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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:radical ion
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Accession:CHEBI:36875 term browser browse the term
Definition:A radical that carries an electric charge.
Synonyms:related_synonym: radical ions


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superoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 multiple interactions EXP ABCC1 protein affects the reaction [AGT protein results in increased abundance of Superoxides] CTD PMID:17272743 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Aco1 aconitase 1 decreases activity
multiple interactions
EXP Superoxides results in decreased activity of ACO1 protein
[SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein
CTD PMID:28542246 NCBI chr 4:40,143,265...40,199,009
Ensembl chr 4:40,143,081...40,198,338
JBrowse link
G Aco2 aconitase 2, mitochondrial multiple interactions
decreases activity
ISO [[[Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron] which co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Hydroxyl Radical; [Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron CTD PMID:16162655 NCBI chr15:81,872,463...81,915,137
Ensembl chr15:81,872,309...81,915,133
JBrowse link
G Ada adenosine deaminase multiple interactions ISO ADA protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides] CTD PMID:10947063 NCBI chr 2:163,726,571...163,750,239
Ensembl chr 2:163,726,584...163,750,239
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions
increases abundance
EXP
ISO
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; ABCC1 protein affects the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; ATOX1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; NOS3 protein affects the reaction [AGT protein results in increased abundance of Superoxides]; Propranolol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides]; SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]
SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]
AGT protein modified form results in increased abundance of Superoxides; AGT protein results in increased abundance of Superoxides
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]
CTD PMID:12606818 PMID:16531806 PMID:16864745 PMID:17272743 PMID:17391658 More... NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] CTD PMID:23824088 NCBI chr13:30,336,356...30,382,867
Ensembl chr13:30,336,441...30,382,867
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 multiple interactions ISO [AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone] which results in increased abundance of Superoxides; [AKR1C3 protein results in increased reduction of and affects the activity of benzo(a)pyrene-3,6-quinone] which results in increased chemical synthesis of Superoxides CTD PMID:19442656 PMID:21910479 NCBI chr13:4,132,615...4,150,646
Ensembl chr13:4,132,615...4,150,654
JBrowse link
G Akr7a5 aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase) multiple interactions ISO [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of 4-hydroxyequilenin-o-quinone] which results in increased chemical synthesis of Superoxides; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Superoxides CTD PMID:21910479 NCBI chr 4:139,310,720...139,318,786
Ensembl chr 4:139,310,744...139,318,426
JBrowse link
G Alb albumin increases chemical synthesis
multiple interactions
ISO ALB protein modified form results in increased chemical synthesis of Superoxides
Etomidate promotes the reaction [ALB protein modified form results in increased chemical synthesis of Superoxides]
CTD PMID:25421967 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Aldh5a1 aldhehyde dehydrogenase family 5, subfamily A1 multiple interactions EXP [ALDH5A1 gene mutant form results in increased susceptibility to 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one] which results in increased abundance of Superoxides; [ALDH5A1 gene mutant form results in increased susceptibility to NCS 382] which results in increased abundance of Superoxides CTD PMID:29031482 NCBI chr13:24,907,579...24,937,661
Ensembl chr13:24,907,579...24,937,661
JBrowse link
G Apoe apolipoprotein E increases chemical synthesis
increases abundance
multiple interactions
EXP APOE gene mutant form results in increased chemical synthesis of Superoxides
APOE gene mutant form results in increased abundance of Superoxides
imisopasem manganese inhibits the reaction [APOE gene mutant form results in increased chemical synthesis of Superoxides]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [APOE gene mutant form results in increased abundance of Superoxides]
CTD PMID:11397713 PMID:12871831 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions
increases chemical synthesis
ISO 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; GW 501516 inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; resveratrol inhibits the reaction [APP protein results in increased abundance of Superoxides] CTD PMID:16212921 PMID:22886847 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Ar androgen receptor multiple interactions ISO Superoxides promotes the reaction [methylselenic acid results in decreased expression of AR protein] CTD PMID:16928829 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Arf6 ADP-ribosylation factor 6 multiple interactions ISO 1-Butanol inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 1-Butanol inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]; ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides] CTD PMID:10931844 NCBI chr12:69,372,150...69,375,980
