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G
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Abcb11
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ATP binding cassette subfamily B member 11
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decreases expression
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EXP
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chrysophanic acid results in decreased expression of ABCB11 mRNA; chrysophanic acid results in decreased expression of ABCB11 protein
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CTD |
PMID:28161596 |
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NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
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G
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Abcc2
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ATP binding cassette subfamily C member 2
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increases expression
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EXP
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chrysophanic acid results in increased expression of ABCC2 mRNA; chrysophanic acid results in increased expression of ABCC2 protein
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CTD |
PMID:28161596 |
|
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
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G
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Abcc4
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ATP binding cassette subfamily C member 4
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increases expression
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EXP
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chrysophanic acid results in increased expression of ABCC4 mRNA; chrysophanic acid results in increased expression of ABCC4 protein
|
CTD |
PMID:28161596 |
|
NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375
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G
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Ahr
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aryl hydrocarbon receptor
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multiple interactions
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ISO
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chrysophanic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
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CTD |
PMID:19269596 |
|
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
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G
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Akt1
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AKT serine/threonine kinase 1
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decreases phosphorylation
|
ISO
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chrysophanic acid results in decreased phosphorylation of AKT1 protein
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CTD |
PMID:30300626 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
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G
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Bak1
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BCL2-antagonist/killer 1
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increases expression
|
ISO
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chrysophanic acid results in increased expression of BAK1 protein
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CTD |
PMID:30300626 |
|
NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974
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G
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Bax
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BCL2 associated X, apoptosis regulator
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increases expression
|
ISO
|
chrysophanic acid results in increased expression of BAX protein
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CTD |
PMID:30300626 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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G
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Cyp1a1
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cytochrome P450, family 1, subfamily a, polypeptide 1
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decreases activity
|
ISO
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chrysophanic acid results in decreased activity of CYP1A1 protein
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CTD |
PMID:27633141 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
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G
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Cyp1a2
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cytochrome P450, family 1, subfamily a, polypeptide 2
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decreases activity multiple interactions increases metabolic processing
|
ISO
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chrysophanic acid results in decreased activity of CYP1A2 protein [CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol
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CTD |
PMID:27633141 PMID:29698620 PMID:33438235 |
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NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
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G
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Cyp1b1
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cytochrome P450, family 1, subfamily b, polypeptide 1
|
decreases activity
|
ISO
|
chrysophanic acid results in decreased activity of CYP1B1 protein
|
CTD |
PMID:27633141 |
|
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
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G
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Cyp2b3
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cytochrome P450, family 2, subfamily b, polypeptide 3
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multiple interactions increases metabolic processing
|
ISO
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[CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
|
CTD |
PMID:29698620 |
|
NCBI chr 1:90,780,468...90,859,852
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G
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Cyp3a2
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cytochrome P450, family 3, subfamily a, polypeptide 2
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increases metabolic processing increases chemical synthesis multiple interactions
|
ISO
|
CYP3A4 protein results in increased metabolism of chrysophanic acid CYP3A4 protein results in increased chemical synthesis of chrysophanic acid metabolite [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol; [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
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CTD |
PMID:29698620 |
|
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
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G
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Cyp7a1
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cytochrome P450 family 7 subfamily A member 1
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increases expression
|
EXP
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chrysophanic acid results in increased expression of CYP7A1 mRNA; chrysophanic acid results in increased expression of CYP7A1 protein
|
CTD |
PMID:28161596 |
|
NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202
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G
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Cyp8b1
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cytochrome P450 family 8 subfamily B member 1
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decreases expression
|
EXP
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chrysophanic acid results in decreased expression of CYP8B1 mRNA; chrysophanic acid results in decreased expression of CYP8B1 protein
|
CTD |
PMID:28161596 |
|
NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689
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G
