Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:radical ion
go back to main search page
Accession:CHEBI:36875 term browser browse the term
Definition:A radical that carries an electric charge.
Synonyms:related_synonym: radical ions


show annotations for term's descendants           Sort by:
 
superoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 multiple interactions ISO ABCC1 protein affects the reaction [AGT protein results in increased abundance of Superoxides] CTD PMID:17272743 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,138...16,143,257
JBrowse link
G ACO1 aconitase 1 multiple interactions
decreases activity
ISO [SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein
Superoxides results in decreased activity of ACO1 protein
CTD PMID:28542246 NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769
JBrowse link
G ACO2 aconitase 2 multiple interactions
decreases activity
ISO [[[Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron] which co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Hydroxyl Radical; [Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron CTD PMID:16162655 NCBI chr22:41,468,756...41,528,979
Ensembl chr22:41,447,830...41,529,273
JBrowse link
G ADA adenosine deaminase multiple interactions EXP ADA protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides] CTD PMID:10947063 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,619,522...44,652,233
JBrowse link
G AGT angiotensinogen multiple interactions
increases abundance
ISO
EXP
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; ABCC1 protein affects the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; ATOX1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; NOS3 protein affects the reaction [AGT protein results in increased abundance of Superoxides]; Propranolol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides]; SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]
SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]
AGT protein modified form results in increased abundance of Superoxides; AGT protein results in increased abundance of Superoxides
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]
CTD PMID:12606818 PMID:16531806 PMID:16864745 PMID:17272743 PMID:17391658 More... NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G AGTR1 angiotensin II receptor type 1 multiple interactions ISO [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] CTD PMID:23824088 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 multiple interactions EXP [AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone] which results in increased abundance of Superoxides; [AKR1C3 protein results in increased reduction of and affects the activity of benzo(a)pyrene-3,6-quinone] which results in increased chemical synthesis of Superoxides CTD PMID:19442656 PMID:21910479 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 multiple interactions EXP [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of 4-hydroxyequilenin-o-quinone] which results in increased chemical synthesis of Superoxides; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Superoxides CTD PMID:21910479 NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,303,965...19,312,144
JBrowse link
G ALB albumin increases chemical synthesis
multiple interactions
EXP ALB protein modified form results in increased chemical synthesis of Superoxides
Etomidate promotes the reaction [ALB protein modified form results in increased chemical synthesis of Superoxides]
CTD PMID:25421967 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G ALDH5A1 aldehyde dehydrogenase 5 family member A1 multiple interactions ISO [ALDH5A1 gene mutant form results in increased susceptibility to 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one] which results in increased abundance of Superoxides; [ALDH5A1 gene mutant form results in increased susceptibility to NCS 382] which results in increased abundance of Superoxides CTD PMID:29031482 NCBI chr 6:24,494,969...24,537,207
Ensembl chr 6:24,494,867...24,537,207
JBrowse link
G APOE apolipoprotein E increases chemical synthesis
increases abundance
multiple interactions
ISO APOE gene mutant form results in increased chemical synthesis of Superoxides
APOE gene mutant form results in increased abundance of Superoxides
imisopasem manganese inhibits the reaction [APOE gene mutant form results in increased chemical synthesis of Superoxides]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [APOE gene mutant form results in increased abundance of Superoxides]
CTD PMID:11397713 PMID:12871831 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G APP amyloid beta precursor protein multiple interactions
increases chemical synthesis
EXP 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; GW 501516 inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; resveratrol inhibits the reaction [APP protein results in increased abundance of Superoxides] CTD PMID:16212921 PMID:22886847 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AR androgen receptor multiple interactions EXP Superoxides promotes the reaction [methylselenic acid results in decreased expression of AR protein] CTD PMID:16928829 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ARF6 ADP ribosylation factor 6 multiple interactions EXP 1-Butanol inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 1-Butanol inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]; ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides] CTD PMID:10931844 NCBI chr14:49,893,082...49,897,054