Ensembl chr12:69,372,150...69,373,783
JBrowse link
G Arrb2 arrestin, beta 2 affects abundance EXP ARRB2 protein affects the abundance of Superoxides CTD PMID:16210646 NCBI chr11:70,432,485...70,440,828
Ensembl chr11:70,432,635...70,440,828
JBrowse link
G Atox1 antioxidant 1 copper chaperone multiple interactions EXP ATOX1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides] CTD PMID:22753205 NCBI chr11:55,446,637...55,461,208
Ensembl chr11:55,446,641...55,461,239
JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide increases abundance
multiple interactions
EXP ATP7A mutant form results in increased abundance of Superoxides
[ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; ATP7A gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; ATP7A protein inhibits the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]
CTD PMID:18768397 PMID:23884884 NCBI chr  X:106,027,224...106,128,161
Ensembl chr  X:106,027,276...106,124,926
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; CAT protein inhibits the reaction [Superoxides results in increased secretion of TGFB1 protein] CTD PMID:19268487 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cbs cystathionine beta-synthase affects abundance
multiple interactions
EXP CBS protein affects the abundance of Superoxides
SMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides]
CTD PMID:23024785 NCBI chr17:31,612,623...31,637,233
Ensembl chr17:31,608,894...31,637,238
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions
increases expression
ISO
EXP
Superoxides affects the reaction [Fructose results in increased secretion of CCL2 protein]
Superoxides results in increased expression of CCL2 mRNA
1,3-dimethylthiourea inhibits the reaction [Superoxides results in increased expression of CCL2 mRNA]
CTD PMID:8856246 PMID:19158351 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Cd38 CD38 antigen affects localization
multiple interactions
EXP Superoxides affects the localization of CD38 protein
tempol inhibits the reaction [Superoxides affects the localization of CD38 protein]
CTD PMID:23940720 NCBI chr 5:43,868,809...43,912,374
Ensembl chr 5:43,868,553...43,912,375
JBrowse link
G Crp C-reactive protein, pentraxin-related multiple interactions ISO CRP protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] CTD PMID:9767445 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Cyba cytochrome b-245, alpha polypeptide multiple interactions
increases abundance
ISO CYBA protein promotes the reaction [arsenite results in increased abundance of Superoxides]
CYBA protein results in increased abundance of Superoxides
CTD PMID:10720412 PMID:14871555 PMID:20523355 NCBI chr 8:122,424,771...122,432,940
Ensembl chr 8:122,424,776...122,432,930
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions EXP
ISO
CYBB mutant form inhibits the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein affects the reaction [Folic Acid deficiency results in increased chemical synthesis of Superoxides]; CYBB protein affects the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein promotes the reaction [[Doxorubicin co-treated with NADP] results in increased abundance of Superoxides]
IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides]
CTD PMID:16354686 PMID:17275678 PMID:20116427 PMID:21647593 NCBI chr  X:9,435,252...9,487,766
Ensembl chr  X:9,435,252...9,487,771
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases abundance EXP CYP1A1 protein results in increased abundance of Superoxides CTD PMID:20634294 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Dcxr dicarbonyl L-xylulose reductase multiple interactions
increases chemical synthesis
ISO [DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides; Diacetyl inhibits the reaction [[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides]
DCXR protein results in increased chemical synthesis of Superoxides
CTD PMID:28595002 NCBI chr11:120,724,546...120,727,284
Ensembl chr11:120,725,399...120,727,281
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases abundance
increases expression
multiple interactions
EXP DDIT3 protein results in increased abundance of Superoxides
Superoxides results in increased expression of DDIT3 mRNA; Superoxides results in increased expression of DDIT3 protein
[DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 protein; [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein
CTD PMID:16400006 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases abundance
ISO
EXP
[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides; Catechin inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]; NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]; Polyphenols inhibits the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]
NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]
CTD PMID:20977430 PMID:23940720 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Ednra endothelin receptor type A affects abundance ISO EDNRA protein affects the abundance of Superoxides CTD PMID:12600921 NCBI chr 8:77,663,029...77,724,452
Ensembl chr 8:77,663,031...77,724,464
JBrowse link
G Ep300 E1A binding protein p300 decreases abundance ISO EP300 protein results in decreased abundance of Superoxides CTD PMID:25440059 NCBI chr15:81,586,209...81,652,077
Ensembl chr15:81,585,351...81,652,077
JBrowse link
G Epo erythropoietin multiple interactions EXP EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides] CTD PMID:25490417 NCBI chr 5:137,483,020...137,485,816
