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G |
Eif4e |
eukaryotic translation initiation factor 4E |
multiple interactions |
ISO |
7-methylguanosine triphosphate inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]; 7-methylguanosine triphosphate inhibits the reaction [RNA Caps binds to EIF4E protein] |
CTD |
PMID:27592390 |
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NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions affects binding |
ISO |
1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one promotes the reaction [EIF4EBP1 protein binds to 7-methylguanosine triphosphate]; Sirolimus promotes the reaction [EIF4EBP1 protein binds to 7-methylguanosine triphosphate] |
CTD |
PMID:25940091 |
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NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
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G |
Eif4g1 |
eukaryotic translation initiation factor 4 gamma, 1 |
multiple interactions affects binding |
ISO |
1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EIF4G1 protein binds to 7-methylguanosine triphosphate]; Sirolimus inhibits the reaction [EIF4G1 protein binds to 7-methylguanosine triphosphate] |
CTD |
PMID:25940091 |
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NCBI chr11:83,907,659...83,927,683
Ensembl chr11:83,908,109...83,926,524
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G |
Cd80 |
Cd80 molecule |
increases expression |
ISO |
adenosine 5'-O-(3-thiotriphosphate) results in increased expression of CD80 protein |
CTD |
PMID:15944274 |
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NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
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G |
Cd86 |
CD86 molecule |
increases expression |
ISO |
adenosine 5'-O-(3-thiotriphosphate) results in increased expression of CD86 protein |
CTD |
PMID:15944274 |
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NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
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G |
Il10 |
interleukin 10 |
decreases expression |
ISO |
adenosine 5'-O-(3-thiotriphosphate) results in decreased expression of IL10 protein |
CTD |
PMID:15944274 |
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NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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G |
Il12b |
interleukin 12B |
increases expression |
ISO |
adenosine 5'-O-(3-thiotriphosphate) results in increased expression of IL12B protein |
CTD |
PMID:15944274 |
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NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
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G |
Il1b |
interleukin 1 beta |
increases expression |
ISO |
adenosine 5'-O-(3-thiotriphosphate) results in increased expression of IL1B protein |
CTD |
PMID:15944274 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
LOC102552569 |
P2Y purinoceptor 11-like |
multiple interactions |
ISO |
[adenosine 5'-O-(3-thiotriphosphate) binds to and results in increased activity of P2RY11 protein] which results in increased expression of CXCL8 protein; adenosine 5'-O-(3-thiotriphosphate) binds to and results in increased activity of P2RY11 protein |
CTD |
PMID:19815812 |
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NCBI chr 8:21,910,636...21,911,499
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G |
P2rx7 |
purinergic receptor P2X 7 |
affects response to substance |
ISO |
P2RX7 protein affects the susceptibility to adenosine 5'-O-(3-thiotriphosphate) |
CTD |
PMID:12873706 |
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NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
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G |
Ptgdr |
prostaglandin D2 receptor |
multiple interactions |
ISO |
adenosine 5'-O-(3-thiotriphosphate) inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] |
CTD |
PMID:9579725 |
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NCBI chr15:19,195,606...19,196,508
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G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
increases activity multiple interactions |
EXP |
adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein Capsaicin promotes the reaction [adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein] |
CTD |
PMID:11140687 |
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NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
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G |
Abca8 |
ATP binding cassette subfamily A member 8 |
multiple interactions |
ISO |
Adenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] |
CTD |
PMID:12379217 |
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NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions |
ISO EXP |
Adenosine Triphosphate promotes the reaction [ABCB11 protein results in increased uptake of fexofenadine] |
CTD |
PMID:18245269 |
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NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions increases hydrolysis |
ISO EXP |
[Cobalt results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; [Magnesium results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; [Manganese results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; ABCB1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; crizotinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram affects the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; lapatinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate] [Rifampin metabolite results in decreased activity of ABCB1A protein] which results in decreased abundance of Adenosine Triphosphate |
CTD |
PMID:2900677 PMID:14978246 PMID:18829547 PMID:18955043 PMID:22233293 PMID:23685082 |
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NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions affects activity increases hydrolysis affects binding |
ISO |
[Adenosine Triphosphate affects the activity of ABCC1 protein] which results in increased transport of Acetaminophen metabolite; ABCC1 protein binds to and results in increased degradation of Adenosine Triphosphate; ABCC1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; ABCC1 protein mutant form binds to and results in increased hydrolysis of Adenosine Triphosphate; Adenosine Triphosphate binds to and affects the folding of ABCC1 protein; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4]; daidzein promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Resveratrol promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] Daunorubicin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Vanadates inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] Adenosine Triphosphate binds to ABCC1 protein |
CTD |
PMID:10856430 PMID:11278000 PMID:14978246 PMID:15245331 PMID:15355964 PMID:15459206 PMID:15737336 PMID:15838832 PMID:16156793 PMID:18336795 PMID:18955043 PMID:32472168 |
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NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions affects activity affects metabolic processing |
EXP ISO |
Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased secretion of Fluo-3]; Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased transport of temocaprilat] Adenosine Triphosphate affects the activity of ABCC2 protein [Adenosine Triphosphate affects the activity of ABCC2 protein] which results in increased transport of Acetaminophen metabolite; [Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; Adenosine Triphosphate affects the reaction [ABCC2 protein results in increased transport of Mercury]; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide] ABCC2 protein affects the metabolism of Adenosine Triphosphate Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased transport of S-1,2-dichlorovinyl-N-acetylcysteine] |
CTD |
PMID:9067317 PMID:9794919 PMID:20060011 PMID:22027652 PMID:24039982 PMID:32003934 PMID:32472168 |
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NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
Adenosine Triphosphate promotes the reaction [ABCC3 protein affects the transport of fexofenadine] |
CTD |
PMID:18245269 |
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NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions affects activity increases hydrolysis |
ISO |
[Adenosine Triphosphate affects the activity of ABCC4 protein] which results in increased transport of Acetaminophen metabolite; ABCC4 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; daidzein promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; hesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin affects the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]; Resveratrol promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]] |
CTD |
PMID:14978246 PMID:16156793 PMID:32472168 |
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NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
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G |
Abcc6 |
ATP binding cassette subfamily C member 6 |
affects binding |
ISO |
Adenosine Triphosphate binds to ABCC6 protein |
CTD |
PMID:11880368 |
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NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
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G |
Abcc8 |
ATP binding cassette subfamily C member 8 |
multiple interactions |
EXP |
Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]] |
CTD |
PMID:19095654 |
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NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287
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G |
Abcc9 |
ATP binding cassette subfamily C member 9 |
multiple interactions |
EXP ISO |
Adenosine Triphosphate results in decreased activity of [KCNJ8 protein binds to ABCC9 protein] Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]] |
CTD |
PMID:11390963 PMID:28842488 |
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NCBI chr 4:176,806,098...176,928,540
Ensembl chr 4:176,805,431...176,922,424
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
increases hydrolysis multiple interactions |
ISO |
ABCG2 protein results in increased hydrolysis of Adenosine Triphosphate [Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate; Lapatinib promotes the reaction [ABCG2 protein results in increased hydrolysis of Adenosine Triphosphate]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate] |
CTD |
PMID:18829547 PMID:32003934 |
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NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
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G |
Abl1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
multiple interactions |
ISO |
[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] |
CTD |
PMID:19366808 |
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NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
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G |
Adcyap1 |
adenylate cyclase activating polypeptide 1 |
increases secretion |
EXP |
ADCYAP1 protein results in increased secretion of Adenosine Triphosphate |
CTD |
PMID:18563302 |
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NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
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G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions decreases expression |
EXP |
Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein; ARRB2 protein affects the reaction [Adenosine Triphosphate results in decreased activity of AGTR1A protein]; CABIN1 protein inhibits the reaction [Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein]; Cyclosporine inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A mRNA]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A mRNA]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A protein] |
CTD |
PMID:21464294 |
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NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
Adenosine Triphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein] |
CTD |
PMID:1848756 |
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NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases activity multiple interactions |
ISO |
Adenosine Triphosphate results in decreased activity of AKT1 protein Alcohols inhibits the reaction [Adenosine Triphosphate results in decreased activity of AKT1 protein] |
CTD |
PMID:24300283 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Aldh5a1 |
aldehyde dehydrogenase 5 family, member A1 |
increases abundance |
ISO |
ALDH5A1 gene mutant form results in increased abundance of Adenosine Triphosphate |
CTD |
PMID:29031482 |
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NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413
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G |
Alk |
ALK receptor tyrosine kinase |
affects binding multiple interactions |
ISO |
ALK protein binds to Adenosine Triphosphate [ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]] which results in decreased susceptibility to crizotinib; ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate] |
CTD |
PMID:22072639 |
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NCBI chr 6:22,696,415...23,203,791
Ensembl chr 6:22,696,397...23,203,775
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
increases response to substance multiple interactions |
ISO |
ALPL gene mutant form results in increased susceptibility to Adenosine Triphosphate ALPL gene mutant form promotes the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA] |
CTD |
PMID:27466191 |
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NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
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G |
Anxa1 |
annexin A1 |
multiple interactions |
EXP |
[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein; arsenite affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; Cadmium affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; chromium hexavalent ion affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; Lead affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein] |
