Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cirsiliol
go back to main search page
Accession:CHEBI:3719 term browser browse the term
Definition:A dimethoxyflavone that is flavone substituted by methoxy groups at positions 6 and 7 and hydroxy groups at positions 5, 3' and 4' respectively.
Synonyms:exact_synonym: 2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one
 related_synonym: 3',4',5-trihydroxy-6,7-dimethoxyflavone;   6,7-dimethoxy-5,3',4'-trihydroxyflavone;   Formula=C17H14O7;   InChI=1S/C17H14O7/c1-22-14-7-13-15(16(21)17(14)23-2)11(20)6-12(24-13)8-3-4-9(18)10(19)5-8/h3-7,18-19,21H,1-2H3;   InChIKey=IMEYGBIXGJLUIS-UHFFFAOYSA-N;   SMILES=COc1cc2oc(cc(=O)c2c(O)c1OC)-c1ccc(O)c(O)c1
 xref: CAS:34334-69-5;   KEGG:C10033;   KNApSAcK:C00001033;   LIPID_MAPS_instance:LMPK12111227
 xref_mesh: MESH:C039824
 xref: PMID:23902763;   PMID:24689280;   PMID:25140335;   Reaxys:1354524



show annotations for term's descendants           Sort by:
cirsiliol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
increases metabolic processing
ISO cirsiliol results in decreased activity of CYP1A1 protein
cirsiliol results in increased expression of CYP1A1 mRNA
CYP1A1 protein results in increased metabolism of cirsiliol
CTD PMID:19601638 PMID:21482471 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
decreases activity
increases metabolic processing
ISO cirsiliol results in increased expression of CYP1B1 mRNA
cirsiliol results in decreased activity of CYP1B1 protein
CYP1B1 protein results in increased metabolism of cirsiliol
CTD PMID:19601638 PMID:21482471 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        biochemical role 19588
          metabolite 19574
            flavone 92
              cirsiliol 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                organic heterocyclic compound 18906
                                  oxacycle 17850
                                    benzopyran 11796
                                      1-benzopyran 11539
                                        flavonoid 6906
                                          anthoxanthin 4541
                                            flavones 4541
                                              methoxyflavone 478
                                                dimethoxyflavone 41
                                                  cirsiliol 2
paths to the root