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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:6-oxo steroid
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Accession:CHEBI:36883 term browser browse the term
Synonyms:related_synonym: 6-oxo steroids


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20-hydroxyecdysone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] CTD PMID:26048653 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Casp3 caspase 3 increases activity ISO Ecdysterone results in increased activity of CASP3 protein CTD PMID:29126784 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] CTD PMID:26048653 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:26048653 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hspa5 heat shock protein 5 increases expression
decreases expression
ISO Ecdysterone results in increased expression of HSPA5 mRNA
Ecdysterone results in decreased expression of HSPA5 protein
CTD PMID:29126784 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases response to substance
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone
CTD PMID:26048653 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
6-oxocampestanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO 6-oxocampestanol results in decreased expression of BCL2 protein CTD PMID:32001316 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 affects expression ISO 6-oxocampestanol affects the expression of BCL2L1 protein CTD PMID:32001316 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bid BH3 interacting domain death agonist affects expression ISO 6-oxocampestanol affects the expression of BID protein CTD PMID:32001316 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO 6-oxocampestanol results in decreased expression of CCNB1 protein CTD PMID:32001316 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO 6-oxocampestanol results in increased expression of CDKN1A protein CTD PMID:32001316 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Esr1 estrogen receptor 1 (alpha) increases expression ISO 6-oxocampestanol results in increased expression of ESR1 protein CTD PMID:32001316 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) affects localization ISO 6-oxocampestanol affects the localization of ESR2 protein CTD PMID:32001316 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Pgr progesterone receptor affects localization ISO 6-oxocampestanol affects the localization of PGR protein CTD PMID:32001316 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO 6-oxocampestanol results in increased expression of and results in increased phosphorylation of RB1 protein CTD PMID:32001316 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO 6-oxocampestanol results in increased expression of TP53 protein CTD PMID:32001316 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
ponasterone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 decreases activity
multiple interactions
ISO ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]
CTD PMID:16396944 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Fhit fragile histidine triad gene affects expression ISO ponasterone A affects the expression of FHIT protein CTD PMID:17019711 NCBI chr14:9,550,092...11,162,061
Ensembl chr14:9,550,092...11,162,035
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein] CTD PMID:16396944 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO ponasterone A results in increased expression of UGT1A3 protein CTD PMID:17058234 NCBI chr 1:88,200,611...88,220,002
Ensembl chr 1:88,200,601...88,218,997
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21727
    chemical entity 21725
      group 21602
        inorganic group 20482
          oxo group 19864
            organic oxo compound 19864
              carbonyl compound 19864
                ketone 17714
                  oxo steroid 9835
                    6-oxo steroid 19
                      (22E,24R)-3beta,5alpha,9alpha-trihydroxyergosta-7,22-dien-6-one 0
                      (22E,24R)-3beta,5alpha-dihydroxyergosta-7,22-dien-6-one 0
                      (22E,24R)-ergosta-7,22-diene-3,6-dione 0
                      2,22,25-trideoxyecdysone 0
                      2-deoxyecdysone 0
                      24-epi-cathasterone-22-O-sulfate 0
                      25-deoxyecdysone 0
                      26-hydroxycastasterone 0
                      6-ketoestriol 0
                      6-oxocampestanol 10
                      FR171456 0
                      ajugalactone 0
                      castasterone + 0
                      castasterone 23-O-alpha-D-glucoside 0
                      cathasterone + 0
                      cyasterone 0
                      ecdysone + 6
                      ganodesterone 0
                      inokosterone 0
                      makisterone B 0
                      podecdysone B 0
                      polypodine B 0
                      ponasterone A 4
                      poststerone 0
                      shidasterone 0
                      teasterone + 0
                      typhasterol + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21727
    subatomic particle 21713
      composite particle 21713
        hadron 21713
          baryon 21713
            nucleon 21713
              atomic nucleus 21713
                atom 21713
                  main group element atom 21629
                    p-block element atom 21629
                      carbon group element atom 21434
                        carbon atom 21334
                          organic molecular entity 21334
                            organic group 19894
                              organic divalent group 19881
                                organodiyl group 19881
                                  carbonyl group 19864
                                    carbonyl compound 19864
                                      ketone 17714
                                        oxo steroid 9835
                                          6-oxo steroid 19
                                            (22E,24R)-3beta,5alpha,9alpha-trihydroxyergosta-7,22-dien-6-one 0
                                            (22E,24R)-3beta,5alpha-dihydroxyergosta-7,22-dien-6-one 0
                                            (22E,24R)-ergosta-7,22-diene-3,6-dione 0
                                            2,22,25-trideoxyecdysone 0
                                            2-deoxyecdysone 0
                                            24-epi-cathasterone-22-O-sulfate 0
                                            25-deoxyecdysone 0
                                            26-hydroxycastasterone 0
                                            6-ketoestriol 0
                                            6-oxocampestanol 10
                                            FR171456 0
                                            ajugalactone 0
                                            castasterone + 0
                                            castasterone 23-O-alpha-D-glucoside 0
                                            cathasterone + 0
                                            cyasterone 0
                                            ecdysone + 6
                                            ganodesterone 0
                                            inokosterone 0
                                            makisterone B 0
                                            podecdysone B 0
                                            polypodine B 0
                                            ponasterone A 4
                                            poststerone 0
                                            shidasterone 0
                                            teasterone + 0
                                            typhasterol + 0
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