Ensembl chr 5:137,483,020...137,533,242
JBrowse link
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 multiple interactions
increases abundance
decreases abundance
ISO 3-aminobenzamide inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; NU 1025 inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]
ERCC6 protein results in decreased abundance of Superoxides
CTD PMID:25440059 NCBI chr14:32,513,291...32,580,990
Ensembl chr14:32,513,521...32,580,990
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol binds to and results in increased activity of ESR1 protein] which results in decreased abundance of Superoxides; [ESR1 protein results in increased susceptibility to Estradiol] which results in increased abundance of Superoxides; ESR1 protein affects the reaction [Estradiol results in decreased chemical synthesis of Superoxides] CTD PMID:18354059 PMID:23000059 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions
increases abundance
ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [FMR1 5' UTR mutant form results in increased abundance of Superoxides] CTD PMID:27385396 NCBI chr  X:68,678,536...68,717,963
Ensembl chr  X:68,678,541...68,717,963
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Superoxides affects the reaction [Glucose results in increased expression of FN1 mRNA] CTD PMID:16572112 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases expression
EXP SOD2 protein inhibits the reaction [Superoxides results in increased expression of FOS mRNA] CTD PMID:9067545 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
CTD PMID:11050244 NCBI chr 6:125,161,852...125,166,467
Ensembl chr 6:125,161,715...125,166,467
JBrowse link
G Gas5 growth arrest specific 5 increases expression EXP Superoxides results in increased expression of GAS5 mRNA; Superoxides results in increased expression of GAS5 protein CTD PMID:16400006 NCBI chr 1:161,034,601...161,038,539
Ensembl chr 1:161,034,422...161,038,539
JBrowse link
G Gch1 GTP cyclohydrolase 1 affects abundance EXP GCH1 protein affects the abundance of Superoxides CTD PMID:21963838 NCBI chr14:47,153,895...47,189,413
Ensembl chr14:47,153,895...47,189,413
JBrowse link
G Hc hemolytic complement multiple interactions
increases abundance
ISO 8-(4-sulfophenyl)theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline inhibits the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides] CTD PMID:10947063 NCBI chr 2:34,983,329...35,068,506
Ensembl chr 2:34,983,331...35,061,438
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases abundance
increases abundance
EXP
ISO
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; Deferoxamine inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]
HMOX1 protein results in decreased abundance of Superoxides
[tetrathiomolybdate analog results in increased abundance of Superoxides] which results in increased reduction of HMOX1 protein
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; [cobaltous chloride results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; [stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Superoxides; [tin mesoporphyrin results in decreased activity of HMOX1 protein] which results in increased abundance of Superoxides; Deferoxamine inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]
CTD PMID:15821039 PMID:16959961 PMID:18073186 PMID:18178725 PMID:18334666 More... NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hras Harvey rat sarcoma virus oncogene increases abundance
multiple interactions
ISO HRAS protein mutant form results in increased abundance of Superoxides
[HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein
CTD PMID:11313892 NCBI chr 7:141,189,934...141,194,019
Ensembl chr 7:141,189,105...141,194,005
JBrowse link
G Hspb1 heat shock protein 1 multiple interactions
decreases abundance
EXP [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of HSPB1 protein
HSPB1 protein results in decreased abundance of Superoxides
CTD PMID:14975446 PMID:19193722 NCBI chr 5:135,887,919...135,889,563
Ensembl chr 5:135,887,919...135,889,563
JBrowse link
G Ier3 immediate early response 3 affects chemical synthesis EXP IER3 protein affects the chemical synthesis of Superoxides CTD PMID:20713914 NCBI chr17:35,821,713...35,822,911
Ensembl chr17:35,821,684...35,822,923
JBrowse link
G Igf1 insulin-like growth factor 1 decreases abundance ISO IGF1 protein results in decreased abundance of Superoxides CTD PMID:22843358 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
ISO diphenyleneiodonium inhibits the reaction [IL1B protein results in increased abundance of Superoxides]; IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides] CTD PMID:16354686 PMID:21211511 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il5 interleukin 5 multiple interactions ISO 1-Methyl-3-isobutylxanthine promotes the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]; Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]; ICI 118551 inhibits the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]] CTD PMID:16238794 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106
JBrowse link
G Itga3 integrin alpha 3 multiple interactions EXP [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 protein CTD PMID:16400006 NCBI chr11:95,044,475...95,076,844
Ensembl chr11:95,044,474...95,076,801
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) multiple interactions EXP [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein CTD PMID:16400006 NCBI chr 8:128,685,654...128,733,579
Ensembl chr 8:128,685,654...128,733,200
