14-hydroxy steroid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	14-hydroxy steroid	go back to main search page
Accession:	CHEBI:36860	browse the term
Synonyms:	related_synonym:	14-hydroxy steroids

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Rat (275) Mouse (275) Human (277) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (2) Green Monkey (0) Naked Mole-rat (0) All
Genes (277)

20-hydroxyecdysone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

BCL2 associated X, apoptosis regulator

increases expression

Ecdysterone results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

affects expression

Ecdysterone affects the expression of BCL2 protein

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

caspase 3

increases activity
increases cleavage

Ecdysterone results in increased activity of CASP3 protein
Ecdysterone results in increased cleavage of CASP3 protein

PMID:29126784 PMID:33878320

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

glycogen synthase kinase 3 beta

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

heme oxygenase 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

heat shock protein family A (Hsp70) member 5

increases expression
decreases expression

Ecdysterone results in increased expression of HSPA5 mRNA
Ecdysterone results in decreased expression of HSPA5 protein

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

mechanistic target of rapamycin kinase

affects expression

Ecdysterone affects the expression of MTOR protein

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases response to substance

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

poly(ADP-ribose) polymerase 1

increases cleavage

Ecdysterone results in increased cleavage of PARP1 protein

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

sequestosome 1

affects expression

Ecdysterone affects the expression of SQSTM1 protein

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

bufalin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

multiple interactions

bufalin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

actin beta

increases expression

bufalin results in increased expression of ACTB protein

NCBI chr 7:5,527,148...5,530,601
Ensembl chr 7:5,526,409...5,563,902

G

actin gamma 1

increases expression

bufalin results in increased expression of ACTG1 protein

NCBI chr17:81,509,971...81,512,799
Ensembl chr17:81,509,413...81,523,847

G

AKT serine/threonine kinase 1

multiple interactions

bufalin results in increased phosphorylation of and results in decreased expression of AKT1 protein

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

apoptotic peptidase activating factor 1

increases expression

bufalin results in increased expression of APAF1 protein

NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,290...98,735,433

G

BCL2 apoptosis regulator

decreases expression

bufalin results in decreased expression of BCL2 mRNA; bufalin results in decreased expression of BCL2 protein

PMID:7658701 PMID:27444971

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

caspase 3

increases expression

bufalin results in increased expression of CASP3 mRNA; bufalin results in increased expression of CASP3 protein modified form

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 9

increases activity

bufalin results in increased activity of CASP9 protein

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

COPI coat complex subunit epsilon

decreases expression

bufalin results in decreased expression of COPE protein

NCBI chr19:18,899,514...18,919,387
Ensembl chr19:18,899,514...18,919,387

G

cytochrome c, somatic

multiple interactions
increases expression

bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]; HSPB1 protein inhibits the reaction [bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]]
bufalin results in increased expression of CYCS protein

PMID:23091618 PMID:27444971

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

cytochrome P450 family 3 subfamily A member 4

multiple interactions
increases expression
increases metabolic processing

bufalin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; bufalin results in increased expression of and results in increased activity of CYP3A4 protein; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufalin]
bufalin results in increased expression of CYP3A4 mRNA

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

DNA damage inducible transcript 3

increases expression

bufalin results in increased expression of DDIT3 mRNA

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

bufalin results in increased expression of DNAJB11 protein

NCBI chr 3:186,570,720...186,585,793
Ensembl chr 3:186,567,403...186,585,800

G

deoxyuridine triphosphatase

decreases expression

bufalin results in decreased expression of DUT protein

NCBI chr15:48,331,095...48,343,373
Ensembl chr15:48,331,011...48,343,373

G

eukaryotic translation initiation factor 2 alpha kinase 3

decreases phosphorylation

bufalin results in decreased phosphorylation of EIF2AK3 protein

NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518

G

endonuclease G

increases expression

bufalin results in increased expression of ENDOG mRNA; bufalin results in increased expression of ENDOG protein

NCBI chr 9:128,818,500...128,822,676
Ensembl chr 9:128,818,500...128,822,676

G

enolase 1

decreases expression

bufalin results in decreased expression of ENO1 protein

NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190

G

Fas cell surface death receptor

increases expression

bufalin results in increased expression of FAS protein

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fas ligand

increases expression

bufalin results in increased expression of FASLG protein

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased expression of FOS mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bufalin results in increased expression of FOS mRNA]

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

G

growth factor receptor bound protein 2

decreases expression

bufalin results in decreased expression of GRB2 protein

NCBI chr17:75,318,076...75,405,678
Ensembl chr17:75,318,076...75,405,709

G

glutathione S-transferase pi 1

decreases expression

bufalin results in decreased expression of GSTP1 protein

NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656

G

heterogeneous nuclear ribonucleoprotein H1

decreases expression

bufalin results in decreased expression of HNRNPH1 protein

NCBI chr 5:179,614,178...179,634,784
Ensembl chr 5:179,614,178...179,634,784

G

heterogeneous nuclear ribonucleoprotein K

decreases expression

bufalin results in decreased expression of HNRNPK protein

NCBI chr 9:83,968,083...83,980,615
Ensembl chr 9:83,968,083...83,980,631

G

heat shock protein family A (Hsp70) member 5

decreases expression

bufalin results in decreased expression of HSPA5 mRNA

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

heat shock protein family B (small) member 1

multiple interactions
decreases response to substance
decreases expression

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [bufalin results in decreased expression of HSPB1 protein]; bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]; HSPB1 protein inhibits the reaction [bufalin affects the localization of RELA protein]; HSPB1 protein inhibits the reaction [bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]]; HSPB1 protein inhibits the reaction [bufalin results in increased cleavage of PARP1 protein]
HSPB1 protein results in decreased susceptibility to bufalin

NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295

G

interleukin 1 beta

multiple interactions
increases expression

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; Ro 31-8220 inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; SB 203580 promotes the reaction [bufalin results in increased expression of IL1B mRNA]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases phosphorylation

bufalin results in decreased phosphorylation of JUN protein

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

keratin 18

increases expression

bufalin results in increased expression of KRT18 protein

NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906

G

mitogen-activated protein kinase kinase 7

decreases expression

bufalin results in decreased expression of MAP2K7 protein

NCBI chr19:7,903,877...7,914,478
Ensembl chr19:7,903,843...7,914,478

G

mitogen-activated protein kinase kinase kinase 3

decreases expression

bufalin results in decreased expression of MAP3K3 protein

NCBI chr17:63,622,417...63,696,305
Ensembl chr17:63,622,415...63,696,305

G

mitogen-activated protein kinase 1

multiple interactions
decreases activity
increases phosphorylation

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]; Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [bufalin results in increased phosphorylation of MAPK1 protein]
bufalin results in decreased activity of MAPK1 protein

PMID:10712238 PMID:21922632

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions
decreases activity
increases phosphorylation

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased phosphorylation of MAPK3 protein]; Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [bufalin results in increased phosphorylation of MAPK3 protein]
bufalin results in decreased activity of MAPK3 protein

PMID:10712238 PMID:21922632

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

decreases activity

bufalin results in decreased activity of MAPK8 protein

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 9

decreases activity

bufalin results in decreased activity of MAPK9 protein

NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

bufalin co-treated with osimertinib decreases expression of MCL1 protein in lung
Bufalin decreases expression of MCL1 protein in lung

RGD

PMID:31301315 PMID:28419994

RGD:151356917, RGD:151356918

NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738

G

matrix metallopeptidase 1

decreases expression

bufalin results in decreased expression of MMP1 protein

NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160

G

matrix metallopeptidase 2

multiple interactions
decreases secretion
decreases expression

bufalin results in decreased expression of and results in decreased activity of MMP2 protein
bufalin results in decreased secretion of MMP2 protein
bufalin results in decreased expression of MMP2 mRNA

