elemental sodium - Ontology Report

Dipyrone results in decreased activity of PTGS1 protein alternative form

PMID:12242329

NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819

sodium arsenite

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

GSR

glutathione-disulfide reductase

multiple interactions
decreases activity

[monoisoamyl-2,3-dimercaptosuccinate co-treated with Succimer] inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]

PMID:18163546

NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752

HSP70

heat shock protein 70

increases expression
multiple interactions

sodium arsenite results in increased expression of HSP70 protein
carvacrol promotes the reaction [sodium arsenite results in increased expression of HSP70 protein]; leucinostatin A promotes the reaction [sodium arsenite results in increased expression of HSP70 protein]

PMID:31940135

NCBI chr12:1,285,282...1,287,670

sodium chloride

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CLDN4

claudin 4

increases expression
multiple interactions

Sodium Chloride results in increased expression of CLDN4 protein
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]

NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145

JUN

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Sodium Chloride results in increased expression of JUN protein
pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]

NCBI chr 5:50,966,698...50,968,939

MAPK1

mitogen-activated protein kinase 1

increases phosphorylation
multiple interactions

Sodium Chloride results in increased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]

NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998

MAPK3

mitogen-activated protein kinase 3

increases phosphorylation
multiple interactions

Sodium Chloride results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]

NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425

MAPK8

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]

NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401

MAPK9

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]

NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119

SOD2

superoxide dismutase 2

increases expression

Sodium Chloride results in increased expression of SOD2 protein

PMID:22718889

NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706

SP1

Sp1 transcription factor

multiple interactions
increases expression

pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]