CTD |
PMID:20655937 |
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NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
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G |
App |
amyloid beta precursor protein |
multiple interactions increases secretion |
ISO |
Adenosine Triphosphate inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]; Adenosine Triphosphate inhibits the reaction [Rotenone results in decreased secretion of APP protein modified form]; Rotenone inhibits the reaction [Adenosine Triphosphate results in increased secretion of APP protein modified form]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased secretion of APP protein modified form] |
CTD |
PMID:22906069 |
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NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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G |
Arrb2 |
arrestin, beta 2 |
multiple interactions |
EXP |
Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]]; ARRB2 protein affects the reaction [Adenosine Triphosphate results in decreased activity of AGTR1A protein] |
CTD |
PMID:21464294 |
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NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
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G |
Asic1 |
acid sensing ion channel subunit 1 |
multiple interactions |
EXP |
[Acids binds to and affects the activity of ASIC1 protein] which results in increased secretion of Adenosine Triphosphate |
CTD |
PMID:19860742 |
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NCBI chr 7:141,324,714...141,354,937
Ensembl chr 7:141,326,321...141,354,937
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G |
Asic2 |
acid sensing ion channel subunit 2 |
multiple interactions |
EXP |
[Acids binds to and affects the activity of ASIC2 protein] which results in increased secretion of Adenosine Triphosphate |
CTD |
PMID:19860742 |
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NCBI chr10:68,247,800...69,347,223
Ensembl chr10:68,248,655...68,517,564
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G |
Asic3 |
acid sensing ion channel subunit 3 |
multiple interactions |
EXP |
[Acids binds to and affects the activity of ASIC3 protein] which results in increased secretion of Adenosine Triphosphate |
CTD |
PMID:19860742 |
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NCBI chr 4:7,287,868...7,293,295
Ensembl chr 4:7,288,855...7,292,901
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G |
Atp7a |
ATPase copper transporting alpha |
multiple interactions |
ISO |
[Copper co-treated with Adenosine Triphosphate] results in increased phosphorylation of ATP7A protein |
CTD |
PMID:20964302 |
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NCBI chr X:77,076,085...77,193,644
Ensembl chr X:77,076,106...77,193,644
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G |
Atp7b |
ATPase copper transporting beta |
multiple interactions increases phosphorylation |
ISO |
[Copper co-treated with Adenosine Triphosphate] results in increased phosphorylation of ATP7B protein Adenosine Triphosphate results in increased phosphorylation of ATP7B protein |
CTD |
PMID:19405516 PMID:20964302 |
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NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
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G |
Atp8b1 |
ATPase phospholipid transporting 8B1 |
increases hydrolysis |
EXP |
ATP8B1 protein results in increased hydrolysis of Adenosine Triphosphate |
CTD |
PMID:11584374 |
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NCBI chr18:60,013,388...60,152,920
Ensembl chr18:60,013,382...60,095,354
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G |
Avp |
arginine vasopressin |
multiple interactions increases secretion |
EXP |
Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of AVP protein]; bisindolylmaleimide I inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of AVP protein] |
CTD |
PMID:11102496 |
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NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[Adenosine Triphosphate binds to P2RY11 protein] which results in decreased expression of BCL2 protein |
CTD |
PMID:21503959 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcr |
BCR activator of RhoGEF and GTPase |
multiple interactions |
ISO |
[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] |
CTD |
PMID:19366808 |
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NCBI chr20:14,421,250...14,546,406
Ensembl chr20:14,421,141...14,545,772
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G |
Cabin1 |
calcineurin binding protein 1 |
multiple interactions |
EXP |
CABIN1 protein inhibits the reaction [Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein] |
CTD |
PMID:21464294 |
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NCBI chr20:13,836,032...13,963,003
Ensembl chr20:13,836,030...13,963,003
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G |
Calca |
calcitonin-related polypeptide alpha |
increases secretion multiple interactions |
EXP |
Adenosine Triphosphate results in increased secretion of CALCA protein Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]; Suramin inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]] |
CTD |
PMID:12044622 |
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NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
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G |
Casp1 |
caspase 1 |
increases activity multiple interactions |
EXP ISO |
Adenosine Triphosphate results in increased activity of CASP1 mRNA; Adenosine Triphosphate results in increased activity of CASP1 protein [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP1 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein; fraxinellone inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP1 mRNA]; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP1 protein] [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [PML protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein; Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP1 protein]; Arsenic Trioxide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein] |
CTD |
PMID:18604214 PMID:19130485 PMID:21832250 PMID:23430110 PMID:24149798 PMID:25288807 PMID:25448682 PMID:26431797 PMID:26586371 |
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NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
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G |
Casp3 |
caspase 3 |
increases expression multiple interactions |
ISO |
Adenosine Triphosphate results in increased expression of CASP3 Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of CASP3] |
CTD |
PMID:19448140 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp4 |
caspase 4 |
multiple interactions |
ISO |
[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP4 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP4 protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP4 mRNA]; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP4 protein] Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP4 protein] |
CTD |
PMID:24149798 PMID:25288807 |
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NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
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G |
Cat |
catalase |
increases expression |
ISO |
Adenosine Triphosphate results in increased expression of CAT mRNA |
CTD |
PMID:22129738 |
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NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
increases secretion multiple interactions |
ISO |
Adenosine Triphosphate results in increased secretion of CCL3 protein azetidine inhibits the reaction [Adenosine Triphosphate results in increased secretion of CCL3 protein] |
CTD |
PMID:26522449 |
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NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions |
ISO |
3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [Adenosine Triphosphate promotes the reaction [CFTR protein results in increased export of Chlorides]]; [Phosphatidylinositol 4,5-Diphosphate co-treated with Adenosine Triphosphate] results in increased activity of CFTR protein; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Adenosine Triphosphate binds to and results in increased activity of CFTR protein; Adenosine Triphosphate promotes the reaction [CFTR protein results in increased export of Chlorides] |
CTD |
PMID:14710196 PMID:15623556 PMID:17178710 PMID:20675434 |
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NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
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G |
Chordc1 |
cysteine and histidine rich domain containing 1 |
multiple interactions |
ISO |
Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to PPP5C protein]; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to SUGT1 protein] Adenosine Triphosphate binds to and affects the folding of CHORDC1 protein; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to CHORDC1 protein]; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein] |
CTD |
PMID:23184943 |
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NCBI chr 8:17,421,552...17,445,513
Ensembl chr 8:17,421,557...17,446,165
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G |
Comt |
catechol-O-methyltransferase |
multiple interactions |
ISO |
[Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate |
CTD |
PMID:14975680 |
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NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
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G |
Cpt2 |
carnitine palmitoyltransferase 2 |
multiple interactions |
ISO |
[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate; Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate] |
CTD |
PMID:21816645 |
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NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
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G |
Crkl |
CRK like proto-oncogene, adaptor protein |
multiple interactions |
ISO |
[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; [BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein]; sorafenib inhibits the reaction [[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] |
CTD |
PMID:19366808 |
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NCBI chr11:87,338,606...87,356,644
Ensembl chr11:87,778,312...87,815,043
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G |
Csnk2a1 |
casein kinase 2 alpha 1 |
multiple interactions affects binding |
ISO |
silmitasertib inhibits the reaction [Adenosine Triphosphate binds to [CSNK2A1 protein binds to CSNK2A1 protein binds to CSNK2B protein binds to CSNK2B protein]] |
CTD |
PMID:21174434 |
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NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
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G |
Csnk2b |
casein kinase 2 beta |
multiple interactions affects binding |
ISO |
silmitasertib inhibits the reaction [Adenosine Triphosphate binds to [CSNK2A1 protein binds to CSNK2A1 protein binds to CSNK2B protein binds to CSNK2B protein]] |
CTD |
PMID:21174434 |
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NCBI chr20:5,108,692...5,113,675
Ensembl chr20:5,106,890...5,113,112
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G |
Cstb |
cystatin B |
multiple interactions |
ISO |
Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP1 protein]; Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP4 protein] |
CTD |
PMID:25288807 |
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NCBI chr20:10,966,357...10,968,399
Ensembl chr20:10,966,331...10,968,432
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G |
Ctsb |
cathepsin B |
increases activity multiple interactions |
ISO |
Adenosine Triphosphate results in increased activity of CTSB protein azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of CTSB protein] |
CTD |
PMID:26522449 |
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NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases secretion multiple interactions |
ISO |
Adenosine Triphosphate results in increased secretion of CXCL2 protein azetidine inhibits the reaction [Adenosine Triphosphate results in increased secretion of CXCL2 protein] |
CTD |
PMID:26522449 |
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NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
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G |
Dmd |
dystrophin |
increases secretion multiple interactions |
ISO |
DMD gene mutant form results in increased secretion of Adenosine Triphosphate Nifedipine inhibits the reaction [DMD gene mutant form results in increased secretion of Adenosine Triphosphate] |
CTD |
PMID:24349043 |
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NCBI chr X:51,149,358...53,519,271
Ensembl chr X:51,286,737...53,519,259
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions increases phosphorylation |
ISO |
sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of EGFR protein] |
CTD |
PMID:26104857 |
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NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
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G |
Egr1 |
early growth response 1 |
multiple interactions increases expression |
EXP |
Iodoacetates inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA]; Potassium Cyanide inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA] |
CTD |
PMID:10723097 |
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NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
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G |
Enpp2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
multiple interactions |
ISO |
Adenosine Triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein] |
CTD |
PMID:26072274 |
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NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
