expression of Sirt1 protein in nucleus accumbens

RGD

NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390

G

sirtuin 2

increases expression

cocaine increases expression of Sirt2 protein in caudate putamen

RGD

NCBI chr19:38,878,555...38,899,618
Ensembl chr19:38,878,555...38,899,862

G

SIVA1 apoptosis inducing factor

affects expression

Cocaine affects the expression of SIVA1 mRNA

NCBI chr14:104,753,147...104,759,654
Ensembl chr14:104,753,147...104,768,494

G

Src like adaptor 2

decreases expression

Cocaine results in decreased expression of SLA2 mRNA

NCBI chr20:36,612,318...36,646,196
Ensembl chr20:36,612,318...36,646,196

G

solute carrier family 10 member 1

increases expression

Cocaine results in increased expression of SLC10A1 mRNA

NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241

G

solute carrier family 12 member 1

affects expression

Cocaine affects the expression of SLC12A1 mRNA

NCBI chr15:48,206,302...48,304,078
Ensembl chr15:48,178,438...48,304,078

G

solute carrier family 12 member 8

affects expression
decreases expression

Cocaine affects the expression of SLC12A8 mRNA
Cocaine results in decreased expression of SLC12A8 mRNA

PMID:20187946 PMID:27899881

NCBI chr 3:125,082,644...125,212,748
Ensembl chr 3:125,082,636...125,212,864

G

solute carrier family 14 member 1 (Kidd blood group)

affects expression

Cocaine affects the expression of SLC14A1 mRNA

NCBI chr18:45,724,181...45,752,520
Ensembl chr18:45,687,025...45,752,520

G

solute carrier family 14 member 2

affects expression

Cocaine affects the expression of SLC14A2 mRNA

NCBI chr18:45,167,963...45,683,688
Ensembl chr18:45,212,995...45,683,688

G

solute carrier family 16 member 10

decreases expression

Cocaine results in decreased expression of SLC16A10 mRNA

NCBI chr 6:111,087,503...111,231,194
Ensembl chr 6:111,087,503...111,231,194

G

solute carrier family 16 member 3

decreases expression

Cocaine results in decreased expression of SLC16A3 mRNA

NCBI chr17:82,217,934...82,240,086
Ensembl chr17:82,217,934...82,261,129

G

solute carrier family 16 member 6

decreases expression

Cocaine results in decreased expression of SLC16A6 mRNA

NCBI chr17:68,267,026...68,291,479
Ensembl chr17:68,267,026...68,291,267

G

solute carrier family 16 member 8

decreases expression

Cocaine results in decreased expression of SLC16A8 mRNA

NCBI chr22:38,078,137...38,084,184
Ensembl chr22:38,078,134...38,084,184

G

solute carrier family 17 member 6

increases expression

Cocaine results in increased expression of SLC17A6 protein

NCBI chr11:22,338,381...22,379,503
Ensembl chr11:22,338,381...22,379,503

G

solute carrier family 17 member 7

increases expression

Cocaine results in increased expression of SLC17A7 protein

NCBI chr19:49,429,401...49,441,527
Ensembl chr19:49,429,401...49,442,360

G

solute carrier family 17 member 8

affects response to substance

SLC17A8 protein affects the susceptibility to Cocaine

NCBI chr12:100,357,074...100,422,055
Ensembl chr12:100,357,074...100,422,055

G

solute carrier family 18 member A2

decreases expression
increases expression
affects response to substance

Cocaine results in decreased expression of SLC18A2 protein
Cocaine results in increased expression of SLC18A2 protein
SLC18A2 protein affects the susceptibility to Cocaine

PMID:12505801 PMID:12716422 PMID:25100957

NCBI chr10:117,241,114...117,279,430
Ensembl chr10:117,241,093...117,279,430

G

solute carrier family 1 member 2

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [Cocaine results in decreased expression of SLC1A2 protein]; Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC1A2 protein]

NCBI chr11:35,251,205...35,420,507
Ensembl chr11:35,251,205...35,420,063

G

solute carrier family 1 member 4

affects expression

Cocaine affects the expression of SLC1A4 mRNA

NCBI chr 2:64,988,479...65,023,865
Ensembl chr 2:64,988,477...65,023,865

G

solute carrier family 20 member 2

affects expression

Cocaine affects the expression of SLC20A2 mRNA

NCBI chr 8:42,416,475...42,541,954
Ensembl chr 8:42,416,475...42,541,926

G

solute carrier family 22 member 14

decreases expression

Cocaine results in decreased expression of SLC22A14 mRNA

NCBI chr 3:38,278,832...38,318,575
Ensembl chr 3:38,282,294...38,318,575

G

solute carrier family 22 member 25

increases expression
decreases expression

Cocaine results in increased expression of UST5R mRNA
Cocaine results in decreased expression of SLC22A25 mRNA

NCBI chr11:63,158,437...63,243,599
Ensembl chr11:63,158,437...63,243,599

G

solute carrier family 22 member 9

decreases expression

Cocaine results in decreased expression of SLC22A9 mRNA

NCBI chr11:63,369,785...63,410,294
Ensembl chr11:63,369,785...63,410,294

G

solute carrier family 23 member 1

affects expression

Cocaine affects the expression of SLC23A1 mRNA

NCBI chr 5:139,367,196...139,385,676
Ensembl chr 5:139,367,196...139,384,553

G

solute carrier family 24 member 2

affects expression

Cocaine affects the expression of SLC24A2 mRNA

NCBI chr 9:19,507,455...20,307,892
Ensembl chr 9:19,507,452...19,789,037

G

solute carrier family 24 member 4

increases expression

Cocaine results in increased expression of SLC24A4 mRNA

NCBI chr14:92,322,581...92,501,481
Ensembl chr14:92,322,581...92,501,481

G

solute carrier family 25 member 23

decreases expression

Cocaine results in decreased expression of SLC25A23 mRNA

NCBI chr19:6,436,081...6,459,792
Ensembl chr19:6,436,079...6,465,203

G

solute carrier family 25 member 37

increases expression

Cocaine results in increased expression of SLC25A37 mRNA

PMID:15009677 PMID:16710320

NCBI chr 8:23,528,956...23,575,463
Ensembl chr 8:23,528,956...23,575,463

G

solute carrier family 26 member 4

affects expression

Cocaine affects the expression of SLC26A4 mRNA

NCBI chr 7:107,660,828...107,717,809
Ensembl chr 7:107,660,828...107,717,809

G

solute carrier family 29 member 2

decreases expression

Cocaine results in decreased expression of SLC29A2 mRNA

NCBI chr11:66,362,521...66,372,446
Ensembl chr11:66,362,521...66,372,214

G

solute carrier family 32 member 1

increases expression

Cocaine results in increased expression of SLC32A1 mRNA

NCBI chr20:38,724,486...38,729,372
Ensembl chr20:38,724,486...38,729,372

G

solute carrier family 35 member A3

increases expression

Cocaine results in increased expression of SLC35A3 mRNA

NCBI chr 1:99,969,996...100,035,634
Ensembl chr 1:99,969,351...100,035,634

G

solute carrier family 35 member B2

affects expression

Cocaine affects the expression of SLC35B2 mRNA

NCBI chr 6:44,254,101...44,257,890
Ensembl chr 6:44,254,096...44,257,890

G

solute carrier family 39 member 10

decreases expression

Cocaine results in decreased expression of SLC39A10 mRNA

NCBI chr 2:195,613,029...195,737,700
Ensembl chr 2:195,575,977...195,737,702

G

solute carrier family 39 member 11

affects expression

Cocaine affects the expression of SLC39A11 mRNA

NCBI chr17:72,645,949...73,092,688
Ensembl chr17:72,645,949...73,092,712

G

solute carrier family 44 member 1

affects expression

Cocaine affects the expression of SLC44A1 mRNA

NCBI chr 9:105,244,651...105,438,504
Ensembl chr 9:105,244,622...105,439,171

G

solute carrier family 4 member 10

increases expression

Cocaine results in increased expression of SLC4A10 protein

NCBI chr 2:161,624,416...161,985,270
Ensembl chr 2:161,424,332...161,985,282

G

solute carrier family 4 member 3

affects expression

Cocaine affects the expression of SLC4A3 mRNA

NCBI chr 2:219,627,630...219,641,971
Ensembl chr 2:219,627,394...219,641,980

G

solute carrier family 4 member 4

affects expression
increases expression

Cocaine affects the expression of SLC4A4 mRNA
Cocaine results in increased expression of SLC4A4 mRNA

PMID:17898221 PMID:20187946

NCBI chr 4:71,062,660...71,572,083
Ensembl chr 4:71,062,667...71,572,087

G

solute carrier family 5 member 3

affects expression

Cocaine affects the expression of SLC5A3 mRNA

NCBI chr21:34,073,578...34,106,260
Ensembl chr21:34,073,578...34,106,260

G

solute carrier family 66 member 2

affects expression

Cocaine affects the expression of SLC66A2 mRNA

NCBI chr18:79,902,420...79,951,653
Ensembl chr18:79,902,420...79,951,657

G

solute carrier family 6 member 2

decreases activity
multiple interactions
increases phosphorylation
increases expression
increases response to substance

Cocaine results in decreased activity of SLC6A2 protein
Cocaine inhibits the reaction [SLC6A2 protein results in increased import of Biogenic Monoamines analog]; Cocaine inhibits the reaction [SLC6A2 protein results in increased import of Fluorescent Dyes]
Cocaine results in increased phosphorylation of SLC6A2 protein
Cocaine results in increased expression of SLC6A2 protein
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of SLC6A2 protein]; SB 203580 inhibits the reaction [Cocaine results in increased expression of SLC6A2 protein]
SLC6A2 protein results in increased susceptibility to Cocaine

PMID:11082428 PMID:15763139 PMID:15911120 PMID:19728366 PMID:25724654 More...

NCBI chr16:55,655,988...55,706,192
Ensembl chr16:55,655,988...55,707,645

G

solute carrier family 6 member 3

multiple interactions
increases expression
affects response to substance
decreases response to substance
decreases expression
affects expression
increases activity
increases response to substance
affects binding

[Cocaine co-treated with SLC6A3 protein] results in increased expression of FOS protein; [SLC6A3 protein polymorphism affects the susceptibility to Cocaine] which affects the uptake of Dopamine; Butyrates inhibits the reaction [Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]; Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Cocaine inhibits the reaction [Dopamine results in increased activity of SLC6A3 protein]; Cocaine inhibits the reaction [Melitten results in increased localization of SLC6A3 protein]; Cocaine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]; Cocaine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]; Cocaine inhibits the reaction [SLC6A3 protein results in increased transport of phenethylamine]; Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of 4-(4-(dimethylamino)phenyl)-1-methylpyridinium]; Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; Cocaine promotes the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]
Cocaine results in increased expression of SLC6A3 mRNA
SLC6A3 gene mutant form results in decreased susceptibility to Cocaine
Cocaine results in decreased expression of SLC6A3 mRNA
Cocaine results in decreased expression of SLC6A3 protein
Cocaine promotes the reaction [SLC6A3 protein affects the uptake of Dopamine]; Cocaine results in increased phosphorylation of and results in increased activity of SLC6A3 protein; vanoxerine affects the reaction [Cocaine affects the expression of SLC6A3 protein]
Cocaine affects the expression of SLC6A3 mRNA; Cocaine affects the expression of SLC6A3 protein
SLC6A3 mutant form affects the susceptibility to Cocaine; SLC6A3 protein affects the susceptibility to Cocaine
Cocaine results in increased activity of SLC6A3 protein
[Alcohols co-treated with Cocaine] results in increased activity of SLC6A3 protein; Cannabidiol inhibits the reaction [Cocaine results in increased expression of SLC6A3 mRNA]; SLC6A3 mutant form affects the reaction [Cocaine affects the abundance of and affects the uptake of Dopamine]; SLC6A3 protein affects the reaction [[Cocaine co-treated with Alcohols] results in increased uptake of Dopamine]; SLC6A3 protein affects the reaction [Cocaine results in increased uptake of Dopamine]
SLC6A3 gene polymorphism results in increased susceptibility to Cocaine
Cocaine results in increased expression of SLC6A3 protein
Cocaine binds to SLC6A3 protein

PMID:8825631 PMID:9372557 PMID:9736005 PMID:10581411 PMID:11072100 More...

NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440

G

solute carrier family 6 member 4

increases expression
multiple interactions
decreases response to substance
affects expression
increases response to substance
affects response to substance
decreases activity

Cocaine results in increased expression of SLC6A4 protein
Cocaine binds to and results in decreased activity of SLC6A4 protein; Cocaine inhibits the reaction [Serotonin results in increased activity of SLC6A4 protein]; Cocaine inhibits the reaction [SLC6A4 protein results in increased import of Biogenic Monoamines analog]; Cocaine inhibits the reaction [SLC6A4 protein results in increased import of Fluorescent Dyes]; Cocaine inhibits the reaction [SLC6A4 protein results in increased uptake of 4-(4-(dimethylamino)phenyl)-1-methylpyridinium]
SLC6A4 results in decreased susceptibility to Cocaine
Cocaine affects the expression of SLC6A4 mRNA
SLC6A4 gene mutant form results in increased susceptibility to Cocaine
SLC6A4 mutant form affects the susceptibility to Cocaine
Cocaine results in decreased activity of SLC6A4 protein

PMID:11072100 PMID:11207425 PMID:11320258 PMID:16272152 PMID:18321529 More...

NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002

G

solute carrier family 7 member 11

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [Cocaine results in decreased expression of SLC7A11 protein]; Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC7A11 protein]

NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349

G

solute carrier family 9 member A2

decreases expression

Cocaine results in decreased expression of SLC9A2 mRNA

NCBI chr 2:102,619,553...102,711,355
Ensembl chr 2:102,619,553...102,711,355

G

SLIT and NTRK like family member 1

increases expression

Cocaine results in increased expression of SLITRK1 mRNA

NCBI chr13:83,877,205...83,882,474
Ensembl chr13:83,877,205...83,882,474

G

STE20 like kinase

affects expression

Cocaine affects the expression of SLK mRNA

NCBI chr10:103,967,140...104,029,233
Ensembl chr10:103,967,140...104,029,233

G

SMAD family member 1

multiple interactions

[Cocaine co-treated with Cocaine deficiency] inhibits the reaction [SMURF1 protein binds to SMAD1 protein modified form]; [Cocaine co-treated with Cocaine deficiency] results in decreased ubiquitination of SMAD1 protein modified form; [Cocaine co-treated with Cocaine deficiency] results in increased expression of and results in increased phosphorylation of SMAD1 protein

NCBI chr 4:145,480,770...145,559,176
Ensembl chr 4:145,481,194...145,559,176

G

SMAD family member 3

multiple interactions

Cocaine deficiency promotes the reaction [SMARCA4 protein binds to SMAD3 protein]

NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173

G

SMAD family member 5

multiple interactions

[Cocaine co-treated with Cocaine deficiency] inhibits the reaction [SMURF1 protein binds to SMAD5 protein modified form]; [Cocaine co-treated with Cocaine deficiency] results in increased expression of and results in increased phosphorylation of SMAD5 protein

NCBI chr 5:136,132,845...136,182,733
Ensembl chr 5:136,132,845...136,188,747

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

increases expression

Cocaine results in increased expression of SMARCA2 mRNA

NCBI chr 9:2,015,347...2,193,624
Ensembl chr 9:1,980,290...2,193,624

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

increases expression
multiple interactions

Cocaine deficiency results in increased expression of SMARCA4 protein
[Cocaine co-treated with Cocaine deficiency] promotes the reaction [RUNX2 protein binds to SMARCA4 promoter]; Cocaine deficiency promotes the reaction [SMARCA4 protein binds to CTNNB1 promoter]; Cocaine deficiency promotes the reaction [SMARCA4 protein binds to DBN1 promoter]; Cocaine deficiency promotes the reaction [SMARCA4 protein binds to MEF2D promoter]; Cocaine deficiency promotes the reaction [SMARCA4 protein binds to SMAD3 protein]

PMID:27422367 PMID:30158054

NCBI chr19:10,961,030...11,062,273
Ensembl chr19:10,960,932...11,079,426

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

increases expression
multiple interactions

Cocaine results in increased expression of SMARCA5 mRNA
[SMARCA5 protein co-treated with BAZ1B protein] results in increased susceptibility to Cocaine

NCBI chr 4:143,513,702...143,557,486
Ensembl chr 4:143,513,702...143,557,486

G

smoothelin

affects expression

Cocaine affects the expression of SMTN mRNA

NCBI chr22:31,064,118...31,104,624
Ensembl chr22:31,064,105...31,104,757

G

SMAD specific E3 ubiquitin protein ligase 1

multiple interactions

[Cocaine co-treated with Cocaine deficiency] inhibits the reaction [SMURF1 protein binds to RHOA protein]; [Cocaine co-treated with Cocaine deficiency] inhibits the reaction [SMURF1 protein binds to SMAD1 protein modified form]; [Cocaine co-treated with Cocaine deficiency] inhibits the reaction [SMURF1 protein binds to SMAD5 protein modified form]; [Cocaine co-treated with Cocaine deficiency] results in decreased expression of SMURF1 protein

NCBI chr 7:99,027,440...99,144,108
Ensembl chr 7:99,027,440...99,144,108

G

snail family transcriptional repressor 3

increases expression

Cocaine results in increased expression of SNAI3 mRNA

NCBI chr16:88,677,688...88,686,507
Ensembl chr16:88,677,688...88,686,507

G

synaptosome associated protein 91

affects expression

Cocaine affects the expression of SNAP91 mRNA

NCBI chr 6:83,552,885...83,709,393
Ensembl chr 6:83,552,880...83,709,691

G

small nuclear RNA activating complex polypeptide 2

affects expression

Cocaine affects the expression of SNAPC2 mRNA

NCBI chr19:7,920,338...7,923,250
Ensembl chr19:7,920,338...7,923,250

G

synuclein alpha

increases expression
affects expression

Cocaine results in increased expression of SNCA mRNA; Cocaine results in increased expression of SNCA protein
Cocaine affects the expression of SNCA protein

PMID:12684441 PMID:16110277 PMID:18055133 PMID:19393250

NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315

G

synuclein alpha interacting protein

increases expression

Cocaine results in increased expression of SNCAIP mRNA

NCBI chr 5:122,311,353...122,464,219
Ensembl chr 5:122,311,354...122,464,219

G

synuclein beta

affects expression

Cocaine affects the expression of SNCB mRNA

NCBI chr 5:176,620,082...176,630,534
Ensembl chr 5:176,620,082...176,630,556

G

staphylococcal nuclease and tudor domain containing 1

increases expression

Cocaine results in increased expression of SND1 protein

NCBI chr 7:127,652,194...128,092,593
Ensembl chr 7:127,652,194...128,092,609

G

syntaphilin

affects expression

Cocaine affects the expression of SNPH mRNA

NCBI chr20:1,266,294...1,309,327
Ensembl chr20:1,266,280...1,309,328

G

small nuclear ribonucleoprotein U5 subunit 200

affects expression

Cocaine affects the expression of SNRNP200 mRNA

NCBI chr 2:96,274,338...96,305,546
Ensembl chr 2:96,274,338...96,321,271

G

syntrophin gamma 2

increases expression
decreases expression

Cocaine results in increased expression of SNTG2 mRNA
Cocaine results in decreased expression of SNTG2 mRNA

PMID:17898221 PMID:27899881

NCBI chr 2:950,849...1,367,613
Ensembl chr 2:950,849...1,367,613

G

sorting nexin 27

increases expression

Cocaine results in increased expression of SNX27 mRNA alternative form

NCBI chr 1:151,612,050...151,699,080
Ensembl chr 1:151,612,006...151,699,091

G

superoxide dismutase 1

decreases expression
multiple interactions
increases activity

Cocaine results in decreased expression of SOD1 mRNA
GPX1 affects the reaction [Cocaine results in increased activity of SOD1 protein]

PMID:12629581 PMID:30027653

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

superoxide dismutase 2

increases activity
multiple interactions

Cocaine results in increased activity of SOD2 protein
GPX1 affects the reaction [Cocaine results in increased activity of SOD2 protein]

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

SON DNA and RNA binding protein

affects expression

Cocaine affects the expression of SON mRNA

NCBI chr21:33,543,038...33,577,481
Ensembl chr21:33,543,038...33,577,481

G

sortilin related VPS10 domain containing receptor 3

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in increased expression of SORCS3 mRNA

NCBI chr10:104,641,290...105,265,242
Ensembl chr10:104,641,290...105,265,242

G

sortilin related receptor 1

decreases expression

Cocaine results in decreased expression of SORL1 mRNA

NCBI chr11:121,452,314...121,633,763
Ensembl chr11:121,452,314...121,633,763

G

SRY-box transcription factor 30

decreases expression

Cocaine results in decreased expression of SOX30 mRNA

NCBI chr 5:157,625,679...157,671,480
Ensembl chr 5:157,625,679...157,671,480

G

Sp1 transcription factor

affects expression

Cocaine affects the expression of SP1 mRNA; Cocaine affects the expression of SP1 protein

PMID:16179556 PMID:20187946

NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446

G

sperm acrosome associated 9

increases expression

Cocaine results in increased expression of SPACA9 mRNA

NCBI chr 9:132,878,344...132,890,314
Ensembl chr 9:132,878,027...132,890,201

G

sperm associated antigen 4

affects expression

Cocaine affects the expression of SPAG4 mRNA

NCBI chr20:35,615,829...35,621,094
Ensembl chr20:35,615,829...35,621,094

G

SPARC like 1

affects expression

Cocaine affects the expression of SPARCL1 mRNA

NCBI chr 4:87,473,335...87,529,376
Ensembl chr 4:87,473,335...87,531,061

G

spermatogenesis associated serine rich 2 like

increases expression

Cocaine results in increased expression of SPATS2L mRNA

NCBI chr 2:200,305,879...200,482,264
Ensembl chr 2:200,305,881...200,482,264

G

SPG7 matrix AAA peptidase subunit, paraplegin

decreases expression

Cocaine results in decreased expression of SPG7 mRNA

NCBI chr16:89,508,388...89,557,768
Ensembl chr16:89,490,719...89,557,766

G

SPHK1 interactor, AKAP domain containing

multiple interactions

Cocaine promotes the reaction [BAZ1B protein binds to SPHKAP gene]

NCBI chr 2:227,979,955...228,181,687
Ensembl chr 2:227,979,955...228,181,687

G

sprouty related EVH1 domain containing 1

affects expression

Cocaine affects the expression of SPRED1 mRNA

NCBI chr15:38,252,836...38,357,249
Ensembl chr15:38,252,836...38,357,249

G

sprouty RTK signaling antagonist 4

increases expression

Cocaine results in increased expression of SPRY4 mRNA

NCBI chr 5:142,310,430...142,325,021
Ensembl chr 5:142,310,427...142,326,455

G

spectrin alpha, non-erythrocytic 1

increases cleavage

Cocaine results in increased cleavage of SPTAN1 protein

NCBI chr 9:128,552,587...128,633,662
Ensembl chr 9:128,552,558...128,633,662

G

spectrin beta, non-erythrocytic 1

decreases expression

Cocaine results in decreased expression of SPTBN1 mRNA

NCBI chr 2:54,456,327...54,671,446
Ensembl chr 2:54,456,327...54,671,446

G

spectrin beta, non-erythrocytic 2

affects expression

Cocaine affects the expression of SPTBN2 mRNA

NCBI chr11:66,682,497...66,744,682
Ensembl chr11:66,682,497...66,744,670

G

sequestosome 1

decreases expression

Cocaine results in decreased expression of SQSTM1 protein

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

steroid receptor associated and regulated protein

increases expression

Cocaine results in increased expression of SRARP mRNA

NCBI chr 1:16,004,236...16,008,807
Ensembl chr 1:16,004,236...16,008,807

G

SRC proto-oncogene, non-receptor tyrosine kinase

increases phosphorylation
decreases activity
affects expression

Cocaine results in increased phosphorylation of SRC protein
Cocaine results in decreased activity of SRC protein
Cocaine affects the expression of SRC mRNA

PMID:20187946 PMID:20354174 PMID:27506785

NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050

G

SRC kinase signaling inhibitor 1

multiple interactions
increases expression

PRMT6 protein inhibits the reaction [Cocaine results in increased expression of SRCIN1 protein]
Cocaine results in increased expression of SRCIN1 mRNA; Cocaine results in increased expression of SRCIN1 protein

NCBI chr17:38,530,031...38,607,025
Ensembl chr17:38,530,031...38,605,952

G

serine and arginine rich splicing factor 3

decreases expression

Cocaine results in decreased expression of SRSF3 mRNA

NCBI chr 6:36,594,362...36,605,600
Ensembl chr 6:36,594,353...36,605,600

G

small RNA binding exonuclease protection factor La

affects expression

Cocaine affects the expression of SSB mRNA

NCBI chr 2:169,798,871...169,812,064
Ensembl chr 2:169,791,933...169,812,064

G

signal sequence receptor subunit 4

decreases expression

Cocaine results in decreased expression of SSR4 mRNA

NCBI chr X:153,794,159...153,798,512
Ensembl chr X:153,793,516...153,798,499

G

somatostatin receptor 1

affects expression

Cocaine affects the expression of SSTR1 mRNA

NCBI chr14:38,207,904...38,213,067
Ensembl chr14:38,207,904...38,213,067

G

somatostatin receptor 2

affects expression
increases expression

Cocaine affects the expression of SSTR2 mRNA
Cocaine results in increased expression of SSTR2 mRNA

PMID:20187946 PMID:27899881

NCBI chr17:73,165,010...73,176,633
Ensembl chr17:73,165,010...73,176,633

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

increases expression

Cocaine results in increased expression of ST3GAL6 mRNA

NCBI chr 3:98,732,262...98,795,852
Ensembl chr 3:98,732,236...98,821,201

G

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

decreases expression

Cocaine results in decreased expression of ST6GALNAC4 mRNA

NCBI chr 9:127,907,886...127,917,041
Ensembl chr 9:127,907,886...127,917,041

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3

increases expression

Cocaine deficiency results in increased expression of ST8SIA3 mRNA

NCBI chr18:57,352,557...57,368,931
Ensembl chr18:57,352,557...57,371,731

G

signal transducer and activator of transcription 3

increases phosphorylation
multiple interactions

Cocaine results in increased phosphorylation of STAT3 protein
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased phosphorylation of STAT3 protein]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cocaine results in increased phosphorylation of STAT3 protein]; IL6 protein affects the reaction [Cocaine results in increased phosphorylation of STAT3 protein]; TNF protein affects the reaction [Cocaine results in increased phosphorylation of STAT3 protein]

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

signal transducer and activator of transcription 5B

affects expression

Cocaine affects the expression of STAT5B mRNA

NCBI chr17:42,199,177...42,288,370
Ensembl chr17:42,199,176...42,288,633

G

STEAP4 metalloreductase

decreases expression

Cocaine results in decreased expression of STEAP4 mRNA

NCBI chr 7:88,270,892...88,306,894
Ensembl chr 7:88,270,892...88,306,894

G

serine/threonine kinase 40

affects expression

Cocaine affects the expression of STK40 mRNA

NCBI chr 1:36,339,628...36,385,924
Ensembl chr 1:36,339,624...36,385,924

G

striatin interacting protein 2

increases expression

Cocaine deficiency results in increased expression of STRIP2 mRNA

NCBI chr 7:129,434,432...129,488,399
Ensembl chr 7:129,434,432...129,488,399

G

syntaxin 1B

affects expression
increases expression

Cocaine affects the expression of STX1B mRNA
Cocaine results in increased expression of STX1B mRNA