PMID:21922632 PMID:23949904

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 9

decreases activity
decreases secretion
multiple interactions
decreases expression

bufalin results in decreased activity of MMP9 protein
bufalin results in decreased secretion of MMP9 protein
bufalin results in decreased expression of and results in decreased activity of MMP9 protein
bufalin results in decreased expression of MMP9 mRNA

PMID:21922632 PMID:23949904

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

bufalin results in decreased expression of MYC mRNA

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

nitric oxide synthase 2

decreases expression

bufalin results in decreased expression of NOS2 protein

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

poly(ADP-ribose) polymerase 1

increases cleavage
multiple interactions

bufalin results in increased cleavage of PARP1 protein
HSPB1 protein inhibits the reaction [bufalin results in increased cleavage of PARP1 protein]

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

inorganic pyrophosphatase 1

decreases expression

bufalin results in decreased expression of PPA1 protein

NCBI chr10:70,202,835...70,233,429
Ensembl chr10:70,202,835...70,233,911

G

protein phosphatase 2 catalytic subunit beta

decreases expression

bufalin results in decreased expression of PPP2CB protein

NCBI chr 8:30,785,616...30,812,818
Ensembl chr 8:30,774,457...30,814,314

G

proteasome 20S subunit alpha 3

decreases expression

bufalin results in decreased expression of PSMA3 protein

NCBI chr14:58,244,843...58,272,004
Ensembl chr14:58,244,843...58,272,012

G

prostaglandin-endoperoxide synthase 2

decreases expression

bufalin results in decreased expression of PTGS2 protein

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

protein tyrosine kinase 2

decreases expression

bufalin results in decreased expression of PTK2 protein

NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216

G

RELA proto-oncogene, NF-kB subunit

decreases expression
multiple interactions
affects localization

bufalin results in decreased expression of RELA protein
HSPB1 protein inhibits the reaction [bufalin affects the localization of RELA protein]

PMID:23091618 PMID:23949904

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

ras homolog family member A

decreases expression

bufalin results in decreased expression of RHOA protein

NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998

G

Rho associated coiled-coil containing protein kinase 1

decreases expression

bufalin results in decreased expression of ROCK1 protein

NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,944,612...21,111,813

G

ribosomal protein lateral stalk subunit P0

decreases expression

bufalin results in decreased expression of RPLP0 protein

NCBI chr12:120,196,699...120,201,111
Ensembl chr12:120,196,699...120,201,235

G

ribosomal protein SA

increases expression

bufalin results in increased expression of RPSA protein

NCBI chr 3:39,406,720...39,412,542
Ensembl chr 3:39,406,716...39,426,255

G

SAP domain containing ribonucleoprotein

increases expression

bufalin results in increased expression of SARNP protein

NCBI chr12:55,752,463...55,817,724
Ensembl chr12:55,752,463...55,817,724

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

bufalin results in decreased expression of SOS1 protein

NCBI chr 2:38,981,549...39,124,868
Ensembl chr 2:38,962,206...39,124,345

G

TAR DNA binding protein

decreases expression

bufalin results in decreased expression of TARDBP protein

NCBI chr 1:11,012,654...11,030,528
Ensembl chr 1:11,012,344...11,030,528

G

t-complex 1

decreases expression

bufalin results in decreased expression of TCP1 protein

NCBI chr 6:159,778,498...159,789,602
Ensembl chr 6:159,778,498...159,789,703

G

tropomodulin 3

decreases expression

bufalin results in decreased expression of TMOD3 protein

NCBI chr15:51,829,653...51,915,725
Ensembl chr15:51,829,628...51,947,295

G

tumor necrosis factor

increases expression
multiple interactions

bufalin results in increased expression of TNF mRNA
SB 203580 promotes the reaction [bufalin results in increased expression of TNF mRNA]

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

triosephosphate isomerase 1

decreases expression

bufalin results in decreased expression of TPI1 protein

NCBI chr12:6,867,420...6,870,948
Ensembl chr12:6,867,119...6,870,948

G

tumor protein, translationally-controlled 1

decreases expression

bufalin results in decreased expression of TPT1 protein

NCBI chr13:45,333,471...45,341,183
Ensembl chr13:45,333,471...45,341,284

G

vascular endothelial growth factor A

decreases expression

bufalin results in decreased expression of VEGFA protein

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

digitoxigenin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

decreases expression

Digitoxigenin results in decreased expression of CCL2 protein

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

C-C motif chemokine ligand 4

decreases expression

Digitoxigenin results in decreased expression of CCL4 protein

NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621

G

C-C motif chemokine ligand 5

decreases expression

Digitoxigenin results in decreased expression of CCL5 protein

NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793

G

C-X-C motif chemokine ligand 8

decreases expression

Digitoxigenin results in decreased expression of CXCL8 protein

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

interleukin 6 receptor

decreases expression

Digitoxigenin results in decreased expression of IL6R protein modified form

NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450

G

vascular endothelial growth factor A

decreases expression

Digitoxigenin results in decreased expression of VEGFA protein

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

digitoxin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

multiple interactions
increases transport

Digitoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
ABCB1 protein results in increased transport of Digitoxin

PMID:23104431 PMID:26708294

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

androgen receptor

multiple interactions

Digitoxin binds to and results in decreased activity of AR protein

NCBI chr X:67,544,021...67,730,619
Ensembl chr X:67,544,021...67,730,619

G

baculoviral IAP repeat containing 5

decreases expression

Digitoxin analog results in decreased expression of BIRC5 protein; Digitoxin results in decreased expression of BIRC5 protein

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

caspase 3

decreases expression
multiple interactions

Digitoxin analog results in decreased expression of CASP3 protein; Digitoxin results in decreased expression of CASP3 protein
Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]]

PMID:22037315 PMID:34717917

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

increases cleavage
multiple interactions

Digitoxin analog results in increased cleavage of CASP8 protein; Digitoxin results in increased cleavage of CASP8 protein
Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]

PMID:22037315 PMID:34717917

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

increases cleavage

Digitoxin analog results in increased cleavage of CASP9 protein; Digitoxin results in increased cleavage of CASP9 protein

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

C-C motif chemokine ligand 2

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

cyclin B1

multiple interactions
decreases expression

Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]
Digitoxin analog results in decreased expression of CCNB1 protein; Digitoxin results in decreased expression of CCNB1 protein

NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245

G

cyclin D1

multiple interactions
decreases expression

Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]; Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]]
Digitoxin results in decreased expression of CCND1 protein

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cyclin dependent kinase 1

decreases expression
multiple interactions

Digitoxin analog results in decreased expression of CDK1 protein; Digitoxin results in decreased expression of CDK1 protein
Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

cyclin dependent kinase inhibitor 1A

decreases expression

Digitoxin analog results in decreased expression of CDKN1A protein; Digitoxin results in decreased expression of CDKN1A protein

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337

G

cyclin dependent kinase inhibitor 1B

decreases expression

Digitoxin analog results in decreased expression of CDKN1B protein; Digitoxin results in decreased expression of CDKN1B protein

NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369

G

checkpoint kinase 1

decreases expression

Digitoxin analog results in decreased expression of CHEK1 protein; Digitoxin results in decreased expression of CHEK1 protein

NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255

G

checkpoint kinase 2

decreases expression

Digitoxin analog results in decreased expression of CHEK2 protein; Digitoxin results in decreased expression of CHEK2 protein

NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422

G

C-X-C motif chemokine ligand 8

decreases secretion

Digitoxin results in decreased secretion of CXCL8 protein

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

cytochrome c, somatic

increases expression

Digitoxin analog results in increased expression of CYCS protein; Digitoxin results in increased expression of CYCS protein

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
decreases phosphorylation

Digitoxin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of EIF4EBP1 protein]
Digitoxin results in decreased phosphorylation of EIF4EBP1 protein

NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365

G

estrogen receptor 1

multiple interactions

Digitoxin binds to and results in decreased activity of ESR1 protein

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

estrogen receptor 2

multiple interactions

Digitoxin binds to and results in decreased activity of ESR2 protein

NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112

G

FA complementation group D2

multiple interactions

Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]

