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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:24-hydroxy steroid
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Accession:CHEBI:36865 term browser browse the term
Synonyms:related_synonym: 24-hydroxy steroids


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(24S)-24-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO 24-hydroxycholesterol results in increased expression of ABCA1 mRNA; 24-hydroxycholesterol results in increased expression of ABCA1 protein CTD PMID:15148325, PMID:19126211 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO 24-hydroxycholesterol results in increased expression of ABCG1 protein CTD PMID:19126211 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases metabolic processing
ISO 24-hydroxycholesterol affects the metabolism of and results in increased activity of APP protein; 24-hydroxycholesterol results in decreased metabolism of and results in decreased secretion of APP protein
24-hydroxycholesterol results in increased metabolism of APP protein
CTD PMID:15148325, PMID:17532301, PMID:19126211 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
ISO 24-hydroxycholesterol results in increased expression of CCL2 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA; Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of CCL2 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA]
CTD PMID:24802026 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions
ISO 24-hydroxycholesterol results in increased expression of CD36 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA; Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of CD36 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA]
CTD PMID:24802026 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases abundance ISO CYP27A1 protein results in decreased abundance of 24-hydroxycholesterol CTD PMID:12119285 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 increases metabolic processing ISO CYP39A1 protein results in increased metabolism of 24-hydroxycholesterol CTD PMID:10748047 NCBI chr 9:19,804,079...19,880,346
Ensembl chr 9:19,804,079...19,880,346
JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 affects abundance
increases chemical synthesis
increases metabolic processing
ISO CYP46A1 gene SNP affects the abundance of 24-hydroxycholesterol
CYP46A1 protein results in increased chemical synthesis of 24-hydroxycholesterol
CYP46A1 protein results in increased metabolism of 24-hydroxycholesterol
CTD PMID:14640697, PMID:19286353 NCBI chr 6:132,242,328...132,273,788
Ensembl chr 6:132,242,328...132,273,787
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing ISO CYP7A1 protein results in increased metabolism of 24-hydroxycholesterol CTD PMID:11013305 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 24-hydroxycholesterol binds to and results in decreased activity of ESR1 protein; 24-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:17873880 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO 24-hydroxycholesterol binds to and results in decreased activity of ESR2 protein; 24-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:17873880 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity ISO 24-hydroxycholesterol results in decreased activity of HMGCR protein CTD PMID:7751816 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Itgb1 integrin subunit beta 1 increases expression
multiple interactions
ISO 24-hydroxycholesterol results in increased expression of ITGB1 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA; Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of ITGB1 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]; Quercetin inhibits the reaction [24-hydroxycholesterol results in increased expression of ITGB1 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]
CTD PMID:24802026 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
ISO 24-hydroxycholesterol results in increased expression of MMP9 mRNA
Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of MMP9 mRNA]
CTD PMID:24802026 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO [24-hydroxycholesterol co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA CTD PMID:23732298 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Ptges prostaglandin E synthase multiple interactions
increases expression
ISO Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of PTGES mRNA]; Quercetin inhibits the reaction [24-hydroxycholesterol results in increased expression of PTGES mRNA] CTD PMID:24802026 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO 24-hydroxycholesterol results in increased expression of PTGS2 protein
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of PTGS2 protein
CTD PMID:24802026 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO 24-hydroxycholesterol results in increased expression of and results in increased phosphorylation of TH protein CTD PMID:19014385 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression
ISO [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA; Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [24-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA] CTD PMID:24802026 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19769
      molecular entity 19767
        polyatomic entity 19677
          heteroatomic molecular entity 19594
            hydroxides 19064
              organic hydroxy compound 18631
                hydroxy steroid 12370
                  24-hydroxy steroid 19
                    (24R)-11alpha,20,24-trihydroxyecdysone 0
                    (24S)-24-hydroxycholesterol 3-linoleoate 0
                    (24S)-24-hydroxycholesterol ester + 0
                    (24S)-hydroxycholestanol 0
                    (24S)-hydroxycholesterol 3-sulfate 0
                    (24S,25)-dihydroxycholesterol 0
                    (24S,25S)-cholest-5-en-3beta,24,26-triol 0
                    (24S,26)-dihydroxycholesterol 0
                    24-hydroxycholesterol + 19
                    3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-al + 0
                    3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oic acid + 0
                    3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-al + 0
                    3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oic acid + 0
                    4beta,24S-dihydroxycholesterol 0
                    5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol + 0
                    5beta-cholestane-3alpha,7alpha,12alpha,24,26-pentol + 0
                    5beta-cholestane-3alpha,7alpha,12alpha,24-tetrol + 0
                    5beta-cholestane-3alpha,7alpha,24,26-tetrol + 0
                    5beta-cholestane-3alpha,7alpha,24-triol + 0
                    5beta-scymnol + 0
                    7alpha,12alpha,24-trihydroxy-5beta-cholestan-3-one + 0
                    7alpha,12alpha,24-trihydroxycholest-4-en-3-one + 0
                    7alpha,24-dihydroxy-5beta-cholestan-3-one + 0
                    7alpha,24-dihydroxycholest-4-en-3-one + 0
                    7alpha,24-dihydroxycholesterol + 0
                    cholesta-5,7-dien-3beta,24S-diol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic molecule 19461
                              organic cyclic compound 19232
                                organic polycyclic compound 16381
                                  steroid 12789
                                    hydroxy steroid 12370
                                      24-hydroxy steroid 19
                                        (24R)-11alpha,20,24-trihydroxyecdysone 0
                                        (24S)-24-hydroxycholesterol 3-linoleoate 0
                                        (24S)-24-hydroxycholesterol ester + 0
                                        (24S)-hydroxycholestanol 0
                                        (24S)-hydroxycholesterol 3-sulfate 0
                                        (24S,25)-dihydroxycholesterol 0
                                        (24S,25S)-cholest-5-en-3beta,24,26-triol 0
                                        (24S,26)-dihydroxycholesterol 0
                                        24-hydroxycholesterol + 19
                                        3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-al + 0
                                        3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oic acid + 0
                                        3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-al + 0
                                        3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oic acid + 0
                                        4beta,24S-dihydroxycholesterol 0
                                        5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol + 0
                                        5beta-cholestane-3alpha,7alpha,12alpha,24,26-pentol + 0
                                        5beta-cholestane-3alpha,7alpha,12alpha,24-tetrol + 0
                                        5beta-cholestane-3alpha,7alpha,24,26-tetrol + 0
                                        5beta-cholestane-3alpha,7alpha,24-triol + 0
                                        5beta-scymnol + 0
                                        7alpha,12alpha,24-trihydroxy-5beta-cholestan-3-one + 0
                                        7alpha,12alpha,24-trihydroxycholest-4-en-3-one + 0
                                        7alpha,24-dihydroxy-5beta-cholestan-3-one + 0
                                        7alpha,24-dihydroxycholest-4-en-3-one + 0
                                        7alpha,24-dihydroxycholesterol + 0
                                        cholesta-5,7-dien-3beta,24S-diol 0
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