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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cirsiliol
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Accession:CHEBI:3719 term browser browse the term
Definition:A dimethoxyflavone that is flavone substituted by methoxy groups at positions 6 and 7 and hydroxy groups at positions 5, 3' and 4' respectively.
Synonyms:exact_synonym: 2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one
 related_synonym: 3',4',5-trihydroxy-6,7-dimethoxyflavone;   6,7-dimethoxy-5,3',4'-trihydroxyflavone;   Formula=C17H14O7;   InChI=1S/C17H14O7/c1-22-14-7-13-15(16(21)17(14)23-2)11(20)6-12(24-13)8-3-4-9(18)10(19)5-8/h3-7,18-19,21H,1-2H3;   InChIKey=IMEYGBIXGJLUIS-UHFFFAOYSA-N;   SMILES=COc1cc2oc(cc(=O)c2c(O)c1OC)-c1ccc(O)c(O)c1
 xref: CAS:34334-69-5;   KEGG:C10033;   KNApSAcK:C00001033;   LIPID_MAPS_instance:LMPK12111227
 xref_mesh: MESH:C039824
 xref: PMID:23902763;   PMID:24689280;   PMID:25140335;   Reaxys:1354524


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cirsiliol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
increases metabolic processing		 ISO cirsiliol results in decreased activity of CYP1A1 protein
cirsiliol results in increased expression of CYP1A1 mRNA
CYP1A1 protein results in increased metabolism of cirsiliol		 CTD PMID:19601638 PMID:21482471 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
decreases activity
increases metabolic processing		 ISO cirsiliol results in increased expression of CYP1B1 mRNA
cirsiliol results in decreased activity of CYP1B1 protein
CYP1B1 protein results in increased metabolism of cirsiliol		 CTD PMID:19601638 PMID:21482471 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        biochemical role 19549
          metabolite 19537
            flavone 97
              cirsiliol 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  oxacycle 17903
                                    benzopyran 11971
                                      1-benzopyran 11725
                                        flavonoid 7225
                                          anthoxanthin 4584
                                            flavones 4584
                                              methoxyflavone 493
                                                dimethoxyflavone 41
                                                  cirsiliol 2
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