PMID:16076954 PMID:20187946

NCBI chr16:30,989,256...31,010,638
Ensembl chr16:30,989,256...31,010,638

G

syntaxin binding protein 1

affects expression

Cocaine affects the expression of STXBP1 mRNA

NCBI chr 9:127,611,912...127,696,029
Ensembl chr 9:127,579,370...127,696,027

G

sulfatase 1

decreases expression

Cocaine results in decreased expression of SULF1 mRNA

NCBI chr 8:69,466,781...69,660,912
Ensembl chr 8:69,466,624...69,660,915

G

SPT5 homolog, DSIF elongation factor subunit

affects expression

Cocaine affects the expression of SUPT5H mRNA

NCBI chr19:39,445,582...39,476,670
Ensembl chr19:39,436,156...39,476,670

G

SUV39H1 histone lysine methyltransferase

multiple interactions

HDAC5 affects the reaction [Cocaine affects the expression of SUV39H1 mRNA]

NCBI chr X:48,695,554...48,709,016
Ensembl chr X:48,695,554...48,709,016

G

syntabulin

decreases expression

Cocaine results in decreased expression of SYBU mRNA

NCBI chr 8:109,573,978...109,691,600
Ensembl chr 8:109,573,978...109,691,791

G

synapsin I

multiple interactions
affects expression
increases expression

SYN1 protein affects the reaction [Cocaine results in increased secretion of Dopamine]
ILK mutant form inhibits the reaction [Cocaine results in increased expression of SYN1 protein]
Cocaine affects the expression of SYN1 mRNA

PMID:16554471 PMID:19629758 PMID:20187946

NCBI chr X:47,571,901...47,619,857
Ensembl chr X:47,571,901...47,619,857

G

synapsin II

multiple interactions

SYN2 protein affects the reaction [Cocaine results in increased secretion of Dopamine]

NCBI chr 3:12,004,388...12,192,032
Ensembl chr 3:12,004,388...12,192,032

G

synapsin III

multiple interactions

SYN3 protein affects the reaction [Cocaine results in increased secretion of Dopamine]

NCBI chr22:32,507,820...33,058,381
Ensembl chr22:32,507,820...33,058,381

G

spectrin repeat containing nuclear envelope protein 1

increases expression
multiple interactions

Cocaine results in increased expression of SYNE1 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of SYNE1 mRNA]

NCBI chr 6:152,121,687...152,637,362
Ensembl chr 6:152,121,687...152,637,801

G

synaptopodin 2

decreases expression

Cocaine results in decreased expression of SYNPO2 mRNA

NCBI chr 4:118,850,681...119,061,247
Ensembl chr 4:118,850,688...119,061,247

G

synaptopodin 2 like

increases expression

Cocaine results in increased expression of SYNPO2L mRNA

NCBI chr10:73,644,886...73,656,029
Ensembl chr10:73,644,881...73,663,803

G

synaptophysin

increases expression

Cocaine results in increased expression of SYP mRNA

NCBI chr X:49,187,815...49,200,193
Ensembl chr X:49,187,815...49,200,218

G

synaptotagmin 1

affects expression

Cocaine affects the expression of SYT1 mRNA

NCBI chr12:78,863,982...79,452,008
Ensembl chr12:78,863,993...79,452,008

G

synaptotagmin 10

increases expression

Cocaine results in increased expression of SYT10 mRNA

NCBI chr12:33,374,238...33,439,819
Ensembl chr12:33,374,238...33,439,819

G

synaptotagmin 11

increases expression

Cocaine results in increased expression of SYT11 mRNA

PMID:16076954 PMID:18000554

NCBI chr 1:155,859,567...155,885,199
Ensembl chr 1:155,859,567...155,885,199

G

synaptotagmin 13

affects response to substance

SYT13 gene SNP affects the susceptibility to Cocaine

NCBI chr11:45,240,302...45,286,341
Ensembl chr11:45,240,302...45,286,341

G

synaptotagmin 2

increases expression
multiple interactions

Cocaine results in increased expression of SYT2 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of SYT2 mRNA]

NCBI chr 1:202,590,596...202,710,454
Ensembl chr 1:202,590,596...202,710,454

G

synaptotagmin 3

increases expression

Cocaine results in increased expression of SYT3 mRNA

NCBI chr19:50,621,977...50,658,105
Ensembl chr19:50,621,307...50,639,881

G

synaptotagmin 4

increases expression

Cocaine results in increased expression of SYT4 mRNA

NCBI chr18:43,267,892...43,277,490
Ensembl chr18:43,267,892...43,277,535

G

synaptotagmin 5

affects expression

Cocaine affects the expression of SYT5 mRNA

NCBI chr19:55,171,196...55,180,289
Ensembl chr19:55,171,196...55,180,289

G

synaptotagmin 7

multiple interactions

[[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of SYT7 protein; Cocaine promotes the reaction [DRD1 protein results in increased expression of SYT7 protein]; Cocaine promotes the reaction [DRD3 protein results in decreased expression of SYT7 protein]

NCBI chr11:61,513,714...61,588,387
Ensembl chr11:61,513,714...61,581,148

G

synaptotagmin 9

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of SYT9 mRNA

NCBI chr11:7,238,778...7,469,043
Ensembl chr11:7,238,778...7,469,043

G

tachykinin precursor 1

affects expression
increases expression

Cocaine affects the expression of TAC1 mRNA
Cocaine deficiency results in increased expression of TAC1 mRNA
Cocaine results in increased expression of TAC1 mRNA

PMID:11072100 PMID:16395306 PMID:17898221 PMID:27126842

NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472

G

transforming acidic coiled-coil containing protein 1

affects expression

Cocaine affects the expression of TACC1 mRNA

NCBI chr 8:38,728,582...38,853,028
Ensembl chr 8:38,728,186...38,853,028

G

tachykinin receptor 1

multiple interactions

HDAC5 affects the reaction [Cocaine affects the expression of TACR1 mRNA]

NCBI chr 2:75,046,463...75,199,520
Ensembl chr 2:75,046,463...75,199,520

G

tachykinin receptor 3

increases response to substance

TACR3 SNP results in increased susceptibility to Cocaine

NCBI chr 4:103,586,031...103,719,985
Ensembl chr 4:103,586,031...103,719,985

G

transgelin 3

decreases expression

Cocaine results in decreased expression of TAGLN3 mRNA

NCBI chr 3:111,998,922...112,013,885
Ensembl chr 3:111,998,739...112,013,887

G

transaldolase 1

increases expression

Cocaine results in increased expression of TALDO1 protein

NCBI chr11:747,464...765,012
Ensembl chr11:747,415...765,012

G

TARBP2 subunit of RISC loading complex

affects expression

Cocaine affects the expression of TARBP2 mRNA

NCBI chr12:53,500,923...53,506,431
Ensembl chr12:53,500,921...53,506,431

G

threonyl-tRNA synthetase 1

affects expression

Cocaine affects the expression of TARS1 mRNA

NCBI chr 5:33,440,696...33,468,091
Ensembl chr 5:33,440,696...33,468,091

G

Tax1 binding protein 3

affects expression

Cocaine affects the expression of TAX1BP3 mRNA

NCBI chr17:3,662,895...3,668,578
Ensembl chr17:3,662,895...3,668,679

G

TBC1 domain family member 14

affects expression

Cocaine affects the expression of TBC1D14 mRNA

NCBI chr 4:6,909,466...7,033,114
Ensembl chr 4:6,909,242...7,033,118

G

TBC1 domain family member 20

affects expression

Cocaine affects the expression of TBC1D20 mRNA

NCBI chr20:435,480...462,533
Ensembl chr20:423,596...462,566

G

TBC1 domain family member 24

increases expression

Cocaine results in increased expression of TBC1D24 protein

NCBI chr16:2,475,127...2,505,730
Ensembl chr16:2,475,051...2,509,560

G

transcription factor 19

decreases expression

Cocaine results in decreased expression of TCF19 mRNA

NCBI chr 6:31,158,589...31,164,215
Ensembl chr 6:31,158,331...31,167,159

G

transcription factor 4

affects expression

Cocaine affects the expression of TCF4 mRNA

NCBI chr18:55,222,185...55,635,957
Ensembl chr18:55,222,185...55,664,787

G

trichohyalin

decreases expression

Cocaine results in decreased expression of TCHH mRNA

NCBI chr 1:152,106,317...152,115,444
Ensembl chr 1:152,106,317...152,115,444

G

TEA domain transcription factor 1

affects expression

Cocaine affects the expression of TEAD1 mRNA

NCBI chr11:12,674,421...12,944,737
Ensembl chr11:12,674,421...12,944,737

G

teneurin transmembrane protein 2

affects expression
decreases expression

Cocaine affects the expression of TENM2 mRNA
Cocaine results in decreased expression of TENM2 mRNA

PMID:17898221 PMID:20187946

NCBI chr 5:166,979,029...168,264,157
Ensembl chr 5:166,979,029...168,264,157

G

teneurin transmembrane protein 3

affects response to substance

TENM3 gene SNP affects the susceptibility to Cocaine

NCBI chr 4:181,447,613...182,803,024
Ensembl chr 4:182,143,987...182,803,024

G

teneurin transmembrane protein 4

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in increased expression of TENM4 mRNA

NCBI chr11:78,652,829...79,441,030
Ensembl chr11:78,652,829...79,441,030

G

testis associated actin remodelling kinase 1

affects expression

Cocaine affects the expression of TESK1 mRNA

NCBI chr 9:35,605,262...35,610,033
Ensembl chr 9:35,605,262...35,610,041

G

transferrin

decreases expression

Cocaine results in decreased expression of TF mRNA

PMID:16076954 PMID:18357522

NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641

G

transcription factor AP-4

increases expression

Cocaine results in increased expression of TFAP4 mRNA

NCBI chr16:4,257,186...4,273,023
Ensembl chr16:4,257,186...4,273,075

G

transcription factor Dp-2

increases expression

Cocaine results in increased expression of TFDP2 mRNA

NCBI chr 3:141,944,428...142,149,544
Ensembl chr 3:141,944,428...142,149,544

G

tuftelin interacting protein 11

affects expression

Cocaine affects the expression of TFIP11 mRNA

NCBI chr22:26,491,240...26,512,473
Ensembl chr22:26,491,225...26,512,505

G

transferrin receptor

increases expression

Cocaine results in increased expression of TFRC mRNA

PMID:15009677 PMID:16710320

NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153

G

transforming growth factor beta 2

increases expression

Cocaine results in increased expression of TGFB2 mRNA

NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619

G

transforming growth factor beta receptor 1

increases expression
multiple interactions

Cocaine results in increased expression of TGFBR1 mRNA
EHMT2 inhibits the reaction [Cocaine results in increased expression of TGFBR1 mRNA]

NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192

G

tyrosine hydroxylase

affects expression
multiple interactions
decreases phosphorylation
increases expression
decreases expression

Cocaine affects the expression of TH protein
resveratrol promotes the reaction [Cocaine results in decreased phosphorylation of TH protein]
Cocaine results in increased expression of TH protein
Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]; Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]
Cocaine results in decreased expression of TH protein

PMID:11391778 PMID:12787079 PMID:18992788 PMID:20729865 PMID:23499958

NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815

G

thimet oligopeptidase 1

affects expression

Cocaine affects the expression of THOP1 mRNA

NCBI chr19:2,785,503...2,815,807
Ensembl chr19:2,785,503...2,815,807

G

thyroid hormone receptor alpha

multiple interactions

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of THRA mRNA

NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867

G

TIAM Rac1 associated GEF 2

decreases expression

Cocaine results in decreased expression of TIAM2 mRNA

NCBI chr 6:154,995,315...155,257,723
Ensembl chr 6:154,832,697...155,257,723

G

translocase of inner mitochondrial membrane 10B

affects expression

Cocaine affects the expression of TIM9B mRNA

NCBI chr11:6,481,501...6,484,681
Ensembl chr11:6,481,501...6,484,681

G

TOR signaling pathway regulator

increases expression

Cocaine results in increased expression of TIPRL mRNA

NCBI chr 1:168,178,962...168,202,109
Ensembl chr 1:168,178,962...168,202,109

G

tight junction protein 2

affects expression

Cocaine affects the expression of TJP2 mRNA

NCBI chr 9:69,121,264...69,255,208
Ensembl chr 9:69,121,264...69,274,615

G

thymidine kinase 1

decreases expression

Cocaine results in decreased expression of TK1 mRNA

NCBI chr17:78,174,079...78,187,204
Ensembl chr17:78,174,091...78,187,233

G

transketolase

affects expression

Cocaine affects the expression of TKT protein

NCBI chr 3:53,224,712...53,256,022
Ensembl chr 3:53,224,712...53,256,052

G

transmembrane p24 trafficking protein 5

increases expression

Cocaine results in increased expression of TMED5 mRNA

NCBI chr 1:93,149,742...93,180,413
Ensembl chr 1:93,149,742...93,180,516

G

transmembrane p24 trafficking protein 9

affects expression

Cocaine affects the expression of TMED9 mRNA

NCBI chr 5:177,592,203...177,597,242
Ensembl chr 5:177,592,203...177,597,242

G

transmembrane protein 14C

increases expression

Cocaine results in increased expression of TMEM14C protein

NCBI chr 6:10,723,070...10,731,127
Ensembl chr 6:10,722,915...10,731,129

G

transmembrane protein 184B

affects expression

Cocaine affects the expression of TMEM184B mRNA

NCBI chr22:38,216,395...38,273,010
Ensembl chr22:38,219,291...38,273,010

G

transmembrane protein 200B

decreases expression

Cocaine results in decreased expression of TMEM200B mRNA

NCBI chr 1:29,119,429...29,123,903
Ensembl chr 1:29,119,429...29,123,903

G

thymopoietin

increases expression

Cocaine results in increased expression of TMPO mRNA

NCBI chr12:98,515,573...98,550,351
Ensembl chr12:98,515,579...98,550,351

G

tumor necrosis factor

multiple interactions
affects response to substance
increases expression
decreases expression
increases secretion

[Cocaine co-treated with Heroin] results in increased expression of TNF protein
TNF protein affects the susceptibility to Cocaine
Cocaine results in increased expression of TNF protein
Cocaine results in increased expression of TNF mRNA; Cocaine results in increased expression of TNF protein
Cocaine results in decreased expression of TNF protein
[IL6 protein affects the susceptibility to Cocaine] which affects the expression of TNF mRNA; [IL6 protein affects the susceptibility to Cocaine] which affects the expression of TNF protein; Cimetidine inhibits the reaction [Cocaine results in increased expression of TNF protein]; Metyrapone inhibits the reaction [Cocaine results in increased expression of TNF protein]; TNF protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; TNF protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; TNF protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; TNF protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]; TNF protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]; TNF protein affects the reaction [Cocaine results in increased expression of BAX protein]; TNF protein affects the reaction [Cocaine results in increased phosphorylation of JAK2 protein]; TNF protein affects the reaction [Cocaine results in increased phosphorylation of STAT3 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]]; TNF protein affects the reaction [IL6 protein affects the susceptibility to Cocaine]
Cocaine results in increased secretion of TNF protein

PMID:10065903 PMID:10864098 PMID:11368239 PMID:11856816 PMID:16766138 More...