NCBI chr 3:10,026,437...10,101,932
Ensembl chr 3:10,026,370...10,101,932

G

FA complementation group I

multiple interactions

Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]

NCBI chr15:89,243,979...89,317,259
Ensembl chr15:89,243,945...89,317,261

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]; Digitoxin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Digitoxin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]]

NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259

G

interleukin 1 beta

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

mitogen-activated protein kinase 1

multiple interactions

Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions

Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

nuclear factor kappa B subunit 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NFKB inhibitor alpha

decreases phosphorylation

Digitoxin results in decreased phosphorylation of NFKBIA protein

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

nitric oxide synthase 3

multiple interactions
increases activity

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin results in increased activity of NOS3 protein]; Calcium deficiency inhibits the reaction [Digitoxin results in increased activity of NOS3 protein]

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

G

progesterone receptor

multiple interactions

Digitoxin binds to and results in decreased activity of PGR protein

NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813

G

protein inhibitor of activated STAT 3

increases expression

Digitoxin results in increased expression of PIAS3 protein

NCBI chr 1:145,848,522...145,859,081
Ensembl chr 1:145,848,522...145,859,836

G

phosphatase and tensin homolog

increases expression

Digitoxin results in increased expression of PTEN protein

NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930

G

protein tyrosine phosphatase non-receptor type 6

increases expression

Digitoxin results in increased expression of PTPN6 protein

NCBI chr12:6,946,577...6,961,316
Ensembl chr12:6,946,468...6,961,316

G

ribosomal protein S6 kinase B1

decreases phosphorylation
multiple interactions

Digitoxin results in decreased phosphorylation of RPS6KB1 protein
[Digitoxin co-treated with Oxygen deficiency] results in decreased phosphorylation of RPS6KB1 protein

NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574

G

signal transducer and activator of transcription 3

multiple interactions

[Digitoxin co-treated with Oxygen deficiency] results in decreased expression of and results in decreased phosphorylation of STAT3 protein; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]; Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]; Digitoxin results in decreased expression of and results in decreased phosphorylation of STAT3 protein; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]]

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

thyroid hormone receptor alpha

multiple interactions

Digitoxin binds to and results in decreased activity of THRA protein

NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867

G

thyroid hormone receptor beta

multiple interactions

Digitoxin binds to and results in decreased activity of THRB protein

NCBI chr 3:24,117,153...24,495,708
Ensembl chr 3:24,117,153...24,495,756

G

tumor protein p53

decreases expression

Digitoxin analog results in decreased expression of TP53 protein; Digitoxin results in decreased expression of TP53 protein

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

vascular cell adhesion molecule 1

multiple interactions

Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]

NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045

digoxigenin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

increases transport

ABCB1 protein results in increased transport of Digoxigenin

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

C-C motif chemokine ligand 2

decreases expression

Digoxigenin results in decreased expression of CCL2 protein

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

C-C motif chemokine ligand 4

decreases expression

Digoxigenin results in decreased expression of CCL4 protein

NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621

G

C-X-C motif chemokine ligand 8

decreases expression

Digoxigenin results in decreased expression of CXCL8 protein

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions
increases expression

Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter]
Digoxigenin results in increased expression of G6PC1 mRNA

NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438

G

interleukin 17A

multiple interactions

Digoxigenin results in increased expression of and results in increased secretion of IL17A protein

NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638

G

interleukin 17F

multiple interactions

Digoxigenin results in increased expression of and results in increased secretion of IL17F protein

NCBI chr 6:52,236,681...52,245,689
Ensembl chr 6:52,236,681...52,245,689

G

interleukin 6 receptor

decreases expression

Digoxigenin results in decreased expression of IL6R protein modified form

NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450

G

neuronal PAS domain protein 2

multiple interactions
increases expression

Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]
Digoxigenin results in increased expression of NPAS2 mRNA

NCBI chr 2:100,818,723...100,996,829
Ensembl chr 2:100,820,139...100,996,829

G

RAR related orphan receptor C

multiple interactions
increases expression

Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter]; Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [Digoxigenin results in increased expression of RORC mRNA]

NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845

G

vascular endothelial growth factor A

decreases expression

Digoxigenin results in decreased expression of VEGFA protein

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

dihydroouabain

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glucose-6-phosphatase catalytic subunit 1

increases expression
multiple interactions

dihydroouabain results in increased expression of G6PC1 mRNA
dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]

NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438

G

interleukin 17A

multiple interactions

dihydroouabain results in increased expression of and results in increased secretion of IL17A protein

NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638

G

interleukin 17F

multiple interactions

dihydroouabain results in increased expression of and results in increased secretion of IL17F protein

NCBI chr 6:52,236,681...52,245,689
Ensembl chr 6:52,236,681...52,245,689

G

neuronal PAS domain protein 2

multiple interactions
increases expression

dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]
dihydroouabain results in increased expression of NPAS2 mRNA

NCBI chr 2:100,818,723...100,996,829
Ensembl chr 2:100,820,139...100,996,829

G

RAR related orphan receptor C

multiple interactions
increases expression

dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]; dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [dihydroouabain results in increased expression of RORC mRNA]

NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845

hellebrigenin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

hellebrigenin results in decreased phosphorylation of and results in decreased expression of AKT1 protein

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

ATM serine/threonine kinase

increases phosphorylation

hellebrigenin results in increased phosphorylation of ATM protein

NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102

G

BCL2 associated X, apoptosis regulator

affects localization

hellebrigenin affects the localization of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

cyclin B1

increases expression

hellebrigenin results in increased expression of CCNB1 protein

NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245

G

cell division cycle 25C

decreases phosphorylation

hellebrigenin results in decreased phosphorylation of CDC25C protein

NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355

G

cyclin dependent kinase 1

increases phosphorylation

hellebrigenin results in increased phosphorylation of CDK1 protein

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

checkpoint kinase 2

increases phosphorylation

hellebrigenin results in increased phosphorylation of CHEK2 protein

NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422

G

poly(ADP-ribose) polymerase 1

increases activity

hellebrigenin results in increased activity of PARP1 protein

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

helveticoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RAR related orphan receptor C

increases expression

helveticoside results in increased expression of RORC mRNA

NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845

oleandrin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity

oleandrin results in increased activity of CASP3 protein

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

increases activity

oleandrin results in increased activity of CASP8 protein

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

C-X-C motif chemokine receptor 1

increases expression

oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein

NCBI chr 2:218,162,841...218,166,962
Ensembl chr 2:218,162,841...218,166,962

G

C-X-C motif chemokine receptor 2

increases expression

oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein

NCBI chr 2:218,125,294...218,137,251
Ensembl chr 2:218,125,289...218,137,251

G

C-X-C motif chemokine receptor 4

increases expression

oleandrin results in increased expression of CXCR4 mRNA

NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177

ouabain

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

affects expression

Ouabain affects the expression of A2M protein

NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229

G

ATP binding cassette subfamily B member 1

multiple interactions
increases expression

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; [Ouabain results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]
Ouabain results in increased expression of ABCB1 mRNA; Ouabain results in increased expression of ABCB1 protein

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

acetyl-CoA acyltransferase 2

affects expression

Ouabain affects the expression of ACAA2 protein

NCBI chr18:49,782,164...49,813,533
Ensembl chr18:49,782,164...49,813,953

G

angiotensin I converting enzyme

affects expression

Ouabain affects the expression of ACE mRNA; Ouabain affects the expression of ACE protein

NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380

G

actin alpha 2, smooth muscle

affects expression

Ouabain affects the expression of ACTA2 protein

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

affects expression

Ouabain affects the expression of ADH1C protein

NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746

G

angiotensinogen

affects expression
increases expression

Ouabain affects the expression of AGT protein
Ouabain results in increased expression of AGT protein

