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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:elemental bromine
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Accession:CHEBI:36894 term browser browse the term


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3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases activity EXP thiazolyl blue results in decreased activity of ABCB1 protein CTD PMID:15451006 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ACO2 aconitase 2 multiple interactions ISO [Calcium results in increased activity of ACO2 protein] which results in increased reduction of thiazolyl blue; [Potassium deficiency results in decreased activity of ACO2 protein] which results in decreased reduction of thiazolyl blue CTD PMID:12548706 NCBI chr22:41,469,117...41,528,974
Ensembl chr22:41,447,830...41,529,273 		JBrowse link
G CASP3 caspase 3 increases activity EXP thiazolyl blue results in increased activity of CASP3 protein CTD PMID:22401948 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 increases activity EXP thiazolyl blue results in increased activity of CASP8 protein CTD PMID:22401948 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G NQO2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 increases reduction
multiple interactions		 EXP NQO2 protein results in increased reduction of thiazolyl blue
resveratrol inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]		 CTD PMID:29281794 NCBI chr 6:2,999,894...3,019,755
Ensembl chr 6:2,987,987...3,019,755 		JBrowse link
butylscopolamine bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Butylscopolammonium Bromide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
dibromine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO Bromine results in decreased activity of and results in increased metabolism of ATP2A2 protein CTD PMID:32979061 NCBI chr12:110,280,616...110,351,093
Ensembl chr12:110,280,756...110,351,093 		JBrowse link
G CFTR CF transmembrane conductance regulator decreases activity EXP Bromine results in decreased activity of CFTR protein CTD PMID:15286085 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971 		JBrowse link
G CYBB cytochrome b-245 beta chain increases expression ISO Bromine results in increased expression of CYBB protein CTD PMID:32979061 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461 		JBrowse link
G NPPB natriuretic peptide B increases cleavage ISO Bromine results in increased cleavage of NPPB protein CTD PMID:32979061 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945 		JBrowse link
G PLN phospholamban decreases phosphorylation ISO Bromine results in decreased phosphorylation of PLN protein CTD PMID:32979061 NCBI chr 6:118,548,296...118,561,716
Ensembl chr 6:118,548,296...118,561,716 		JBrowse link
G PPEF1 protein phosphatase with EF-hand domain 1 increases expression ISO Bromine results in increased expression of PPEF1 protein CTD PMID:32979061 NCBI chr  X:18,675,067...18,827,917
Ensembl chr  X:18,675,909...18,827,921 		JBrowse link
G TNNI3 troponin I3, cardiac type increases expression ISO Bromine results in increased expression of TNNI3 protein CTD PMID:32979061 NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773 		JBrowse link
NAN 190 hydrobromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR1A 5-hydroxytryptamine receptor 1A multiple interactions ISO
EXP		 [1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin
[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Methamphetamine		 CTD PMID:15213358 PMID:15482641 PMID:16528294 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507 		JBrowse link
sodium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC5A5 solute carrier family 5 member 5 multiple interactions EXP sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m] CTD PMID:12488351 NCBI chr19:17,871,945...17,895,174
Ensembl chr19:17,871,945...17,895,174 		JBrowse link
tiotropium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRM1 cholinergic receptor muscarinic 1 affects binding EXP Tiotropium Bromide binds to CHRM1 protein CTD PMID:21870878 NCBI chr11:62,908,679...62,921,878
Ensembl chr11:62,908,679...62,921,807 		JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 affects binding EXP Tiotropium Bromide binds to CHRM2 protein CTD PMID:21870878 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255 		JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 affects binding EXP Tiotropium Bromide binds to CHRM3 protein CTD PMID:21870878 NCBI chr 1:239,386,568...239,915,450
Ensembl chr 1:239,386,565...239,915,452 		JBrowse link
G CHRM4 cholinergic receptor muscarinic 4 affects binding EXP Tiotropium Bromide binds to CHRM4 protein CTD PMID:21870878 NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,383,789...46,391,776 		JBrowse link
G CHRM5 cholinergic receptor muscarinic 5 affects binding EXP Tiotropium Bromide binds to CHRM5 protein CTD PMID:21870878 NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458 		JBrowse link