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G |
Enpp7 |
ectonucleotide pyrophosphatase/phosphodiesterase 7 |
decreases activity |
ISO |
Adenosine Triphosphate results in decreased activity of ENPP7 protein |
CTD |
PMID:12885774 |
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NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483
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G |
Ercc6 |
ERCC excision repair 6, chromatin remodeling factor |
decreases abundance multiple interactions |
ISO |
ERCC6 gene mutant form results in decreased abundance of Adenosine Triphosphate nicotinamide-beta-riboside inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Adenosine Triphosphate] |
CTD |
PMID:25440059 |
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NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610
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G |
F2 |
coagulation factor II |
multiple interactions increases transport increases abundance increases secretion |
ISO |
calmidazolium affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]; Fendiline affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]; Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate]; resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate] F2 protein results in increased transport of Adenosine Triphosphate STXBP2 protein affects the reaction [F2 protein results in increased transport of Adenosine Triphosphate] |
CTD |
PMID:2030746 PMID:15342215 PMID:30696774 |
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NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
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G |
Fasn |
fatty acid synthase |
multiple interactions decreases abundance |
ISO |
FASN protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]; Protein Kinase Inhibitors inhibits the reaction [FASN protein results in decreased abundance of Adenosine Triphosphate] |
CTD |
PMID:26670611 |
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NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP ISO |
Adenosine Triphosphate results in increased expression of FOS mRNA ALPL gene mutant form promotes the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA] [Phenylephrine co-treated with Adenosine Triphosphate] results in increased expression of FOS mRNA; Glucose affects the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Iodoacetates inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Potassium Cyanide inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA] |
CTD |
PMID:10723097 PMID:19463813 PMID:27466191 |
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NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Fscn1 |
fascin actin-bundling protein 1 |
increases expression multiple interactions |
ISO |
Adenosine Triphosphate results in increased expression of FSCN1 mRNA Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of FSCN1 mRNA] |
CTD |
PMID:29733962 |
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NCBI chr12:13,655,459...13,668,595
Ensembl chr12:13,656,554...13,668,515
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
ISO |
Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog] |
CTD |
PMID:15788719 |
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NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
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G |
Gh1 |
growth hormone 1 |
multiple interactions increases secretion |
ISO EXP |
oxophenylarsine inhibits the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; Phosphatidylinositol 4,5-Diphosphate affects the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein] NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]] |
CTD |
PMID:12471042 |
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NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
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G |
Gja1 |
gap junction protein, alpha 1 |
increases export |
ISO |
GJA1 protein mutant form results in increased export of Adenosine Triphosphate; GJA1 protein results in increased export of Adenosine Triphosphate |
CTD |
PMID:17687502 |
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NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
[GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] |
CTD |
PMID:11196146 |
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NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
Adenosine Triphosphate inhibits the reaction [protoporphyrin IX results in decreased activity of HIF1A protein] |
CTD |
PMID:23624237 |
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NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Hmgb1 |
high mobility group box 1 |
affects chemical synthesis multiple interactions |
ISO |
HMGB1 protein affects the chemical synthesis of Adenosine Triphosphate Adenosine Triphosphate promotes the reaction [fullerene C60 results in increased secretion of HMGB1 protein]; Adenosine Triphosphate promotes the reaction [graphene oxide results in increased secretion of HMGB1 protein]; Adenosine Triphosphate promotes the reaction [Nanotubes, Carbon results in increased secretion of HMGB1 protein] |
CTD |
PMID:21641551 PMID:31504961 |
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NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
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G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
multiple interactions |
ISO |
Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]] |
CTD |
PMID:23184943 |
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NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA]; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein] |
CTD |
PMID:24149798 |
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NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
affects chemical synthesis |
ISO |
HSPB1 protein affects the chemical synthesis of Adenosine Triphosphate |
CTD |
PMID:21641551 |
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NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
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G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
multiple interactions increases expression |
EXP |
bisindolylmaleimide I inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; chelerythrine inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; Neomycin inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; resveratrol inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; tricyclodecane-9-yl-xanthogenate inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein] |
CTD |
PMID:16178011 |
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NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
Adenosine Triphosphate inhibits the reaction [Fructose results in increased expression of ICAM1 protein] |
CTD |
PMID:18508964 |
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NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone] |
CTD |
PMID:14623498 |
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NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] |
CTD |
PMID:17707769 |
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NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
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G |
Il18 |
interleukin 18 |
multiple interactions increases secretion |
ISO |
[Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein] Adenosine Triphosphate results in increased secretion of IL18 protein 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA; Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein] |
CTD |
PMID:17404311 PMID:24149798 PMID:26431797 PMID:27311643 |
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NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1A protein]; (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1A protein; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] |
CTD |
PMID:26068648 |
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NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases secretion decreases abundance |
EXP ISO |
Enzyme Inhibitors inhibits the reaction [IL1B protein results in decreased abundance of Adenosine Triphosphate]; IL1B protein inhibits the reaction [Adenosine Triphosphate results in increased secretion of INS1 protein]; Quercetin inhibits the reaction [IL1B protein inhibits the reaction [Adenosine Triphosphate results in increased secretion of INS1 protein]] Adenosine Triphosphate results in increased secretion of IL1B protein (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased activity of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; arsenic trioxide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; Okadaic Acid inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; PML protein promotes the reaction [[resiquimod co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]] [Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; [Tetradecanoylphorbol Acetate co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein; Apigenin inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; flavone analog inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein]; MitoTEMPO inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein] |
CTD |
PMID:10365824 PMID:14623498 PMID:17404311 PMID:18604214 PMID:19130485 PMID:22221676 PMID:23430110 PMID:24149798 PMID:24158569 PMID:24685903 PMID:26068648 PMID:26086368 PMID:26431797 PMID:26586371 PMID:26968431 PMID:27311643 PMID:29960001 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
ISO EXP |
Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; NF157 compound inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein] Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]; coomassie Brilliant Blue inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]; resveratrol inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]; SB 203580 inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]] azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; MRS 2211 inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein] |
CTD |
PMID:17707769 PMID:24793913 PMID:24849676 PMID:25348860 PMID:26104857 PMID:26522449 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
[ammonium ferrous sulfate results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate; [chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate; INS protein inhibits the reaction [Acetaminophen results in decreased abundance of Adenosine Triphosphate]; Mannose inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate]; Phloretin inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate] |
CTD |
PMID:17965850 PMID:26739624 |
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NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
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G |
Itgb1bp2 |
integrin subunit beta 1 binding protein 2 |
multiple interactions |
ISO |
Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to PPP5C protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]] Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to ITGB1BP2 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]] |
CTD |
PMID:23184943 |
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NCBI chr X:71,342,770...71,347,623
Ensembl chr X:71,342,775...71,347,619
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of JUN protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of JUN protein] |
CTD |
PMID:24149798 |
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NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Adenosine Triphosphate deficiency results in decreased activity of KCNH2 protein |
CTD |
PMID:12531891 |
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NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
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G |
Kcnj11 |
potassium inwardly-rectifying channel, subfamily J, member 11 |
multiple interactions decreases response to substance |
ISO |
Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]] KCNJ11 protein mutant form results in decreased susceptibility to Adenosine Triphosphate |
CTD |
PMID:11390963 PMID:28842488 |
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NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
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G |
Kcnj15 |
potassium inwardly-rectifying channel, subfamily J, member 15 |
increases activity |
ISO |
Adenosine Triphosphate results in increased activity of KCNJ15 protein |
CTD |
PMID:15328350 |
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NCBI chr11:35,545,185...35,588,517
Ensembl chr11:35,568,182...35,585,390
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G |
Kcnj8 |
potassium inwardly-rectifying channel, subfamily J, member 8 |
multiple interactions decreases response to substance |
EXP |
Adenosine Triphosphate results in decreased activity of [KCNJ8 protein binds to ABCC9 protein] KCNJ8 protein mutant form results in decreased susceptibility to Adenosine Triphosphate |
CTD |
PMID:28842488 |
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NCBI chr 4:176,783,287...176,789,143
Ensembl chr 4:176,782,498...176,789,304
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G |
Khk |
ketohexokinase |
multiple interactions |
ISO |
KHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate] |
CTD |
PMID:19158351 |
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NCBI chr 6:26,810,577...26,821,013
Ensembl chr 6:26,810,579...26,820,959
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G |
Kif5a |
kinesin family member 5A |
multiple interactions increases hydrolysis |
ISO |
Adenosine Triphosphate inhibits the reaction [zinc chloride results in decreased activity of KIF5A protein]; Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]; Egtazic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]] |
CTD |
PMID:24239783 PMID:28122263 |
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NCBI chr 7:70,515,832...70,552,897
Ensembl chr 7:70,513,343...70,556,827