PMID:11768735 PMID:16565308

NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576

G

angiotensin II receptor type 1

affects expression
decreases expression

Ouabain affects the expression of AGTR1A mRNA
Ouabain results in decreased expression of AGTR1A protein

NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008

G

apoptosis inducing factor mitochondria associated 1

increases expression

Ouabain results in increased expression of AIFM1 protein

NCBI chr X:130,129,362...130,165,841
Ensembl chr X:130,124,666...130,165,879

G

annexin A1

affects expression

Ouabain affects the expression of ANXA1 protein

NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393

G

annexin A2

affects expression

Ouabain affects the expression of ANXA2 protein

NCBI chr15:60,347,151...60,397,986
Ensembl chr15:60,347,134...60,402,883

G

apoptotic peptidase activating factor 1

increases expression

Ouabain results in increased expression of APAF1 protein

NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,290...98,735,433

G

A-Raf proto-oncogene, serine/threonine kinase

decreases expression

Ouabain results in decreased expression of ARAF mRNA

NCBI chr X:47,561,205...47,571,908
Ensembl chr X:47,561,205...47,571,908

G

ariadne RBR E3 ubiquitin protein ligase 1

decreases expression

Ouabain results in decreased expression of ARIH1 mRNA

NCBI chr15:72,474,330...72,602,987
Ensembl chr15:72,474,330...72,602,987

G

actin related protein 2/3 complex subunit 5

affects expression

Ouabain affects the expression of ARPC5 protein

NCBI chr 1:183,620,846...183,635,783
Ensembl chr 1:183,620,846...183,635,783

G

arrestin beta 1

increases expression

Ouabain results in increased expression of ARRB1 mRNA

NCBI chr11:75,260,122...75,351,661
Ensembl chr11:75,260,122...75,351,705

G

N-acylsphingosine amidohydrolase 1

affects expression

Ouabain affects the expression of ASAH1 protein

NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998

G

activating transcription factor 6 beta

increases expression

Ouabain results in increased expression of ATF6B protein

NCBI chr 6:32,115,264...32,128,246
Ensembl chr 6:32,115,264...32,128,253

G

ATM serine/threonine kinase

increases phosphorylation

Ouabain results in increased phosphorylation of ATM protein

NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102

G

ATPase H+/K+ transporting non-gastric alpha2 subunit

multiple interactions

Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium]

NCBI chr13:24,680,408...24,712,472
Ensembl chr13:24,680,408...24,712,472

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions
increases expression
affects expression
affects binding

Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA]; Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein]
Ouabain affects the expression of ATP1A1 protein
Ouabain results in increased expression of ATP1A1 mRNA; Ouabain results in increased expression of ATP1A1 protein
Ouabain binds to ATP1A1 protein

PMID:11768735 PMID:11834625 PMID:12479229 PMID:16716361 PMID:19995221

NCBI chr 1:116,373,244...116,404,774
Ensembl chr 1:116,372,668...116,410,261

G

ATPase Na+/K+ transporting subunit alpha 2

multiple interactions
increases expression
decreases expression
affects expression
decreases activity
affects response to substance
affects binding

Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA]
Ouabain results in increased expression of ATP1A2 protein
Ouabain results in decreased expression of ATP1A2 mRNA
Ouabain affects the expression of ATP1A2 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA]
Ouabain results in decreased activity of ATP1A2 protein
Ouabain binds to and results in decreased activity of ATP1A2 protein
ATP1A2 protein affects the susceptibility to Ouabain
Ouabain binds to ATP1A2 protein

PMID:11834625 PMID:12479229 PMID:15458945 PMID:16166162 PMID:16716361 More...

NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591

G

ATPase Na+/K+ transporting subunit alpha 3

increases expression
multiple interactions
decreases expression
affects expression
affects binding

Ouabain results in increased expression of ATP1A3 mRNA; Ouabain results in increased expression of ATP1A3 protein
Potassium Chloride inhibits the reaction [ATP1A3 protein binds to Ouabain]
Ouabain results in decreased expression of ATP1A3 mRNA
Ouabain affects the expression of ATP1A3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A3 mRNA]
ATP1A3 protein binds to Ouabain; Ouabain binds to ATP1A3 protein

PMID:11204457 PMID:12479229 PMID:15276875 PMID:19687166 PMID:19995221 More...

NCBI chr19:41,966,582...41,994,230
Ensembl chr19:41,966,582...41,997,497

G

ATPase Na+/K+ transporting subunit beta 1

multiple interactions
increases expression

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; Calcium affects the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; W 7 inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]

NCBI chr 1:169,106,690...169,132,719
Ensembl chr 1:169,105,697...169,310,992

G

ATPase H+/K+ transporting subunit beta

multiple interactions

Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium]

NCBI chr13:113,648,804...113,658,198
Ensembl chr13:113,648,804...113,658,198

G

ATP synthase F1 subunit alpha

affects expression

Ouabain affects the expression of ATP5F1A protein

NCBI chr18:46,080,248...46,104,227
Ensembl chr18:46,080,248...46,104,334

G

ATR serine/threonine kinase

decreases phosphorylation

Ouabain results in decreased phosphorylation of ATR protein

NCBI chr 3:142,449,235...142,578,733
Ensembl chr 3:142,449,007...142,578,733

G

bromo adjacent homology domain containing 1

decreases expression

Ouabain results in decreased expression of BAHD1 mRNA

NCBI chr15:40,437,452...40,468,236
Ensembl chr15:40,439,721...40,468,236

G

BCL2 associated X, apoptosis regulator

affects localization
increases expression
multiple interactions

Ouabain affects the localization of BAX protein
Ouabain results in increased expression of BAX protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]

PMID:17096883 PMID:18247327 PMID:31436044

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression

Ouabain results in decreased expression of BCL2 protein

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

decreases expression

Ouabain results in decreased expression of BCL2L1 protein

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

brain derived neurotrophic factor

multiple interactions
decreases expression

Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein]

NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058

G

BRCA1 DNA repair associated

decreases expression

Ouabain results in decreased expression of BRCA1 protein

NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245

G

calbindin 1

decreases expression

Ouabain results in decreased expression of CALB1 protein

NCBI chr 8:90,058,608...90,082,879
Ensembl chr 8:90,058,608...90,095,475

G

calmodulin like 5

affects expression

Ouabain affects the expression of CALML5 protein

NCBI chr10:5,498,697...5,499,570
Ensembl chr10:5,498,697...5,499,570

G

calcium/calmodulin dependent protein kinase II beta

increases expression

Ouabain results in increased expression of CAMK2B protein

NCBI chr 7:44,217,154...44,326,013
Ensembl chr 7:44,210,019...44,334,577

G

calnexin

increases expression

Ouabain results in increased expression of CANX protein

NCBI chr 5:179,678,656...179,731,641
Ensembl chr 5:179,678,628...179,731,641

G

caspase 3

increases expression
multiple interactions
increases activity

Ouabain results in increased expression of CASP3 protein
Ouabain results in increased activity of and results in increased cleavage of CASP3 protein
Ouabain results in increased activity of CASP3 protein

PMID:11435898 PMID:17096883 PMID:18247327 PMID:20435043 PMID:31436044

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 4

increases expression

Ouabain results in increased expression of CASP4 protein

NCBI chr11:104,942,866...104,968,574
Ensembl chr11:104,942,866...104,969,366

G

caspase 8

multiple interactions

Ouabain results in increased expression of and results in increased activity of CASP8 protein

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

multiple interactions

Ouabain results in increased expression of and results in increased activity of CASP9 protein

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

catalase

multiple interactions
decreases activity

Lithium inhibits the reaction [Ouabain results in decreased activity of CAT protein]; Valproic Acid inhibits the reaction [Ouabain results in decreased activity of CAT protein]

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

caveolin 1

decreases expression

Ouabain results in decreased expression of CAV1 mRNA

NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179

G

coiled-coil domain containing 14

decreases expression

Ouabain results in decreased expression of CCDC14 mRNA

NCBI chr 3:123,885,176...123,961,229
Ensembl chr 3:123,897,305...123,961,408

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 protein]
Ouabain results in increased expression of CCL2 mRNA; Ouabain results in increased expression of CCL2 protein