Ensembl chr14:49,893,082...49,897,054
JBrowse link
G ARRB2 arrestin beta 2 affects abundance ISO ARRB2 protein affects the abundance of Superoxides CTD PMID:16210646 NCBI chr17:4,710,619...4,721,500
Ensembl chr17:4,710,596...4,721,499
JBrowse link
G ATOX1 antioxidant 1 copper chaperone multiple interactions ISO ATOX1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides] CTD PMID:22753205 NCBI chr 5:151,742,822...151,758,631
Ensembl chr 5:151,742,316...151,772,532
JBrowse link
G ATP7A ATPase copper transporting alpha increases abundance
multiple interactions
ISO ATP7A mutant form results in increased abundance of Superoxides
[ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; ATP7A gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; ATP7A protein inhibits the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]
CTD PMID:18768397 PMID:23884884 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,656...78,050,395
JBrowse link
G C5 complement C5 multiple interactions
increases abundance
EXP 8-(4-sulfophenyl)theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline inhibits the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides] CTD PMID:10947063 NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,952,335...121,050,275
JBrowse link
G CAT catalase multiple interactions EXP CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; CAT protein inhibits the reaction [Superoxides results in increased secretion of TGFB1 protein] CTD PMID:19268487 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CBS cystathionine beta-synthase affects abundance
multiple interactions
ISO CBS protein affects the abundance of Superoxides
SMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides]
CTD PMID:23024785 NCBI chr21:43,053,190...43,076,873
Ensembl chr21:43,053,191...43,076,943
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
increases expression
EXP
ISO
Superoxides affects the reaction [Fructose results in increased secretion of CCL2 protein]
Superoxides results in increased expression of CCL2 mRNA
1,3-dimethylthiourea inhibits the reaction [Superoxides results in increased expression of CCL2 mRNA]
CTD PMID:8856246 PMID:19158351 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CD38 CD38 molecule affects localization
multiple interactions
ISO Superoxides affects the localization of CD38 protein
tempol inhibits the reaction [Superoxides affects the localization of CD38 protein]
CTD PMID:23940720 NCBI chr 4:15,778,328...15,853,232
Ensembl chr 4:15,778,275...15,853,232
JBrowse link
G CRP C-reactive protein multiple interactions ISO CRP protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] CTD PMID:9767445 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CYBA cytochrome b-245 alpha chain multiple interactions
increases abundance
EXP
ISO
CYBA protein promotes the reaction [arsenite results in increased abundance of Superoxides]
CYBA protein results in increased abundance of Superoxides
CTD PMID:10720412 PMID:14871555 PMID:20523355 NCBI chr16:88,643,289...88,651,079
Ensembl chr16:88,643,289...88,651,054
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO
EXP
CYBB mutant form inhibits the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein affects the reaction [Folic Acid deficiency results in increased chemical synthesis of Superoxides]; CYBB protein affects the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein promotes the reaction [[Doxorubicin co-treated with NADP] results in increased abundance of Superoxides]
IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides]
CTD PMID:16354686 PMID:17275678 PMID:20116427 PMID:21647593 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases abundance ISO CYP1A1 protein results in increased abundance of Superoxides CTD PMID:20634294 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G DCXR dicarbonyl and L-xylulose reductase increases chemical synthesis
multiple interactions
EXP DCXR protein results in increased chemical synthesis of Superoxides
[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides; Diacetyl inhibits the reaction [[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides]
CTD PMID:28595002 NCBI chr17:82,035,858...82,037,697
Ensembl chr17:82,035,136...82,037,709
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases abundance
increases expression
multiple interactions
ISO DDIT3 protein results in increased abundance of Superoxides
Superoxides results in increased expression of DDIT3 mRNA; Superoxides results in increased expression of DDIT3 protein
[DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 protein; [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein
CTD PMID:16400006 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G EDN1 endothelin 1 multiple interactions
increases abundance
ISO [EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides; Catechin inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]; NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]; Polyphenols inhibits the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]
NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]
CTD PMID:20977430 PMID:23940720 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EDNRA endothelin receptor type A affects abundance ISO EDNRA protein affects the abundance of Superoxides CTD PMID:12600921 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954
JBrowse link
G EP300 E1A binding protein p300 decreases abundance EXP EP300 protein results in decreased abundance of Superoxides CTD PMID:25440059 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077
