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G
|
App
|
amyloid beta precursor protein
|
increases uptake
|
ISO
|
Thiourea results in increased uptake of APP protein modified form
|
CTD |
PMID:20637185 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
|
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G
|
Aqp1
|
aquaporin 1
|
decreases expression
|
EXP
|
Thiourea results in decreased expression of AQP1 mRNA
|
CTD |
PMID:15248066 |
|
NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504
|
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G
|
Aqp3
|
aquaporin 3 (Gill blood group)
|
increases expression
|
EXP
|
Thiourea results in increased expression of AQP3 mRNA
|
CTD |
PMID:15248066 |
|
NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:61,035,166...61,040,685
|
|
G
|
Aqp4
|
aquaporin 4
|
decreases expression
|
EXP
|
Thiourea results in decreased expression of AQP4 mRNA
|
CTD |
PMID:15248066 |
|
NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098
|
|
G
|
Aqp5
|
aquaporin 5
|
decreases expression
|
EXP
|
Thiourea results in decreased expression of AQP5 mRNA
|
CTD |
PMID:15248066 |
|
NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:132,601,059...132,605,062
|
|
G
|
Aqp9
|
aquaporin 9
|
increases uptake
|
EXP
|
AQP9 protein results in increased uptake of Thiourea
|
CTD |
PMID:9733774 |
|
NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
multiple interactions
|
ISO
|
Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein]
|
CTD |
PMID:29803612 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
|
|
G
|
Ca1
|
carbonic anhydrase 1
|
decreases activity
|
ISO
|
Thiourea analog results in decreased activity of CA1 protein
|
CTD |
PMID:28117934 |
|
NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454
|
|
G
|
Car2
|
carbonic anhydrase 2
|
decreases activity
|
ISO
|
Thiourea analog results in decreased activity of CA2 protein
|
CTD |
PMID:28117934 |
|
NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
EXP ISO
|
Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein] Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]
|
CTD |
PMID:14599462 PMID:29803612 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Cftr
|
CF transmembrane conductance regulator
|
decreases expression
|
EXP
|
Thiourea results in decreased expression of CFTR mRNA
|
CTD |
PMID:15248066 |
|
NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643
|
|
G
|
Fmo2
|
flavin containing dimethylaniline monoxygenase 2
|
increases metabolic processing
|
ISO
|
FMO2 protein results in increased metabolism of Thiourea
|
CTD |
PMID:12214664 |
|
NCBI chr13:77,755,131...77,777,597
Ensembl chr13:77,757,629...77,777,534
|
|
G
|
Fmo3
|
flavin containing dimethylaniline monoxygenase 3
|
multiple interactions increases response to substance
|
ISO
|
Buthionine Sulfoximine inhibits the reaction [FMO3 protein results in increased susceptibility to Thiourea]
|
CTD |
PMID:12093470 |
|
NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256
|
|
G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
ISO
|
Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA]
|
CTD |
PMID:15105052 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
|
|
G
|
Hmgcr
|
3-hydroxy-3-methylglutaryl-CoA reductase
|
multiple interactions
|
EXP
|
Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein]
|
CTD |
PMID:19931295 |
|
NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533
|
|
G
|
Ifng
|
interferon gamma
|
multiple interactions
|
ISO
|
Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]]
|
CTD |
PMID:10868913 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
Thiourea inhibits the reaction [cadmium acetate results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [sodium arsenite results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Vehicle Emissions results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [zinc chloride results in increased secretion of IL6 protein]
|
CTD |
PMID:26160521 PMID:27427241 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Jun
|
Jun proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
ISO
|
Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of JUN mRNA]
|
CTD |
PMID:15105052 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
decreases expression multiple interactions
|
ISO
|
Thiourea analog results in decreased expression of NOS2 mRNA; Thiourea analog results in decreased expression of NOS2 protein; Thiourea results in decreased expression of NOS2 protein [Thiourea analog results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of NOS2 protein]
|
CTD |