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

cyclin A1

decreases expression

Ouabain results in decreased expression of CCNA1 mRNA

NCBI chr13:36,431,517...36,442,870
Ensembl chr13:36,431,520...36,442,870

G

cyclin A2

decreases expression

Ouabain results in decreased expression of CCNA2 mRNA

NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883

G

cyclin D1

decreases expression

Ouabain results in decreased expression of CCND1 mRNA

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cadherin 1

increases expression
decreases expression

Ouabain results in increased expression of CDH1 mRNA
Ouabain results in decreased expression of CDH1 protein

NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537

G

cadherin 2

decreases expression

Ouabain results in decreased expression of CDH2 mRNA; Ouabain results in decreased expression of CDH2 protein

NCBI chr18:27,932,879...28,177,130
Ensembl chr18:27,932,879...28,177,946

G

cyclin dependent kinase 2

decreases expression

Ouabain results in decreased expression of CDK2 mRNA; Ouabain results in decreased expression of CDK2 protein

PMID:20460749 PMID:21215801 PMID:31436044

NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789

G

cyclin dependent kinase 6

decreases expression

Ouabain results in decreased expression of CDK6 protein

NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573

G

cyclin dependent kinase inhibitor 1A

decreases expression
increases expression

Ouabain results in decreased expression of CDKN1A mRNA; Ouabain results in decreased expression of CDKN1A protein
Ouabain results in increased expression of CDKN1A mRNA; Ouabain results in increased expression of CDKN1A protein

PMID:20460749 PMID:21215801 PMID:28795476 PMID:31436044

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337

G

creatine kinase B

decreases activity

Ouabain results in decreased activity of CKB protein

NCBI chr14:103,519,667...103,522,830
Ensembl chr14:103,519,667...103,522,833

G

claudin 1

decreases expression

Ouabain results in decreased expression of CLDN1 protein

NCBI chr 3:190,305,707...190,322,446
Ensembl chr 3:190,305,707...190,322,446

G

canopy FGF signaling regulator 2

affects expression

Ouabain affects the expression of CNPY2 protein

NCBI chr12:56,309,844...56,316,346
Ensembl chr12:56,309,842...56,316,119

G

collagen type I alpha 1 chain

increases expression
multiple interactions

Ouabain results in increased expression of COL1A1 mRNA
MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

G

citrate synthase

decreases activity

Ouabain results in decreased activity of CS protein

NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391

G

cytochrome c1

multiple interactions

Ouabain results in decreased expression of and affects the localization of CYC1 protein

NCBI chr 8:144,095,076...144,097,525
Ensembl chr 8:144,095,039...144,097,525

G

DNA damage inducible transcript 3

increases expression

Ouabain results in increased expression of DDIT3 protein

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

decreases expression

Ouabain results in decreased expression of DDOST mRNA

NCBI chr 1:20,651,777...20,661,369
Ensembl chr 1:20,651,767...20,661,544

G

DnaJ heat shock protein family (Hsp40) member A3

increases expression

Ouabain results in increased expression of DNAJA3 mRNA

NCBI chr16:4,425,868...4,456,775
Ensembl chr16:4,425,805...4,456,775

G

dopamine receptor D1

multiple interactions
decreases expression

Ouabain results in decreased expression of and results in increased phosphorylation of DRD1 protein
Ouabain results in increased phosphorylation of and results in decreased expression of DRD1 protein
Ouabain results in decreased expression of DRD1 mRNA

PMID:19626329 PMID:20132239

NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182

G

desmoglein 1

affects expression

Ouabain affects the expression of DSG1 protein

NCBI chr18:31,318,160...31,359,246
Ensembl chr18:31,318,160...31,359,246

G

deoxyuridine triphosphatase

affects expression

Ouabain affects the expression of DUT protein

NCBI chr15:48,331,095...48,343,373
Ensembl chr15:48,331,011...48,343,373

G

endothelin converting enzyme 1

increases expression

Ouabain results in increased expression of ECE1 protein

NCBI chr 1:21,217,250...21,345,504
Ensembl chr 1:21,217,247...21,345,572

G

enoyl-CoA hydratase, short chain 1

affects expression

Ouabain affects the expression of ECHS1 protein

NCBI chr10:133,362,485...133,373,354
Ensembl chr10:133,362,485...133,373,354

G

endothelin 1

increases expression
decreases expression

Ouabain results in increased expression of EDN1 mRNA
Ouabain results in decreased expression of EDN1 mRNA

PMID:15477225 PMID:28795476

NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194

G

endothelin receptor type A

increases expression

Ouabain results in increased expression of EDNRA mRNA; Ouabain results in increased expression of EDNRA protein

PMID:15477225 PMID:16982439

NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954

G

epidermal growth factor receptor

decreases phosphorylation

Ouabain results in decreased phosphorylation of EGFR protein

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

eukaryotic translation initiation factor 2A

increases expression

Ouabain results in increased expression of EIF2A protein

NCBI chr 3:150,546,787...150,586,016
Ensembl chr 3:150,546,678...150,586,016

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Ouabain results in increased expression of and results in increased phosphorylation of EIF2AK3 protein

NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518

G

eukaryotic translation initiation factor 3 subunit K

affects expression

Ouabain affects the expression of EIF3K protein

NCBI chr19:38,619,188...38,636,954
Ensembl chr19:38,619,082...38,636,955

G

endonuclease G

increases expression

Ouabain results in increased expression of ENDOG protein

NCBI chr 9:128,818,500...128,822,676
Ensembl chr 9:128,818,500...128,822,676

G

ERCC excision repair 4, endonuclease catalytic subunit

decreases expression

Ouabain results in decreased expression of ERCC4 mRNA

NCBI chr16:13,920,154...13,952,348
Ensembl chr16:13,920,138...13,952,348

G

ETS proto-oncogene 1, transcription factor

decreases expression

Ouabain results in decreased expression of ETS1 mRNA

NCBI chr11:128,458,765...128,587,558
Ensembl chr11:128,458,761...128,587,558

G

Fas associated via death domain

increases expression

Ouabain results in increased expression of FADD protein

NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390

G

FA complementation group D2

multiple interactions
decreases expression

Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]
Ouabain results in decreased expression of FANCD2 mRNA

NCBI chr 3:10,026,437...10,101,932
Ensembl chr 3:10,026,370...10,101,932

G

FA complementation group F

decreases expression

Ouabain results in decreased expression of FANCF mRNA

NCBI chr11:22,622,533...22,625,823
Ensembl chr11:22,622,533...22,625,823

G

FA complementation group I

decreases expression
multiple interactions

Ouabain results in decreased expression of FANCI mRNA
Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]

NCBI chr15:89,243,979...89,317,259
Ensembl chr15:89,243,945...89,317,261

G

phenylalanyl-tRNA synthetase 2, mitochondrial

increases expression

Ouabain results in increased expression of FARS2 mRNA

NCBI chr 6:5,249,934...5,771,583
Ensembl chr 6:5,261,044...5,829,192

G

Fas cell surface death receptor

increases expression

Ouabain results in increased expression of FAS protein

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fas ligand

increases expression

Ouabain results in increased expression of FASLG protein

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

F-box protein 32

multiple interactions

Ouabain affects the reaction [Botulinum Toxins, Type A affects the expression of FBXO32 mRNA]

