Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:14alpha-hydroxy steroid
go back to main search page
Accession:CHEBI:36861 term browser browse the term
Synonyms:related_synonym: 14alpha-hydroxy steroids


show annotations for term's descendants           Sort by:
 
20-hydroxyecdysone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] CTD PMID:26048653 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G CASP3 caspase 3 increases activity EXP Ecdysterone results in increased activity of CASP3 protein CTD PMID:29126784 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] CTD PMID:26048653 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:26048653 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression
decreases expression
EXP Ecdysterone results in increased expression of HSPA5 mRNA
Ecdysterone results in decreased expression of HSPA5 protein
CTD PMID:29126784 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions
increases response to substance
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone
CTD PMID:26048653 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
ponasterone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases activity
multiple interactions
ISO ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]
CTD PMID:16396944 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase affects expression EXP ponasterone A affects the expression of FHIT protein CTD PMID:17019711 NCBI chr 3:59,747,277...61,251,452
Ensembl chr 3:59,747,277...61,251,459
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein] CTD PMID:16396944 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases expression EXP ponasterone A results in increased expression of UGT1A3 protein CTD PMID:17058234 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24815
    chemical entity 24785
      molecular entity 24749
        polyatomic entity 24681
          heteroatomic molecular entity 24294
            hydroxides 22930
              organic hydroxy compound 20775
                hydroxy steroid 13235
                  14-hydroxy steroid 264
                    14alpha-hydroxy steroid 9
                      2,22,25-trideoxyecdysone 0
                      2-deoxyecdysone 0
                      20-hydroxyecdysone 6
                      25-deoxyecdysone 0
                      ajugalactone 0
                      cyasterone 0
                      ecdysone + 6
                      inokosterone 0
                      makisterone B 0
                      polypodine B 0
                      ponasterone A 4
                      poststerone 0
                      shidasterone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24815
    subatomic particle 24774
      composite particle 24774
        hadron 24774
          baryon 24774
            nucleon 24774
              atomic nucleus 24774
                atom 24774
                  main group element atom 24641
                    p-block element atom 24641
                      carbon group element atom 24436
                        carbon atom 24401
                          organic molecular entity 24401
                            organic molecule 24287
                              organic cyclic compound 23556
                                organic polycyclic compound 17740
                                  steroid 13712
                                    hydroxy steroid 13235
                                      14-hydroxy steroid 264
                                        14alpha-hydroxy steroid 9
                                          2,22,25-trideoxyecdysone 0
                                          2-deoxyecdysone 0
                                          20-hydroxyecdysone 6
                                          25-deoxyecdysone 0
                                          ajugalactone 0
                                          cyasterone 0
                                          ecdysone + 6
                                          inokosterone 0
                                          makisterone B 0
                                          polypodine B 0
                                          ponasterone A 4
                                          poststerone 0
                                          shidasterone 0
paths to the root