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G |
Lep |
leptin |
multiple interactions |
EXP |
[[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein; [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein |
CTD |
PMID:10780946 |
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NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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G |
Lipe |
lipase E, hormone sensitive type |
increases activity |
ISO |
Adenosine Triphosphate results in increased activity of LIPE protein |
CTD |
PMID:7155675 |
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NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
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G |
LOC102552569 |
P2Y purinoceptor 11-like |
multiple interactions affects binding |
ISO |
[Adenosine Triphosphate binds to P2RY11 protein] which results in decreased expression of BCL2 protein; [Adenosine Triphosphate binds to P2RY11 protein] which results in increased susceptibility to Cisplatin |
CTD |
PMID:21503959 |
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NCBI chr 8:21,910,636...21,911,499
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G |
Lpl |
lipoprotein lipase |
affects response to substance |
ISO |
LPL protein affects the susceptibility to Adenosine Triphosphate |
CTD |
PMID:11786490 |
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NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
affects binding |
ISO |
Adenosine Triphosphate binds to MAP2K1 protein |
CTD |
PMID:17693661 |
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NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation increases activity |
ISO EXP |
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]; [Alcohols co-treated with Adenosine Triphosphate] results in increased activity of MAPK1 protein; Alcohols inhibits the reaction [Adenosine Triphosphate results in increased activity of MAPK1 protein]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein] azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:12513686 PMID:15034929 PMID:21503959 PMID:24300283 PMID:26104857 PMID:26522449 PMID:30502331 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation increases activity |
ISO EXP |
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]; [Alcohols co-treated with Adenosine Triphosphate] results in increased activity of MAPK3 protein; Alcohols inhibits the reaction [Adenosine Triphosphate results in increased activity of MAPK3 protein]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein] azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:12513686 PMID:15034929 PMID:21503959 PMID:24300283 PMID:26104857 PMID:26522449 PMID:30502331 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions |
EXP |
[annonacin results in decreased abundance of Adenosine Triphosphate] which affects the localization of MAPT protein |
CTD |
PMID:17634376 |
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NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
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G |
Metrnl |
meteorin-like, glial cell differentiation regulator |
multiple interactions |
ISO |
METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Adenosine Triphosphate] |
CTD |
PMID:30213948 |
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NCBI chr10:110,893,261...110,907,256
Ensembl chr10:110,893,232...110,907,243
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G |
Mfn2 |
mitofusin 2 |
decreases response to substance multiple interactions increases chemical synthesis |
ISO EXP |
MFN2 results in decreased susceptibility to Adenosine Triphosphate deficiency MFN2 protein inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased chemical synthesis of Adenosine Triphosphate] MFN2 protein inhibits the reaction [TNF protein results in decreased chemical synthesis of Adenosine Triphosphate] MFN2 protein results in increased chemical synthesis of Adenosine Triphosphate |
CTD |
PMID:22292091 PMID:24898700 PMID:25416777 |
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NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions increases activity increases secretion |
EXP ISO |
1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]; SB 3CT compound inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]; wortmannin inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein] azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of MMP9 protein] Adenosine Triphosphate results in increased secretion of MMP9 protein |
CTD |
PMID:20195827 PMID:26522449 |
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NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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G |
Mt-atp6 |
mitochondrially encoded ATP synthase membrane subunit 6 |
affects abundance |
EXP |
ATP6 protein affects the abundance of Adenosine Triphosphate |
CTD |
PMID:18273840 |
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NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
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G |
Mt-co3 |
mitochondrially encoded cytochrome c oxidase III |
increases abundance |
ISO |
COX3 protein results in increased abundance of Adenosine Triphosphate |
CTD |
PMID:17428446 |
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NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
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G |
Mvd |
mevalonate diphosphate decarboxylase |
increases hydrolysis |
ISO |
MVD protein results in increased hydrolysis of Adenosine Triphosphate |
CTD |
PMID:9392419 |
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NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
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G |
Mvk |
mevalonate kinase |
increases hydrolysis multiple interactions |
ISO |
MVK protein results in increased hydrolysis of Adenosine Triphosphate 3,3-dimethylallyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; dolichol monophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; Farnesol inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranyl diphosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; isopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate] |
CTD |
PMID:9392419 |
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NCBI chr12:47,904,266...47,920,457
Ensembl chr12:47,904,719...47,919,400
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G |
Myh7 |
myosin heavy chain 7 |
increases abundance |
ISO |
MYH7 gene mutant form results in increased abundance of Adenosine Triphosphate |
CTD |
PMID:29741611 |
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NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
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G |
Nadsyn1 |
NAD synthetase 1 |
multiple interactions |
ISO |
[Ammonium Chloride co-treated with nicotinic acid adenine dinucleotide co-treated with Adenosine Triphosphate] results in increased activity of NADSYN1 protein; [NADSYN1 protein co-treated with Ammonium Chloride co-treated with nicotinic acid adenine dinucleotide co-treated with Adenosine Triphosphate] results in increased chemical synthesis of NAD |
CTD |
PMID:12547821 |
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NCBI chr 1:216,985,710...217,013,743
Ensembl chr 1:216,985,714...217,013,702
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G |
Ncs1 |
neuronal calcium sensor 1 |
multiple interactions increases response to substance |
EXP |
NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]] NCS1 protein results in increased susceptibility to Adenosine Triphosphate |
CTD |
PMID:12471042 |
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NCBI chr 3:10,556,250...10,602,672
Ensembl chr 3:10,553,589...10,602,672
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G |
Nfatc1 |
nuclear factor of activated T-cells 1 |
affects localization multiple interactions |
EXP ISO |
Adenosine Triphosphate affects the localization of NFATC1 protein azetidine analog inhibits the reaction [Adenosine Triphosphate affects the localization of NFATC1 protein] |
CTD |
PMID:21464294 PMID:26522449 |
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NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
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G |
Nfatc3 |
nuclear factor of activated T-cells 3 |
affects localization |
EXP |
Adenosine Triphosphate affects the localization of NFATC3 protein |
CTD |
PMID:21464294 |
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NCBI chr19:38,039,542...38,114,003
Ensembl chr19:38,039,564...38,114,003
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
EXP ISO |
Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]] [Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of NFKBIA protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of NFKBIA protein] |
CTD |
PMID:21464294 PMID:24149798 |
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NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Ngf |
nerve growth factor |
multiple interactions |
EXP |
[NGF protein co-treated with Adenosine Triphosphate] results in increased uptake of Calcium |
CTD |
PMID:1374475 |
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NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
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G |
Nlrp1a |
NLR family, pyrin domain containing 1A |
multiple interactions |
ISO |
[Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP1 mRNA |
CTD |
PMID:24149798 |
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NCBI chr10:57,692,474...57,747,608
Ensembl chr10:57,692,474...57,822,498
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PML protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]] [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP3 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein; KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein] |
CTD |
PMID:18604214 PMID:23430110 PMID:24149798 PMID:26086368 PMID:26586371 |
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NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
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G |
Nolc1 |
nucleolar and coiled-body phosphoprotein 1 |
multiple interactions |
ISO |
Adenosine Triphosphate affects the reaction [Doxorubicin binds to NOLC1 protein] |
CTD |
PMID:17129415 |
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NCBI chr 1:265,829,055...265,839,819
Ensembl chr 1:265,829,108...265,839,818
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions increases expression |
ISO EXP |
NOS2 protein affects the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein] azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of NOS2 protein] [Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]]; Cyclosporine inhibits the reaction [[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Adenosine Triphosphate results in increased expression of NOS2 protein]; NOS2 protein affects the reaction [Adenosine Triphosphate results in increased abundance of Nitric Oxide] |
CTD |
PMID:21464294 PMID:26522449 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
Adenosine Triphosphate affects the reaction [Alcohols affects the phosphorylation of NOS3 protein]; Adenosine Triphosphate inhibits the reaction [Alcohols results in decreased expression of NOS3 protein] |
CTD |
PMID:24300283 |
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NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
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G |
Npy |
neuropeptide Y |
affects response to substance |
ISO |
NPY protein affects the susceptibility to Adenosine Triphosphate |
CTD |
PMID:15003356 |
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NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
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G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
increases expression |
EXP |
Adenosine Triphosphate results in increased expression of NR4A1 mRNA |
CTD |
PMID:10723097 |
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NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
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G |
Oas1a |
2'-5' oligoadenylate synthetase 1A |
multiple interactions |
ISO |
[OAS1 protein results in increased metabolism of Adenosine Triphosphate] which results in increased chemical synthesis of 2',5'-oligoadenylate |
CTD |
PMID:15732009 |
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NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
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G |
Oxt |
oxytocin/neurophysin I prepropeptide |
multiple interactions increases secretion |
EXP |
Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein] |
CTD |
PMID:11102496 |
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NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
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G |
P2rx1 |
purinergic receptor P2X 1 |
multiple interactions |
EXP |
geldanamycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1]; herbimycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1]; monorden promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1] |
CTD |
PMID:11930156 |
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NCBI chr10:59,566,268...59,581,328
Ensembl chr10:59,566,223...59,581,325
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G |
P2rx2 |
purinergic receptor P2X 2 |
multiple interactions increases activity affects response to substance |
EXP ISO |
