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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1-ribosylimidazole
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Accession:CHEBI:37293 term browser browse the term
Synonyms:related_synonym: 1-ribosylimidazoles

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acadesine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 decreases expression ISO acadesine decreases expression of Abcb11 mRNA in primary hepatocytes RGD PMID:27090119 RGD:15090804 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 decreases expression ISO acadesine decreases expression of Abcc2 mRNA in primary hepatocytes RGD PMID:27090119 RGD:15090804 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740 		JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha increases phosphorylation ISO acadesine results in increased phosphorylation of ACACA protein CTD PMID:22496244 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651 		JBrowse link
G Acads acyl-Coenzyme A dehydrogenase, short chain multiple interactions ISO acadesine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of ACADS mRNA]; acadesine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of and results in decreased activity of ACADS protein] CTD PMID:26989860 NCBI chr 5:115,110,299...115,119,346
Ensembl chr 5:115,110,299...115,119,346 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
decreases phosphorylation		 EXP acadesine results in increased phosphorylation of AKT1 protein
acadesine results in decreased phosphorylation of AKT1 protein		 CTD PMID:22137261 PMID:25603053 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884 		JBrowse link
G Apln apelin multiple interactions EXP acadesine inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA]; acadesine inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] CTD PMID:21461750 NCBI chr  X:48,025,146...48,034,853
Ensembl chr  X:48,025,146...48,034,853 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO acadesine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein] CTD PMID:26989860 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO acadesine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]
acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]		 CTD PMID:26989860 PMID:33002460 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions EXP acadesine promotes the reaction [Zearalenone results in increased expression of BECN1 protein] CTD PMID:31982503 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO
EXP		 acadesine promotes the reaction [Isoniazid results in increased cleavage of CASP3 protein]
acadesine results in increased cleavage of CASP3 protein
acadesine inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]		 CTD PMID:22137261 PMID:25603053 PMID:26989860 PMID:28556920 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp9 caspase 9 increases cleavage EXP acadesine results in increased cleavage of CASP9 protein CTD PMID:22137261 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein] CTD PMID:33002460 NCBI chr 8:121,590,438...121,598,760
Ensembl chr 8:121,590,361...121,598,760 		JBrowse link
G Mef2c myocyte enhancer factor 2C decreases expression ISO acadesine results in decreased expression of MEF2C mRNA CTD PMID:15864539 NCBI chr13:83,504,017...83,667,079
Ensembl chr13:83,504,034...83,667,080 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP
ISO		 acadesine promotes the reaction [Zearalenone results in decreased phosphorylation of MTOR protein]
acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]		 CTD PMID:31982503 PMID:33002460 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO acadesine decreases expression of Nr1h4 mRNA and protein in primary hepatocytes RGD PMID:27090119 RGD:15090804 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
increases expression		 ISO acadesine inhibits the reaction [Isoniazid results in decreased expression of NRF1 protein]
acadesine results in increased expression of NRF1 protein		 CTD PMID:28556920 NCBI chr 6:30,047,985...30,153,458
Ensembl chr 6:30,047,988...30,153,458 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein] CTD PMID:33002460 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO acadesine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARA mRNA]; acadesine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARA protein] CTD PMID:26989860 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression
multiple interactions		 ISO acadesine results in increased expression of PPARGC1A protein
Dietary Fats promotes the reaction [acadesine results in increased expression of PPARGC1A mRNA]
acadesine inhibits the reaction [Isoniazid results in decreased expression of PPARGC1A protein]		 CTD PMID:22496244 PMID:28556920 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit increases phosphorylation ISO acadesine increases phosphorylation of Prkaa1 in primary hepatocytes
acadesine results in increased phosphorylation of PRKAA1 protein		 CTD PMID:22815988, PMID:27090119 RGD:15090804 NCBI chr15:5,143,861...5,181,899
Ensembl chr15:5,143,861...5,181,899 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO acadesine inhibits the reaction [[Fluorouracil results in increased expression of PTGS2 protein] which results in increased abundance of and results in increased secretion of Dinoprostone]; acadesine inhibits the reaction [Fluorouracil results in increased expression of PTGS2 protein] CTD PMID:15896711 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions EXP acadesine promotes the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:31982503 NCBI chr11:86,498,869...86,544,885
