lead nitrate - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	lead nitrate	go back to main search page
Accession:	CHEBI:37187	browse the term
Definition:	A lead coordination entity that has formula N2O6Pb.
Synonyms:	exact_synonym:	lead dinitrate; lead(2+) nitrate; lead(II) nitrate
	related_synonym:	Blei(II)-nitrat; Formula=N2O6Pb; InChI=1S/2NO3.Pb/c22-1(3)4;/q2-1;+2; InChIKey=RLJMLMKIBZAXJO-UHFFFAOYSA-N; SMILES=[O-][N+](=O)O[Pb]O[N+]([O-])=O; [Pb(NO3)2]; plumbous nitrate
	xref:	CAS:10099-74-8; Gmelin:7801; KEGG:C15234
	xref_mesh:	MESH:C017461
	xref:	MolBase:1766

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Genes (179)

lead nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aconitase 1

decreases expression
multiple interactions

lead nitrate results in decreased expression of ACO1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in decreased expression of ACO1 protein]

NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769

G

actin alpha 1, skeletal muscle

increases expression

lead nitrate results in increased expression of ACTA1 protein

NCBI chr 1:229,431,245...229,434,094
Ensembl chr 1:229,430,365...229,434,104

G

aryl hydrocarbon receptor

multiple interactions
increases expression

AHR promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; AHR promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]
lead nitrate results in increased expression of AHR mRNA; lead nitrate results in increased expression of AHR protein

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

A-kinase anchoring protein 3

decreases expression

lead nitrate results in decreased expression of AKAP3 mRNA

NCBI chr12:4,615,518...4,649,051
Ensembl chr12:4,615,508...4,649,051

G

aminolevulinate dehydratase

multiple interactions
decreases activity

lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]
lead nitrate results in decreased activity of ALAD protein

NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290

G

apoptotic peptidase activating factor 1

decreases expression
multiple interactions

lead nitrate results in decreased expression of APAF1 protein
mangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein]

NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,149...98,735,433

G

Rho GDP dissociation inhibitor beta

increases expression

lead nitrate results in increased expression of ARHGDIB protein

NCBI chr12:14,942,015...14,961,601
Ensembl chr12:14,942,031...14,961,728

G

arrestin domain containing 5

decreases expression

lead nitrate results in decreased expression of ARRDC5 mRNA

NCBI chr19:4,890,437...4,916,820
Ensembl chr19:4,890,437...4,902,948

G

antizyme inhibitor 2

decreases expression

lead nitrate results in decreased expression of AZIN2 mRNA

NCBI chr 1:33,081,153...33,166,795
Ensembl chr 1:33,081,104...33,123,492

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

mangiferin inhibits the reaction [lead nitrate results in increased expression of BAX protein]
[lead nitrate results in increased abundance of Lead] which results in increased expression of BAX mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of BAX mRNA]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of BAX mRNA]

PMID:23451106 PMID:30738203

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression
multiple interactions

lead nitrate results in decreased expression of BCL2 protein
[lead nitrate results in increased abundance of Lead] which results in decreased expression of BCL2 mRNA
mangiferin inhibits the reaction [lead nitrate results in decreased expression of BCL2 protein]

PMID:23451106 PMID:30738203

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

chromosome 1 open reading frame 56

decreases expression

lead nitrate results in decreased expression of C2H1ORF56 mRNA

NCBI chr 1:151,047,751...151,051,420
Ensembl chr 1:151,047,751...151,051,986

G

caspase 3

increases expression
multiple interactions
increases activity

lead nitrate results in increased expression of CASP3 protein
[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP3 protein; [lead nitrate results in increased abundance of Lead] which results in increased expression of CASP3 mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP3 protein]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of CASP3 mRNA]
puerarin inhibits the reaction [lead nitrate results in increased activity of CASP3 protein]
mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP3 protein]

PMID:23451106 PMID:24505050 PMID:30738203

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 7

multiple interactions
decreases expression

lead nitrate affects the reaction [CASP7 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CASP7 affects the expression of MT2 mRNA]
lead nitrate results in decreased expression of CASP7 mRNA

NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907

G

caspase 9

multiple interactions
increases expression

mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP9 protein]
[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP9 protein; [lead nitrate results in increased abundance of Lead] which results in increased expression of CASP9 mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP9 protein]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of CASP9 mRNA]

PMID:23451106 PMID:30738203

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

catalase

decreases activity
multiple interactions

lead nitrate results in decreased activity of CAT protein
[lead nitrate results in increased abundance of Lead] which results in decreased activity of CAT protein; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased activity of CAT protein]
Ashwagandha inhibits the reaction [lead nitrate results in decreased activity of CAT protein]; puerarin inhibits the reaction [lead nitrate results in decreased activity of CAT protein]
mangiferin inhibits the reaction [lead nitrate results in decreased activity of CAT protein]

PMID:23315276 PMID:23451106 PMID:24987671 PMID:30738203

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

cyclin G1

multiple interactions

lead nitrate affects the reaction [CCNG1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT2 mRNA]