1-amino-4-(3-(4,6-dichloro(1,3,5)triazine-2-ylamino)phenylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; Acetylcysteine inhibits the reaction [Rotenone promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; Cadmium Chloride affects the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; cobaltous chloride affects the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Copper promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; cupric chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Mercuric Chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; methyl methanethiosulfonate inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; methyl methanethiosulfonate inhibits the reaction [Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; myxothiazol promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; nickel chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; palladium chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Rotenone promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; zinc chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein] P2RX2 protein affects the susceptibility to Adenosine Triphosphate |
CTD |
PMID:15081800 PMID:16190872 PMID:19793987 PMID:21207957 |
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NCBI chr12:52,397,666...52,401,005
Ensembl chr12:52,397,792...52,401,015
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G |
P2rx3 |
purinergic receptor P2X 3 |
multiple interactions affects activity |
EXP |
Eugenol inhibits the reaction [P2RX3 protein affects the activity of Adenosine Triphosphate] |
CTD |
PMID:19967073 |
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NCBI chr 3:72,403,992...72,447,801
Ensembl chr 3:72,403,993...72,447,801
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G |
P2rx4 |
purinergic receptor P2X 4 |
multiple interactions increases activity |
EXP ISO |
[Cadmium co-treated with Zinc] promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; [Mercury co-treated with Copper] inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Cadmium promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Cobalt promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Copper inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Copper inhibits the reaction [Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]]; Mercury inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein] 5-(3-bromophenyl)-1,3-dihydro-2H-benzofuro(3,2-e)-1,4-diazepin-2-one inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; [ginsenoside M1 co-treated with Adenosine Triphosphate] results in increased activity of P2RX4 protein; [Resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 mRNA; [Resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 protein; ginsenoside M1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; ginsenoside Rb1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; ginsenoside Rd promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Ivermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein] |
CTD |
PMID:10737610 PMID:15629187 PMID:19793987 PMID:21638035 PMID:24149798 PMID:30545933 |
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NCBI chr12:39,308,022...39,325,673
Ensembl chr12:39,308,025...39,325,673
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G |
P2rx7 |
purinergic receptor P2X 7 |
multiple interactions increases expression decreases response to substance increases response to substance increases activity |
ISO EXP |
[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 protein; AZ10606120 inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]; P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased secretion of SELL protein]; P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased transport of Barium]; Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 mRNA]; Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 protein] Adenosine Triphosphate results in increased expression of P2RX7 protein P2RX7 gene mutant form results in decreased susceptibility to Adenosine Triphosphate P2RX7 protein results in increased susceptibility to Adenosine Triphosphate 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of P2RX7 protein]; coomassie Brilliant Blue inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein] |
CTD |
PMID:11003599 PMID:17728465 PMID:19023039 PMID:21638035 PMID:23565201 PMID:24101734 PMID:24149798 PMID:26522449 PMID:27466191 PMID:30545933 PMID:31504961 |
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NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
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G |
P2ry1 |
purinergic receptor P2Y1 |
multiple interactions affects activity |
ISO EXP |
[Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein] which results in increased abundance of Calcium; Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [P2RY1 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]; P2RY1 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]; Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein] which results in increased abundance of Calcium] [N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate binds to and results in decreased activity of P2RY1 protein] inhibits the reaction [Adenosine Triphosphate results in increased uptake of Calcium] Adenosine Triphosphate affects the activity of P2RY1 protein |
CTD |
PMID:12694404 PMID:15243297 PMID:16973929 PMID:22129738 |
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NCBI chr 2:151,314,818...151,320,312
Ensembl chr 2:151,314,818...151,320,319
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G |
P2ry13 |
purinergic receptor P2Y13 |
multiple interactions |
ISO |
MRS 2211 inhibits the reaction [P2RY13 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]; P2RY13 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide] |
CTD |
PMID:22129738 |
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NCBI chr 2:149,429,648...149,432,864
Ensembl chr 2:149,430,854...149,432,106
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G |
P2ry2 |
purinergic receptor P2Y2 |
multiple interactions affects activity increases activity |
ISO EXP |
[Adenosine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Calcium [Adenosine Triphosphate results in increased activity of P2RY2 protein] which results in increased uptake of Calcium Adenosine Triphosphate affects the activity of P2RY2 protein |
CTD |
PMID:11527950 PMID:15243297 PMID:17003265 |
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NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424
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G |
P2ry4 |
pyrimidinergic receptor P2Y4 |
multiple interactions |
ISO |
[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium; Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein; Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium] |
CTD |
PMID:12694404 |
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NCBI chr X:70,421,599...70,447,109
Ensembl chr X:70,426,951...70,428,364
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G |
P2ry6 |
pyrimidinergic receptor P2Y6 |
multiple interactions |
ISO |
N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea inhibits the reaction [P2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]; P2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide] |
CTD |
PMID:22129738 |
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NCBI chr 1:165,972,439...166,008,348
Ensembl chr 1:165,972,440...165,997,751
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G |
Panx1 |
Pannexin 1 |
decreases activity multiple interactions increases export |
ISO |
Adenosine Triphosphate results in decreased activity of PANX1 protein Carbenoxolone inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]; Probenecid inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate] |
CTD |
PMID:19023039 PMID:19213873 |
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NCBI chr 8:13,567,185...13,606,040
Ensembl chr 8:13,566,739...13,606,040
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases expression |
ISO |
PARP1 mutant form inhibits the reaction [Cadmium results in decreased abundance of Adenosine Triphosphate] PARP1 protein affects the reaction [pyrithione zinc results in decreased abundance of Adenosine Triphosphate]; PARP1 protein affects the reaction [Zinc results in decreased abundance of Adenosine Triphosphate] Adenosine Triphosphate results in increased expression of PARP1 protein |
CTD |
PMID:17728843 PMID:19809895 PMID:21767558 PMID:22253048 |
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NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
multiple interactions affects response to substance |
ISO |
[PDK1 protein affects the susceptibility to Adenosine Triphosphate] which affects the abundance of Calcium; Adenosine Triphosphate promotes the reaction [PDK1 protein affects the abundance of Calcium]; tubacin affects the reaction [[PDK1 protein affects the susceptibility to Adenosine Triphosphate] which affects the abundance of Calcium] |
CTD |
PMID:28887310 |
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NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
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G |
Pfkm |
phosphofructokinase, muscle |
multiple interactions |
ISO |
Adenosine Triphosphate promotes the reaction [resveratrol results in decreased activity of PFKM protein] |
CTD |
PMID:23454376 |
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NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132
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G |
Pgp |
phosphoglycolate phosphatase |
decreases phosphorylation |
ISO |
PGP protein results in decreased phosphorylation of Adenosine Triphosphate |
CTD |
PMID:24338473 |
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NCBI chr10:13,836,105...13,838,731
Ensembl chr10:13,836,128...13,838,765
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G |
Pik3ca |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
multiple interactions affects binding |
ISO |
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [Adenosine Triphosphate binds to PIK3CA protein]; Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]] |
CTD |
PMID:17550345 PMID:18754654 |
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NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
multiple interactions |
ISO |
Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]] |
CTD |
PMID:17550345 |
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NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
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G |
Pla2g4a |
phospholipase A2 group IVA |
increases activity |
ISO |
Adenosine Triphosphate results in increased activity of PLA2G4A protein |
CTD |
PMID:10535451 |
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NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
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G |
Plau |
plasminogen activator, urokinase |
increases secretion |
ISO |
Adenosine Triphosphate results in increased secretion of PLAU protein |
CTD |
PMID:20177776 |
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NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
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G |
Plpp3 |
phospholipid phosphatase 3 |
decreases chemical synthesis |
ISO |
PLPP3 gene mutant form results in decreased chemical synthesis of Adenosine Triphosphate |
CTD |
PMID:28982073 |
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NCBI chr 5:124,690,214...124,765,499
Ensembl chr 5:124,690,214...124,765,498
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G |
Pml |
PML nuclear body scaffold |
multiple interactions |
ISO |
[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PML protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [PML protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of PML protein; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased abundance of Reactive Oxygen Species]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; PML protein promotes the reaction [[resiquimod co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein] |
CTD |
PMID:23430110 |
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NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
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G |
Pmvk |
phosphomevalonate kinase |
increases hydrolysis |
ISO |
PMVK protein results in increased hydrolysis of Adenosine Triphosphate |
CTD |
PMID:9392419 |
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NCBI chr 2:188,784,329...188,793,890
Ensembl chr 2:188,784,222...188,793,895
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
[Fenofibrate results in increased activity of PPARA protein] which results in decreased abundance of Adenosine Triphosphate |
CTD |
PMID:19593819 |
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NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions decreases abundance |
ISO |
FASN protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]; rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]; UCP1 protein promotes the reaction [PPARG protein mutant form results in decreased abundance of Adenosine Triphosphate]; UCP1 protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]] PPARG protein mutant form results in decreased abundance of Adenosine Triphosphate; PPARG protein results in decreased abundance of Adenosine Triphosphate |
CTD |
PMID:26670611 |
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NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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G |
Ppp5c |
protein phosphatase 5, catalytic subunit |
multiple interactions |
ISO |
Adenosine Triphosphate binds to and affects the folding of PPP5C protein; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to PPP5C protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to PPP5C protein] |
CTD |
PMID:23184943 |
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NCBI chr 1:78,944,054...78,968,361
Ensembl chr 1:78,944,040...78,968,329
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G |
Prdx2 |
peroxiredoxin 2 |
increases expression |
EXP |
Adenosine Triphosphate results in increased expression of PRDX2 protein modified form |
CTD |
PMID:16178011 |
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NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
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G |
Prkca |
protein kinase C, alpha |
multiple interactions |
ISO |