NCBI chr 8:123,497,889...123,541,206
Ensembl chr 8:123,497,889...123,541,206

G

fumarate hydratase

affects expression

Ouabain affects the expression of FH protein

NCBI chr 1:241,497,603...241,519,755
Ensembl chr 1:241,497,511...241,519,799

G

FKBP prolyl isomerase 7

increases expression

Ouabain results in increased expression of FKBP7 mRNA

NCBI chr 2:178,463,664...178,478,600
Ensembl chr 2:178,463,664...178,478,600

G

fibronectin 1

decreases expression

Ouabain results in decreased expression of FN1 mRNA

NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073

G

GC vitamin D binding protein

affects expression

Ouabain affects the expression of GC protein

NCBI chr 4:71,741,693...71,805,520
Ensembl chr 4:71,741,696...71,804,041

G

glycine receptor beta

increases expression

Ouabain results in increased expression of GLRB mRNA

NCBI chr 4:157,076,150...157,172,090
Ensembl chr 4:157,076,125...157,172,090

G

growth factor receptor bound protein 2

decreases expression

Ouabain results in decreased expression of GRB2 protein

NCBI chr17:75,318,076...75,405,678
Ensembl chr17:75,318,076...75,405,709

G

GTP binding protein 6 (putative)

increases expression

Ouabain results in increased expression of GTPBP6 mRNA

NCBI chr  X:304,759...318,796
NCBI chr  Y:304,759...318,796
Ensembl chr  Y:304,529...318,796
Ensembl chr  X:304,529...318,796

G

H2A.X variant histone

increases phosphorylation

Ouabain results in increased phosphorylation of H2AX protein

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

hes related family bHLH transcription factor with YRPW motif 1

increases expression

Ouabain results in increased expression of HEY1 mRNA

NCBI chr 8:79,764,010...79,767,767
Ensembl chr 8:79,762,371...79,767,857

G

hepatocyte growth factor

multiple interactions

Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]

NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
affects localization
increases activity

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; Ouabain results in increased phosphorylation of and results in increased expression of HIF1A protein
Ouabain results in increased activity of HIF1A protein

NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259

G

heterogeneous nuclear ribonucleoprotein A2/B1

affects expression

Ouabain affects the expression of HNRNPA2B1 protein

NCBI chr 7:26,189,927...26,200,746
Ensembl chr 7:26,171,151...26,201,529

G

heterogeneous nuclear ribonucleoprotein D like

decreases expression

Ouabain results in decreased expression of HNRNPDL mRNA

NCBI chr 4:82,422,564...82,430,462
Ensembl chr 4:82,422,565...82,430,462

G

hippocalcin like 1

affects expression

Ouabain affects the expression of HPCAL1 protein

NCBI chr 2:10,302,904...10,427,604
Ensembl chr 2:10,302,889...10,427,617

G

histidine rich glycoprotein

affects expression

Ouabain affects the expression of HRG protein

NCBI chr 3:186,666,014...186,678,234
Ensembl chr 3:186,660,216...186,678,234

G

heat shock protein family A (Hsp70) member 5

increases expression

Ouabain results in increased expression of HSPA5 protein

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

heat shock protein family D (Hsp60) member 1

affects expression
multiple interactions

Ouabain affects the expression of HSPD1 protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]; Ouabain results in decreased expression of and affects the localization of HSPD1 protein

PMID:17268060 PMID:18247327

NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737

G

inhibitor of DNA binding 2

increases expression

Ouabain results in increased expression of ID2 mRNA

NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461

G

interleukin 2 receptor subunit alpha

decreases expression

Ouabain results in decreased expression of IL2RA mRNA

NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370

G

interleukin 2 receptor subunit beta

decreases expression

Ouabain results in decreased expression of IL2RB

NCBI chr22:37,125,838...37,175,118
Ensembl chr22:37,118,666...37,175,118

G

interleukin 6

increases secretion
increases expression

Ouabain results in increased secretion of IL6 protein
Ouabain results in increased expression of IL6 mRNA

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

interleukin 6 receptor

increases expression

Ouabain results in increased expression of IL6R mRNA

NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450

G

integrin linked kinase

decreases expression

Ouabain results in decreased expression of ILK mRNA

NCBI chr11:6,603,774...6,610,870
Ensembl chr11:6,603,708...6,610,874

G

integrin subunit alpha V

decreases expression

Ouabain results in decreased expression of ITGAV mRNA

NCBI chr 2:186,590,056...186,680,901
Ensembl chr 2:186,590,010...186,680,901

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
decreases phosphorylation

Ouabain results in decreased expression of JUN mRNA
Ouabain results in decreased phosphorylation of JUN protein

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

potassium voltage-gated channel subfamily D member 2

increases expression

Ouabain results in increased expression of KCND2 mRNA

NCBI chr 7:120,272,908...120,750,337
Ensembl chr 7:120,273,175...120,750,337

G

potassium voltage-gated channel subfamily H member 2

decreases expression
decreases activity
multiple interactions

Ouabain results in decreased expression of KCNH2 protein modified form
Ouabain results in decreased activity of KCNH2 protein
Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium]

PMID:19139152 PMID:21158687

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

G

lymphoid enhancer binding factor 1

decreases expression

Ouabain results in decreased expression of LEF1 mRNA

NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956

G

galectin 1

affects expression
increases expression

Ouabain affects the expression of LGALS1 protein
Ouabain results in increased expression of LGALS1 protein

PMID:17268060 PMID:18247327

NCBI chr22:37,675,636...37,679,802
Ensembl chr22:37,675,636...37,679,802

G

LIM domain kinase 1

decreases expression

Ouabain results in decreased expression of LIMK1 mRNA

NCBI chr 7:74,083,804...74,122,525
Ensembl chr 7:74,082,933...74,122,525

G

lanosterol synthase

increases abundance

LSS protein results in increased abundance of Ouabain

NCBI chr21:46,188,446...46,228,774
Ensembl chr21:46,188,141...46,228,824

G

mitogen-activated protein kinase kinase 6

increases expression

Ouabain results in increased expression of MAP2K6 mRNA

NCBI chr17:69,414,697...69,553,865
Ensembl chr17:69,414,697...69,553,865

G

mitogen-activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK1 protein]
Ouabain results in decreased phosphorylation of MAPK1 protein

PMID:19687166 PMID:28795476

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK3 protein]
Ouabain results in decreased phosphorylation of MAPK3 protein

PMID:19687166 PMID:28795476

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 7

multiple interactions

Ouabain inhibits the reaction [palytoxin results in increased phosphorylation of and results in increased activity of MAPK7 protein]

NCBI chr17:19,377,750...19,383,544
Ensembl chr17:19,377,721...19,383,544

G

malate dehydrogenase 2

affects expression

Ouabain affects the expression of MDH2 protein

NCBI chr 7:76,048,106...76,067,508
Ensembl chr 7:76,048,051...76,067,508

G

MDM2 proto-oncogene

multiple interactions

Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein

NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544

G

O-6-methylguanine-DNA methyltransferase

decreases expression

Ouabain results in decreased expression of MGMT protein

NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983

G

microRNA 29b-1

multiple interactions
decreases expression

MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]
Ouabain results in decreased expression of MIR29B1 mRNA

NCBI chr 7:130,877,459...130,877,539
Ensembl chr 7:130,877,459...130,877,539

G

matrix metallopeptidase 13

decreases expression

Ouabain results in decreased expression of MMP13 mRNA

NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732

G

matrix metallopeptidase 2

decreases expression
multiple interactions

Ouabain results in decreased expression of MMP2 mRNA
Ouabain results in decreased expression of and results in decreased activity of MMP2 protein

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 9

decreases expression

Ouabain results in decreased expression of MMP9 mRNA; Ouabain results in decreased expression of MMP9 protein

PMID:28795476 PMID:33760381

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

muscle RAS oncogene homolog

decreases expression

Ouabain results in decreased expression of MRAS mRNA

NCBI chr 3:138,347,648...138,405,535
Ensembl chr 3:138,347,648...138,405,534

G

myocardin related transcription factor A

decreases expression

Ouabain results in decreased expression of MRTFA mRNA

NCBI chr22:40,410,289...40,636,719
Ensembl chr22:40,410,281...40,636,719

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
increases expression

Ouabain results in decreased expression of MYC mRNA; Ouabain results in decreased expression of MYC protein
Ouabain results in increased expression of MYC protein