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression
ISO
EXP
Superoxides affects the reaction [Glucose results in increased phosphorylation of JUN protein]
Superoxides results in increased expression of JUN mRNA
SOD2 protein inhibits the reaction [Superoxides results in increased expression of JUN mRNA]
CTD PMID:9067545 PMID:16572112 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Kat2a K(lysine) acetyltransferase 2A decreases abundance ISO KAT2A protein results in decreased abundance of Superoxides CTD PMID:25440059 NCBI chr11:100,704,746...100,712,485
Ensembl chr11:100,704,746...100,712,465
JBrowse link
G Kat2b K(lysine) acetyltransferase 2B decreases abundance ISO KAT2B protein results in decreased abundance of Superoxides CTD PMID:25440059 NCBI chr17:53,566,774...53,672,721
Ensembl chr17:53,566,861...53,672,720
JBrowse link
G Kdr kinase insert domain protein receptor increases phosphorylation ISO Superoxides results in increased phosphorylation of KDR protein CTD PMID:19571580 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Lep leptin multiple interactions
increases abundance
EXP
ISO
acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]; BQ 788 inhibits the reaction [LEP protein results in increased abundance of Superoxides]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased abundance of Superoxides]
[LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides
CTD PMID:11342529 PMID:16380530 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lepr leptin receptor multiple interactions
increases abundance
EXP acetovanillone inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides]; resveratrol inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides] CTD PMID:19478208 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
ISO Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
Superoxides results in increased phosphorylation of MAPK1 protein
CTD PMID:16572112 PMID:19268487 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
ISO Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
Superoxides results in increased phosphorylation of MAPK3 protein
CTD PMID:16572112 PMID:19268487 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP Superoxides results in increased phosphorylation of MAPK8 protein CTD PMID:33290831 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation EXP Superoxides results in increased phosphorylation of MAPK9 protein CTD PMID:33290831 NCBI chr11:49,846,728...49,886,421
Ensembl chr11:49,846,751...49,886,421
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [MPO protein results in increased oxidation of hydrazine] which results in increased chemical synthesis of Superoxides CTD PMID:26867495 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Mt3 metallothionein 3 decreases response to substance ISO MT3 protein results in decreased susceptibility to Superoxides CTD PMID:12383939 NCBI chr 8:94,152,607...94,154,148
Ensembl chr 8:94,152,607...94,154,146
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO NCF1 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides] CTD PMID:17448908 NCBI chr 5:134,220,053...134,229,628
Ensembl chr 5:134,220,053...134,229,625
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO NCF2 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides] CTD PMID:17448908 NCBI chr 1:152,800,153...152,836,990
Ensembl chr 1:152,800,194...152,836,991
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP [Ozone results in increased expression of NOS2 protein] which results in increased abundance of Superoxides CTD PMID:11919077 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions
affects chemical synthesis
decreases abundance
increases abundance
ISO
EXP
7,8-dihydrobiopterin promotes the reaction [NOS3 protein results in increased abundance of Superoxides]; [Equol results in increased chemical synthesis of Superoxides] which results in increased activity of and results in increased phosphorylation of NOS3 protein; sapropterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides]; sapropterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Equol results in increased chemical synthesis of Superoxides] which results in increased phosphorylation of NOS3 protein]
NOS3 protein affects the chemical synthesis of Superoxides
NOS3 protein results in decreased abundance of Superoxides
[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]; NOS3 protein affects the reaction [AGT protein results in increased abundance of Superoxides]
[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides; Nitroglycerin promotes the reaction [[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides]; NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]
CTD PMID:10625313 PMID:17272743 PMID:18714161 PMID:19011239 PMID:19696404 More... NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions
increases abundance
ISO
EXP
[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]; NOX1 mRNA promotes the reaction [Tobacco Smoke Pollution results in increased chemical synthesis of Superoxides]
diphenyleneiodonium inhibits the reaction [NOX1 protein results in increased abundance of Superoxides]; NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]
CTD PMID:23824088 PMID:23940720 PMID:24912985 PMID:27816504 NCBI chr  X:134,086,421...134,137,711
Ensembl chr  X:134,086,421...134,221,956
JBrowse link
G Nox3 NADPH oxidase 3 multiple interactions EXP [resveratrol results in decreased expression of and results in decreased activity of NOX3 protein] which results in decreased abundance of Superoxides CTD PMID:20675566 NCBI chr17:3,635,240...3,696,261