[[Adenosine Triphosphate co-treated with PRKCA protein] results in increased phosphorylation of RALBP1 protein] which results in increased transport of Doxorubicin |
CTD |
PMID:16087181 |
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NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein] |
CTD |
PMID:24149798 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Pycard |
PYD and CARD domain containing |
multiple interactions |
ISO |
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in decreased expression of PYCARD mRNA; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in decreased expression of PYCARD mRNA] [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]; PYCARD gene mutant form inhibits the reaction [Adenosine Triphosphate results in increased abundance of G(M3) Ganglioside]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein] |
CTD |
PMID:18604214 PMID:23430110 PMID:24149798 PMID:24475307 |
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NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
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G |
Ralbp1 |
ralA binding protein 1 |
multiple interactions |
ISO |
[[Adenosine Triphosphate co-treated with PRKCA protein] results in increased phosphorylation of RALBP1 protein] which results in increased transport of Doxorubicin; Adenosine Triphosphate promotes the reaction [RALBP1 protein affects the transport of Leukotriene C4] |
CTD |
PMID:15386349 PMID:16087181 |
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NCBI chr 9:113,579,107...113,598,477
Ensembl chr 9:113,579,107...113,598,480
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP ISO |
[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]]; Cyclosporine inhibits the reaction [[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]] [Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of RELA protein; NOS2 protein affects the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein]; Resveratrol promotes the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of RELA protein]; S-Nitrosoglutathione promotes the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein] |
CTD |
PMID:21464294 PMID:24149798 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Rhof |
ras homolog family member F, filopodia associated |
multiple interactions increases expression |
ISO |
Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of RHOF mRNA] |
CTD |
PMID:29733962 |
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NCBI chr12:38,879,763...38,894,095
Ensembl chr12:38,880,377...38,894,582
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G |
S100a10 |
S100 calcium binding protein A10 |
increases expression |
ISO |
Adenosine Triphosphate results in increased expression of S100A10 mRNA |
CTD |
PMID:29733962 |
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NCBI chr 2:193,892,589...193,901,236
Ensembl chr 2:193,892,589...193,901,236
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G |
S100a11 |
S100 calcium binding protein A11 |
increases expression |
ISO |
Adenosine Triphosphate results in increased expression of S100A11 mRNA |
CTD |
PMID:29733962 |
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NCBI chr 2:193,863,185...193,868,646
Ensembl chr 2:193,866,951...193,868,502
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G |
S100a4 |
S100 calcium-binding protein A4 |
multiple interactions increases expression |
ISO |
Adenosine Triphosphate results in increased expression of and results in increased secretion of S100A4 protein; Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of S100A4 protein] Adenosine Triphosphate results in increased expression of S100A4 mRNA |
CTD |
PMID:29733962 |
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NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
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G |
S100a6 |
S100 calcium binding protein A6 |
increases expression |
ISO |
Adenosine Triphosphate results in increased expression of S100A6 mRNA |
CTD |
PMID:29733962 |
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NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
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G |
Sell |
selectin L |
multiple interactions |
ISO |
P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased secretion of SELL protein] |
CTD |
PMID:11003599 |
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NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
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G |
Sftpa1 |
surfactant protein A1 |
multiple interactions |
ISO |
[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]; Ozone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; Ozone inhibits the reaction [SFTPA1 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]] |
CTD |
PMID:15065867 |
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NCBI chr16:18,716,019...18,719,404
Ensembl chr16:18,716,019...18,719,403
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G |
Sftpb |
surfactant protein B |
increases secretion multiple interactions |
ISO EXP |
Adenosine Triphosphate results in increased secretion of SFTPB protein Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPB protein] |
CTD |
PMID:11704537 PMID:14565945 |
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NCBI chr 4:100,166,855...100,175,941
Ensembl chr 4:100,166,863...100,175,938
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G |
Sftpc |
surfactant protein C |
increases secretion multiple interactions |
EXP ISO |
Adenosine Triphosphate results in increased secretion of SFTPC protein Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPC protein] |
CTD |
PMID:11704537 PMID:14565945 |
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NCBI chr15:52,211,538...52,214,480
Ensembl chr15:52,211,544...52,214,616
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G |
Sirt1 |
sirtuin 1 |
multiple interactions |
EXP |
[SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate]; SIRT1 protein promotes the reaction [[Glucose results in increased abundance of Adenosine Triphosphate] which results in increased expression of INS1 protein]; SIRT1 protein promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate] |
CTD |
PMID:16366736 |
|
NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
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G |
Sirt3 |
sirtuin 3 |
multiple interactions |
ISO |
SIRT3 protein inhibits the reaction [Metformin results in decreased abundance of Adenosine Triphosphate] |
CTD |
PMID:23166782 |
|
NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
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G |
Slc25a14 |
solute carrier family 25 member 14 |
decreases chemical synthesis |
ISO |
SLC25A14 protein results in decreased chemical synthesis of Adenosine Triphosphate |
CTD |
PMID:20600837 |
|
NCBI chr X:135,470,855...135,509,223
Ensembl chr X:135,470,915...135,509,221
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G |
Slc2a1 |
solute carrier family 2 member 1 |
decreases stability |
ISO |
Adenosine Triphosphate results in decreased stability of SLC2A1 protein |
CTD |
PMID:11420438 |
|
NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
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G |
Slc46a1 |
solute carrier family 46 member 1 |
multiple interactions |
ISO |
[SLC46A1 protein results in increased susceptibility to N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid] which results in decreased chemical synthesis of Adenosine Triphosphate |
CTD |
PMID:21879757 |
|
NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828
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G |
Slc5a5 |
solute carrier family 5 member 5 |
multiple interactions |
ISO |
Adenosine Triphosphate inhibits the reaction [TSHB protein results in increased expression of SLC5A5 protein] |
CTD |
PMID:16439463 |
|
NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
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G |
Snca |
synuclein alpha |
multiple interactions decreases abundance |
ISO |
GW8510 inhibits the reaction [SNCA protein results in decreased abundance of Adenosine Triphosphate]; SB 216763 inhibits the reaction [SNCA protein results in decreased abundance of Adenosine Triphosphate] |
CTD |
PMID:24989254 |
|
NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
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G |
Sod1 |
superoxide dismutase 1 |
increases expression |
EXP ISO |
Adenosine Triphosphate results in increased expression of SOD1 protein |
CTD |
PMID:16178011 PMID:22129738 |
|
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Sod2 |
superoxide dismutase 2 |
affects chemical synthesis decreases abundance multiple interactions |
ISO |
SOD2 protein affects the chemical synthesis of Adenosine Triphosphate SOD2 gene mutant form results in decreased abundance of Adenosine Triphosphate MK-886 promotes the reaction [SOD2 gene mutant form results in decreased abundance of Adenosine Triphosphate] |
CTD |
PMID:20638473 PMID:25362851 |
|
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Stxbp2 |
syntaxin binding protein 2 |
multiple interactions |
ISO |
STXBP2 protein affects the reaction [F2 protein results in increased transport of Adenosine Triphosphate] |
CTD |
PMID:30696774 |
|
NCBI chr12:2,180,101...2,191,863
Ensembl chr12:2,180,150...2,191,175
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G |
Sugt1 |
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone |
multiple interactions |
ISO |
Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to SUGT1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]] |
CTD |
PMID:23184943 |
|
NCBI chr15:61,873,158...61,913,983
Ensembl chr15:61,873,056...61,914,072
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G |
Syn2 |
synapsin II |
multiple interactions |
ISO |
SYN2 mutant form inhibits the reaction [Adenosine Triphosphate results in increased abundance of Calcium] |
CTD |
PMID:18701217 |
|
NCBI chr 4:147,037,179...147,195,096
Ensembl chr 4:147,037,179...147,195,096
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G |
Tac1 |
tachykinin, precursor 1 |
increases secretion multiple interactions |
EXP |
Adenosine Triphosphate results in increased secretion of TAC1 protein Iloprost promotes the reaction [Adenosine Triphosphate results in increased secretion of TAC1 protein] |
CTD |
PMID:16039053 |
|
NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
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G |
Taldo1 |
transaldolase 1 |
increases abundance |
ISO |
TALDO1 gene mutant form results in increased abundance of Adenosine Triphosphate |
CTD |
PMID:19436114 |
|
NCBI chr 1:214,375,555...214,385,886
Ensembl chr 1:214,375,515...214,385,885
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G |
Tas2r145 |
taste receptor, type 2, member 145 |
increases activity |
ISO |
Adenosine Triphosphate results in increased activity of TAS2R131 protein |
CTD |
PMID:29347925 |
|
NCBI chr 4:167,017,816...167,018,766
Ensembl chr 4:167,017,816...167,018,748
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G |
Timm17a |
translocase of inner mitochondrial membrane 17A |
multiple interactions decreases expression |
ISO |
1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in decreased expression of TIMM17A protein] |
CTD |
PMID:24315374 |
|
NCBI chr13:52,124,641...52,136,127
Ensembl chr13:52,124,635...52,136,127
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
decreases secretion multiple interactions |
ISO |
Adenosine Triphosphate results in decreased secretion of TIMP1 protein azetidine analog inhibits the reaction [Adenosine Triphosphate results in decreased secretion of TIMP1 protein] |
CTD |
PMID:26522449 |
|
NCBI chr X:1,364,771...1,369,451
Ensembl chr X:1,364,786...1,369,384
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases chemical synthesis |
ISO EXP |
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of TNF protein; Adenosine Triphosphate deficiency inhibits the reaction [TNF protein results in increased transport of Chlorides]; Adenosine Triphosphate deficiency inhibits the reaction [TNF protein results in increased transport of Potassium]; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased secretion of TNF protein] TNF protein promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased chemical synthesis of Adenosine Triphosphate] TNF protein results in decreased chemical synthesis of Adenosine Triphosphate [Asbestos, Amosite co-treated with TNF protein] results in increased metabolism of Adenosine Triphosphate; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; MFN2 protein inhibits the reaction [TNF protein results in decreased chemical synthesis of Adenosine Triphosphate]; Rosiglitazone inhibits the reaction [TNF protein results in decreased chemical synthesis of Adenosine Triphosphate]; Vitamin K 3 promotes the reaction [[Asbestos, Amosite co-treated with TNF protein] results in increased metabolism of Adenosine Triphosphate] |
CTD |
PMID:8817062 PMID:10783394 PMID:14623498 PMID:17707769 PMID:23430110 PMID:24898700 PMID:26522449 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tnfsf11 |
TNF superfamily member 11 |
increases abundance |
ISO |
TNFSF11 protein results in increased abundance of Adenosine Triphosphate |
CTD |
PMID:26287518 |
|
NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
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G |
Top2a |
DNA topoisomerase II alpha |
multiple interactions increases hydrolysis |
ISO |
Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]; copper-thiosemicarbazone complex analog inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]; Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]]; Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate]; Etoposide metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]; Thiosemicarbazones analog inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate] TOP2A protein results in increased hydrolysis of Adenosine Triphosphate; TOP2A results in increased hydrolysis of Adenosine Triphosphate |
CTD |
PMID:20855424 PMID:26982206 PMID:27533850 PMID:29272108 |