Ensembl chr11:86,498,871...86,544,805 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression		 ISO acadesine inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein]
acadesine results in increased expression of SIRT1 protein		 CTD PMID:28556920 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704 		JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 decreases expression ISO acadesine decreases expression of Slc10a1 mRNA in primary hepatocytes RGD PMID:27090119 RGD:15090804 NCBI chr12:80,953,185...80,968,705
Ensembl chr12:80,953,183...80,968,705 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 increases expression ISO acadesine results in increased expression of SLC2A1 mRNA CTD PMID:15864539 NCBI chr 4:119,108,745...119,137,330
Ensembl chr 4:119,108,711...119,137,983 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression ISO acadesine decreases expression of Slco1a4 mRNA in primary hepatocytes RGD PMID:27090119 RGD:15090804 NCBI chr 6:141,805,438...141,856,284
Ensembl chr 6:141,805,440...141,856,199 		JBrowse link
G Ulk1 unc-51 like kinase 1 multiple interactions ISO acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein] CTD PMID:33002460 NCBI chr 5:110,784,489...110,810,120
Ensembl chr 5:110,784,488...110,810,097 		JBrowse link
AICA ribonucleotide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 decreases expression ISO AICA ribonucleotide results in decreased expression of ABCB11 mRNA CTD PMID:27090119 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 decreases expression ISO AICA ribonucleotide results in decreased expression of ABCC2 mRNA CTD PMID:27090119 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740 		JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha increases phosphorylation
multiple interactions
increases expression		 ISO
EXP		 AICA ribonucleotide results in increased phosphorylation of ACACA protein
AICA ribonucleotide inhibits the reaction [fipronil results in increased expression of and results in decreased phosphorylation of ACACA protein]; AICA ribonucleotide results in decreased expression of and results in increased phosphorylation of ACACA protein
AICA ribonucleotide results in increased expression of ACACA protein modified form		 CTD PMID:15297373 PMID:16020477 PMID:16873680 PMID:20080969 PMID:25743752 PMID:27103584 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651 		JBrowse link
G Acacb acetyl-Coenzyme A carboxylase beta increases phosphorylation ISO AICA ribonucleotide results in increased phosphorylation of ACACB protein CTD PMID:16873680 NCBI chr 5:114,146,321...114,250,761
Ensembl chr 5:114,146,535...114,250,761 		JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain multiple interactions
increases expression		 ISO AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of ACADM mRNA]
AICA ribonucleotide results in increased expression of ACADM mRNA; AICA ribonucleotide results in increased expression of ACADM protein		 CTD PMID:19699196 PMID:25743752 NCBI chr 3:153,922,353...153,944,643
Ensembl chr 3:153,922,357...153,944,632 		JBrowse link
G Acta2 actin, alpha 2, smooth muscle, aorta multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:27688165 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
multiple interactions		 EXP
ISO		 AICA ribonucleotide results in increased expression of ADIPOQ protein
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in decreased expression of ADIPOQ mRNA]		 CTD PMID:20980258 PMID:25108154 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions EXP AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in decreased oxidation of Fatty Acids]; AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in increased phosphorylation of EIF4EBP1 protein]; AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in increased susceptibility to Glucose deficiency]; PRKAA2 protein affects the reaction [AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form affects the susceptibility to Glucose deficiency]] CTD PMID:15806154 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884 		JBrowse link
G App amyloid beta (A4) precursor protein decreases expression ISO AICA ribonucleotide results in decreased expression of APP protein modified form CTD PMID:20080969 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766 		JBrowse link
G Arg1 arginase, liver multiple interactions ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 mRNA] CTD PMID:25108154 NCBI chr10:24,915,207...24,927,470
Ensembl chr10:24,915,221...24,927,484 		JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Ethanol results in decreased expression of ATG5 protein] CTD PMID:24582693 NCBI chr10:44,268,322...44,364,299
Ensembl chr10:44,268,358...44,364,291 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
increases expression		 ISO AICA ribonucleotide promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]
AICA ribonucleotide results in increased expression of BECN1 protein		 CTD PMID:28041982 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO AICA ribonucleotide results in increased activity of CASP3 protein
AICA ribonucleotide inhibits the reaction [sunitinib results in increased cleavage of CASP3 protein]		 CTD PMID:16469385 PMID:21906609 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO AICA ribonucleotide inhibits the reaction [sunitinib results in increased cleavage of CASP7 protein] CTD PMID:21906609 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344 		JBrowse link
