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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1-(phosphoribosyl)imidazolecarboxamide
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Accession:CHEBI:37290 term browser browse the term
Synonyms:related_synonym: 1-(phosphoribosyl)imidazolecarboxamides

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AICA ribonucleotide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases expression ISO AICA ribonucleotide results in decreased expression of ABCB11 mRNA CTD PMID:27090119 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 decreases expression ISO AICA ribonucleotide results in decreased expression of ABCC2 mRNA CTD PMID:27090119 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ACACA acetyl-CoA carboxylase alpha increases phosphorylation
multiple interactions
increases expression		 EXP
ISO		 AICA ribonucleotide results in increased phosphorylation of ACACA protein
AICA ribonucleotide inhibits the reaction [fipronil results in increased expression of and results in decreased phosphorylation of ACACA protein]; AICA ribonucleotide results in decreased expression of and results in increased phosphorylation of ACACA protein
AICA ribonucleotide results in increased expression of ACACA protein modified form		 CTD PMID:15297373 PMID:16020477 PMID:16873680 PMID:20080969 PMID:25743752 PMID:27103584 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G ACACB acetyl-CoA carboxylase beta increases phosphorylation EXP AICA ribonucleotide results in increased phosphorylation of ACACB protein CTD PMID:16873680 NCBI chr12:109,112,666...109,268,226
Ensembl chr12:109,116,595...109,268,226 		JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain multiple interactions
increases expression		 ISO
EXP		 AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of ACADM mRNA]
AICA ribonucleotide results in increased expression of ACADM mRNA; AICA ribonucleotide results in increased expression of ACADM protein		 CTD PMID:19699196 PMID:25743752 NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,347...75,787,575
Ensembl chr 1:75,724,347...75,787,575 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions EXP AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:27688165 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing increases expression
multiple interactions		 ISO AICA ribonucleotide results in increased expression of ADIPOQ protein
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in decreased expression of ADIPOQ mRNA]		 CTD PMID:20980258 PMID:25108154 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in decreased oxidation of Fatty Acids]; AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in increased phosphorylation of EIF4EBP1 protein]; AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in increased susceptibility to Glucose deficiency]; PRKAA2 protein affects the reaction [AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form affects the susceptibility to Glucose deficiency]] CTD PMID:15806154 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G APP amyloid beta precursor protein decreases expression EXP AICA ribonucleotide results in decreased expression of APP protein modified form CTD PMID:20080969 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128 		JBrowse link
G ARG1 arginase 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 mRNA] CTD PMID:25108154 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332 		JBrowse link
G ATG5 autophagy related 5 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Ethanol results in decreased expression of ATG5 protein] CTD PMID:24582693 NCBI chr 6:106,184,476...106,325,789
Ensembl chr 6:106,045,423...106,325,791 		JBrowse link
G BECN1 beclin 1 increases expression
multiple interactions		 ISO AICA ribonucleotide results in increased expression of BECN1 protein
AICA ribonucleotide promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]		 CTD PMID:28041982 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions		 ISO
EXP		 AICA ribonucleotide results in increased activity of CASP3 protein
AICA ribonucleotide inhibits the reaction [sunitinib results in increased cleavage of CASP3 protein]		 CTD PMID:16469385 PMID:21906609 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509 		JBrowse link
G CASP7 caspase 7 multiple interactions EXP AICA ribonucleotide inhibits the reaction [sunitinib results in increased cleavage of CASP7 protein] CTD PMID:21906609 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP9 caspase 9 increases activity ISO AICA ribonucleotide results in increased activity of CASP9 protein CTD PMID:16469385 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions
increases expression		 EXP AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of CAT mRNA]
AICA ribonucleotide results in increased expression of CAT mRNA; AICA ribonucleotide results in increased expression of CAT protein		 CTD PMID:25065674 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of CCL2 mRNA]
AICA ribonucleotide results in decreased expression of CCL2 mRNA
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in decreased expression of CCL2 mRNA]		 CTD PMID:24465016 PMID:25108154 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203 		JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA] CTD PMID:21745629 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169 		JBrowse link
G CCNA2 cyclin A2 multiple interactions
decreases expression		 EXP AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR]
