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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] |
CTD |
PMID:26048653 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
Ecdysterone results in increased expression of BAX protein |
CTD |
PMID:33878320 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
affects expression |
ISO |
Ecdysterone affects the expression of BCL2 protein |
CTD |
PMID:33878320 |
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NCBI chr13:22,689,783...22,853,920
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G |
Casp3 |
caspase 3 |
increases activity increases cleavage |
ISO |
Ecdysterone results in increased activity of CASP3 protein Ecdysterone results in increased cleavage of CASP3 protein |
CTD |
PMID:29126784 PMID:33878320 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] |
CTD |
PMID:26048653 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] |
CTD |
PMID:26048653 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
decreases expression increases expression |
ISO |
Ecdysterone results in decreased expression of HSPA5 protein Ecdysterone results in increased expression of HSPA5 mRNA |
CTD |
PMID:29126784 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Mtor |
mechanistic target of rapamycin kinase |
affects expression |
ISO |
Ecdysterone affects the expression of MTOR protein |
CTD |
PMID:33878320 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases response to substance |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein] NFE2L2 results in increased susceptibility to Ecdysterone |
CTD |
PMID:26048653 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
Ecdysterone results in increased cleavage of PARP1 protein |
CTD |
PMID:33878320 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Sqstm1 |
sequestosome 1 |
affects expression |
ISO |
Ecdysterone affects the expression of SQSTM1 protein |
CTD |
PMID:33878320 |
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NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
brassinolide results in decreased expression of BCL2 protein |
CTD |
PMID:17557751 PMID:20833159 |
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NCBI chr13:22,689,783...22,853,920
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
brassinolide results in decreased expression of BCL2L1 protein |
CTD |
PMID:20833159 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bid |
BH3 interacting domain death agonist |
decreases expression |
ISO |
brassinolide results in decreased expression of BID protein |
CTD |
PMID:20833159 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Casp3 |
caspase 3 |
increases activity increases expression |
ISO |
brassinolide results in increased activity of CASP3 protein brassinolide results in increased expression of CASP3 protein modified form |
CTD |
PMID:17557751 PMID:20833159 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
brassinolide results in decreased expression of CCNB1 protein |
CTD |
PMID:20833159 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
brassinolide results in decreased expression of CCND1 protein |
CTD |
PMID:20833159 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
brassinolide results in decreased expression of CCNE1 protein |
CTD |
PMID:20833159 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
brassinolide results in decreased expression of CDK2 protein |
CTD |
PMID:20833159 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
brassinolide results in decreased expression of CDK4 protein |
CTD |
PMID:20833159 |
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NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
brassinolide results in increased expression of CDKN1A protein |
CTD |
PMID:20833159 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
decreases expression |
ISO |
brassinolide results in decreased expression of CDKN1B protein |
CTD |
PMID:20833159 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Esr1 |
estrogen receptor 1 |
decreases expression |
ISO |
brassinolide results in decreased expression of ESR1 |
CTD |
PMID:20833159 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
affects localization decreases expression |
ISO |
brassinolide affects the localization of ESR2 protein brassinolide results in decreased expression of ESR2 |
CTD |
PMID:20833159 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Mdm2 |
MDM2 proto-oncogene |
decreases expression |
ISO |
brassinolide results in decreased expression of MDM2 protein |
CTD |
PMID:20833159 |
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NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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G |
Rb1 |
RB transcriptional corepressor 1 |
decreases expression |
ISO |
brassinolide results in decreased expression of RB1 protein; brassinolide results in decreased expression of RB1 protein modified form |
CTD |
PMID:20833159 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
brassinolide results in increased expression of TP53 protein |
CTD |
PMID:20833159 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Casp3 |
caspase 3 |
decreases activity multiple interactions |
EXP |
ponasterone A results in decreased activity of CASP3 protein L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein] |
CTD |
PMID:16396944 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Fhit |
fragile histidine triad diadenosine triphosphatase |
affects expression |
ISO |
ponasterone A affects the expression of FHIT protein |
CTD |
PMID:17019711 |
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NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
EXP |
L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein] |
CTD |
PMID:16396944 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases expression |
ISO |
ponasterone A results in increased expression of UGT1A3 protein |
CTD |
PMID:17058234 |
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NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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