G Casp9 caspase 9 increases activity ISO AICA ribonucleotide results in increased activity of CASP9 protein CTD PMID:16469385 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Cat catalase multiple interactions
increases expression		 ISO AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of CAT mRNA]
AICA ribonucleotide results in increased expression of CAT mRNA; AICA ribonucleotide results in increased expression of CAT protein		 CTD PMID:25065674 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160 		JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions
decreases expression		 ISO
EXP		 AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of CCL2 mRNA]
AICA ribonucleotide results in decreased expression of CCL2 mRNA
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in decreased expression of CCL2 mRNA]		 CTD PMID:24465016 PMID:25108154 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453 		JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA] CTD PMID:21745629 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355 		JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression		 ISO AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR]
AICA ribonucleotide results in decreased expression of CCNA2 mRNA; AICA ribonucleotide results in decreased expression of CCNA2 protein		 CTD PMID:12730239 NCBI chr 3:36,564,865...36,573,038
Ensembl chr 3:36,564,865...36,572,150 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression		 ISO AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR]
AICA ribonucleotide results in decreased expression of CCNB1 mRNA; AICA ribonucleotide results in decreased expression of CCNB1 protein		 CTD PMID:12730239 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO AICA ribonucleotide results in increased expression of and affects the localization of CD36 protein CTD PMID:28038998 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801 		JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha decreases expression
multiple interactions		 EXP AICA ribonucleotide results in decreased expression of CEBPA protein
AICA ribonucleotide inhibits the reaction [fipronil results in increased expression of CEBPA protein]		 CTD PMID:27103584 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928 		JBrowse link
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta increases phosphorylation ISO AICA ribonucleotide results in increased phosphorylation of CEBPB protein CTD PMID:28038998 NCBI chr 2:167,688,915...167,690,432
Ensembl chr 2:167,688,915...167,690,418 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO AICA ribonucleotide inhibits the reaction [Colforsin results in increased activity of CFTR protein] CTD PMID:12519745 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768 		JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] CTD PMID:27688165 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver increases expression
multiple interactions		 ISO
EXP		 AICA ribonucleotide results in increased expression of CPT1A mRNA; AICA ribonucleotide results in increased expression of CPT1A protein
dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of CPT1A mRNA]		 CTD PMID:24465016 PMID:25743752 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1b, muscle multiple interactions ISO AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B protein] CTD PMID:19699196 NCBI chr15:89,416,405...89,425,862
Ensembl chr15:89,416,405...89,425,863 		JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions
increases expression		 EXP [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 mRNA; [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 protein; AICA ribonucleotide inhibits the reaction [[HDAC5 protein binds to MEF2 protein] which binds to CTNNB1 promoter]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 mRNA]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 protein]
AICA ribonucleotide results in increased expression of CTNNB1 mRNA; AICA ribonucleotide results in increased expression of CTNNB1 protein		 CTD PMID:21454484 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507 		JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of CXCL8 mRNA] CTD PMID:21745629 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067 		JBrowse link
G Cyba cytochrome b-245, alpha polypeptide multiple interactions ISO AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein] CTD PMID:21195169 NCBI chr 8:122,424,771...122,432,940
Ensembl chr 8:122,424,776...122,432,930 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein] CTD PMID:21195169 NCBI chr  X:9,435,252...9,487,766
Ensembl chr  X:9,435,252...9,487,771 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions ISO AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]; PRKAA2 protein promotes the reaction [AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]] CTD PMID:22815988 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO AICA ribonucleotide inhibits the reaction [EGFR protein results in increased import of Deoxyglucose] CTD PMID:19625624 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha decreases phosphorylation ISO AICA ribonucleotide results in decreased phosphorylation of EIF2S1 protein CTD PMID:22898769 NCBI chr12:78,862,072...78,887,010
Ensembl chr12:78,861,819...78,887,010 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases phosphorylation		 EXP
ISO		 AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in increased phosphorylation of EIF4EBP1 protein]
AICA ribonucleotide results in decreased phosphorylation of EIF4EBP1 protein
AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein]		 CTD PMID:15806154 PMID:21195169 PMID:28041982 NCBI chr 8:27,260,327...27,275,656
