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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbonothioic acid
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Accession:CHEBI:36960 term browser browse the term
Synonyms:related_synonym: Formula=CH2O2S;   H2CO2S;   thiocarbonic acid


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N-phenylthiourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 decreases activity ISO Phenylthiourea analog results in decreased activity of CA1 protein CTD PMID:30291660 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Phenylthiourea analog results in decreased activity of CA2 protein CTD PMID:30291660 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp9 caspase 9 increases expression ISO Phenylthiourea results in increased expression of CASP9 protein CTD PMID:16447258 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases response to substance ISO FMO3 protein results in increased susceptibility to Phenylthiourea CTD PMID:12093470 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Phenylthiourea results in decreased expression of FOS protein CTD PMID:18003792 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Phenylthiourea results in increased phosphorylation of MAPK1 protein CTD PMID:26051519 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Phenylthiourea results in increased phosphorylation of MAPK3 protein CTD PMID:26051519 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mitf melanocyte inducing transcription factor increases expression ISO Phenylthiourea results in increased expression of MITF protein CTD PMID:26051519 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Phenylthiourea results in increased expression of PPARA protein CTD PMID:16447258 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Phenylthiourea results in increased expression of RELA protein CTD PMID:16447258 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tas2r138 taste receptor, type 2, member 138 affects response to substance
multiple interactions
increases activity
affects activity
ISO TAS2R38 gene polymorphism affects the susceptibility to Phenylthiourea
4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]; Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]
Phenylthiourea affects the activity of TAS2R38
CTD PMID:17684414 PMID:21629661 PMID:22384968 NCBI chr 4:69,428,344...69,429,339
Ensembl chr 4:69,428,344...69,429,339
JBrowse link
thiourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein increases uptake ISO Thiourea results in increased uptake of APP protein modified form CTD PMID:20637185 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp1 aquaporin 1 decreases expression EXP Thiourea results in decreased expression of AQP1 mRNA CTD PMID:15248066 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression EXP Thiourea results in increased expression of AQP3 mRNA CTD PMID:15248066 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Aqp4 aquaporin 4 decreases expression EXP Thiourea results in decreased expression of AQP4 mRNA CTD PMID:15248066 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Aqp5 aquaporin 5 decreases expression EXP Thiourea results in decreased expression of AQP5 mRNA CTD PMID:15248066 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
JBrowse link
G Aqp9 aquaporin 9 increases uptake EXP AQP9 protein results in increased uptake of Thiourea CTD PMID:9733774 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein] CTD PMID:29803612 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Thiourea analog results in decreased activity of CA1 protein CTD PMID:28117934 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Thiourea analog results in decreased activity of CA2 protein CTD PMID:28117934 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]
Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]
CTD PMID:14599462 PMID:29803612 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cftr CF transmembrane conductance regulator decreases expression EXP Thiourea results in decreased expression of CFTR mRNA CTD PMID:15248066 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases metabolic processing ISO FMO2 protein results in increased metabolism of Thiourea CTD PMID:12214664 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 multiple interactions
increases response to substance
ISO Buthionine Sulfoximine inhibits the reaction [FMO3 protein results in increased susceptibility to Thiourea] CTD PMID:12093470 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA] CTD PMID:15105052 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein] CTD PMID:19931295 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Ifng interferon gamma multiple interactions ISO Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]] CTD PMID:10868913 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Thiourea inhibits the reaction [cadmium acetate results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [sodium arsenite results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Vehicle Emissions results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [zinc chloride results in increased secretion of IL6 protein] CTD PMID:26160521 PMID:27427241 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of JUN mRNA] CTD PMID:15105052 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO Thiourea analog results in decreased expression of NOS2 mRNA; Thiourea analog results in decreased expression of NOS2 protein; Thiourea results in decreased expression of NOS2 protein
[Thiourea analog results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:17467989 PMID:20637185 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO Thiourea results in decreased expression of PTGS2 protein
Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD PMID:20637185 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha decreases expression EXP Thiourea results in decreased expression of SCNN1A mRNA CTD PMID:15248066 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta decreases expression EXP Thiourea results in decreased expression of SCNN1B mRNA CTD PMID:15248066 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma decreases expression EXP Thiourea results in decreased expression of SCNN1G mRNA CTD PMID:15248066 NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816
JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) multiple interactions ISO Thiourea inhibits the reaction [SLC14A1 protein affects the transport of Urea] CTD PMID:17506977 NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146
JBrowse link
G Slc14a2 solute carrier family 14 member 2 multiple interactions EXP Thiourea analog inhibits the reaction [SLC14A2 protein results in increased transport of Urea] CTD PMID:11181411 NCBI chr18:71,612,460...72,039,462
Ensembl chr18:71,612,460...71,792,968
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]] CTD PMID:10868913 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein] CTD PMID:29803612 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      chemical role 19345
        acid 18541
          Bronsted acid 18537
            oxoacid 18498
              carbon oxoacid 18378
                carbonothioic acid 34
                  carbonothioic O,O-acid + 34
                  carbonothioic O,S-acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            heteroorganic entity 19294
                              organochalcogen compound 19064
                                organooxygen compound 19014
                                  carbon oxoacid 18378
                                    carbonothioic acid 34
                                      carbonothioic O,O-acid + 34
                                      carbonothioic O,S-acid 0
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