14-hydroxy steroid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	14-hydroxy steroid	go back to main search page
Accession:	CHEBI:36860	browse the term
Synonyms:	related_synonym:	14-hydroxy steroids

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Rat (278) Mouse (278) Human (280) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (2) Green Monkey (0) Naked Mole-rat (0) All
Genes (278)

20-hydroxyecdysone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BCL2 associated X, apoptosis regulator

increases expression

Ecdysterone results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

affects expression

Ecdysterone affects the expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

increases activity
increases cleavage

Ecdysterone results in increased activity of CASP3 protein
Ecdysterone results in increased cleavage of CASP3 protein

PMID:29126784 PMID:33878320

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

glycogen synthase kinase 3 beta

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

heme oxygenase 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 5

decreases expression
increases expression

Ecdysterone results in decreased expression of HSPA5 protein
Ecdysterone results in increased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

mechanistic target of rapamycin kinase

affects expression

Ecdysterone affects the expression of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases response to substance

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

poly (ADP-ribose) polymerase 1

increases cleavage

Ecdysterone results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

sequestosome 1

affects expression

Ecdysterone affects the expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

bufalin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

bufalin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

actin, beta

increases expression

bufalin results in increased expression of ACTB protein

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin, gamma 1

increases expression

bufalin results in increased expression of ACTG1 protein

NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

bufalin results in increased phosphorylation of and results in decreased expression of AKT1 protein
bufalin results in decreased phosphorylation of AKT1 protein

PMID:23949904 PMID:36924737

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

apoptotic peptidase activating factor 1

increases expression

bufalin results in increased expression of APAF1 protein

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

BCL2, apoptosis regulator

decreases expression

bufalin results in decreased expression of BCL2 mRNA; bufalin results in decreased expression of BCL2 protein

PMID:7658701 PMID:27444971

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 11

increases expression

bufalin results in increased expression of BCL2L11 protein

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

caspase 3

increases expression
increases activity

bufalin results in increased expression of CASP3 mRNA; bufalin results in increased expression of CASP3 protein modified form
bufalin results in increased activity of CASP3 protein

PMID:27444971 PMID:36924737

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity

bufalin results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

COPI coat complex subunit epsilon

decreases expression

bufalin results in decreased expression of COPE protein

NCBI chr16:19,114,871...19,125,076
Ensembl chr16:19,114,871...19,128,907

G

cytochrome c, somatic

multiple interactions
increases expression

bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]; HSPB1 protein inhibits the reaction [bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]]
bufalin results in increased expression of CYCS protein

PMID:23091618 PMID:27444971

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing
multiple interactions
increases expression

CYP3A4 protein results in increased metabolism of bufalin
bufalin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; bufalin results in increased expression of and results in increased activity of CYP3A4 protein; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufalin]
bufalin results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

DNA-damage inducible transcript 3

increases expression

bufalin results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

bufalin results in increased expression of DNAJB11 protein

NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407

G

deoxyuridine triphosphatase

decreases expression

bufalin results in decreased expression of DUT protein

NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771

G

eukaryotic translation initiation factor 2 alpha kinase 3

decreases phosphorylation

bufalin results in decreased phosphorylation of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

endonuclease G

increases expression

bufalin results in increased expression of ENDOG mRNA; bufalin results in increased expression of ENDOG protein

NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932

G

enolase 1

decreases expression

bufalin results in decreased expression of ENO1 protein

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

G

Fas cell surface death receptor

increases expression

bufalin results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

bufalin results in increased expression of FASLG protein

PMID:27444971 PMID:36924737

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased expression of FOS mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bufalin results in increased expression of FOS mRNA]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box O1

multiple interactions

bufalin results in increased expression of and results in decreased phosphorylation of FOXO1 protein

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

growth factor receptor bound protein 2

decreases expression

bufalin results in decreased expression of GRB2 protein

NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309

G

glutathione S-transferase pi 1

decreases expression

bufalin results in decreased expression of GSTP1 protein

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

heterogeneous nuclear ribonucleoprotein H1

decreases expression

bufalin results in decreased expression of HNRNPH1 protein

NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846

G

heterogeneous nuclear ribonucleoprotein K

decreases expression

bufalin results in decreased expression of HNRNPK protein

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

G

heat shock protein family A (Hsp70) member 5

decreases expression

bufalin results in decreased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 1

multiple interactions
decreases response to substance
decreases expression

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [bufalin results in decreased expression of HSPB1 protein]; bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]; HSPB1 protein inhibits the reaction [bufalin affects the localization of RELA protein]; HSPB1 protein inhibits the reaction [bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]]; HSPB1 protein inhibits the reaction [bufalin results in increased cleavage of PARP1 protein]
HSPB1 protein results in decreased susceptibility to bufalin

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

interleukin 1 beta

multiple interactions
increases expression

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; Ro 31-8220 inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; SB 203580 promotes the reaction [bufalin results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases phosphorylation

bufalin results in decreased phosphorylation of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

keratin 18

increases expression

bufalin results in increased expression of KRT18 protein

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166

G

mitogen activated protein kinase kinase 7

decreases expression

bufalin results in decreased expression of MAP2K7 protein

NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222

G

mitogen activated protein kinase kinase kinase 3

decreases expression

bufalin results in decreased expression of MAP3K3 protein

NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
decreases activity
increases phosphorylation

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]; Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [bufalin results in increased phosphorylation of MAPK1 protein]
bufalin results in decreased phosphorylation of MAPK1 protein
bufalin results in decreased activity of MAPK1 protein

PMID:10712238 PMID:21922632 PMID:36924737

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
decreases activity
increases phosphorylation

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased phosphorylation of MAPK3 protein]; Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [bufalin results in increased phosphorylation of MAPK3 protein]
bufalin results in decreased phosphorylation of MAPK3 protein
bufalin results in decreased activity of MAPK3 protein

