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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thiourea
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Accession:CHEBI:36946 term browser browse the term
Definition:The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.
Synonyms:related_synonym: 2-thiourea;   Formula=CH4N2S;   H2NC(S)NH2;   InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4);   InChIKey=UMGDCJDMYOKAJW-UHFFFAOYSA-N;   SMILES=NC(N)=S;   Thiocarbamid;   Thioharnstoff;   Thiokarbamid;   aminothioamide;   aminothiocarboxamide;   carbonothioic diamide;   thiocarbamide;   thiocarbonic acid diamide;   tu
 alt_id: CHEBI:29331;   CHEBI:35015;   CHEBI:46065
 xref: CAS:62-56-6;   Gmelin:1604;   KEGG:C14415
 xref_mesh: MESH:D013890
 xref: PDBeChem:TOU;   PMID:12102173;   PPDB:641;   Patent:US2173067;   Patent:US2357149;   Patent:US2393917;   Patent:US2552584;   Patent:US2560596;   Reaxys:605327;   Wikipedia:Thiourea


show annotations for term's descendants           Sort by:
thiourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein increases uptake ISO Thiourea results in increased uptake of APP protein modified form CTD PMID:20637185 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Aqp1 aquaporin 1 decreases expression EXP Thiourea results in decreased expression of AQP1 mRNA CTD PMID:15248066 NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression EXP Thiourea results in increased expression of AQP3 mRNA CTD PMID:15248066 NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:61,035,166...61,040,685 		JBrowse link
G Aqp4 aquaporin 4 decreases expression EXP Thiourea results in decreased expression of AQP4 mRNA CTD PMID:15248066 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098 		JBrowse link
G Aqp5 aquaporin 5 decreases expression EXP Thiourea results in decreased expression of AQP5 mRNA CTD PMID:15248066 NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:132,601,059...132,605,062 		JBrowse link
G Aqp9 aquaporin 9 increases uptake EXP AQP9 protein results in increased uptake of Thiourea CTD PMID:9733774 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein] CTD PMID:29803612 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Ca1 carbonic anhydrase 1 decreases activity ISO Thiourea analog results in decreased activity of CA1 protein CTD PMID:28117934 NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Thiourea analog results in decreased activity of CA2 protein CTD PMID:28117934 NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO 		Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]
Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein] 		CTD PMID:14599462 PMID:29803612 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cftr CF transmembrane conductance regulator decreases expression EXP Thiourea results in decreased expression of CFTR mRNA CTD PMID:15248066 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases metabolic processing ISO FMO2 protein results in increased metabolism of Thiourea CTD PMID:12214664 NCBI chr13:77,755,131...77,777,597
Ensembl chr13:77,757,629...77,777,534 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 multiple interactions
increases response to substance 		ISO Buthionine Sulfoximine inhibits the reaction [FMO3 protein results in increased susceptibility to Thiourea] CTD PMID:12093470 NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA] CTD PMID:15105052 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein] CTD PMID:19931295 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]] CTD PMID:10868913 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Thiourea inhibits the reaction [cadmium acetate results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [sodium arsenite results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Vehicle Emissions results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [zinc chloride results in increased secretion of IL6 protein] CTD PMID:26160521 PMID:27427241 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of JUN mRNA] CTD PMID:15105052 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions 		ISO Thiourea analog results in decreased expression of NOS2 mRNA; Thiourea analog results in decreased expression of NOS2 protein; Thiourea results in decreased expression of NOS2 protein
[Thiourea analog results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of NOS2 protein] 		CTD PMID:17467989 PMID:20637185 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions 		ISO Thiourea results in decreased expression of PTGS2 protein
Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of PTGS2 protein] 		CTD PMID:20637185 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha decreases expression EXP Thiourea results in decreased expression of SCNN1A mRNA CTD PMID:15248066 NCBI chr 4:159,809,187...159,832,409
Ensembl chr 4:159,809,170...159,832,405 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta decreases expression EXP Thiourea results in decreased expression of SCNN1B mRNA CTD PMID:15248066 NCBI chr 1:185,861,326...185,915,717
Ensembl chr 1:185,854,733...185,916,049 		JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma decreases expression EXP Thiourea results in decreased expression of SCNN1G mRNA CTD PMID:15248066 NCBI chr 1:185,736,225...185,770,099
Ensembl chr 1:185,736,191...185,770,097 		JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) multiple interactions ISO Thiourea inhibits the reaction [SLC14A1 protein affects the transport of Urea] CTD PMID:17506977 NCBI chr18:73,840,568...73,883,925
Ensembl chr18:73,840,569...73,870,489 		JBrowse link
G Slc14a2 solute carrier family 14 member 2 multiple interactions EXP Thiourea analog inhibits the reaction [SLC14A2 protein results in increased transport of Urea] CTD PMID:11181411 Ensembl chr18:73,887,575...73,953,570 JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]] CTD PMID:10868913 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein] CTD PMID:29803612 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
N-phenylthiourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca1 carbonic anhydrase 1 decreases activity ISO Phenylthiourea analog results in decreased activity of CA1 protein CTD PMID:30291660 NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Phenylthiourea analog results in decreased activity of CA2 protein CTD PMID:30291660 NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064 		JBrowse link
G Casp9 caspase 9 increases expression ISO Phenylthiourea results in increased expression of CASP9 protein CTD PMID:16447258 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases response to substance ISO FMO3 protein results in increased susceptibility to Phenylthiourea CTD PMID:12093470 NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Phenylthiourea results in decreased expression of FOS protein CTD PMID:18003792 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Phenylthiourea results in increased phosphorylation of MAPK1 protein CTD PMID:26051519 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Phenylthiourea results in increased phosphorylation of MAPK3 protein CTD PMID:26051519 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mitf melanocyte inducing transcription factor increases expression ISO Phenylthiourea results in increased expression of MITF protein CTD PMID:26051519 NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:131,965,714...132,177,790 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Phenylthiourea results in increased expression of PPARA protein CTD PMID:16447258 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Phenylthiourea results in increased expression of RELA protein CTD PMID:16447258 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tas2r138 taste receptor, type 2, member 138 affects response to substance
multiple interactions
increases activity
affects activity 		ISO TAS2R38 gene polymorphism affects the susceptibility to Phenylthiourea
4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]; Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]
Phenylthiourea affects the activity of TAS2R38 		CTD PMID:17684414 PMID:21629661 PMID:22384968 NCBI chr 4:70,395,042...70,396,037 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      chemical role 20396
        antioxidant 16464
          thiourea 34
            (4-bromophenyl)thiourea 0
            N-acetylthiourea 0
            N-ethylthiourea 0
            N-methylthiourea 0
            N-phenylthiourea 11
            allylthiourea 0
            carbamothioyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      carboacyl group 18085
                                        univalent carboacyl group 18085
                                          carbamoyl group 17921
                                            carboxamide 17921
                                              monocarboxylic acid amide 15953
                                                urea 6336
                                                  ureas 6334
                                                    thiourea 34
                                                      (4-bromophenyl)thiourea 0
                                                      N-acetylthiourea 0
                                                      N-ethylthiourea 0
                                                      N-methylthiourea 0
                                                      N-phenylthiourea 11
                                                      allylthiourea 0
                                                      carbamothioyl group 0
paths to the root