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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thiourea
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Accession:CHEBI:36946 term browser browse the term
Definition:The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.
Synonyms:related_synonym: 2-thiourea;   Formula=CH4N2S;   H2NC(S)NH2;   InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4);   InChIKey=UMGDCJDMYOKAJW-UHFFFAOYSA-N;   SMILES=NC(N)=S;   Thiocarbamid;   Thioharnstoff;   Thiokarbamid;   aminothioamide;   aminothiocarboxamide;   carbonothioic diamide;   thiocarbamide;   thiocarbonic acid diamide;   tu
 alt_id: CHEBI:29331;   CHEBI:35015;   CHEBI:46065
 xref: Beilstein:605327;   CAS:62-56-6;   Gmelin:1604;   KEGG:C14415
 xref_mesh: MESH:D013890
 xref: PDBeChem:TOU;   PMID:12102173;   PPDB:641;   Patent:US2173067;   Patent:US2357149;   Patent:US2393917;   Patent:US2552584;   Patent:US2560596;   Reaxys:605327;   Wikipedia:Thiourea

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thiourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein increases uptake ISO Thiourea results in increased uptake of APP protein modified form CTD PMID:20637185 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Aqp1 aquaporin 1 decreases expression EXP Thiourea results in decreased expression of AQP1 mRNA CTD PMID:15248066 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression EXP Thiourea results in increased expression of AQP3 mRNA CTD PMID:15248066 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245 		JBrowse link
G Aqp4 aquaporin 4 decreases expression EXP Thiourea results in decreased expression of AQP4 mRNA CTD PMID:15248066 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996 		JBrowse link
G Aqp5 aquaporin 5 decreases expression EXP Thiourea results in decreased expression of AQP5 mRNA CTD PMID:15248066 NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578 		JBrowse link
G Aqp9 aquaporin 9 increases uptake EXP AQP9 protein results in increased uptake of Thiourea CTD PMID:9733774 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein] CTD PMID:29803612 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Thiourea analog results in decreased activity of CA1 protein CTD PMID:28117934 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Thiourea analog results in decreased activity of CA2 protein CTD PMID:28117934 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]
Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]		 CTD PMID:14599462 PMID:29803612 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cftr CF transmembrane conductance regulator decreases expression EXP Thiourea results in decreased expression of CFTR mRNA CTD PMID:15248066 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases metabolic processing ISO FMO2 protein results in increased metabolism of Thiourea CTD PMID:12214664 NCBI chr13:80,752,526...80,775,264
Ensembl chr13:80,755,058...80,775,264 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 multiple interactions
increases response to substance		 ISO Buthionine Sulfoximine inhibits the reaction [FMO3 protein results in increased susceptibility to Thiourea] CTD PMID:12093470 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA] CTD PMID:15105052 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein] CTD PMID:19931295 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]] CTD PMID:10868913 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Thiourea inhibits the reaction [cadmium acetate results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [sodium arsenite results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Vehicle Emissions results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [zinc chloride results in increased secretion of IL6 protein] CTD PMID:26160521 PMID:27427241 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of JUN mRNA] CTD PMID:15105052 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 ISO Thiourea analog results in decreased expression of NOS2 mRNA; Thiourea analog results in decreased expression of NOS2 protein; Thiourea results in decreased expression of NOS2 protein
[Thiourea analog results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of NOS2 protein]		 CTD PMID:17467989 PMID:20637185 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions		 ISO Thiourea results in decreased expression of PTGS2 protein
Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of PTGS2 protein]		 CTD PMID:20637185 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha decreases expression EXP Thiourea results in decreased expression of SCNN1A mRNA CTD PMID:15248066 NCBI chr 4:157,834,339...157,860,472
Ensembl chr 4:157,836,912...157,860,049 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta decreases expression EXP Thiourea results in decreased expression of SCNN1B mRNA CTD PMID:15248066 NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298 		JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma decreases expression EXP Thiourea results in decreased expression of SCNN1G mRNA CTD PMID:15248066 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268 		JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) multiple interactions ISO Thiourea inhibits the reaction [SLC14A1 protein affects the transport of Urea] CTD PMID:17506977 NCBI chr18:74,461,064...74,504,475
Ensembl chr18:74,461,055...74,485,139 		JBrowse link
G Slc14a2 solute carrier family 14 member 2 multiple interactions EXP Thiourea analog inhibits the reaction [SLC14A2 protein results in increased transport of Urea] CTD PMID:11181411 NCBI chr18:74,508,070...74,941,389
Ensembl chr18:74,546,220...74,688,551
Ensembl chr18:74,546,220...74,688,551 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]] CTD PMID:10868913 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein] CTD PMID:29803612 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
N-phenylthiourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 decreases activity ISO Phenylthiourea analog results in decreased activity of CA1 protein CTD PMID:30291660 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Phenylthiourea analog results in decreased activity of CA2 protein CTD PMID:30291660 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G Casp9 caspase 9 increases expression ISO Phenylthiourea results in increased expression of CASP9 protein CTD PMID:16447258 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases response to substance ISO FMO3 protein results in increased susceptibility to Phenylthiourea CTD PMID:12093470 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Phenylthiourea results in decreased expression of FOS protein CTD PMID:18003792 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Phenylthiourea results in increased phosphorylation of MAPK1 protein CTD PMID:26051519 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Phenylthiourea results in increased phosphorylation of MAPK3 protein CTD PMID:26051519 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mitf melanocyte inducing transcription factor increases expression ISO Phenylthiourea results in increased expression of MITF protein CTD PMID:26051519 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Phenylthiourea results in increased expression of PPARA protein CTD PMID:16447258 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Phenylthiourea results in increased expression of RELA protein CTD PMID:16447258 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tas2r138 taste receptor, type 2, member 138 affects response to substance
multiple interactions
increases activity
affects activity		 ISO TAS2R38 gene polymorphism affects the susceptibility to Phenylthiourea
4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]; Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]
Phenylthiourea affects the activity of TAS2R38		 CTD PMID:17684414 PMID:21629661 PMID:22384968 NCBI chr 4:68,831,221...68,832,216
Ensembl chr 4:68,831,221...68,832,216 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      chemical role 19262
        antioxidant 14276
          thiourea 34
            (4-bromophenyl)thiourea 0
            N-phenylthiourea 11
            allylthiourea 0
            carbamothioyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic group 18613
                              organic divalent group 18604
                                organodiyl group 18604
                                  carbonyl group 18521
                                    carbonyl compound 18521
                                      carboxylic acid 18196
                                        carboacyl group 17418
                                          univalent carboacyl group 17418
                                            carbamoyl group 17218
                                              carboxamide 17218
                                                monocarboxylic acid amide 14635
                                                  urea 5098
                                                    ureas 5095
                                                      thiourea 34
                                                        (4-bromophenyl)thiourea 0
                                                        N-phenylthiourea 11
                                                        allylthiourea 0
                                                        carbamothioyl group 0
paths to the root