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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:6-oxo steroid
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Accession:CHEBI:36883 term browser browse the term
Synonyms:related_synonym: 6-oxo steroids


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20-hydroxyecdysone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] CTD PMID:26048653 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G CASP3 caspase 3 increases activity EXP Ecdysterone results in increased activity of CASP3 protein CTD PMID:29126784 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] CTD PMID:26048653 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:26048653 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression
decreases expression
EXP Ecdysterone results in increased expression of HSPA5 mRNA
Ecdysterone results in decreased expression of HSPA5 protein
CTD PMID:29126784 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions
increases response to substance
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone
CTD PMID:26048653 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
6-oxocampestanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator decreases expression EXP 6-oxocampestanol results in decreased expression of BCL2 protein CTD PMID:32001316 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 affects expression EXP 6-oxocampestanol affects the expression of BCL2L1 protein CTD PMID:32001316 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BID BH3 interacting domain death agonist affects expression EXP 6-oxocampestanol affects the expression of BID protein CTD PMID:32001316 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G CCNB1 cyclin B1 decreases expression EXP 6-oxocampestanol results in decreased expression of CCNB1 protein CTD PMID:32001316 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP 6-oxocampestanol results in increased expression of CDKN1A protein CTD PMID:32001316 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G ESR1 estrogen receptor 1 increases expression EXP 6-oxocampestanol results in increased expression of ESR1 protein CTD PMID:32001316 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 affects localization EXP 6-oxocampestanol affects the localization of ESR2 protein CTD PMID:32001316 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G PGR progesterone receptor affects localization EXP 6-oxocampestanol affects the localization of PGR protein CTD PMID:32001316 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G RB1 RB transcriptional corepressor 1 multiple interactions EXP 6-oxocampestanol results in increased expression of and results in increased phosphorylation of RB1 protein CTD PMID:32001316 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G TP53 tumor protein p53 increases expression EXP 6-oxocampestanol results in increased expression of TP53 protein CTD PMID:32001316 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
ponasterone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases activity
multiple interactions
ISO ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]
CTD PMID:16396944 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase affects expression EXP ponasterone A affects the expression of FHIT protein CTD PMID:17019711 NCBI chr 3:59,747,277...61,251,452
Ensembl chr 3:59,747,277...61,251,459
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein] CTD PMID:16396944 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases expression EXP ponasterone A results in increased expression of UGT1A3 protein CTD PMID:17058234 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,108...233,773,299
Ensembl chr 2:233,729,108...233,773,299
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24513
    chemical entity 24481
      group 24374
        inorganic group 23218
          oxo group 22371
            organic oxo compound 22371
              carbonyl compound 22371
                ketone 19055
                  oxo steroid 10165
                    6-oxo steroid 19
                      (22E,24R)-3beta,5alpha,9alpha-trihydroxyergosta-7,22-dien-6-one 0
                      (22E,24R)-3beta,5alpha-dihydroxyergosta-7,22-dien-6-one 0
                      (22E,24R)-ergosta-7,22-diene-3,6-dione 0
                      2,22,25-trideoxyecdysone 0
                      2-deoxyecdysone 0
                      24-epi-cathasterone-22-O-sulfate 0
                      25-deoxyecdysone 0
                      26-hydroxycastasterone 0
                      6-ketoestriol 0
                      6-oxocampestanol 10
                      FR171456 0
                      ajugalactone 0
                      castasterone + 0
                      castasterone 23-O-alpha-D-glucoside 0
                      cathasterone + 0
                      cyasterone 0
                      ecdysone + 6
                      ganodesterone 0
                      inokosterone 0
                      makisterone B 0
                      podecdysone B 0
                      polypodine B 0
                      ponasterone A 4
                      poststerone 0
                      shidasterone 0
                      teasterone + 0
                      typhasterol + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24513
    subatomic particle 24471
      composite particle 24471
        hadron 24471
          baryon 24471
            nucleon 24471
              atomic nucleus 24471
                atom 24471
                  main group element atom 24329
                    p-block element atom 24329
                      carbon group element atom 24114
                        carbon atom 24076
                          organic molecular entity 24076
                            organic group 22409
                              organic divalent group 22386
                                organodiyl group 22386
                                  carbonyl group 22371
                                    carbonyl compound 22371
                                      ketone 19055
                                        oxo steroid 10165
                                          6-oxo steroid 19
                                            (22E,24R)-3beta,5alpha,9alpha-trihydroxyergosta-7,22-dien-6-one 0
                                            (22E,24R)-3beta,5alpha-dihydroxyergosta-7,22-dien-6-one 0
                                            (22E,24R)-ergosta-7,22-diene-3,6-dione 0
                                            2,22,25-trideoxyecdysone 0
                                            2-deoxyecdysone 0
                                            24-epi-cathasterone-22-O-sulfate 0
                                            25-deoxyecdysone 0
                                            26-hydroxycastasterone 0
                                            6-ketoestriol 0
                                            6-oxocampestanol 10
                                            FR171456 0
                                            ajugalactone 0
                                            castasterone + 0
                                            castasterone 23-O-alpha-D-glucoside 0
                                            cathasterone + 0
                                            cyasterone 0
                                            ecdysone + 6
                                            ganodesterone 0
                                            inokosterone 0
                                            makisterone B 0
                                            podecdysone B 0
                                            polypodine B 0
                                            ponasterone A 4
                                            poststerone 0
                                            shidasterone 0
                                            teasterone + 0
                                            typhasterol + 0
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