PMID:17467989 PMID:20637185 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
decreases expression multiple interactions
|
ISO
|
Thiourea results in decreased expression of PTGS2 protein Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of PTGS2 protein]
|
CTD |
PMID:20637185 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
|
|
G
|
Scnn1a
|
sodium channel epithelial 1 subunit alpha
|
decreases expression
|
EXP
|
Thiourea results in decreased expression of SCNN1A mRNA
|
CTD |
PMID:15248066 |
|
NCBI chr 4:159,809,187...159,832,409
Ensembl chr 4:159,809,170...159,832,405
|
|
G
|
Scnn1b
|
sodium channel epithelial 1 subunit beta
|
decreases expression
|
EXP
|
Thiourea results in decreased expression of SCNN1B mRNA
|
CTD |
PMID:15248066 |
|
NCBI chr 1:185,861,326...185,915,717
Ensembl chr 1:185,854,733...185,916,049
|
|
G
|
Scnn1g
|
sodium channel epithelial 1 subunit gamma
|
decreases expression
|
EXP
|
Thiourea results in decreased expression of SCNN1G mRNA
|
CTD |
PMID:15248066 |
|
NCBI chr 1:185,736,225...185,770,099
Ensembl chr 1:185,736,191...185,770,097
|
|
G
|
Slc14a1
|
solute carrier family 14 member 1 (Kidd blood group)
|
multiple interactions
|
ISO
|
Thiourea inhibits the reaction [SLC14A1 protein affects the transport of Urea]
|
CTD |
PMID:17506977 |
|
NCBI chr18:73,840,568...73,883,925
Ensembl chr18:73,840,569...73,870,489
|
|
G
|
Slc14a2
|
solute carrier family 14 member 2
|
multiple interactions
|
EXP
|
Thiourea analog inhibits the reaction [SLC14A2 protein results in increased transport of Urea]
|
CTD |
PMID:11181411 |
|
Ensembl chr18:73,887,575...73,953,570
|
|
G
|
Spp1
|
secreted phosphoprotein 1
|
multiple interactions
|
ISO
|
Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]]
|
CTD |
PMID:10868913 |
|
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
|
|
G
|
Tp53
|
tumor protein p53
|
multiple interactions
|
ISO
|
Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein]
|
CTD |
PMID:29803612 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
|
|
|
G
|
Ca1
|
carbonic anhydrase 1
|
decreases activity
|
ISO
|
Phenylthiourea analog results in decreased activity of CA1 protein
|
CTD |
PMID:30291660 |
|
NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454
|
|
G
|
Car2
|
carbonic anhydrase 2
|
decreases activity
|
ISO
|
Phenylthiourea analog results in decreased activity of CA2 protein
|
CTD |
PMID:30291660 |
|
NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064
|
|
G
|
Casp9
|
caspase 9
|
increases expression
|
ISO
|
Phenylthiourea results in increased expression of CASP9 protein
|
CTD |
PMID:16447258 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
G
|
Fmo3
|
flavin containing dimethylaniline monoxygenase 3
|
increases response to substance
|
ISO
|
FMO3 protein results in increased susceptibility to Phenylthiourea
|
CTD |
PMID:12093470 |
|
NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256
|
|
G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
decreases expression
|
ISO
|
Phenylthiourea results in decreased expression of FOS protein
|
CTD |
PMID:18003792 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
increases phosphorylation
|
ISO
|
Phenylthiourea results in increased phosphorylation of MAPK1 protein
|
CTD |
PMID:26051519 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
increases phosphorylation
|
ISO
|
Phenylthiourea results in increased phosphorylation of MAPK3 protein
|
CTD |
PMID:26051519 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mitf
|
melanocyte inducing transcription factor
|
increases expression
|
ISO
|
Phenylthiourea results in increased expression of MITF protein
|
CTD |
PMID:26051519 |
|
NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:131,965,714...132,177,790
|
|
G
|
Ppara
|
peroxisome proliferator activated receptor alpha
|
increases expression
|
ISO
|
Phenylthiourea results in increased expression of PPARA protein
|
CTD |
PMID:16447258 |
|
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
increases expression
|
ISO
|
Phenylthiourea results in increased expression of RELA protein
|
CTD |
PMID:16447258 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
|
|
G
|
Tas2r138
|
taste receptor, type 2, member 138
|
affects response to substance multiple interactions increases activity affects activity
|
ISO
|
TAS2R38 gene polymorphism affects the susceptibility to Phenylthiourea 4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]; Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein] Phenylthiourea affects the activity of TAS2R38
|
CTD |
PMID:17684414 PMID:21629661 PMID:22384968 |
|
NCBI chr 4:70,395,042...70,396,037
|
|