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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-hydroxy steroid
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Accession:CHEBI:36857 term browser browse the term
Definition:Any hydroxy steroid carrying a hydroxy group at position 2.
Synonyms:related_synonym: 2-hydroxy steroids


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2-hydroxy-17beta-estradiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor affects binding ISO 2-hydroxyestradiol binds to AR protein CTD PMID:14565775 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G CCND1 cyclin D1 increases expression EXP 2-hydroxyestradiol results in increased expression of CCND1 protein CTD PMID:23685341 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CKB creatine kinase B multiple interactions ISO 2-hydroxyestradiol inhibits the reaction [Estradiol results in increased expression of CKB] CTD PMID:10030690 NCBI chr14:103,519,667...103,522,833
Ensembl chr14:103,519,667...103,522,833
JBrowse link
G COMT catechol-O-methyltransferase increases methylation
affects metabolic processing
EXP
ISO
COMT protein results in increased methylation of 2-hydroxyestradiol
COMT protein affects the metabolism of 2-hydroxyestradiol
CTD PMID:11160877 PMID:15377160 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 affects chemical synthesis
multiple interactions
EXP
ISO
CYP1A1 protein affects the chemical synthesis of 2-hydroxyestradiol
2-hydroxyestradiol promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
[CYP1A1 protein results in increased oxidation of Estradiol] which results in increased chemical synthesis of 2-hydroxyestradiol; Resveratrol inhibits the reaction [CYP1A1 protein affects the chemical synthesis of 2-hydroxyestradiol]
CTD PMID:12093619 PMID:15142886 PMID:32781018 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases chemical synthesis
multiple interactions
EXP CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol
Carbaryl inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Chlorpyrifos inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Fonofos inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; naphthalene inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]
CTD PMID:16790556 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions EXP CYP1B1 protein affects the metabolism of [2-hydroxyestradiol co-treated with Glutathione] CTD PMID:14679015 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases chemical synthesis
multiple interactions
EXP CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol
Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol]; decamethrin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Fonofos inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Permethrin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol]
CTD PMID:16790556 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP 2-hydroxyestradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein] CTD PMID:9048584 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions
decreases expression
ISO
EXP
2-hydroxyestradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]
2-hydroxyestradiol results in decreased expression of ESR2 protein
CTD PMID:9048584 PMID:23685341 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FOXO1 forkhead box O1 decreases expression EXP 2-hydroxyestradiol results in decreased expression of FOXO1 protein CTD PMID:23685341 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G IGFBP1 insulin like growth factor binding protein 1 multiple interactions
increases expression
EXP 2-hydroxyestradiol promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]
2-hydroxyestradiol results in increased expression of IGFBP1 mRNA
CTD PMID:32781018 NCBI chr 7:45,888,488...45,893,660
Ensembl chr 7:45,888,360...45,893,660
JBrowse link
G MT-ATP6 mitochondrially encoded ATP synthase membrane subunit 6 increases expression EXP 2-hydroxyestradiol results in increased expression of ATP6 mRNA CTD PMID:9886577 NCBI chr MT:8,527...9,207
Ensembl chr MT:8,527...9,207
JBrowse link
G MT-CO3 mitochondrially encoded cytochrome c oxidase III increases expression EXP 2-hydroxyestradiol results in increased expression of COX3 mRNA CTD PMID:9886577 NCBI chr MT:9,207...9,990
Ensembl chr MT:9,207...9,990
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression EXP 2-hydroxyestradiol results in increased expression of MYC protein CTD PMID:23685341 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G PRL prolactin increases expression
multiple interactions
EXP 2-hydroxyestradiol results in increased expression of PRL mRNA
2-hydroxyestradiol promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]
CTD PMID:32781018 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA; Acetylcysteine inhibits the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]]; BAY 11-7085 inhibits the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]; BAY 11-7085 inhibits the reaction [Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]]; Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA] CTD PMID:18480072 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G SHBG sex hormone binding globulin increases expression EXP 2-hydroxyestradiol results in increased expression of SHBG mRNA; 2-hydroxyestradiol results in increased expression of SHBG protein CTD PMID:21793624 NCBI chr17:7,614,064...7,633,372
Ensembl chr17:7,613,946...7,633,382
JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 increases sulfation
affects sulfation
EXP SULT1A1 protein results in increased sulfation of 2-hydroxyestradiol