Ensembl chr17:3,635,240...3,696,261
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO NOX4 promotes the reaction [sodium arsenite results in increased abundance of Superoxides] CTD PMID:26535918 NCBI chr 7:87,244,430...87,398,710
Ensembl chr 7:87,246,096...87,398,710
JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 multiple interactions EXP PARK7 protein affects the reaction [Paraquat results in increased abundance of Superoxides] CTD PMID:21300143 NCBI chr 4:150,897,133...150,909,921
Ensembl chr 4:150,897,133...150,914,437
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 affects abundance ISO PDHA1 protein affects the abundance of Superoxides CTD PMID:21846590 NCBI chr  X:160,122,219...160,138,430
Ensembl chr  X:160,122,209...160,138,413
JBrowse link
G Pink1 PTEN induced putative kinase 1 affects abundance EXP PINK1 protein affects the abundance of Superoxides CTD PMID:21421046 NCBI chr 4:138,313,409...138,326,296
Ensembl chr 4:138,313,409...138,326,307
JBrowse link
G Polg polymerase (DNA directed), gamma multiple interactions
increases chemical synthesis
EXP Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin inhibits the reaction [POLG protein results in increased chemical synthesis of Superoxides]; polyethylene glycol-superoxide dismutase inhibits the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides]; Rotenone promotes the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides] CTD PMID:30038268 NCBI chr 7:79,446,231...79,467,911
Ensembl chr 7:79,446,231...79,466,362
JBrowse link
G Pomc pro-opiomelanocortin-alpha increases abundance ISO POMC protein results in increased abundance of Superoxides CTD PMID:16620303 NCBI chr12:3,954,945...3,960,643
Ensembl chr12:3,954,951...3,960,642
JBrowse link
G Pon2 paraoxonase 2 increases expression EXP Superoxides results in increased expression of PON2 protein CTD PMID:15544923 NCBI chr 6:5,264,620...5,298,345
Ensembl chr 6:5,264,147...5,298,455
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO
EXP
[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; [POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides]
[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]
CTD PMID:21215309 NCBI chr 5:135,670,040...135,735,326
Ensembl chr 5:135,670,033...135,735,326
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO [Ethanol results in increased localization of and results in increased activity of PRKCA protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] CTD PMID:10651808 NCBI chr11:107,933,387...108,343,888
Ensembl chr11:107,933,387...108,343,928
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO [Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] CTD PMID:10651808 NCBI chr 7:122,289,104...122,634,402
Ensembl chr 7:122,288,751...122,634,402
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP resveratrol inhibits the reaction [Superoxides results in increased expression of PTGS2 protein] CTD PMID:10718345 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions ISO [resveratrol results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides CTD PMID:21544240 NCBI chr11:86,498,869...86,544,885
Ensembl chr11:86,498,871...86,544,805
JBrowse link
G Selenoh selenoprotein H decreases abundance ISO SELENOH protein results in decreased abundance of Superoxides CTD PMID:17389926 NCBI chr 2:84,669,215...84,670,708
Ensembl chr 2:84,669,215...84,670,770
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO [[Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein] which results in decreased secretion of SERPINE1 protein CTD PMID:11681624 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Superoxides]] CTD PMID:18424637 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Slc25a14 solute carrier family 25 (mitochondrial carrier, brain), member 14 multiple interactions ISO SLC25A14 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased abundance of Superoxides]; SLC25A14 protein inhibits the reaction [Dopamine results in increased abundance of Superoxides] CTD PMID:20600837 NCBI chr  X:48,623,418...48,662,298
Ensembl chr  X:48,623,413...48,662,294
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1, acid lysosomal multiple interactions EXP SMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides] CTD PMID:23024785 NCBI chr 7:105,554,360...105,558,389
Ensembl chr 7:105,554,360...105,558,389
JBrowse link
G Sod1 superoxide dismutase 1, soluble increases abundance
decreases abundance
multiple interactions
decreases chemical synthesis
EXP
ISO
SOD1 protein results in increased abundance of Superoxides
SOD1 protein results in decreased abundance of Superoxides
[[Chelating Agents binds to Copper] which affects the activity of SOD1 protein] which results in increased abundance of Superoxides; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Nitric Oxide] which results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]
SOD1 protein results in decreased chemical synthesis of Superoxides
[SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides]
CTD PMID:11756504 PMID:12489993 PMID:15364863 PMID:15829915 PMID:17391658 More... NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases metabolic processing
affects metabolic processing
decreases abundance
multiple interactions
increases expression
affects abundance
affects chemical synthesis
ISO
EXP
SOD2 protein results in increased metabolism of Superoxides
SOD2 protein polymorphism affects the metabolism of Superoxides
SOD2 protein results in decreased abundance of Superoxides
[tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of SOD2 protein; SOD2 protein affects the reaction [Troglitazone results in increased abundance of Superoxides]; SOD2 protein inhibits the reaction [Superoxides results in increased expression of FOS mRNA]; SOD2 protein inhibits the reaction [Superoxides results in increased expression of JUN mRNA]
Superoxides results in increased expression of SOD2 protein
[Rotenone results in increased abundance of Superoxides] which results in increased expression of SOD2 protein; [TNF protein results in increased expression of SOD2 protein] which results in decreased susceptibility to Superoxides; SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
[SOD2 protein results in increased metabolism of Superoxides] which results in increased chemical synthesis of Hydrogen Peroxide; Tamoxifen inhibits the reaction [SOD2 protein affects the abundance of Superoxides]
SOD2 protein affects the chemical synthesis of Superoxides
CTD PMID:1850207 PMID:9067545 PMID:11050244 PMID:16179351 PMID:17150972 More... NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sod3 superoxide dismutase 3, extracellular multiple interactions EXP [ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; [Streptozocin results in decreased activity of SOD3 protein] which results in increased chemical synthesis of Superoxides; SOD3 gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides] CTD PMID:16864745 PMID:23884884 NCBI chr 5:52,363,804...52,369,738
Ensembl chr 5:52,363,791...52,371,418
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases secretion
increases abundance
ISO
EXP
Superoxides affects the reaction [Glucose results in increased expression of TGFB1 mRNA]
Superoxides results in increased secretion of TGFB1 protein
[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; CAT protein inhibits the reaction [Superoxides results in increased secretion of TGFB1 protein]
TGFB1 protein results in increased abundance of Superoxides
CTD PMID:12606818 PMID:16572112 PMID:19268487 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects abundance
decreases abundance
increases abundance
ISO
EXP
[HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein; [N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides; [TNF protein results in increased expression of SOD2 protein] which results in decreased susceptibility to Superoxides; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Acetylcysteine inhibits the reaction [TNF protein results in increased abundance of Superoxides]; cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Cyclosporine inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Tacrolimus inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]
TNF protein affects the abundance of Superoxides
TNF gene mutant form results in decreased abundance of Superoxides
TNF protein inhibits the reaction [Dichloroacetic Acid results in increased abundance of Superoxides]
CTD PMID:1850207 PMID:11121130 PMID:11313892 PMID:15450858 PMID:19478208 More... NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides] CTD PMID:20457604 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; [TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Dinitrochlorobenzene promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Dithionitrobenzoic Acid inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; formic acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Oxygen deficiency inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Pentetic Acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Sodium Selenite inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides] CTD PMID:20457604 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) multiple interactions ISO UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein] CTD PMID:11050244 NCBI chr 8:83,290,348...83,298,456
Ensembl chr 8:83,290,352...83,298,452
JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions
decreases abundance
ISO [[benzo(a)pyrene-1,6-quinone results in increased abundance of Superoxides] co-treated with [benzo(a)pyrene-1,6-quinone results in decreased abundance of Hydrogen Peroxide]] results in increased expression of UCP2 mRNA
UCP2 protein results in decreased abundance of Superoxides
CTD PMID:10860543 PMID:25440059 NCBI chr 7:100,493,337...100,499,629
Ensembl chr 7:100,493,337...100,502,020
JBrowse link
G Vav2 vav 2 oncogene multiple interactions
increases abundance
EXP 2-acetylphenothiazine inhibits the reaction [VAV2 protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [VAV2 protein results in increased abundance of Superoxides] CTD PMID:23940720 NCBI chr 2:27,262,104...27,427,608
Ensembl chr 2:27,262,104...27,427,033
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor decreases abundance EXP VDR protein results in decreased abundance of Superoxides CTD PMID:25201890 NCBI chr15:97,854,427...97,908,296
Ensembl chr15:97,854,425...97,910,630
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases chemical synthesis
ISO [[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides] CTD PMID:19268487 PMID:19555678 NCBI chr17:73,883,895...73,950,397
Ensembl chr17:73,883,895...73,950,196
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 21797
    chemical entity 21795
      molecular entity 21782
        radical 398
          radical ion 96
            chloridoaluminium(1+) 0
            inorganic radical ion + 96
            organic radical ion + 0
            radical anion + 96
            radical cation + 0
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