JBrowse link
G EPO erythropoietin multiple interactions ISO EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides] CTD PMID:25490417 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700
JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor multiple interactions
decreases abundance
increases abundance
EXP 3-aminobenzamide inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; NU 1025 inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]
ERCC6 protein results in decreased abundance of Superoxides
CTD PMID:25440059 NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,168...49,539,538
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol binds to and results in increased activity of ESR1 protein] which results in decreased abundance of Superoxides; [ESR1 protein results in increased susceptibility to Estradiol] which results in increased abundance of Superoxides; ESR1 protein affects the reaction [Estradiol results in decreased chemical synthesis of Superoxides] CTD PMID:18354059 PMID:23000059 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G FMR1 FMRP translational regulator 1 multiple interactions
increases abundance
EXP Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [FMR1 5' UTR mutant form results in increased abundance of Superoxides] CTD PMID:27385396 NCBI chr  X:147,911,919...147,951,125
Ensembl chr  X:147,911,919...147,951,125
JBrowse link
G FN1 fibronectin 1 multiple interactions ISO Superoxides affects the reaction [Glucose results in increased expression of FN1 mRNA] CTD PMID:16572112 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO SOD2 protein inhibits the reaction [Superoxides results in increased expression of FOS mRNA] CTD PMID:9067545 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP
ISO
SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
CTD PMID:11050244 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
JBrowse link
G GAS5 growth arrest specific 5 increases expression ISO Superoxides results in increased expression of GAS5 mRNA; Superoxides results in increased expression of GAS5 protein CTD PMID:16400006 NCBI chr 1:173,863,899...173,868,882
Ensembl chr 1:173,858,559...173,868,882
JBrowse link
G GCH1 GTP cyclohydrolase 1 affects abundance ISO GCH1 protein affects the abundance of Superoxides CTD PMID:21963838 NCBI chr14:54,842,016...54,902,826
Ensembl chr14:54,842,008...54,902,826
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
decreases abundance
increases abundance
ISO
EXP
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; Deferoxamine inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]
HMOX1 protein results in decreased abundance of Superoxides
[tetrathiomolybdate analog results in increased abundance of Superoxides] which results in increased reduction of HMOX1 protein
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; [cobaltous chloride results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; [stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Superoxides; [tin mesoporphyrin results in decreased activity of HMOX1 protein] which results in increased abundance of Superoxides; Deferoxamine inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]
CTD PMID:15821039 PMID:16959961 PMID:18073186 PMID:18178725 PMID:18334666 More... NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HRAS HRas proto-oncogene, GTPase increases abundance
multiple interactions
EXP HRAS protein mutant form results in increased abundance of Superoxides
[HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein
CTD PMID:11313892 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 multiple interactions
decreases abundance
ISO [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of HSPB1 protein
HSPB1 protein results in decreased abundance of Superoxides
CTD PMID:14975446 PMID:19193722 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
JBrowse link
G IER3 immediate early response 3 affects chemical synthesis ISO IER3 protein affects the chemical synthesis of Superoxides CTD PMID:20713914 NCBI chr 6:30,743,199...30,744,547
Ensembl chr 6:30,743,199...30,744,548
JBrowse link
G IGF1 insulin like growth factor 1 decreases abundance EXP IGF1 protein results in decreased abundance of Superoxides CTD PMID:22843358 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases abundance
EXP diphenyleneiodonium inhibits the reaction [IL1B protein results in increased abundance of Superoxides]; IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides] CTD PMID:16354686 PMID:21211511 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL5 interleukin 5 multiple interactions EXP 1-Methyl-3-isobutylxanthine promotes the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]; Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]; ICI 118551 inhibits the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]] CTD PMID:16238794 NCBI chr 5:132,539,194...132,556,864
Ensembl chr 5:132,541,445...132,556,838
JBrowse link
G ITGA3 integrin subunit alpha 3 multiple interactions ISO [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 protein CTD PMID:16400006 NCBI chr17:50,056,065...50,090,481
Ensembl chr17:50,055,968...50,090,481
JBrowse link
G ITGB1 integrin subunit beta 1 multiple interactions ISO [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein CTD PMID:16400006 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO Superoxides affects the reaction [Glucose results in increased phosphorylation of JUN protein]
Superoxides results in increased expression of JUN mRNA