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NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
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G |
Top2b |
DNA topoisomerase II beta |
increases hydrolysis multiple interactions |
ISO |
TOP2B protein results in increased hydrolysis of Adenosine Triphosphate cannabidiol hydroxyquinone inhibits the reaction [TOP2B protein results in increased hydrolysis of Adenosine Triphosphate]; Cannabidiol metabolite inhibits the reaction [TOP2B protein results in increased hydrolysis of Adenosine Triphosphate] |
CTD |
PMID:29272108 |
|
NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
TP53 protein inhibits the reaction [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] |
CTD |
PMID:21042727 |
|
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Trpm4 |
transient receptor potential cation channel, subfamily M, member 4 |
decreases activity |
ISO EXP |
Adenosine Triphosphate results in decreased activity of TRPM4 protein |
CTD |
PMID:16966582 PMID:17188667 |
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NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
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G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
multiple interactions |
EXP |
[Capsaicin binds to and affects the activity of TRPV1 protein] which results in increased secretion of Adenosine Triphosphate |
CTD |
PMID:19860742 |
|
NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
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G |
Tshb |
thyroid stimulating hormone subunit beta |
multiple interactions |
ISO |
Adenosine Triphosphate inhibits the reaction [TSHB protein results in increased expression of SLC5A5 protein] |
CTD |
PMID:16439463 |
|
NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
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G |
Txn1 |
thioredoxin 1 |
increases expression |
ISO |
Adenosine Triphosphate results in increased expression of TXN protein |
CTD |
PMID:22129738 |
|
NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
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G |
Txnip |
thioredoxin interacting protein |
increases activity |
EXP |
Adenosine Triphosphate results in increased activity of TXNIP mRNA |
CTD |
PMID:21832250 |
|
NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
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G |
Ucp1 |
uncoupling protein 1 |
multiple interactions decreases abundance |
EXP ISO |
Adenosine Triphosphate inhibits the reaction [UCP1 protein results in increased transport of Protons] UCP1 results in decreased abundance of Adenosine Triphosphate UCP1 protein promotes the reaction [PPARG protein mutant form results in decreased abundance of Adenosine Triphosphate]; UCP1 protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]] |
CTD |
PMID:12734183 PMID:26670611 |
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NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
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G |
Ucp2 |
uncoupling protein 2 |
multiple interactions |
ISO EXP |
Adenosine Triphosphate inhibits the reaction [UCP2 protein results in increased transport of Protons] [SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate] |
CTD |
PMID:12734183 PMID:16366736 |
|
NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
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G |
Ucp3 |
uncoupling protein 3 |
multiple interactions |
ISO |
Adenosine Triphosphate inhibits the reaction [UCP3 protein results in increased transport of Protons] |
CTD |
PMID:12734183 |
|
NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
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G |
Vdac1 |
voltage-dependent anion channel 1 |
multiple interactions |
ISO |
VDAC1 mutant form inhibits the reaction [chromium hexavalent ion results in decreased abundance of Adenosine Triphosphate] |
CTD |
PMID:22858589 |
|
NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
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G |
Xrcc1 |
X-ray repair cross complementing 1 |
multiple interactions increases abundance decreases abundance |
ISO |
Acetylcysteine inhibits the reaction [XRCC1 gene mutant form results in decreased abundance of Adenosine Triphosphate]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased abundance of Adenosine Triphosphate] |
CTD |
PMID:30998386 |
|
NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases hydrolysis |
ISO |
ABCB1 protein results in increased hydrolysis of Guanosine Triphosphate |
CTD |
PMID:2900677 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
Guanosine Triphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein] |
CTD |
PMID:1848756 |
|
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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G |
App |
amyloid beta precursor protein |
increases secretion |
ISO |
Guanosine Triphosphate results in increased secretion of APP protein modified form |
CTD |
PMID:22906069 |
|
NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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G |
Cdc42 |
cell division cycle 42 |
multiple interactions |
ISO EXP |
Resveratrol promotes the reaction [CDC42 protein binds to Guanosine Triphosphate]; Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein]; Zoledronic Acid results in increased expression of [CDC42 protein binds to Guanosine Triphosphate] Ethanol results in decreased expression of [CDC42 protein binds to Guanosine Triphosphate] Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein]; Zoledronic Acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein] |
CTD |
PMID:15217905 PMID:16734383 PMID:20829428 PMID:28871336 |
|
NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
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G |
Crh |
corticotropin releasing hormone |
decreases activity |
EXP |
Guanosine Triphosphate results in decreased activity of CRH protein |
CTD |
PMID:2153673 |
|
NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
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G |
Csf1 |
colony stimulating factor 1 |
multiple interactions |
ISO |
CSF1 protein results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]; Risedronic Acid promotes the reaction [CSF1 protein results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]] |
CTD |
PMID:16734383 |
|
NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
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G |
Fut8 |
fucosyltransferase 8 |
decreases activity |
ISO |
Guanosine Triphosphate results in decreased activity of FUT8 protein |
CTD |
PMID:12770769 |
|
NCBI chr 6:100,305,957...100,537,208
Ensembl chr 6:100,337,226...100,537,224
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G |
Gucy1a1 |
guanylate cyclase 1 soluble subunit alpha 1 |
multiple interactions |
ISO |
[dicyanocobinamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]] which results in increased metabolism of Guanosine Triphosphate |
CTD |
PMID:22171090 |
|
NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
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G |
Gucy1b1 |
guanylate cyclase 1 soluble subunit beta 1 |
multiple interactions |
ISO |
[dicyanocobinamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]] which results in increased metabolism of Guanosine Triphosphate |
CTD |
PMID:22171090 |
|
NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
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G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
[Enzyme Inhibitors binds to and results in decreased activity of SOS1 protein] inhibits the reaction [HRAS protein binds to Guanosine Triphosphate] |
CTD |
PMID:25825487 |
|
NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
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G |
Hrh1 |
histamine receptor H 1 |
multiple interactions |
ISO |
Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]] |
CTD |
PMID:2419744 |
|
NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
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G |
Hrh3 |
histamine receptor H3 |
multiple interactions affects binding |
ISO EXP |
6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]]; alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein] |
CTD |
PMID:21634396 |
|
NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions |
EXP |
Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]; Guanosine Triphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]] |
CTD |
PMID:21126535 |
|
NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
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G |
Kras |
KRAS proto-oncogene, GTPase |
affects binding multiple interactions increases hydrolysis |
ISO |
Guanosine Triphosphate binds to KRAS protein; Guanosine Triphosphate binds to KRAS protein mutant form KRAS protein mutant form inhibits the reaction [RASA1 protein promotes the reaction [KRAS protein results in increased hydrolysis of Guanosine Triphosphate]]; RASA1 protein promotes the reaction [KRAS protein results in increased hydrolysis of Guanosine Triphosphate] KRAS protein mutant form results in increased hydrolysis of Guanosine Triphosphate; KRAS protein results in increased hydrolysis of Guanosine Triphosphate |
CTD |
PMID:28154176 |
|
NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
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G |
Mtnr1b |
melatonin receptor 1B |
multiple interactions |
ISO |
Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]; Guanosine Triphosphate inhibits the reaction [Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]] |
CTD |
PMID:28027439 |
|
NCBI chr 8:14,359,270...14,373,894
Ensembl chr 8:14,359,270...14,373,894
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G |
Oprm1 |
opioid receptor, mu 1 |
affects binding multiple interactions |
EXP |
Guanosine Triphosphate binds to OPRM1 protein Dronabinol promotes the reaction [Guanosine Triphosphate binds to OPRM1 protein] |
CTD |
PMID:16823391 |
|
NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
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G |
P2ry4 |
pyrimidinergic receptor P2Y4 |
multiple interactions |
EXP |
Guanosine Triphosphate binds to and results in increased activity of P2RY4 protein |
CTD |
PMID:15654852 |
|
NCBI chr X:70,421,599...70,447,109
Ensembl chr X:70,426,951...70,428,364
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G |
Panx1 |
Pannexin 1 |
decreases activity |
ISO |
Guanosine Triphosphate results in decreased activity of PANX1 protein |
CTD |
PMID:19023039 |
|
NCBI chr 8:13,567,185...13,606,040
Ensembl chr 8:13,566,739...13,606,040
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G |
Pgp |
phosphoglycolate phosphatase |
decreases phosphorylation |
ISO |
PGP protein results in decreased phosphorylation of Guanosine Triphosphate |
CTD |
PMID:24338473 |
|
NCBI chr10:13,836,105...13,838,731
Ensembl chr10:13,836,128...13,838,765
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G |
Pomc |
proopiomelanocortin |
multiple interactions |
ISO |
[Guanosine Triphosphate co-treated with Lithium] results in decreased activity of POMC protein modified form; [Guanosine Triphosphate co-treated with Potassium] results in decreased activity of POMC protein modified form; [Guanosine Triphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form |
CTD |
PMID:2550106 |
|
NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
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G |
Rab3a |
RAB3A, member RAS oncogene family |
affects binding increases cleavage multiple interactions |
EXP |
[RAB3A protein binds to Guanosine Triphosphate] which binds to RABGAP1 protein; Guanosine Triphosphate binds to RAB3A protein; RAB3A protein binds to Guanosine Triphosphate; SNCA protein binds to [RAB3A protein binds to Guanosine Triphosphate] RAB3A protein results in increased cleavage of Guanosine Triphosphate [alpha-latrotoxin promotes the reaction [RAB3A protein results in increased cleavage of Guanosine Triphosphate]] promotes the reaction [Guanosine Diphosphate binds to RAB3A protein]; [black widow spider venom promotes the reaction [RAB3A protein results in increased cleavage of Guanosine Triphosphate]] promotes the reaction [Guanosine Diphosphate binds to RAB3A protein]; manganese chloride inhibits the reaction [[RAB3A protein binds to Guanosine Triphosphate] which binds to RABGAP1 protein]; manganese chloride promotes the reaction [SNCA protein binds to [RAB3A protein binds to Guanosine Triphosphate]]; manganese chloride results in increased expression of [RAB3A protein binds to Guanosine Triphosphate]; SNCA protein promotes the reaction [manganese chloride inhibits the reaction [[RAB3A protein binds to Guanosine Triphosphate] which binds to RABGAP1 protein]] |
CTD |
PMID:7929154 PMID:29289693 |
|
NCBI chr16:20,435,098...20,439,206
Ensembl chr16:20,435,101...20,439,206
|
|
G |
Rabgap1 |
RAB GTPase activating protein 1 |
multiple interactions affects binding |
EXP |
manganese chloride inhibits the reaction [[RAB3A protein binds to Guanosine Triphosphate] which binds to RABGAP1 protein]; SNCA protein promotes the reaction [manganese chloride inhibits the reaction [[RAB3A protein binds to Guanosine Triphosphate] which binds to RABGAP1 protein]] |
CTD |
PMID:29289693 |
|
NCBI chr 3:21,698,032...21,815,383
Ensembl chr 3:21,698,032...21,815,379
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G |
Rac1 |
Rac family small GTPase 1 |
multiple interactions |
ISO EXP |
Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]; Zoledronic Acid results in increased expression of [RAC1 protein binds to Guanosine Triphosphate] Ethanol results in decreased expression of [RAC1 protein binds to Guanosine Triphosphate] CSF1 protein results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]; GGTI 298 results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]; mevastatin results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]; Risedronic Acid promotes the reaction [CSF1 protein results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]]; Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]; Zoledronic Acid results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein] |