PMID:10712238 PMID:21922632 PMID:36924737

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

decreases activity

bufalin results in decreased activity of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

decreases activity

bufalin results in decreased activity of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

bufalin co-treated with osimertinib decreases expression of MCL1 protein in lung
Bufalin decreases expression of MCL1 protein in lung

RGD

PMID:31301315 PMID:28419994

RGD:151356917, RGD:151356918

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

marker of proliferation Ki-67

decreases expression

bufalin results in decreased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 1

decreases expression

bufalin results in decreased expression of MMP1 protein

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 2

multiple interactions
decreases secretion
decreases expression

bufalin results in decreased expression of and results in decreased activity of MMP2 protein
bufalin results in decreased secretion of MMP2 protein
bufalin results in decreased expression of MMP2 mRNA

PMID:21922632 PMID:23949904

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases activity
decreases secretion
multiple interactions
decreases expression

bufalin results in decreased activity of MMP9 protein
bufalin results in decreased secretion of MMP9 protein
bufalin results in decreased expression of and results in decreased activity of MMP9 protein
bufalin results in decreased expression of MMP9 mRNA

PMID:21922632 PMID:23949904

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

bufalin results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nitric oxide synthase 2

decreases expression

bufalin results in decreased expression of NOS2 protein

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

bufalin results in increased cleavage of PARP1 protein
HSPB1 protein inhibits the reaction [bufalin results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

inorganic pyrophosphatase 1

decreases expression

bufalin results in decreased expression of PPA1 protein

NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215

G

protein phosphatase 2 catalytic subunit beta

decreases expression

bufalin results in decreased expression of PPP2CB protein

NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576

G

proteasome 20S subunit alpha 3

decreases expression

bufalin results in decreased expression of PSMA3 protein

NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965

G

prostaglandin-endoperoxide synthase 2

decreases expression

bufalin results in decreased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

decreases expression

bufalin results in decreased expression of PTK2 protein

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

RELA proto-oncogene, NF-kB subunit

decreases expression
multiple interactions
affects localization

bufalin results in decreased expression of RELA protein
HSPB1 protein inhibits the reaction [bufalin affects the localization of RELA protein]

PMID:23091618 PMID:23949904

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ras homolog family member A

decreases expression

bufalin results in decreased expression of RHOA protein

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

Rho-associated coiled-coil containing protein kinase 1

decreases expression

bufalin results in decreased expression of ROCK1 protein

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

ribosomal protein lateral stalk subunit P0

decreases expression

bufalin results in decreased expression of RPLP0 protein

NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632

G

ribosomal protein SA

increases expression

bufalin results in increased expression of RPSA protein

NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247

G

SAP domain containing ribonucleoprotein

increases expression

bufalin results in increased expression of SARNP protein

NCBI chr 7:1,251,096...1,305,335
Ensembl chr 7:1,251,098...1,305,332

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

bufalin results in decreased expression of SOS1 protein

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

TAR DNA binding protein

decreases expression

bufalin results in decreased expression of TARDBP protein

NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055

G

t-complex 1

decreases expression

bufalin results in decreased expression of TCP1 protein

NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839

G

tropomodulin 3

decreases expression

bufalin results in decreased expression of TMOD3 protein

NCBI chr 8:76,248,978...76,310,855
Ensembl chr 8:76,248,979...76,310,977

G

tumor necrosis factor

increases expression
multiple interactions

bufalin results in increased expression of TNF mRNA
SB 203580 promotes the reaction [bufalin results in increased expression of TNF mRNA]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

triosephosphate isomerase 1

decreases expression

bufalin results in decreased expression of TPI1 protein

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

tumor protein, translationally-controlled 1

decreases expression

bufalin results in decreased expression of TPT1 protein

NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625

G

vascular endothelial growth factor A

decreases expression

bufalin results in decreased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

digitoxigenin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

decreases expression

Digitoxigenin results in decreased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 4

decreases expression

Digitoxigenin results in decreased expression of CCL4 protein

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

decreases expression

Digitoxigenin results in decreased expression of CCL5 protein

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

interleukin 6 receptor

decreases expression

Digitoxigenin results in decreased expression of IL6R protein modified form

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

vascular endothelial growth factor A

decreases expression

Digitoxigenin results in decreased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

digitoxin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions
increases transport

Digitoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
ABCB1 protein results in increased transport of Digitoxin

PMID:23104431 PMID:26708294

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

androgen receptor

multiple interactions

Digitoxin binds to and results in decreased activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

baculoviral IAP repeat-containing 5

decreases expression

Digitoxin analog results in decreased expression of BIRC5 protein; Digitoxin results in decreased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

caspase 3

decreases expression
multiple interactions

Digitoxin analog results in decreased expression of CASP3 protein; Digitoxin results in decreased expression of CASP3 protein
Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]]

PMID:22037315 PMID:34717917

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases cleavage
multiple interactions

Digitoxin analog results in increased cleavage of CASP8 protein; Digitoxin results in increased cleavage of CASP8 protein
Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]

PMID:22037315 PMID:34717917

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases cleavage

Digitoxin analog results in increased cleavage of CASP9 protein; Digitoxin results in increased cleavage of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

C-C motif chemokine ligand 2

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin B1

multiple interactions
decreases expression

Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]
Digitoxin analog results in decreased expression of CCNB1 protein; Digitoxin results in decreased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

multiple interactions
decreases expression

Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]; Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]]
Digitoxin results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase 1

decreases expression
multiple interactions

Digitoxin analog results in decreased expression of CDK1 protein; Digitoxin results in decreased expression of CDK1 protein
Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase inhibitor 1A

decreases expression

Digitoxin analog results in decreased expression of CDKN1A protein; Digitoxin results in decreased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

decreases expression

Digitoxin analog results in decreased expression of CDKN1B protein; Digitoxin results in decreased expression of CDKN1B protein

