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G |
ADIPOQ |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
EXP |
2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [ADIPOQ protein results in increased secretion of Testosterone]; 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of and results in increased secretion of ADIPOQ protein |
CTD |
PMID:28284726 |
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NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646
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G |
ADIPOR1 |
adiponectin receptor 1 |
increases expression |
EXP |
2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ADIPOR1 protein |
CTD |
PMID:28284726 |
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NCBI chr10:24,907,491...24,923,540
Ensembl chr10:24,907,491...24,915,686
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G |
ADIPOR2 |
adiponectin receptor 2 |
increases expression |
EXP |
2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ADIPOR2 protein |
CTD |
PMID:28284726 |
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NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
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G |
COMT |
catechol-O-methyltransferase |
increases activity |
EXP |
2,2',4,4'-tetrabromodiphenyl ether results in increased activity of COMT protein |
CTD |
PMID:22750137 |
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NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998
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G |
CYP19A3 |
cytochrome P450 19A3 |
increases expression multiple interactions |
EXP |
2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of CYP19A1 mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP19A1 protein 2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of and results in increased activity of CYP19A1 protein; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]; Fadrozole inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of and results in increased activity of CYP19A1 protein] |
CTD |
PMID:23146758 PMID:28284726 |
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NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899
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G |
ESR1 |
estrogen receptor 1 |
increases expression |
EXP |
2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of ESR1 mRNA; 2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of ESR1 protein |
CTD |
PMID:24956591 |
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NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
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G |
ESR2 |
estrogen receptor 2 |
increases expression decreases expression |
EXP |
2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of ESR2 mRNA; 2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of ESR2 protein 2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ESR2 mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ESR2 protein |
CTD |
PMID:24956591 |
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NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565
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G |
HSD17B1 |
hydroxysteroid 17-beta dehydrogenase 1 |
increases expression |
EXP |
2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSD17B1 protein |
CTD |
PMID:21871953 |
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NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,271,548
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G |
AGO2 |
argonaute RISC catalytic component 2 |
decreases expression multiple interactions |
EXP |
tetrabromobisphenol A results in decreased expression of AGO2 protein [tetrabromobisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in decreased expression of AGO2 protein |
CTD |
PMID:31266599 |
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NCBI chr 4:2,966,794...3,012,388
Ensembl chr 4:2,919,511...3,015,334
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G |
AKT1 |
AKT serine/threonine kinase 1 |
decreases expression |
EXP |
tetrabromobisphenol A results in decreased expression of AKT1 mRNA; tetrabromobisphenol A results in decreased expression of AKT1 protein |
CTD |
PMID:35665993 |
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G |
ATP2A2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
decreases activity |
EXP |
tetrabromobisphenol A results in decreased activity of ATP2A2 protein |
CTD |
PMID:17784851 |
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NCBI chr14:31,674,659...31,744,981
Ensembl chr14:31,674,757...31,744,969
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G |
ATP2A3 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
decreases activity |
EXP |
tetrabromobisphenol A results in decreased activity of ATP2A3 protein |
CTD |
PMID:17784851 |
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NCBI chr12:49,980,488...50,014,006
Ensembl chr12:49,980,497...50,025,171
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G |
BAX |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
EXP |
tetrabromobisphenol A results in increased expression of BAX mRNA; tetrabromobisphenol A results in increased expression of BAX protein Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of BAX protein] |
CTD |
PMID:35665993 |
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NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
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G |
BCL2 |
BCL2 apoptosis regulator |
decreases expression |
EXP |
tetrabromobisphenol A results in decreased expression of BCL2 mRNA; tetrabromobisphenol A results in decreased expression of BCL2 protein |
CTD |
PMID:35665993 |
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NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
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G |
CASP3 |
caspase 3 |
increases expression multiple interactions |
EXP |
tetrabromobisphenol A results in increased expression of CASP3 mRNA; tetrabromobisphenol A results in increased expression of CASP3 protein Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP3 protein] |
CTD |
PMID:35665993 |
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NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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G |
CASP8 |
caspase 8 |
multiple interactions decreases expression |
EXP |
Melatonin inhibits the reaction [tetrabromobisphenol A results in decreased expression of CASP8 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in decreased expression of CASP8 protein] tetrabromobisphenol A results in decreased expression of CASP8 mRNA; tetrabromobisphenol A results in decreased expression of CASP8 protein |
CTD |
PMID:35665993 |
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NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
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G |
CASP9 |
caspase 9 |
multiple interactions increases expression |
EXP |
Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP9 protein] tetrabromobisphenol A results in increased expression of CASP9 mRNA; tetrabromobisphenol A results in increased expression of CASP9 protein |
CTD |
PMID:35665993 |
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NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
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G |
COX7A2L |
cytochrome c oxidase subunit 7A2 like |
increases expression multiple interactions |
EXP |
tetrabromobisphenol A results in increased expression of COX7A2L mRNA Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of COX7A2L mRNA] |
CTD |
PMID:35665993 |
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NCBI chr 3:97,951,115...97,983,309
Ensembl chr 3:97,951,114...97,983,309
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G |
DICER1 |
dicer 1, ribonuclease III |
decreases expression multiple interactions |
EXP |