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF receptor superfamily member 10a

affects expression

Cocaine affects the expression of TNFRSF10B mRNA

NCBI chr 8:23,190,452...23,225,102
Ensembl chr 8:23,190,452...23,225,102

G

TNF receptor superfamily member 11b

affects expression

Cocaine affects the expression of TNFRSF11B mRNA

NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885

G

TNF receptor superfamily member 14

increases expression

Cocaine results in increased expression of TNFRSF14 mRNA

NCBI chr 1:2,554,234...2,563,829
Ensembl chr 1:2,555,639...2,565,382

G

TNF receptor superfamily member 18

affects expression

Cocaine affects the expression of TNFRSF18 mRNA

NCBI chr 1:1,203,508...1,206,592
Ensembl chr 1:1,203,508...1,206,592

G

TNF receptor superfamily member 1A

affects expression

Cocaine affects the expression of TNFRSF1A mRNA

NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114

G

TNF receptor superfamily member 1B

affects expression

Cocaine affects the expression of TNFRSF1B mRNA

NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228

G

TNF receptor superfamily member 25

affects expression
multiple interactions
increases expression

Cocaine affects the expression of TNFRSF25 mRNA
EHMT2 inhibits the reaction [Cocaine results in increased expression of TNFRSF25 mRNA]

PMID:15681117 PMID:20056891

NCBI chr 1:6,460,786...6,466,173
Ensembl chr 1:6,460,786...6,466,175

G

TNF superfamily member 10

decreases expression

Cocaine results in decreased expression of TNFSF10 mRNA

NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475

G

troponin I3, cardiac type

increases secretion

Cocaine results in increased secretion of TNNI3 protein

NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773

G

transducer of ERBB2, 1

decreases expression

Cocaine results in decreased expression of TOB1 mRNA

NCBI chr17:50,862,223...50,867,978
Ensembl chr17:50,862,223...50,867,978

G

transducer of ERBB2, 2

affects expression

Cocaine affects the expression of TOB2 mRNA

NCBI chr22:41,433,494...41,446,801
Ensembl chr22:41,433,494...41,446,801

G

translocase of outer mitochondrial membrane 20

increases expression

Cocaine results in increased expression of TOMM20 protein

NCBI chr 1:235,109,341...235,128,837
Ensembl chr 1:235,109,341...235,128,837

G

tumor protein p53

affects expression

Cocaine affects the expression of TRP53 mRNA

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

tumor protein p53 inducible nuclear protein 2

decreases expression

Cocaine results in decreased expression of TP53INP2 mRNA

NCBI chr20:34,704,344...34,713,436
Ensembl chr20:34,704,339...34,713,439

G

tropomyosin 3

affects expression

Cocaine affects the expression of TPM3 mRNA

NCBI chr 1:154,155,308...154,192,100
Ensembl chr 1:154,155,308...154,194,648

G

tryptase gamma 1

affects expression

Cocaine affects the expression of TPSG1 mRNA

NCBI chr16:1,221,651...1,225,268
Ensembl chr16:1,221,651...1,225,793

G

TNF receptor associated factor 2

affects expression

Cocaine affects the expression of TRAF2 mRNA

NCBI chr 9:136,881,958...136,926,607
Ensembl chr 9:136,881,912...136,926,607

G

tribbles pseudokinase 1

affects expression

Cocaine affects the expression of TRIB1 mRNA

NCBI chr 8:125,430,358...125,438,403
Ensembl chr 8:125,430,358...125,438,403

G

tripartite motif containing 28

affects expression

Cocaine affects the expression of TRIM28 mRNA

NCBI chr19:58,544,064...58,550,715
Ensembl chr19:58,544,064...58,550,722

G

tripartite motif containing 3

affects expression

Cocaine affects the expression of TRIM3 mRNA

NCBI chr11:6,448,613...6,474,459
Ensembl chr11:6,448,613...6,474,459

G

tripartite motif containing 72

decreases expression

Cocaine results in decreased expression of TRIM72 mRNA

NCBI chr16:31,214,119...31,231,537
Ensembl chr16:31,214,119...31,231,537

G

tRNA methyltransferase 10C, mitochondrial RNase P subunit

affects expression

Cocaine affects the expression of TRMT10C mRNA

NCBI chr 3:101,561,868...101,566,446
Ensembl chr 3:101,561,868...101,566,446

G

tRNA methyltransferase 6 non-catalytic subunit

decreases expression

Cocaine results in decreased expression of TRMT6 mRNA

NCBI chr20:5,937,228...5,950,533
Ensembl chr20:5,937,228...5,950,558

G

transient receptor potential cation channel subfamily C member 4 associated protein

affects expression

Cocaine affects the expression of TRPC4AP mRNA

NCBI chr20:35,002,404...35,092,807
Ensembl chr20:35,002,404...35,092,807

G

TSPO associated protein 1

multiple interactions
increases expression

FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of TSPOAP1 mRNA]

NCBI chr17:58,301,231...58,328,795
Ensembl chr17:58,301,228...58,328,795

G

TSPY like 1

affects expression

Cocaine affects the expression of TSPYL1 mRNA

NCBI chr 6:116,274,858...116,279,930
Ensembl chr 6:116,267,760...116,279,930

G

testis specific serine kinase 2

affects expression

Cocaine affects the expression of TSSK2 mRNA

NCBI chr22:19,131,308...19,132,622
Ensembl chr22:19,131,308...19,132,622

G

tetratricopeptide repeat domain 7B

decreases expression

Cocaine results in decreased expression of TTC7B mRNA

NCBI chr14:90,524,564...90,816,430
Ensembl chr14:90,524,564...90,816,479

G

tubulin alpha 3d

decreases expression

Cocaine results in decreased expression of TUBA3D mRNA

NCBI chr 2:131,476,119...131,482,934
Ensembl chr 2:131,476,119...131,482,934

G

tubulin alpha 4a

decreases expression

Cocaine results in decreased expression of TUBA4A mRNA

NCBI chr 2:219,249,710...219,254,740
Ensembl chr 2:219,249,710...219,277,902

G

tubulin alpha 8

decreases expression

Cocaine results in decreased expression of TUBA8 mRNA

NCBI chr22:18,110,809...18,131,732
Ensembl chr22:18,110,100...18,146,683

G

terminal uridylyl transferase 4

decreases expression

Cocaine results in decreased expression of TUT4 mRNA

NCBI chr 1:52,423,275...52,553,463
Ensembl chr 1:52,408,282...52,553,487

G

thioredoxin 2

affects expression

Cocaine affects the expression of TXN2 mRNA

NCBI chr22:36,467,046...36,481,640
Ensembl chr22:36,467,046...36,481,640

G

thioredoxin domain containing 15

affects expression

Cocaine affects the expression of TXNDC15 mRNA

NCBI chr 5:134,873,770...134,901,635
Ensembl chr 5:134,874,371...134,901,635

G

tyrosine kinase 2

affects response to substance

TYK2 gene SNP affects the susceptibility to Cocaine

NCBI chr19:10,350,533...10,380,572
Ensembl chr19:10,350,533...10,380,608

G

tyrosinase related protein 1

increases expression

Cocaine results in increased expression of TYRP1 mRNA

NCBI chr 9:12,693,385...12,710,285
Ensembl chr 9:12,685,439...12,710,285

G

ubiquitin conjugating enzyme E2 I

increases expression

Cocaine results in increased expression of UBE2I mRNA

NCBI chr16:1,309,152...1,327,017
Ensembl chr16:1,291,444...1,327,018

G

ubiquitin conjugating enzyme E2 M

decreases expression

Cocaine results in decreased expression of UBE2M mRNA

NCBI chr19:58,555,712...58,558,611
Ensembl chr19:58,555,712...58,558,954

G

ubiquitin protein ligase E3A

decreases expression

Cocaine results in decreased expression of UBE3A mRNA

NCBI chr15:25,333,728...25,439,056
Ensembl chr15:25,333,728...25,439,051

G

ubiquitin protein ligase E3 component n-recognin 4

affects expression

Cocaine affects the expression of UBR4 mRNA

NCBI chr 1:19,074,510...19,210,266
Ensembl chr 1:19,074,510...19,210,266

G

upstream binding transcription factor

affects expression

Cocaine affects the expression of UBTF mRNA

NCBI chr17:44,205,040...44,221,304
Ensembl chr17:44,205,033...44,221,626

G

ubiquitin C-terminal hydrolase L1

decreases expression

Cocaine results in decreased expression of UCHL1 mRNA

NCBI chr 4:41,256,928...41,268,455
Ensembl chr 4:41,256,413...41,268,455

G

ubiquitin C-terminal hydrolase L3

affects expression

Cocaine affects the expression of UCHL3 mRNA

NCBI chr13:75,549,502...75,606,020
Ensembl chr13:75,549,483...75,606,020

G

UDP-glucose ceramide glucosyltransferase

increases expression

Cocaine results in increased expression of UGCG mRNA

PMID:15009677 PMID:16710320

NCBI chr 9:111,896,814...111,935,369
Ensembl chr 9:111,896,814...111,935,369

G

ubiquinol-cytochrome c reductase hinge protein

affects expression

Cocaine affects the expression of UQCRH mRNA

NCBI chr 1:46,303,698...46,316,776
Ensembl chr 1:46,303,698...46,316,776

G

USO1 vesicle transport factor

increases expression

Cocaine results in increased expression of USO1 protein

NCBI chr 4:75,724,577...75,814,286
Ensembl chr 4:75,724,577...75,814,286

G

ubiquitin specific peptidase 46

increases expression

Cocaine results in increased expression of USP46 mRNA

NCBI chr 4:52,590,960...52,659,301
Ensembl chr 4:52,590,960...52,659,301

G

ubiquitin specific peptidase 7

increases expression

Cocaine results in increased expression of USP7 mRNA

NCBI chr16:8,892,097...8,963,906
Ensembl chr16:8,892,097...8,975,328

G

ubiquitin specific peptidase 9 X-linked

increases expression
multiple interactions

Cocaine results in increased expression of USP9X mRNA
EHMT2 inhibits the reaction [Cocaine results in increased expression of USP9X mRNA]

NCBI chr X:41,085,445...41,236,579
Ensembl chr X:41,085,445...41,236,579

G

UDP-glucuronate decarboxylase 1

affects expression

Cocaine affects the expression of UXS1 mRNA

NCBI chr 2:106,093,311...106,194,301
Ensembl chr 2:106,093,308...106,194,301

G

VAMP associated protein B and C

decreases expression

Cocaine results in decreased expression of VAPB mRNA

NCBI chr20:58,389,229...58,451,101
Ensembl chr20:58,389,229...58,451,101

G

vesicle amine transport 1

affects expression

Cocaine affects the expression of VAT1 mRNA

NCBI chr17:43,014,607...43,022,385
Ensembl chr17:43,014,607...43,025,123

G

vascular endothelial growth factor A

affects expression

Cocaine affects the expression of VEGFA mRNA

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

G

VGF nerve growth factor inducible

increases expression

Cocaine results in increased expression of VGF mRNA

NCBI chr 7:101,162,509...101,169,952
Ensembl chr 7:101,162,509...101,165,569

G

vitamin K epoxide reductase complex subunit 1 like 1

affects expression

Cocaine affects the expression of VKORC1L1 mRNA

NCBI chr 7:65,865,772...65,959,558
Ensembl chr 7:65,873,074...65,959,563

G

VPS26 retromer complex component B

increases expression

Cocaine results in increased expression of VPS26B protein

NCBI chr11:134,224,671...134,247,788
Ensembl chr11:134,224,671...134,247,788

G

vacuolar protein sorting 4 homolog A

affects expression

Cocaine affects the expression of VPS4A mRNA

NCBI chr16:69,311,350...69,326,939
Ensembl chr16:69,311,350...69,326,939

G

vesicle transport through interaction with t-SNAREs 1A

affects expression

Cocaine affects the expression of VTI1A mRNA

NCBI chr10:112,446,988...112,855,368
Ensembl chr10:112,446,998...112,818,744

G

von Willebrand factor

increases expression

Cocaine results in increased expression of VWF protein

PMID:10493323 PMID:11988210

NCBI chr12:5,948,877...6,124,670
Ensembl chr12:5,948,877...6,124,770

G

tryptophanyl-tRNA synthetase 1

affects expression

Cocaine affects the expression of WARS1 mRNA

NCBI chr14:100,333,790...100,376,327
Ensembl chr14:100,333,790...100,376,805

G

whirlin

affects expression

Cocaine affects the expression of WHRN mRNA

NCBI chr 9:114,402,080...114,505,473
Ensembl chr 9:114,402,080...114,505,473

G

WNK lysine deficient protein kinase 3

multiple interactions
increases expression

EHMT2 inhibits the reaction [Cocaine results in increased expression of WNK3 mRNA]