G EDN1 endothelin 1 multiple interactions EXP Tiotropium Bromide inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA] CTD PMID:22796455 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G PON1 paraoxonase 1 decreases activity EXP Tiotropium Bromide results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532 		JBrowse link
G TNF tumor necrosis factor decreases secretion EXP Tiotropium Bromide results in decreased secretion of TNF protein CTD PMID:21352583 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
tiquizium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP thiaton results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11855677 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:11855677 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
vecuronium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein] CTD PMID:30036686 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein] CTD PMID:30036686 NCBI chr21:42,199,689...42,297,244
Ensembl chr21:42,199,689...42,297,244 		JBrowse link
G CHRM1 cholinergic receptor muscarinic 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein] CTD PMID:9846649 NCBI chr11:62,908,679...62,921,878
Ensembl chr11:62,908,679...62,921,807 		JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions EXP Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:9846649 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255 		JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 multiple interactions EXP Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein] CTD PMID:9846649 NCBI chr 1:239,386,568...239,915,450
Ensembl chr 1:239,386,565...239,915,452 		JBrowse link
G CHRM4 cholinergic receptor muscarinic 4 multiple interactions EXP Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] CTD PMID:9846649 NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,383,789...46,391,776 		JBrowse link
G CHRM5 cholinergic receptor muscarinic 5 multiple interactions EXP Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] CTD PMID:9846649 NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458 		JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] CTD PMID:16931985 NCBI chr15:78,593,052...78,620,996
Ensembl chr15:78,593,052...78,621,295 		JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 PMID:16931985 NCBI chr20:63,343,223...63,361,349
Ensembl chr20:63,343,223...63,378,401 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:16931985 NCBI chr15:32,030,483...32,173,018
Ensembl chr15:31,923,438...32,173,018 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 PMID:16931985 NCBI chr 1:154,567,778...154,580,013
Ensembl chr 1:154,567,778...154,580,013 		JBrowse link
G CHRNB4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] CTD PMID:16931985 NCBI chr15:78,624,111...78,661,641
Ensembl chr15:78,624,111...78,727,754 		JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein] CTD PMID:31846720 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein] CTD PMID:30959089 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G EGR1 early growth response 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein] CTD PMID:29486207 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G ELK1 ETS transcription factor ELK1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein] CTD PMID:29486207 NCBI chr  X:47,635,520...47,650,604
Ensembl chr  X:47,635,521...47,650,604 		JBrowse link
G HDAC4 histone deacetylase 4 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein] CTD PMID:31846720 NCBI chr 2:239,048,168...239,401,649
Ensembl chr 2:239,048,168...239,401,654 		JBrowse link
G HEXB hexosaminidase subunit beta increases secretion EXP Vecuronium Bromide results in increased secretion of HEXB protein CTD PMID:19758318 NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647 		JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 increases expression
multiple interactions		 EXP Vecuronium Bromide results in increased expression of HSD11B2 mRNA; Vecuronium Bromide results in increased expression of HSD11B2 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]		 CTD PMID:29486207 NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] CTD PMID:29486207 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] CTD PMID:29486207 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein] CTD PMID:30036686 NCBI chr19:50,376,457...50,383,388
Ensembl chr19:50,329,653...50,383,388 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein] CTD PMID:30036686 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033 		JBrowse link
G SCARB1 scavenger receptor class B member 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein] CTD PMID:30036686 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668 		JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein] CTD PMID:31846720 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 25989
    chemical entity 25968
      molecular entity 25946
        elemental molecular entity 18639
          elemental halogen 9345
            elemental bromine 46
              diatomic bromine + 7
              monoatomic bromine + 39
paths to the root