SULT1A1 gene polymorphism affects the sulfation of 2-hydroxyestradiol
CTD PMID:16517757 NCBI chr16:28,605,258...28,623,395
Ensembl chr16:28,603,944...28,623,625
JBrowse link
G SULT1A3 sulfotransferase family 1A member 3 affects sulfation EXP 2-hydroxyestradiol affects the sulfation of SULT1A3 protein CTD PMID:11358677 NCBI chr16:30,199,255...30,204,310
Ensembl chr16:30,199,228...30,204,310
JBrowse link
G SULT1E1 sulfotransferase family 1E member 1 affects sulfation EXP 2-hydroxyestradiol affects the sulfation of SULT1E1 protein CTD PMID:11358677 NCBI chr 4:69,841,212...69,860,151
Ensembl chr 4:69,841,212...69,860,145
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation EXP UGT1A1 protein results in increased glucuronidation of 2-hydroxyestradiol CTD PMID:14871858 PMID:15117964 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of 2-hydroxyestradiol CTD PMID:15117964 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,454...233,773,305
JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases glucuronidation EXP UGT1A3 protein results in increased glucuronidation of 2-hydroxyestradiol CTD PMID:15117964 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300
JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of 2-hydroxyestradiol CTD PMID:15117964 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300
JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of 2-hydroxyestradiol CTD PMID:15117964 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300
JBrowse link
2-hydroxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CKB creatine kinase B multiple interactions ISO 2-hydroxyestrone inhibits the reaction [Estradiol results in increased expression of CKB] CTD PMID:10030690 NCBI chr14:103,519,667...103,522,833
Ensembl chr14:103,519,667...103,522,833
JBrowse link
G ESR1 estrogen receptor 1 affects binding
multiple interactions
EXP 2-hydroxyestrone binds to ESR1 protein
2-hydroxyestrone binds to and results in increased activity of ESR1 protein
CTD PMID:16728493 PMID:17713618 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions EXP 2-hydroxyestrone binds to and results in increased activity of ESR2 protein CTD PMID:17713618 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FSHB follicle stimulating hormone subunit beta decreases expression EXP 2-hydroxyestrone results in decreased expression of FSHB protein CTD PMID:6401747 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261
JBrowse link
G LHB luteinizing hormone subunit beta decreases expression EXP 2-hydroxyestrone results in decreased expression of LHB protein CTD PMID:6401747 NCBI chr19:49,015,980...49,017,091
Ensembl chr19:49,015,980...49,017,091
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation EXP UGT1A1 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,454...233,773,305
JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases glucuronidation EXP UGT1A3 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300
JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300
JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300
JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation EXP UGT1A9 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300
JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of 2-hydroxyestrone CTD PMID:7835232 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652
JBrowse link
20-hydroxyecdysone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] CTD PMID:26048653 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G CASP3 caspase 3 increases activity EXP Ecdysterone results in increased activity of CASP3 protein CTD PMID:29126784 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] CTD PMID:26048653 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:26048653 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression
decreases expression
EXP Ecdysterone results in increased expression of HSPA5 mRNA
Ecdysterone results in decreased expression of HSPA5 protein
CTD PMID:29126784 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions
increases response to substance
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone
CTD PMID:26048653 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
brassinolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator decreases expression EXP brassinolide results in decreased expression of BCL2 protein CTD PMID:17557751 PMID:20833159 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP brassinolide results in decreased expression of BCL2L1 protein CTD PMID:20833159 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BID BH3 interacting domain death agonist decreases expression EXP brassinolide results in decreased expression of BID protein CTD PMID:20833159 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G CASP3 caspase 3 increases activity
increases expression
EXP brassinolide results in increased activity of CASP3 protein
brassinolide results in increased expression of CASP3 protein modified form
CTD PMID:17557751 PMID:20833159 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCNB1 cyclin B1 decreases expression EXP brassinolide results in decreased expression of CCNB1 protein CTD PMID:20833159 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 decreases expression EXP brassinolide results in decreased expression of CCND1 protein CTD PMID:20833159 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNE1 cyclin E1 decreases expression EXP brassinolide results in decreased expression of CCNE1 protein CTD PMID:20833159 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression EXP brassinolide results in decreased expression of CDK2 protein CTD PMID:20833159 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP brassinolide results in decreased expression of CDK4 protein CTD PMID:20833159 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP brassinolide results in increased expression of CDKN1A protein CTD PMID:20833159 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B decreases expression EXP brassinolide results in decreased expression of CDKN1B protein CTD PMID:20833159 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
