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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:14alpha-hydroxy steroid
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Accession:CHEBI:36861 term browser browse the term
Synonyms:related_synonym: 14alpha-hydroxy steroids


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20-hydroxyecdysone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] CTD PMID:26048653 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Ecdysterone results in increased expression of BAX protein CTD PMID:33878320 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator affects expression EXP Ecdysterone affects the expression of BCL2 protein CTD PMID:33878320 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP3 caspase 3 increases activity
increases cleavage		 EXP Ecdysterone results in increased activity of CASP3 protein
Ecdysterone results in increased cleavage of CASP3 protein		 CTD PMID:29126784 PMID:33878320 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] CTD PMID:26048653 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:26048653 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression
decreases expression		 EXP Ecdysterone results in increased expression of HSPA5 mRNA
Ecdysterone results in decreased expression of HSPA5 protein		 CTD PMID:29126784 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G MTOR mechanistic target of rapamycin kinase affects expression EXP Ecdysterone affects the expression of MTOR protein CTD PMID:33878320 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
increases response to substance		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone		 CTD PMID:26048653 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP Ecdysterone results in increased cleavage of PARP1 protein CTD PMID:33878320 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G SQSTM1 sequestosome 1 affects expression EXP Ecdysterone affects the expression of SQSTM1 protein CTD PMID:33878320 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
ponasterone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases activity
multiple interactions		 ISO ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]		 CTD PMID:16396944 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G DNM1L dynamin 1 like multiple interactions ISO [ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of DNM1L protein CTD PMID:20164189 NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650 		JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase affects expression EXP ponasterone A affects the expression of FHIT protein CTD PMID:17019711 NCBI chr 3:59,747,277...61,251,452
Ensembl chr 3:59,747,277...61,251,459 		JBrowse link
G FIS1 fission, mitochondrial 1 multiple interactions ISO [ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein] CTD PMID:20164189 NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316 		JBrowse link
G MFN2 mitofusin 2 increases expression ISO [ponasterone A results in increased expression of PINK1 protein] which results in increased expression of MFN2 protein CTD PMID:20164189 NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211 		JBrowse link
G PINK1 PTEN induced kinase 1 increases expression
multiple interactions		 ISO [ponasterone A results in increased expression of PINK1 protein] which results in increased expression of MFN2 protein; ponasterone A results in increased expression of PINK1 protein
[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of DNM1L protein; [ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein]		 CTD PMID:20164189 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein] CTD PMID:16396944 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases expression EXP ponasterone A results in increased expression of UGT1A3 protein CTD PMID:17058234 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    chemical entity 26020
      molecular entity 25998
        polyatomic entity 25883
          heteroatomic molecular entity 25534
            hydroxides 24056
              organic hydroxy compound 22071
                hydroxy steroid 15543
                  14-hydroxy steroid 277
                    14alpha-hydroxy steroid 18
                      2,22,25-trideoxyecdysone 0
                      2-deoxyecdysone 0
                      20-hydroxyecdysone 11
                      25-deoxyecdysone 0
                      ajugalactone 0
                      cyasterone 0
                      ecdysone + 11
                      inokosterone 0
                      makisterone B 0
                      polypodine B 0
                      ponasterone A 8
                      poststerone 0
                      shidasterone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24281
                                organic polycyclic compound 18804
                                  steroid 15866
                                    hydroxy steroid 15543
                                      14-hydroxy steroid 277
                                        14alpha-hydroxy steroid 18
                                          2,22,25-trideoxyecdysone 0
                                          2-deoxyecdysone 0
                                          20-hydroxyecdysone 11
                                          25-deoxyecdysone 0
                                          ajugalactone 0
                                          cyasterone 0
                                          ecdysone + 11
                                          inokosterone 0
                                          makisterone B 0
                                          polypodine B 0
                                          ponasterone A 8
                                          poststerone 0
                                          shidasterone 0
paths to the root