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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-hydroxyisovaleric acid
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Accession:CHEBI:37084 term browser browse the term
Definition:A 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency.
Synonyms:exact_synonym: 3-hydroxy-3-methylbutanoic acid
 related_synonym: 3-OH-isovaleric acid;   3-hydroxy-3-methylbutyric acid;   3-hydroxy-isovaleric acid;   3-methyl-3-hydroxybutyric acid;   Formula=C5H10O3;   HMB;   Hmb-d6;   InChI=1S/C5H10O3/c1-5(2,8)3-4(6)7/h8H,3H2,1-2H3,(H,6,7);   InChIKey=AXFYFNCPONWUHW-UHFFFAOYSA-N;   SMILES=CC(C)(O)CC(O)=O;   beta-Hydroxyisovaleric acid;   beta-hydroxy-beta-methylbutyric acid
 xref: CAS:625-08-1;   HMDB:HMDB0000754;   LIPID_MAPS_instance:LMFA01050396
 xref_mesh: MESH:C004961
 xref: PMID:12399279;   PMID:22770225;   PMID:9523856;   Reaxys:1743952;   Wikipedia:Beta-Hydroxy_beta-methylbutyric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:82957


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3-hydroxyisovaleric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Dexamethasone co-treated with beta-hydroxyisovaleric acid] results in increased phosphorylation of AKT1 protein CTD PMID:24124592 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Fbxo32 F-box protein 32 increases expression
multiple interactions 		EXP beta-hydroxyisovaleric acid results in increased expression of FBXO32 mRNA
beta-hydroxyisovaleric acid inhibits the reaction [Dexamethasone results in increased expression of FBXO32 mRNA] 		CTD PMID:24124592 NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491 		JBrowse link
G Usp16 ubiquitin specific peptidase 16 increases expression EXP beta-hydroxyisovaleric acid results in increased expression of USP16 mRNA CTD PMID:24124592 NCBI chr11:40,166,651...40,196,792
Ensembl chr11:40,167,692...40,196,823 		JBrowse link
G Usp2 ubiquitin specific peptidase 2 increases expression EXP beta-hydroxyisovaleric acid results in increased expression of USP2 mRNA CTD PMID:24124592 NCBI chr 8:53,308,264...53,336,800
Ensembl chr 8:53,308,303...53,336,794 		JBrowse link
G Usp28 ubiquitin specific peptidase 28 increases expression EXP beta-hydroxyisovaleric acid results in increased expression of USP28 mRNA CTD PMID:24124592 NCBI chr 8:58,222,258...58,282,711
Ensembl chr 8:58,222,220...58,282,750 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20871
    role 20829
      biological role 20827
        biochemical role 20274
          metabolite 20255
            eukaryotic metabolite 19969
              plant metabolite 18270
                isovaleric acid 1746
                  3-hydroxyisovaleric acid 5
                    3-hydroxyisovaleryl-CoA 0
                    3-hydroxyisovalerylcarnitine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20871
    subatomic particle 20869
      composite particle 20869
        hadron 20869
          baryon 20869
            nucleon 20869
              atomic nucleus 20869
                atom 20869
                  main group element atom 20792
                    p-block element atom 20792
                      carbon group element atom 20725
                        carbon atom 20721
                          organic molecular entity 20721
                            heteroorganic entity 20226
                              organochalcogen compound 19911
                                organooxygen compound 19814
                                  carbon oxoacid 19160
                                    carboxylic acid 19157
                                      monocarboxylic acid 18307
                                        fatty acid 17006
                                          short-chain fatty acid 16028
                                            fatty acid 4:0 8295
                                              butyric acid 6783
                                                methylbutyric acid 2523
                                                  isovaleric acid 1746
                                                    3-hydroxyisovaleric acid 5
                                                      3-hydroxyisovaleryl-CoA 0
                                                      3-hydroxyisovalerylcarnitine 0
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