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

checkpoint kinase 1

decreases expression

Digitoxin analog results in decreased expression of CHEK1 protein; Digitoxin results in decreased expression of CHEK1 protein

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

decreases expression

Digitoxin analog results in decreased expression of CHEK2 protein; Digitoxin results in decreased expression of CHEK2 protein

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

cytochrome c, somatic

increases expression

Digitoxin analog results in increased expression of CYCS protein; Digitoxin results in increased expression of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
decreases phosphorylation

Digitoxin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of EIF4EBP1 protein]
Digitoxin results in decreased phosphorylation of EIF4EBP1 protein

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

estrogen receptor 1

multiple interactions

Digitoxin binds to and results in decreased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

Digitoxin binds to and results in decreased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

FA complementation group D2

multiple interactions

Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]

NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412

G

FA complementation group I

multiple interactions

Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]

NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]; Digitoxin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Digitoxin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

interleukin 1 beta

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

mitogen activated protein kinase 1

multiple interactions

Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

nuclear factor kappa B subunit 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

decreases phosphorylation

Digitoxin results in decreased phosphorylation of NFKBIA protein

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 3

multiple interactions
increases activity

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin results in increased activity of NOS3 protein]; Calcium deficiency inhibits the reaction [Digitoxin results in increased activity of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

progesterone receptor

multiple interactions

Digitoxin binds to and results in decreased activity of PGR protein

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

protein inhibitor of activated STAT, 3

increases expression

Digitoxin results in increased expression of PIAS3 protein

NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:184,232,571...184,241,480

G

phosphatase and tensin homolog

increases expression

Digitoxin results in increased expression of PTEN protein

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

protein tyrosine phosphatase, non-receptor type 6

increases expression

Digitoxin results in increased expression of PTPN6 protein

NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984

G

ribosomal protein S6 kinase B1

decreases phosphorylation
multiple interactions

Digitoxin results in decreased phosphorylation of RPS6KB1 protein
[Digitoxin co-treated with Oxygen deficiency] results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

signal transducer and activator of transcription 3

multiple interactions

[Digitoxin co-treated with Oxygen deficiency] results in decreased expression of and results in decreased phosphorylation of STAT3 protein; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]; Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]; Digitoxin results in decreased expression of and results in decreased phosphorylation of STAT3 protein; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

thyroid hormone receptor alpha

multiple interactions

Digitoxin binds to and results in decreased activity of THRA protein

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

thyroid hormone receptor beta

multiple interactions

Digitoxin binds to and results in decreased activity of THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

tumor protein p53

decreases expression

Digitoxin analog results in decreased expression of TP53 protein; Digitoxin results in decreased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

vascular cell adhesion molecule 1

multiple interactions

Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

digoxigenin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases transport

ABCB1 protein results in increased transport of Digoxigenin

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

C-C motif chemokine ligand 2

decreases expression

Digoxigenin results in decreased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 4

decreases expression

Digoxigenin results in decreased expression of CCL4 protein

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions
increases expression

Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter]
Digoxigenin results in increased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

interleukin 17A

multiple interactions

Digoxigenin results in increased expression of and results in increased secretion of IL17A protein

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 17F

multiple interactions

Digoxigenin results in increased expression of and results in increased secretion of IL17F protein

NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482

G

interleukin 6 receptor

decreases expression

Digoxigenin results in decreased expression of IL6R protein modified form

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

neuronal PAS domain protein 2

increases expression
multiple interactions

Digoxigenin results in increased expression of NPAS2 mRNA
Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320

G

RAR-related orphan receptor C

increases expression
multiple interactions

Digoxigenin results in increased expression of RORC mRNA
Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter]; Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [Digoxigenin results in increased expression of RORC mRNA]

NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907

G

vascular endothelial growth factor A

decreases expression

Digoxigenin results in decreased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

dihydroouabain

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions
increases expression

dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]
dihydroouabain results in increased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

interleukin 17A

multiple interactions

dihydroouabain results in increased expression of and results in increased secretion of IL17A protein

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 17F

multiple interactions

dihydroouabain results in increased expression of and results in increased secretion of IL17F protein

NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482

G

neuronal PAS domain protein 2

increases expression
multiple interactions

dihydroouabain results in increased expression of NPAS2 mRNA
dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320

G

RAR-related orphan receptor C

multiple interactions
increases expression

dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]; dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [dihydroouabain results in increased expression of RORC mRNA]

NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907

hellebrigenin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

hellebrigenin results in decreased phosphorylation of and results in decreased expression of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

ATM serine/threonine kinase

increases phosphorylation

hellebrigenin results in increased phosphorylation of ATM protein

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

BCL2 associated X, apoptosis regulator

affects localization

hellebrigenin affects the localization of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

cyclin B1

increases expression

hellebrigenin results in increased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cell division cycle 25C

decreases phosphorylation

hellebrigenin results in decreased phosphorylation of CDC25C protein

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cyclin-dependent kinase 1

increases phosphorylation

hellebrigenin results in increased phosphorylation of CDK1 protein

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

checkpoint kinase 2

increases phosphorylation

hellebrigenin results in increased phosphorylation of CHEK2 protein

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

poly (ADP-ribose) polymerase 1

increases activity

hellebrigenin results in increased activity of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

helveticoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RAR-related orphan receptor C

increases expression

helveticoside results in increased expression of RORC mRNA

NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907

oleandrin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity

oleandrin results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

oleandrin results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

C-X-C motif chemokine receptor 1

increases expression

oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein

NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084

G

C-X-C motif chemokine receptor 2

increases expression

oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein

NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425

G

C-X-C motif chemokine receptor 4

increases expression

oleandrin results in increased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

ouabain

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

affects expression

Ouabain affects the expression of A2M protein

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily B member 1A

multiple interactions
increases expression

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; [Ouabain results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]
Ouabain results in increased expression of ABCB1 mRNA; Ouabain results in increased expression of ABCB1 protein