AICA ribonucleotide results in decreased expression of CCNA2 mRNA; AICA ribonucleotide results in decreased expression of CCNA2 protein		 CTD PMID:12730239 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCNB1 cyclin B1 multiple interactions
decreases expression		 EXP AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR]
AICA ribonucleotide results in decreased expression of CCNB1 mRNA; AICA ribonucleotide results in decreased expression of CCNB1 protein		 CTD PMID:12730239 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CD36 CD36 molecule multiple interactions EXP AICA ribonucleotide results in increased expression of and affects the localization of CD36 protein CTD PMID:28038998 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277 		JBrowse link
G CEBPA CCAAT enhancer binding protein alpha decreases expression
multiple interactions		 ISO AICA ribonucleotide results in decreased expression of CEBPA protein
AICA ribonucleotide inhibits the reaction [fipronil results in increased expression of CEBPA protein]		 CTD PMID:27103584 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534 		JBrowse link
G CEBPB CCAAT enhancer binding protein beta increases phosphorylation EXP AICA ribonucleotide results in increased phosphorylation of CEBPB protein CTD PMID:28038998 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668 		JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions ISO AICA ribonucleotide inhibits the reaction [Colforsin results in increased activity of CFTR protein] CTD PMID:12519745 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions EXP AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] CTD PMID:27688165 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression
multiple interactions		 EXP
ISO		 AICA ribonucleotide results in increased expression of CPT1A mRNA; AICA ribonucleotide results in increased expression of CPT1A protein
dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of CPT1A mRNA]		 CTD PMID:24465016 PMID:25743752 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CPT1B carnitine palmitoyltransferase 1B multiple interactions ISO AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B protein] CTD PMID:19699196 NCBI chr22:50,568,861...50,578,612
Ensembl chr22:50,568,861...50,578,465 		JBrowse link
G CTNNB1 catenin beta 1 multiple interactions
increases expression		 ISO [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 mRNA; [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 protein; AICA ribonucleotide inhibits the reaction [[HDAC5 protein binds to MEF2 protein] which binds to CTNNB1 promoter]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 mRNA]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 protein]
AICA ribonucleotide results in increased expression of CTNNB1 mRNA; AICA ribonucleotide results in increased expression of CTNNB1 protein		 CTD PMID:21454484 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of CXCL8 mRNA] CTD PMID:21745629 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716 		JBrowse link
G CYBA cytochrome b-245 alpha chain multiple interactions ISO AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein] CTD PMID:21195169 NCBI chr16:88,643,289...88,651,079
Ensembl chr16:88,643,289...88,651,054 		JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein] CTD PMID:21195169 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461 		JBrowse link
G CYP4F2 cytochrome P450 family 4 subfamily F member 2 multiple interactions
increases expression		 EXP dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA]; PRKAA1 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA] CTD PMID:21205922 NCBI chr19:15,878,023...15,898,074
Ensembl chr19:15,878,023...15,898,077 		JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP AICA ribonucleotide inhibits the reaction [EGFR protein results in increased import of Deoxyglucose] CTD PMID:19625624 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha decreases phosphorylation EXP AICA ribonucleotide results in decreased phosphorylation of EIF2S1 protein CTD PMID:22898769 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,151...67,386,516
Ensembl chr14:67,360,151...67,386,516 		JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases phosphorylation		 ISO AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in increased phosphorylation of EIF4EBP1 protein]
AICA ribonucleotide results in decreased phosphorylation of EIF4EBP1 protein
AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein]		 CTD PMID:15806154 PMID:21195169 PMID:28041982 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365 		JBrowse link
G ELAVL1 ELAV like RNA binding protein 1 multiple interactions
decreases localization		 EXP AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR]; AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR]
AICA ribonucleotide results in decreased localization of ELAVL1 protein		 CTD PMID:12730239 NCBI chr19:7,958,573...8,005,641
Ensembl chr19:7,958,573...8,005,659 		JBrowse link
G FOXO1 forkhead box O1 multiple interactions
increases expression
increases phosphorylation
increases activity		 EXP AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of CAT mRNA]; AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of SOD2 mRNA]
AICA ribonucleotide results in increased expression of FOXO1 protein
AICA ribonucleotide results in increased phosphorylation of FOXO1 protein