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Ddit3
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DNA-damage inducible transcript 3
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increases expression
|
ISO
|
chrysophanic acid results in increased expression of DDIT3 protein
|
CTD |
PMID:30300626 |
|
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
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G
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Eif2ak3
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eukaryotic translation initiation factor 2 alpha kinase 3
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increases phosphorylation multiple interactions
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ISO
|
chrysophanic acid results in increased phosphorylation of EIF2AK3 protein Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2AK3 protein]
|
CTD |
PMID:30300626 |
|
NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
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G
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Eif2s1
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eukaryotic translation initiation factor 2 subunit alpha
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increases phosphorylation multiple interactions
|
ISO
|
chrysophanic acid results in increased phosphorylation of EIF2S1 protein Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2S1 protein]
|
CTD |
PMID:30300626 |
|
NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649
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G
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Ern1
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endoplasmic reticulum to nucleus signaling 1
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increases expression
|
ISO
|
chrysophanic acid results in increased expression of ERN1 protein
|
CTD |
PMID:30300626 |
|
NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791
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G
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Mapk1
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mitogen activated protein kinase 1
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decreases phosphorylation
|
ISO
|
chrysophanic acid results in decreased phosphorylation of MAPK1 protein
|
CTD |
PMID:30300626 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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G
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Mapk14
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mitogen activated protein kinase 14
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affects phosphorylation
|
ISO
|
chrysophanic acid affects the phosphorylation of MAPK14 protein
|
CTD |
PMID:30300626 |
|
NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294
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G
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Mapk3
|
mitogen activated protein kinase 3
|
decreases phosphorylation
|
ISO
|
chrysophanic acid results in decreased phosphorylation of MAPK3 protein
|
CTD |
PMID:30300626 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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G
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Mapk8
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mitogen-activated protein kinase 8
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affects phosphorylation
|
ISO
|
chrysophanic acid affects the phosphorylation of MAPK8 protein
|
CTD |
PMID:30300626 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
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G
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Pcna
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proliferating cell nuclear antigen
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decreases expression
|
ISO
|
chrysophanic acid results in decreased expression of PCNA protein
|
CTD |
PMID:30300626 |
|
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901
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G
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Rps6
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ribosomal protein S6
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decreases phosphorylation
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ISO
|
chrysophanic acid results in decreased phosphorylation of RPS6 protein
|
CTD |
PMID:30300626 |
|
NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566
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G
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Rps6kb1
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ribosomal protein S6 kinase B1
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decreases phosphorylation
|
ISO
|
chrysophanic acid results in decreased phosphorylation of RPS6KB1 protein
|
CTD |
PMID:30300626 |
|
NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238
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G
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Slc10a1
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solute carrier family 10 member 1
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decreases expression
|
EXP
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chrysophanic acid results in decreased expression of SLC10A1 mRNA; chrysophanic acid results in decreased expression of SLC10A1 protein
|
CTD |
PMID:28161596 |
|
NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944
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G
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Slc22a6
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solute carrier family 22 member 6
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decreases activity
|
ISO
|
chrysophanic acid results in decreased activity of SLC22A6 protein
|
CTD |
PMID:29045746 |
|
NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311
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G
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Slc22a8
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solute carrier family 22 member 8
|
decreases activity
|
ISO
|
chrysophanic acid results in decreased activity of SLC22A8 protein
|
CTD |
PMID:29045746 |
|
NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588
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G
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Sult1a1
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sulfotransferase family 1A member 1
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decreases activity
|
ISO
|
chrysophanic acid results in decreased activity of SULT1A1 protein
|
CTD |
PMID:27633141 |
|
NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131
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G
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Ugt1a9
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UDP glucuronosyltransferase family 1 member A9
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increases glucuronidation
|
ISO
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UGT1A9 protein results in increased glucuronidation of chrysophanic acid
|
CTD |
PMID:24854283 |
|
NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
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|
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G
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Cyp1a2
|
cytochrome P450, family 1, subfamily a, polypeptide 2
|
increases chemical synthesis multiple interactions
|
ISO
|
CYP1A2 protein results in increased chemical synthesis of 2-hydroxychrysophanol [CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol
|
CTD |
PMID:29698620 |
|
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
|
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G
|
Cyp3a2
|
cytochrome P450, family 3, subfamily a, polypeptide 2
|
multiple interactions increases chemical synthesis
|
ISO
|
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol CYP3A4 protein results in increased chemical synthesis of 2-hydroxychrysophanol
|
CTD |
PMID:29698620 |
|
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
|
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