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

acetyl-CoA acyltransferase 2

affects expression

Ouabain affects the expression of ACAA2 protein

NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249

G

angiotensin I converting enzyme

affects expression

Ouabain affects the expression of ACE mRNA; Ouabain affects the expression of ACE protein

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

actin alpha 2, smooth muscle

affects expression

Ouabain affects the expression of ACTA2 protein

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

affects expression

Ouabain affects the expression of ADH1C protein

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

angiotensinogen

affects expression
increases expression

Ouabain affects the expression of AGT protein
Ouabain results in increased expression of AGT protein

PMID:11768735 PMID:16565308

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

decreases expression
affects expression

Ouabain results in decreased expression of AGTR1A protein
Ouabain affects the expression of AGTR1A mRNA

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

apoptosis inducing factor, mitochondria associated 1

increases expression

Ouabain results in increased expression of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

annexin A1

affects expression

Ouabain affects the expression of ANXA1 protein

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A2

affects expression

Ouabain affects the expression of ANXA2 protein

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

apoptotic peptidase activating factor 1

increases expression

Ouabain results in increased expression of APAF1 protein

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

A-Raf proto-oncogene, serine/threonine kinase

decreases expression

Ouabain results in decreased expression of ARAF mRNA

NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073

G

ariadne RBR E3 ubiquitin protein ligase 1

decreases expression

Ouabain results in decreased expression of ARIH1 mRNA

NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245

G

actin related protein 2/3 complex, subunit 5

affects expression

Ouabain affects the expression of ARPC5 protein

NCBI chr13:64,904,504...64,913,413
Ensembl chr13:64,887,136...64,913,410

G

arrestin, beta 1

increases expression

Ouabain results in increased expression of ARRB1 mRNA

NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061

G

N-acylsphingosine amidohydrolase 1

affects expression

Ouabain affects the expression of ASAH1 protein

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

activating transcription factor 6 beta

increases expression

Ouabain results in increased expression of ATF6B protein

NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894

G

ATM serine/threonine kinase

increases phosphorylation

Ouabain results in increased phosphorylation of ATM protein

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase H+/K+ transporting non-gastric alpha2 subunit

multiple interactions

Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium]

NCBI chr15:30,443,571...30,468,229
Ensembl chr15:30,443,571...30,468,229

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions
increases expression
affects expression
affects binding

Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA]; Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein]
Ouabain affects the expression of ATP1A1 protein
Ouabain results in increased expression of ATP1A1 mRNA; Ouabain results in increased expression of ATP1A1 protein
Ouabain binds to ATP1A1 protein

PMID:11768735 PMID:11834625 PMID:12479229 PMID:16716361 PMID:19995221

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATPase Na+/K+ transporting subunit alpha 2

multiple interactions
increases expression
decreases expression
affects expression
decreases activity
affects response to substance
affects binding

Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA]
Ouabain results in increased expression of ATP1A2 protein
Ouabain results in decreased expression of ATP1A2 mRNA
Ouabain affects the expression of ATP1A2 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA]
Ouabain results in decreased activity of ATP1A2 protein
Ouabain binds to and results in decreased activity of ATP1A2 protein
ATP1A2 protein affects the susceptibility to Ouabain
Ouabain binds to ATP1A2 protein

PMID:11834625 PMID:12479229 PMID:15458945 PMID:16166162 PMID:16716361 More...

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATPase Na+/K+ transporting subunit alpha 3

increases expression
multiple interactions
decreases expression
affects expression
affects binding

Ouabain results in increased expression of ATP1A3 mRNA; Ouabain results in increased expression of ATP1A3 protein
Potassium Chloride inhibits the reaction [ATP1A3 protein binds to Ouabain]
Ouabain results in decreased expression of ATP1A3 mRNA
Ouabain affects the expression of ATP1A3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A3 mRNA]
ATP1A3 protein binds to Ouabain; Ouabain binds to ATP1A3 protein

PMID:11204457 PMID:12479229 PMID:15276875 PMID:19687166 PMID:19995221 More...

NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918

G

ATPase Na+/K+ transporting subunit beta 1

multiple interactions
increases expression

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; Calcium affects the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; W 7 inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

ATPase H+/K+ transporting subunit beta

multiple interactions

Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium]

NCBI chr16:76,144,150...76,153,063
Ensembl chr16:76,144,150...76,153,063

G

ATP synthase F1 subunit alpha

affects expression

Ouabain affects the expression of ATP5F1A protein

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

ATR serine/threonine kinase

decreases phosphorylation

Ouabain results in decreased phosphorylation of ATR protein

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

bromo adjacent homology domain containing 1

decreases expression

Ouabain results in decreased expression of BAHD1 mRNA

NCBI chr 3:105,891,207...105,914,414
Ensembl chr 3:105,892,478...105,914,410

G

BCL2 associated X, apoptosis regulator

affects localization
increases expression
multiple interactions

Ouabain affects the localization of BAX protein
Ouabain results in increased expression of BAX protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]

PMID:17096883 PMID:18247327 PMID:31436044

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

Ouabain results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

Ouabain results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

brain-derived neurotrophic factor

multiple interactions
decreases expression

Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein]

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

BRCA1, DNA repair associated

decreases expression

Ouabain results in decreased expression of BRCA1 protein

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

calbindin 1

decreases expression

Ouabain results in decreased expression of CALB1 protein

NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431

G

calmodulin-like 5

affects expression

Ouabain affects the expression of CALML5 protein

NCBI chr17:66,394,433...66,395,352

G

calcium/calmodulin-dependent protein kinase II beta

increases expression

Ouabain results in increased expression of CAMK2B protein

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

calnexin

increases expression

Ouabain results in increased expression of CANX protein

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

caspase 3

increases expression
multiple interactions
increases activity

Ouabain results in increased expression of CASP3 protein
Ouabain results in increased activity of and results in increased cleavage of CASP3 protein
Ouabain results in increased activity of CASP3 protein