NCBI chr X:54,192,823...54,358,900
Ensembl chr X:54,192,823...54,358,642

G

Wnt family member 2

decreases expression

Cocaine results in decreased expression of WNT2 mRNA

NCBI chr 7:117,275,451...117,323,058
Ensembl chr 7:117,275,451...117,323,152

G

Wnt family member 5A

multiple interactions

HDAC5 affects the reaction [Cocaine affects the expression of WNT5A mRNA]

NCBI chr 3:55,465,715...55,505,263
Ensembl chr 3:55,465,715...55,490,539

G

Wnt family member 9B

decreases expression

Cocaine results in decreased expression of WNT9B mRNA

NCBI chr17:46,833,189...46,886,738
Ensembl chr17:46,833,201...46,886,730

G

X-box binding protein 1

increases expression

Cocaine results in increased expression of XBP1 mRNA

NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597

G

xanthine dehydrogenase

multiple interactions
increases activity

acetovanillone inhibits the reaction [Cocaine results in increased activity of XDH protein]

NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742

G

XK related 8

affects expression

Cocaine affects the expression of XKR8 mRNA

NCBI chr 1:27,959,973...27,968,093
Ensembl chr 1:27,959,588...27,968,093

G

tyrosyl-tRNA synthetase 2

affects expression

Cocaine affects the expression of YARS2 mRNA

NCBI chr12:32,746,544...32,755,897
Ensembl chr12:32,727,490...32,755,897

G

Y-box binding protein 1

affects expression

Cocaine affects the expression of YBX1 mRNA

NCBI chr 1:42,682,418...42,703,805
Ensembl chr 1:42,682,418...42,703,805

G

Y-box binding protein 3

affects expression

Cocaine affects the expression of YBX3 mRNA

NCBI chr12:10,699,089...10,723,323
Ensembl chr12:10,699,089...10,723,323

G

Yip1 interacting factor homolog A, membrane trafficking protein

affects expression

Cocaine affects the expression of YIF1A mRNA

NCBI chr11:66,284,580...66,289,143
Ensembl chr11:66,284,580...66,289,145

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

increases expression

Cocaine results in increased expression of YWHAE mRNA

NCBI chr17:1,344,275...1,400,222
Ensembl chr17:1,344,275...1,400,222

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta

affects expression
decreases expression

Cocaine affects the expression of YWHAH mRNA
Cocaine results in decreased expression of YWHAH mRNA

PMID:12629581 PMID:20187946

NCBI chr22:31,944,535...31,957,603
Ensembl chr22:31,944,522...31,957,603

G

zinc finger and BTB domain containing 16

affects expression

Cocaine affects the expression of ZBTB16 mRNA

NCBI chr11:114,059,711...114,256,770
Ensembl chr11:114,059,041...114,256,765

G

zinc finger and BTB domain containing 18

affects expression

Cocaine affects the expression of ZBTB18 mRNA

NCBI chr 1:244,048,491...244,057,476
Ensembl chr 1:244,048,547...244,057,476

G

zinc finger and BTB domain containing 22

affects expression

Cocaine affects the expression of ZBTB22 mRNA

NCBI chr 6:33,314,418...33,317,942
Ensembl chr 6:33,314,406...33,317,942

G

zinc finger DHHC-type palmitoyltransferase 8

affects expression

Cocaine affects the expression of ZDHHC8 mRNA

NCBI chr22:20,131,804...20,148,007
Ensembl chr22:20,129,456...20,148,007

G

zinc finger homeobox 2

affects expression

Cocaine affects the expression of ZFHX2 mRNA

NCBI chr14:23,520,857...23,555,952
Ensembl chr14:23,520,857...23,556,192

G

zinc finger protein, FOG family member 1

increases expression
multiple interactions

Cocaine results in increased expression of ZFPM1 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ZFPM1 mRNA]

NCBI chr16:88,451,769...88,537,031
Ensembl chr16:88,453,280...88,537,031

G

zinc finger protein, FOG family member 2

decreases expression

Cocaine results in decreased expression of ZFPM2 mRNA

NCBI chr 8:105,318,438...105,804,539
Ensembl chr 8:104,590,733...105,804,539

G

zinc fingers and homeoboxes 3

affects expression

Cocaine affects the expression of ZHX3 mRNA

NCBI chr20:41,178,455...41,317,731
Ensembl chr20:41,178,448...41,317,731

G

zinc finger protein 148

affects expression

Cocaine affects the expression of ZNF148 mRNA

NCBI chr 3:125,225,669...125,375,354
Ensembl chr 3:125,225,669...125,375,325

G

zinc finger protein 207

increases expression

Cocaine results in increased expression of ZFP207 mRNA

NCBI chr17:32,350,157...32,381,885
Ensembl chr17:32,350,132...32,381,885

G

zinc finger protein 394

affects expression

Cocaine affects the expression of ZNF394 mRNA

NCBI chr 7:99,486,519...99,500,281
Ensembl chr 7:99,473,877...99,504,857

G

zinc finger protein 483

increases expression

Cocaine results in increased expression of ZNF483 mRNA

NCBI chr 9:111,525,179...111,578,136
Ensembl chr 9:111,525,159...111,577,844

deptropine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

dibenzheptropine results in decreased activity of KCNH2 protein

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

ecgonine benzoate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carboxylesterase 1

increases chemical synthesis

CES1 protein results in increased chemical synthesis of benzoylecgonine

NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337

ecgonine methyl ester

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

multiple interactions
increases chemical synthesis
increases abundance

[BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of ecgonine methyl ester
[BCHE protein mutant form results in increased metabolism of Cocaine] which results in increased chemical synthesis of ecgonine methyl ester
BCHE protein mutant form results in increased chemical synthesis of ecgonine methyl ester
BCHE protein mutant form results in increased abundance of ecgonine methyl ester

PMID:25814464 PMID:30080993

NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462

ipratropium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases cleavage

Ipratropium results in increased cleavage of CASP3 protein

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

matrix metallopeptidase 9

multiple interactions

Ipratropium promotes the reaction [Formoterol Fumarate inhibits the reaction [Cadmium results in increased activity of MMP9 protein]]

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

solute carrier family 22 member 1

multiple interactions

Ipratropium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718

G

solute carrier family 22 member 2

multiple interactions

Ipratropium inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638

G

solute carrier family 22 member 3

multiple interactions

Ipratropium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577

G

solute carrier family 22 member 4

multiple interactions

Ipratropium inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]

NCBI chr 5:132,294,394...132,344,190
Ensembl chr 5:132,294,394...132,344,190

G

solute carrier family 22 member 5

multiple interactions

Ipratropium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]

NCBI chr 5:132,369,710...132,395,612
Ensembl chr 5:132,369,710...132,395,613

scopolamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

decreases expression

Scopolamine results in decreased expression of ABCB1 mRNA

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily G member 1

increases expression

Scopolamine results in increased expression of ABCG1 mRNA

NCBI chr21:42,199,689...42,297,244
Ensembl chr21:42,199,689...42,297,244

G

acetylcholinesterase (Yt blood group)

multiple interactions
increases expression
affects activity
increases activity
decreases activity
decreases expression
increases response to substance
affects response to substance

kangshuai yizhi inhibits the reaction [Scopolamine results in increased activity of ACHE protein]
Scopolamine results in increased expression of ACHE mRNA; Scopolamine results in increased expression of ACHE protein
Scopolamine affects the activity of ACHE protein
Scopolamine results in decreased activity of ACHE protein
Ascorbic Acid inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]; Canagliflozin inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; stevioside inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Vitamin E inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]
Scopolamine results in decreased expression of ACHE protein
ACHE protein results in increased susceptibility to Scopolamine
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; acanthoside B inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; ajoene inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; chong-myung-tang inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Donepezil inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; mangiferin inhibits the reaction [Scopolamine results in decreased expression of ACHE protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts affects the reaction [Scopolamine affects the activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of ACHE mRNA]; protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]
ACHE affects the susceptibility to Scopolamine

PMID:11814146 PMID:15301936 PMID:18533140 PMID:18672024 PMID:20673844 More...

NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974

G

adenosine A3 receptor

multiple interactions

[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine

NCBI chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633

G

angiotensinogen

multiple interactions

[AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine

NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576

G

amyloid beta precursor protein binding family A member 1

increases expression

Scopolamine results in increased expression of APBA1 mRNA

NCBI chr 9:69,427,532...69,673,013
Ensembl chr 9:69,427,532...69,672,371

G

amyloid beta precursor like protein 2

increases expression

Scopolamine results in increased expression of APLP2 mRNA

NCBI chr11:130,069,894...130,144,805
Ensembl chr11:130,068,147...130,144,811

G

amyloid beta precursor protein

decreases cleavage

Scopolamine results in decreased cleavage of APP protein

NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128

G

activity regulated cytoskeleton associated protein

decreases expression
decreases expression

Scopolamine results in decreased expression of ARC mRNA
scopolamine decreases expression of Arc mRNA and protein in cerebral cortex and hippocampus

CTD
RGD

PMID:17540011 PMID:24012642

NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479

G

arginase 2

decreases expression

Scopolamine results in decreased expression of ARG2 mRNA

NCBI chr14:67,619,920...67,651,708
Ensembl chr14:67,619,920...67,651,708

G

ADP ribosylation factor like GTPase 4D

decreases expression

Scopolamine results in decreased expression of ARL4D mRNA

NCBI chr17:43,398,993...43,401,137
Ensembl chr17:43,398,993...43,401,137

G

arginine vasopressin

multiple interactions

[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine

NCBI chr20:3,082,556...3,084,724
Ensembl chr20:3,082,556...3,084,724

G

arginine vasopressin receptor 1A

multiple interactions

[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine

NCBI chr12:63,142,759...63,151,201
Ensembl chr12:63,142,759...63,151,201

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Scopolamine results in increased expression of BAX mRNA; Scopolamine results in increased expression of BAX protein
dihydroactinidiolide inhibits the reaction [Scopolamine results in increased expression of BAX protein]; Donepezil inhibits the reaction [Scopolamine results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of BAX mRNA]

PMID:17120751 PMID:26434561 PMID:34371027

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

branched chain amino acid transaminase 1

increases expression

Scopolamine results in increased expression of BCAT1 mRNA

NCBI chr12:24,810,024...24,949,340
Ensembl chr12:24,810,024...24,949,101

G

BCL2 apoptosis regulator

decreases expression
multiple interactions

Scopolamine results in decreased expression of BCL2 mRNA; Scopolamine results in decreased expression of BCL2 protein
dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]

PMID:17120751 PMID:26434561 PMID:34371027

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

brain derived neurotrophic factor

multiple interactions
decreases expression

Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
Scopolamine results in decreased expression of BDNF mRNA; Scopolamine results in decreased expression of BDNF protein
[acanthoside B co-treated with Scopolamine] results in increased expression of BDNF protein; [Tacrine co-treated with Scopolamine] results in increased expression of BDNF protein; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Plant Extracts inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]

PMID:8405262 PMID:8635431 PMID:22096544 PMID:26408985 PMID:26434561 More...

NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058

G

calcium voltage-gated channel subunit alpha1 D

increases expression

Scopolamine results in increased expression of CACNA1D mRNA

NCBI chr 3:53,494,611...53,813,733
Ensembl chr 3:53,328,963...53,813,733

G

calcium/calmodulin dependent protein kinase kinase 2

decreases expression

Scopolamine results in decreased expression of CAMKK2 mRNA

NCBI chr12:121,237,692...121,297,819
Ensembl chr12:121,237,675...121,298,308

G

CART prepropeptide

decreases expression

Scopolamine results in decreased expression of CARTPT mRNA

NCBI chr 5:71,719,275...71,721,045
Ensembl chr 5:71,719,275...71,721,048

G

caspase 3

increases expression
increases activity
multiple interactions

Scopolamine results in increased expression of CASP3 mRNA; Scopolamine results in increased expression of CASP3 protein
Scopolamine results in increased activity of CASP3 protein
dihydroactinidiolide inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]; Donepezil inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CASP3 mRNA]

PMID:17120751 PMID:26434561 PMID:34371027

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

catalase

multiple interactions
increases activity
decreases activity

acanthoside B inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; chong-myung-tang inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Donepezil inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of CAT protein]

PMID:20673844 PMID:27717698 PMID:31077737 PMID:34371027

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

CD3 epsilon subunit of T-cell receptor complex

decreases expression

Scopolamine results in decreased expression of CD3E mRNA

NCBI chr11:118,304,730...118,316,173
Ensembl chr11:118,304,730...118,316,175

G

cyclin dependent kinase like 4

increases expression

Scopolamine results in increased expression of CDKL4 mRNA

NCBI chr 2:39,168,045...39,247,120
Ensembl chr 2:39,168,045...39,243,983

G

choline O-acetyltransferase

decreases activity
multiple interactions

Scopolamine results in decreased activity of CHAT protein
protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]
kangshuai yizhi inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]

PMID:20694781 PMID:26408985 PMID:29133030

NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942

G

cholinergic receptor muscarinic 1

multiple interactions
decreases expression
increases expression

[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine; Canagliflozin affects the reaction [Scopolamine results in decreased expression of CHRM1 protein]
Scopolamine results in increased expression of CHRM1 mRNA
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of CHRM1 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CHRM1 mRNA]

PMID:11553362 PMID:26434561 PMID:28837785 PMID:32001261

NCBI chr11:62,908,679...62,921,878
Ensembl chr11:62,908,679...62,921,807

G

cholinergic receptor muscarinic 4

increases response to substance

CHRM4 protein results in increased susceptibility to Scopolamine

NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,383,789...46,391,776

G

cholinergic receptor muscarinic 5

decreases response to substance

CHRM5 protein results in decreased susceptibility to Scopolamine

NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458

G

cholinergic receptor nicotinic alpha 4 subunit

affects binding
multiple interactions

Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr20:63,343,223...63,361,349
Ensembl chr20:63,343,223...63,378,401

G

cholinergic receptor nicotinic beta 2 subunit

affects binding
multiple interactions

Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 1:154,567,778...154,580,013
Ensembl chr 1:154,567,778...154,580,013

G

cochlin

decreases expression

Scopolamine results in decreased expression of COCH mRNA

NCBI chr14:30,874,559...30,895,615
Ensembl chr14:30,874,514...30,895,065

G

coronin 1B

increases expression

Scopolamine results in increased expression of CORO1B mRNA

NCBI chr11:67,435,510...67,443,809
Ensembl chr11:67,435,510...67,443,821

G

cytochrome c oxidase subunit 5B

increases expression

Scopolamine results in increased expression of COX5B mRNA

NCBI chr 2:97,646,062...97,648,383
Ensembl chr 2:97,646,062...97,648,383

G

cAMP responsive element binding protein 1

decreases phosphorylation
multiple interactions

Scopolamine results in decreased phosphorylation of CREB1 protein
acanthoside B inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]

PMID:26408985 PMID:31077737

NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988

G

crystallin alpha B

increases expression

Scopolamine results in increased expression of CRYAB mRNA

NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722

G

colony stimulating factor 2

multiple interactions
decreases response to substance

IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine]

NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170

G

C-X-C motif chemokine receptor 5

decreases expression

Scopolamine results in decreased expression of CXCR5 mRNA

NCBI chr11:118,883,892...118,897,787
Ensembl chr11:118,883,892...118,897,787

G

dopa decarboxylase

decreases expression

Scopolamine results in decreased expression of DDC mRNA

NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405

G

deoxyguanosine kinase

increases expression

Scopolamine results in increased expression of DGUOK mRNA

NCBI chr 2:73,926,880...73,958,946
Ensembl chr 2:73,926,826...73,958,961

G

iodothyronine deiodinase 2

increases expression

Scopolamine results in increased expression of DIO2 mRNA

NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,526...80,387,757

G

dual specificity phosphatase 5

decreases expression

Scopolamine results in decreased expression of DUSP5 mRNA

NCBI chr10:110,497,907...110,511,533
Ensembl chr10:110,497,907...110,511,533

G

dual specificity phosphatase 6

decreases expression

Scopolamine results in decreased expression of DUSP6 mRNA

NCBI chr12:89,347,235...89,352,501
Ensembl chr12:89,347,235...89,352,501

G

epidermal growth factor receptor

decreases expression

Scopolamine results in decreased expression of EGFR mRNA

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

early growth response 1

multiple interactions
decreases expression

[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of EGR1 mRNA; Scopolamine affects the reaction [SK&F 82958 results in increased expression of EGR1 mRNA]
Scopolamine results in decreased expression of EGR1 protein
Donepezil inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]
Scopolamine results in decreased expression of EGR1 mRNA

PMID:8861055 PMID:17540011 PMID:29133030

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

G

early growth response 2

decreases expression

Scopolamine results in decreased expression of EGR2 mRNA

NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,819,167

G

eukaryotic translation initiation factor 2 subunit alpha

increases expression

Scopolamine results in increased expression of EIF2S1 mRNA

NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516

G

EMAP like 1

decreases expression

Scopolamine results in decreased expression of EML1 mRNA

NCBI chr14:99,737,722...99,942,060
Ensembl chr14:99,737,693...99,942,060

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression
increases expression

[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS mRNA; Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]]; Ro4368554 inhibits the reaction [Scopolamine results in increased expression of FOS protein]; Scopolamine affects the reaction [SK&F 82958 results in increased expression of FOS mRNA]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]
Scopolamine results in decreased expression of FOS protein
Donepezil inhibits the reaction [Scopolamine results in decreased expression of FOS protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein]
Scopolamine results in decreased expression of FOS mRNA

PMID:1393566 PMID:8281324 PMID:8861055 PMID:11337201 PMID:17540011 More...

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

G

gamma-aminobutyric acid type B receptor subunit 1

increases expression

Scopolamine results in increased expression of GABBR1 mRNA

NCBI chr 6:29,602,238...29,633,183
Ensembl chr 6:29,555,629...29,633,976

G

growth associated protein 43

multiple interactions
decreases expression

Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]

NCBI chr 3:115,623,510...115,721,483
Ensembl chr 3:115,623,510...115,721,490

G

glial fibrillary acidic protein

multiple interactions
decreases expression

Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]
Scopolamine results in decreased expression of GFAP mRNA; Scopolamine results in decreased expression of GFAP protein

NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937

G

gap junction protein beta 2

increases expression

Scopolamine results in increased expression of GJB2 mRNA

NCBI chr13:20,187,470...20,192,938
Ensembl chr13:20,187,463...20,192,938

G

glypican 3

decreases expression

Scopolamine results in decreased expression of GPC3 mRNA

NCBI chr X:133,535,745...133,985,594
Ensembl chr X:133,535,745...133,987,100

G

glutamate metabotropic receptor 4

multiple interactions

Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr 6:34,018,643...34,155,622
Ensembl chr 6:34,018,643...34,155,622

G

glutathione-disulfide reductase

decreases activity
multiple interactions

Scopolamine results in decreased activity of GSR protein
Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of GSR protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of GSR protein]

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

glycophorin C (Gerbich blood group)

decreases expression

Scopolamine results in decreased expression of GYPC mRNA

NCBI chr 2:126,656,158...126,696,667
Ensembl chr 2:126,656,133...126,696,667

G

heme oxygenase 1

increases expression
multiple interactions

Scopolamine results in increased expression of HMOX1 protein
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of HMOX1 protein]

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

homer scaffold protein 1

decreases expression

Scopolamine results in decreased expression of HOMER1 mRNA

NCBI chr 5:79,372,636...79,514,134
Ensembl chr 5:79,372,636...79,514,134

G

histamine receptor H1

multiple interactions

[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine]

NCBI chr 3:11,137,238...11,263,557
Ensembl chr 3:11,137,093...11,263,557

G

histamine receptor H2

multiple interactions

[[thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine]

PMID:11640976 PMID:19215234

NCBI chr 5:175,658,071...175,710,756
Ensembl chr 5:175,658,030...175,710,756

G

histamine receptor H3

multiple interactions

[clobenpropit binds to and results in decreased activity of HRH3 protein] which results in decreased susceptibility to Scopolamine

NCBI chr20:62,214,960...62,220,278
Ensembl chr20:62,214,960...62,220,278

G

heat shock protein family A (Hsp70) member 2

increases expression

Scopolamine results in increased expression of HSPA2 mRNA

NCBI chr14:64,535,905...64,543,237
Ensembl chr14:64,535,905...64,546,173

G

5-hydroxytryptamine receptor 1A

multiple interactions

[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine]

NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507

G

5-hydroxytryptamine receptor 2C

increases expression

Scopolamine results in increased expression of HTR2C mRNA

NCBI chr X:114,584,086...114,910,061
Ensembl chr X:114,584,078...114,910,061

G

5-hydroxytryptamine receptor 6

decreases expression

Scopolamine results in decreased expression of HTR6 mRNA

NCBI chr 1:19,664,875...19,680,966
Ensembl chr 1:19,664,875...19,680,966

G

interferon gamma

multiple interactions
increases expression

Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IFNG mRNA]

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

interleukin 10

multiple interactions
decreases expression

acanthoside B inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 1 alpha

decreases response to substance

IL1A protein results in decreased susceptibility to Scopolamine

NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493

G

interleukin 1 beta

increases expression
multiple interactions

Scopolamine results in increased expression of IL1B mRNA; Scopolamine results in increased expression of IL1B protein
Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL1B mRNA]
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of IL1B protein]

PMID:18357464 PMID:19426756 PMID:21161262 PMID:31077737

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 1 receptor antagonist

multiple interactions

IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine]

NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016

G

interleukin 6

multiple interactions
increases expression

Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL6 mRNA]; Scopolamine promotes the reaction [Fatty Acids, Unsaturated deficiency results in increased expression of IL6 mRNA]
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL6 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL6 protein]
Scopolamine results in increased expression of IL6 mRNA; Scopolamine results in increased expression of IL6 protein

PMID:18357464 PMID:21161262 PMID:31077737

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

inositol 1,4,5-trisphosphate receptor type 1

increases expression

Scopolamine results in increased expression of ITPR1 mRNA

NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,506

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]
Scopolamine results in decreased expression of JUN protein
Donepezil inhibits the reaction [Scopolamine results in decreased expression of JUN protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein]

PMID:11337201 PMID:29133030

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

Scopolamine results in decreased expression of JUNB mRNA

NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315

G

potassium voltage-gated channel subfamily A member 4

increases expression

Scopolamine results in increased expression of KCNA4 mRNA

NCBI chr11:30,009,730...30,017,030
Ensembl chr11:30,009,730...30,017,030

G

potassium voltage-gated channel subfamily B member 1

increases expression

Scopolamine results in increased expression of KCNB1 mRNA

PMID:12579815 PMID:15567561

NCBI chr20:49,363,877...49,483,362
Ensembl chr20:49,293,394...49,484,297

G

potassium voltage-gated channel subfamily D member 2

decreases expression

Scopolamine results in decreased expression of KCND2 mRNA

NCBI chr 7:120,272,908...120,750,337
Ensembl chr 7:120,273,175...120,750,337

G

potassium inwardly rectifying channel subfamily J member 3

multiple interactions

Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr 2:154,698,695...154,858,354
Ensembl chr 2:154,697,855...154,858,354

G

KLF transcription factor 2

decreases expression

Scopolamine results in decreased expression of KLF2 mRNA

NCBI chr19:16,324,826...16,328,685
Ensembl chr19:16,324,826...16,328,685

G

KLF transcription factor 4

decreases expression

Scopolamine results in decreased expression of KLF4 mRNA

NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482

G

leucyl and cystinyl aminopeptidase

multiple interactions

[AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine

NCBI chr 5:96,936,080...97,037,513
Ensembl chr 5:96,935,394...97,037,513

G

MAP kinase activating death domain

increases expression

Scopolamine results in increased expression of MADD mRNA

NCBI chr11:47,269,188...47,330,031
Ensembl chr11:47,269,161...47,330,031

G

microtubule associated protein 2

decreases expression
multiple interactions

Scopolamine results in decreased expression of MAP2 protein
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]

NCBI chr 2:209,424,047...209,734,112
Ensembl chr 2:209,424,047...209,734,147

G

microtubule associated protein tau

decreases expression

Scopolamine results in decreased expression of MAPT mRNA

NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334

G

myelin basic protein

multiple interactions
decreases expression

Melatonin inhibits the reaction [Scopolamine results in decreased expression of MBP protein]

NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683

G

mucin 5AC, oligomeric mucus/gel-forming

decreases expression

Scopolamine results in decreased expression of MUC5AC protein

PMID:18357464 PMID:21161262

NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138

G

neurofilament heavy chain

multiple interactions
decreases expression

Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]

NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390

G

NFE2 like bZIP transcription factor 2

decreases expression
multiple interactions

Scopolamine results in decreased expression of NFE2L2 protein
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein]

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nerve growth factor

decreases response to substance
multiple interactions
increases response to substance

NGF protein results in decreased susceptibility to Scopolamine
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]
NGF protein results in increased susceptibility to Scopolamine

PMID:1661212 PMID:8635431 PMID:16405025

NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770

G

nitric oxide synthase 2

multiple interactions
increases expression

acanthoside B inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]

PMID:26408985 PMID:31077737

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

NOVA alternative splicing regulator 1

multiple interactions

Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA]

NCBI chr14:26,443,090...26,598,033
Ensembl chr14:26,443,090...26,598,033

G

NOVA alternative splicing regulator 2

multiple interactions

Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NOVA2 mRNA]

NCBI chr19:45,933,734...45,973,865
Ensembl chr19:45,933,734...45,974,044

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
decreases expression

Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of NQO1 protein]

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

increases expression

Scopolamine results in increased expression of NQO2 mRNA

NCBI chr 6:2,999,894...3,019,755
Ensembl chr 6:2,987,987...3,019,755

G

nuclear receptor subfamily 1 group D member 1

decreases expression

Scopolamine results in decreased expression of NR1D1 mRNA

NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589

G

nuclear receptor subfamily 4 group A member 1

decreases expression

Scopolamine results in decreased expression of NR4A1 mRNA

NCBI chr12:52,022,832...52,059,503
Ensembl chr12:52,022,832...52,059,507

G

neurotrophin 3

multiple interactions

Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NTF3 mRNA]

NCBI chr12:5,430,332...5,495,299
Ensembl chr12:5,432,108...5,521,536

G

neurotrophic receptor tyrosine kinase 2

multiple interactions
decreases expression

Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]
Scopolamine results in decreased expression of NTRK2 protein
[acanthoside B co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; [Tacrine co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein]

PMID:8635431 PMID:29476728 PMID:31077737

NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751

G

neurotrophic receptor tyrosine kinase 3

multiple interactions

Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA]