CTD |
PMID:16734383 PMID:20829428 PMID:28871336 |
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NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
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G |
Rap1b |
RAP1B, member of RAS oncogene family |
multiple interactions |
ISO EXP |
[Pentoxifylline results in increased abundance of Cyclic AMP] results in increased abundance of [RAP1B protein binds to Guanosine Triphosphate] |
CTD |
PMID:21693435 |
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NCBI chr 7:60,850,406...60,878,226
Ensembl chr 7:60,853,930...60,860,990
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G |
Rasa1 |
RAS p21 protein activator 1 |
multiple interactions |
ISO |
KRAS protein mutant form inhibits the reaction [RASA1 protein promotes the reaction [KRAS protein results in increased hydrolysis of Guanosine Triphosphate]]; RASA1 protein promotes the reaction [KRAS protein results in increased hydrolysis of Guanosine Triphosphate] |
CTD |
PMID:28154176 |
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NCBI chr 2:13,617,021...13,696,531
Ensembl chr 2:13,616,822...13,696,426
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G |
Rhoa |
ras homolog family member A |
multiple interactions affects binding |
ISO |
Dronabinol inhibits the reaction [Guanosine Triphosphate binds to and results in increased activity of RHOA protein]; Guanosine Triphosphate binds to and results in increased activity of RHOA protein; Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]; Zoledronic Acid results in increased abundance of [Guanosine Triphosphate binds to RHOA protein] Asbestos, Crocidolite inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]; Cadmium Chloride promotes the reaction [RHOA protein binds to Guanosine Triphosphate]; Dronabinol inhibits the reaction [Guanosine Triphosphate binds to and results in increased activity of RHOA protein]; Guanosine Triphosphate binds to and results in increased activity of RHOA protein; Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]; tempol inhibits the reaction [Asbestos, Crocidolite inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]]; tempol inhibits the reaction [Vitamin K 3 inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]]; Vitamin K 3 inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]; Zoledronic Acid results in increased expression of [RHOA protein binds to Guanosine Triphosphate] |
CTD |
PMID:16734383 PMID:21257924 PMID:26220685 PMID:28871336 PMID:29307655 |
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NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
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G |
Snca |
synuclein alpha |
multiple interactions affects binding |
EXP |
manganese chloride promotes the reaction [SNCA protein binds to [RAB3A protein binds to Guanosine Triphosphate]]; SNCA protein promotes the reaction [manganese chloride inhibits the reaction [[RAB3A protein binds to Guanosine Triphosphate] which binds to RABGAP1 protein]] |
CTD |
PMID:29289693 |
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NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
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G |
Sos1 |
SOS Ras/Rac guanine nucleotide exchange factor 1 |
multiple interactions |
ISO |
[Enzyme Inhibitors binds to and results in decreased activity of SOS1 protein] inhibits the reaction [HRAS protein binds to Guanosine Triphosphate] |
CTD |
PMID:25825487 |
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NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
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G |
Tgm2 |
transglutaminase 2 |
affects binding |
ISO |
Guanosine Triphosphate binds to TGM2 protein |
CTD |
PMID:15556610 |
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NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
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G |
Adora2a |
adenosine A2a receptor |
multiple interactions |
ISO |
ADORA2A protein affects the reaction [[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein] which results in increased activity of Guanosine 5'-O-(3-Thiotriphosphate)] |
CTD |
PMID:14756803 |
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NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
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G |
Cnr2 |
cannabinoid receptor 2 |
multiple interactions affects binding |
ISO |
3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; 4-hydroxy-N-desmethyltamoxifen inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; afimoxifene inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; AM 281 inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; iodopravadoline inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; ridaifen-B inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; Tamoxifen inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein] |
CTD |
PMID:27936172 PMID:29906493 |
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NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
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G |
Gna13 |
G protein subunit alpha 13 |
affects binding multiple interactions |
ISO |
Guanosine 5'-O-(3-Thiotriphosphate) binds to GNA13 protein [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of GPR55 protein] affects the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to GNA13 protein] |
CTD |
PMID:17876302 |
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NCBI chr10:97,647,196...97,680,030
Ensembl chr10:97,647,111...97,684,730
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G |
Gpr55 |
G protein-coupled receptor 55 |
multiple interactions |
ISO |
[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of GPR55 protein] affects the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to GNA13 protein] |
CTD |
PMID:17876302 |
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NCBI chr 9:92,961,431...93,011,157
Ensembl chr 9:92,962,738...92,963,697
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G |
Hrh4 |
histamine receptor H4 |
affects binding multiple interactions |
ISO |
Guanosine 5'-O-(3-Thiotriphosphate) binds to HRH4 protein Histamine promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to HRH4 protein] |
CTD |
PMID:11181941 |
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NCBI chr18:4,365,429...4,382,599
Ensembl chr18:4,365,429...4,382,599
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G |
Myl9 |
myosin light chain 9 |
multiple interactions |
EXP |
[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased phosphorylation of MYL9 protein; Glycodeoxycholic Acid inhibits the reaction [[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased phosphorylation of MYL9 protein]; Y 27632 inhibits the reaction [[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased phosphorylation of MYL9 protein] |
CTD |
PMID:29660437 |
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NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
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G |
Oprm1 |
opioid receptor, mu 1 |
multiple interactions |
ISO |
[7-benzylidenenaltrexone binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate); [chlornaltrexamine binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate); [clocinnamox binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate) [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein] which results in increased activity of Guanosine 5'-O-(3-Thiotriphosphate); ADORA2A protein affects the reaction [[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein] which results in increased activity of Guanosine 5'-O-(3-Thiotriphosphate)] |
CTD |
PMID:11413242 PMID:14756803 |
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NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
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G |
Plcb1 |
phospholipase C beta 1 |
multiple interactions increases activity |
EXP |
[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein; Caffeine inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein]; Theophylline inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Theophylline inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein] |
CTD |
PMID:15998294 |
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NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
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G |
Plcg2 |
phospholipase C, gamma 2 |
multiple interactions |
ISO |
[[RAC2 protein co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCG2 protein] which results in increased chemical synthesis of Inositol Phosphates; [Guanosine 5'-O-(3-Thiotriphosphate) co-treated with RAC2 protein] promotes the reaction [PLCG2 protein mutant form results in increased chemical synthesis of Inositol Phosphates]; [Guanosine 5'-O-(3-Thiotriphosphate) co-treated with RAC2 protein] promotes the reaction [PLCG2 protein results in increased chemical synthesis of Inositol Phosphates]; [RAC2 protein co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCG2 protein; PLCG2 protein mutant form results in decreased susceptibility to [RAC2 protein co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] |
CTD |
PMID:25903139 PMID:27542411 |
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NCBI chr19:50,039,410...50,173,543
Ensembl chr19:50,045,020...50,173,220
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G |
Plek |
pleckstrin |
increases phosphorylation multiple interactions |
ISO |
Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein dioleoylphosphatidic acid analog promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein]; Oleic Acid promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein]; phosphatidylethanol analog promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein] |
CTD |
PMID:8928743 |
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NCBI chr14:100,151,518...100,184,192
Ensembl chr14:100,151,210...100,217,913
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G |
Ppp1r12a |
protein phosphatase 1, regulatory subunit 12A |
multiple interactions increases phosphorylation |
EXP |
Guanosine 5'-O-(3-Thiotriphosphate) inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased phosphorylation of PPP1R12A protein] Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PPP1R12A protein |
CTD |
PMID:29660437 |
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NCBI chr 7:51,404,971...51,515,382
Ensembl chr 7:51,404,919...51,515,373
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G |
Ptgdr |
prostaglandin D2 receptor |
multiple interactions |
ISO |
Guanosine 5'-O-(3-Thiotriphosphate) inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] |
CTD |
PMID:9579725 |
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NCBI chr15:19,195,606...19,196,508
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G |
Rac1 |
Rac family small GTPase 1 |
multiple interactions |
ISO |
Methohexital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]; Pentobarbital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]; Secobarbital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]; Thiamylal inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein] |
CTD |
PMID:15263067 |
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NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
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G |
Rac2 |
Rac family small GTPase 2 |
multiple interactions |
ISO |
[[RAC2 protein co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCG2 protein] which results in increased chemical synthesis of Inositol Phosphates; [Guanosine 5'-O-(3-Thiotriphosphate) co-treated with RAC2 protein] promotes the reaction [PLCG2 protein mutant form results in increased chemical synthesis of Inositol Phosphates]; [Guanosine 5'-O-(3-Thiotriphosphate) co-treated with RAC2 protein] promotes the reaction [PLCG2 protein results in increased chemical synthesis of Inositol Phosphates]; [RAC2 protein co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCG2 protein; PLCG2 protein mutant form results in decreased susceptibility to [RAC2 protein co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] |
CTD |
PMID:25903139 PMID:27542411 |
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NCBI chr 7:119,769,708...119,797,111
Ensembl chr 7:119,783,849...119,797,098
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G |
Rhoa |
ras homolog family member A |
affects localization multiple interactions |
EXP |
Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of RHOA protein [Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased localization of RHOA protein; Glycodeoxycholic Acid inhibits the reaction [[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased localization of RHOA protein]; Sevoflurane inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of RHOA protein] |
CTD |
PMID:12960549 PMID:29660437 |
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NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
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G |
Rock2 |
Rho-associated coiled-coil containing protein kinase 2 |
affects localization multiple interactions |
EXP |
Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of ROCK2 protein sevoflurane inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of ROCK2 protein] |
CTD |
PMID:12960549 |
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NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
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G |
Trpc6 |
transient receptor potential cation channel, subfamily C, member 6 |
increases activity |
ISO |
Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of TRPC6 protein |
CTD |
PMID:11179201 |
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NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
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