PMID:11435898 PMID:17096883 PMID:18247327 PMID:20435043 PMID:31436044

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases expression

Ouabain results in increased expression of CASP4 protein

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 8

multiple interactions

Ouabain results in increased expression of and results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

Ouabain results in increased expression of and results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases activity

Lithium inhibits the reaction [Ouabain results in decreased activity of CAT protein]; Valproic Acid inhibits the reaction [Ouabain results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

decreases expression

Ouabain results in decreased expression of CAV1 mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

coiled-coil domain containing 14

decreases expression

Ouabain results in decreased expression of CCDC14 mRNA

NCBI chr11:66,052,063...66,087,915
Ensembl chr11:66,052,620...66,087,956

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 protein]
Ouabain results in increased expression of CCL2 mRNA; Ouabain results in increased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin A1

decreases expression

Ouabain results in decreased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin A2

decreases expression

Ouabain results in decreased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin D1

decreases expression

Ouabain results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cadherin 1

decreases expression
increases expression

Ouabain results in decreased expression of CDH1 protein
Ouabain results in increased expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

decreases expression

Ouabain results in decreased expression of CDH2 mRNA; Ouabain results in decreased expression of CDH2 protein

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin dependent kinase 2

decreases expression

Ouabain results in decreased expression of CDK2 mRNA; Ouabain results in decreased expression of CDK2 protein

PMID:20460749 PMID:21215801 PMID:31436044

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 6

decreases expression

Ouabain results in decreased expression of CDK6 protein

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

decreases expression
increases expression

Ouabain results in decreased expression of CDKN1A mRNA; Ouabain results in decreased expression of CDKN1A protein
Ouabain results in increased expression of CDKN1A mRNA; Ouabain results in increased expression of CDKN1A protein

PMID:20460749 PMID:21215801 PMID:28795476 PMID:31436044

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

creatine kinase B

decreases activity

Ouabain results in decreased activity of CKB protein

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

claudin 1

decreases expression

Ouabain results in decreased expression of CLDN1 protein

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

canopy FGF signaling regulator 2

affects expression

Ouabain affects the expression of CNPY2 protein

NCBI chr 7:748,877...754,352
Ensembl chr 7:749,008...755,519

G

collagen type I alpha 1 chain

multiple interactions
increases expression

MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

citrate synthase

decreases activity

Ouabain results in decreased activity of CS protein

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

cytochrome c-1

multiple interactions

Ouabain results in decreased expression of and affects the localization of CYC1 protein

NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479

G

DNA-damage inducible transcript 3

increases expression

Ouabain results in increased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

decreases expression

Ouabain results in decreased expression of DDOST mRNA

NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413

G

DnaJ heat shock protein family (Hsp40) member A3

increases expression

Ouabain results in increased expression of DNAJA3 mRNA

NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161

G

dopamine receptor D1

multiple interactions
decreases expression

Ouabain results in decreased expression of and results in increased phosphorylation of DRD1 protein
Ouabain results in increased phosphorylation of and results in decreased expression of DRD1 protein
Ouabain results in decreased expression of DRD1 mRNA

PMID:19626329 PMID:20132239

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

desmoglein 1

affects expression

Ouabain affects the expression of DSG1 protein

NCBI chr18:11,674,687...11,705,383
Ensembl chr18:11,674,402...11,703,443

G

deoxyuridine triphosphatase

affects expression

Ouabain affects the expression of DUT protein

NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771

G

endothelin converting enzyme 1

increases expression

Ouabain results in increased expression of ECE1 protein

NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371

G

enoyl-CoA hydratase, short chain 1

affects expression

Ouabain affects the expression of ECHS1 protein

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

endothelin 1

increases expression
decreases expression

Ouabain results in increased expression of EDN1 mRNA
Ouabain results in decreased expression of EDN1 mRNA

PMID:15477225 PMID:28795476

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type A

increases expression

Ouabain results in increased expression of EDNRA mRNA; Ouabain results in increased expression of EDNRA protein

PMID:15477225 PMID:16982439

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

epidermal growth factor receptor

decreases phosphorylation

Ouabain results in decreased phosphorylation of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 2A

increases expression

Ouabain results in increased expression of EIF2A protein

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Ouabain results in increased expression of and results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 3, subunit K

affects expression

Ouabain affects the expression of EIF3K protein

NCBI chr 1:84,260,127...84,270,051
Ensembl chr 1:84,259,673...84,270,302

G

endonuclease G

increases expression

Ouabain results in increased expression of ENDOG protein

NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932

G

ERCC excision repair 4, endonuclease catalytic subunit

decreases expression

Ouabain results in decreased expression of ERCC4 mRNA

NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369

G

ETS proto-oncogene 1, transcription factor

decreases expression

Ouabain results in decreased expression of ETS1 mRNA

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

Fas associated via death domain

increases expression

Ouabain results in increased expression of FADD protein

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

FA complementation group D2

multiple interactions
decreases expression

Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]
Ouabain results in decreased expression of FANCD2 mRNA

NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412

G

FA complementation group F

decreases expression

Ouabain results in decreased expression of FANCF mRNA

NCBI chr 1:101,449,120...101,451,936
Ensembl chr 1:101,450,389...101,451,923

G

FA complementation group I

decreases expression
multiple interactions

Ouabain results in decreased expression of FANCI mRNA
Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]

NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640

G

phenylalanyl-tRNA synthetase 2, mitochondrial

increases expression

Ouabain results in increased expression of FARS2 mRNA

NCBI chr17:28,319,215...28,746,217
Ensembl chr17:28,319,280...28,746,337

G

Fas cell surface death receptor

increases expression

Ouabain results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

Ouabain results in increased expression of FASLG protein

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

F-box protein 32

multiple interactions

Ouabain affects the reaction [Botulinum Toxins, Type A affects the expression of FBXO32 mRNA]