SOD2 protein inhibits the reaction [Superoxides results in increased expression of JUN mRNA]
CTD PMID:9067545 PMID:16572112 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G KAT2A lysine acetyltransferase 2A decreases abundance EXP KAT2A protein results in decreased abundance of Superoxides CTD PMID:25440059 NCBI chr17:42,113,111...42,121,367
Ensembl chr17:42,113,111...42,121,367
JBrowse link
G KAT2B lysine acetyltransferase 2B decreases abundance EXP KAT2B protein results in decreased abundance of Superoxides CTD PMID:25440059 NCBI chr 3:20,040,407...20,154,404
Ensembl chr 3:20,040,446...20,154,404
JBrowse link
G KDR kinase insert domain receptor increases phosphorylation EXP Superoxides results in increased phosphorylation of KDR protein CTD PMID:19571580 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G LEP leptin multiple interactions
increases abundance
ISO
EXP
acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]; BQ 788 inhibits the reaction [LEP protein results in increased abundance of Superoxides]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased abundance of Superoxides]
[LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides
CTD PMID:11342529 PMID:16380530 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LEPR leptin receptor multiple interactions
increases abundance
ISO acetovanillone inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides]; resveratrol inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides] CTD PMID:19478208 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G LPA lipoprotein(a) multiple interactions EXP [[Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein] which results in decreased secretion of SERPINE1 protein; [Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein CTD PMID:11681624 NCBI chr 6:160,531,482...160,664,275
Ensembl chr 6:160,531,482...160,664,275
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
Superoxides results in increased phosphorylation of MAPK1 protein
CTD PMID:16572112 PMID:19268487 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
Superoxides results in increased phosphorylation of MAPK3 protein
CTD PMID:16572112 PMID:19268487 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation ISO Superoxides results in increased phosphorylation of MAPK8 protein CTD PMID:33290831 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation ISO Superoxides results in increased phosphorylation of MAPK9 protein CTD PMID:33290831 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G MPO myeloperoxidase multiple interactions EXP [MPO protein results in increased oxidation of hydrazine] which results in increased chemical synthesis of Superoxides CTD PMID:26867495 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MT3 metallothionein 3 decreases response to substance EXP MT3 protein results in decreased susceptibility to Superoxides CTD PMID:12383939 NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088
JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions ISO NCF1 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides] CTD PMID:17448908 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,773,962...74,789,376
JBrowse link
G NCF2 neutrophil cytosolic factor 2 multiple interactions ISO NCF2 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides] CTD PMID:17448908 NCBI chr 1:183,555,562...183,590,914
Ensembl chr 1:183,555,562...183,590,876
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO [Ozone results in increased expression of NOS2 protein] which results in increased abundance of Superoxides CTD PMID:11919077 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
affects chemical synthesis
decreases abundance
increases abundance
EXP
ISO
7,8-dihydrobiopterin promotes the reaction [NOS3 protein results in increased abundance of Superoxides]; [Equol results in increased chemical synthesis of Superoxides] which results in increased activity of and results in increased phosphorylation of NOS3 protein; sapropterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides]; sapropterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Equol results in increased chemical synthesis of Superoxides] which results in increased phosphorylation of NOS3 protein]
NOS3 protein affects the chemical synthesis of Superoxides
NOS3 protein results in decreased abundance of Superoxides
[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]; NOS3 protein affects the reaction [AGT protein results in increased abundance of Superoxides]
[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides; Nitroglycerin promotes the reaction [[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides]; NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]
CTD PMID:10625313 PMID:17272743 PMID:18714161 PMID:19011239 PMID:19696404 More... NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G NOX1 NADPH oxidase 1 multiple interactions
increases abundance
ISO [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]; NOX1 mRNA promotes the reaction [Tobacco Smoke Pollution results in increased chemical synthesis of Superoxides]
diphenyleneiodonium inhibits the reaction [NOX1 protein results in increased abundance of Superoxides]; NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]
CTD PMID:23824088 PMID:23940720 PMID:24912985 PMID:27816504 NCBI chr  X:100,843,324...100,874,359
Ensembl chr  X:100,843,324...100,874,359
JBrowse link
G NOX3 NADPH oxidase 3 multiple interactions ISO [resveratrol results in decreased expression of and results in decreased activity of NOX3 protein] which results in decreased abundance of Superoxides CTD PMID:20675566 NCBI chr 6:155,395,368...155,455,839