NCBI chr 5:163,437,571...163,457,640
Ensembl chr 5:163,437,569...163,448,199

G

CD86 molecule

increases expression

lead nitrate results in increased expression of CD86 protein

NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139

G

chromodomain Y like

decreases expression

lead nitrate results in decreased expression of CDYL mRNA

NCBI chr 6:4,706,138...4,955,544
Ensembl chr 6:4,706,159...4,955,551

G

component of inhibitor of nuclear factor kappa B kinase complex

increases phosphorylation
multiple interactions

lead nitrate results in increased phosphorylation of CHUK protein
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of CHUK protein]

NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596

G

cytochrome c oxidase subunit 8C

decreases expression

lead nitrate results in decreased expression of COX8C mRNA

NCBI chr14:93,347,182...93,348,356
Ensembl chr14:93,347,182...93,348,356

G

cysteine rich secretory protein 2

decreases expression

lead nitrate results in decreased expression of CRISP2 mRNA

NCBI chr 6:49,676,652...49,714,220
Ensembl chr 6:49,692,358...49,713,590

G

crystallin alpha A

affects metabolic processing

lead nitrate affects the metabolism of CRYAA protein

NCBI chr21:43,169,008...43,172,810
Ensembl chr21:43,169,008...43,172,810

G

crystallin alpha B

affects metabolic processing

lead nitrate affects the metabolism of CRYAB protein

NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722

G

cystatin 8

decreases expression

lead nitrate results in decreased expression of CST8 mRNA

NCBI chr20:23,491,117...23,507,124
Ensembl chr20:23,491,101...23,496,010

G

catenin alpha 1

multiple interactions

lead nitrate affects the reaction [CTNNA1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT2 mRNA]

NCBI chr 5:138,753,425...138,935,034
Ensembl chr 5:138,610,967...138,935,034

G

catenin beta 1

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased expression of and affects the localization of CTNNB1 protein; [lead nitrate results in increased abundance of Lead] which results in decreased expression of CTNNB1 mRNA; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of and affects the localization of CTNNB1 protein]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of CTNNB1 mRNA]
lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of CTNNB1 mRNA]

PMID:30731080 PMID:35738543

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

G

cut like homeobox 2

multiple interactions

lead nitrate affects the reaction [CUX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT2 mRNA]

NCBI chr12:111,034,165...111,350,554
Ensembl chr12:111,034,165...111,350,554

G

C-X-C motif chemokine ligand 8

increases expression

lead nitrate results in increased expression of CXCL8 protein

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

cytochrome P450 family 1 subfamily A member 1

multiple interactions
increases expression

lead nitrate inhibits the reaction [1,2,5,6-dibenzanthracene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benz(a)anthracene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(b)fluoranthene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(k)fluoranthene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(k)fluoranthene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; lead nitrate promotes the reaction [benzo(k)fluoranthene results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [lead nitrate results in increased expression of CYP1A1 mRNA]
lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; resveratrol inhibits the reaction [lead nitrate results in increased expression of CYP1A1 mRNA]
lead nitrate results in increased expression of CYP1A1 mRNA; lead nitrate results in increased expression of CYP1A1 protein

PMID:8902619 PMID:11162773 PMID:11408366 PMID:17889500 PMID:23391631 More...

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

decreases activity
multiple interactions

lead nitrate results in decreased activity of CYP1A2 protein
lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; lead nitrate results in decreased expression of and results in decreased activity of CYP1A2 protein

PMID:8902619 PMID:11162773

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 2 subfamily C member 18

increases expression

lead nitrate results in increased expression of CYP2C11 mRNA

NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190

G

cytochrome P450 family 4 subfamily A member 22

increases expression

lead nitrate results in increased expression of CYP4A1 mRNA

NCBI chr 1:47,137,441...47,149,727
Ensembl chr 1:47,137,435...47,149,727

G

cytochrome P450 family 51 subfamily A member 1

increases expression
multiple interactions

lead nitrate results in increased expression of CYP51 mRNA
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]

PMID:15475176 PMID:22293356

NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,084,987...92,134,803

G

cytochrome P450 family 7 subfamily A member 1

decreases expression
multiple interactions

lead nitrate results in decreased expression of CYP7A1 mRNA
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]

PMID:15475176 PMID:16049268 PMID:22293356

NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163

G

DNA damage inducible transcript 3

increases expression

lead nitrate results in increased expression of DDIT3 mRNA

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

dickkopf WNT signaling pathway inhibitor 1

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 mRNA; [lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 protein]

NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042

G

dentin matrix acidic phosphoprotein 1

multiple interactions

lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of DMP1 mRNA]

NCBI chr 4:87,650,280...87,664,357
Ensembl chr 4:87,650,280...87,664,361

G

deoxyribonuclease 1

multiple interactions

lead nitrate affects the reaction [DNASE1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT2 mRNA]

NCBI chr16:3,611,760...3,665,461
Ensembl chr16:3,611,728...3,680,143

G

DNA methyltransferase 3 alpha

multiple interactions
decreases expression

4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]
lead nitrate results in decreased expression of DNMT3A mRNA; lead nitrate results in decreased expression of DNMT3A protein

