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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbonothioic acid
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Accession:CHEBI:36960 term browser browse the term
Synonyms:related_synonym: Formula=CH2O2S;   H2CO2S;   thiocarbonic acid



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N-phenylthiourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CA1 carbonic anhydrase 1 decreases activity EXP Phenylthiourea analog results in decreased activity of CA1 protein CTD PMID:30291660 NCBI chr 8:85,327,608...85,378,113
Ensembl chr 8:85,327,608...85,379,014
JBrowse link
G CA2 carbonic anhydrase 2 decreases activity EXP Phenylthiourea analog results in decreased activity of CA2 protein CTD PMID:30291660 NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493
JBrowse link
G CASP9 caspase 9 increases expression EXP Phenylthiourea results in increased expression of CASP9 protein CTD PMID:16447258 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G FMO3 flavin containing dimethylaniline monoxygenase 3 increases response to substance EXP FMO3 protein results in increased susceptibility to Phenylthiourea CTD PMID:12093470 NCBI chr 1:171,090,873...171,117,819
Ensembl chr 1:171,090,901...171,117,819
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Phenylthiourea results in decreased expression of FOS protein CTD PMID:18003792 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation ISO Phenylthiourea results in increased phosphorylation of MAPK1 protein CTD PMID:26051519 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation ISO Phenylthiourea results in increased phosphorylation of MAPK3 protein CTD PMID:26051519 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MITF melanocyte inducing transcription factor increases expression ISO Phenylthiourea results in increased expression of MITF protein CTD PMID:26051519 NCBI chr 3:69,739,464...69,968,332
Ensembl chr 3:69,739,464...69,968,336
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha increases expression EXP Phenylthiourea results in increased expression of PPARA protein CTD PMID:16447258 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit increases expression EXP Phenylthiourea results in increased expression of RELA protein CTD PMID:16447258 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G TAS2R38 taste 2 receptor member 38 affects response to substance
affects activity
increases activity
multiple interactions
EXP TAS2R38 gene polymorphism affects the susceptibility to Phenylthiourea
Phenylthiourea affects the activity of TAS2R38
Phenylthiourea results in increased activity of TAS2R38 protein
4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]; Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]
CTD PMID:17684414 PMID:21629661 PMID:22384968 NCBI chr 7:141,972,631...141,973,773
Ensembl chr 7:141,972,631...141,973,773
JBrowse link
thiourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein increases uptake ISO Thiourea results in increased uptake of APP protein modified form CTD PMID:20637185 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AQP1 aquaporin 1 (Colton blood group) decreases expression ISO Thiourea results in decreased expression of AQP1 mRNA CTD PMID:15248066 NCBI chr 7:30,911,853...30,925,516
Ensembl chr 7:30,911,853...30,925,517
JBrowse link
G AQP3 aquaporin 3 (Gill blood group) increases expression ISO Thiourea results in increased expression of AQP3 mRNA CTD PMID:15248066 NCBI chr 9:33,441,154...33,447,596
Ensembl chr 9:33,441,156...33,447,596
JBrowse link
G AQP4 aquaporin 4 decreases expression ISO Thiourea results in decreased expression of AQP4 mRNA CTD PMID:15248066 NCBI chr18:26,852,038...26,865,803
Ensembl chr18:26,852,043...26,865,771
JBrowse link
G AQP5 aquaporin 5 decreases expression ISO Thiourea results in decreased expression of AQP5 mRNA CTD PMID:15248066 NCBI chr12:49,961,855...49,965,682
Ensembl chr12:49,961,872...49,965,682
JBrowse link
G AQP9 aquaporin 9 increases uptake ISO AQP9 protein results in increased uptake of Thiourea CTD PMID:9733774 NCBI chr15:58,138,169...58,185,911
Ensembl chr15:58,138,169...58,185,911
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein] CTD PMID:29803612 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G CA1 carbonic anhydrase 1 decreases activity EXP Thiourea analog results in decreased activity of CA1 protein CTD PMID:28117934 NCBI chr 8:85,327,608...85,378,113
Ensembl chr 8:85,327,608...85,379,014
JBrowse link
G CA2 carbonic anhydrase 2 decreases activity EXP Thiourea analog results in decreased activity of CA2 protein CTD PMID:28117934 NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493
JBrowse link
G CASP3 caspase 3 multiple interactions ISO
EXP
Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]
Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]