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

fumarate hydratase

affects expression

Ouabain affects the expression of FH protein

NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266

G

FKBP prolyl isomerase 7

increases expression

Ouabain results in increased expression of FKBP7 mRNA

NCBI chr 3:61,609,384...61,623,710
Ensembl chr 3:61,608,557...61,623,280

G

fibronectin 1

decreases expression

Ouabain results in decreased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

GC, vitamin D binding protein

affects expression

Ouabain affects the expression of GC protein

NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567

G

glycine receptor, beta

increases expression

Ouabain results in increased expression of GLRB mRNA

NCBI chr 2:166,134,616...166,207,498
Ensembl chr 2:166,134,626...166,207,489

G

growth factor receptor bound protein 2

decreases expression

Ouabain results in decreased expression of GRB2 protein

NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309

G

GTP binding protein 6 (putative)

increases expression

Ouabain results in increased expression of GTPBP6 mRNA

NCBI chr12:46,574,913...46,578,873
Ensembl chr12:46,574,435...46,578,873

G

H2A.X variant histone

increases phosphorylation

Ouabain results in increased phosphorylation of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hes-related family bHLH transcription factor with YRPW motif 1

increases expression

Ouabain results in increased expression of HEY1 mRNA

NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312

G

hepatocyte growth factor

multiple interactions

Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
affects localization
increases activity

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; Ouabain results in increased phosphorylation of and results in increased expression of HIF1A protein
Ouabain results in increased activity of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heterogeneous nuclear ribonucleoprotein A2/B1

affects expression

Ouabain affects the expression of HNRNPA2B1 protein

NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249

G

heterogeneous nuclear ribonucleoprotein D-like

decreases expression

Ouabain results in decreased expression of HNRNPDL mRNA

NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506

G

hippocalcin-like 1

affects expression

Ouabain affects the expression of HPCAL1 protein

NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687

G

histidine-rich glycoprotein

affects expression

Ouabain affects the expression of HRG protein

NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389

G

heat shock protein family A (Hsp70) member 5

increases expression

Ouabain results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family D (Hsp60) member 1

affects expression
multiple interactions

Ouabain affects the expression of HSPD1 protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]; Ouabain results in decreased expression of and affects the localization of HSPD1 protein

PMID:17268060 PMID:18247327

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

inhibitor of DNA binding 2

increases expression

Ouabain results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

interleukin 2 receptor subunit alpha

decreases expression

Ouabain results in decreased expression of IL2RA mRNA

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

interleukin 2 receptor subunit beta

decreases expression

Ouabain results in decreased expression of IL2RB

NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054

G

interleukin 6

increases secretion
increases expression

Ouabain results in increased secretion of IL6 protein
Ouabain results in increased expression of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

increases expression

Ouabain results in increased expression of IL6R mRNA

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

integrin-linked kinase

decreases expression

Ouabain results in decreased expression of ILK mRNA

NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140

G

integrin subunit alpha V

decreases expression

Ouabain results in decreased expression of ITGAV mRNA

NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
decreases phosphorylation

Ouabain results in decreased expression of JUN mRNA
Ouabain results in decreased phosphorylation of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily D member 2

increases expression

Ouabain results in increased expression of KCND2 mRNA

NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728

G

potassium voltage-gated channel subfamily H member 2

decreases expression
decreases activity
multiple interactions

Ouabain results in decreased expression of KCNH2 protein modified form
Ouabain results in decreased activity of KCNH2 protein
Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium]

PMID:19139152 PMID:21158687

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

lymphoid enhancer binding factor 1

decreases expression

Ouabain results in decreased expression of LEF1 mRNA

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

galectin 1

affects expression
increases expression

Ouabain affects the expression of LGALS1 protein
Ouabain results in increased expression of LGALS1 protein

PMID:17268060 PMID:18247327

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

LIM domain kinase 1

decreases expression

Ouabain results in decreased expression of LIMK1 mRNA

NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606

G

lanosterol synthase

increases abundance

LSS protein results in increased abundance of Ouabain

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

mitogen-activated protein kinase kinase 6

increases expression

Ouabain results in increased expression of MAP2K6 mRNA

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK1 protein]
Ouabain results in decreased phosphorylation of MAPK1 protein

PMID:19687166 PMID:28795476

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK3 protein]
Ouabain results in decreased phosphorylation of MAPK3 protein

PMID:19687166 PMID:28795476

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 7

multiple interactions

Ouabain inhibits the reaction [palytoxin results in increased phosphorylation of and results in increased activity of MAPK7 protein]

NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267

G

malate dehydrogenase 2

affects expression

Ouabain affects the expression of MDH2 protein

NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271

G

MDM2 proto-oncogene

multiple interactions

Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

O-6-methylguanine-DNA methyltransferase

decreases expression

Ouabain results in decreased expression of MGMT protein

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

microRNA 29b-1

multiple interactions
decreases expression

MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]
Ouabain results in decreased expression of MIR29B1 mRNA

NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067

G

matrix metallopeptidase 13

decreases expression

Ouabain results in decreased expression of MMP13 mRNA

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

decreases expression
multiple interactions

Ouabain results in decreased expression of MMP2 mRNA
Ouabain results in decreased expression of and results in decreased activity of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression

Ouabain results in decreased expression of MMP9 mRNA; Ouabain results in decreased expression of MMP9 protein

PMID:28795476 PMID:33760381

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

muscle RAS oncogene homolog

decreases expression

Ouabain results in decreased expression of MRAS mRNA

NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408

G

myocardin related transcription factor A

decreases expression

Ouabain results in decreased expression of MRTFA mRNA

NCBI chr 7:112,544,305...112,714,418
Ensembl chr 7:112,544,312...112,714,418

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
increases expression

Ouabain results in decreased expression of MYC mRNA; Ouabain results in decreased expression of MYC protein
Ouabain results in increased expression of MYC protein