Ensembl chr 8:27,260,329...27,276,674 		JBrowse link
G Elavl1 ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) multiple interactions
decreases localization		 ISO AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR]; AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR]
AICA ribonucleotide results in decreased localization of ELAVL1 protein		 CTD PMID:12730239 NCBI chr 8:4,284,781...4,325,140
Ensembl chr 8:4,285,382...4,325,413 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions
increases expression
increases phosphorylation
increases activity		 ISO AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of CAT mRNA]; AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of SOD2 mRNA]
AICA ribonucleotide results in increased expression of FOXO1 protein
AICA ribonucleotide results in increased phosphorylation of FOXO1 protein
AICA ribonucleotide results in increased activity of FOXO1 protein		 CTD PMID:25065674 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221 		JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions ISO AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK1 protein]; AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK3 protein]; AICA ribonucleotide inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein] CTD PMID:16020477 NCBI chr 2:107,055,986...107,059,651
Ensembl chr 2:107,056,140...107,059,656 		JBrowse link
G G6pc glucose-6-phosphatase, catalytic decreases expression ISO AICA ribonucleotide results in decreased expression of G6PC1 mRNA CTD PMID:19664596 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903 		JBrowse link
G Gpr68 G protein-coupled receptor 68 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TNF protein promotes the reaction [Oxygen deficiency results in increased expression of GPR68 mRNA]]; AICA ribonucleotide inhibits the reaction [TNF protein results in increased expression of GPR68 mRNA] CTD PMID:28174749 NCBI chr12:100,876,679...100,908,198
Ensembl chr12:100,876,682...100,908,198 		JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions ISO GRB2 protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] CTD PMID:11978788 NCBI chr11:115,644,045...115,708,597
Ensembl chr11:115,644,045...115,708,597 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 increases expression EXP AICA ribonucleotide results in increased expression of GSTK1 protein CTD PMID:20980258 NCBI chr 6:42,245,935...42,250,441
Ensembl chr 6:42,245,935...42,250,447 		JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions
increases phosphorylation		 EXP [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 mRNA; [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 protein; AICA ribonucleotide inhibits the reaction [[HDAC5 protein binds to MEF2 protein] which binds to CTNNB1 promoter] CTD PMID:21454484 NCBI chr11:102,195,747...102,230,172
Ensembl chr11:102,194,432...102,230,166 		JBrowse link
G Hnf4a hepatic nuclear factor 4, alpha decreases expression EXP AICA ribonucleotide results in decreased expression of HNF4A mRNA CTD PMID:24428821 NCBI chr 2:163,506,811...163,572,907
Ensembl chr 2:163,506,808...163,572,910 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO AICA ribonucleotide results in decreased expression of HSD3B1 mRNA; AICA ribonucleotide results in decreased expression of HSD3B1 protein CTD PMID:16020477 NCBI chr 3:98,842,356...98,859,794
Ensembl chr 3:98,852,194...98,859,794 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK1 protein]; AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK3 protein]; AICA ribonucleotide inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein] CTD PMID:16020477 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 EXP AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in decreased expression of IL1B mRNA] CTD PMID:24465016 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO
EXP		 AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]
AICA ribonucleotide results in decreased expression of IL6 mRNA
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in decreased expression of IL6 mRNA]		 CTD PMID:24465016 PMID:25108154 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981 		JBrowse link
G Ins1 insulin I multiple interactions EXP AICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D1 protein]; AICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D4 protein] CTD PMID:24343960 PMID:26627467 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476 		JBrowse link
G Insr insulin receptor multiple interactions
decreases activity
decreases expression		 ISO 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]; 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]; 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein]
AICA ribonucleotide results in decreased expression of INSR mRNA; AICA ribonucleotide results in decreased expression of INSR protein		 CTD PMID:15694368 NCBI chr 8:3,150,922...3,279,649
Ensembl chr 8:3,122,061...3,279,617 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 affects response to substance EXP KCNJ11 protein affects the susceptibility to AICA ribonucleotide CTD PMID:24498880 NCBI chr 7:46,097,123...46,100,952
Ensembl chr 7:46,093,953...46,100,764 		JBrowse link
G Klf15 Kruppel-like factor 15 decreases expression EXP AICA ribonucleotide results in decreased expression of KLF15 mRNA CTD PMID:24428821 NCBI chr 6:90,461,043...90,491,803
Ensembl chr 6:90,462,576...90,475,238 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK1 protein]; AICA ribonucleotide inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]
AICA ribonucleotide results in increased phosphorylation of MAPK1 protein
