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ONTOLOGY REPORT - ANNOTATIONS


Term:cimetidine
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Accession:CHEBI:3699 term browser browse the term
Definition:A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Synonyms:exact_synonym: 2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine
 related_synonym: 1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine;   2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine;   Cimetag;   Formula=C10H16N6S;   InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14);   InChIKey=AQIXAKUUQRKLND-UHFFFAOYSA-N;   N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine;   N-cyano-N'-methyl-N''-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidine;   SMILES=CN\\C(NCCSCc1nc[nH]c1C)=N\\C#N;   Tagamet HB 200;   Ulcerfen;   cimetidina;   cimetidinum
 xref: CAS:51481-61-9 "ChemIDplus";   CAS:51481-61-9 "KEGG COMPOUND";   CAS:51481-61-9 "NIST Chemistry WebBook";   DrugBank:DB00501;   Drug_Central:645 "DrugCentral";   HMDB:HMDB0014644;   KEGG:D00295;   LINCS:LSM-2404
 xref_mesh: MESH:D002927
 xref: PMID:11910267 "Europe PMC";   PMID:15637527 "Europe PMC";   PMID:7229121 "Europe PMC";   Patent:BE804144;   Patent:US3950333;   Reaxys:6516325 "Reaxys";   VSDB:1892;   Wikipedia:Cimetidine


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cimetidine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Adh1 alcohol dehydrogenase 1 (class I) JBrowse link 2 243,550,655 243,562,243 RGD:6480464
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide JBrowse link 2 243,702,035 243,720,063 RGD:6480464
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide JBrowse link 2 243,728,500 243,740,907 RGD:6480464
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide JBrowse link 2 243,500,540 243,516,865 RGD:6480464
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 JBrowse link 1 238,222,689 238,264,381 RGD:6480464
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 JBrowse link 10 47,490,168 47,499,855 RGD:6480464
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:6480464
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:6480464
G Cst3 cystatin C JBrowse link 3 143,219,671 143,223,544 RGD:6480464
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:6480464
G Ctsl cathepsin L JBrowse link 17 1,873,105 1,879,266 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 JBrowse link 1 257,676,172 258,004,428 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 JBrowse link 5 119,546,458 119,564,843 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Fshb follicle stimulating hormone subunit beta JBrowse link 3 98,088,321 98,092,131 RGD:6480464
G Gast gastrin JBrowse link 10 88,245,532 88,248,485 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hrh1 histamine receptor H 1 JBrowse link 4 146,374,596 146,458,148 RGD:6480464
G Hrh2 histamine receptor H 2 JBrowse link 17 10,912,959 10,931,389 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il16 interleukin 16 JBrowse link 1 145,781,923 145,881,538 RGD:6480464
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:6480464
G Itgax integrin subunit alpha X JBrowse link 1 199,555,560 199,576,948 RGD:6480464
G Lrp1 LDL receptor related protein 1 JBrowse link 7 70,846,313 70,927,028 RGD:6480464
G Ncam1 neural cell adhesion molecule 1 JBrowse link 8 53,836,797 54,134,881 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464
G Ntf3 neurotrophin 3 JBrowse link 4 158,636,883 158,705,886 RGD:6480464
G Pde4b phosphodiesterase 4B JBrowse link 5 121,759,236 122,136,814 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464
G Prok1 prokineticin 1 JBrowse link 2 209,986,503 209,994,438 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:6480464
G Slc22a1 solute carrier family 22 member 1 JBrowse link 1 48,273,639 48,300,645 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc22a3 solute carrier family 22 member 3 JBrowse link 1 48,433,079 48,521,261 RGD:6480464
G Slc22a6 solute carrier family 22 member 6 JBrowse link 1 224,824,809 224,833,284 RGD:6480464
G Slc22a7 solute carrier family 22 member 7 JBrowse link 9 16,925,321 16,931,119 RGD:6480464
G Slc22a8 solute carrier family 22 member 8 JBrowse link 1 224,799,444 224,818,482 RGD:6480464
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:6480464
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:6480464
G Slc9a3 solute carrier family 9 member A3 JBrowse link 1 31,731,652 31,777,144 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        pharmacological role 18684
          analgesic 13037
            cimetidine 68
              cimetidine S-oxide 0
              cimetidine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  heteroarene 15146
                                    monocyclic heteroarene 11614
                                      azole 10473
                                        diazole 8040
                                          imidazoles 7591
                                            cimetidine 68
                                              cimetidine S-oxide 0
                                              cimetidine hydrochloride 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.