JBrowse link
G ESR1 estrogen receptor 1 decreases expression EXP brassinolide results in decreased expression of ESR1 CTD PMID:20833159 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 affects localization
decreases expression
EXP brassinolide affects the localization of ESR2 protein
brassinolide results in decreased expression of ESR2
CTD PMID:20833159 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G MDM2 MDM2 proto-oncogene decreases expression EXP brassinolide results in decreased expression of MDM2 protein CTD PMID:20833159 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,845,544
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases expression EXP brassinolide results in decreased expression of RB1 protein; brassinolide results in decreased expression of RB1 protein modified form CTD PMID:20833159 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G TP53 tumor protein p53 increases expression EXP brassinolide results in increased expression of TP53 protein CTD PMID:20833159 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
digitonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH5 cadherin 5 multiple interactions EXP Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein] CTD PMID:31404653 NCBI chr16:66,366,657...66,404,784
Ensembl chr16:66,366,622...66,404,784
JBrowse link
G ETV2 ETS variant transcription factor 2 multiple interactions EXP Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr19:35,641,175...35,644,871
Ensembl chr19:35,641,745...35,644,871
JBrowse link
G GATA2 GATA binding protein 2 multiple interactions EXP Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 3:128,479,422...128,493,201
Ensembl chr 3:128,479,427...128,493,201
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Digitonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SPN sialophorin multiple interactions EXP Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr16:29,662,963...29,670,876
Ensembl chr16:29,662,979...29,670,876
JBrowse link
ponasterone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases activity
multiple interactions
ISO ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]
CTD PMID:16396944 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase affects expression EXP ponasterone A affects the expression of FHIT protein CTD PMID:17019711 NCBI chr 3:59,747,277...61,251,452
Ensembl chr 3:59,747,277...61,251,459
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein] CTD PMID:16396944 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases expression EXP ponasterone A results in increased expression of UGT1A3 protein CTD PMID:17058234 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24815
    chemical entity 24785
      molecular entity 24749
        polyatomic entity 24681
          heteroatomic molecular entity 24294
            hydroxides 22930
              organic hydroxy compound 20775
                hydroxy steroid 13235
                  2-hydroxy steroid 54
                    2-hydroxy-17beta-estradiol + 26
                    2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                    2-hydroxy-17beta-estradiol 3-sulfate 0
                    2-hydroxy-3-O-methyl estrone 0
                    2-hydroxyestradiol 3-methyl ether 0
                    2-hydroxyestrone + 12
                    2-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                    2-hydroxytestosterone + 0
                    2alpha-hydroxy steroid + 21
                    2beta-hydroxy steroid + 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 24815
    subatomic particle 24774
      composite particle 24774
        hadron 24774
          baryon 24774
            nucleon 24774
              atomic nucleus 24774
                atom 24774
                  main group element atom 24641
                    p-block element atom 24641
                      carbon group element atom 24436
                        carbon atom 24401
                          organic molecular entity 24401
                            organic molecule 24287
                              organic cyclic compound 23556
                                organic polycyclic compound 17740
                                  steroid 13712
                                    hydroxy steroid 13235
                                      2-hydroxy steroid 54
                                        2-hydroxy-17beta-estradiol + 26
                                        2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                                        2-hydroxy-17beta-estradiol 3-sulfate 0
                                        2-hydroxy-3-O-methyl estrone 0
                                        2-hydroxyestradiol 3-methyl ether 0
                                        2-hydroxyestrone + 12
                                        2-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                                        2-hydroxytestosterone + 0
                                        2alpha-hydroxy steroid + 21
                                        2beta-hydroxy steroid + 9
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