AICA ribonucleotide results in decreased phosphorylation of MAPK1 protein		 CTD PMID:16020477 PMID:28038998 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK3 protein]; AICA ribonucleotide inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [AICA ribonucleotide results in increased uptake of Deoxyglucose]; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of MAPK3 protein]
AICA ribonucleotide results in increased phosphorylation of MAPK3 protein
AICA ribonucleotide results in decreased phosphorylation of MAPK3 protein		 CTD PMID:11978788 PMID:16020477 PMID:28038998 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819 		JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of MFN1 protein]; AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN1 protein] CTD PMID:27792760 NCBI chr 3:32,529,443...32,579,225
Ensembl chr 3:32,529,465...32,579,239 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of MFN2 protein]; AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN2 protein] CTD PMID:27792760 NCBI chr 4:147,873,586...147,904,909
Ensembl chr 4:147,873,599...147,904,704 		JBrowse link
G Mgl2 macrophage galactose N-acetyl-galactosamine specific lectin 2 increases expression
multiple interactions		 EXP AICA ribonucleotide results in increased expression of MGL2 mRNA
dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of MGL2 mRNA]		 CTD PMID:24465016 NCBI chr11:70,130,125...70,137,542
Ensembl chr11:70,130,329...70,137,550 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein] CTD PMID:27688165 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO AICA ribonucleotide results in decreased activity of MMP2 protein CTD PMID:20590612 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity ISO AICA ribonucleotide results in decreased activity of MMP9 protein CTD PMID:20590612 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases activity
decreases phosphorylation
multiple interactions		 ISO
EXP		 AICA ribonucleotide results in decreased activity of MTOR protein
AICA ribonucleotide results in decreased phosphorylation of MTOR protein
AICA ribonucleotide promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]
AICA ribonucleotide promotes the reaction [Cadmium results in decreased phosphorylation of MTOR protein]		 CTD PMID:19625624 PMID:21767558 PMID:27363783 PMID:28041982 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of NCF1 protein] CTD PMID:21195169 NCBI chr 5:134,220,053...134,229,628
Ensembl chr 5:134,220,053...134,229,625 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of NCF2 protein] CTD PMID:21195169 NCBI chr 1:152,800,153...152,836,990
Ensembl chr 1:152,800,194...152,836,991 		JBrowse link
G Ncf4 neutrophil cytosolic factor 4 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of NCF4 protein] CTD PMID:21195169 NCBI chr15:78,244,164...78,262,582
Ensembl chr15:78,244,801...78,262,580 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein] CTD PMID:22025971 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO
EXP		 AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]		 CTD PMID:24465016 PMID:25108154 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]] CTD PMID:25108154 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression EXP AICA ribonucleotide results in decreased expression of NR0B2 mRNA CTD PMID:24428821 NCBI chr 4:133,553,376...133,556,686
Ensembl chr 4:133,553,376...133,556,536 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO AICA ribonucleotide results in decreased expression of NR1H4 mRNA; AICA ribonucleotide results in decreased expression of NR1H4 protein CTD PMID:27090119 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Phenobarbital results in increased localization of and results in increased activity of NR1I3 protein]; AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]; PRKAA2 protein promotes the reaction [AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]] CTD PMID:20686344 PMID:22815988 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
increases expression		 ISO dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of NRF1 mRNA] CTD PMID:20438809 NCBI chr 6:30,047,985...30,153,458
Ensembl chr 6:30,047,988...30,153,458 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions ISO AICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of OPA1 protein]; AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of OPA1 protein] CTD PMID:27792760 NCBI chr16:29,579,281...29,663,127
Ensembl chr16:29,579,334...29,654,884 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA protein] CTD PMID:19699196 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA]
AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of PPARG protein]		 CTD PMID:25108154 PMID:27688165 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions
increases expression
decreases expression		 ISO
EXP		 dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of PPARGC1A mRNA]
AICA ribonucleotide results in decreased expression of PPARGC1A mRNA
AICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; dorsomorphin promotes the reaction [AICA ribonucleotide results in decreased expression of PPARGC1A mRNA]
AICA ribonucleotide inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARGC1A protein]		 CTD PMID:20438809 PMID:23090186 PMID:24428821 PMID:25522270 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit increases phosphorylation
multiple interactions
increases expression
increases activity		 ISO
EXP		 AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein]