PMID:9653513 PMID:21215801

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin light chain 12A

increases expression

Ouabain results in increased expression of MYL12A protein

NCBI chr 9:110,891,970...110,899,655
Ensembl chr 9:110,873,959...110,916,580

G

myosin light chain kinase

decreases expression

Ouabain results in decreased expression of MYLK mRNA

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

nectin cell adhesion molecule 3

decreases expression

Ouabain results in decreased expression of NECTIN3 mRNA

NCBI chr11:54,362,712...54,469,351
Ensembl chr11:54,364,487...54,462,519

G

nectin cell adhesion molecule 4

increases expression

Ouabain results in increased expression of NECTIN4 mRNA

NCBI chr13:83,802,589...83,821,711
Ensembl chr13:83,803,184...83,821,709

G

neurofilament light chain

decreases expression

Ouabain results in decreased expression of NEFL mRNA

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

nitric oxide synthase 1

affects expression
increases expression

Ouabain affects the expression of NOS1 protein
Ouabain results in increased expression of NOS1 protein

PMID:12384489 PMID:15097235

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 3

multiple interactions
affects expression
increases expression

5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide inhibits the reaction [Ouabain results in increased expression of NOS3 protein]
Ouabain affects the expression of NOS3 protein

PMID:12384489 PMID:15477225

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NPC intracellular cholesterol transporter 2

decreases expression

Ouabain results in decreased expression of NPC2 mRNA

NCBI chr 6:104,397,239...104,418,161
Ensembl chr 6:104,378,644...104,418,155

G

natriuretic peptide A

increases expression
multiple interactions

Ouabain results in increased expression of NPPA mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:17266992 PMID:19687166

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

NRAS proto-oncogene, GTPase

decreases expression

Ouabain results in decreased expression of NRAS mRNA

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

Parkinsonism associated deglycase

affects response to substance

PARK7 affects the susceptibility to Ouabain

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein]; Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein]

PMID:24124520 PMID:31436044

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

decreases expression

Ouabain results in decreased expression of PCNA mRNA; Ouabain results in decreased expression of PCNA protein

PMID:20460749 PMID:21215801

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

programmed cell death 6

increases expression

Ouabain results in increased expression of PDCD6 protein

NCBI chr 1:28,966,518...28,982,188
Ensembl chr 1:28,966,518...28,982,189

G

prefoldin subunit 5

affects expression

Ouabain affects the expression of PFDN5 protein

NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516

G

profilin 1

affects expression
decreases expression

Ouabain affects the expression of PFN1 protein
Ouabain results in decreased expression of PFN1 protein

PMID:17268060 PMID:18247327

NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631

G

plasminogen activator, urokinase receptor

decreases expression

Ouabain results in decreased expression of PLAUR mRNA

NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595

G

phospholipase C, gamma 1

decreases expression

Ouabain results in decreased expression of PLCG1 mRNA

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

palmitoyl-protein thioesterase 2

decreases expression

Ouabain results in decreased expression of PPT2 mRNA

NCBI chr20:4,112,520...4,132,774
Ensembl chr20:4,122,463...4,132,774

G

protein kinase, DNA-activated, catalytic subunit

decreases expression

Ouabain results in decreased expression of PRKDC protein

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

proteasome 20S subunit beta 6

affects expression

Ouabain affects the expression of PSMB6 protein

NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

[Ouabain results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Nitric Oxide

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 2

decreases expression

Ouabain results in decreased expression of PTPN2 mRNA

NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627

G

RAB11B, member RAS oncogene family

increases expression

Ouabain results in increased expression of RAB11B protein

NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases expression

Ouabain results in decreased expression of RAF1 mRNA

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAS protein-specific guanine nucleotide-releasing factor 1

decreases expression

Ouabain results in decreased expression of RASGRF1 mRNA

NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269

G

regulator of G-protein signaling 2

decreases expression

Ouabain results in decreased expression of RGS2 mRNA

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

ras homolog family member H

increases expression

Ouabain results in increased expression of RHOH mRNA

NCBI chr14:42,341,135...42,371,971
Ensembl chr14:42,337,751...42,386,369

G

Rho-associated coiled-coil containing protein kinase 1

increases cleavage
multiple interactions

Ouabain results in increased cleavage of ROCK1 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein]

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

Rho-associated coiled-coil containing protein kinase 2

multiple interactions
increases cleavage

benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein]

NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031

G

replication protein A3

affects expression

Ouabain affects the expression of RPA3 protein

NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709

G

Rpgrip1-like

decreases expression

Ouabain results in decreased expression of RPGRIP1L mRNA

NCBI chr19:15,692,189...15,785,083
Ensembl chr19:15,692,150...15,785,083

G

ribosomal protein S6 kinase B1

affects expression

Ouabain affects the expression of RPS6KB1 mRNA

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

ryanodine receptor 2

multiple interactions
increases response to substance

K201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain]

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

G

S100 calcium binding protein A13

affects expression

Ouabain affects the expression of S100A13 protein

NCBI chr 2:175,999,439...176,005,933

G

S100 calcium binding protein B

increases expression

Ouabain results in increased expression of S100B protein

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

serum/glucocorticoid regulated kinase 1

multiple interactions
decreases expression

Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium]
Ouabain results in decreased expression of SGK1 mRNA

PMID:12590200 PMID:28795476

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

serum/glucocorticoid regulated kinase 2

multiple interactions

Ouabain inhibits the reaction [SGK2 protein results in increased transport of Potassium]

NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480

G

serum/glucocorticoid regulated kinase family, member 3

multiple interactions

Ouabain inhibits the reaction [SGK3 protein results in increased transport of Potassium]

