3-hydroxyisovaleric acid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	3-hydroxyisovaleric acid	go back to main search page
Accession:	CHEBI:37084	browse the term
Definition:	A 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency.
Synonyms:	related_synonym:	3-Hydroxy-3-methylbutanoic acid; 3-OH-isovaleric acid; 3-hydroxy-3-methylbutyric acid; 3-hydroxy-isovaleric acid; 3-methyl-3-hydroxybutyric acid; Formula=C5H10O3; HMB; Hmb-d6; InChI=1S/C5H10O3/c1-5(2,8)3-4(6)7/h8H,3H2,1-2H3,(H,6,7); InChIKey=AXFYFNCPONWUHW-UHFFFAOYSA-N; SMILES=CC(C)(O)CC(O)=O; beta-Hydroxyisovaleric acid; beta-hydroxy-beta-methylbutyric acid
	xref:	Beilstein:1743952; CAS:625-08-1; HMDB:HMDB0000754; LIPID_MAPS_instance:LMFA01050396
	xref_mesh:	MESH:C004961
	xref:	PMID:12399279; PMID:22770225; PMID:9523856; Reaxys:1743952; Wikipedia:Beta-Hydroxy_beta-methylbutyric_acid
	cyclic_relationship:	is_conjugate_acid_of CHEBI:82957

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Rat (5) Mouse (5) Human (5) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) All
Genes (5)

3-hydroxyisovaleric acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

[Dexamethasone co-treated with beta-hydroxyisovaleric acid] results in increased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

F-box protein 32

increases expression
multiple interactions

beta-hydroxyisovaleric acid results in increased expression of FBXO32 mRNA
beta-hydroxyisovaleric acid inhibits the reaction [Dexamethasone results in increased expression of FBXO32 mRNA]

NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436

G

ubiquitin specific peptidase 16

increases expression

beta-hydroxyisovaleric acid results in increased expression of USP16 mRNA

NCBI chr11:26,681,359...26,711,313
Ensembl chr11:26,681,414...26,710,539

G

ubiquitin specific peptidase 2

increases expression

beta-hydroxyisovaleric acid results in increased expression of USP2 mRNA

NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331

G

ubiquitin specific peptidase 28

increases expression

beta-hydroxyisovaleric acid results in increased expression of USP28 mRNA

NCBI chr 8:49,325,766...49,386,229
Ensembl chr 8:49,325,867...49,386,229

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19812
role	19761
biological role	19761
biochemical role	19381
metabolite	19356
eukaryotic metabolite	19044
plant metabolite	17455
isovaleric acid	1533
3-hydroxyisovaleric acid	5
3-hydroxyisovaleryl-CoA	0
3-hydroxyisovalerylcarnitine	0
Path 2
Term	Annotations
CHEBI ontology	19812
subatomic particle	19811
composite particle	19811
hadron	19811
baryon	19811
nucleon	19811
atomic nucleus	19811
atom	19811
main group element atom	19708
p-block element atom	19708
carbon group element atom	19630
carbon atom	19620
organic molecular entity	19620
organic group	18728
organic divalent group	18719
organodiyl group	18719
carbonyl group	18667
carbonyl compound	18667
carboxylic acid	18364
monocarboxylic acid	17632
fatty acid	16012
short-chain fatty acid	15700
fatty acid 4:0	7901
butyric acid	6271
methylbutyric acid	2306
isovaleric acid	1533
3-hydroxyisovaleric acid	5
3-hydroxyisovaleryl-CoA	0
3-hydroxyisovalerylcarnitine	0

paths to the root