AICA ribonucleotide promotes the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA]; Quercetin promotes the reaction [AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 protein]
AICA ribonucleotide results in increased expression of PRKAA1 protein modified form
[AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein] which results in decreased secretion of Progesterone; AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]; AICA ribonucleotide inhibits the reaction [Sodium Chloride, Dietary results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; AICA ribonucleotide inhibits the reaction [Sodium Chloride, Dietary results in increased expression of PRKAA1 mRNA]
AICA ribonucleotide results in increased activity of PRKAA1 protein		 CTD PMID:12519745 PMID:16020477 PMID:16873680 PMID:19293639 PMID:20349193 PMID:21195169 PMID:21205922 PMID:23266269 PMID:24465016 PMID:25743752 PMID:28298333 NCBI chr15:5,143,861...5,181,899
Ensembl chr15:5,143,861...5,181,899 		JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit multiple interactions
increases phosphorylation		 ISO
EXP		 AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA2 protein; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA]
PRKAA2 protein promotes the reaction [AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]]
AICA ribonucleotide results in increased phosphorylation of PRKAA2 protein
PRKAA2 protein affects the reaction [AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form affects the susceptibility to Glucose deficiency]]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 mRNA]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 protein]		 CTD PMID:15806154 PMID:16873680 PMID:18482975 PMID:21205922 PMID:21454484 PMID:22815988 NCBI chr 4:105,029,649...105,109,898
Ensembl chr 4:105,029,874...105,109,890 		JBrowse link
G Prkcz protein kinase C, zeta multiple interactions
increases activity		 ISO 1-Butanol inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; Genistein inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; GRB2 protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] CTD PMID:11978788 NCBI chr 4:155,260,118...155,361,428
Ensembl chr 4:155,260,129...155,361,361 		JBrowse link
G Pten phosphatase and tensin homolog increases response to substance ISO PTEN protein results in increased susceptibility to AICA ribonucleotide CTD PMID:19625624 NCBI chr19:32,757,577...32,826,160
Ensembl chr19:32,757,497...32,826,160 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22025971 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227 		JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta multiple interactions ISO AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PTK2B protein; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of MAPK3 protein]; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] CTD PMID:11978788 NCBI chr14:66,153,257...66,281,100
Ensembl chr14:66,153,257...66,281,052 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of RAC1 protein] CTD PMID:21195169 NCBI chr 5:143,505,481...143,528,031
Ensembl chr 5:143,503,634...143,528,036 		JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 multiple interactions ISO RAF1 protein affects the reaction [AICA ribonucleotide results in increased uptake of Deoxyglucose] CTD PMID:11978788 NCBI chr 6:115,618,569...115,676,635
Ensembl chr 6:115,618,067...115,676,635 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP
ISO		 AICA ribonucleotide inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of RELA protein]
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]; Niacinamide inhibits the reaction [AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]		 CTD PMID:22058332 PMID:25108154 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO AICA ribonucleotide results in decreased phosphorylation of RPS6 protein CTD PMID:19625624 NCBI chr 4:86,854,099...86,857,367
Ensembl chr 4:86,854,660...86,857,412 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of RPS6KB1 protein]
AICA ribonucleotide results in decreased phosphorylation of RPS6KB1 protein		 CTD PMID:15342961 PMID:21195169 PMID:28041982 NCBI chr11:86,498,869...86,544,885
Ensembl chr11:86,498,871...86,544,805 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression		 ISO
EXP		 [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to AICA ribonucleotide
AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]
AICA ribonucleotide results in increased expression of SIRT1 protein
AICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]; AICA ribonucleotide inhibits the reaction [Streptozocin results in decreased activity of SIRT1 protein]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of SIRT1 protein]		 CTD PMID:22058332 PMID:23090186 PMID:24465016 PMID:25108154 PMID:27688165 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704 		JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 decreases expression ISO AICA ribonucleotide results in decreased expression of SLC10A1 mRNA CTD PMID:27090119 NCBI chr12:80,953,185...80,968,705
Ensembl chr12:80,953,183...80,968,705 		JBrowse link
G Slc15a1 solute carrier family 15 (oligopeptide transporter), member 1 decreases activity ISO AICA ribonucleotide results in decreased activity of SLC15A1 protein CTD PMID:22108913 NCBI chr14:121,459,621...121,505,254
Ensembl chr14:121,459,621...121,505,252 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions
increases localization		 ISO
EXP		 1-Butanol inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]; Genistein inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]; U 0126 inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]; wortmannin inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]