AICA ribonucleotide results in increased activity of FOXO1 protein		 CTD PMID:25065674 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641 		JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions ISO AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK1 protein]; AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK3 protein]; AICA ribonucleotide inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein] CTD PMID:16020477 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,016...30,235,261
Ensembl chr11:30,231,016...30,235,261 		JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO AICA ribonucleotide results in decreased expression of G6PC1 mRNA CTD PMID:19664596 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438 		JBrowse link
G GPR68 G protein-coupled receptor 68 multiple interactions EXP AICA ribonucleotide inhibits the reaction [TNF protein promotes the reaction [Oxygen deficiency results in increased expression of GPR68 mRNA]]; AICA ribonucleotide inhibits the reaction [TNF protein results in increased expression of GPR68 mRNA] CTD PMID:28174749 NCBI chr14:91,232,532...91,264,581
Ensembl chr14:91,232,532...91,253,925 		JBrowse link
G GRB2 growth factor receptor bound protein 2 multiple interactions ISO GRB2 protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] CTD PMID:11978788 NCBI chr17:75,318,076...75,405,678
Ensembl chr17:75,318,076...75,405,709 		JBrowse link
G GSTK1 glutathione S-transferase kappa 1 increases expression ISO AICA ribonucleotide results in increased expression of GSTK1 protein CTD PMID:20980258 NCBI chr 7:143,263,441...143,269,115
Ensembl chr 7:143,244,093...143,270,854 		JBrowse link
G HDAC5 histone deacetylase 5 multiple interactions
increases phosphorylation		 ISO [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 mRNA; [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 protein; AICA ribonucleotide inhibits the reaction [[HDAC5 protein binds to MEF2 protein] which binds to CTNNB1 promoter] CTD PMID:21454484 NCBI chr17:44,076,753...44,123,651
Ensembl chr17:44,076,746...44,123,702 		JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha decreases expression ISO AICA ribonucleotide results in decreased expression of HNF4A mRNA CTD PMID:24428821 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,700...44,434,596 		JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO AICA ribonucleotide results in decreased expression of HSD3B1 mRNA; AICA ribonucleotide results in decreased expression of HSD3B1 protein CTD PMID:16020477 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054 		JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK1 protein]; AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK3 protein]; AICA ribonucleotide inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein] CTD PMID:16020477 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
decreases expression		 ISO AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in decreased expression of IL1B mRNA] CTD PMID:24465016 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions
decreases expression		 ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]
AICA ribonucleotide results in decreased expression of IL6 mRNA
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in decreased expression of IL6 mRNA]		 CTD PMID:24465016 PMID:25108154 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INSR insulin receptor multiple interactions
decreases activity
decreases expression		 EXP 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]; 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]; 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein]
AICA ribonucleotide results in decreased expression of INSR mRNA; AICA ribonucleotide results in decreased expression of INSR protein		 CTD PMID:15694368 NCBI chr19:7,112,257...7,294,414
Ensembl chr19:7,112,255...7,294,414 		JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 affects response to substance ISO KCNJ11 protein affects the susceptibility to AICA ribonucleotide CTD PMID:24498880 NCBI chr11:17,385,246...17,389,346
Ensembl chr11:17,385,859...17,389,331
Ensembl chr11:17,385,859...17,389,331 		JBrowse link
G KLF15 Kruppel like factor 15 decreases expression ISO AICA ribonucleotide results in decreased expression of KLF15 mRNA CTD PMID:24428821 NCBI chr 3:126,288,121...126,357,408
Ensembl chr 3:126,342,635...126,357,408 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO
EXP		 AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK1 protein]; AICA ribonucleotide inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]
AICA ribonucleotide results in increased phosphorylation of MAPK1 protein
AICA ribonucleotide results in decreased phosphorylation of MAPK1 protein		 CTD PMID:16020477 PMID:28038998 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO
EXP		 AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK3 protein]; AICA ribonucleotide inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [AICA ribonucleotide results in increased uptake of Deoxyglucose]; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of MAPK3 protein]
AICA ribonucleotide results in increased phosphorylation of MAPK3 protein
AICA ribonucleotide results in decreased phosphorylation of MAPK3 protein		 CTD PMID:11978788 PMID:16020477 PMID:28038998 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MFN1 mitofusin 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of MFN1 protein]; AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN1 protein] CTD PMID:27792760 NCBI chr 3:179,347,709...179,394,936
Ensembl chr 3:179,347,709...179,394,936 		JBrowse link
G MFN2 mitofusin 2 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of MFN2 protein]; AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN2 protein] CTD PMID:27792760 NCBI chr 1:11,980,215...12,013,508
