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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:6-oxo steroid
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Accession:CHEBI:36883 term browser browse the term
Synonyms:related_synonym: 6-oxo steroids


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20-hydroxyecdysone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] CTD PMID:26048653 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp3 caspase 3 increases activity ISO Ecdysterone results in increased activity of CASP3 protein CTD PMID:29126784 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] CTD PMID:26048653 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:26048653 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
increases expression
ISO Ecdysterone results in decreased expression of HSPA5 protein
Ecdysterone results in increased expression of HSPA5 mRNA
CTD PMID:29126784 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases response to substance
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone
CTD PMID:26048653 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
6-oxocampestanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 6-oxocampestanol results in decreased expression of BCL2 protein CTD PMID:32001316 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 affects expression ISO 6-oxocampestanol affects the expression of BCL2L1 protein CTD PMID:32001316 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist affects expression ISO 6-oxocampestanol affects the expression of BID protein CTD PMID:32001316 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO 6-oxocampestanol results in decreased expression of CCNB1 protein CTD PMID:32001316 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 6-oxocampestanol results in increased expression of CDKN1A protein CTD PMID:32001316 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO 6-oxocampestanol results in increased expression of ESR1 protein CTD PMID:32001316 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 affects localization ISO 6-oxocampestanol affects the localization of ESR2 protein CTD PMID:32001316 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Pgr progesterone receptor affects localization ISO 6-oxocampestanol affects the localization of PGR protein CTD PMID:32001316 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO 6-oxocampestanol results in increased expression of and results in increased phosphorylation of RB1 protein CTD PMID:32001316 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Tp53 tumor protein p53 increases expression ISO 6-oxocampestanol results in increased expression of TP53 protein CTD PMID:32001316 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
ponasterone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 decreases activity
multiple interactions
EXP ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]
CTD PMID:16396944 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase affects expression ISO ponasterone A affects the expression of FHIT protein CTD PMID:17019711 NCBI chr15:15,697,292...16,862,873 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein] CTD PMID:16396944 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO ponasterone A results in increased expression of UGT1A3 protein CTD PMID:17058234 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      group 19696
        inorganic group 19146
          oxo group 18389
            organic oxo compound 18389
              carbonyl compound 18389
                ketone 16140
                  oxo steroid 9275
                    6-oxo steroid 19
                      (22E,24R)-3beta,5alpha,9alpha-trihydroxyergosta-7,22-dien-6-one 0
                      (22E,24R)-3beta,5alpha-dihydroxyergosta-7,22-dien-6-one 0
                      (22E,24R)-ergosta-7,22-diene-3,6-dione 0
                      2,22,25-trideoxyecdysone 0
                      2-deoxyecdysone 0
                      24-epi-cathasterone-22-O-sulfate 0
                      25-deoxyecdysone 0
                      26-hydroxycastasterone 0
                      6-ketoestriol 0
                      6-oxocampestanol 10
                      FR171456 0
                      ajugalactone 0
                      castasterone + 0
                      castasterone 23-O-alpha-D-glucoside 0
                      cathasterone + 0
                      cyasterone 0
                      ecdysone + 6
                      ganodesterone 0
                      inokosterone 0
                      makisterone B 0
                      podecdysone B 0
                      polypodine B 0
                      ponasterone A 4
                      poststerone 0
                      shidasterone 0
                      teasterone + 0
                      typhasterol + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        oxo steroid 9275
                                          6-oxo steroid 19
                                            (22E,24R)-3beta,5alpha,9alpha-trihydroxyergosta-7,22-dien-6-one 0
                                            (22E,24R)-3beta,5alpha-dihydroxyergosta-7,22-dien-6-one 0
                                            (22E,24R)-ergosta-7,22-diene-3,6-dione 0
                                            2,22,25-trideoxyecdysone 0
                                            2-deoxyecdysone 0
                                            24-epi-cathasterone-22-O-sulfate 0
                                            25-deoxyecdysone 0
                                            26-hydroxycastasterone 0
                                            6-ketoestriol 0
                                            6-oxocampestanol 10
                                            FR171456 0
                                            ajugalactone 0
                                            castasterone + 0
                                            castasterone 23-O-alpha-D-glucoside 0
                                            cathasterone + 0
                                            cyasterone 0
                                            ecdysone + 6
                                            ganodesterone 0
                                            inokosterone 0
                                            makisterone B 0
                                            podecdysone B 0
                                            polypodine B 0
                                            ponasterone A 4
                                            poststerone 0
                                            shidasterone 0
                                            teasterone + 0
                                            typhasterol + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.