NCBI chr15:87,859,751...88,256,739
Ensembl chr15:87,859,751...88,256,791

G

programmed cell death 4

increases expression

Scopolamine results in increased expression of PDCD4 mRNA

NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006

G

prodynorphin

decreases response to substance
multiple interactions
increases expression

PDYN protein modified form results in decreased susceptibility to Scopolamine
MR 2266 inhibits the reaction [PDYN protein modified form results in decreased susceptibility to Scopolamine]
Scopolamine results in increased expression of PDYN mRNA

PMID:7768285 PMID:17540011

NCBI chr20:1,978,756...1,994,285
Ensembl chr20:1,978,757...1,994,285

G

proenkephalin

multiple interactions

Scopolamine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]

NCBI chr 8:56,440,957...56,446,641
Ensembl chr 8:56,436,674...56,446,671

G

phosphoglycerate mutase 1

decreases expression

Scopolamine results in decreased expression of PGAM1 mRNA

NCBI chr10:97,426,191...97,433,444
Ensembl chr10:97,426,191...97,433,444

G

prolyl endopeptidase

increases response to substance
increases expression
multiple interactions

PREP protein results in increased susceptibility to Scopolamine
Scopolamine results in increased expression of PREP protein
Piracetam inhibits the reaction [Scopolamine results in increased expression of PREP protein]

PMID:17244263 PMID:18318186

NCBI chr 6:105,273,218...105,403,082
Ensembl chr 6:105,273,218...105,454,062

G

protein activator of interferon induced protein kinase EIF2AK2

decreases expression

Scopolamine results in decreased expression of PRKRA mRNA

NCBI chr 2:178,431,414...178,451,175
Ensembl chr 2:178,431,292...178,451,512

G

presenilin 2

decreases expression

Scopolamine results in decreased expression of PSEN2 mRNA

NCBI chr 1:226,870,616...226,903,668
Ensembl chr 1:226,870,184...226,927,726

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

Scopolamine results in increased expression of PTGS2 protein
acanthoside B inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]

PMID:26408985 PMID:31077737

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

RAB14, member RAS oncogene family

increases expression

Scopolamine results in increased expression of RAB14 mRNA

NCBI chr 9:121,178,133...121,201,869
Ensembl chr 9:121,178,133...121,223,014

G

Rap guanine nucleotide exchange factor 3

decreases expression

Scopolamine results in decreased expression of RAPGEF3 mRNA

NCBI chr12:47,734,363...47,758,880
Ensembl chr12:47,734,363...47,771,040

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

mangiferin inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]; Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein; timosaponin AIII inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]

PMID:19182383 PMID:19426756

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

RRAD and GEM like GTPase 2

decreases expression

Scopolamine results in decreased expression of REM2 mRNA

NCBI chr14:22,883,222...22,887,678
Ensembl chr14:22,883,222...22,887,678

G

regulator of G protein signaling 7 binding protein

decreases expression

Scopolamine results in decreased expression of RGS7BP mRNA

NCBI chr 5:64,506,015...64,612,319
Ensembl chr 5:64,506,015...64,612,319

G

roundabout guidance receptor 3

decreases expression

Scopolamine results in decreased expression of ROBO3 mRNA

NCBI chr11:124,865,432...124,881,471
Ensembl chr11:124,865,432...124,881,471

G

Ras related GTP binding A

increases expression

Scopolamine results in increased expression of RRAGA mRNA

NCBI chr 9:19,049,427...19,051,025
Ensembl chr 9:19,049,427...19,051,025

G

S100 calcium binding protein A4

decreases expression

Scopolamine results in decreased expression of S100A4 mRNA

NCBI chr 1:153,543,621...153,545,806
Ensembl chr 1:153,543,613...153,550,136

G

sphingosine-1-phosphate receptor 1

increases expression

Scopolamine results in increased expression of S1PR1 mRNA

NCBI chr 1:101,236,899...101,242,313
Ensembl chr 1:101,236,865...101,243,713

G

secretory carrier membrane protein 2

increases expression

Scopolamine results in increased expression of SCAMP2 mRNA

NCBI chr15:74,843,730...74,873,365
Ensembl chr15:74,843,730...74,873,365

G

sigma non-opioid intracellular receptor 1

multiple interactions

[2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine; [igmesine binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine

NCBI chr 9:34,634,722...34,637,787
Ensembl chr 9:34,634,722...34,637,844

G

solute carrier family 47 member 1

multiple interactions

Scopolamine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034

G

solute carrier family 47 member 2

multiple interactions

Scopolamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr17:19,678,317...19,718,979
Ensembl chr17:19,678,288...19,718,979

G

sulfotransferase family 1A member 1

increases expression

Scopolamine results in increased expression of SULT1A1 mRNA

NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044

G

synaptophysin

multiple interactions
decreases expression
increases expression

cyclo-L-glycyl-L-2-allylproline inhibits the reaction [Scopolamine results in increased expression of SYP protein]
dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of SYP mRNA]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of SYP mRNA]

PMID:20188767 PMID:34371027

NCBI chr X:49,187,815...49,200,193
Ensembl chr X:49,187,815...49,200,218

G

tachykinin precursor 1

decreases response to substance

TAC1 protein modified form results in decreased susceptibility to Scopolamine

NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472

G

tumor necrosis factor

multiple interactions
increases expression

acanthoside B inhibits the reaction [Scopolamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [Scopolamine results in increased expression of TNF protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of TNF protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of TNF protein]
Scopolamine results in increased expression of TNF mRNA
Scopolamine results in increased expression of TNF mRNA; Scopolamine results in increased expression of TNF protein

PMID:18357464 PMID:19182383 PMID:19426756 PMID:21161262 PMID:31077737

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

trinucleotide repeat containing adaptor 6A

decreases expression

Scopolamine results in decreased expression of TNRC6A mRNA

NCBI chr16:24,610,205...24,826,218
Ensembl chr16:24,610,209...24,827,632

G

TPD52 like 1

increases expression

Scopolamine results in increased expression of TPD52L1 mRNA

NCBI chr 6:125,153,773...125,264,407
Ensembl chr 6:125,119,049...125,264,407

G

VGF nerve growth factor inducible

decreases expression

Scopolamine results in decreased expression of VGF mRNA

NCBI chr 7:101,162,509...101,169,952
Ensembl chr 7:101,162,509...101,165,569

G

vasoactive intestinal peptide

decreases response to substance

VIP protein results in decreased susceptibility to Scopolamine

NCBI chr 6:152,750,797...152,759,760
Ensembl chr 6:152,750,797...152,759,765

tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atropine results in decreased activity of ABCB11 protein

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

[Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA

NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675

G

acetylcholinesterase (Yt blood group)

multiple interactions

Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]

PMID:2241428 PMID:10421444 PMID:17963125 PMID:20105433 PMID:21600273 More...

NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974

G

adenylate cyclase 5

increases response to substance

ADCY5 protein results in increased susceptibility to Atropine

NCBI chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090

G

aquaporin 5

multiple interactions

Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein]

NCBI chr12:49,961,872...49,965,682
Ensembl chr12:49,961,872...49,965,682

G

BCL2 associated X, apoptosis regulator

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA]

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCAR1 scaffold protein, Cas family member

multiple interactions

Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]

NCBI chr16:75,228,181...75,268,007
Ensembl chr16:75,228,181...75,268,053

G

butyrylcholinesterase

multiple interactions

[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX

PMID:17963125 PMID:22981459

NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462

G

bradykinin receptor B2

multiple interactions

BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine]

NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166

G

bone morphogenetic protein 6

multiple interactions

Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA]

NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728

G

calcium voltage-gated channel subunit alpha1 E

multiple interactions

Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]

NCBI chr 1:181,317,699...181,808,084
Ensembl chr 1:181,317,690...181,813,262

G

calcitonin related polypeptide alpha

affects activity

Atropine affects the activity of CALCA protein

PMID:7906887 PMID:10075105

NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354

G

caspase 3

increases expression

Atropine results in increased expression of CASP3 mRNA

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

C-C motif chemokine ligand 5

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein]

NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793

G

cyclin A1

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA
Atropine results in increased expression of CCNA1 mRNA

NCBI chr13:36,431,517...36,442,870
Ensembl chr13:36,431,520...36,442,870

G

cyclin D3

multiple interactions

[Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA

NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357

G

cyclin E1

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA
Atropine results in increased expression of CCNE1 mRNA

NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312

G

cyclin E2

increases expression
multiple interactions

Atropine results in increased expression of CCNE2 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA

NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678

G

CD40 molecule

multiple interactions

Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein]

NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863

G

cell division cycle 20

increases expression
multiple interactions

Atropine results in increased expression of CDC20 mRNA
[Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA

NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203

G

cell division cycle 6

multiple interactions

[Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA

NCBI chr17:40,287,879...40,304,657
Ensembl chr17:40,287,879...40,304,657

G

cyclin dependent kinase 1

increases expression
multiple interactions

Atropine results in increased expression of CDK1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

carboxylesterase 1

multiple interactions

Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]

NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337

G

cholinergic receptor muscarinic 1

multiple interactions
decreases activity

Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Atropine results in decreased activity of CHRM1 protein
Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]

PMID:16439611 PMID:18316702 PMID:31830555

NCBI chr11:62,908,679...62,921,878
Ensembl chr11:62,908,679...62,921,807

G

cholinergic receptor muscarinic 2

multiple interactions

Atropine binds to and results in decreased activity of CHRM2 protein

NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255

G

cholinergic receptor muscarinic 3

multiple interactions
decreases activity

Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]
Atropine results in decreased activity of CHRM3 protein

PMID:15140916 PMID:20708676 PMID:31830555

NCBI chr 1:239,386,568...239,915,450
Ensembl chr 1:239,386,565...239,915,452

G

cholinergic receptor muscarinic 4

affects binding
multiple interactions

Atropine binds to CHRM4 protein
[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein]

NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,383,789...46,391,776

G

cholinergic receptor muscarinic 5

multiple interactions

Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein]

NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions
affects binding

Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]

PMID:15733544 PMID:21791372

NCBI chr20:63,343,223...63,361,349
Ensembl chr20:63,343,223...63,378,401

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]

PMID:15733544 PMID:21791372

NCBI chr 1:154,567,778...154,580,013
Ensembl chr 1:154,567,778...154,580,013

G

cAMP responsive element binding protein 1

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein]

NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988

G

corticotropin releasing hormone

multiple interactions

[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein
Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]

PMID:12039681 PMID:12906840

NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464

G

catenin beta 1

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein]

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

G

C-X-C motif chemokine ligand 1

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein]

NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308

G

dishevelled segment polarity protein 2

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein]

NCBI chr17:7,225,342...7,234,517
Ensembl chr17:7,225,342...7,234,517

G

endothelin 1

multiple interactions

EDN1 protein results in decreased activity of [Atropine co-treated with Histamine]

NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194

G

epidermal growth factor receptor

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein]

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

early growth response 1

multiple interactions

Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

G

early growth response 2

multiple interactions

Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]

NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,819,167

G

ezrin

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of EZR protein]

NCBI chr 6:158,765,748...158,819,368
Ensembl chr 6:158,765,741...158,819,368

G

coagulation factor II, thrombin

multiple interactions

[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein

NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506

G

coagulation factor II thrombin receptor

multiple interactions

[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein

NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]
Atropine results in increased expression of FOS protein

PMID:7968354 PMID:8281324 PMID:21787676 PMID:21971501

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

G

ghrelin and obestatin prepropeptide

multiple interactions

Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein]

NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947

G

glycine receptor alpha 1

multiple interactions

Atropine binds to and results in decreased activity of GLRA1 protein

NCBI chr 5:151,822,513...151,924,851
Ensembl chr 5:151,822,513...151,924,851

G

glutamate metabotropic receptor 4

multiple interactions

Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr 6:34,018,643...34,155,622
Ensembl chr 6:34,018,643...34,155,622

G

intercellular adhesion molecule 1

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein]

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

interleukin 1 beta

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions

[Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein]

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]

NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315

G

potassium inwardly rectifying channel subfamily J member 3

multiple interactions

Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr 2:154,698,695...154,858,354
Ensembl chr 2:154,697,855...154,858,354

G

KIT proto-oncogene, receptor tyrosine kinase

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of KIT protein]

NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783

G

lactotransferrin

multiple interactions

Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein]

NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234

G

mitogen-activated protein kinase 1

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 14

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein]

NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236

G

mitogen-activated protein kinase 3

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein]

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

minichromosome maintenance complex component 4

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA
Atropine results in increased expression of MCM4 mRNA

NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160

G

minichromosome maintenance complex component 6

increases expression
multiple interactions

Atropine results in increased expression of MCM6 mRNA
[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA

NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443

G

neurofilament heavy chain

affects expression

Atropine affects the expression of NEFH mRNA

NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390

G

NLR family pyrin domain containing 3

increases expression

Atropine results in increased expression of NLRP3 mRNA

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108

G

nitric oxide synthase 2

multiple interactions

Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]

PMID:15610444 PMID:16944022

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

notch receptor 4

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein]

NCBI chr 6:32,194,843...32,224,067
Ensembl chr 6:32,194,843...32,224,067

G

natriuretic peptide A

affects activity

Atropine affects the activity of NPPA protein modified form

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

G

opioid related nociceptin receptor 1

multiple interactions

Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]

NCBI chr20:64,080,082...64,100,643
Ensembl chr20:64,080,082...64,100,643

G

proliferating cell nuclear antigen

multiple interactions

Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA]

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

G

prepronociceptin

multiple interactions

Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]

NCBI chr 8:28,316,988...28,343,351
Ensembl chr 8:28,316,986...28,343,355

G

proopiomelanocortin

multiple interactions

Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein]

NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903

G

peroxisome proliferator activated receptor alpha

multiple interactions

[Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]

NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA]

PMID:15104355 PMID:15610444 PMID:16259740 PMID:16804302

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

protein tyrosine kinase 2

multiple interactions

Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]]

NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216

G

paxillin

multiple interactions

Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]

NCBI chr12:120,210,447...120,265,730
Ensembl chr12:120,210,439...120,265,771

G

Rac family small GTPase 3

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein]

NCBI chr17:82,031,678...82,034,204
Ensembl chr17:82,031,678...82,034,204

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein]

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

ras homolog family member A

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein]

NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998

G

solute carrier family 22 member 1

multiple interactions

Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

PMID:16263091 PMID:21641380

NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718

G

solute carrier family 22 member 2

multiple interactions

Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]

PMID:16263091 PMID:21599003 PMID:23770354

NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638

G

solute carrier family 22 member 3

multiple interactions
increases uptake

Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
SLC22A3 protein results in increased uptake of Atropine

NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577

G

solute carrier family 22 member 4

multiple interactions

Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]

NCBI chr 5:132,294,394...132,344,190
Ensembl chr 5:132,294,394...132,344,190

G

solute carrier family 47 member 1

multiple interactions

Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034

G

solute carrier family 47 member 2

multiple interactions

Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr17:19,678,317...19,718,979
Ensembl chr17:19,678,288...19,718,979

G

secretory leukocyte peptidase inhibitor

increases expression

Atropine results in increased expression of SLPI mRNA

NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564

G

suppressor of cytokine signaling 3

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA]

NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077

G

sialophorin

increases response to substance

SPN protein results in increased susceptibility to Atropine

NCBI chr16:29,662,963...29,670,876
Ensembl chr16:29,662,979...29,670,876

G

tyrosine aminotransferase

multiple interactions

[Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein]

NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092

G

transforming growth factor beta 1

multiple interactions

Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

tumor necrosis factor

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein]

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

tumor protein p53

multiple interactions

Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein]

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

trio Rho guanine nucleotide exchange factor

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein]

NCBI chr 5:14,143,342...14,510,204
Ensembl chr 5:14,143,342...14,532,128

G

transient receptor potential cation channel subfamily A member 1

decreases response to substance

TRPA1 gene mutant form results in decreased susceptibility to Atropine

NCBI chr 8:72,021,250...72,090,010
Ensembl chr 8:72,019,917...72,075,584

G

thyroid stimulating hormone subunit beta

multiple interactions

[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein]

NCBI chr 1:115,029,826...115,034,309
Ensembl chr 1:115,029,826...115,034,302

G

translocator protein

multiple interactions

[Ketamine co-treated with Midazolam co-treated with Valproic Acid] inhibits the reaction [[Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein]; [Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein

NCBI chr22:43,151,559...43,163,242
Ensembl chr22:43,151,547...43,163,242

G

vascular cell adhesion molecule 1

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA]

NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045

tropisetron

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases expression
multiple interactions

Tropisetron results in increased expression of CASP3 protein modified form
Tropisetron inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]
Paclitaxel inhibits the reaction [Tropisetron results in increased expression of CASP3 protein modified form]

PMID:34654991 PMID:36504472

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

C-C motif chemokine ligand 3

multiple interactions
decreases expression

chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CCL3 protein]

NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169

G

cystatin C

multiple interactions

Tropisetron inhibits the reaction [Streptozocin results in increased expression of CST3 protein]

NCBI chr20:23,626,706...23,637,955
Ensembl chr20:23,626,706...23,638,473

G

C-X-C motif chemokine ligand 1

multiple interactions
decreases expression

chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein]

NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308

G

C-X-C motif chemokine ligand 2

multiple interactions
decreases expression

chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein]

NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196

G

heme oxygenase 1

increases expression
multiple interactions

tropisetron results in increased expression of HMOX1 protein
SB 203580 inhibits the reaction [tropisetron results in increased expression of HMOX1 protein]

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

intercellular adhesion molecule 1

multiple interactions
decreases expression

chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein]

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

interleukin 1 beta

multiple interactions

tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Tropisetron inhibits the reaction [Streptozocin results in increased expression of IL1B protein]

PMID:24374478 PMID:36504472

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 2

multiple interactions

tropisetron inhibits the reaction [Vincristine results in increased expression of IL2 protein]

NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725

G

interleukin 6

multiple interactions
decreases expression

chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of IL6 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

interleukin 1 receptor associated kinase 1

multiple interactions

Tropisetron inhibits the reaction [Streptozocin results in increased expression of IRAK1 protein]

NCBI chr X:154,010,507...154,019,902
Ensembl chr X:154,010,506...154,019,902

G

microRNA 146a

multiple interactions

Tropisetron inhibits the reaction [Streptozocin results in increased expression of MIR146A mRNA]

NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450

G

matrix metallopeptidase 2

multiple interactions

Tropisetron inhibits the reaction [Streptozocin results in decreased expression of MMP2 mRNA]

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 9

multiple interactions

Tropisetron inhibits the reaction [Streptozocin results in decreased expression of MMP9 mRNA]

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

myeloperoxidase

multiple interactions
decreases activity

chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased activity of MPO protein]; SB 203580 inhibits the reaction [tropisetron results in decreased activity of MPO protein]
tropisetron inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein]

PMID:23285267 PMID:25837923

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[Paclitaxel co-treated with Tropisetron] results in decreased expression of RELA protein
Tropisetron inhibits the reaction [Streptozocin results in increased expression of RELA protein]

PMID:34654991 PMID:36504472

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

solute carrier family 22 member 2

multiple interactions

tropisetron inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638

G

transforming growth factor beta 1

multiple interactions

Tropisetron inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

toll like receptor 4

multiple interactions

Tropisetron inhibits the reaction [Streptozocin results in increased expression of TLR4 protein]

NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735

G

tumor necrosis factor

multiple interactions
decreases expression

chromium mesoporphyrin inhibits the reaction [Tropisetron results in decreased expression of TNF protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Tropisetron inhibits the reaction [Vincristine results in increased expression of TNF protein]
tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
tropisetron results in decreased expression of TNF protein

PMID:23285267 PMID:24374478 PMID:36504472

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

tumor protein p53

multiple interactions

Tropisetron inhibits the reaction [Streptozocin results in increased expression of TP53 protein]

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

TNF receptor associated factor 6

multiple interactions

Tropisetron inhibits the reaction [Streptozocin results in increased expression of TRAF6 protein]

NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26041
role	25957
biological role	25936
biochemical role	25170
metabolite	25100
alkaloid	8055
tropane alkaloid	1569
(2R,3S)-3-Hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid	0
(2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester	0
(2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester	0
(2S)-3-hydroxy-2-phenylpropanoic acid [(5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester	0
(6R)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-one	0
1-(1-adamantyl)-3-[8-[[1-(2-furanylmethyl)-5-tetrazolyl]methyl]-8-azabicyclo[3.2.1]octan-3-yl]urea	0
18-demethylgardfloramine	0
18-demethylgardneramine	0
19(E)-11-Methoxy-9,18-didemethoxygardneramine	0
19(E)-18-Demethoxygardfloramine-N(4)-oxide	0
19(E)-18-demethoxygardfloramine	0
19(E)-18-demethoxygardneramine	0
19(E)-9,18-Didemethoxygardneramine	0
2-(4-bromophenyl)propanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester	0
2-hydroxy-2-phenylacetic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester	0
2-hydroxy-2-phenylacetic acid [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester	0
2-hydroxy-2-phenylacetic acid [(5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester	0
3,6-Ditigloyloxytropan-7-ol	0
3-hydroxy-2-phenylpropanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester	0
3-hydroxy-2-phenylpropanoic acid (8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl) ester	0
3-hydroxy-2-phenylpropanoic acid [(1R,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester	0
3-hydroxy-2-phenylpropanoic acid [(5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester	0
3-hydroxy-2-phenylpropanoic acid [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester	0
3alpha-Tigloyloxytropane N-oxide	0
3beta,6beta-Dihydroxynortropane	0
4,4-Difluoro-N-[(1S)-3-[(1R,5S)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboximidic acid	0
4,4-difluoro-N-[(1S)-3-[3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]-1-cyclohexanecarboxamide	0
4-Hydroxyphenyl Maraviroc	0
4-Oxohomoanatoxin-A	0
4R-Hydroxyhomoanatoxin-A	0
4S-Hydroxyhomoanatoxin-A	0
9-Demethoxy-18-demethylgardneramine	0
Acetylpseudotropine	0
Anatoxin a	1
Brugine	0
Calistegin B2	0
Calystegine A6	0
Calystegine A7	0
Calystegine B5	0
Calystegine C1	0
Gardfloramine-N(4)-oxide	0
Homoanatoxin-a	0
Knightinol	0
L-3alpha,6beta-Ditigloyloxytropane	0
Littorine	0
Meteloidine	0
Methyl (2R)-8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate	0
N-Methylcalystegine B2	0
N-Methylcalystegine C1	0
Nor-psi-tropine	0
O-hydroxy(phenyl)phosphinoyl ecgonine methyl ester	0
Physoperuvine	0
Pseudoecgonine	0
Schizanthine N	0
Schizanthine O	0
Schizanthine P	0
Scopoline	0
Tigloidine	0
Valeroidine	0
[(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate	0
[(1S,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate	0
[(6R,7S)-6,7-Dihydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (E)-2-methylbut-2-enoate	0
atropine oxyde	0
butylscopolamine +	1
cocaine	1443
cocaine(1+) +	0
ecgonine +	2
ecgonine benzoate	1
ecgonine methyl ester +	1
ecgonone methyl ester	0
gardfloramine	0
gardneramine	0
gardneramine-N(4)-oxide	0
ipratropium +	7
itasetron	0
methylatropine	0
pseudotropine +	0
scopolamine +	128
tematropium methylsulfate	0
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate +	95
tropane +	0
tropanyl 3,5-dimethylbenzoate	0
tropine +	108
tropinone	0
Path 2
Term	Annotations
CHEBI ontology	26041
subatomic particle	26016
composite particle	26016
hadron	26016
baryon	26016
nucleon	26016
atomic nucleus	26016
atom	26016
main group element atom	25841
p-block element atom	25841
carbon group element atom	25441
carbon atom	25399
organic molecular entity	25399
organic molecule	25228
organic cyclic compound	24281
organic heterocyclic compound	22324
organic heteropolycyclic compound	21329
organic heterobicyclic compound	18582
azabicycloalkane	3509
tropane alkaloid	1569
(2R,3S)-3-Hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid	0
(2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester	0
(2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester	0
(2S)-3-hydroxy-2-phenylpropanoic acid [(5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester	0
(6R)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-one	0
1-(1-adamantyl)-3-[8-[[1-(2-furanylmethyl)-5-tetrazolyl]methyl]-8-azabicyclo[3.2.1]octan-3-yl]urea	0
18-demethylgardfloramine	0
18-demethylgardneramine	0
19(E)-11-Methoxy-9,18-didemethoxygardneramine	0
19(E)-18-Demethoxygardfloramine-N(4)-oxide	0
19(E)-18-demethoxygardfloramine	0
19(E)-18-demethoxygardneramine	0
19(E)-9,18-Didemethoxygardneramine	0
2-(4-bromophenyl)propanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester	0
2-hydroxy-2-phenylacetic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester	0
2-hydroxy-2-phenylacetic acid [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester	0
2-hydroxy-2-phenylacetic acid [(5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester	0
3,6-Ditigloyloxytropan-7-ol	0
3-hydroxy-2-phenylpropanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester	0
3-hydroxy-2-phenylpropanoic acid (8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl) ester	0
3-hydroxy-2-phenylpropanoic acid [(1R,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester	0
3-hydroxy-2-phenylpropanoic acid [(5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester	0
3-hydroxy-2-phenylpropanoic acid [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester	0
3alpha-Tigloyloxytropane N-oxide	0
3beta,6beta-Dihydroxynortropane	0
4,4-Difluoro-N-[(1S)-3-[(1R,5S)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboximidic acid	0
4,4-difluoro-N-[(1S)-3-[3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]-1-cyclohexanecarboxamide	0
4-Hydroxyphenyl Maraviroc	0
4-Oxohomoanatoxin-A	0
4R-Hydroxyhomoanatoxin-A	0
4S-Hydroxyhomoanatoxin-A	0
9-Demethoxy-18-demethylgardneramine	0
Acetylpseudotropine	0
Anatoxin a	1
Brugine	0
Calistegin B2	0
Calystegine A6	0
Calystegine A7	0
Calystegine B5	0
Calystegine C1	0
Gardfloramine-N(4)-oxide	0
Homoanatoxin-a	0
Knightinol	0
L-3alpha,6beta-Ditigloyloxytropane	0
Littorine	0
Meteloidine	0
Methyl (2R)-8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate	0
N-Methylcalystegine B2	0
N-Methylcalystegine C1	0
Nor-psi-tropine	0
O-hydroxy(phenyl)phosphinoyl ecgonine methyl ester	0
Physoperuvine	0
Pseudoecgonine	0
Schizanthine N	0
Schizanthine O	0
Schizanthine P	0
Scopoline	0
Tigloidine	0
Valeroidine	0
[(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate	0
[(1S,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate	0
[(6R,7S)-6,7-Dihydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (E)-2-methylbut-2-enoate	0
atropine oxyde	0
butylscopolamine +	1
cocaine	1443
cocaine(1+) +	0
ecgonine +	2
ecgonine benzoate	1
ecgonine methyl ester +	1
ecgonone methyl ester	0
gardfloramine	0
gardneramine	0
gardneramine-N(4)-oxide	0
ipratropium +	7
itasetron	0
methylatropine	0
pseudotropine +	0
scopolamine +	128
tematropium methylsulfate	0
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate +	95
tropane +	0
tropanyl 3,5-dimethylbenzoate	0
tropine +	108
tropinone	0

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