Ensembl chr 1:11,980,181...12,015,211
Ensembl chr 1:11,980,181...12,015,211 		JBrowse link
G MMP13 matrix metallopeptidase 13 multiple interactions EXP AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein] CTD PMID:27688165 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732 		JBrowse link
G MMP2 matrix metallopeptidase 2 decreases activity EXP AICA ribonucleotide results in decreased activity of MMP2 protein CTD PMID:20590612 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 decreases activity EXP AICA ribonucleotide results in decreased activity of MMP9 protein CTD PMID:20590612 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases activity
decreases phosphorylation
multiple interactions		 EXP
ISO		 AICA ribonucleotide results in decreased activity of MTOR protein
AICA ribonucleotide results in decreased phosphorylation of MTOR protein
AICA ribonucleotide promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]
AICA ribonucleotide promotes the reaction [Cadmium results in decreased phosphorylation of MTOR protein]		 CTD PMID:19625624 PMID:21767558 PMID:27363783 PMID:28041982 NCBI chr 1:11,106,535...11,273,497
Ensembl chr 1:11,106,535...11,262,551 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of NCF1 protein] CTD PMID:21195169 NCBI chr 7:74,773,962...74,789,376
Ensembl chr 7:74,773,962...74,789,376 		JBrowse link
G NCF2 neutrophil cytosolic factor 2 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of NCF2 protein] CTD PMID:21195169 NCBI chr 1:183,555,562...183,590,914
Ensembl chr 1:183,555,563...183,590,876
Ensembl chr 1:183,555,563...183,590,876 		JBrowse link
G NCF4 neutrophil cytosolic factor 4 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of NCF4 protein] CTD PMID:21195169 NCBI chr22:36,861,006...36,878,015
Ensembl chr22:36,860,988...36,878,017 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein] CTD PMID:22025971 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]		 CTD PMID:24465016 PMID:25108154 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]] CTD PMID:25108154 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 decreases expression ISO AICA ribonucleotide results in decreased expression of NR0B2 mRNA CTD PMID:24428821 NCBI chr 1:26,911,489...26,914,110
Ensembl chr 1:26,911,489...26,913,975 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 decreases expression ISO AICA ribonucleotide results in decreased expression of NR1H4 mRNA; AICA ribonucleotide results in decreased expression of NR1H4 protein CTD PMID:27090119 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Phenobarbital results in increased localization of and results in increased activity of NR1I3 protein]; AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]; PRKAA2 protein promotes the reaction [AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]] CTD PMID:20686344 PMID:22815988 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302 		JBrowse link
G NRF1 nuclear respiratory factor 1 multiple interactions
increases expression		 ISO dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of NRF1 mRNA] CTD PMID:20438809 NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase multiple interactions ISO AICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of OPA1 protein]; AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of OPA1 protein] CTD PMID:27792760 NCBI chr 3:193,593,149...193,697,811
Ensembl chr 3:193,593,144...193,697,811 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA protein] CTD PMID:19699196 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO
EXP		 AICA ribonucleotide inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA]
AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of PPARG protein]		 CTD PMID:25108154 PMID:27688165 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions
increases expression
decreases expression		 ISO
EXP		 dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of PPARGC1A mRNA]
AICA ribonucleotide results in decreased expression of PPARGC1A mRNA
AICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; dorsomorphin promotes the reaction [AICA ribonucleotide results in decreased expression of PPARGC1A mRNA]
AICA ribonucleotide inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARGC1A protein]		 CTD PMID:20438809 PMID:23090186 PMID:24428821 PMID:25522270 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation
multiple interactions
increases expression
increases activity		 ISO
EXP		 AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein]
AICA ribonucleotide promotes the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA]; Quercetin promotes the reaction [AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 protein]
AICA ribonucleotide results in increased expression of PRKAA1 protein modified form
[AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein] which results in decreased secretion of Progesterone; AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]; AICA ribonucleotide inhibits the reaction [Sodium Chloride, Dietary results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; AICA ribonucleotide inhibits the reaction [Sodium Chloride, Dietary results in increased expression of PRKAA1 mRNA]
AICA ribonucleotide results in increased activity of PRKAA1 protein		 CTD PMID:12519745 PMID:16020477 PMID:16873680 PMID:19293639 PMID:20349193 PMID:21195169 PMID:21205922 PMID:23266269 PMID:24465016 PMID:25743752 PMID:28298333 NCBI chr 5:40,759,379...40,798,195
