6-oxo steroid - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	6-oxo steroid	go back to main search page
Accession:	CHEBI:36883	browse the term
Synonyms:	related_synonym:	6-oxo steroids

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Rat (27) Mouse (27) Human (27) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (27)

20-hydroxyecdysone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BCL2 associated X, apoptosis regulator

increases expression

Ecdysterone results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

affects expression

Ecdysterone affects the expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

increases activity
increases cleavage

Ecdysterone results in increased activity of CASP3 protein
Ecdysterone results in increased cleavage of CASP3 protein

PMID:29126784 PMID:33878320

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

glycogen synthase kinase 3 beta

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

heme oxygenase 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 5

decreases expression
increases expression

Ecdysterone results in decreased expression of HSPA5 protein
Ecdysterone results in increased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

mechanistic target of rapamycin kinase

affects expression

Ecdysterone affects the expression of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases response to substance

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

poly (ADP-ribose) polymerase 1

increases cleavage

Ecdysterone results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

sequestosome 1

affects expression

Ecdysterone affects the expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

6-oxocampestanol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2, apoptosis regulator

decreases expression

6-oxocampestanol results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

affects expression

6-oxocampestanol affects the expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

BH3 interacting domain death agonist

affects expression

6-oxocampestanol affects the expression of BID protein

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

cyclin B1

decreases expression

6-oxocampestanol results in decreased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin-dependent kinase inhibitor 1A

increases expression

6-oxocampestanol results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

estrogen receptor 1

increases expression

6-oxocampestanol results in increased expression of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

affects localization

6-oxocampestanol affects the localization of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

progesterone receptor

affects localization

6-oxocampestanol affects the localization of PGR protein

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

RB transcriptional corepressor 1

multiple interactions

6-oxocampestanol results in increased expression of and results in increased phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

tumor protein p53

increases expression

6-oxocampestanol results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

ponasterone A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

decreases activity
multiple interactions

ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

dynamin 1-like

multiple interactions

[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of DNM1L protein

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

fragile histidine triad diadenosine triphosphatase

affects expression

ponasterone A affects the expression of FHIT protein

NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340

G

fission, mitochondrial 1

multiple interactions

[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein]

NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377

G

mitofusin 2

increases expression

[ponasterone A results in increased expression of PINK1 protein] which results in increased expression of MFN2 protein

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

PTEN induced kinase 1

multiple interactions
increases expression

[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of DNM1L protein; [ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein]
[ponasterone A results in increased expression of PINK1 protein] which results in increased expression of MFN2 protein; ponasterone A results in increased expression of PINK1 protein

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases expression

ponasterone A results in increased expression of UGT1A3 protein

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19853
chemical entity	19851
group	19809
inorganic group	19390
oxo group	18893
organic oxo compound	18893
carbonyl compound	18893
ketone	17191
oxo steroid	10545
6-oxo steroid	27
(22E,24R)-3beta,5alpha,9alpha-trihydroxyergosta-7,22-dien-6-one	0
(22E,24R)-3beta,5alpha-dihydroxyergosta-7,22-dien-6-one	0
(22E,24R)-ergosta-7,22-diene-3,6-dione	0
2,22,25-trideoxyecdysone	0
2-deoxyecdysone	0
24-epi-cathasterone-22-O-sulfate	0
25-deoxyecdysone	0
26-hydroxycastasterone	0
28-norcastasterone	0
28-norteasterone	0
28-nortyphasterol	0
3-dehydroteasterone	0
6-dehydro-28-norteasterone	0
6-ketoestriol	0
6-oxocampestanol	10
FR171456	0
ajugalactone	0
asterasterol B	0
asterasterol C	0
castasterone +	0
castasterone 23-O-alpha-D-glucoside	0
cathasterone +	0
cyasterone	0
ecdysone +	11
ganodesterone	0
inokosterone	0
makisterone B	0
podecdysone B	0
polypodine B	0
ponasterone A	8
poststerone	0
shidasterone	0
teasterone +	0
typhasterol +	0
Path 2
Term	Annotations
CHEBI ontology	19853
subatomic particle	19851
composite particle	19851
hadron	19851
baryon	19851
nucleon	19851
atomic nucleus	19851
atom	19851
main group element atom	19797
p-block element atom	19797
carbon group element atom	19738
carbon atom	19734
organic molecular entity	19734
heteroorganic entity	19492
organochalcogen compound	19254
organooxygen compound	19170
carbonyl compound	18893
ketone	17191
oxo steroid	10545
6-oxo steroid	27
(22E,24R)-3beta,5alpha,9alpha-trihydroxyergosta-7,22-dien-6-one	0
(22E,24R)-3beta,5alpha-dihydroxyergosta-7,22-dien-6-one	0
(22E,24R)-ergosta-7,22-diene-3,6-dione	0
2,22,25-trideoxyecdysone	0
2-deoxyecdysone	0
24-epi-cathasterone-22-O-sulfate	0
25-deoxyecdysone	0
26-hydroxycastasterone	0
28-norcastasterone	0
28-norteasterone	0
28-nortyphasterol	0
3-dehydroteasterone	0
6-dehydro-28-norteasterone	0
6-ketoestriol	0
6-oxocampestanol	10
FR171456	0
ajugalactone	0
asterasterol B	0
asterasterol C	0
castasterone +	0
castasterone 23-O-alpha-D-glucoside	0
cathasterone +	0
cyasterone	0
ecdysone +	11
ganodesterone	0
inokosterone	0
makisterone B	0
podecdysone B	0
polypodine B	0
ponasterone A	8
poststerone	0
shidasterone	0
teasterone +	0
typhasterol +	0

paths to the root