tetrabromobisphenol A results in decreased expression of DICER1 mRNA; tetrabromobisphenol A results in decreased expression of DICER1 protein [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in decreased expression of DICER1 mRNA; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in decreased expression of DICER1 protein |
CTD |
PMID:31266599 |
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NCBI chr 7:116,361,630...116,436,471
Ensembl chr 7:116,365,802...116,411,224
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G |
DROSHA |
drosha ribonuclease III |
increases expression |
EXP |
tetrabromobisphenol A results in increased expression of DROSHA mRNA |
CTD |
PMID:31266599 |
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NCBI chr16:17,727,695...17,847,954
Ensembl chr16:17,565,137...17,848,162
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G |
GPER1 |
G protein-coupled estrogen receptor 1 |
decreases expression multiple interactions |
EXP |
tetrabromobisphenol A results in decreased expression of GPER1 protein [tetrabromobisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in decreased expression of GPER1 protein |
CTD |
PMID:31266599 |
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NCBI chr 3:711,427...715,982
Ensembl chr 3:712,160...715,980
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G |
LOC100623720 |
collagen alpha-1(VI) chain |
increases expression multiple interactions |
EXP |
tetrabromobisphenol A results in increased expression of COL6A1 protein 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [tetrabromobisphenol A results in increased expression of COL6A1 protein]; tetrabromobisphenol A inhibits the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased expression of COL6A1 protein] |
CTD |
PMID:31266599 |
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NCBI chr13:208,295,245...208,321,789
Ensembl chr13:208,295,451...208,313,127
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G |
MAP1LC3B |
microtubule associated protein 1 light chain 3 beta |
multiple interactions increases expression |
EXP |
[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in increased expression of MAP1LC3B protein tetrabromobisphenol A results in increased expression of MAP1LC3B protein |
CTD |
PMID:31266599 |
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NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069
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G |
MLKL |
mixed lineage kinase domain like pseudokinase |
multiple interactions increases expression |
EXP |
Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of MLKL mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of MLKL protein] tetrabromobisphenol A results in increased expression of MLKL mRNA; tetrabromobisphenol A results in increased expression of MLKL protein |
CTD |
PMID:35665993 |
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NCBI chr 6:12,923,846...12,951,176
Ensembl chr 6:12,924,894...12,951,173
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G |
PIK3CG |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma |
decreases expression |
EXP |
tetrabromobisphenol A results in decreased expression of PIK3CG mRNA; tetrabromobisphenol A results in decreased expression of PIK3CG protein |
CTD |
PMID:35665993 |
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NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099
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G |
PLIN1 |
perilipin 1 |
multiple interactions increases expression |
EXP |
[tetrabromobisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in increased expression of PLIN1 protein tetrabromobisphenol A results in increased expression of PLIN1 protein |
CTD |
PMID:31266599 |
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NCBI chr 7:55,237,517...55,250,797
Ensembl chr 7:55,236,348...55,250,797
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G |
PTEN |
phosphatase and tensin homolog |
multiple interactions increases expression |
EXP |
Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of PTEN mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of PTEN protein] tetrabromobisphenol A results in increased expression of PTEN mRNA; tetrabromobisphenol A results in increased expression of PTEN protein |
CTD |
PMID:35665993 |
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NCBI chr14:99,929,590...100,021,619
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G |
RIPK1 |
receptor interacting serine/threonine kinase 1 |
increases expression multiple interactions |
EXP |
tetrabromobisphenol A results in increased expression of RIPK1 mRNA; tetrabromobisphenol A results in increased expression of RIPK1 protein Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK1 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK1 protein] |
CTD |
PMID:35665993 |
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NCBI chr 7:1,841,143...1,880,705
Ensembl chr 7:1,841,239...1,880,699
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G |
RIPK3 |
receptor interacting serine/threonine kinase 3 |
multiple interactions increases expression |
EXP |
Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK3 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK3 protein] tetrabromobisphenol A results in increased expression of RIPK3 mRNA; tetrabromobisphenol A results in increased expression of RIPK3 protein |
CTD |
PMID:35665993 |
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NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,145...74,955,251
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G |
XPO5 |
exportin 5 |
multiple interactions decreases expression |
EXP |
[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in decreased expression of XPO5 mRNA; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in decreased expression of XPO5 protein tetrabromobisphenol A results in decreased expression of XPO5 protein |
CTD |
PMID:31266599 |
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NCBI chr 7:38,530,704...38,569,558
Ensembl chr 7:38,531,919...38,569,582
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G |
CSNK1A1 |
casein kinase 1 alpha 1 |
decreases activity affects activity |
EXP |
Ageladine A analog results in decreased activity of CSNK1A1 protein Ageladine A affects the activity of CSNK1A1 protein |
CTD |
PMID:21413800 |
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NCBI chr 2:150,612,845...150,662,431
Ensembl chr 2:150,612,077...150,662,284
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G |
LOC100739508 |
glutathione S-transferase P-like |
decreases activity multiple interactions |
EXP |
monobromobimane results in decreased activity of GSTP1 protein GSTP1 protein affects the metabolism of [monobromobimane co-treated with Glutathione] |
CTD |
PMID:14573868 |
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NCBI chr 2:5,005,498...5,009,247
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G |
CREB1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:17680988 |
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NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728
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G |
IL6 |
interleukin 6 |
decreases expression multiple interactions |
EXP |
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL6 protein N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein] |
CTD |
PMID:24105867 |
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NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
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G |
PRKACA |
protein kinase cAMP-activated catalytic subunit alpha |
multiple interactions |
EXP |
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein] |
CTD |
PMID:24105867 |
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NCBI chr 2:65,074,876...65,095,564
Ensembl chr 2:65,074,870...65,095,551
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