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G |
AKT1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] |
CTD |
PMID:26048653 |
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NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
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G |
BAX |
BCL2 associated X, apoptosis regulator |
increases expression |
EXP |
Ecdysterone results in increased expression of BAX protein |
CTD |
PMID:33878320 |
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NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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G |
BCL2 |
BCL2 apoptosis regulator |
affects expression |
EXP |
Ecdysterone affects the expression of BCL2 protein |
CTD |
PMID:33878320 |
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NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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G |
CASP3 |
caspase 3 |
increases activity increases cleavage |
EXP |
Ecdysterone results in increased activity of CASP3 protein Ecdysterone results in increased cleavage of CASP3 protein |
CTD |
PMID:29126784 PMID:33878320 |
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
GSK3B |
glycogen synthase kinase 3 beta |
multiple interactions |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] |
CTD |
PMID:26048653 |
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NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
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G |
HMOX1 |
heme oxygenase 1 |
multiple interactions |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] |
CTD |
PMID:26048653 |
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NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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G |
HSPA5 |
heat shock protein family A (Hsp70) member 5 |
increases expression decreases expression |
EXP |
Ecdysterone results in increased expression of HSPA5 mRNA Ecdysterone results in decreased expression of HSPA5 protein |
CTD |
PMID:29126784 |
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NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
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G |
MTOR |
mechanistic target of rapamycin kinase |
affects expression |
EXP |
Ecdysterone affects the expression of MTOR protein |
CTD |
PMID:33878320 |
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NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
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G |
NFE2L2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases response to substance |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein] NFE2L2 results in increased susceptibility to Ecdysterone |
CTD |
PMID:26048653 |
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NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
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G |
PARP1 |
poly(ADP-ribose) polymerase 1 |
increases cleavage |
EXP |
Ecdysterone results in increased cleavage of PARP1 protein |
CTD |
PMID:33878320 |
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NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
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G |
SQSTM1 |
sequestosome 1 |
affects expression |
EXP |
Ecdysterone affects the expression of SQSTM1 protein |
CTD |
PMID:33878320 |
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NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
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G |
CASP3 |
caspase 3 |
decreases activity multiple interactions |
ISO |
ponasterone A results in decreased activity of CASP3 protein L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein] |
CTD |
PMID:16396944 |
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
DNM1L |
dynamin 1 like |
multiple interactions |
ISO |
[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of DNM1L protein |
CTD |
PMID:20164189 |
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NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650
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G |
FHIT |
fragile histidine triad diadenosine triphosphatase |
affects expression |
EXP |
ponasterone A affects the expression of FHIT protein |
CTD |
PMID:17019711 |
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NCBI chr 3:59,747,277...61,251,452
Ensembl chr 3:59,747,277...61,251,459
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G |
FIS1 |
fission, mitochondrial 1 |
multiple interactions |
ISO |
[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein] |
CTD |
PMID:20164189 |
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NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316
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G |
MFN2 |
mitofusin 2 |
increases expression |
ISO |
[ponasterone A results in increased expression of PINK1 protein] which results in increased expression of MFN2 protein |
CTD |
PMID:20164189 |
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NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211
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G |
PINK1 |
PTEN induced kinase 1 |
increases expression multiple interactions |
ISO |
[ponasterone A results in increased expression of PINK1 protein] which results in increased expression of MFN2 protein; ponasterone A results in increased expression of PINK1 protein [ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of DNM1L protein; [ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein] |
CTD |
PMID:20164189 |
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NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO |
L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein] |
CTD |
PMID:16396944 |
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NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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G |
UGT1A3 |
UDP glucuronosyltransferase family 1 member A3 |
increases expression |
EXP |
ponasterone A results in increased expression of UGT1A3 protein |
CTD |
PMID:17058234 |
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NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300
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