NCBI chr 5:9,345,761...9,472,243
Ensembl chr 5:9,346,040...9,415,476

G

SHC adaptor protein 3

increases expression

Ouabain results in increased expression of SHC3 mRNA

NCBI chr17:13,652,247...13,772,710
Ensembl chr17:13,651,202...13,772,710

G

solute carrier family 16 member 1

multiple interactions

Ouabain inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 22 member 12

multiple interactions

Ouabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]

NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555

G

solute carrier family 5 member 5

multiple interactions

Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]

NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697

G

solute carrier family 5 member 6

multiple interactions

Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]

NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712

G

solute carrier family 8 member A1

affects response to substance
increases expression
multiple interactions

SLC8A1 affects the susceptibility to Ouabain
Ouabain results in increased expression of SLC8A1 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]

PMID:16166162 PMID:19897708

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

G

solute carrier family 9 member A1

multiple interactions
increases expression

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of SLC9A1 mRNA]

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

G

SMAD family member 4

decreases expression

Ouabain results in decreased expression of SMAD4 mRNA

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

snail family transcriptional repressor 1

decreases expression

Ouabain results in decreased expression of SNAI1 mRNA

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

Ouabain results in decreased expression of SOS1 protein

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

SOS Ras/Rho guanine nucleotide exchange factor 2

decreases expression

Ouabain results in decreased expression of SOS2 mRNA

NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692

G

sphingosine kinase 1

decreases expression

Ouabain results in decreased expression of SPHK1 mRNA

NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240

G

transforming growth factor, beta 1

decreases expression

Ouabain results in decreased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

decreases expression

Ouabain results in decreased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor, beta 3

decreases expression

Ouabain results in decreased expression of TGFB3 mRNA

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

transforming growth factor beta receptor 3

increases expression

Ouabain results in increased expression of TGFBR3 mRNA

NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341

G

talin 1

decreases expression

Ouabain results in decreased expression of TLN1 mRNA

NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900

G

talin 2

decreases expression

Ouabain results in decreased expression of TLN2 mRNA

NCBI chr 8:67,830,920...68,252,240
Ensembl chr 8:67,834,326...68,252,219

G

TNF receptor superfamily member 10b

increases expression

Ouabain results in increased expression of TNFRSF10A protein

NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467

G

tumor protein p53

multiple interactions

Ouabain results in decreased expression of and results in increased phosphorylation of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

triosephosphate isomerase 1

affects expression

Ouabain affects the expression of TPI1 protein

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

tumor protein, translationally-controlled 1

affects expression

Ouabain affects the expression of TPT1 protein

NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625

G

tripartite motif containing 63

multiple interactions

[Ouabain co-treated with Botulinum Toxins, Type A] affects the expression of TRIM63 mRNA

NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322

G

transient receptor potential cation channel, subfamily C, member 1

increases expression

Ouabain results in increased expression of TRPC1 protein

NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276

G

transient receptor potential cation channel, subfamily C, member 6

increases expression
multiple interactions

Ouabain results in increased expression of TRPC6 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

G

twist family bHLH transcription factor 1

increases expression

Ouabain results in increased expression of TWIST1 mRNA

NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653

G

thioredoxin 1

affects expression

Ouabain affects the expression of TXN protein

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

vimentin

decreases expression

Ouabain results in decreased expression of VIM mRNA

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

zinc finger homeobox 3

decreases expression

Ouabain results in decreased expression of ZFHX3 mRNA

NCBI chr19:36,257,196...36,886,104
Ensembl chr19:36,630,254...36,881,771

ponasterone A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

decreases activity
multiple interactions

ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

dynamin 1-like

multiple interactions

[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of DNM1L protein

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

fragile histidine triad diadenosine triphosphatase

affects expression

ponasterone A affects the expression of FHIT protein

NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340

G

fission, mitochondrial 1

multiple interactions

[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein]

NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377

G

mitofusin 2

increases expression

[ponasterone A results in increased expression of PINK1 protein] which results in increased expression of MFN2 protein

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

PTEN induced kinase 1

multiple interactions
increases expression

[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of DNM1L protein; [ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein]
[ponasterone A results in increased expression of PINK1 protein] which results in increased expression of MFN2 protein; ponasterone A results in increased expression of PINK1 protein

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases expression

ponasterone A results in increased expression of UGT1A3 protein

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

strophanthidin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases transport

ABCB1 protein results in increased transport of Strophanthidin

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

glucose-6-phosphatase catalytic subunit 1

increases expression
multiple interactions

Strophanthidin results in increased expression of G6PC1 mRNA
Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

interleukin 17A

multiple interactions

Strophanthidin results in increased expression of and results in increased secretion of IL17A protein

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 17F

multiple interactions

Strophanthidin results in increased expression of and results in increased secretion of IL17F protein

NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482

G

neuronal PAS domain protein 2

increases expression
multiple interactions

Strophanthidin results in increased expression of NPAS2 mRNA
Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320

G

RAR-related orphan receptor C

multiple interactions
increases expression

RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19911
chemical entity	19909
molecular entity	19880
polyatomic entity	19862
heteroatomic molecular entity	19818
hydroxides	19374
organic hydroxy compound	18978
hydroxy steroid	14469
14-hydroxy steroid	278
14alpha-hydroxy steroid +	18
14beta-hydroxy steroid +	267
Path 2
Term	Annotations
CHEBI ontology	19911
subatomic particle	19909
composite particle	19909
hadron	19880
baryon	19880
nucleon	19909
atomic nucleus	19880
atom	19909
main group element atom	19849
p-block element atom	19849
carbon group element atom	19766
carbon atom	19785
organic molecular entity	19785
organic molecule	19737
organic cyclic compound	19526
organic polycyclic compound	17311
steroid	14705
hydroxy steroid	14469
14-hydroxy steroid	278
14alpha-hydroxy steroid +	18
14beta-hydroxy steroid +	267

paths to the root