Ensembl chr 6:155,395,368...155,455,839
JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions EXP NOX4 promotes the reaction [sodium arsenite results in increased abundance of Superoxides] CTD PMID:26535918 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
JBrowse link
G PARK7 Parkinsonism associated deglycase multiple interactions ISO PARK7 protein affects the reaction [Paraquat results in increased abundance of Superoxides] CTD PMID:21300143 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505
JBrowse link
G PDHA1 pyruvate dehydrogenase E1 subunit alpha 1 affects abundance EXP PDHA1 protein affects the abundance of Superoxides CTD PMID:21846590 NCBI chr  X:19,343,906...19,361,718
Ensembl chr  X:19,343,893...19,361,718
JBrowse link
G PINK1 PTEN induced kinase 1 affects abundance ISO PINK1 protein affects the abundance of Superoxides CTD PMID:21421046 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511
JBrowse link
G POLG DNA polymerase gamma, catalytic subunit multiple interactions
increases chemical synthesis
ISO Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin inhibits the reaction [POLG protein results in increased chemical synthesis of Superoxides]; polyethylene glycol-superoxide dismutase inhibits the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides]; Rotenone promotes the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides] CTD PMID:30038268 NCBI chr15:89,316,320...89,334,824
Ensembl chr15:89,305,198...89,334,861
JBrowse link
G POMC proopiomelanocortin increases abundance ISO POMC protein results in increased abundance of Superoxides CTD PMID:16620303 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G PON2 paraoxonase 2 increases expression ISO Superoxides results in increased expression of PON2 protein CTD PMID:15544923 NCBI chr 7:95,404,862...95,435,028
Ensembl chr 7:95,404,862...95,435,329
JBrowse link
G POR cytochrome p450 oxidoreductase multiple interactions EXP
ISO
[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; [POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides]
[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]
CTD PMID:21215309 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
JBrowse link
G PRKCA protein kinase C alpha multiple interactions EXP [Ethanol results in increased localization of and results in increased activity of PRKCA protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] CTD PMID:10651808 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G PRKCB protein kinase C beta multiple interactions EXP [Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] CTD PMID:10651808 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO resveratrol inhibits the reaction [Superoxides results in increased expression of PTGS2 protein] CTD PMID:10718345 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions EXP [resveratrol results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides CTD PMID:21544240 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G SELENOH selenoprotein H decreases abundance EXP SELENOH protein results in decreased abundance of Superoxides CTD PMID:17389926 NCBI chr11:57,741,491...57,743,550
Ensembl chr11:57,741,250...57,743,554
JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions EXP [[Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein] which results in decreased secretion of SERPINE1 protein CTD PMID:11681624 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Superoxides]] CTD PMID:18424637 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SLC25A14 solute carrier family 25 member 14 multiple interactions EXP SLC25A14 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased abundance of Superoxides]; SLC25A14 protein inhibits the reaction [Dopamine results in increased abundance of Superoxides] CTD PMID:20600837 NCBI chr  X:130,339,892...130,373,360
Ensembl chr  X:130,339,888...130,373,361
JBrowse link
G SMPD1 sphingomyelin phosphodiesterase 1 multiple interactions ISO SMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides] CTD PMID:23024785 NCBI chr11:6,390,474...6,394,998
Ensembl chr11:6,390,440...6,394,998
JBrowse link
G SOD1 superoxide dismutase 1 increases abundance
decreases abundance
multiple interactions
decreases chemical synthesis
ISO
EXP
SOD1 protein results in increased abundance of Superoxides
SOD1 protein results in decreased abundance of Superoxides
[[Chelating Agents binds to Copper] which affects the activity of SOD1 protein] which results in increased abundance of Superoxides; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Nitric Oxide] which results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]
SOD1 protein results in decreased chemical synthesis of Superoxides
[SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides]
CTD PMID:11756504 PMID:12489993 PMID:15364863 PMID:15829915 PMID:17391658 More... NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 increases metabolic processing
affects metabolic processing
decreases abundance
multiple interactions
increases expression
affects abundance
affects chemical synthesis
EXP
ISO
SOD2 protein results in increased metabolism of Superoxides
SOD2 protein polymorphism affects the metabolism of Superoxides
SOD2 protein results in decreased abundance of Superoxides
[tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of SOD2 protein; SOD2 protein affects the reaction [troglitazone results in increased abundance of Superoxides]; SOD2 protein inhibits the reaction [Superoxides results in increased expression of FOS mRNA]; SOD2 protein inhibits the reaction [Superoxides results in increased expression of JUN mRNA]