Ensembl chr 5:40,759,379...40,798,374 		JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions
increases phosphorylation		 EXP
ISO		 AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA2 protein; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA]
PRKAA2 protein promotes the reaction [AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]]
AICA ribonucleotide results in increased phosphorylation of PRKAA2 protein
PRKAA2 protein affects the reaction [AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form affects the susceptibility to Glucose deficiency]]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 mRNA]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 protein]		 CTD PMID:15806154 PMID:16873680 PMID:18482975 PMID:21205922 PMID:21454484 PMID:22815988 NCBI chr 1:56,645,314...56,715,335
Ensembl chr 1:56,645,314...56,715,335 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases activity		 ISO 1-Butanol inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; Genistein inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; GRB2 protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] CTD PMID:11978788 NCBI chr 1:2,050,411...2,185,395
Ensembl chr 1:2,050,411...2,185,395 		JBrowse link
G PTEN phosphatase and tensin homolog increases response to substance EXP PTEN protein results in increased susceptibility to AICA ribonucleotide CTD PMID:19625624 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22025971 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423 		JBrowse link
G PTK2B protein tyrosine kinase 2 beta multiple interactions ISO AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PTK2B protein; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of MAPK3 protein]; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] CTD PMID:11978788 NCBI chr 8:27,311,478...27,459,391
Ensembl chr 8:27,311,482...27,459,391 		JBrowse link
G RAC1 Rac family small GTPase 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of RAC1 protein] CTD PMID:21195169 NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO RAF1 protein affects the reaction [AICA ribonucleotide results in increased uptake of Deoxyglucose] CTD PMID:11978788 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,583,601...12,664,226
Ensembl chr 3:12,583,601...12,664,226 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO AICA ribonucleotide inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of RELA protein]
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]; Niacinamide inhibits the reaction [AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]		 CTD PMID:22058332 PMID:25108154 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090 		JBrowse link
G RPS6 ribosomal protein S6 decreases phosphorylation EXP AICA ribonucleotide results in decreased phosphorylation of RPS6 protein CTD PMID:19625624 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of RPS6KB1 protein]
AICA ribonucleotide results in decreased phosphorylation of RPS6KB1 protein		 CTD PMID:15342961 PMID:21195169 PMID:28041982 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574 		JBrowse link
G SIRT1 sirtuin 1 multiple interactions
increases expression		 ISO
EXP		 [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to AICA ribonucleotide
AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]
AICA ribonucleotide results in increased expression of SIRT1 protein
AICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]; AICA ribonucleotide inhibits the reaction [Streptozocin results in decreased activity of SIRT1 protein]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of SIRT1 protein]		 CTD PMID:22058332 PMID:23090186 PMID:24465016 PMID:25108154 PMID:27688165 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SLC10A1 solute carrier family 10 member 1 decreases expression ISO AICA ribonucleotide results in decreased expression of SLC10A1 mRNA CTD PMID:27090119 NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241 		JBrowse link
G SLC15A1 solute carrier family 15 member 1 decreases activity EXP AICA ribonucleotide results in decreased activity of SLC15A1 protein CTD PMID:22108913 NCBI chr13:98,683,801...98,752,672
Ensembl chr13:98,683,801...98,752,672 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions
increases localization		 ISO 1-Butanol inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]; Genistein inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]; U 0126 inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]; wortmannin inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]
AICA ribonucleotide inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA]		 CTD PMID:11978788 PMID:21802492 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 decreases expression ISO AICA ribonucleotide results in decreased expression of SLCO1A2 mRNA CTD PMID:27090119 NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
increases expression		 EXP AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of SOD2 mRNA]
AICA ribonucleotide results in increased expression of SOD2 mRNA; AICA ribonucleotide results in increased expression of SOD2 protein		 CTD PMID:25065674 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G STK11 serine/threonine kinase 11 multiple interactions EXP AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein] CTD PMID:27688165 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431
Ensembl chr19:1,177,558...1,228,431 		JBrowse link
G TBC1D1 TBC1 domain family member 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D1 protein] CTD PMID:26627467 NCBI chr 4:37,891,084...38,139,173