NCBI chr 2:25,227,874...25,342,590
Ensembl chr 2:25,227,855...25,342,590

G

dentin sialophosphoprotein

multiple interactions

lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of DSPP mRNA]

NCBI chr 4:87,608,529...87,616,873
Ensembl chr 4:87,608,529...87,616,873

G

E2F transcription factor 1

multiple interactions

E2F1 protein inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; lead nitrate inhibits the reaction [E2F1 protein results in decreased expression of PTGS2 mRNA]

NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385

G

EGF like domain multiple 8

increases expression

lead nitrate results in increased expression of EGFL8 protein

NCBI chr 6:32,164,595...32,168,281
Ensembl chr 6:32,164,595...32,168,281

G

epidermal growth factor receptor

multiple interactions
increases phosphorylation

EGFR mutant form affects the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; EGFR mutant form affects the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; EGFR mutant form affects the reaction [lead nitrate results in increased secretion of Dinoprostone]; EGFR promotes the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of EGFR protein]

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

eukaryotic translation initiation factor 2 alpha kinase 1

increases response to substance
multiple interactions

EIF2AK1 gene mutant form results in increased susceptibility to lead nitrate
[lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Bilirubin; [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Malondialdehyde; [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased expression of HAMP mRNA

NCBI chr 7:6,022,247...6,059,175
Ensembl chr 7:6,022,247...6,059,175

G

eukaryotic translation initiation factor 4E binding protein 1

increases phosphorylation
multiple interactions

lead nitrate results in increased phosphorylation of EIF4EBP1 protein
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of EIF4EBP1 protein]

NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365

G

ERCC excision repair 1, endonuclease non-catalytic subunit

multiple interactions

lead nitrate affects the reaction [ERCC1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT2 mRNA]

NCBI chr19:45,407,334...45,451,547
Ensembl chr19:45,407,334...45,478,828

G

ERCC excision repair 3, TFIIH core complex helicase subunit

multiple interactions

lead nitrate affects the reaction [ERCC3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT2 mRNA]

NCBI chr 2:127,257,290...127,294,144
Ensembl chr 2:127,257,290...127,294,166

G

ezrin

multiple interactions

lead nitrate affects the reaction [EZR affects the expression of MT1 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT2 mRNA]

NCBI chr 6:158,765,748...158,819,368
Ensembl chr 6:158,765,741...158,819,368

G

fatty acid binding protein 9

decreases expression

lead nitrate results in decreased expression of FABP9 mRNA

NCBI chr 8:81,458,253...81,461,579
Ensembl chr 8:81,458,253...81,461,579

G

farnesyl-diphosphate farnesyltransferase 1

increases expression

lead nitrate results in increased expression of FDFT1 mRNA

NCBI chr 8:11,795,582...11,839,298
Ensembl chr 8:11,795,573...11,839,395

G

farnesyl diphosphate synthase

increases expression

lead nitrate results in increased expression of FDPS mRNA

NCBI chr 1:155,308,866...155,320,665
Ensembl chr 1:155,308,748...155,320,666

G

four and a half LIM domains 1

decreases expression

lead nitrate results in decreased expression of FHL1 mRNA

NCBI chr X:136,146,702...136,211,359
Ensembl chr X:136,146,702...136,211,359

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

lead nitrate results in increased expression of FOS mRNA

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190

G

forkhead box A2

multiple interactions

lead nitrate affects the reaction [FOXA2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT2 mRNA]

NCBI chr20:22,580,998...22,585,490
Ensembl chr20:22,580,998...22,585,455

G

ferritin light chain

increases expression

lead nitrate results in increased expression of FTL protein

NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,967,896

G

glucose-6-phosphate dehydrogenase

decreases activity

lead nitrate results in decreased activity of G6PD protein

NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572

G

growth arrest and DNA damage inducible alpha

increases expression

lead nitrate results in increased expression of GADD45A mRNA

NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334

G

golgi associated RAB2 interactor 1B

decreases expression

lead nitrate results in decreased expression of GARIN1B mRNA

NCBI chr 7:128,709,061...128,731,743
Ensembl chr 7:128,709,061...128,731,743

G

glial fibrillary acidic protein

multiple interactions
increases expression

Ashwagandha inhibits the reaction [lead nitrate results in increased expression of GFAP mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in increased expression of GFAP protein]
lead nitrate results in increased expression of GFAP mRNA; lead nitrate results in increased expression of GFAP protein

NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937

G

gametogenetin binding protein 1 (pseudogene)

decreases expression

lead nitrate results in decreased expression of GGNBP1 mRNA

NCBI chr 6:33,583,699...33,589,026
Ensembl chr 6:33,583,699...33,589,026

G

growth hormone 1

multiple interactions
decreases secretion

lead nitrate inhibits the reaction [GHRH protein results in increased expression of GH1 protein]
lead nitrate results in decreased secretion of GH1 protein

NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839

G

growth hormone releasing hormone

multiple interactions

lead nitrate inhibits the reaction [GHRH protein results in increased expression of GH1 protein]

NCBI chr20:37,251,086...37,261,814
Ensembl chr20:37,251,086...37,261,819

G

gap junction protein alpha 5

multiple interactions
increases expression

lead nitrate affects the reaction [GJA5 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT2 mRNA]
lead nitrate results in increased expression of GJA5 mRNA

NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362

G

gap junction protein beta 2

multiple interactions

lead nitrate affects the reaction [GJB2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT2 mRNA]

NCBI chr13:20,187,470...20,192,938
Ensembl chr13:20,187,463...20,192,938

G

glutamate ionotropic receptor NMDA type subunit 2A

multiple interactions

lead nitrate affects the reaction [GRIN2A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT2 mRNA]

NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,183,337

G

glutamate ionotropic receptor NMDA type subunit 2C

increases expression

lead nitrate results in increased expression of GRIN2C mRNA

NCBI chr17:74,842,023...74,861,532
Ensembl chr17:74,842,023...74,861,504

G

germ cell associated 1

decreases expression

lead nitrate results in decreased expression of GSG1 mRNA

NCBI chr12:13,083,532...13,103,667
Ensembl chr12:13,083,532...13,103,683

G

glycogen synthase kinase 3 beta

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein]

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

glutathione-disulfide reductase

multiple interactions
decreases activity

mangiferin inhibits the reaction [lead nitrate results in decreased activity of GSR protein]

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

glutathione S-transferase alpha 1

multiple interactions
decreases expression

AHR promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; RELA promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; Resveratrol inhibits the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]

NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860

G

glutathione S-transferase theta 1

multiple interactions

lead nitrate affects the reaction [GSTT1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT2 mRNA]

G

hepcidin antimicrobial peptide

multiple interactions

[lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased expression of HAMP mRNA

NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143

G

high mobility group box 4

decreases expression

lead nitrate results in decreased expression of HMGB4 mRNA

NCBI chr 1:33,860,475...33,864,791
Ensembl chr 1:33,860,475...33,864,791

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression
multiple interactions

lead nitrate results in increased expression of HMGCR mRNA
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]

PMID:15475176 PMID:16705668 PMID:22293356

NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001

G

heme oxygenase 1

increases expression

lead nitrate results in increased expression of HMOX1 mRNA

PMID:23391631 PMID:34189835

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

hepatocyte nuclear factor 4 alpha

decreases expression

lead nitrate results in decreased expression of HNF4A mRNA

NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845

G

heat shock protein 90 alpha family class B member 1

multiple interactions

lead nitrate affects the reaction [HSP90AB1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT2 mRNA]

NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888

G

heat shock protein family A (Hsp70) member 2

multiple interactions
decreases expression
increases expression

Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA2 mRNA]
lead nitrate results in decreased expression of HSPA2 mRNA

PMID:21628963 PMID:24987671

NCBI chr14:64,535,905...64,543,237
Ensembl chr14:64,535,905...64,546,173

G

heat shock protein family A (Hsp70) member 5

increases expression

lead nitrate results in increased expression of HSPA5 protein
lead nitrate results in increased expression of HSPA5 mRNA

PMID:14971657 PMID:20435106

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

heat shock protein family A (Hsp70) member 9

multiple interactions
increases expression

Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA9 mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA9 protein]
lead nitrate results in increased expression of HSPA9 mRNA; lead nitrate results in increased expression of HSPA9 protein

NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,675

G

insulin like growth factor 2

multiple interactions

lead nitrate affects the reaction [IGF2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT2 mRNA]

NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391

G

insulin like growth factor binding protein 6

multiple interactions

lead nitrate affects the reaction [IGFBP6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT2 mRNA]

NCBI chr12:53,097,667...53,102,340
Ensembl chr12:53,097,436...53,102,345

G

interleukin 1 alpha

multiple interactions
increases expression

[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] results in decreased susceptibility to lead nitrate
lead nitrate results in increased expression of IL1A mRNA

NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493

G

interleukin 1 beta

multiple interactions
increases expression

[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] results in decreased susceptibility to lead nitrate
lead nitrate results in increased expression of IL1B mRNA
lead nitrate results in increased expression of IL1B mRNA; lead nitrate results in increased expression of IL1B protein

PMID:15475176 PMID:16049268 PMID:22293356

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 2

decreases secretion

lead nitrate results in decreased secretion of IL2 protein

NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725

G

interleukin 6 receptor

multiple interactions

lead nitrate affects the reaction [IL6RA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT2 mRNA]

NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450

G

INS-IGF2 readthrough

multiple interactions

[lead nitrate results in increased abundance of Lead] inhibits the reaction [Glucose results in increased secretion of INS1 protein]

NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209

G

IQ motif containing F1

decreases expression

lead nitrate results in decreased expression of IQCF1 mRNA

NCBI chr 3:51,894,876...51,903,353
Ensembl chr 3:51,894,876...51,903,353

G

IQ motif containing F5

decreases expression

lead nitrate results in decreased expression of IQCF5 mRNA

NCBI chr 3:51,873,721...51,875,601
Ensembl chr 3:51,873,721...51,875,601

G

integrin subunit alpha 6

multiple interactions

lead nitrate affects the reaction [ITGA6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT2 mRNA]

NCBI chr 2:172,427,336...172,506,459
Ensembl chr 2:172,234,216...172,506,459

G

integrin subunit alpha M

multiple interactions

lead nitrate affects the reaction [ITGAM affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT2 mRNA]

NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892

G

keratin 14

increases expression

lead nitrate results in increased expression of KRT14 protein

NCBI chr17:41,582,279...41,586,895
Ensembl chr17:41,582,279...41,586,895

G

lysosomal associated membrane protein 1

increases expression

lead nitrate results in increased expression of LAMP1 protein

NCBI chr13:113,297,239...113,323,672
Ensembl chr13:113,297,239...113,323,672

G

lysosomal associated membrane protein 2

increases expression

lead nitrate results in increased expression of LAMP2 protein

NCBI chr X:120,426,148...120,469,349
Ensembl chr X:120,426,148...120,469,365

G

lactate dehydrogenase C

decreases expression

lead nitrate results in decreased expression of LDHC mRNA

NCBI chr11:18,412,318...18,452,063
Ensembl chr11:18,412,318...18,452,063

G

leucine rich repeat containing 46

decreases expression

lead nitrate results in decreased expression of LRRC46 mRNA

NCBI chr17:47,831,670...47,837,719
Ensembl chr17:47,831,634...47,837,719

G

lymphotoxin alpha

multiple interactions

lead nitrate affects the reaction [LTA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT2 mRNA]

NCBI chr 6:31,560,610...31,574,324
Ensembl chr 6:31,572,054...31,574,324

G

LY6/PLAUR domain containing 4

decreases expression

lead nitrate results in decreased expression of LYPD4 mRNA

NCBI chr19:41,835,075...41,844,871
Ensembl chr19:41,837,074...41,844,697

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]

PMID:20850495 PMID:22502979 PMID:23451106

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]

PMID:20850495 PMID:22502979 PMID:23451106

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

membrane associated ring-CH-type finger 11

decreases expression

lead nitrate results in decreased expression of MARCHF11 mRNA

NCBI chr 5:16,067,139...16,179,791
Ensembl chr 5:16,067,139...16,180,762

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions

lead nitrate affects the reaction [MCL1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT2 mRNA]

NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738

G

MET proto-oncogene, receptor tyrosine kinase

multiple interactions

lead nitrate affects the reaction [MET affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT2 mRNA]

NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377

G

microsomal glutathione S-transferase 1

multiple interactions

lead nitrate affects the reaction [MGST1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT2 mRNA]

NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259

G

microRNA 139

increases expression

lead nitrate results in increased expression of MIR139 mRNA

NCBI chr11:72,615,063...72,615,130
Ensembl chr11:72,615,063...72,615,130

G

microRNA 142

increases expression

lead nitrate results in increased expression of MIR142 mRNA

NCBI chr17:58,331,232...58,331,318
Ensembl chr17:58,331,232...58,331,318

G

maestro heat like repeat family member 2B

decreases expression

lead nitrate results in decreased expression of MROH2B mRNA

NCBI chr 5:40,998,020...41,071,342
Ensembl chr 5:40,998,017...41,071,342

G

mitochondrially encoded cytochrome c oxidase I

multiple interactions
decreases expression

puerarin inhibits the reaction [lead nitrate results in decreased expression of COX1 mRNA]

NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445

G

mitochondrially encoded cytochrome c oxidase II

multiple interactions
decreases expression

puerarin inhibits the reaction [lead nitrate results in decreased expression of COX2 mRNA]

NCBI chr MT:7,586...8,269
Ensembl chr MT:7,586...8,269

G

mitochondrially encoded cytochrome c oxidase III

multiple interactions
decreases expression

puerarin inhibits the reaction [lead nitrate results in decreased expression of COX3 mRNA]

NCBI chr MT:9,207...9,990
Ensembl chr MT:9,207...9,990

G

metallothionein 1X

increases expression
multiple interactions
decreases response to substance
affects localization

lead nitrate results in increased expression of MT1 mRNA
lead nitrate affects the reaction [CASP7 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT1 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT1 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RAD23 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SERPINA1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT1 mRNA]; MT1 protein promotes the reaction [lead nitrate results in increased expression of SNCA mRNA]
MT1 results in decreased susceptibility to lead nitrate
lead nitrate affects the localization of MT1 protein

PMID:11891201 PMID:19542206

NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196

G

metallothionein 2A

multiple interactions
decreases response to substance

lead nitrate affects the reaction [CASP7 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT2 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT2 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT2 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT2 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT2 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RAD23 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SERPINA1B affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT2 mRNA]
MT2 results in decreased susceptibility to lead nitrate

NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497

G

mechanistic target of rapamycin kinase

increases phosphorylation
multiple interactions

lead nitrate results in increased phosphorylation of MTOR protein
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of MTOR protein]

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

lead nitrate affects the reaction [MYC affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT2 mRNA]

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

myosin heavy chain 6

decreases expression

lead nitrate results in decreased expression of MYH6 protein

NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273

G

myosin heavy chain 7

increases expression
multiple interactions

lead nitrate results in increased expression of MYH7 mRNA; lead nitrate results in increased expression of MYH7 protein
resveratrol inhibits the reaction [lead nitrate results in increased expression of MYH7 mRNA]

NCBI chr14:23,412,740...23,435,660
Ensembl chr14:23,412,740...23,435,660

G

neural cell adhesion molecule 1

multiple interactions
decreases expression

Ashwagandha inhibits the reaction [lead nitrate results in decreased expression of NCAM1 mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in decreased expression of NCAM1 protein]
lead nitrate results in decreased expression of NCAM1 mRNA; lead nitrate results in decreased expression of NCAM1 protein

NCBI chr11:112,961,420...113,278,436
Ensembl chr11:112,961,275...113,278,436

G

NFKB inhibitor alpha

decreases expression
multiple interactions

lead nitrate results in decreased expression of NFKBIA protein
mangiferin inhibits the reaction [lead nitrate results in decreased expression of NFKBIA protein]

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

NFKB inhibitor beta

multiple interactions

lead nitrate affects the reaction [NFKBIB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT2 mRNA]

NCBI chr19:38,899,666...38,908,889
Ensembl chr19:38,899,700...38,908,893

G

natriuretic peptide B

increases expression

lead nitrate results in increased expression of NPPB mRNA

NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945

G

NAD(P)H quinone dehydrogenase 1

increases expression

lead nitrate results in increased expression of NQO1 mRNA

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

nuclear receptor subfamily 0 group B member 2

decreases expression

lead nitrate results in decreased expression of NR0B2 mRNA

PMID:15475176 PMID:16049268

NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975

G

nuclear receptor subfamily 1 group H member 3

decreases expression

lead nitrate results in decreased expression of NR1H3 mRNA

NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033

G

nuclear receptor subfamily 5 group A member 2

increases expression

lead nitrate results in increased expression of NR5A2 mRNA

NCBI chr 1:200,027,710...200,177,415
Ensembl chr 1:200,027,614...200,177,420

G

NUMB endocytic adaptor protein

multiple interactions

lead nitrate affects the reaction [NUMB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT2 mRNA]

NCBI chr14:73,275,216...73,458,546
Ensembl chr14:73,275,107...73,466,167

G

outer dense fiber of sperm tails 1

decreases expression

lead nitrate results in decreased expression of ODF1 mRNA

NCBI chr 8:102,551,589...102,561,018
Ensembl chr 8:102,551,589...102,561,018

G

progestin and adipoQ receptor family member 5

decreases expression

lead nitrate results in decreased expression of PAQR5 mRNA

NCBI chr15:69,298,912...69,407,780
Ensembl chr15:69,298,912...69,407,780

G

protein inhibitor of activated STAT 2

multiple interactions

lead nitrate affects the reaction [PIAS2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT2 mRNA]

NCBI chr18:46,803,218...46,920,145
Ensembl chr18:46,803,218...46,920,160

G

phospholipase A2 group IVA

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; [lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone; EGFR mutant form affects the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; EGFR mutant form affects the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; EGFR promotes the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]

NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981

G

DNA polymerase delta 1, catalytic subunit

multiple interactions

lead nitrate affects the reaction [POLD1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT2 mRNA]

NCBI chr19:50,384,323...50,418,018
Ensembl chr19:50,384,204...50,418,018

G

POU class 3 homeobox 3

multiple interactions

lead nitrate affects the reaction [POU3F3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT2 mRNA]

NCBI chr 2:104,854,115...104,858,574
Ensembl chr 2:104,853,287...104,858,574

G

protamine 1

decreases expression

lead nitrate results in decreased expression of PRM1 mRNA

NCBI chr16:11,280,841...11,281,330
Ensembl chr16:11,280,841...11,281,330

G

protamine 3

decreases expression

lead nitrate results in decreased expression of PRM3 mRNA

NCBI chr16:11,273,199...11,273,629
Ensembl chr16:11,273,199...11,273,629

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PTGS2 protein]; [lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone; Decitabine promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; lead nitrate inhibits the reaction [E2F1 protein results in decreased expression of PTGS2 mRNA]; lead nitrate promotes the reaction [RB1 protein results in increased expression of PTGS2 mRNA]; RB1 protein promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PTGS2 protein]
lead nitrate results in increased expression of PTGS2 mRNA; lead nitrate results in increased expression of PTGS2 protein

PMID:20850495 PMID:21435385 PMID:24639330

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

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RB transcriptional corepressor 1

multiple interactions
increases expression

4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of RB1 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of RB1 protein]; lead nitrate promotes the reaction [RB1 protein results in increased expression of PTGS2 mRNA]; RB1 protein promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of RB1 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of RB1 protein]

NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436

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RB transcriptional corepressor like 2

multiple interactions

lead nitrate affects the reaction [RBL2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT2 mRNA]

NCBI chr16:53,434,471...53,491,648
Ensembl chr16:53,433,977...53,491,648

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RELA proto-oncogene, NF-kB subunit

multiple interactions
increases expression

mangiferin inhibits the reaction [lead nitrate results in increased expression of RELA protein]
lead nitrate results in increased expression of RELA mRNA; lead nitrate results in increased expression of RELA protein
RELA promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; RELA promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]

PMID:23451106 PMID:31682781

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

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RIB43A domain with coiled-coils 2

decreases expression

lead nitrate results in decreased expression of RIBC2 mRNA

NCBI chr22:45,413,693...45,432,509
Ensembl chr22:45,413,693...45,432,509

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ribosomal protein S6 kinase B1

increases phosphorylation
multiple interactions

lead nitrate results in increased phosphorylation of RPS6KB1 protein
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of RPS6KB1 protein]

NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574

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RUNX family transcription factor 1

multiple interactions

lead nitrate affects the reaction [RUNX1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT2 mRNA]

NCBI chr21:34,787,801...35,049,302
Ensembl chr21:34,787,801...36,004,667

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RUNX family transcription factor 2

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 mRNA; [lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 protein]
lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of RUNX2 mRNA]

PMID:30731080 PMID:35738543

NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349

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sperm mitochondria associated cysteine rich protein

decreases expression

lead nitrate results in decreased expression of SMCP mRNA

NCBI chr 1:152,878,322...152,885,047
Ensembl chr 1:152,878,322...152,885,047

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synuclein alpha

affects localization
multiple interactions
increases expression

lead nitrate affects the localization of SNCA protein
MT1 protein promotes the reaction [lead nitrate results in increased expression of SNCA mRNA]

NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315

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suppressor of cytokine signaling 1

multiple interactions

lead nitrate affects the reaction [SOCS1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT2 mRNA]

NCBI chr16:11,254,417...11,256,204
Ensembl chr16:11,254,417...11,256,204

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superoxide dismutase 1

multiple interactions
decreases activity

Ashwagandha inhibits the reaction [lead nitrate results in decreased activity of SOD1 protein]

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

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Sp3 transcription factor

multiple interactions
decreases expression

lead nitrate affects the reaction [SP3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT2 mRNA]
lead nitrate results in decreased expression of SP3 mRNA

NCBI chr 2:173,900,775...173,965,702
Ensembl chr 2:173,880,850...173,965,373

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spermatogenesis associated 18

decreases expression

lead nitrate results in decreased expression of SPATA18 mRNA

NCBI chr 4:52,051,304...52,097,299
Ensembl chr 4:52,051,304...52,097,299

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spermatogenesis associated 20

decreases expression

lead nitrate results in decreased expression of SPATA20 mRNA

NCBI chr17:50,547,174...50,555,852
Ensembl chr17:50,543,058...50,555,852

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spermatogenesis associated 21

decreases expression

lead nitrate results in decreased expression of SPATA21 mRNA

NCBI chr 1:16,395,677...16,437,842
Ensembl chr 1:16,387,117...16,437,424

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spermatogenesis associated 6

decreases expression

lead nitrate results in decreased expression of SPATA6 mRNA

NCBI chr 1:48,261,389...48,472,204
Ensembl chr 1:48,295,373...48,472,208

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sequestosome 1

multiple interactions
increases expression

lead nitrate affects the reaction [SQSTM1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT2 mRNA]
puerarin inhibits the reaction [lead nitrate results in increased expression of SQSTM1 protein]

PMID:11891201 PMID:27762461

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

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sterol regulatory element binding transcription factor 2

increases expression

lead nitrate results in increased expression of SREBF2 mRNA

PMID:15475176 PMID:16705668

NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,105...41,907,306

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small ubiquitin like modifier 1

multiple interactions

lead nitrate affects the reaction [SUMO1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT2 mRNA]

NCBI chr 2:202,206,171...202,238,597
Ensembl chr 2:202,206,182...202,238,599

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T-box transcription factor 2

multiple interactions

lead nitrate affects the reaction [TBX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT2 mRNA]

NCBI chr17:61,399,843...61,409,466
Ensembl chr17:61,399,843...61,409,466

G

tektin 2

decreases expression

lead nitrate results in decreased expression of TEKT2 mRNA

NCBI chr 1:36,084,094...36,088,275
Ensembl chr 1:36,084,094...36,088,275

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tektin 4

decreases expression

lead nitrate results in decreased expression of TEKT4 mRNA

NCBI chr 2:94,871,430...94,876,823
Ensembl chr 2:94,871,430...94,876,823

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tropomodulin 1

decreases expression

lead nitrate results in decreased expression of TMOD1 mRNA

NCBI chr 9:97,501,180...97,601,743
Ensembl chr 9:97,501,180...97,601,743

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tumor necrosis factor

multiple interactions
increases expression

[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]
Lead nitrate increases expression of Tnf mRNA in liver