CTD PMID:14599462 PMID:29803612 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CFTR CF transmembrane conductance regulator decreases expression ISO Thiourea results in decreased expression of CFTR mRNA CTD PMID:15248066 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Thiourea inhibits the reaction [cadmium acetate results in increased secretion of CXCL8 protein]; Thiourea inhibits the reaction [Particulate Matter results in increased expression of CXCL8 mRNA]; Thiourea inhibits the reaction [sodium arsenite results in increased secretion of CXCL8 protein]; Thiourea inhibits the reaction [Vehicle Emissions results in increased expression of CXCL8 mRNA]; Thiourea inhibits the reaction [zinc chloride results in increased secretion of CXCL8 protein] CTD PMID:26160521 PMID:27427241 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G FMO2 flavin containing dimethylaniline monoxygenase 2 increases metabolic processing EXP FMO2 protein results in increased metabolism of Thiourea CTD PMID:12214664 NCBI chr 1:171,185,208...171,212,686
Ensembl chr 1:171,185,249...171,212,686
JBrowse link
G FMO3 flavin containing dimethylaniline monoxygenase 3 multiple interactions
increases response to substance
EXP Buthionine Sulfoximine inhibits the reaction [FMO3 protein results in increased susceptibility to Thiourea] CTD PMID:12093470 NCBI chr 1:171,090,873...171,117,819
Ensembl chr 1:171,090,901...171,117,819
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA] CTD PMID:15105052 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein] CTD PMID:19931295 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,364,001
JBrowse link
G IFNG interferon gamma multiple interactions ISO Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]] CTD PMID:10868913 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Thiourea inhibits the reaction [cadmium acetate results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [sodium arsenite results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Vehicle Emissions results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [zinc chloride results in increased secretion of IL6 protein] CTD PMID:26160521 PMID:27427241 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of JUN mRNA] CTD PMID:15105052 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G NOS2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO Thiourea analog results in decreased expression of NOS2 mRNA; Thiourea analog results in decreased expression of NOS2 protein; Thiourea results in decreased expression of NOS2 protein
[Thiourea analog results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:17467989 PMID:20637185 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO Thiourea results in decreased expression of PTGS2 protein
Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD PMID:20637185 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G SCNN1A sodium channel epithelial 1 subunit alpha decreases expression ISO Thiourea results in decreased expression of SCNN1A mRNA CTD PMID:15248066 NCBI chr12:6,346,847...6,377,359
Ensembl chr12:6,346,843...6,377,730
JBrowse link
G SCNN1B sodium channel epithelial 1 subunit beta decreases expression ISO Thiourea results in decreased expression of SCNN1B mRNA CTD PMID:15248066 NCBI chr16:23,278,231...23,381,295
Ensembl chr16:23,278,231...23,381,294
JBrowse link
G SCNN1G sodium channel epithelial 1 subunit gamma decreases expression ISO Thiourea results in decreased expression of SCNN1G mRNA CTD PMID:15248066 NCBI chr16:23,182,745...23,216,883
Ensembl chr16:23,182,745...23,216,883
JBrowse link
G SLC14A1 solute carrier family 14 member 1 (Kidd blood group) multiple interactions ISO Thiourea inhibits the reaction [SLC14A1 protein affects the transport of Urea] CTD PMID:17506977 NCBI chr18:45,724,127...45,752,520
Ensembl chr18:45,687,025...45,752,520
JBrowse link
G SLC14A2 solute carrier family 14 member 2 multiple interactions ISO Thiourea analog inhibits the reaction [SLC14A2 protein results in increased transport of Urea] CTD PMID:11181411 NCBI chr18:45,167,963...45,683,688
Ensembl chr18:45,212,995...45,683,688
JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions ISO Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]] CTD PMID:10868913 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein] CTD PMID:29803612 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24838
    role 24759
      chemical role 23138
        acid 22237
          Bronsted acid 22235
            oxoacid 22175
              carbon oxoacid 21963
                carbonothioic acid 35
                  carbonothioic O,O-acid + 35
                  carbonothioic O,S-acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24838
    subatomic particle 24799
      composite particle 24799
        hadron 24799
          baryon 24799
            nucleon 24799
              atomic nucleus 24799
                atom 24799
                  main group element atom 24668
                    p-block element atom 24668
                      carbon group element atom 24465
                        carbon atom 24429
                          organic molecular entity 24429
                            heteroorganic entity 23830
                              organochalcogen compound 23399
                                organooxygen compound 23247
                                  carbon oxoacid 21963
                                    carbonothioic acid 35
                                      carbonothioic O,O-acid + 35
                                      carbonothioic O,S-acid 0
paths to the root