Ensembl chr 4:37,891,084...38,139,175 		JBrowse link
G TBC1D4 TBC1 domain family member 4 multiple interactions ISO AICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D4 protein] CTD PMID:24343960 PMID:26627467 NCBI chr13:75,283,503...75,483,144
Ensembl chr13:75,283,503...75,482,169 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of PPARG protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein] CTD PMID:27688165 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein] CTD PMID:27688165 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO
EXP		 AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
AICA ribonucleotide inhibits the reaction [TNF protein promotes the reaction [Oxygen deficiency results in increased expression of GPR68 mRNA]]; AICA ribonucleotide inhibits the reaction [TNF protein results in increased expression of GPR68 mRNA]
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]		 CTD PMID:22025971 PMID:25108154 PMID:28174749 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions ISO AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A protein] CTD PMID:22025971 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114 		JBrowse link
G TP53 tumor protein p53 multiple interactions EXP [resveratrol co-treated with AICA ribonucleotide] inhibits the reaction [Glucose results in increased expression of TP53 protein] CTD PMID:26188290 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TXNIP thioredoxin interacting protein multiple interactions ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein] CTD PMID:29031535 NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579 		JBrowse link
G UCP2 uncoupling protein 2 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Indican results in decreased expression of UCP2 mRNA] CTD PMID:25703824 NCBI chr11:73,974,671...73,983,202
Ensembl chr11:73,974,672...73,983,246
Ensembl chr11:73,974,672...73,983,246 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP AICA ribonucleotide inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased secretion of VEGFA protein] CTD PMID:30724446 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
SAICAR term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PKM pyruvate kinase M1/2 multiple interactions EXP Glucose deficiency promotes the reaction [SAICAR binds to and results in increased activity of PKM protein] CTD PMID:23086999 NCBI chr15:72,199,029...72,231,389
Ensembl chr15:72,199,029...72,231,822 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24387
    chemical entity 24355
      atom 24344
        nonmetal atom 24050
          nitrogen atom 20864
            nitrogen molecular entity 20864
              organonitrogen compound 20535
                carboxamide 18752
                  monocarboxylic acid amide 15714
                    1-ribosylimidazolecarboxamide 108
                      1-(phosphoribosyl)imidazolecarboxamide 102
                        1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide 0
                        5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate 0
                        5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide 0
                        5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide 0
                        AICA ribonucleotide 101
                        SAICAR 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 24387
    subatomic particle 24344
      composite particle 24344
        hadron 24344
          baryon 24344
            nucleon 24344
              atomic nucleus 24344
                atom 24344
                  main group element atom 24191
                    p-block element atom 24191
                      chalcogen 23230
                        oxygen atom 23105
                          oxygen molecular entity 23105
                            hydroxides 22353
                              oxoacid 21463
                                pnictogen oxoacid 10798
                                  phosphorus oxoacid 9582
                                    phosphoric acids 8298
                                      phosphoric acid 8298
                                        phosphoric acid derivative 7969
                                          phosphate 7969
                                            organic phosphate 7968
                                              carbohydrate phosphate 1743
                                                phospho sugar 1666
                                                  aldose phosphate 1664
                                                    aldopentose phosphate 1658
                                                      ribose phosphate 1653
                                                        1-(phosphoribosyl)imidazole 102
                                                          1-(phosphoribosyl)imidazolecarboxamide 102
                                                            1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide 0
                                                            5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate 0
                                                            5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide 0
                                                            5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide 0
                                                            AICA ribonucleotide 101
                                                            SAICAR 1
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