CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 3-hydroxyisovaleric acid
Accession: CHEBI:37084
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Definition: A 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency.
Synonyms: exact_synonym: 3-hydroxy-3-methylbutanoic acid
related_synonym: 3-OH-isovaleric acid; 3-hydroxy-3-methylbutyric acid; 3-hydroxy-isovaleric acid; 3-methyl-3-hydroxybutyric acid; Formula=C5H10O3; HMB; Hmb-d6; InChI=1S/C5H10O3/c1-5(2,8)3-4(6)7/h8H,3H2,1-2H3,(H,6,7); InChIKey=AXFYFNCPONWUHW-UHFFFAOYSA-N; SMILES=CC(C)(O)CC(O)=O; beta-Hydroxyisovaleric acid; beta-hydroxy-beta-methylbutyric acid
xref: CAS:625-08-1; HMDB:HMDB0000754; LIPID_MAPS_instance:LMFA01050396
xref_mesh: MESH:C004961
xref: PMID:12399279; PMID:22770225; PMID:9523856; Reaxys:1743952; Wikipedia:Beta-Hydroxy_beta-methylbutyric_acid
cyclic_relationship: is_conjugate_acid_of CHEBI:82957
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
EXP
[Dexamethasone co-treated with beta-hydroxyisovaleric acid] results in increased phosphorylation of AKT1 protein
CTD
PMID:24124592
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
G
Fbxo32
F-box protein 32
increases expression multiple interactions
EXP
beta-hydroxyisovaleric acid results in increased expression of FBXO32 mRNA beta-hydroxyisovaleric acid inhibits the reaction [Dexamethasone results in increased expression of FBXO32 mRNA]
CTD
PMID:24124592
NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491
G
Usp16
ubiquitin specific peptidase 16
increases expression
EXP
beta-hydroxyisovaleric acid results in increased expression of USP16 mRNA
CTD
PMID:24124592
NCBI chr11:40,166,651...40,196,792
Ensembl chr11:40,167,692...40,196,823
G
Usp2
ubiquitin specific peptidase 2
increases expression
EXP
beta-hydroxyisovaleric acid results in increased expression of USP2 mRNA
CTD
PMID:24124592
NCBI chr 8:53,308,264...53,336,800
Ensembl chr 8:53,308,303...53,336,794
G
Usp28
ubiquitin specific peptidase 28
increases expression
EXP
beta-hydroxyisovaleric acid results in increased expression of USP28 mRNA
CTD
PMID:24124592
NCBI chr 8:58,222,258...58,282,711
Ensembl chr 8:58,222,220...58,282,750
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