AICA ribonucleotide inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA]		 CTD PMID:11978788 PMID:21802492 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression ISO AICA ribonucleotide results in decreased expression of SLCO1A2 mRNA CTD PMID:27090119 NCBI chr 6:141,805,438...141,856,284
Ensembl chr 6:141,805,440...141,856,199 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
increases expression		 ISO AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of SOD2 mRNA]
AICA ribonucleotide results in increased expression of SOD2 mRNA; AICA ribonucleotide results in increased expression of SOD2 protein		 CTD PMID:25065674 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein] CTD PMID:27688165 NCBI chr10:80,115,767...80,130,679
Ensembl chr10:80,115,803...80,130,682 		JBrowse link
G Tbc1d1 TBC1 domain family, member 1 multiple interactions EXP AICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D1 protein] CTD PMID:26627467 NCBI chr 5:64,156,305...64,351,486
Ensembl chr 5:64,156,305...64,351,486 		JBrowse link
G Tbc1d4 TBC1 domain family, member 4 multiple interactions EXP AICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D4 protein] CTD PMID:24343960 PMID:26627467 NCBI chr14:101,442,360...101,609,281
Ensembl chr14:101,442,360...101,609,191 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of PPARG protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein] CTD PMID:27688165 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein] CTD PMID:27688165 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
AICA ribonucleotide inhibits the reaction [TNF protein promotes the reaction [Oxygen deficiency results in increased expression of GPR68 mRNA]]; AICA ribonucleotide inhibits the reaction [TNF protein results in increased expression of GPR68 mRNA]
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]		 CTD PMID:22025971 PMID:25108154 PMID:28174749 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a multiple interactions EXP AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A protein] CTD PMID:22025971 NCBI chr 6:125,349,723...125,362,483
Ensembl chr 6:125,349,362...125,362,484 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO [resveratrol co-treated with AICA ribonucleotide] inhibits the reaction [Glucose results in increased expression of TP53 protein] CTD PMID:26188290 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873 		JBrowse link
G Txnip thioredoxin interacting protein multiple interactions EXP AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein] CTD PMID:29031535 NCBI chr 3:96,557,957...96,561,857
Ensembl chr 3:96,557,957...96,561,883 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions ISO AICA ribonucleotide inhibits the reaction [Indican results in decreased expression of UCP2 mRNA] CTD PMID:25703824 NCBI chr 7:100,493,337...100,499,629
Ensembl chr 7:100,493,337...100,502,020 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO AICA ribonucleotide inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased secretion of VEGFA protein] CTD PMID:30724446 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369 		JBrowse link
SAICAR term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pkm pyruvate kinase, muscle multiple interactions ISO Glucose deficiency promotes the reaction [SAICAR binds to and results in increased activity of PKM protein] CTD PMID:23086999 NCBI chr 9:59,656,576...59,679,372
Ensembl chr 9:59,656,368...59,679,375 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21726
    chemical entity 21724
      atom 21712
        nonmetal atom 21605
          nitrogen atom 19263
            nitrogen molecular entity 19263
              organonitrogen compound 19033
                N-glycosyl compound 5548
                  1-glycosylimidazole 113
                    1-ribosylimidazole 113
                      (1-Ribosylimidazole)-4-acetate 0
                      1-(phosphoribosyl)imidazole + 104
                      1-ribosylimidazolecarboxamide + 113
                      5-aminoimidazole ribonucleoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21726
    subatomic particle 21712
      composite particle 21712
        hadron 21712
          baryon 21712
            nucleon 21712
              atomic nucleus 21712
                atom 21712
                  main group element atom 21629
                    p-block element atom 21629
                      carbon group element atom 21433
                        carbon atom 21333
                          organic molecular entity 21333
                            heteroorganic entity 20997
                              organochalcogen compound 20272
                                organooxygen compound 20198
                                  carbohydrates and carbohydrate derivatives 12815
                                    carbohydrate 12815
                                      carbohydrate derivative 12446
                                        glycosyl compound 11173
                                          N-glycosyl compound 5548
                                            1-glycosylimidazole 113
                                              1-ribosylimidazole 113
                                                (1-Ribosylimidazole)-4-acetate 0
                                                1-(phosphoribosyl)imidazole + 104
                                                1-ribosylimidazolecarboxamide + 113
                                                5-aminoimidazole ribonucleoside 0
paths to the root