Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-hydroxyisovaleric acid
go back to main search page
Accession:CHEBI:37084 term browser browse the term
Definition:A 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency.
Synonyms:related_synonym: 3-Hydroxy-3-methylbutanoic acid;   3-OH-isovaleric acid;   3-hydroxy-3-methylbutyric acid;   3-hydroxy-isovaleric acid;   3-methyl-3-hydroxybutyric acid;   Formula=C5H10O3;   HMB;   Hmb-d6;   InChI=1S/C5H10O3/c1-5(2,8)3-4(6)7/h8H,3H2,1-2H3,(H,6,7);   InChIKey=AXFYFNCPONWUHW-UHFFFAOYSA-N;   SMILES=CC(C)(O)CC(O)=O;   beta-Hydroxyisovaleric acid;   beta-hydroxy-beta-methylbutyric acid
 xref: Beilstein:1743952;   CAS:625-08-1;   HMDB:HMDB0000754;   LIPID_MAPS_instance:LMFA01050396
 xref_mesh: MESH:C004961
 xref: PMID:12399279;   PMID:22770225;   PMID:9523856;   Reaxys:1743952;   Wikipedia:Beta-Hydroxy_beta-methylbutyric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:82957

show annotations for term's descendants           Sort by:
 
3-hydroxyisovaleric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Dexamethasone co-treated with beta-hydroxyisovaleric acid] results in increased phosphorylation of AKT1 protein CTD PMID:24124592 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Fbxo32 F-box protein 32 increases expression
multiple interactions		 EXP beta-hydroxyisovaleric acid results in increased expression of FBXO32 mRNA
beta-hydroxyisovaleric acid inhibits the reaction [Dexamethasone results in increased expression of FBXO32 mRNA]		 CTD PMID:24124592 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268 		JBrowse link
G Usp16 ubiquitin specific peptidase 16 increases expression EXP beta-hydroxyisovaleric acid results in increased expression of USP16 mRNA CTD PMID:24124592 NCBI chr11:27,101,213...27,130,345
Ensembl chr11:27,101,227...27,130,341 		JBrowse link
G Usp2 ubiquitin specific peptidase 2 increases expression EXP beta-hydroxyisovaleric acid results in increased expression of USP2 mRNA CTD PMID:24124592 NCBI chr 8:48,403,985...48,432,525
Ensembl chr 8:48,406,260...48,430,885 		JBrowse link
G Usp28 ubiquitin specific peptidase 28 increases expression EXP beta-hydroxyisovaleric acid results in increased expression of USP28 mRNA CTD PMID:24124592 NCBI chr 8:53,295,188...53,355,572
Ensembl chr 8:53,295,222...53,355,572 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            eukaryotic metabolite 18908
              plant metabolite 17360
                isovaleric acid 100
                  3-hydroxyisovaleric acid 5
                    3-hydroxyisovaleryl-CoA 0
                    3-hydroxyisovalerylcarnitine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          fatty acid 15845
                                            short-chain fatty acid 15500
                                              fatty acid 4:0 7011
                                                butyric acid 5292
                                                  methylbutyric acid 980
                                                    isovaleric acid 100
                                                      3-hydroxyisovaleric acid 5
                                                        3-hydroxyisovaleryl-CoA 0
                                                        3-hydroxyisovalerylcarnitine 0
paths to the root

Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.