CTD
RGD

PMID:15475176 PMID:16049268 PMID:22293356 PMID:9049203

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

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TNF receptor superfamily member 1A

multiple interactions

lead nitrate affects the reaction [TNFRSF1A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT2 mRNA]

NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114

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TNF receptor superfamily member 1B

multiple interactions

lead nitrate affects the reaction [TNFRSF1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT2 mRNA]

NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228

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transition protein 1

decreases expression

lead nitrate results in decreased expression of TNP1 mRNA

NCBI chr 2:216,859,458...216,860,064
Ensembl chr 2:216,859,458...216,860,064

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transition protein 2

decreases expression

lead nitrate results in decreased expression of TNP2 mRNA

NCBI chr16:11,267,857...11,269,325
Ensembl chr16:11,267,748...11,269,533

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tumor protein p53

multiple interactions
increases expression

[lead nitrate results in increased abundance of Lead] which results in increased expression of TP53 mRNA; AHR promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]; RELA promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of TP53 mRNA]

PMID:30738203 PMID:31682781

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546

G

tubulin polymerization promoting protein family member 2

decreases expression

lead nitrate results in decreased expression of TPPP2 mRNA

NCBI chr14:21,024,299...21,036,352
Ensembl chr14:21,024,109...21,036,276

G

tripartite motif containing 27

multiple interactions

lead nitrate affects the reaction [TRIM27 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT2 mRNA]

NCBI chr 6:28,903,002...28,923,985
Ensembl chr 6:28,903,002...28,923,988

G

transient receptor potential cation channel subfamily M member 2

multiple interactions

lead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]

NCBI chr21:44,353,621...44,442,644
Ensembl chr21:44,350,163...44,443,081

G

TSC22 domain family member 3

multiple interactions

[lead nitrate results in increased abundance of Lead] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA]

NCBI chr X:107,713,221...107,775,988
Ensembl chr X:107,713,221...107,777,342

G

tumor susceptibility 101

multiple interactions

lead nitrate affects the reaction [TSG101 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT2 mRNA]

NCBI chr11:18,480,311...18,526,942
Ensembl chr11:18,468,336...18,526,951

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testis specific serine kinase 2

decreases expression

lead nitrate results in decreased expression of TSSK2 mRNA

NCBI chr22:19,131,308...19,132,622
Ensembl chr22:19,131,308...19,132,622

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testis specific serine kinase 3

decreases expression

lead nitrate results in decreased expression of TSSK3 mRNA

NCBI chr 1:32,362,539...32,364,312
Ensembl chr 1:32,351,521...32,364,312

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transcription termination factor 1

multiple interactions

lead nitrate affects the reaction [TTF1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT2 mRNA]

NCBI chr 9:132,375,548...132,406,840
Ensembl chr 9:132,375,548...132,406,851

G

tubulin alpha 8

decreases expression

lead nitrate results in decreased expression of TUBA8 mRNA

NCBI chr22:18,110,809...18,131,732
Ensembl chr22:18,110,100...18,146,683

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TUB like protein 2

decreases expression

lead nitrate results in decreased expression of TULP2 mRNA

NCBI chr19:48,880,967...48,898,744
Ensembl chr19:48,880,965...48,898,744

G

Wnt family member 1

multiple interactions

lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of WNT1 mRNA]

NCBI chr12:48,978,322...48,982,620
Ensembl chr12:48,978,322...48,982,620

G

Wnt family member 3A

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA; [lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein]

NCBI chr 1:228,006,998...228,061,271
Ensembl chr 1:228,006,998...228,061,271

G

Wnt family member 4

multiple interactions

lead nitrate affects the reaction [WNT4 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT2 mRNA]

NCBI chr 1:22,117,313...22,143,097
Ensembl chr 1:22,117,313...22,143,969

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zinc finger homeobox 3

multiple interactions

lead nitrate affects the reaction [ZFHX3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT2 mRNA]

NCBI chr16:72,782,885...73,891,930
Ensembl chr16:72,782,885...73,891,871

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zinc and ring finger 4

decreases expression

lead nitrate results in decreased expression of ZNRF4 mRNA

NCBI chr19:5,455,417...5,456,856
Ensembl chr19:5,455,417...5,456,856

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26496
chemical entity	26476
molecular entity	26458
main group molecular entity	26208
main-group coordination entity	2822
lead coordination entity	2734
lead nitrate	179
Path 2
Term	Annotations
CHEBI ontology	26496
subatomic particle	26472
composite particle	26472
hadron	26472
baryon	26472
nucleon	26472
atomic nucleus	26472
atom	26472
main group element atom	26208
p-block element atom	26208
chalcogen	25115
oxygen atom	24922
oxygen molecular entity	24922
oxide	13900
oxoanion	11009
pnictogen oxoanion	6785
nitrogen oxoanion	384
nitrate	369
nitrate salt	369
inorganic nitrate salt	369
lead nitrate	179

paths to the root