Superoxides results in increased expression of SOD2 protein
[Rotenone results in increased abundance of Superoxides] which results in increased expression of SOD2 protein; [TNF protein results in increased expression of SOD2 protein] which results in decreased susceptibility to Superoxides; SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
[SOD2 protein results in increased metabolism of Superoxides] which results in increased chemical synthesis of Hydrogen Peroxide; Tamoxifen inhibits the reaction [SOD2 protein affects the abundance of Superoxides]
SOD2 protein affects the chemical synthesis of Superoxides
CTD PMID:1850207 PMID:9067545 PMID:11050244 PMID:16179351 PMID:17150972 More... NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOD3 superoxide dismutase 3 multiple interactions ISO [ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; [Streptozocin results in decreased activity of SOD3 protein] which results in increased chemical synthesis of Superoxides; SOD3 gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides] CTD PMID:16864745 PMID:23884884 NCBI chr 4:24,795,478...24,800,845
Ensembl chr 4:24,789,912...24,800,842
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
increases secretion
increases abundance
ISO
EXP
Superoxides affects the reaction [Glucose results in increased expression of TGFB1 mRNA]
Superoxides results in increased secretion of TGFB1 protein
[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; CAT protein inhibits the reaction [Superoxides results in increased secretion of TGFB1 protein]
TGFB1 protein results in increased abundance of Superoxides
CTD PMID:12606818 PMID:16572112 PMID:19268487 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions
affects abundance
decreases abundance
increases abundance
EXP
ISO
[HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein; [N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides; [TNF protein results in increased expression of SOD2 protein] which results in decreased susceptibility to Superoxides; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Acetylcysteine inhibits the reaction [TNF protein results in increased abundance of Superoxides]; cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Cyclosporine inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Tacrolimus inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]
TNF protein affects the abundance of Superoxides
TNF gene mutant form results in decreased abundance of Superoxides
TNF protein inhibits the reaction [Dichloroacetic Acid results in increased abundance of Superoxides]
CTD PMID:1850207 PMID:11121130 PMID:11313892 PMID:15450858 PMID:19478208 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TXN thioredoxin multiple interactions ISO [TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides] CTD PMID:20457604 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
G TXNRD1 thioredoxin reductase 1 multiple interactions ISO [TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; [TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Dinitrochlorobenzene promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Dithionitrobenzoic Acid inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; formic acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Oxygen deficiency inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Pentetic Acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Sodium Selenite inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides] CTD PMID:20457604 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G UCP1 uncoupling protein 1 multiple interactions ISO UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein] CTD PMID:11050244 NCBI chr 4:140,555,770...140,568,961
Ensembl chr 4:140,559,431...140,568,961
JBrowse link
G UCP2 uncoupling protein 2 multiple interactions
decreases abundance
ISO
EXP
[[benzo(a)pyrene-1,6-quinone results in increased abundance of Superoxides] co-treated with [benzo(a)pyrene-1,6-quinone results in decreased abundance of Hydrogen Peroxide]] results in increased expression of UCP2 mRNA
UCP2 protein results in decreased abundance of Superoxides
CTD PMID:10860543 PMID:25440059 NCBI chr11:73,974,671...73,983,202
Ensembl chr11:73,974,672...73,982,843
JBrowse link
G VAV2 vav guanine nucleotide exchange factor 2 multiple interactions
increases abundance
ISO 2-acetylphenothiazine inhibits the reaction [VAV2 protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [VAV2 protein results in increased abundance of Superoxides] CTD PMID:23940720 NCBI chr 9:133,761,894...133,992,374
Ensembl chr 9:133,761,894...133,992,604
JBrowse link
G VDR vitamin D receptor decreases abundance ISO VDR protein results in decreased abundance of Superoxides CTD PMID:25201890 NCBI chr12:47,841,537...47,905,022
Ensembl chr12:47,841,537...47,943,048
JBrowse link
G XDH xanthine dehydrogenase multiple interactions
increases chemical synthesis
EXP [[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides] CTD PMID:19268487 PMID:19555678 NCBI chr 2:31,334,320...31,414,777
Ensembl chr 2:31,334,321...31,414,742
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24838
    chemical entity 24808
      molecular entity 24774
        radical 400
          radical ion 97
            chloridoaluminium(1+) 0
            inorganic radical ion + 97
            organic radical ion + 0
            radical anion + 97
            radical cation + 0
paths to the root