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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:22-hydroxy steroid
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Accession:CHEBI:36863 term browser browse the term
Synonyms:related_synonym: 22-hydroxy steroids

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20-hydroxyecdysone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] CTD PMID:26048653 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Ecdysterone results in increased expression of BAX protein CTD PMID:33878320 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO Ecdysterone affects the expression of BCL2 protein CTD PMID:33878320 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage		 ISO Ecdysterone results in increased activity of CASP3 protein
Ecdysterone results in increased cleavage of CASP3 protein		 CTD PMID:29126784 PMID:33878320 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] CTD PMID:26048653 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:26048653 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
increases expression		 ISO Ecdysterone results in decreased expression of HSPA5 protein
Ecdysterone results in increased expression of HSPA5 mRNA		 CTD PMID:29126784 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Mtor mechanistic target of rapamycin kinase affects expression ISO Ecdysterone affects the expression of MTOR protein CTD PMID:33878320 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases response to substance		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone		 CTD PMID:26048653 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Ecdysterone results in increased cleavage of PARP1 protein CTD PMID:33878320 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sqstm1 sequestosome 1 affects expression ISO Ecdysterone affects the expression of SQSTM1 protein CTD PMID:33878320 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
brassinolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO brassinolide results in decreased expression of BCL2 protein CTD PMID:17557751 PMID:20833159 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO brassinolide results in decreased expression of BCL2L1 protein CTD PMID:20833159 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO brassinolide results in decreased expression of BID protein CTD PMID:20833159 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression		 ISO brassinolide results in increased activity of CASP3 protein
brassinolide results in increased expression of CASP3 protein modified form		 CTD PMID:17557751 PMID:20833159 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO brassinolide results in decreased expression of CCNB1 protein CTD PMID:20833159 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO brassinolide results in decreased expression of CCND1 protein CTD PMID:20833159 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO brassinolide results in decreased expression of CCNE1 protein CTD PMID:20833159 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO brassinolide results in decreased expression of CDK2 protein CTD PMID:20833159 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO brassinolide results in decreased expression of CDK4 protein CTD PMID:20833159 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO brassinolide results in increased expression of CDKN1A protein CTD PMID:20833159 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO brassinolide results in decreased expression of CDKN1B protein CTD PMID:20833159 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO brassinolide results in decreased expression of ESR1 CTD PMID:20833159 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects localization
decreases expression		 ISO brassinolide affects the localization of ESR2 protein
brassinolide results in decreased expression of ESR2		 CTD PMID:20833159 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO brassinolide results in decreased expression of MDM2 protein CTD PMID:20833159 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO brassinolide results in decreased expression of RB1 protein; brassinolide results in decreased expression of RB1 protein modified form CTD PMID:20833159 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO brassinolide results in increased expression of TP53 protein CTD PMID:20833159 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
ponasterone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 decreases activity
multiple interactions		 EXP ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]		 CTD PMID:16396944 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase affects expression ISO ponasterone A affects the expression of FHIT protein CTD PMID:17019711 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein] CTD PMID:16396944 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO ponasterone A results in increased expression of UGT1A3 protein CTD PMID:17058234 NCBI chr 9:88,791,216...88,808,465 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      molecular entity 19811
        polyatomic entity 19732
          heteroatomic molecular entity 19673
            hydroxides 19175
              organic hydroxy compound 18668
                hydroxy steroid 12657
                  22-hydroxy steroid 28
                    (20R,22R)-20,22-dihydroxycholesterol 0
                    (22R)-22-hydroxycholesterol 0
                    (22S)-22-hydroxycampest-4-en-3-one 0
                    (22S)-22-hydroxycampesterol 0
                    (22S)-22-hydroxycholesterol 0
                    (5alpha,22S,24R)-22-hydroxyergostan-3-one 0
                    (7alpha,22R)-dihydroxycholesterol 0
                    16,23-epoxy-5beta-cholestane triglycoside 0
                    2-deoxyecdysone 0
                    20-hydroxyecdysone 11
                    24-epi-brassinolide 0
                    25-deoxyecdysone 0
                    26-hydroxybrassinolide 0
                    26-hydroxycastasterone 0
                    3-dehydro-6-deoxoteasterone 0
                    3-epi-6-deoxocathasterone 0
                    6-deoxocastasterone 0
                    6-deoxoteasterone 0
                    6-deoxotyphasterol 0
                    6-deoxycathasterone 0
                    brassinolide + 16
                    brassinolide 23-O-alpha-D-glucoside 0
                    castasterone + 0
                    castasterone 23-O-alpha-D-glucoside 0
                    cathasterone + 0
                    ecdysone + 11
                    halosterol A 0
                    halosterol B 0
                    inokosterone 0
                    makisterone B 0
                    podecdysone B 0
                    polypodine B 0
                    ponasterone A 4
                    teasterone + 0
                    typhasterol + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic polycyclic compound 16535
                                  steroid 13057
                                    hydroxy steroid 12657
                                      22-hydroxy steroid 28
                                        (20R,22R)-20,22-dihydroxycholesterol 0
                                        (22R)-22-hydroxycholesterol 0
                                        (22S)-22-hydroxycampest-4-en-3-one 0
                                        (22S)-22-hydroxycampesterol 0
                                        (22S)-22-hydroxycholesterol 0
                                        (5alpha,22S,24R)-22-hydroxyergostan-3-one 0
                                        (7alpha,22R)-dihydroxycholesterol 0
                                        16,23-epoxy-5beta-cholestane triglycoside 0
                                        2-deoxyecdysone 0
                                        20-hydroxyecdysone 11
                                        24-epi-brassinolide 0
                                        25-deoxyecdysone 0
                                        26-hydroxybrassinolide 0
                                        26-hydroxycastasterone 0
                                        3-dehydro-6-deoxoteasterone 0
                                        3-epi-6-deoxocathasterone 0
                                        6-deoxocastasterone 0
                                        6-deoxoteasterone 0
                                        6-deoxotyphasterol 0
                                        6-deoxycathasterone 0
                                        brassinolide + 16
                                        brassinolide 23-O-alpha-D-glucoside 0
                                        castasterone + 0
                                        castasterone 23-O-alpha-D-glucoside 0
                                        cathasterone + 0
                                        ecdysone + 11
                                        halosterol A 0
                                        halosterol B 0
                                        inokosterone 0
                                        makisterone B 0
                                        podecdysone B 0
                                        polypodine B 0
                                        ponasterone A 4
                                        teasterone + 0
                                        typhasterol + 0
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