PMID:9653513 PMID:21215801

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

myosin light chain 12A

increases expression

Ouabain results in increased expression of MYL12A protein

NCBI chr18:3,247,482...3,256,237
Ensembl chr18:3,247,481...3,256,236

G

myosin light chain kinase

decreases expression

Ouabain results in decreased expression of MYLK mRNA

NCBI chr 3:123,610,049...123,884,332
Ensembl chr 3:123,610,049...123,884,332

G

nectin cell adhesion molecule 3

decreases expression

Ouabain results in decreased expression of NECTIN3 mRNA

NCBI chr 3:111,071,816...111,194,170
Ensembl chr 3:111,070,071...111,275,563

G

nectin cell adhesion molecule 4

increases expression

Ouabain results in increased expression of NECTIN4 mRNA

NCBI chr 1:161,070,998...161,089,558
Ensembl chr 1:161,070,998...161,089,558

G

neurofilament light chain

decreases expression

Ouabain results in decreased expression of NEFL mRNA

NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,956,721

G

nitric oxide synthase 1

affects expression
increases expression

Ouabain affects the expression of NOS1 protein
Ouabain results in increased expression of NOS1 protein

PMID:12384489 PMID:15097235

NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170

G

nitric oxide synthase 3

multiple interactions
affects expression
increases expression

5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide inhibits the reaction [Ouabain results in increased expression of NOS3 protein]
Ouabain affects the expression of NOS3 protein

PMID:12384489 PMID:15477225

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

G

NPC intracellular cholesterol transporter 2

decreases expression

Ouabain results in decreased expression of NPC2 mRNA

NCBI chr14:74,479,935...74,493,512
Ensembl chr14:74,476,192...74,494,177

G

natriuretic peptide A

increases expression
multiple interactions

Ouabain results in increased expression of NPPA mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:17266992 PMID:19687166

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

G

NRAS proto-oncogene, GTPase

decreases expression

Ouabain results in decreased expression of NRAS mRNA

NCBI chr 1:114,704,469...114,716,771
Ensembl chr 1:114,704,469...114,716,771

G

Parkinsonism associated deglycase

affects response to substance

PARK7 affects the susceptibility to Ouabain

NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505

G

poly(ADP-ribose) polymerase 1

multiple interactions
increases cleavage

Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein]; Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein]

PMID:24124520 PMID:31436044

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

proliferating cell nuclear antigen

decreases expression

Ouabain results in decreased expression of PCNA mRNA; Ouabain results in decreased expression of PCNA protein

PMID:20460749 PMID:21215801

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

G

programmed cell death 6

increases expression

Ouabain results in increased expression of PDCD6 protein

NCBI chr 5:271,646...314,974
Ensembl chr 5:271,621...314,974

G

prefoldin subunit 5

affects expression

Ouabain affects the expression of PFDN5 protein

NCBI chr12:53,295,542...53,299,450
Ensembl chr12:53,295,291...53,299,452

G

profilin 1

affects expression
decreases expression

Ouabain affects the expression of PFN1 protein
Ouabain results in decreased expression of PFN1 protein

PMID:17268060 PMID:18247327

NCBI chr17:4,945,652...4,948,530
Ensembl chr17:4,945,652...4,949,061

G

plasminogen activator, urokinase receptor

decreases expression

Ouabain results in decreased expression of PLAUR mRNA

NCBI chr19:43,646,095...43,670,169
Ensembl chr19:43,646,095...43,670,547

G

phospholipase C gamma 1

decreases expression

Ouabain results in decreased expression of PLCG1 mRNA

NCBI chr20:41,137,543...41,177,626
Ensembl chr20:41,136,960...41,196,801

G

palmitoyl-protein thioesterase 2

decreases expression

Ouabain results in decreased expression of PPT2 mRNA

NCBI chr 6:32,153,528...32,163,675
Ensembl chr 6:32,153,441...32,163,678

G

protein kinase, DNA-activated, catalytic subunit

decreases expression

Ouabain results in decreased expression of PRKDC protein

NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178

G

proteasome 20S subunit beta 6

affects expression

Ouabain affects the expression of PSMB6 protein

NCBI chr17:4,796,164...4,798,495
Ensembl chr17:4,796,144...4,798,502

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

[Ouabain results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Nitric Oxide

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

protein tyrosine phosphatase non-receptor type 2

decreases expression

Ouabain results in decreased expression of PTPN2 mRNA

NCBI chr18:12,785,478...12,884,237
Ensembl chr18:12,785,478...12,929,643

G

RAB11B, member RAS oncogene family

increases expression

Ouabain results in increased expression of RAB11B protein

NCBI chr19:8,390,360...8,404,434
Ensembl chr19:8,389,981...8,404,434

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases expression

Ouabain results in decreased expression of RAF1 mRNA

NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201

G

Ras protein specific guanine nucleotide releasing factor 1

decreases expression

Ouabain results in decreased expression of RASGRF1 mRNA

NCBI chr15:78,959,906...79,090,780
Ensembl chr15:78,959,906...79,090,780

G

regulator of G protein signaling 2

decreases expression

Ouabain results in decreased expression of RGS2 mRNA

NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275

G

ras homolog family member H

increases expression

Ouabain results in increased expression of RHOH mRNA

NCBI chr 4:40,191,080...40,246,967
Ensembl chr 4:40,191,011...40,246,967

G

Rho associated coiled-coil containing protein kinase 1

increases cleavage
multiple interactions

Ouabain results in increased cleavage of ROCK1 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein]

NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,944,612...21,111,813

G

Rho associated coiled-coil containing protein kinase 2

multiple interactions
increases cleavage

benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein]

NCBI chr 2:11,179,759...11,345,437
Ensembl chr 2:11,179,759...11,348,330

G

replication protein A3

affects expression

Ouabain affects the expression of RPA3 protein

NCBI chr 7:7,636,518...7,718,607
Ensembl chr 7:7,636,518...7,718,607

G

RPGRIP1 like

decreases expression

Ouabain results in decreased expression of RPGRIP1L mRNA

NCBI chr16:53,598,153...53,703,859
Ensembl chr16:53,598,153...53,703,938

G

ribosomal protein S6 kinase B1

affects expression

Ouabain affects the expression of RPS6KB1 mRNA

NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574

G

ryanodine receptor 2

multiple interactions
increases response to substance

K201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain]

NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988

G

S100 calcium binding protein A13

affects expression

Ouabain affects the expression of S100A13 protein

NCBI chr 1:153,618,799...153,634,361
Ensembl chr 1:153,618,787...153,631,360

G

S100 calcium binding protein B

increases expression

Ouabain results in increased expression of S100B protein

NCBI chr21:46,598,604...46,605,082
Ensembl chr21:46,598,604...46,605,208

G

serum/glucocorticoid regulated kinase 1

multiple interactions
decreases expression

Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium]
Ouabain results in decreased expression of SGK1 mRNA

PMID:12590200 PMID:28795476

NCBI chr 6:134,169,256...134,318,112
Ensembl chr 6:134,169,248...134,318,112

G

serum/glucocorticoid regulated kinase 2

multiple interactions

Ouabain inhibits the reaction [SGK2 protein results in increased transport of Potassium]

NCBI chr20:43,559,027...43,585,627
Ensembl chr20:43,558,968...43,588,237

G

serum/glucocorticoid regulated kinase family member 3

multiple interactions

Ouabain inhibits the reaction [SGK3 protein results in increased transport of Potassium]

NCBI chr 8:66,712,781...66,862,022
Ensembl chr 8:66,712,734...66,862,022

G

SHC adaptor protein 3

increases expression

Ouabain results in increased expression of SHC3 mRNA

NCBI chr 9:89,005,771...89,178,818
Ensembl chr 9:89,005,771...89,178,818

G

solute carrier family 16 member 1

multiple interactions

Ouabain inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]

NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593

G

solute carrier family 22 member 12

multiple interactions

Ouabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]

NCBI chr11:64,591,220...64,602,344
Ensembl chr11:64,590,641...64,602,353

G

solute carrier family 5 member 5

multiple interactions

Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]

NCBI chr19:17,871,945...17,895,174
Ensembl chr19:17,871,945...17,895,174

G

solute carrier family 5 member 6

multiple interactions

Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]

NCBI chr 2:27,199,587...27,212,787
Ensembl chr 2:27,199,587...27,212,958

G

solute carrier family 8 member A1

affects response to substance
increases expression
multiple interactions

SLC8A1 affects the susceptibility to Ouabain
Ouabain results in increased expression of SLC8A1 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]

PMID:16166162 PMID:19897708

NCBI chr 2:40,097,270...40,512,435
Ensembl chr 2:40,097,270...40,611,053

G

solute carrier family 9 member A1

multiple interactions
increases expression

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of SLC9A1 mRNA]

NCBI chr 1:27,098,809...27,155,125
Ensembl chr 1:27,098,809...27,166,981

G

SMAD family member 4

decreases expression

Ouabain results in decreased expression of SMAD4 mRNA

NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045

G

snail family transcriptional repressor 1

decreases expression

Ouabain results in decreased expression of SNAI1 mRNA

NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

Ouabain results in decreased expression of SOS1 protein

NCBI chr 2:38,981,549...39,124,868
Ensembl chr 2:38,962,206...39,124,345

G

SOS Ras/Rho guanine nucleotide exchange factor 2

decreases expression

Ouabain results in decreased expression of SOS2 mRNA

NCBI chr14:50,117,130...50,231,882
Ensembl chr14:50,117,130...50,231,578

G

sphingosine kinase 1

decreases expression

Ouabain results in decreased expression of SPHK1 mRNA

NCBI chr17:76,383,204...76,387,855
Ensembl chr17:76,376,584...76,387,860

G

transforming growth factor beta 1

decreases expression

Ouabain results in decreased expression of TGFB1 mRNA

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

transforming growth factor beta 2

decreases expression

Ouabain results in decreased expression of TGFB2 mRNA

NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619

G

transforming growth factor beta 3

decreases expression

Ouabain results in decreased expression of TGFB3 mRNA

NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011

G

transforming growth factor beta receptor 3

increases expression

Ouabain results in increased expression of TGFBR3 mRNA

NCBI chr 1:91,680,343...91,906,002
Ensembl chr 1:91,680,343...91,906,335

G

talin 1

decreases expression

Ouabain results in decreased expression of TLN1 mRNA

NCBI chr 9:35,696,948...35,732,195
Ensembl chr 9:35,696,948...35,732,195

G

talin 2

decreases expression

Ouabain results in decreased expression of TLN2 mRNA

NCBI chr15:62,390,550...62,844,631
Ensembl chr15:62,390,526...62,844,631

G

TNF receptor superfamily member 10a

increases expression

Ouabain results in increased expression of TNFRSF10A protein

NCBI chr 8:23,190,452...23,225,102
Ensembl chr 8:23,190,452...23,225,102

G

TNF receptor superfamily member 10b

increases expression

Ouabain results in increased expression of TNFRSF10B protein

NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031

G

tumor protein p53

multiple interactions

Ouabain results in decreased expression of and results in increased phosphorylation of TP53 protein

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

triosephosphate isomerase 1

affects expression

Ouabain affects the expression of TPI1 protein

NCBI chr12:6,867,420...6,870,948
Ensembl chr12:6,867,119...6,870,948

G

tumor protein, translationally-controlled 1

affects expression

Ouabain affects the expression of TPT1 protein

NCBI chr13:45,333,471...45,341,183
Ensembl chr13:45,333,471...45,341,284

G

tripartite motif containing 63

multiple interactions

[Ouabain co-treated with Botulinum Toxins, Type A] affects the expression of TRIM63 mRNA

NCBI chr 1:26,051,301...26,067,630
Ensembl chr 1:26,051,301...26,068,436

G

transient receptor potential cation channel subfamily C member 1

increases expression

Ouabain results in increased expression of TRPC1 protein

NCBI chr 3:142,724,034...142,807,888
Ensembl chr 3:142,724,034...142,807,888

G

transient receptor potential cation channel subfamily C member 6

increases expression
multiple interactions

Ouabain results in increased expression of TRPC6 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]

NCBI chr11:101,451,564...101,584,007
Ensembl chr11:101,451,564...101,872,562

G

twist family bHLH transcription factor 1

increases expression

Ouabain results in increased expression of TWIST1 mRNA

NCBI chr 7:19,113,047...19,117,636
Ensembl chr 7:19,020,991...19,117,636

G

thioredoxin

affects expression

Ouabain affects the expression of TXN protein

NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507

G

vimentin

decreases expression

Ouabain results in decreased expression of VIM mRNA

NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593

G

zinc finger homeobox 3

decreases expression

Ouabain results in decreased expression of ZFHX3 mRNA

NCBI chr16:72,782,885...73,891,930
Ensembl chr16:72,782,885...73,891,871

ponasterone A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

decreases activity
multiple interactions

ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

dynamin 1 like

multiple interactions

[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of DNM1L protein

NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650

G

fragile histidine triad diadenosine triphosphatase

affects expression

ponasterone A affects the expression of FHIT protein

NCBI chr 3:59,747,277...61,251,452
Ensembl chr 3:59,747,277...61,251,459

G

fission, mitochondrial 1

multiple interactions

[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein]

NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316

G

mitofusin 2

increases expression

[ponasterone A results in increased expression of PINK1 protein] which results in increased expression of MFN2 protein

NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211

G

PTEN induced kinase 1

increases expression
multiple interactions

[ponasterone A results in increased expression of PINK1 protein] which results in increased expression of MFN2 protein; ponasterone A results in increased expression of PINK1 protein
[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of DNM1L protein; [ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein]

NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein]

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

UDP glucuronosyltransferase family 1 member A3

increases expression

ponasterone A results in increased expression of UGT1A3 protein

NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300

strophanthidin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

increases transport

ABCB1 protein results in increased transport of Strophanthidin

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

glucose-6-phosphatase catalytic subunit 1

increases expression
multiple interactions

Strophanthidin results in increased expression of G6PC1 mRNA
Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]

NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438

G

interleukin 17A

multiple interactions

Strophanthidin results in increased expression of and results in increased secretion of IL17A protein

NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638

G

interleukin 17F

multiple interactions

Strophanthidin results in increased expression of and results in increased secretion of IL17F protein

NCBI chr 6:52,236,681...52,245,689
Ensembl chr 6:52,236,681...52,245,689

G

neuronal PAS domain protein 2

increases expression
multiple interactions

Strophanthidin results in increased expression of NPAS2 mRNA
Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 2:100,818,723...100,996,829
Ensembl chr 2:100,820,139...100,996,829

G

RAR related orphan receptor C

increases expression
multiple interactions

Strophanthidin results in increased expression of RORC mRNA
RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26041
chemical entity	26020
molecular entity	25998
polyatomic entity	25883
heteroatomic molecular entity	25534
hydroxides	24056
organic hydroxy compound	22071
hydroxy steroid	15543
14-hydroxy steroid	277
14alpha-hydroxy steroid +	18
14beta-hydroxy steroid +	266
Path 2
Term	Annotations
CHEBI ontology	26041
subatomic particle	26016
composite particle	26016
hadron	26016
baryon	26016
nucleon	26016
atomic nucleus	26016
atom	26016
main group element atom	25841
p-block element atom	25841
carbon group element atom	25441
carbon atom	25399
organic molecular entity	25399
organic molecule	25228
organic cyclic compound	24281
organic polycyclic compound	18804
steroid	15866
hydroxy steroid	15543
14-hydroxy steroid	277
14alpha-hydroxy steroid +	18
14beta-hydroxy steroid +	266

paths to the root